Well, according to Wikipedia, axolotls are one of the few amphibians who don't undergo metamorphosis, in which they would lose their gills and start living on land. Instead, they remain aquatic and gilled without taking to the land. This is because their body does not produce the proper hormone to undergo metamorphosis.
However, the axolotl can be given artifical hormones and be able to live on land. (THIS PRACTICE IS HIGHLY DISCOURAGED AS THIS COULD RESULT IN DEATH EVEN IN SUCCESSFUL ATTEMPTS).
Anyway, similar to giving an axolotls hormones to undergo metamorphosis, Mihari gives Mahiro hormones to undergo the "metamorphosis" of female adolescence and get him used to going outside.
The aquatic form of the axolotl is stuck in the video game world.
However, as soon as we see the land form of the axolotl, we cut to a game-over screen. And we see Mahiro, who is going through his own artificial metamorphosis to become a productive member of society.
Not a perfect analogy, but an interesting one to be honest.
The fact that the styles of the manga and anime are totally different just made me want to draw this lol
So here's anime Kaede and manga Kaede interacting
Today's AniAnimal is this cat in the Ending Theme that is a stand-in for the author of 'ONIMAI: I'm Now Your Sister!', Nekotofu.
今日のアニアニマルは『お兄ちゃんはおしまい!』のエンディングテーマ作者・ねことふの代役であるエンディングテーマの猫です