#Afoxolaner

[qingmupharmaceutical]

Afoxolaner: The Tick and Flea Terminator Unveiled

For pet owners waging war against pesky parasites, Afoxolaner API emerges as a formidable ally. This active ingredient, found in popular medications like NexGard® and Bravecto®, offers a potent weapon against both fleas and ticks, safeguarding our furry companions from these bothersome and potentially harmful pests. But what exactly is Afoxolaner, and how does it work its magic? Let's delve into the science behind this innovative parasite slayer.

From Molecules to Mite Mayhem:

Chemically speaking, Afoxolaner belongs to the isoxazoline class of compounds. These unique molecules target a specific part of the parasite's nervous system, the GABA-gated chloride channels. These channels act like tiny gateways, regulating the flow of ions that control nerve impulses. Afoxolaner disrupts these channels, essentially overloading the nervous system and leading to rapid paralysis and death of the parasite.

Mechanism of a Mite Massacre:

Imagine a flea or tick feasting on your unsuspecting pet. As it ingests Afoxolaner, the molecule enters its bloodstream and reaches its nervous system. The binding of Afoxolaner to the GABA channels throws the entire system into disarray, resulting in uncontrolled nerve impulses and ultimately, paralysis. This quick-acting process effectively eliminates the parasite within hours, providing long-lasting protection for your pet.

Benefits for Protected Paws:

For dogs and cats suffering from flea and tick infestations, Afoxolaner offers a multitude of benefits:

Broad-spectrum protection: Effective against a wide range of flea and tick species, including those resistant to other treatments.

Fast-acting and long-lasting: Starts working within hours and provides protection for up to 4-12 weeks depending on the formulation.

Convenient administration: Available in chewable tablets or topical spot-on applications, making treatment effortless.

Safe for most pets: Well-tolerated by dogs and cats of all ages and breeds, when used as directed by a veterinarian.

Beyond the Basic Bite:

While primarily used for flea and tick control, Afoxolaner might hold potential in other areas:

Mange treatment: Studies suggest its effectiveness in treating certain types of mange caused by mites.

Parasitic control in other animals: Research is ongoing to explore its use in cats, rabbits, and even livestock.

Combination therapies: Combining Afoxolaner with other medications might offer broader parasite control and prevent resistance development.

The Future of Afoxolaner:

Scientists continue to explore the diverse applications and potential improvements for Afoxolaner. Advancements in formulations, dosing schedules, and combination therapies are on the horizon, ensuring even better protection for our beloved pets.

Important Note:

This article is for informational purposes only and should not be construed as medical advice. Always consult your veterinarian for diagnosis and treatment recommendations tailored to your pet's specific needs.

Remember:

Afoxolaner is a prescription medication only available through veterinarians.

Follow your veterinarian's dosing instructions carefully.

Potential side effects, though uncommon, can occur. Consult your vet if you notice any concerns.

So, the next time you see your pet scratching relentlessly, remember the invisible shield Afoxolaner provides. This powerful API stands guard, ensuring your furry friend enjoys a life free from pesky parasites and the discomfort they bring.

[budgetpetcare]

Comparing Nexgard and Frontline Plus: The Best Treatment for Your Pet

Nexgard and Frontline Plus are two common treatments for fleas and ticks. In this article, we will compare their pros and cons and help you choose the best one for your pet.

[qingmupharma]

Afoxolaner API: A Powerful Tool in the Fight Against Canine Parasites

In the realm of veterinary medicine, the development of advanced pharmaceuticals has significantly improved the well-being of our four-legged companions. One such breakthrough is Afoxolaner, an active pharmaceutical ingredient (API) that has revolutionized the treatment and prevention of various parasitic infestations in dogs. In this article, we will explore what Afoxolaner API is and its diverse applications in safeguarding canine health.

Understanding Afoxolaner

Afoxolaner is a neurotoxic insecticide and acaricide that belongs to the isoxazoline class. It works by selectively targeting and inhibiting the nervous system of parasites, disrupting their ability to feed and survive. This unique mechanism of action makes Afoxolaner highly effective against a broad spectrum of external parasites, including fleas and ticks.

Flea Control

One of the primary applications of Afoxolaner API is in the control of fleas in dogs. Fleas are notorious pests that can cause a myriad of health issues, including allergic reactions, dermatitis, and the transmission of diseases. Afoxolaner disrupts the flea's nervous system, leading to rapid paralysis and death, effectively eliminating the infestation.

Tick Protection

Ticks pose a significant threat to dogs, as they can transmit various diseases such as Lyme disease and ehrlichiosis. Afoxolaner provides robust protection against ticks by incapacitating them upon contact. This proactive approach not only prevents tick infestations but also reduces the risk of disease transmission, promoting the overall health of the treated dogs.

Versatility in Formulations

Afoxolaner API is versatile and can be formulated into various administration forms, including oral tablets and spot-on treatments. This flexibility enhances its usability, allowing veterinarians and pet owners to choose the most convenient and effective method for their canine companions. The oral tablets are often favored for their ease of administration and quick absorption, providing rapid relief to dogs suffering from parasitic infestations.

Long-lasting Efficacy

One of the standout features of Afoxolaner is its prolonged efficacy. A single dose of Afoxolaner can provide protection against fleas and ticks for up to a month. This extended duration not only simplifies the dosing regimen for pet owners but also ensures continuous protection, reducing the likelihood of reinfestations and associated health issues.

Comprehensive Parasite Control

Apart from fleas and ticks, Afoxolaner also exhibits efficacy against other ectoparasites such as mites. This comprehensive approach to parasite control makes it a valuable tool in managing a range of infestations, offering a holistic solution to ensure the well-being of dogs.

Conclusion

In conclusion, Afoxolaner API has emerged as a powerful and versatile tool in the fight against canine parasites. Its unique neurotoxic mechanism of action, coupled with long-lasting efficacy and comprehensive coverage, has made it a go-to solution for veterinarians and pet owners alike. The development and widespread use of Afoxolaner represent a significant step forward in improving the quality of life for dogs, ensuring they can lead healthy and happy lives free from the burden of parasitic infestations. As research continues, we can anticipate further innovations in the field of veterinary medicine, building on the success of Afoxolaner in addressing the diverse challenges posed by external parasites in our beloved canine companions.

[sgpetcare]

How does nexgard for dogs work? Read it!

Nexgard is a popular oral flea and tick treatment for dogs, renowned for its efficacy and ease of use. Understanding Nexgard’s Active Ingredient - Nexgard’s active ingredient, afoxolaner, targets the nervous system of fleas and ticks, effectively disrupting their ability to feed and reproduce.

Read More

[avetblog]

NexGard & Bravecto

NexGard (afoxolaner)

Indication: protection against fleas, mites, ticks and flea tapeworms

Age: from 8 weeks of age and greater than 2 kg

Duration of Action: 1 month

Side effects: Well tolerated in most pets, but side effects may include: vomiting, itchy skin, lethargy

Available options:

Nexgard® Small dog: 1.8-4.5kg

Nexgard® Medium dog: 4.6-10.9 kg

Nexgard® Large dog: 11 – 27.2kg

Nexgard® Extra-large dog 27.3 – 54.4 kg

Bravecto (fluralaner)

Indication: ticks and fleas

Age: from 6 months of age and greater than 2 kg

BRAVECTO is approved for use in breeding, pregnant, and lactating dogs.

Duration: 3 months

Side effects: nausea, vomiting, decreased appetite, diarrhea, severe neurologic adverse events such as tremors, ataxia and seizures

Available Options:

[wwwsarms4musclecom]

cas: 1093861-60-9  Anthelmintic Drug Afoxolaner

CBNumber: CB72717660

Chemical Name: afoxolaner

Molecular Formula: C26H17ClF9N3O3

Formula Weight: 625.87

CAS No.: 1093861-60-9

Afoxolaner is the active principle of the veterinary medicinal products (alone), Frontpro (alone) and Spectra (in combination with milbemycin oxime). They are indicated for the treatment and prevention of flea infestations, and the treatment and control of tick infestations in dogs and puppies (8 weeks of age and older, weighing 4 pounds (~1.8 kilograms) of body weight or greater) for one month. These products are administered orally and poisons fleas once they start feeding.

How do I give my dog afoxolaner?

Afoxolaner is given by mouth in the form of a chewable tablet. The tablet should always be given as directed by your veterinarian. It can be given with or without food or water. Be sure the dog consumes the entire dose. If your dog vomits within 2 hours of dosing, give another full dose. Try giving the next dose with food.

afoxolaner contains afoxolaner which is absorbed into the bloodstream after ingestion. When fleas and ticks ingest blood containing afoxolaner, it causes hyperexcitation and death in these parasites.

[darilto-blog]

Top 5 Melhores Rémedios Para Carrapato de Cachorro 2022

Então vamos à lista dos 5 melhores rémedios para carrapato de cachorro em 2022.

em quinto lugar temos o Simparic 80 miligramas, Zoetis.

O remédio para carrapatos e pulgas Simparic é um dos mais eficazes disponíveis no mercado, indicado para cães que tenham a partir de 8 semanas de vida e pesem de 20 a 40 kilos.

Pode ser usado tanto se o pet estiver com parasitas quanto para prevenção.

Começa a eliminar esses parasitas do seu cão em apenas 3 horas após a ingestão do comprimido e é na forma de petisco para atrair o cão e muito palatável o que facilita a mastigação.

Um grande diferencial que é difícil de encontrar em outros medicamentos, é que ele também combate sarna dando proteção extra ao seu cãozinho.

Além disso, combate 11 espécies diferentes de carrapato evitando que seu pet contraia doenças que comprometam a vida.

em quarto lugar temos o Antipulgas e Carrapatos Frontline Plus, Frontline.

Produto importado, de fácil aplicação, vem em uma pipeta que é aplicada diretamente no corpo do cachorro, de preferência no pescoço para que o cachorro não consiga lamber o local.

É recomendado para cães de porte pequeno que tenham a partir de 8 semanas de vida, mas também pode ser usado em cadelas que estejam prenhas e em fase de amamentação.

Oferece proteção de 30 dias contra carrapatos, pulgas e piolhos mastigadores, para ter um melhor efeito, após a administração, o cão não pode tomar banho dentro das próximas 48 horas.

em terceiro lugar temos o Capstar da Elanco.

Com princípio ativo de nitenpiram, esse remédio para carrapato pode ser dado tanto para cachorros quanto para gatos que estejam infectados com parasitas.

No que diz respeito aos cães, especificamente, devem ter peso entre 11 e 57 kilos e pode tomar a partir de 4 semanas de vida.

Pode ser administrado também, tranquilamente, em fêmeas prenhas e em amamentação e em machos na fase de reprodução.

O comprimido pode ser tomado de novo após 24h de ingestão do último, porém, essa medida deve ser tomada com a autorização de um médico veterinário.

Esse remédio, começa a agir no corpo do animal 15 minutos após a ingestão, portanto, em pouco tempo seu cão já estará livre de pulgas.

Evita a reinfestação e o ideal é dar sempre que reparar que seu pet está com pulgas e miíase, isto é, infestação de larvas de moscas no cachorro.

em segundo lugar temos a Coleira Seresto Anti-Carrapatos e Pulgas.

Sem cheiro, resistente à água e não solta pó, a coleira Seresto tem grande proteção e sua durabilidade é de até 8 meses.

Protege de carrapatos, pulgas e larvas, tem 70 centimetros de comprimento e é indicada para cães com peso acima de 8 kilos e que tenham a partir de 7 semanas de vida.

A liberação do produto da coleira acontece de forma lenta e controlada e como protege de fora para dentro, ela evita que os parasitas se aproximem do seu pet desde o primeiro momento de uso.

O princípio ativo por trás desse remédio para pulgas e carrapatos são os compostos Imidacloprida e Flumetrina.

A coleira é ajustável e tem trava de segurança para não sair durante as brincadeiras do animal, assim, seu cão pode ser mover livremente.

Elimina a pulgas em até 24 horas e carrapatos em até 48 horas, portanto, a ação é muito rápida e eficaz.

e em primeiro lugar temos o NexGard Antipulgas e Carrapatos da Frontline Labs.

Esse remédio para pulgas e carrapatos também é um grande sucesso e seu grande diferencial é ser na forma de petisco no sabor carne e com textura macia para atrair o cão e facilitar a mastigação.

Garante proteção de 30 dias para seu pet contra pulgas, carrapatos, larvas e ovos e é indicado para filhotes, a partir dos 2 meses, e adultos.

É muito palatável e saboroso o que facilita a administração.

O princípio ativo é o composto Afoxolaner e tem ação rápida, uma vez que já começa a agir 8 horas após a ingestão do comprimido e também tira a coceira do pet para evitar machucados e inflamações decorrentes da ação de se coçar excessivamente.

Apesar de na embalagem vir 3 tabletes, deve ser dado apenas 1 por mês sendo que cada um tem 28,3 miligramas.

Apesar de ter um preço mais alto, ele vai durar por 3 meses, ou seja, bastante tempo de proteção até ter que comprar mais.

Agora que você já conhece o ranking com os 5 melhores rémedios para carrapato de cachorro em 2022, com certeza vai ficar mais fácil escolher o ideal para você.

[amcrasto]

Afoxolaner

Afoxolaner Molecular FormulaC26H17ClF9N3O3Average mass625.870 DaA1443AH252723 1093861-60-9[RN]1-Naphthalenecarboxamide,…

[canadapetsupplies]

                     Nexgard is a beef-flavored, monthly chewable that efficiently prevents and eliminates fleas and ticks on dogs. These yummy chews treat 4 kinds of tick species -- American dog ticks, Black-legged ticks, and Brown dog ticks and also may be used on puppies which are over 8 months old. The chew functions for one full month and also prevents canines from deadly tick-borne diseases. 

                     Nexgard, merchandise by Merial is the very best flea and tick preventative therapy that has Afoxolaner -- an insecticide and an acaricide. This active ingredient works to the central nervous system of the parasite causing hyperactivity. This finally results in the death of the parasite.

[doggosthings]

nexgard spectra,nexgard for dogs,Nexgard vs Nexgard Spectra,nexgard spectra usa,what does nexgard spectra cover,afoxolaner,nexgard heartworm,is nexgard for heartworms,nexgard spectra heartworm,Milbemycin Oxime,new nexgard

[petcarestores-blog]

Nexgard Spectra

Nexgard Spectra

  NexGard Spectra is an upgraded formula of the original NexGard, which controls tick and flea infestations on dogs. Nexgard Spectra combines afoxolaner and milbemycin, an anti-worm medicine, so as to provide nearly total parasite protection in one product. NexGard SPECTRA ® is delivered in a highly palatable beef-flavoured chew that kills adult fleas and is, indicated for the treatment and prevention of flea and tick infestations. Prevents heartworm disease and treats and controls hookworm, roundworm, whipworm, and lungworm infestations in dogs and puppies. NexGard Spectra is a monthly chewable treatment for dogs made with soy proteins and braised beef flavorings that dogs love.

Nexgard Spectra is a broad spectrum oral flea and tick treatment for dogs. It is extremely palatable due to its beef flavor, and is relished by dogs.

Make parasite protection easy and protect against fleas, ticks, mites, heartworm and intestinal worms - with just one tasty, monthly NexGard SPECTRA® chew!

Nexgard Spectra is a revolutionary new parasite prevention product which protects your dog from fleas, ticks, intestinal worms, and heartworms for a full month.

 protection that's available, in just one chew. No need for sprays or spot-ons, tablets, etc

[centralparkpawsblog]

How Does Dog Flea Treatment Work? Pills, Sprays, Shampoos, Collars, and Spot-On (Topical) Explained

https://img.chewy.com/is/image/catalog/146286_MAIN._AC_SL1500_V1559077991_.jpg There are many things I enjoy living in Minnesota, but the flea population isn’t one of them.

According to WebMD, Minnesota has one of the larger flea populations in the United States[1].

One good thing is fleas aren’t very hearty when it comes to the cold, so it is less likely dogs will get fleas in the colder months. Flea season in Minnesota is traditionally April through November.

Unfortunately, flea season is getting worse because our winters aren’t as severe and our warmer seasons are getting longer.

Also, if a flea is attached to a host in the winter, the host keeps the flea warm enough to continue to survive and procreate.

So, what do we do when you live in an area flush with fleas?

In our house, we use a variety of preventatives in our home for a few different reasons.

My two youngest dogs take Bravecto Chews every three months, whereas my two older girls get Frontline applied every month.

The reason why we use different methods is due to the various health issues in our home.

Also, we have chosen Bravecto and Frontline because they also help the fight against ticks, which is also an issue in our area.

Not sure if your dog is infested with fleas? We can help you figure that out!

How Do Flea Pills and Tablets Work?

Oral flea medications kill adult fleas, preventing them from laying eggs.

Most oral flea medications last at least 30 days and can be used to both prevent and treat flea infestations.

However, there is a treatment, Capstar, that’s solely used to manage flea infestations, and it only lasts 24 hours.

Most flea medications kill fleas by inhibiting aspects of their nervous systems, causing paralysis then death.

Simparica (Sarolaner)

Active Ingredients – Sarolaner[2]

How It Works – After your dog eats the Simparica chewable, the insecticide sarolaner enters the bloodstream. When fleas and ticks bite your pup, they will ingest the blood and die because sarolaner inhibits neurotransmitters such as GABA and glutamate[3]. Fleas die within 3 hours.

How to Use It – The chewable pill is liver flavored so most dogs will readily eat it like a treat. If not, it can be wrapped or hidden in food.

How Long It Lasts – 35 days

Side Effects – Most common side effects are vomiting and diarrhea[4]. In September of 2018, the FDA released a warning that stated isoxazoline class drugs might cause seizures and other neurological effects[5]; Simparica contains this class of drug.

Prescription Needed? – Yes

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NexGard (Afoxolaner)

Active Ingredients – Afoxolaner

How It Works – Afoxolaner is effective after 4 hours of ingestion. It is an adulticide and kills adult fleas by blocking GABA-gated chloride channels before the fleas can lay eggs[6].

How to Use It – Beef flavored chewable tablet

How Long It Lasts – 30 days

Side Effects – The most common side effects are vomiting, diarrhea, dry/flaky skin, lethargy, and lack of appetite[7]. In September of 2018, the FDA released a warning that stated isoxazoline class drugs might cause seizures and other neurological effects; NexGard contains this class of drug.

Prescription Needed? Yes

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Bravecto (Fluralaner)

Active Ingredients – Fluralaner

How It Works – Kills adult fleas after two hours of consuming the chewable tablet by inhibiting ligand-gated chloride channels, thus shutting down the flea’s nervous system[8].

How to Use It – Flavored chewable tablet

How Long it Lasts – 12 weeks

Side Effects – Common side effects are vomiting, decreased appetite, diarrhea, lethargy, polydipsia, and flatulence[9]. In September of 2018, the FDA released a warning that stated isoxazoline class drugs might cause seizures and other neurological effects; Bravecto contains this class of drug.

Prescription Needed? Yes

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Capstar (Nitenpyram)

Active Ingredients – Nitenpyram

How It Works – Kills adult fleas within 30 minutes after being given. Nitenpyram is a neonicotinoid that inhibits postsynaptic nicotinic acetylcholine receptors[10].

How to Use It – The tablet can be hidden in food or wrapped in a treat.

How Long It Lasts – 24 hours

Side Effects – Most frequent side effects are lethargy/depression, vomiting, itching, decreased appetite, diarrhea, hyperactivity, incoordination, trembling, seizures, panting, allergic reactions including hives, vocalization, salivation, fever, and nervousness[11].

Prescription Needed? Yes

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How Do Flea Collars Work?

There are three main types of flea collars on the market.

The first kind of collar acts strictly as a repellent. The repellent is released in gas form from the collar.

The second type of flea collar kills fleas after the flea has bitten your dog.

The third collar kills fleas on contact before the flea bites your dog.

Seresto

Active Ingredients – Imidacloprid and Flumethrin

How It Works – Imidacloprid kills adult fleas and their larvae by wreaking havoc with their postsynaptic nicotinic acetylchlorine receptors[12]. Flumethrin is a pyrethrin acts as a flea repellent by acting on sodium channels[13].

How to Use It – Remove the collar from the bag.  Make sure that the inside of the collar is free from any fragments from the plastic connectors. Guide the collar through the buckle and fasten around the dog’s neck.  There should be able to put two fingers in between the collar and your dog’s neck. Cut off and discard the excess length of the collar, leaving about a one-inch tail. Finally, fasten the reflective clips to the collar; do not put clips on the area the collar length overlaps.

How Long It Lasts – 8 months

Side Effects – Most common side effects are itching, hair loss, and skin irritation[14].

Prescription Needed? No

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Hartz Ultra Guard

Active Ingredients – Tetrachlorvinphos and Methoprene

How It Works – Tetrachlorvinphos kills adult fleas[15]. Methoprene prevents normal molting, egg-laying, egg-hatching, and development from the immature phase to the adult phase[16]. This collar also repels fleas.

How to use It – Remove the collar from the bag. Pull on both ends of the collar to activate the insecticide. Guide the collar through the buckle and fasten around the dog’s neck.  There should be able to put two fingers in between the collar and your dog’s neck.  Cut off the excess length of the collar, leaving about a one-inch tail.

How Long It Lasts – 7 months

Side Effects – Most typical side effects are skin irritation[17]. More severe side effects include diarrhea, vomiting, difficulty breathing, small pupils, muscle tremor, weakness or falling over, and drooling[18].

Prescription Needed? No

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Zodiac Flea & Tick Collar

Active Ingredients –Tetrachlorvinphos

How It Works –  Tetrachlorvinphos is an organophosphate that kills fleas and controls larvae by inhibiting acetylcholinesterase, disrupting the flea’s CNS and GI system[19]. The Zodiac collar also helps to repel fleas.

How to Use It – Remove the collar from the bag. Pull on both ends of the collar to activate the insecticide. Guide the collar through the buckle and fasten around the dog’s neck.  There should be able to put two fingers in between the collar and your dog’s neck.  Cut off the excess length of the collar, leaving about a one-inch tail.

How Long It Lasts – 7 months

Side Effects – Most likely side effects are skin irritation. More severe side effects include diarrhea, vomiting, difficulty breathing, small pupils, muscle tremor, weakness or falling over, and drooling.

Prescription Needed? No

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How Do Topical Flea Treatments Work?

Topical flea treatments are also called spot-on flea treatments.

Topical treatments consist of a liquid, usually applied between your dog’s shoulder blades. Applying the fluid between the shoulder blades prevents your dog from licking the treatment.

These treatments can be used to kill and sometimes even repel fleas.

Hartz Pet Defender Plus

Active Ingredients – Fipronil and Methoprene

How It Works – Fipronil works by blocking GABA-chloride and glutamate-chloride channels in the central nervous system in insects, ultimately killing the flea[20]. Methoprene prevents normal molting, egg-laying, egg-hatching, and development from the immature phase to the adult phase by replacing growth hormones[21].

How to Use It – Remove the tube from the packaging. Twist applicator tip to the right and at the same time push down to break the seal. Starting between your dog’s shoulder blades press the tube close to the skin. As you are squeezing, the tube move towards the tail, following the line of your dog’s spine.

How Long It Lasts – 1 month

Side Effects – Most typical side effect is skin irritation[22].

Prescription Needed? No

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Vectra 3D (Ceva)

Active Ingredients – Dinotefuran, Pyriproxyfen, Permethrin

How It Works –Vectra 3D repels and kills fleas, as well as interrupting all of the flea’s life stages. Dinotefuran is a neonicotinoid and pyriproxyfen mimics growth hormones making it an insect growth regulator[23], so Vectra 3D’s modes of action are all similar to other flea treatments above. Vectra starts working within 5 minutes after applying it.

How to Use It – Remove the tube from the packaging. Holding the tube upright, press down on the applicator tip until the two discs meet, breaking the internal seal.  Starting at the base of the tail, part the hair and squeeze the tube, running along the line of the spine until you reach your dog’s shoulder blades.

How Long It Lasts – 1 month

Side Effects – Most typical side effects light redness, itching, or other signs of discomfort where the treatment was applied.

Prescription Needed? No

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Frontline

Active Ingredients – Fipronil and Methoprene

How It Works – Fipronil works by disrupting the normal function of the central nervous system in insects, ultimately killing the flea. Methoprene prevents normal molting, egg-laying, egg-hatching, and development from the immature phase to the adult phase. Methoprene prevents the insects from reproducing.

How to Use It – Remove the tube from the packaging. Twist applicator tip to the right and at the same time push down to break the seal. Part the hair between your dog’s shoulder blades and apply entire contents in the single area.

How Long It Lasts – 1 month

Side Effects – The most common side effect is temporary irritation.

Prescription Needed? No

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Vet’s Best Flea & Tick Spot-on

Active Ingredients – Clove Oil 7.5%, Thyme Oil 2.5%, Cinnamon Oil 2.5%

How It Works – Kills and repels fleas through the use of pesticide-free ingredients. These essential oils can suffocate the flea and also have neurotoxic mechanisms[24].

How to Use It – Squeeze the tube at the point where the applicator and the tube meet; this will break the seal. Apply the liquid starting at the base of the neck and follow the line of the spine to the base of the tail.

How Long It Lasts – 1 month

Side Effects – The most common side effects are signs of sensitivity.

Prescription Needed? No

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How Do Flea Sprays Work?

Sprays work similarly to spot-on style treatments.

The spray kills fleas and prohibits the continued growth progression of larvae and eggs.

Vet’s Best Flea + Tick Spray for Dogs

Active Ingredients – Peppermint Oil 0.30%, Eugenol (from Clove plants) 0.70%, Sodium Lauryl Sulfate (plant-derived) 2.70%

How It Works – Peppermint oil and clove extract kill fleas and their eggs through physical and neurotoxic mechanisms, as mentioned above. SLS is a surfactant that aids in delivering the other ingredients to the inside of the flea[25].

How to Use It – Spray on your dog’s coat directly, but avoid contact with the face, eyes, and genitals. However, be sure to spray the legs, stomach, and tail. Do not saturate your dog’s coat.

How Long It Lasts – The description states that it is long-lasting, but should not be applied more than twice in 24 hours.

Side Effects – The most common side effects are signs of sensitivity.

Prescription Needed? No

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Adams Plus Flea and Tick Spray

Active Ingredients – Etofenpox, Methoprene, Piperonyl Butoxide

How It Works – Kills fleas, eggs, and larvae and impedes the flea’s growth cycle. Etofenpox disrupts sodium channels[26]. Methoprene replaces growth hormones. Piperonyl butoxide makes the other active ingredients more effective.

How to Use It – Shake well, then spray your dog’s entire body, including the tail, legs, and belly, but avoid their eyes, face, rectum, and genitals. With a cloth, gently apply to face around mouth, nose, and eyes. Spray until fully covered but not soaked.

How Long It Lasts – 2 months

Side Effects – Drooling may occur immediately after application.

Prescription Needed? No

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Frontline Spray

Active Ingredients – Fipronil 0.29%

How It Works –  Fipronil works by disrupting the normal function of the central nervous system in insects by affecting the neurotransmitters GABA and glutamate, ultimately killing the flea

How to Use It – Apply until your dog’s coat is damp. Work spray in with gloved hand when applying to your dog’s coat. Avoid spraying the face, eyes, and mouth. To apply to face, spray your gloved hand then wipe the product on the dog’s face and ears while avoiding the eyes.

How Long it Lasts – 1 month

Side Effects –Sensitivities are rare, but still may happen after using Frontline Spray[27].

Prescription Needed? No

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How Do Flea Shampoos Work?

Flea shampoos contain insecticides designed to kill fleas immediately and can also suffocate them.

Flea shampoos are used for when your dog has fleas or has been recently exposed to fleas.

These do not act as a potent preventative.

Richard’s Organics Flea & Tick Shampoo

Active Ingredients – Peppermint Oil, Eugenol (Clove Oil), Cedarwood Oil, Cinnamon Oil, Rosemary Oil, Sodium Lauryl Sulfate.

How It Works – Kills and repels fleas through mechanical (suffocation) and neurotoxic action.

How to Use It – Wet your dog’s coat down with water, then apply shampoo. Work the shampoo into your dog’s coat and allow to sit for five minutes before rinsing. Be careful not to let the shampoo to get into your dog’s eyes.

How Long It Lasts – The duration of the bath.

Side Effects – May cause skin irritation.

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Veterinary Formula Clinical Care Flea & Tick Shampoo

Active Ingredients – Pyrethrins, Piperonyl Butoxide, N-Octyl Bicyclopheptene Dicarboximide

How It Works – Kills fleas and soothes your dog’s skin from the irritations of the flea bites. Pyrethrins overexcite the flea’s neural pathways until the nerve cells are damaged, causing paralysis then death[28]. The other active ingredients make the pyrethrins more effective.

How to Use It – Wear rubber gloves when shampooing your dog. Wet your dog’s coat down with water, then apply shampoo. Work the shampoo into your dog’s coat and allow it to sit for five minutes before rinsing. Be careful not to let the shampoo to get into your dog’s eyes.

How Long It Lasts – The duration of the bath, but should not be repeated for 7 days. Also, it may take up to 30 days to completely resolve a flea infestation.

Side Effects – Skin sensitivities may occur after use.

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Adams Flea & Tick Cleansing Shampoo

Active Ingredients – Pyrethrins 0.075%, Piperonyl Butoxide 0.750%, Pyriproxyfen 0.086%

How It Works – Pyrethrins kills flea and pyriproxyfen disrupts the growth cycle and prevents eggs from hatching for up to thirty days.

How to Use It – Wet your dog’s coat down with water, then apply 1-2 tablespoons of shampoo. Work the shampoo into your dog’s coat and allow to sit for five minutes before rinsing. Be careful not to let the shampoo to get into your dog’s eyes. Repeat every seven to ten days until the fleas are gone.

How Long It Lasts – Up to 30 days for preventing flea eggs from hatching.

Side Effects – Skin sensitivities may occur after use.

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Which One to Use and When

There are a variety of different flea products on the market because there isn’t just one flea solution that will work with every situation.

Factors like your dog’s age, health, and activity level all play into which flea product would be best for your situation.

Scenario 1: Your Dog LOVES the Water

Hartz does make a water-resistant flea collar, though it won’t be as water resistant as other options

If your dog enjoys swimming and does so frequently, a flea collar may not be the best choice.

Many flea collars state that exposure to water is not recommended more than once a month.

In this situation, it would be best to consider using an oral medication or spot-on type treatment.

Oral medications do not have any water restrictions.

Topical treatments do not recommend exposure to water for 48 hours after application, but then do not have any water restrictions for the balance of the month.

Scenario 2: You Have a New Puppy and Want to Avoid Fleas

Flea products have different age ratings, so if you just picked up an eight-week-old puppy, then the best option is topical treatment.

Most spot-on treatments are safe to use with puppies eight weeks old and up.

Scenario 3: You Live in an Area That Fleas Aren’t a Problem, but Plan on Visiting an Area with a High Flea Population

Because your pet doesn’t require long term treatment, a spot-on or spray-on treatment would be best.

Just be sure to apply it in advance of traveling so that it has time to absorb into your dog’s skin and bloodstream.

Scenario 4: Your Pooch Has Fleas

Unfortunately, fleas happen.

Fleas love dog beds. Use flea control sprays to keep them away!

One time, I picked up a foster dog from animal control and she had fleas.

The first thing I did was to call my vet and get Capstar. Capstar works quickly and effectively to get rid of fleas.

The second thing I did after giving my foster Capstar was to apply Frontline.

After an hour, I felt safe to bring her home, but I did use flea spray on the dog’s bedding in my car and my house.

Using all three products avoided a flea infestation in my home while at the same time ridding my foster of her pesky fleas.

Side Note When Using Multiple Flea Products

Some products are safe to use together.

However, it’s always safest to consult your vet before combining products since overexposure to pesticides can cause toxicity issues in your dog.

Final Thoughts

Don’t forget to get a yard spray to protect your dog from bringing fleas in from outside!

If I could give any pet parent one piece of advice when it comes to fleas, it would be to use a flea preventative.

Avoiding a flea problem is, by far, the easiest way to deal with flea issues. Flea preventatives might seem pricey, but in truth, they are a lot cheaper than dealing with a flea infestation in your home!

I know there are many flea products on the market which can make it challenging to know which product would work best.

Hopefully, I was able to get you started in the right direction and help you narrow down the best solution for you and your dog.

Resources

https://pets.webmd.com/dogs/flea-tick-map-tool/default.htm

https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=91fc9ba1-35e6-4e37-8c37-c5e40699bd5b

https://www.drugs.com/vet/simparica-sarolaner-chewables.html

https://www.simparica.com/satisfaction-guarantee.aspx

https://www.popsci.com/flea-tick-seizure-fda/

https://www.sciencedirect.com/science/article/pii/S0304401714000934

https://vcahospitals.com/know-your-pet/afoxolaner

http://www.bravecto.net/faqs

https://www.drugs.com/vet/bravecto.html

https://www.sciencedirect.com/topics/veterinary-science-and-veterinary-medicine/nitenpyram

http://datasheets.scbt.com/sc-363355.pdf

http://npic.orst.edu/factsheets/archive/imidacloprid.html

https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/flumethrin

https://www.drugs.com/vet/seresto-small-or-large-dog.html

https://www.epa.gov/ingredients-used-pesticide-products/tetrachlorvinphos-tcvp

http://npic.orst.edu/factsheets/methogen.html

https://www.hartz.com/product/hartz-ultraguard-flea-tick-collar-dogs-black/

https://www.medvetforpets.com/know-flea-product-toxicity-dogs-cats/

https://pubchem.ncbi.nlm.nih.gov/compound/Tetrachlorvinphos

http://npic.orst.edu/factsheets/archive/fiptech.html

http://npic.orst.edu/factsheets/methogen.html

https://vcahospitals.com/know-your-pet/fipronil

http://npic.orst.edu/factsheets/pyriprogen.html

https://onlinelibrary.wiley.com/doi/full/10.1111/mve.12033

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283952/

https://www.centrallifesciences.com/active-ingredients/etofenprox

https://www.drugs.com/vet/frontline-spray-treatment-for-cats-dogs.html

https://www.sciencedirect.com/science/article/pii/S0300483X01005698

The post How Does Dog Flea Treatment Work? Pills, Sprays, Shampoos, Collars, and Spot-On (Topical) Explained appeared first on Central Park Paws.

from https://www.centralparkpaws.net/flea-medication/how-does-dog-flea-treatment-work/

[drjeandoddspethealthresource]

FDA Issues Warning about Flea and Tick Products

The US Food and Drug Administration (FDA) issued a warning on September 20, 2018 about the isoxazoline flea and tick products fluralaner for dogs and cats (Bravecto®), afoxalaner for dogs (Nexgard®), and saroloner for dogs (Simparica®). The recently introduced isoxazoline, lotilaner (Credelio®) for dogs falls into this same class.

Dogs and cats with no known prior medical history of muscle tremors, ataxia, and seizures have experienced those adverse reactions to this class of flea and tick preventive pesticides. While the FDA is not pulling the four flea and tick preventatives off the market at this time, they will all have to carry an FDA warning on their packaging.

Clinical, evidenced-based reports have been coming forward for the past several years and many studies are currently percolating about the reported adverse reactions to isoxazolines, synthetic pesticides. Dr. Jean Dodds is currently on a privately convened expert committee researching this topic and their report should be issued soon.

Oftentimes when information such as this is brought to light, veterinarians and researchers can point to certain breed characteristics, age, drug interactions, or genetic mutations. For instance, dogs that are epileptic or prone to seizures should not have spinosads – a natural substance made by a soil bacterium that can be toxic to insects – that is also for treatment or prevention of fleas. Two of the most well-known spinosad products are Trifexis® and Comfortis®.

Another example is the MDR1 gene mutation. This gene undergoes one or more mutations that allow a higher absorption of drugs and toxic substances to enter the central nervous system and then can breach the blood-brain barrier and create adverse reactions. Plus, we know that this gene mutation is most commonly found in dog breeds of herding breed ancestry. According to the Washington State Veterinary Clinical Pharmacology Lab, nearly three of every four Collies in the US have the mutant MDR1 gene. The frequency is about the same in France and Australia, so it is likely that most Collies worldwide have the mutation. The MDR1 mutation has also been found in Shetland Sheepdogs (Shelties), Australian Shepherds, Old English Sheepdogs, English Shepherds, German Shepherds, Long-haired Whippets, Silken Windhounds, and a variety of mixed breed dogs.

This is where this can get tricky with the MDR1 gene mutation. FDA-approved antiparasitic drugs such as ivermectin (Heartgard), selamectin (Revolution), milbemycin oxime (Interceptor) and moxidectin (Advantage Multi; Proheart 6) have been tested and found safe for MDR1-affected dogs when given at the prophylactic heartworm preventative dosage level. Despite this commentary, the present author does not recommend several of these products, especially for toy and small breeds and puppies or those with or at familial risk for autoimmune disorders, including vaccinosis.

Further, if a heartworm preventative is given with a spinosad, isoxazoline, ketoconazole, itraconazole, fluconazole or related antifungals, then serious drug-drug interactions can occur in dogs that have the MDR1 mutation.

While we have known about the MDR1 mutation situation before, the scary part now about the isoxazoline class of drugs is that researchers and veterinarians thus far cannot point to breed characteristics, age group, drug interactions or genetic mutations as contributing factors to the latest findings that prompted the FDA warning. These adverse reactions to the isoxazoline class appear to be affecting pets randomly.

As of May 4, 2018, 420 reports of worldwide adverse reactions to these pesticides in humans have been given to the European Medical Agencies (EMA). These reactions include breathing problems, skin conditions, and even seizures and the onset occurred after handling the chewable or spot-on treatment of fluralaner. Causality assessment at that time was placed at: 37 as probable, 13 as possible, 4 unclassifiable, 3 inconclusive, and the rest have not been assessed.

What is possibly most concerning is the introduction of Exzolt®, which curbs red poultry mites. Red poultry mites can cause anemia, disease susceptibility and higher mortality rates in chickens. Exzolt® is made of the same isoxazoline (fluralaner), which is sold as Bravecto® for dogs and cats. The EMA recommended to the European Union to approve Exzolt® use through water treated with the product. As of September 2017, the product was being marketed in Europe. The withdrawal period for meat from chickens treated with Exzolt® is 14 days. The withdrawal period for eggs from chickens treated with Exzolt® is zero days, which means there is no mandatory waiting time.

We have written extensively about the use of medications in livestock and how many of them can be passed up the food chain. We do not know definitively whether Exzolt® is passed up the food chain. Clearly, we believe that the EMA needs to reconsider its use.

After a search on the FDA’s website for fluralaner, afoxolaner, sarolaner and lotilaner, the use of these isoxazoline drugs is not approved for use in livestock or food producing animals.

If your companion dog or cat is not prone to fleas or you do not live in a tick-infested area, there is no reason to give flea and tick medications as preventatives. If these bugs attach themselves, you can use flea shampoos and combs, or specially designed tick removers. It is a little bit more work, but your companion pet’s health is worth it.

W. Jean Dodds, DVM Hemopet / NutriScan 11561 Salinaz Avenue Garden Grove, CA 92843

References

“Animal Drug Safety Communication: FDA Alerts Pet Owners and Veterinarians About Potential for Neurologic Adverse Events Associated with Certain Flea and Tick Products.” U.S. Food and Drug Administration, 20 Sept. 2018, http://www.fda.gov/AnimalVeterinary/NewsEvents/CVMUpdates/ucm620934.htm.

Dodds, Jean. “Heartworm: A Real and Present Danger.” Dr. Jean Dodds' Pet Health Resource, 3 May 2015, http://www.drjeandoddspethealthresource.tumblr.com/post/118052606336/heartworm-dogs-danger#.W7OlAWhKjIV.

Dodds, Jean. “MDR1 Gene Mutation in Dogs.” MDR1 Gene Mutation in Dogs, 26 May 2017, http://www.drjeandoddspethealthresource.tumblr.com/post/158855646346/mdr1-gene-mutation-in-dogs-and-cats#.W7OmzWhKjIV.

“Exzolt.” European Medicines Agency, 20 Oct. 2017, http://www.ema.europa.eu/medicines/veterinary/EPAR/exzolt.

“MSD Animal Health Launches First Systemic Treatment for Poultry Red Mites; EXZOLT® Eliminates Infestations in European Poultry Houses.” Merck Animal Health, 5 Sept. 2017, http://www.merck-animal-health.com/news/2017-09-05.aspx.

[drferox]

How do I pick a parasite preventative for my cat or dog? It seems like there are more options for dogs + it doesn't seem like any one product does everything. Should an indoor cat be on something now I have a dog potentially exposing him to parasites? Do I need a flea preventative if the heartworm preventative does flea eggs? What kind of extra protection should I do when I bring my dog on vacation to somewhere with more risk of fleas and ticks?

You should be asking this question of your local vet, because they will know both which products are available and what coverage you will actually need. Not all places on the planet have ticks, hydatid tapeworm or heartworm, for example. So ask the local clinic for specific advice. I will attempt to avoid brand names.

Yes, there are more options available for dogs than there are for cats. This is because some insecticides are toxic to cats, so those products can’t be used at all, cats are physically more difficult to give medication to, and cat health products have a smaller market share. Companies that research and develop drugs are, at least in part, in it for the money and people spend more on dogs than on cats.

A lot of so-called ‘all in one products’ don’t actually do everything. Many don’t do ticks, but tick protection is not necessarily required in every corner of the planet, and most don’t do tapeworm. The later is because only praziquantel is the only drug that actually treats tapeworm, and it’s both difficult to administer transdermally (across the skin) and tastes awful, making those ‘palatable monthly chews’ taste not so good.

That said, if the animal is on regular flea control, eats a cooked or processed diet and has no access to hunting, it might not strictly need a tapewormer. Raw fed pets should have occasional tapeworm treatments, especially if you’re in a hydatid area.

It would be ideal for your indoor cat to still have some form of protection if the dog is potentially bringing fleas inside. This will depend on where you are, and how prevalent the fleas are locally.

If you are using a product that kills flea eggs, you may still need to use the occasional treatment to kill adult fleas if they are present. If you are going temporarily to a location that has ticks, you should use tick prevention in addition to regularly checking your pets.

And boy oh boy the market for parasiticides is huge and changing all the time. It’s where the big money is in veterinary pharmacology and it’s a hugely competitive market. Heck, I am probably not completely up to date with them, but I can give you a run down of basic options.

For dogs, you can consider:

An annual heart worm injection, plus 3 monthly worming tablets, plus either monthly flea/tick control or 3-monthly flea/tick control, or one of the few vet approved flea/tick collars

Monthly all-in-one protection for fleas/heartworm/intestinal worms, tapeworm and tick treatments depending on lifestyle factors

For cat’s we have less combinations available:

Monthly all-in-one protection for fleas/heartworm/intestinal worms and occasional tapeworm tablet if required.

Monthly flea protection, 3 monthly worming tablets, and just kind of cross your fingers on the heartworm thing.

Heartworm and tick control in cats has far less options that dogs, and again I recommend checking with your local vet for specific products in your region.

And since I can almost guarantee that someone will have popped into my ask box already to ask about flea control after the last post, here’s the basic rundown on them. Again, I’m avoiding brand names and sticking to active ingredients.

Not recommending Fipronil based products anymore. Can’t even give them away.

Imidacloprid doesn’t seem to have as much immunity out there, but will probably be the next to go.

I’ve even had to raise a polite eyebrow in question towards Selamectin lately.

Spinosad has been my personal savior for problem flea infestations in cats and dogs.

Fluralanerseems to work really well on a range of ectoparasites but is dog only.

Afoxolaner and Sarolaneralso seem to be highly promising, but I haven’t used them as much.

But I will not give anyone online a specific recommendation, and will always refer this discussion back to their local vet, because local knowledge matters when it comes to parasites.

[goelvetpharmaofficial]

Fleas: What is it and to prevent it in your dogs?

Ticks are blood-sucking, disease-carrying insects. In reality, a tick bite can carry a variety of diseases that can be passed to your cat. Lyme disease, babesiosis, ehrlichiosis, and tick paralysis are some of the most prevalent tick-borne disorders. Let's have a look at some of the ailments that these pathogenic ectoparasites cause. Fleas, like ticks, are microscopic flightless insects that belong to the ectoparasite family, which operate as external parasites on mammals and birds. Fleas feed on the blood of their hosts to survive. Ticks and fleas vary in those ticks are attached to the body [skin], where they suck blood and become engorged, whereas fleas suck blood but do not remain attached to the skin. Instead, fleas move from body-to-body running from one host to another. So, How to prevent Dogs with Flea Shampoo and Tick Shampoo?

How To Protect Your Dogs from Tick and Fleas:

Ticks and fleas can cause havoc since they can carry dangerous pathogenic organisms such as Babesia, Ehrlichia, and dipylidium [tapeworm], but we can always protect our dogs by taking preventative steps.

1. SPRAYS, SPOT-ONS, AND SHAMPOOS

On the market, there are a variety of chemical-based anti-tick and anti-flea sprays. These medications work by destroying fleas and ticks on the human body. Fipronil, nitenpyram, afoxolaner, fluralaner, or spinosad are chemical compounds that are essentially active against these ectoparasites, bringing relief to your dogs from the flea-tick annoyance.

2. ME & MY TICKS & FLEA PET SHAMPOO

I & My Anti-Ticks & Flea Pet Shampoo by Goel Vet Pharma is manufactured with natural components like Tea Tree and Neem Extract. This shampoo is the most effective against ticks and fleas, ensuring that your pet is not only protected against ticks and fleas but also has healthy skin and fur thanks to its natural ingredients.

3. SAFEGUARD YOUR BACKYARD

If your backyard has been infected with ticks and fleas, you can use insecticide sprays or call pest control to protect your dogs and maintain a sanitary atmosphere. In this manner, you'll always have two layers of defense against these pests.

4. BRUSH THE PET OFTEN

Brushing your pet's fur with a comb, as simple as it sounds, can assist you in discovering or noticing fleas and ticks as soon as possible, allowing you to take required precautions!

Goel Vet Pharma is a Chittorgarh-based approach towards homeopathic solutions for veterinary problems. Goel Vet Pharma Private Limited provides homeopathic solutions to the various sicknesses and conditions for cattle, sheep, goats, dogs, and cats. With more than 10,000 professionals in the team of Goel Vet team, the company prescribes their products to over 10 lakh animals and treats various diseases with their Homeopathic Veterinary medicines in Cows, Buffalo, and pet animals. They are also known for introducing homeopathic supplements for pets for the pet parents who are concerned about the weak condition of their pets. Goel Vet Pharma is available online and also has a Goel Vet Pharma application on Playstore. Goel Pharma is ISO 9001-2008 certified, FDA approved, and certified in production, consultation, and distribution in the arena of Homeopathic Veterinary Medicine all over India. Goel Vet Pharma company is set up by Dr. R K Goel who was a scholar and pioneer in homeopathic services for the animals. He had come up with various formulations for diseases like mastitis, FMD, HS, meningitis, etc with high success rates with his 33-year long service. He has compiled all his work to form the Goel Vet Pharma for dedication to building a strong homeopathic reign in the veterinary sector.

[csdataabase]

Nextgard Customer Service

If you are looking for nextgard customer service, simply check out our links below : 1. Contact Us| NexGard® https://nexgardfordogs.com/contact-us NexGard® (afoxolaner) is for use in dogs only. The most frequently reported adverse reactions include vomiting, itching, lethargy, diarrhea, and lack of appetite. 2. Contact Us | NexGard Caribbean https://www.nexgardcar.com/contact Contact Us…