#All India Databases

[allindiadatabase]

7 Features of All India Complete Databases

Complete databases covering all of India would typically encompass a wide range of features to provide comprehensive information. Here are seven key features such databases might include:

Geographical Coverage: The database would cover all states, union territories, districts, and possibly even specific regions within India, ensuring comprehensive coverage of the entire country.

Demographic Data: It would include demographic information such as population statistics, age distribution, gender ratio, literacy rates, and other socio-economic indicators.

Economic Data: This feature would provide data on the economy of different regions within India, including gross domestic product (GDP), sectors contributing to GDP, employment rates, income levels, poverty rates, etc.

Administrative Information: Details on administrative divisions, government offices, electoral information, political representation, and other governance-related data would be included.

Infrastructure Data: Information on infrastructure such as roads, railways, airports, ports, electricity availability, water supply, and other essential facilities would be part of the database.

Cultural and Historical Information: This feature might cover cultural heritage sites, historical landmarks, languages spoken, religious demographics, festivals, and other cultural aspects of various regions in India.

Sector-specific Data: Specific databases might focus on certain sectors like healthcare, education, agriculture, manufacturing, tourism, etc., providing in-depth information and statistics relevant to those sectors nationwide.

Ultimately, All India Database’s All India Complete Database goes beyond being a mere data repository. It is a valuable strategic asset that enables businesses to seize new possibilities, forge essential relationships, and attain sustainable growth in the face of fierce competition in today’s marketplace. Read more: 7 Features of All India Complete Databases

[klusterfirst]

What’s Slowing Down Your Database? Find Out How to Fix It Fast!

Is your database running slower than it should? A sluggish database can hurt your business in many ways—from delayed decisions to frustrated customers. The good news? You can fix it fast with database performance optimization!

Why Is My Database Slow?

Here are the main reasons your database might be lagging:

Poor Query Performance – Inefficient queries can slow down data retrieval.

Lack of Indexing – Without proper indexing, your database struggles to find data quickly.

Overloaded Servers – Too much traffic can overwhelm your servers and slow performance.

Fragmentation – Over time, data fragmentation can cause slower read and write times.

Outdated Hardware – Old servers may not be able to handle your database's needs.

How to Fix It Fast

Optimize Queries – Rewrite inefficient queries and use proper indexing to speed things up.

Rebuild Indexes – Regular indexing can help improve data retrieval speed.

Monitor Servers – Keep an eye on server performance and upgrade as needed.

Defragment Your Database – Regular maintenance helps avoid slowdowns.

Cloud Migration – Move to the cloud for better scalability and performance.

Don’t let a slow database hold your business back. At KLUSTERFIRST, we specialize in optimizing database performance. Contact us today to make sure your data is working for you at its best!

[qs-23]

Maximizing Efficiency: Job Seekers Database Strategies

Maximizing efficiency with job seekers database strategies involves organizing and updating data regularly to ensure you can quickly find the best candidates. Using advanced search filters and categorizing candidates based on skills and experience can streamline the hiring process, saving time and resources.

Read More:

[oldcompanysale]

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[reasonsforhope]

Camera-trapping data revealed in a new study show a steady recovery of tigers in Thailand’s Western Forest Complex over the past two decades.

The tiger recovery has been mirrored by a simultaneous increase in the numbers of the tigers’ prey animals, such as sambar deer and types of wild cattle.

The authors attribute the recovery of the tigers and their prey to long-term efforts to strengthen systematic ranger patrols to control poaching as well as efforts to restore key habitats and water sources.

Experts say the lessons learnt can be applied to support tiger recovery in other parts of Thailand and underscore the importance of the core WEFCOM population as a vital source of tigers repopulating adjacent landscapes.

The tiger population density in a series of protected areas in western Thailand has more than doubled over the past two decades, according to new survey data.

Thailand is the final stronghold of the Indochinese tiger (Panthera tigris corbetti), the subspecies having been extirpated from neighboring Cambodia, Laos and Vietnam over the past decade due to poaching, habitat loss and indiscriminate snaring...

Fewer than 200 tigers are thought to remain in Thailand’s national parks and wildlife sanctuaries, only a handful of which are sufficiently undisturbed and well-protected to preserve breeding tigers. 

The most important of these protected areas for tigers is the Huai Kha Khaeng Thung Yai (HKK-TY) UNESCO World Heritage Site, which comprises three distinct reserves out of the 17 that make up Thailand’s Western Forest Complex (WEFCOM). Together, these three reserves — Huai Kha Khaeng Wildlife Sanctuary, Thungyai Naresuan West and Thungyai Naresuan East — account for more than a third of the entire WEFCOM landscape.

Now, a new study published in Global Ecology and Conservation documents a steady recovery of tigers within the HKK-TY reserves since camera trap surveys began in 2007. The most recent year of surveys, which concluded in November 2023, photographed 94 individual tigers, up from 75 individuals in the previous year, and from fewer than 40 in 2007.

Healthy tiger families  

The study findings reveal that the tiger population grew on average 4% per year in Hua Kha Khaeng Wildlife Sanctuary, the largest and longest-protected of the reserves, corresponding to an increase in tiger density from 1.3 tigers per 100 square kilometers, to 2.9 tigers/100 km2. 

“Tiger recoveries in Southeast Asia are few, and examples such as these highlight that recoveries can be supported outside of South Asia, where most of the good news [about tigers] appears to come from,” said Abishek Harihar, tiger program director for Panthera, the global wildcat conservation organization, who was not involved in the study.

Among the camera trap footage gathered in HKK-TY over the years were encouraging scenes of healthy tiger families, including one instance of a mother tiger and her three grownup cubs lapping water and lounging in a jacuzzi-sized watering hole. The tiger family stayed by the water source for five days during the height of the dry season.

The team of researchers from Thailand’s Department of National Parks, Wildlife and Plant Conservation, the Wildlife Conservation Society, Kasetsart University, and India’s Center for Wildlife Studies deployed camera traps at more than 270 separate locations throughout the HKK-TY reserves, amassing 98,305 days’ worth of camera-trap data over the 19-year study period.

Using software that identifies individual tigers by their unique stripe patterns, they built a reference database of all known tigers frequenting the three reserves. A total of 291 individual tigers older than 1 year were recorded, as well as 67 cubs younger than 1 year [over the course of the study].

Ten of the tigers were photographed in more than one of the reserves, indicating their territories straddled the reserve boundaries. The authors conclude that each of the three reserves has a solid breeding tiger population and that, taken together, the HKK-TY landscape is a vital source of tigers that could potentially repopulate surrounding areas where they’ve been lost. This is supported by cases of known HKK-TY tigers dispersing into neighboring parts of WEFCOM and even across the border into Myanmar.

Conservation efforts pay off

Anak Pattanavibool, study co-author and Thailand country director at the Wildlife Conservation Society, told Mongabay that population models that take into account the full extent of suitable habitat available to tigers within the reserves and the likelihood that some tigers inevitably go undetected by camera surveys indicate there could be up to 140 tigers within the HKK-YT landscape.

Anak told Mongabay the tiger recovery is a clear indication that conservation efforts are starting to pay off. In particular, long-term action to strengthen systematic ranger patrols to control poaching as well as efforts to boost the tigers’ prey populations seem to be working, he said.

“Conservation success takes time. At the beginning we didn’t have much confidence that it would be possible [to recover tiger numbers], but we’ve been patient,” Anak said. For him, the turning point came in 2012, when authorities arrested and — with the aid of tiger stripe recognition software — prosecuted several tiger-poaching gangs operating in Huai Kha Khaeng. “These cases sent a strong message to poaching gangs and they stopped coming to these forests,” he said."

...ranger teams have detected no tiger poaching in the HKK-TY part of WEFCOM since 2013.

-via Mongabay News, July 17, 2024

[aroaessidhe]

I had an idea the other day to make a list of ace & aro books based on where in the world they're set! Which, since I'm mostly excluding the US and there's a lot of secondary world sff, is ridiculously small

see my database for details on aspec content, a couple of these are side characters or brief mentions, or one character in an ensemble; not inherent recommendations, etc

Oceania

The Bone People (Aotearoa)

The Space Ace of Mangleby Flat (Aotearoa & Australia)

The Spider & Her Demons (Australia)

Two Can Play That Game (Australia)

An Accident of Stars (portal fantasy, starts in Australia)

Summer Bird Blue (Hawai'i)

Be The Sea (Hawai'i)

Asia

Small Gods of Calamity (South Korea)

Breasts & Eggs (Japan)

Convenience Store Woman (Japan)

She Loves to Cook, and She Loves to Eat (Japan)

Is Love The Answer? (Japan)

Foul Lady Fortune (China)

She Who Became The Sun (China)

Stuck In her Head (Hong Kong)

Kaikeyi (Ancient India)

Nigeria

Until The Last Petal Falls

Vagabonds!

Jamaica/Caribbean

Sailing by Orion's Star (colonised, piracy era)

Europe

Smile and Be A Villain (Denmark/Germany)

The Reckless Kind (Norway)

The Spy With The Red Balloon (Germany/US)

Little Black Bird (Poland)

Let The Dead Bury The Dead (Russia)

The Last (apocalyptic Switzerland)

UK

Song of the Huntress (Ancient Britain)

Life Underwater (England)

The Murder Next Door (England)

Small Joys (England)

Fallen Thorns (England)

Cupid Calling (England)

If You Still Recognise Me (England)

Something Extraordinary (England/Scotland)

Other People’s Butterflies (England)

That's What She Said (England)

Loveless (England)

North America

note: I'm excluding the majority of US books here, because otherwise this section would be 3x as long as the rest combined. I am just including Canada, Alaska, Hawaii (under Oceania, above), and then books by Indigenous authors (which is all below except BLTG)

The Summer of Bitter and Sweet (Canada)

Before I Let Go (Alaska)

Elatsoe (Texas)

A Snake Falls To Earth (Texas)

Màgòdiz (postapoc US)

Godly Heathens (Georgia)

#aspec books / aspec database / tumblr masterpost

[afeelgoodblog]

The Best News of Last Week - March 18

1. FDA to Finally Outlaw Soda Ingredient Prohibited Around The World

An ingredient once commonly used in citrus-flavored sodas to keep the tangy taste mixed thoroughly through the beverage could finally be banned for good across the US. BVO, or brominated vegetable oil, is already banned in many countries, including India, Japan, and nations of the European Union, and was outlawed in the state of California in October 2022.

2. AI makes breakthrough discovery in battle to cure prostate cancer

Scientists have used AI to reveal a new form of aggressive prostate cancer which could revolutionise how the disease is diagnosed and treated.

A Cancer Research UK-funded study found prostate cancer, which affects one in eight men in their lifetime, includes two subtypes. It is hoped the findings could save thousands of lives in future and revolutionise how the cancer is diagnosed and treated.

3. “Inverse vaccine” shows potential to treat multiple sclerosis and other autoimmune diseases

A new type of vaccine developed by researchers at the University of Chicago’s Pritzker School of Molecular Engineering (PME) has shown in the lab setting that it can completely reverse autoimmune diseases like multiple sclerosis and type 1 diabetes — all without shutting down the rest of the immune system.

4. Paris 2024 Olympics makes history with unprecedented full gender parity

In a historic move, the International Olympic Committee (IOC) has distributed equal quotas for female and male athletes for the upcoming Olympic Games in Paris 2024. It is the first time The Olympics will have full gender parity and is a significant milestone in the pursuit of equal representation and opportunities for women in sports.

Biased media coverage lead girls and boys to abandon sports.

5. Restored coral reefs can grow as fast as healthy reefs in just 4 years, new research shows

Planting new coral in degraded reefs can lead to rapid recovery – with restored reefs growing as fast as healthy reefs after just four years. Researchers studied these reefs to assess whether coral restoration can bring back the important ecosystem functions of a healthy reef.

“The speed of recovery we saw is incredible,” said lead author Dr Ines Lange, from the University of Exeter.

6. EU regulators pass the planet's first sweeping AI regulations

The EU is banning practices that it believes will threaten citizens' rights. "Biometric categorization systems based on sensitive characteristics" will be outlawed, as will the "untargeted scraping" of images of faces from CCTV footage and the web to create facial recognition databases.

Other applications that will be banned include social scoring; emotion recognition in schools and workplaces; and "AI that manipulates human behavior or exploits people’s vulnerabilities."

7. Global child deaths reach historic low in 2022 – UN report

The number of children who died before their fifth birthday has reached a historic low, dropping to 4.9 million in 2022.

The report reveals that more children are surviving today than ever before, with the global under-5 mortality rate declining by 51 per cent since 2000.

---

That's it for this week :)

This newsletter will always be free. If you liked this post you can support me with a small kofi donation here:

Buy me a coffee ❤️

Also don’t forget to reblog this post with your friends.

[collapsedsquid]

A 21-year-old man who died fighting for the Russian army in Ukraine has been identified as the son of a senior official in the CIA. Michael Gloss was killed on the front line in the eastern Donetsk region in April last year, Important Stories, a Russian investigative outlet, reported. He was the son of Juliane Gallina, the CIA deputy director for digital innovation, and Larry Gloss, a US navy veteran who took part in Operation Desert Storm during the Gulf War of the early 1990s. On social media and in online chats with members of the Rainbow Family, a countercultural group that traces its roots to the activism of the 1970s, Gloss spoke of his disgust with America. He wrote on Telegram: “When I finally figured out how the US political system works, I realised that violence is an integral part of it.” On Instagram, he posted a picture of himself putting up his finger to the US Capitol. Another post showed a burning American flag. Acquaintances of the former boy scout and high school lacrosse player said he was enraged by Israel’s war in Gaza and had become an avid consumer of conspiracy theories. According to Important Stories, he told one friend that Western hegemony was fading and that the future would be a “multipolar world” dominated by the Brics nations, a line familiar from Russian propaganda. Brics is an intergovernmental group comprising Russia, India, China, Iran and several other countries.

[...] In May 2023, he wrote online: “Mum was telling me I could just come back any time. She was trying to make me collapse and call her for a ticket home.” But he said he was set on his path. He said: “I find myself more and more alive by the minute. Hungry for blood and glory. “It will be a sad day for ItthoBa’al [a name he had adopted] when the club must be passed on to the next incarnation. But as of now, I might have just incarnated in time to defeat mortality AND the military industrial complex.” When asked how he planned to defeat the latter, he said people would not believe him if he said.

[...] By Sept 5, he had enrolled in the Russian military, and an entry with Michael Alexander Gloss’s data appears in the EMIAS medical database. His address was listed as that of a medical examination room given to foreign recruits, Important Stories reported. During training for the 137th airborne regiment in the city of Ryazan, he told fellow recruits that he wanted to gain Russian citizenship so he could pursue environmental infrastructure projects in the country, Important Stories reported. Videos posted by Nepalese and other foreign recruits show Gloss smiling with his head shaved. He told “Mert”, a Rainbow Family friend, that he joined not to fight but to gain a passport. In one message, he said: “My goal in life is to build an infrastructure for the oxidation of water in a supercritical state. To put an end to environmental pollution and the diseases and deaths associated with pollution, that is: cancer, lymphoma and all the hormonal problems associated with microplastics and estrogens in water.”

[unhetalia]

this is really weak of me but I really do have to headcanon the Nations as having nothing to do with their governments and at times actively working against them because otherwise the atrocities are Not Fictional...

and anyway these beings hundreds of years old absolutely know that governments do not always have the people's best interests in mind. Do not always take care of the land. Nations believe their role is to take care of their land and their people, and maybe the older Nations tried to work with those in power in the beginning, but quickly learn their lesson.

because of this headcanon, I imagine the Nations all have 'departments' they belong to that focus on a certain issue. It would be impossible to have one individual try to have intimate knowledge of every single issue a country faces, and I love the implications this has on how much the Nations rely on each other, and how much their relationships are not reflective of human politics, because their purpose is not to reflect their people but to protect them and the land they're on.

SO finally, to the point of this post.

Here's what I think certain Nations do:

England and Russia are in charge of information gathering AKA espionage, as both have infiltrated their own governments at a very high level. Arthur is in MI6, Ivan is in the KGB-turned-FSK-turned-FSB. They're valuable assets to the rest of the world because they tend to have information on what everyone's governments are doing. Some other Nations who work in this department are Hungary, Philippines (F), Canada, Cuba, Ukraine, Scotland, Wales, Northern Ireland.

A lot of Nations work on environmental issues - Sweden, Finland and Denmark focus on governance as a way to mitigate environmental issues, while Australia, New Zealand, South Africa are focused on conservation, Brazil, Colombia, Congo focus on deforestation and air pollution, the Pacific Islands on rising sea levels and ocean pollution.

China, France, Ireland and Turkey are focused on food security - each one focuses on a specific aspect of it. China on availability, Ireland on access, France on utilisation and Turkey on stability.

Social welfare is headed by Austria and Belgium, with Spain, the Italies, Greece and Portugal focused on it.

Internal security is handled by the Germany brothers and Switzerland - this is the protection of the Nations themselves. Arranging identities, extraction of Nations who land themselves in trouble, and also the keeper of their arsenal.

America heads the research and development department that connects everything together - they develop the gadgets used by Arthur and Ivan's team, help develop technologies and conduct research focused on the environment and food security, help trial new ideas on addressing poverty, hack databases in order to help create identities for Nations. This department includes Japan, South Korea, India (F), Taiwan, Tony (not a Nation but heavily involved), Liechtenstein, Hong Kong, Belarus, Netherlands, Estonia, Mexico (F).

EDIT: I have to re-think a lot of this because I keep thinking about how very little countries there are compared to shit happening in the world and it messes with this universe a little bit. SO. WILL BE RE-WORKED.

[scotianostra]

April 28th 1742 saw the birth in Dalkeith of Henry Dundas, 1st Viscount Melville, the lawyer and politician who became the last person to be impeached in the United Kingdom.

We don't have to be proud of all our Scots in history, we also can't ignore them, I doubt anyone would say we could be proud of a man like Henry Dundas.

You wouldn’t think that a man who crushed a rebellion against the Highland Clearances and played a part in delaying the abolition of the Transatlantic slave trade by 20 years would have a memorial in Scotland’s capital – yet Henry Dundas sits atop one of Edinburgh’s tallest monuments.

Also known as the “Grand Manager of Scotland”, politician Henry Dundas, 1st Viscount Melville played a defining role in late 18th-century politics.

He was the first secretary of state for war and the last person to be impeached in the UK for embezzling public funds.

During his life he also oversaw the transportation of Thomas Muir and the Scottish radicals demanding the right to vote – a case that inspired Robert Burns to pen Scots Wha Hae – and was said to be key to the expansion of the British Empire in India and the West Indies.

Yet despite this record, the Melville Monument on which he stands atop, located in St Andrew Square in Edinburgh, simply states that he was “a dominant figure in politics for over four decades” and that “besides being treasurer to the Navy, he was also Lord Advocate and Keeper of the Scottish Signet”.

doesn’t have the most distinguished history when it comes to the slave trade, writes Andrew Learmonth. Henry Dundas wasn’t the only prominent Scot to have made huge amounts of money on the back of other people’s enslavement.

Many in Glasgow became obscenely rich due to their trade in the tobacco and sugar businesses; two industries entirely reliant on the efforts of slavery. James Ewing, former Lord Provost and MP, below, who has a memorial in the city’s Necropolis, was a slave plantation owner.

And when slavery was abolished, plenty of prominent Scots became very wealthy thanks to a ludicrously generous compensation scheme.

A database of the compensation paid out showed there were slave owners all over Scotland. Scots on the database include Colonel John Gordon of Cluny, who in 1851 forced some 3,000 of his tenants on the Outer Hebrides to emigrate to Canada, and James Cheyne, who cleared tenants from the Isle of Lismore in the 1840s and 1850s.

Read more about Dundas here, but not with pride, it is with a sense of shame.

https://historycompany.co.uk/.../henry-dundas-lofty-hero.../

[allindiadatabase]

How Can You Access the All India Students Database?

 Unlocking Opportunities with the All India Students Database

Accessing the All India Students Database can be a game-changer for educational institutions, recruiters, and businesses seeking to engage with students nationwide. This comprehensive resource offers critical insights that can transform outreach strategies and drive meaningful connections.

The Allindiadatabase includes rich data on student demographics, academic performance, and contact information. Educational institutions can use this to refine their enrollment strategies, targeting prospective students with precision. Meanwhile, recruiters can streamline hiring by quickly identifying candidates who meet specific criteria.

To access this database, begin by connecting with authorized providers or platforms that offer legitimate and compliant services. It's essential to choose a reputable source to ensure data accuracy and adherence to privacy regulations. With a trusted partner, you'll gain access to a powerful tool that can elevate your outreach, recruitment, or engagement efforts.

In conclusion, the All India Students Database isn’t just about data—it’s about unlocking smarter, more impactful ways to connect with the student community. Whether your goal is to increase enrollments or identify top talent, this resource is an indispensable asset in today’s competitive environment.

[carajkagrawal]

Get a Reliable Pan India Database 2024 for Marketing

In 2025, businesses must leverage accurate data for successful marketing campaigns. Whether reaching B2B or B2C audiences, having a Pan India database 2024 is essential. A well-structured database enables businesses to connect with potential clients efficiently, leading to higher conversions. Additionally, choosing an all India database provider ensures access to authentic data for effective outreach.

Why a Marketing Database is Essential

A high-quality database helps businesses streamline communication, increase engagement, and maximize return on investment. With a Pan India database 2024, companies can execute personalized marketing strategies that generate real results. Moreover, partnering with an all India database provider allows seamless connectivity with customers across different regions, strengthening nationwide marketing efforts.

Key Benefits of Using a Marketing Database

Targeted Outreach – A segmented database helps businesses reach the right audience at the right time.

Higher Engagement – Direct marketing via WhatsApp, email, and calls enhances customer interaction.

Improved ROI – Focused campaigns reduce unnecessary spending and increase conversion rates.

Competitive Edge – Access to verified data ensures businesses stay ahead in their industry.

Get an Authentic Pan India Database 2024

Finding a reliable all India database provider is crucial for effective marketing. Saasyto stands out as a trusted provider, offering accurate and updated data across multiple industries. Their comprehensive database ensures businesses can reach their ideal customers effortlessly.

Industry-Specific Database Solutions

Healthcare – Connect with hospitals, doctors, and pharmaceutical companies.

Education – Target students, universities, and e-learning platforms.

Retail – Promote offers to potential buyers through personalized campaigns.

Technology – Engage IT professionals and software companies.

Real Estate – Reach property buyers, investors, and agents efficiently.

Features of a High-Quality Database

A structured Pan India database 2024 provides multiple advantages for businesses. Saasyto ensures accuracy, relevance, and efficiency in every dataset they provide.

Key Features:

Comprehensive Coverage – Nationwide database for B2B and B2C marketing.

High Accuracy – Verified contact details reduce bounce rates and enhance credibility.

Manually Sorted Data – Well-organized information for improved usability.

Detailed Contact Information – Includes names, emails, phone numbers, and addresses.

Multi-Platform Integration – Enables marketing across WhatsApp, SMS, calls, and emails.

Maximizing Marketing Campaigns with a Database

1. Segmented Outreach for Better Engagement

A Pan India database 2024 allows businesses to target audiences based on demographics, location, and behavior. This segmentation ensures that marketing campaigns reach the most relevant prospects.

2. Multi-Channel Marketing for Wider Reach

Using an all India database provider, businesses can expand their reach through SMS, WhatsApp, emails, and phone calls. This approach maximizes brand exposure and enhances customer engagement.

3. Cost-Effective & High-ROI Campaigns

A well-structured database minimizes marketing expenses by focusing on high-potential leads. With a Pan India database 2024, businesses can optimize their budgets while increasing conversions.

How Businesses Can Leverage a Database for Growth

Healthcare Industry

Hospitals and pharmaceutical companies can use a Pan India database 2024 to connect with doctors, clinics, and medical suppliers efficiently.

Education Sector

E-learning platforms and institutions can utilize an all India database provider to target students and professionals for online courses and admissions.

Retail & E-Commerce

Retailers can send personalized promotions using a Pan India database 2024, improving sales and customer retention.

Technology & IT

Tech companies can rely on an all India database provider to reach startups, SMEs, and enterprises for software solutions and IT services.

Real Estate & Construction

Real estate agents and developers can use a Pan India database 2024 to market properties to buyers and investors effectively.

Boost marketing with a verified Pan India database 2024. Find an authentic all India database provider for targeted B2B and B2C campaigns.

[covid-safer-hotties]

Old News (Published Nov, 2022)

Also preserved on our archive

Pro-Tip: All covid-19 strains are capable of immune escape from both vaccination and acquired immunity from infection! Mask up to prevent the spread of covid and further mutation toward immune escape!

By Alice Park

New lab data suggest that vaccines and prior infections may not offer enough protection against several new COVID-19 variants cropping up in the U.S. and around the world.

Dr. David Ho, director of Columbia University’s Aaron Diamond AIDS Research Center (ADARC), and his team reported the results from a set of studies at an ADARC symposium. They showed how well some of the latest variants—BQ.1, BQ.1.1, XBB, and XBB.1, which were all derived from Omicron—are evading both vaccine-derived and infection-derived immunity.

These new variants all have mutations in the region that binds to cells and infects them, which means that they’re highly transmissible, as prior Omicron variants were. BQ.1 is growing steadily in France, according to the public database of SARS-CoV-2 variants GISAID. By mid-November, European health officials expect the variant to account for 50% of cases in Europe, and to become the dominant strain in that region by early 2023. XBB is growing quickly in Singapore and India. Both variants have spawned new strains that have each picked up an additional mutation to create BQ.1.1 and XBB.1. As of early November, BQ.1 and BQ.1.1, combined, now make up about 35% of new cases in the U.S.

Other studies have found similar drops in antibody protection against BQ.1 among vaccinated people. But Ho’s group conducted what is likely the most comprehensive look to date at BQ.1, BQ.1.1, XBB, and XBB.1, and how existing immunity—from the original mRNA vaccines, the new Omicron boosters, and natural infections—stands up to them. Scientists took blood sera from 88 people in five groups (below) and exposed it to the four variants in the lab. Here’s what they found:

Fully vaccinated and once-boosted people (three total shots of the original mRNA vaccines) had 37- and 55-fold lower neutralization against BQ.1 and BQ.1.1, respectively, than they did against the original SARS-CoV-2 virus, and about 70-fold lower neutralization against XBB and XBB.1. Fully vaccinated and twice-boosted people (four total shots of the original mRNA vaccines) had 43- and 81-fold lower neutralization against BQ.1 and BQ.1.1, respectively, than they did against the original virus, and 145- and 155-fold lower neutralization against XBB and XBB.1, respectively. Fully vaccinated and twice-boosted people (three shots of the original vaccine plus one Omicron booster) had 24- and 41-fold lower neutralization against BQ.1 and BQ.1.1, respectively, than they did against the original virus, and 66- and 85-fold lower neutralization against XBB and XBB.1, respectively. Fully vaccinated people who had received the original booster and who had been infected with BA.2 had 20- and 29-fold lower neutralization against BQ.1 and BQ.1.1, respectively, than they did against the original virus, and 103- and 135-fold lower neutralization against XBB and XBB.1, respectively. Fully vaccinated people who had received the original booster and who had been infected with BA.4 or BA.5 had 13- and 31-fold lower neutralization against BQ.1 and BQ.1.1, respectively, than they did against the original virus, and 86- and 96-fold lower neutralization against XBB and XBB.1, respectively.

The results show that people who had been infected with BA.2, BA.4, or BA.5 generally experienced the smallest drop in neutralizing antibody levels against against BQ.1 and BQ.1.1. But people who had three doses of the original vaccine and one Omicron booster produced only slightly better neutralizing antibody protection against XBB and XBB.1 than those who received three doses of the original vaccine. Public-health experts say that while vaccines may wane in efficacy against newer variants, they continue to protect people from severe COVID-19. There is early evidence that vaccine-induced immunity may also produce a broader range of virus-fighting antibodies over time.

Read More: BQ.1, BQ.1.1, BF.7, and XBB: Why New COVID-19 Variants Have Such Confusing Names

Still, these results are a reminder that vaccines and drug treatments need to evolve with the virus. “These new variants are extremely good at evading our antibodies and are very likely to compromise the efficacy of our vaccines,” says Ho. They may also dodge the available antibody-based treatments for COVID-19, he says. The National Institutes of Health’s COVID-19 Treatment Guidelines currently only include one monoclonal antibody therapy, bebtelovimab, because the virus has evaded all of the previously authorized antibody treatments. But in an October update, NIH scientists acknowledged that the “subvariants BQ.1 and BQ.1.1 are likely to be resistant to bebtelovimab.” The drug is therefore only recommended if people either can’t take the antiviral drugs Paxlovid or remdesivir, or if these medications aren’t available. The virus can evade these treatments as well, but they remain the first line of defense against severe SARS-CoV-2.

The good news is that in places where these variants are spreading, they do not seem to be linked to more severe COVID-19 disease—measured by hospitalizations and deaths—than other Omicron iterations. Still, public-health experts say a spike in infections could still strain health resources, especially as other respiratory infections, including influenza and RSV, also gain momentum. The combination of several circulating infectious diseases could mean more illness overall, and, in turn, more people who might experience severe disease and require intensive medical care.

The rise of BQ.1, BQ.1.1, XBB, and XBB.1 points to the fact that when it comes to immunity, the virus may always be one step ahead, especially with respect to vaccines. “I would start to make these vaccines, and start to test them in animals,” says Ho. Even if those efforts began now, it’s possible they may still lag behind the virus and the new mutations it continues to gain. That’s why researchers are working on developing vaccines that would be more universally applicable to a range of different coronaviruses, which could shorten the amount of time it takes to build up a vaccinated population’s immunity.

[qs-23]

Exploring the Limitless Possibilities of the All India Database

The All India Database offers unparalleled opportunities for businesses and researchers looking to unlock valuable insights. With comprehensive data on demographics, economic trends, and consumer behavior, this database provides the foundation for informed decision-making and strategic planning. Utilizing this wealth of information can help identify new market opportunities and optimize business strategies.

In addition, the All India Database can significantly enhance operational efficiency by offering detailed insights into regional and sectoral trends. By integrating this data into your business processes, you can streamline operations, tailor marketing efforts, and make data-driven decisions that propel your organization forward.

Read more:

[monarch-afterdark]

Titan History: Scylla

Welcome once again to Monarch: After Dark, the digital gateway between you and the organisation dedicated to understanding and navigating this troubled new world we live in.

While our inquiry into Janos Biotech continues, we return to the regularly scheduled "Titan History" series, where we break down all you need to know about the creatures we now share our world with. For today's communication, we look to the most recent Titan crisis and examine one of the casualties; the Lovecraftian scavenger, Scylla.

(Pictured above: Scylla rampaging through Rome, prior to being confronted and executed by Godzilla, circa. 2027)

Monarch Database File: Scylla

Monarch Designation: Titanus Scylla

Height: 341 feet

Weight: 20,000 tons

Nature: Bio-Corrosive

Behavioural Classification: Destroyer

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A colossal cephalopod Titan that appears to have crawled out from the depths of the Cthulhu Mythos, Scylla is among one of Monarch's more recent discoveries, noted as 'Titan 024' in our database. Her discovery was recent enough that, during the construction of Monarch Outpost 55, a proper containment field for Scylla was unable to be constructed. Some of the outpost's operatives erroneously believed she was dead when they found her dormant in Arizona.

Scylla is known to us as a Titan scavenger, able to break down the carcasses of deceased Titans and convert the nutrients into a lethal waterborne bacteria. This ability led to the implementation of new protocols for Monarch's pathology teams when cleaning and disposing of Titan remains. She can also emit an incredibly dense fog-like pollutant, which she uses to feed on radiation sources or cover her while she evades an attacker, and can emit liquid nitrogen from her body. The latter ability in particular has been cited for cooling down the Antarctic ice and stabilizing global sea levels.

Scylla is also surprisingly intelligent, able to take the wreckages of ships and craft them into temporary shells for her body, and is remarkably agile in her movements, enabling her to take on opponents such as Godzilla with ease.

(Pictured above: The Moai statues of Easter Island. It is believed by Monarch these were built by the Rapa Nui people to ward off Titans like Scylla)

Like with most Titans, not much is known about Scylla's activities prior to 2019 outside of what mythological records allow. It is known that, at some point, Scylla made landfall on Easter Island. Feared by the Rapa Nui people, they erected the Moai status as megalithic scarecrows to deter her, and presumably other Titans as well.

When Scylla was awakened by Monster Zero in 2019, she erupted from beneath Monarch Outpost 55 and made her way to Arizona's capital Phoenix, where she rampaged through the city. She was pacified by the ORCA device's activation in Boston, and was among the few Titans present to witness Godzilla become the new Alpha, bowing down to him as he roared into the sky.

Between this and her next known sighting, Scylla enjoyed a deal of popularity among humanity once Monarch's record of her went public, even becoming a trending topic on social media platform Twitter once her Greek origins were confirmed.

(Pictured above: Artistic rendition of Scylla engaging the United States Coast Guard and Godzilla over possession of a nuclear warhead, circa. 2020)

Around the end of 2020, Scylla appeared off the coast of Savannah, Georgia in search of food. Her hunger led her to a discarded nuclear warhead, which she fought with the US Coast Guard for possession of. Godzilla arrived shortly after and successfully drove Scylla away after a short brawl. She then made her way to a frozen lake at the tip of South America, claiming it as her new territory. Like with all other Titans, Scylla then returned to dormancy, seemingly under Godzilla's instruction.

She did not stay dormant, however. In 2027, Scylla was lured to the Kudankulam Nuclear Power Plant in India by a reactor beacon created by Skull Island trophy hunter Raymond Martin, who (as Monarch later discovered) wanted to use her to occupy Godzilla's attention so he could proceed with his plans for Hollow Earth. After feeding on the radiation there, she would travel to other locations around the world and feed there, Godzilla always one step behind her.

Scylla attacked the United Kingdom Nuclear Labs in Preston and the Aviano Air Base in Italy, feasting off whatever she could find. Her ravenous feeding had caused her to cease cooling the planet's oceans, and Monarch instead found that she was heating the areas she attacked, causing damage to the ozone layer. After an attempted trap by Monarch failed, she was finally cornered by Godzilla in Rome and killed by a point-blank blast of his atomic breath following a short skirmish.

(Pictured above: An X-Ray scan of Scylla, part of a compiled bioacoustic database Monarch has on all Titans, circa. 2019)

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And there you go! While Scylla's passing means we may not be able to learn more about her, unless new data is found or another of her species emerge in the future, we do take some pride in knowing some people out there came to embrace Scylla, rather than fear her as most would.

Until next time,

Monarch: After Dark