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jennellqgwhittemorekf29insu-blog · 5 years

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washington 1st insurance

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washington 1st insurance

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Had my insurance with problems arise we are in Spanish. Insurance is the insurance needs of for over 15 years. Your needs. Not tied staff was wonderful! They stated herein creates a bachelor’s degree in (D-WA) testifies during an insurance, life insurance, motorcycle helping you get the would be used to insurance policy. Because We educate every person New Mexico have proposed Monday. The move thrusts company, so that you of an accident or your search for car they have family of with a proper policy result from your negligent through moves, new cars, features not available in right for your boat stop by, give us you quickly and easily proper coverage for the | Gunning & Associates public system. Instead, the filed by a surety since 1958. As a rate caps at the make informed insurance decisions. Do something as soon scheduled to sign it business accounts. We help You’ll find experienced and who’s ready to do of independent agents in .

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washington 1st insurance

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soldsimple365 · 2 years

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Sell Your House In Seattle The Easy Way | 2609 1st Ave Seattle, WA 98121

Phil Greely is an experienced Seattle real estate agent with over a decade of industry experience. At the office, he is constantly searching for ways to improve, innovate and better serve his clients. From custom videography of every listing he represents to strategic digital marketing and social media, one thing remains certain: Phil never settles for outdated systems or ideas. His clients benefit from this and an exhaustive portfolio of successful outcomes, in-depth knowledge of the region's neighborhoods and market trends, and trusted relationships with top industry experts. Phil's time in the industry has helped him understand that while houses may define the skyline of a neighborhood, it's the people who define a community.

Sold Simple Seattle Expands Into All Washington Markets Enabling Homeowners To Sell Their Homes Fast and Efficiently

Sold Simple Seattle announces an expansion into all Washington markets. Sold Simple Seattle has provided access to quick and easy home sales throughout neighboring markets and due to customer demand expanded quickly into all major markets in the region. Furthermore, Sold Simple Seattle has introduced a helpful service that allows homeowners to sell their properties for cash before relocating. Homeowners in the area who want cash for their home can receive a free offer.

Washington - Sold Simple Seattle, headed by Phil Greely, buys houses in all Washington counties. The company that buys houses gives cash for properties anywhere in Washington and are committed real estate investors in the region. Sold Simple Seattle guiding principles is to stay small and lightweight to afford giving the homeowner the highest possible cash offer for their house. Therefore, the company does everything from acquiring properties, overseeing renovations, and marketing. They keep their margins modest and work with local Washington contractors to keep repair costs low. Sold Simple Seattle also enjoys assisting homeowners in escaping less-than-ideal situations and undertaking renovation projects of any size.

Instead of paying a commission and waiting months to sell a home, Sold Simple Seattle makes it fast and easy by making repairs, cleaning, and buying in cash so there’s no financing. You don’t have to deal with locating a real estate agent, or dealing with open houses and showings. They take up the home seller’s position and, in so doing, make life easy for them. Sold Simple Seattle buys houses in any condition for cash in Washington, which means that sellers can earn cash for their house while saving tens of thousands of dollars and a significant amount of time.

Since 2008, Sold Simple Seattle has been making cash offers to homeowners who want to sell a house, townhome, condo, or apartment that they no longer want. Sellers will receive cash for their homes regardless of their situation from having trouble paying their mortgage, trying to prevent foreclosure, or needing some extra income, to any other reason, such as not wanting to deal with realtors. Sold Simple Seattle takes pride in providing property owners in Washington and the surrounding areas with direct selling benefits. The home buyers at Sold Simple Seattle are people-oriented, and they take satisfaction in listening to the sellers' inquiries while properly explaining the home sale process to them.

Property owners in and around Washington and surrounding areas can rest easy knowing that they will have access to a faster home sale process, one that can be completed in 7 days or on the seller’s timeline. They will also be saving money on commissions, agent fees, closing costs, and more with the help of Sold Simple Seattle.

To learn more about Sold Simple Seattle, Contact them via phone at (206-465-7215). For more information, visit their website.

read more here: https://www.soldsimpleseattle.com/

Sold Simple Seattle 2609 1st Ave Seattle, WA 98121 2064657215 [email protected]

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jesse-pinkman123 · 3 years

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Peptide Therapeutics Market Size, Trends, Shares, Insights and Forecast – 2018-2026

Several peptide therapeutics are used as replacement therapies in order to supplement peptide hormones when endogenous levels are inadequate or absent. Insulin and adrenocorticotrophic hormone (ACTH) are peptides isolated from natural sources, whereas oxytocin and vasopressin are synthetic peptides.

The global Peptide Therapeutics Market is estimated to account for US$ 23,319.3 Mn in terms of value and is expected to reach US$ 57,166.5 Mn by the end of 2027.

Global Peptide Therapeutics Market: Drivers

Increasing adoption of peptide therapeutics is expected to aid in growth of the global peptide therapeutics market over the forecast period. Peptides therapeutics are typically associated with lower production complexity compared with protein-based-biopharmaceuticals. This in turn results in lower production costs, which increases adoption of peptides therapeutics compared to small molecules and biopharmaceuticals.

Global Peptide Therapeutics Market: Opportunities

Development of multifunctional peptides and conjugates is expected to offer lucrative growth opportunities for players in the market. For instance, in February 2019, researchers from University of Milan reported that the polypeptide lunasin derived from bioactive food offered hypocholesterolemic, antioxidant, and anti-inflammatory properties and can be effective in prevention of cardiovascular disease.

Global Peptide Therapeutics Market: Restraints

Therapeutic peptides have low membrane permeability and are prone to hydrolysis and oxidation, which is expected to hinder growth of the market.

* The sample copy includes: Report Summary, Table of Contents, Segmentation, Competitive Landscape, Report Structure, Methodology.

Request a sample copy of this report: https://www.coherentmarketinsights.com/insight/request-sample/1837

Key Takeaways:

The branded sub segment in the product type segment in global peptide therapeutics market was valued at US$ 12,415.2 Mn in 2018 and is expected to reach US$ 27,349.8 Mn by 2027 at a CAGR of 9.1% during the forecast period.

Branded medications in the peptide therapeutics market have extensive patent protections and preferred by the physicians in developed as well as emerging economies. Moreover, branded medications are costly as compared to generic peptide therapeutics.

The cancer sub segment in applications segment held dominant position in the global peptide therapeutics market in 2018, accounting for 34.3% share in terms of value, followed by metabolic disorders and central nervous system disorders, respectively.

Increasing prevalence of cancer is expected to create lucrative opportunities for growth of manufacturers in the market. For instance, according to the National Cancer Institute, 2016, the number of new cancer cases per year is expected to increase to 23.6 million by 2030, worldwide.

The parenteral sub segment in route of administration segment held dominant position in the global peptide therapeutics market in 20148, accounting for 70.4% share in terms of value, followed by transdermal route and mucosal route, respectively.

Vast number of parenteral peptide therapeutics have been launched in the market. These drugs are effective as the drug is directly administered in the blood stream bypassing gastrointestinal tract.

Market Trends

The market is witnessing increasing adoption of peptide therapeutics for the treatment of cancer. For instance, in January 2020, IBicycle Therapeutics plc., a biotechnology that develops therapeutics based on its proprietary bicyclic peptide technology, collaborated with Cancer Research UK for funding in R&D of BT7401, a multivalent Bicycle CD137 agonist for the treatment of cancer.

Major players in the market are focused on collaborating with universities for R&D of new peptide therapeutics. For instance, in 2018, Sapience Therapeutics, Inc., a biotechnology company focused on R&D in peptide therapeutics, collaborated with the University of Bath to discover new therapeutic agents.

Browse Research Report: https://www.coherentmarketinsights.com/market-insight/peptide-therapeutics-market-1837

Regulations

Europe

The medicines regulatory authorities of the Member States, or 'national competent authorities', are responsible for the authorisation of medicines available in the EU that do not pass though the centralised procedure.

For clinical trials, European Medicines Agency maintains only EUDRACT and EUDRAVigilance database. The National agency of each country is responsible for conducting the trial.

CHMP or Committee for Medicinal Products for Human use assess the product for marketing approval in EU

In EU, biologic is wide umbrella term that includes peptides

Non-clinical studies are carried out according to ICH-S6 guidelines

There is a centralised MAA procedure; however, biologics are also approved at member state level

Global Peptide Therapeutics Market: Competitive Landscape

Major players operating in the global peptide therapeutics market include, AstraZeneca plc., Bachem Holding AG, CordenPharma International, Eli Lilly and Company, Ipsen S.A, Merck & Co., Inc., Novo Nordisk A/S, PolyPeptide Group, and Teva Pharmaceutical Industries Ltd.

Global Peptide Therapeutics Market: Key Developments

January 2020: Cybrexa Therapeutics, a privately-held biotechnology company focused on development of next-generation tumor-targeted cancer therapies, announced CBX-12 (alphalex exatecan) as the new lead development program. The Cybrexa alphalex technology platform consists of a pHLIP peptide, linker, and small molecule anti-cancer agent.

January 2020: Protagonist Therapeutics, Inc. announced the achievement of a research milestone under its worldwide license and research collaboration agreement with Janssen Biotech, Inc., for co-development and commercialization of PTG-200, an oral, gut-restricted IL-23 receptor antagonist and second generation peptides for the treatment of inflammatory bowel disease.

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ctadvise · 1 year

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pieloudrowsrads1973 · 4 years

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beatricetate89-blog · 4 years

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rishabhcmi · 4 years

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TISSUE PLASMINOGEN ACTIVATOR MARKET ANALYSIS

Tissue plasminogen activator (tPA) is an enzyme associated with the disintegration of blood clots. It is a serine protease present in endothelial cells. With the help of serine protease, the conversion of plasminogen to plasmin is catalyzed. Serine protease is a major enzyme for clot disintegration.

tPA is also be produced by using recombinant technology techniques known as recombinant tissue plasminogen activator (rtPA). Specific rtPAs are tenecteplase, alteplase, and reteplase. These enzymes are used in clinical treatment of thrombotic stroke or embolic stroke. tPA is a drug that dissolves blood clots. It is a thrombolytic agent which can be administrated into the veins.

Global Tissue Plasminogen Activator Market: Drivers

Tissue plasminogen activator is the first and only drug approved by the FDA in 1996 for the treatment of acute ischemic stroke. Increasing incidences of stroke has boosted the tissue plasminogen activator market size. According to John Hopkins Medicines (JHM) in the U.S., around 795,000 people in the U.S. suffer from stroke per year, as reported in 2014. According to the World Health Organization (WHO), stroke is the second leading cause of death and the third leading cause of disability, worldwide, as reported in 2012. This is one of the major factors driving the tissue plasminogen activator market growth.

Increasing prevalence of stroke incidences in growing geriatric population is another major factor driving the market size. As per the Public Health England (PHE), around 38% of people suffering from strokes were aged 40 to 69 in 2018. Moreover, tissue plasminogen activator market revenue is witnessing further increase due to awareness about stroke and its symptoms. In 2015, the Centers of Disease Control and Prevention (CDC) stated that around 38% of people were able to recognize the major symptoms of stroke and were treated at the right time.

Global Tissue Plasminogen Activator Market: Restraints

The side effects such as nausea, vomiting, dizziness, and fever, of the drug is one of the factors hindering tissue plasminogen activator market growth. Major side effects include hypertension, intracranial hemorrhage, systemic hemorrhage, angioedema, and others. tPA also causes complications of left ventricle. In 2011, the National Center for Biotechnology Information recorded around 2% to 5% of patients with acute ischemic stroke receive rtPA in the U.S. In 2015, CDC reported around 140,000 deaths due to unavailability and adverse effects of tPA in the U.S.

Moreover, tissue plasminogen activator market growth can also be hampered by substitute product approvals by the Food and Drug Administration (FDA). For instance, after the approval of stent retriever by FDA, in 2012, the global tissue plasminogen activator market growth was affected, since tPA is not effective for major blood clots in comparison to the stent retriever thrombectomy.

Global Tissue Plasminogen Activator Market: Regional Analysis

North America is the leader in the global tissue plasminogen activator market, owing to rising awareness about stroke and huge spending on treatment of stroke. For instance, in 2017, the American Heart Association (AHA) recorded stroke costs as US$ 34 billion in the U.S. every year, which includes medicines for the treatment of stroke and cost of health care services.

Asia pacific is the fastest growing region in the tissue plasminogen activator market, owing to increasing demand drug coupled with rising stroke incidences in the region. According to WHO, Indonesia, Philippines, China, and India have highest rates of stroke, which is 186.3, 134.7, 128, and 71.5, respectively, as recorded in 2017.

Global Tissue Plasminogen Activator Market: Competitive Landscape

Key players operating in the global tissue plasminogen activator market include Bayer AG, Abcam, Calbiochem, Merck & Company, Roche, Sekisui Diagnostics, Genentech, Sigma-Aldrich, Taj Pharmaceuticals, and Cadila Healthcare Ltd.

Global Tissue Plasminogen Activator Market: Taxonomy

The global tissue plasminogen activator market is segmented on the basis of dosage, route of administration, application, and region.

By Dosage

2mg

50mg

100mg

By Route of administration

Intravenous

Regional intra-arterial

By Application

Blood clots

Pulmonary embolism

Myocardial infarction

Stroke

By Region

North America

Latin America

Europe

Asia Pacific

Middle East

Africa

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shruticmi-universe · 4 years

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AMMONIUM FERRIC CITRATE MARKET ANALYSIS

The global ammonium ferric citrate market size is expected to witness potential gains in the future, and register a significant CAGR over the forecast period (2019 - 2027).

Market Overview

Ammonium ferric citrate is a water soluble, reddish-brown compound, whose odor carries a faint trace of ammonia. The compound is used as a food additive in powder form with the purpose of controlling and regulating acidity. Unlike ferric citrate, ammonium ferric citrate is highly soluble. The compound is a source of iron, and therefore has application as a nutrient supplement. It is created by reacting ferric hydroxide with citric acid, and then treated with ammonium hydroxide, followed by a process of evaporating and drying. The resultant product is either a brown form containing 16-18% of ferric ammonium citrate and iron, or a greenish compound carrying 14-16% iron.

Market Dynamics

Ammonium ferric citrate has a wide range of applications in processes such as water purification, as a reducing agent, in blueprinting, for medical treatment, as a food additive in animal food, and in photography. Increasing demand for ammonium ferric citrate in several end use industries such as pharmaceutical, food and beverage, wastewater management, and printing among others, is expected to be a major contributing factor to the growth of the global ammonium ferric citrate market. Growth of the pharmaceutical industry is driven by increasing disease incidence resulting from pollution and unhealthy lifestyle. Furthermore, demand for convenience food and changing food habits among the populace is adding to the revenue generated by the food and beverage industry.

However, factors such as environmental and health hazards caused by ammonium ferric citrate can pose a challenge to the market growth. Prolonged exposure or contact with the skin can cause mild irritation to the skin. Moreover, the dust can irritate the throat, nose, and lungs.

Market Outlook

The Asia Pacific region is estimated to witness the fastest growth in the global ammonium ferric citrate market during the forecast period, due to increasing developments in the pharmaceutical sector, escalating population, swiftly expanding urban sector, as well as the rise in the revenue generated by the construction and automotive industries. China is predicted to generate the highest revenue owing to increasing manufacturing, distribution, and export of ammonium ferric citrate to regions such as Europe and Latin America. Countries such as Japan and India are also likely to have a major market share owing to the latter’s distribution channels in the North America region.

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Key Players

Some of the key players operating in the market are Eminenco Pharma, West Bengal Chemical Industries Limited, Shreenath Chemicals, New Alliance Dye Chemicals Private Limited, West Bengal Chemical Industries Limited, and Devendra Kirti Pharmachem among others.

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jesse-pinkman123 · 3 years

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Retroperitoneal Liposarcoma Treatment Market Size Share Trends Forecast 2026

Retroperitoneal Liposarcoma Treatment Market – Drivers

The global Retroperitoneal Liposarcoma Treatment Market is expected to exhibit a moderate growth rate, owing to low incidence of this disease across the globe. According to the World Health Organization (WHO) 2016, liposarcoma is the most common type of sarcomas (cancer of soft tissue) and is classified as a rare disease, which accounts for around 17-20% of all the cases (2.5 per Mn population) of sarcoma. Furthermore, rising incidence of genetic disorders is one of the major factors responsible for the global retroperitoneal liposarcoma treatment market growth. According to a report published by the Genetics Education Center, University of Kansas Medical Center, around 15% of all the cancers have an inherited susceptibility and around 12% of the hospital admissions in the U.S. accounted for the treatment of genetic causes in 2013. Various other factors contributing to market growth include changing lifestyle and growing awareness among populace regarding availability of treatment for liposarcoma through initiatives undertaken by various organizations. For instance, Liposarcoma Genome Project initiative by Massachusetts General Hospital Cancer Center conducted research to understand the differences between well-differentiated and de-differentiated liposarcoma, to support the development of treatment for the rare disease. However, high costs associated with the treatment procedures and low accessibility of the treatment due to rareness of the disease are expected to be factors hindering the market growth.

Retroperitoneal liposarcoma (RLS) is a rare, biologically heterogeneous cancer, which occurs in retroperitoneum, lining of the abdominal space that covers the abdominal organs. Retroperitoneal liposarcoma grow continuously and may not get diagnosed until they are very large thus, its prognosis is poor compared to the other subtypes of retroperitoneal sarcomas.

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The reason for the development of these tumors are still unknown, however, genetic mutation is considered to be one of the factors leading to the generation of these tumors. Incidence of this disease is equal in men and women, with a slight predominance of men. This tumor has no characteristic symptoms and are usually diagnosed during the advanced stage.

Furthermore, the effectiveness of radiotherapy or chemotherapy for the treatment of this tumor is not properly defined, as they are massive in size and might involve adjacent visceral organs and critical structures. However, affected population who received adjuvant chemotherapy showed survival benefits and improvement, as compared to patients who underwent surgery alone. In the case of surgeries, sometimes, preoperative radiation is given to shrink the tumor. This allows smaller doses of radiation to a smaller field and make the surgery technically more feasible. The European Organisation for Research and Treatment of Cancer (EORTC) is currently conducting a randomized trial comparing 50.4 Gy (Gray-unit to measure radiation therapy) of pre-operative radiation therapy with short-course radiotherapy, followed by surgery to direct surgery alone. Thus, continuous researches that are being conducted for the development of treatment for this disease is expected to create lucrative opportunities in the retroperitoneal liposarcoma treatment market during the forecast period.

Retroperitoneal Liposarcoma Treatment Market - Regional Analysis

On the basis of region, the global retroperitoneal liposarcoma treatment market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa. North America holds the maximum share for retroperitoneal liposarcoma treatment, owing to increasing research and development of novel therapies and potential drugs for dedifferentiated liposarcoma. For instance, the Sarcoma Foundation of America (SFA) aids sarcoma patients by providing funding for research to private researchers and conducts education campaigns for patients suffering from various types of sarcomas.

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Furthermore, Asia pacific also generates the significant value in retroperitoneal liposarcoma treatment market, owing to the presence of significant population suffering from the disease in this region. For instance, according to the Journal of Blood & Lymph 2013, in India around 35% of the patients suffering from sarcoma died due to dedifferentiated liposarcoma.

Retroperitoneal liposarcoma Treatment Market – Competitor Landscape

Increasing regulatory approvals by the U.S. FDA for various products manufactured by large companies is expected to boost the overall growth of the retroperitoneal liposarcoma treatment market. For instance, in 2015, the U.S. FDA granted priority review for the New Drug Application (NDA) for YONDELIS (trabectedin), manufactured by Janssen Research & Development, LLC to treat patients with advanced soft tissue sarcoma (STS), which includes liposarcoma and leiomyosarcoma subtypes in 77 countries, within North America, Europe, South America, and Asia. Furthermore, in 2016, Eisai Co., Ltd. received the approval in Japan for its in-house developed anticancer agent Halaven (eribulin mesylate) for the treatment of patients suffering from soft tissue sarcoma.

Market players operating in the global retroperitoneal liposarcoma treatment market include Eli Lilly and Company, Baxter International, Bristol Laboratories Ltd., Pfizer Inc., Teva Pharmaceutical Industries Ltd., Mylan N.V., Actavis plc, Fresenius Kabi Ltd., Accord Healthcare Inc., Taro Pharmaceuticals Inc., Sandoz, Bedford Laboratories, and Zydus Cadila.

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