#Celastrol

[bpod-bpod]

Attacking Arthritis

Rheumatoid arthritis (RA) causes painful inflammation and damage of joints, perpetrated by cells called inflammatory macrophages and osteoclasts. In mice with RA-like disease, researchers targeted these cells for destruction with nanoparticles covered with anti-cancer drug celastrol. They also tested adding other molecules to the nanoparticles, including molecules to better target the cells for destruction and molecules that react with an enzyme present at high levels in inflamed joints. A month after injecting the different nanoparticles into the bloodstream of arthritic mice, ankle joints were imaged using micro-CT (pictured) and compared with healthy and untreated arthritic joints (top row, first and second). Of the different nanoparticles, the ones attached to molecules for better targeting of the cells and molecules that react with enzymes in inflamed joints produced the healthiest bones (bottom, right) with increased bone density and reduced damage. This makes them the frontrunner as a candidate for RA treatment.

Written by Lux Fatimathas

Image from work by Caifeng Deng and colleagues

Sichuan University, Chengdu, China

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Nature Communications, April 2021

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[neurosciencenews]

Discovery of a drug to rescue winter depression-like behavior Fish model study found a potential target to treat seasonal affective disorder (SAD). Researchers implicated NRF2 in seasonal depression and reported celastrol may help in the treatment of SAD.

[tumb11]

Europe (2022) Smart Street Lighting Market Future Scope, Demands and Projected Industry Growths to 2030

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[captainhankquinlan]

UTSW study finds potential strategy for fighting obesitySource Newsroom: UT Southwestern Medical Center

Newswise — UT Southwestern scientists may have identified a method of safely mimicking the weight-loss benefits of a plant compound that – despite its harmful side effects – hold critical answers to developing therapies for obesity. Celastrol, derived from the root extracts of a white-flowered plant in China, has drawn increased attention in recent years after studies showed it can both prevent…

[pharmascalabisonline]

Ducray Keracnyl Glycolic+ Creme 30ml

Ducray Keracnyl Glycolic+ Creme 30ml

Ducray Keracnyl Glycolic+ Creme 30ml Ducray Keracnyl Glycolic+ Creme 30ml, desobstrui os pontos negros e suaviza a textura da pele. VANTAGENS PROMOVE O DESAPARECIMENTO DE BORBULHAS E PONTOS NEGROS: Graças à sinergia patenteada* de Celastrol e Mirtacina®, este creme atua sobre todos os fatores que causam manchas e pontos negros e reduz o excesso de sebo INGREDIENTE ESFOLIANTE O ácido glicólico…

[natural-herb-ingredients]

Tripterygium Wilfordii Thunder God Vine Root Extract Powder HPLC 98% Celastrol Tripterine. #nutrition #herbfactory #spicesfactory #herbingredientswholesale #foodmanufacturing #foodtech

[biomedgrid]

Biomed Grid | Protective Effect of Medicinal Plants on Neuron Degeneration Diseases and Controversial Predictive Diagnosis

Abstract

Neuron degenerations resulted from chronic exposure of chemicals, environmental pollutions, drugs and pesticides. Many diseases of neuron degenerations prediction still so difficult as it occurs in advanced age in animal or human and even advanced technology and recent trial of biomarkers for diagnosis of neuron degenerations still controversial. Protective herbal plants help in prevention of neuron degeneration diseases or delay its occurrence through antioxidant mechanisms. Recently, tau and tubulin protein expression could explore the future occurrence of neurogenerative diseases in human.

Keywords: Neuron Degeneration, Biomarkers, Albino Rats

Introduction

Neuron degenerative diseases are more common in developed and developing countries and occur all over the world due to death of neurons [1-3]. The incidence of neuro-degenerative diseases expected to increase nearly 131.5 million in 2050 [1,2].

Figure 1:Show different etiology of neurodegenerative diseases.

The etiological causes of neuron degenerative diseases were varied from heavy metals exposure like ammonium [4] drugs [5] or genetic susceptibility [6] and toxic agent like carbon monoxide [3]. Also, the scientist is investigating different possible causes of secondary neuron degeneration resulting from environmental factors, biochemical malfunctions as metabolic and vascular parameters, type II diabetes mellitus and immune disorders [7] (Figure 1).

The mechanism of neuron degeneration still obscure even there is one accepted theory about neurotoxicity of Acetylcholinesterase that may play a role in the development of neuronal degeneration observed in Alzheimer’s disease [8] and evidence by potential role of cholinesterase inhibitor (ChI) in improvement of cognitive function and decrease the risk of falls in patients with parkinsonism [9].

The incidence of neurodegenerative disease varied between individuals and there is no predictive measurable parameter except some trail about serum biomarkers like tau protein [10]. Also, integrins are play important role pathophysiology of many brain diseases, such as epilepsy, and consider a potential target for the discovery of new drugs for neurological disorders [11,12] different biomarkers are currently being studied in Alzheimer disease and other neurodegeneration diseases such as cerebrospinal fluid (CSF) Aβ, tau, phosphorylated tau and the other neuronal proteins, PET tracers for Aβ, tau and glucose uptake, and MR measures of brain diseases [3-15]. Interestingly, phenylalanine hydroxylase could also be a biomarker of neurodegenerative disease [16] (Figure 2).

Figure 2: Show biomarker for prediction of neurodegenerative diseases.

The only promising in prevention and delay neurodegenerative diseases are many herbal plants that have been studied like Nigella sativa (Khazdair, 2015), moringa olifera [17] and many Plants-derived natural products used in the treatment of neurological diseases [8]. The ethanol extract of Alchemilla vulgaris and Filipendula ulmaria were used as acetylcholinesterase and tyrosinase inhibitor for treatment of neurodegenerative diseases in human [19]. Notably, there many medicinal plants have neuroprotective effects studied before like Ashwagandha, Baccopa monnieri, Centella asiatica, Ginseng, Ginkgo biloba, and active principals that extracted from plants as celastrol, curcumin , flavonoids, lycopene, resveratrol, sesamol, and trehalose characterized by antioxidant and antiapoptotic neuroprotection effects [20] (Figure 3).

Figure 3:Show biomarker for prediction of neurodegenerative diseases.

Medicinal plants used in traditional medicine along with their extracted phytochemicals have various neuro-pharmacological pathways as modulation of transcription, transduction and intracellular signaling pathways including ERK and p38, with up regulation of anti-inflammatory cascades, anti-apoptosis and antoxidative stress associated pathways, all of them have essential role in the preventive and protection effects of the plants in neurodegenerative diseases [21,22].

Future Highlights

The causes of neurodegenerative diseases remain controversial. The use of plants medicine has enhanced a lot of interest for their therapeutic potential effects for many decades. In future, the benefit of phytochemicals on neurodegenerative diseases treatments due to their anti-apoptotic, anti-inflammatory, anti-oxidative and anticholinesterase activities. The rational of this review to investigate complex of predictive diagnosis of neurodegenerative diseases and possible protective agents as medicinal plants.

Read More About this Article: https://biomedgrid.com/fulltext/volume2/protective-effect-of-medicinal-plants-on-neuron-degeneration-diseases.000599.php

For more about: Journals on Biomedical Science :Biomed Grid

[advancedneurosurgery]

How celastrol sensitizes brains to leptin, curbing hunger and obesity https://ift.tt/2C24EaM

[solarpanels21blog]

How celastrol sensitizes brains to leptin, curbing hunger and obesity https://ift.tt/2C24EaM

[rnomics]

IJMS, Vol. 19, Pages 2293: The Micro-#RNA Expression Profiles of Autoimmune Arthritis Reveal Novel Biomarkers of the Disease and Therapeutic Response

Rheumatoid arthritis (RA) is a chronic autoimmune disease of the joints affecting about 0.3–1% of the population in different countries. About 50–60 percent of RA patients respond to presently used drugs. Moreover, the current biomarkers for RA have inherent limitations. Consequently, there is a need for additional, new biomarkers for monitoring disease activity and responsiveness to therapy of RA patients. We examined the micro-#RNA (#miRNA) profile of immune (lymphoid) cells of arthritic Lewis rats and arthritic rats treated with celastrol, a natural triterpenoid. Experimental and bioinformatics analyses revealed 8 #miRNAs (miR-22, miR-27a, miR-96, miR-142, miR-223, miR-296, miR-298, and miR-451) and their target genes in functional pathways important for RA pathogenesis. Interestingly, 6 of them (miR-22, miR-27a, miR-96, miR-142, miR-223, and miR-296) were further modulated by celastrol treatment. Interestingly, serum levels of miR-142, miR-155, and miR-223 were higher in arthritic versus control rats, whereas miR-212 showed increased expression in celastrol-treated rats compared with arthritic rats or control rats. This is the first study on comprehensive #miRNA expression profiling in the adjuvant-induced arthritis (AA) model and it also has revealed new #miRNA targets for celastrol in arthritis. We suggest that subsets of the above #miRNAs may serve as novel biomarkers of disease activity and therapeutic response in arthritis. http://bit.ly/2M2TzfC #MDPI

[cancersfakianakis1]

Celastrol inhibits colorectal cancer cell proliferation and migration through suppression of MMP3 and MMP7 by the PI3K/AKT signaling pathway

Colorectal cancer (CRC) is one of the most frequent malignant tumors. Signaling by the PI3K/AKT pathway is crucial for CRC development and progression, including proliferation and migration. Celastrol has an anticancer effect, but its mechanism needs to be determined. Here, we showed that celastrol suppressed CRC cell proliferation and migration. Celastrol treatment also decreased the PI3K/AKT pathway components, and MMP3 and MMP7 expression levels. In addition, knockdown of AKT, not mTOR, inhibited MMP3 and MMP7 expression levels and AKT silencing promoted the celastrol-induced effects on CRC cell proliferation and migration. Taken together, these findings indicated that the celastrol-induced antitumor effects were mediated through MMP3 and MMP7 by the PI3K/AKT signaling pathway. https://ift.tt/2IAAkFu

[hardikhh6]

Global Celastrol Market 2019 | Manufacturers In-Depth Analysis Report to 2024

The latest trending report Global Celastrol Market 2019-2024 added by DecisionDatabases.com

Celastrol is a triterpenoid antioxidant compound isolated from the Chinese Thunder of God vine.

Celastrol has a strong antioxidant effect, anti-cancer neovascularization, anti-rheumatoid effect, the role of spermicidal, etc., is currently worthy of attention to the natural active products in the current anti-cancer, Nerve has a prominent effect of the study.

The worldwide market for Celastrol is expected to grow at a CAGR of roughly xx% over the next five years, will reach xx million US$ in 2023, from xx million US$ in 2017.

This report focuses on the Celastrol in global market, especially in North America, Europe and Asia-Pacific, South America, Middle East and Africa. This report categorizes the market based on manufacturers, regions, type and application.

Browse the complete report and table of contents @ https://www.decisiondatabases.com/ip/39595-celastrol-market-analysis-report

Market Segment by Manufacturers, this report covers

·          Creative Dynamics

·          Xa Bc-Biotech

·          Xi’an Lyphar Biotech

·          Shaanxi Undersun Biomedtech

·          Xian Biof Bio-Technology

·          Xi’an Hao-Xuan Bio-Tech

Market Segment by Regions, regional analysis covers

·          North America (United States, Canada and Mexico)

·          Europe (Germany, France, UK, Russia and Italy)

·          Asia-Pacific (China, Japan, Korea, India and Southeast Asia)

·          South America (Brazil, Argentina, Colombia etc.)

·          Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa)

Market Segment by Type, covers

·          0.95

·          0.98

·          Others

Market Segment by Applications, can be divided into

·          Pharma and Healthcare

·          Beverages

·          Others

Download Free Sample Report of Global Celastrol Market @ https://www.decisiondatabases.com/contact/download-sample-39595

There are 15 Chapters to deeply display the Global Celastrol market.

Chapter 1, to describe Celastrol Player product scope, market overview, market opportunities, market driving force and market risks. Chapter 2, to profile the top manufacturers of Celastrol Player, with price, sales, revenue and global market share of Celastrol Player in 2017 and 2018. Chapter 3, the Celastrol Player competitive situation, sales, revenue and global market share of top manufacturers are analyzed emphatically by landscape contrast. Chapter 4, the Celastrol Player breakdown data are shown at the regional level, to show the sales, revenue and growth by regions, from 2014 to 2019. Chapter 5, 6, 7, 8 and 9, to break the sales data at the country level, with sales, revenue and market share for key countries in the world, from 2014 to 2019. Chapter 10 and 11, to segment the sales by type and application, with sales market share and growth rate by type, application, from 2014 to 2019. Chapter 12, Celastrol Player market forecast, by regions, type and application, with sales and revenue, from 2019 to 2024. Chapter 13, 14 and 15, to describe Celastrol Player sales channel, distributors, customers, research findings and conclusion, appendix and data source.

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[stiri-noi]

A fost descoperită planta care ajută la pierderea în greutate - Digi24

[lifebalancenow]

Help Rheumatoid Arthritis with Thunder God Vine

Help Rheumatoid Arthritis with Thunder God Vine

KETO RECIPES CHANNEL:

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DATA:

Could this herbal remedy for rheumatoid arthritis really help?

Timestamps: 0:00 Herbal remedy for rheumatoid arthritis 0:10 What is thunder god vine? 0:45 Side effects of thunder god vine 1:05 Dosage of thunder god vine 1:22 Celastrol

In this…