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ayurvedakidneytreatment · 3 years

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How Rapid Progression of Chronic Kidney Disease CKD?

Chronic kidney disease primarily advances slowly. Blood and urine tests can assist specialists in deciding whether the kidneys are still functioning admirably enough or whether dialysis will be required soon, for instance.

Blood and urine tests are beneficial for something other than diagnosing chronic kidney disease. Standard testing is crucial later on: The tests can show whether the disease is deteriorating and how rapidly. They can likewise help in finding out about the risk of complications. Depending upon the stage of the disease, the treatment can be individually adjusted, and the next treatment steps can be discussed and arranged with the specialist in advance. This is significant if it becomes clear that obviously dialysis will be required.

What are the stages of Chronic kidney disease?

Chronic kidney disease has five stages:

Stage 1: Urine tests give signs of kidney harm. However, healthy parts of the kidneys assist them in working continuously.

Stage 2: As well as the indications of kidney damage, the kidneys aren’t working at their total capacity. However, their capacity is just marginally diminished, and there are usually no observable side effects.

Stage 3: Kidney work is moderately decreased.

(Read here deeply Stage 3 of Chronic Kidney Disease CKD)

Stage 4: Kidney work is essentially reduced. Issues like itching, anaemia, acidosis, or pain in bones might happen.

(Read here deeply Stage 4 of Chronic Kidney Disease CKD)

Stage 5: End-stage kidney disease: The kidneys in this stage are not ready to clean the blood well enough, resulting in severe uremia (poisoning because of the development of byproducts in the body). Dialysis or a kidney transplant are then required to do the kidneys’ work.

The health implications of chronic kidney disease will likewise rely upon how healthy somebody is. Hence, specialists investigate conditions that might worsen Chronic kidney disease quicker — including cardiovascular disease, ineffectively managed hypertension, or diabetes.

Estimation of kidney damage and kidney capacity

Kidney damage and kidney capacity are firmly related. The glomerular filtration rate is the main factor of kidney work. Proof of kidney damage is given by the measure of protein in the individual’s urine.

Glomerular filtration rate

Every kidney has around 1,000,000 small “filtering stations” in it called renal corpuscles. The glomerular filtration rate (GFR) shows how much blood is filtered each minute. In healthy individuals, this is somewhere in the range of 85 and 135 millilitres per minute.

It would be genuinely challenging to measure the GFR straightly. That is why it’s generally estimated — for example, utilizing the level of creatinine in the blood. Creatinine is a breakdown result of the muscles. The most commonly utilized formula for estimating the GFR also incorporates things like age and sex.

Protein in urine

The kidneys usually keep certain substances in the blood from entering the urine. Kidney damage might become recognizable when those substances are found in urine. Examples incorporate blood proteins like albumin. They are possibly found in significant amounts in urine if the kidneys are harmed. The measure of protein in urine is taken as an indication of how bad the harm is.

How much time does CKD require to advance?

The short and unsatisfying response to this question is… it depends. It can be hard to figure out which indicators will be precise across the board because individual studies can only examine a certain number of factors at one time.

Chronic kidney disease progression has been analysed, however, most of the studies have focused on the reasons for kidney function decline and the probability of CKD to progress to end-stage renal disease (ESRD).

The objective of accurately, consistently anticipating the speed of chronic kidney disease progression stays at the front line of CKD research. Discoveries show that the rate is impacted by many factors and can generally differ, especially in the latter stages of the disease.

How rapidly Does Chronic Kidney Disease Progress?

Chronic kidney disease (CKD) doesn’t advance at a similar rate for all patients. A certain number of patients with mild to moderate CKD don’t encounter an anticipated pattern of disease progression.

Components like genetics, health problems, age, sex, and lifestyle also impact the speed of CKD movement.

While this makes a question, “How quick does constant kidney sickness progress?”

What are a few indicators of chronic kidney disease progression?

While the pace of disease progression will be different for everyone, numerous studies have shown that dependable indicators of rapid progression include:

Proteinuria (higher than the normal measures of protein in urine)

Anaemia (less oxygen-carrying red blood cells)

Congestive cardiovascular breakdown (and past cardiovascular disease)

Hypertension (high systolic blood pressure)

Low serum albumin (low levels of the protein called as albumin in the blood)

People below the age of 65, particularly if they are diabetic.

Longer duration of diabetes before diagnosis

Extra factors that different investigations have displayed to show a rapid progression of CKD include:

Acute kidney injury (AKI)

Being a smoker

Treatment with double RAS blockades

Low haemoglobin levels (<13 g/dL)

Always talk to your primary care physician and follow your treatment plan accordingly.

Ask your primary care physician what amount of daily fluid intake is ok for you, and make sure to add all fluids in your liquid intake, not simply water and cutoff liquor and caffeine utilization.

Monitor and manage medical problems that could increase your risk for complications and rapid disease progression, including:

Hypertension

Cardiovascular disease

Deficiency of iron

Diabetes mellitus (type 2 diabetes)

Take your medicines and modify your daily habits as per your primary care physician’s directions.

Limit your utilization of over-the-counter (OTC) drugs, particularly non-steroidal drugs (NSAIDs) like headache medicine, ibuprofen (Advil, Motrin), and naproxen (Aleve).

Make healthy lifestyle changes.

Always take a diet that:

Is low in potassium and phosphorus

is high in organic products, vegetables, and whole grains;

is low in cholesterol, saturated fats, sugar, and additives;

includes suitable, not extreme, protein; and

Stop smoking, and don’t begin in case you are not a smoker.

limits sodium to 2,300 mg/day, to assist control with blood pressure;

Exercise routinely and regularly, somewhere around 30 minutes per day, five days a week.

How Ayurvedic Treatment Cures CKD Kidney Failure?

Ayurveda is thousands of years old and has a unique treatment. Ayurveda helps you to improve your health without using any modern treatment and medicine. Ayurveda treatment is based on natural herbal medicine.

Yes, Ayurveda treatment is the cure for CKD. Through the Ayurveda, you can recover your kidney function 100 percent without any side effects on your health and kidney.

If you are in the last stage of CKD kidney failure or whatever stage you are in, still there is a chance you can remove your CKD chronic kidney disease through Ayurveda treatment. Our experts help you with this.

Conclusion:

Countless elements can add to how rapidly chronic kidney disease progresses. CKD progress is also dependent on genetics, age, sex, and other various health aspects. Ayurveda treatment for chronic kidney disease is helpful for your health and enhances your kidney function through natural medicine.

FAQs

1) What is CKD?

Ans- A condition in which the kidney loses its function over a period of time.

2) Why did I get kidney disease?

Ans-Kidney disease occurs due to malfunctioning of kidneys because of unhealthy lifestyle, unhealthy eating habits.

3) How could I have kidney disease if I feel fine?

Ans- In the initial stage, you can’t recognize the symptoms of CKD and a person may not feel sick.

4) Can kidney disease be cured?

Ans- Yes it can be cured with ayurvedic. Ayurveda is a unique and old treatment that is used for improving your health and providing the opportunity to live healthily.

5) Does kidney disease increase my risk for other health problems?

Ans- Yes, by kidney disease you will suffer lots of health problems like Kidney stones, Glomerulonephritis, Polycystic kidney disease, Urinary tract infections, and much more. You must consult your doctor.

6) What happens if my kidney fails?

Ans- You will be in deep trouble as you will have to suffer from many symptoms.

7) How can I protect my kidneys?

Ans- A healthy lifestyle with a proper diet can keep your kidneys healthy.

8)What other health problems can CKD cause?

Ans- CKD can cause many other issues like Gout, Metabolic acidosis, Secondary hyperparathyroidism, Bone disease and high phosphorus (hyperphosphatemia), Heart disease, High potassium (hyperkalemia), Fluid buildup, cardiovascular disease, which will hamper your health.

Author bio:

Prabhat Kumar has been working in the field of medical sciences for many years. Over the years, I worked with numerous Ayurvedic organizations as a Health Expert. I am enlightening readers with information related to all kinds of diseases and their ayurvedic treatment.

Source of Content: How Rapid Progression of Chronic Kidney Disease CKD?

#How Rapid Progression of Chronic Kidney Disease CKD #How fast Progression of Chronic Kidney Disease CKD #How fast Chronic Kidney Disease CKD Progression #How fast Chronic Kidney Disease CKD #Chronic Kidney Disease CKD #Chronic Kidney Disease

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lindafrancois · 3 years

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Benefits of Plant-Based Eating in Kidney Disease, Part 1

Traditionally, plant-based diets have been considered the wrong choice for some patients with chronic kidney disease (CKD) due to their high potassium content. However, recent studies show plant-based diets may slow the progression of kidney disease and have other benefits for overall health.1 In this first part of a two-part series, we’ll discuss benefits of a plant-based diet in CKD, including its effects on weight, blood pressure, diabetes and inflammation.

Weight

There are lower rates of obesity and overweight among vegetarians in the general population.2 One diet and weight researcher, Mozaffarian, and team found that eating plant-based foods did not contribute to weight gain.3 Studies have also found that eating a vegetarian diet unrestricted in calories for more than four weeks was associated with an average weight loss of 7.5 pounds.4 More research is needed on the effects of plant-based diets on body weight, specifically in people with CKD.

Blood Pressure

Diets like the Dietary Approaches to Stop Hypertension (DASH), which include high intake of fruits and vegetables, are recommended to improve blood pressure in the general population.2 There are limited studies that include CKD patients. One study, by Goraya and others, compared the treatment of metabolic acidosis with sodium bicarbonate tablets to a base-producing fruits and vegetables diet in people with stage 4 CKD.5 In addition to the fruits and vegetables diet improving metabolic acidosis, systolic blood pressure was lower compared to the group treated with sodium bicarbonate at 1 year.

Diabetes

Insulin resistance is a risk factor for cardiovascular disease.2 Insulin resistance is common in all stages of CKD. In a population of people with diabetes, ovo-lacto-vegetarians (vegetarians whose diet includes dairy products, eggs, vegetables, fruits, grains and nuts) showed higher insulin sensitivity compared to the meat eaters and the degree of sensitivity correlated with years following a vegetarian diet.6 A review of several studies on people with diabetes found that a vegetarian diet combined with exercise was associated with a reduction in the use of glucose-lowering medications and hemoglobin A1c.7 There are few studies including CKD patients. A small study found that after three months following a plant-based protein diet, fasting glucose levels were reduced in patients with CKD stages 4-5.8

Inflammation

Uremic toxins are produced during the breakdown of amino acids. Normally, the toxins are removed by the kidneys, but in people with CKD the toxins build up in the blood.9 The toxins contribute to inflammation and oxidative stress and increase risk for cardiovascular disease and insulin resistance. Production of uremic toxins are affected by the diet. A diet high in animal protein produces more uremic toxins. A diet high in plant protein can reduce the levels of uremic toxins. Researcher Wu and team found that in dialysis patients, a vegetarian diet was associated with lower serum blood urea nitrogen, creatinine and C-reactive protein.10

Summary

Plant-based diets have been studied more in the general population and have been found to aid in weight loss, blood pressure control, diabetes control and inflammation. There are some studies that include people with CKD that have found the same benefits as in the general population. So, keep eating those fruits and vegetables! A plant-based diet may help people with CKD maintain a healthy weight, lower blood pressure and glucose levels, and help decrease inflammation.

Look for Part 2 in this series that discusses a condition called metabolic acidosis and how plant-based diets can improve it.

References:

What is a Plant-based Diet, and Is it Good for Your Kidneys? National Kidney Foundation. Accessed March 3, 2021. Reviewed August 18, 2018. https://www.kidney.org/atoz/content/what-plant-based-diet-and-it-good-kidney-disease.

Vegetarian diet and chronic kidney disease. Chauveau et al. Nephrology Dialysis Transplantation. 2019, 34:199-207. https://academic.oup.com/ndt/article/34/2/199/5049714.

Changes in diet and lifestyle and long-term weight gain in women and men. Mozaffarian et al. New England Journal of Medicine. 2011, 364:2392-2404.

A systemic review and meta-analysis of changes in body weight in clinical trials of vegetarian diets. Barnard et al. Journal of the Academy of Nutrition and Dietetics. 2015, 115:954-969.

A Comparison of Treating Metabolic Acidosis in CKD Stage 4 Hypertensive Kidney Disease with Fruits and Vegetables or Sodium Bicarbonate. Goraya et al. Clinical Journal of the American Society of Nephrology. 2017, 8(3):371-381. https://cjasn.asnjournals.org/content/clinjasn/8/3/371.full.pdf?with-ds=yes.

Insulin sensitivity in Chinese ovo-lactovegetarians compared with omnivores. Kuo et al. European Journal of Clinical Nutrition. 2004, 58, 312-316.

Vegetarian diets and glycemic control in diabetes: A systemic review and meta-analysis. Yokoyama et al. Cardiovascular, Diagnosis, and Therapy. 2014, 4, 373-382.

Low protein diet in uremia: effects on glucose metabolism and energy production rate. Rigalleau et al. Kidney International. 1997, 51:1222-1227.

Vegetable-based diets for chronic kidney disease? It is time to reconsider. Cases et al. Nutrients. 2019, 11, 1263. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627351/pdf/nutrients-11-01263.pdf.

Nutritional status of vegetarians on maintenance hemodialysis. Wu et al. Nephrology (Carlton). 2011, 16, 582-587.

Additional Kidney Diet Resources

Visit DaVita.com and explore these diet and nutrition resources:

DaVita Food Analyzer

DaVita Dining Out Guides

Today’s Kidney Diet Cookbooks

DaVita Kidney-Friendly Recipes

Diet and Nutrition Articles

Diet and Nutrition Videos

Kidney Smart® Virtual Classes

This article is for informational purposes only and is not a substitute for medical advice or treatment. Consult your physician and dietitian regarding your specific diagnosis, treatment, diet and health questions.

Benefits of Plant-Based Eating in Kidney Disease, Part 1 published first on https://dietariouspage.tumblr.com/

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falgunikurian · 4 years

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How To Prevent Kidney Failure? Chronic Kidney Disease

Chronic Kidney Disease, transplants, and Prevent Kidney Failure have become quite common in recent times. Log in to a list of top trustworthy Clinical blogs for disease information or visit a top doctor for tests and dealing with the failure of kidney, disease, and transplant.

This can be associated with the fast-paced, pressured, and stressful life that everyone adheres to. The food and fluid that we consume today have a lot of additives which causes significant problems in urine and top or high damage to the kidney which needs a transplant.

With diseases like COVID-19, we need to better monitor our kidney health. Numerous trials are in progress, though common, management, and prevention of kidney disease and failure are achievable. Education and resources around kidney health and kidney-friendly habits are pretty limited.

Following is an overview where you can learn the symptoms of Chronic kidney failure and ways to prevent it. You don’t have to give or fund expensive treatments or tests or break into your savings fund resources to keep your kidneys healthy without dialysis. Join a good health plan at the Best Kidney Hospital and get kidney-friendly recipes if needed.

Symptoms of Kidney Failure

There are a few top symptoms from a list that can point towards a failing kidney or complications. Following are some of the clinical chronic signs to look for: It’s important to learn to identify and manage Chronic symptoms or disease complications on your own and join dialysis if needed to prevent a transplant from the Best Kidney Doctor.

High itching

High trouble sleeping

Muscle cramps

Nausea/Vomiting

Loss of Appetite

Blood in urine

Feet and Ankle Swelling

Irregular flow of Urine

Trouble Catching Breath

Another sudden disease

While the top chronic Clinical symptoms and disease problems are high signs of a failing kidney or kidney damage/complications, they defer from signs of the sudden shutdown of all functionality. The following are the symptoms of acute or Chronic kidney failure or damage which may require transplants or dialysis.

Join a good health plan and eat different types of kidney-friendly recipes if needed. Don’t give in to pressure and eat healthy to prevent a transplant.

High Abdominal Pain

High Fever

Vomiting

Rash

High Back Pain

Diarrhea

High Nosebleeds

Anemia

Any of the above-mentioned top symptoms and types of Chronic problems or complications in urine can occur in a cluster or individually and lead to kidney failure. Numerous types of trials are in progress to manage these conditions.

If any of these symptoms occur in a severe fashion then a doctor must be consulted for tests or dialysis. Login to trustworthy blogs for more information on transplants and dialysis. However, it’s important to learn to identify and manage high symptoms on your own as education around kidney health and kidney-friendly habits is limited.

Join a good health plan and eat a list of kidney-friendly recipes if needed. Don’t give in to temptation and eat healthy for the sake of your health and prevent a transplant in the Best Kidney Hospital.

Causes of Chronic Kidney Disease (CKD)

There are a few top reasons that people can develop CKD. It may require transplants or Clinical dialysis. Numerous lists of Clinical trials are in progress to find better treatments for this. It’s important to learn to identify and manage Clinical symptoms on your own with proper education or visit Best Kidney doctor in Coimbatore for assistance. These types of list of reasons include:

Family history or a list of Kidney failure needing a transplant.

Impaired Blood flow: Pressure complications that interrupt blood flow to the kidneys causes kidney failure problems. Heart attack, heart disease, infection, anemia, and liver failure are some of the types.

Blood pressure: If your blood pressure is abnormally high or low.

Kidney Damage: There is a list of complications that cause enough kidney problems that lead to failure. Blood clotting in and around the kidney, cholesterol deposits, glomerulonephritis, lupus, and infection due to diseases like COVID-19 are some types of diseases to look out for and test for.

Urine Blockage: complications that block the free flow of urine are a common reason for kidney problems. Bladder cancer, blood clots in the urinary tract, cervical cancer, and kidney stones are some of the examples. Don’t give in to fear and seek treatment for the sake of your health and prevent transplant.

Prevent Kidney Failure

Kidney Failure is a serious condition and if goes untreated by a Clinical doctor will lead to complications like high blood pressure, which may lead to fluid dialysis and you eventually get a transplant or multiple transplants.

However, Prevent Kidney Failure are a few simple steps recommended by the best kidney specialists and American specialists which can help you prevent developing CKD and complications. Numerous trials are in progress to find better treatments for CKD.

Problems in urine like CKD is usually the first sign. Login to trustworthy blogs for more information on dealing with this. Education around kidney health, CKD, and kidney-friendly habits are quite limited. Join a good health plan and eat kidney-friendly recipes if needed to manage CKD.

Don’t hesitate to ask for Clinical assistance at the Best Kidney Hospital in Coimbatore. Remember to keep your blood pressure in check. Don’t give in to temptation and eat healthy for the sake of your health.

Healthy Food to Prevent Kidney Failure

This is a simple step and has many advantages to other parts of your body too. Look for types of diet or recipes of fresh fruits and vegetables, whole grains, low-fat or fat-free dairy products to keep your heart healthy. To have working kidneys and avoid kidney failure, one thing to watch out for is your salt intake.

It is advised to stop or reduce your sodium intake in recipes, less than 2,300 mg/day to be specific. Best Kidney Doctor suggests Other kidney-friendly food tips follow are broiling protein (meat and fish) rather than frying, use skim milk, choose food less in saturated & trans fats, reduce snacking, keeping a diet record, etc. Drink plenty of fluid.

Login to trustworthy blogs for more recommended diets and tests. It’s important to learn to identify and manage symptoms on your own as education around kidney health and kidney-friendly habits is very limited. Join a good health plan and eat kidney-friendly recipes if needed.

Don’t hesitate to ask for Clinical assistance and remember to keep your blood pressure in check. Don’t give in to temptation and eat healthy for the sake of your health and prevent transplant.

Maintain a Healthy Weight

A lot of types of diseases like heart disease, CKD, unhealthy types of recipes, and diabetes are related to obesity and anemia, according to American doctors. Most of these types of diseases lead to the development of heart and kidney failure needing a transplant.

To get working kidneys and avoid kidney failure one must maintain a kidney-friendly weight. Management of healthy weight requires planning and discipline. Some of the best kidney doctors recommend taking the assistance of NIH Body Weight Planner. It is an online tool that helps plan out your physical activity to lose calories and maintain a healthy weight.

You can also work with a dietitian to test and create and join an actionable weight-loss plan and get Clinical assistance for CKD. Remember to keep your blood pressure in check. Don’t give in and stay active for the sake of your health.

Get Enough Sleep to Prevent Kidney Failure

A lot of problems regarding health like CKD can be directly related to poor sleep. Your body needs to rest and relax to restore its strength and run at maximum capacity. Doctors believe 6-8 hours of sleep per night is kidney-friendly for working adult life. Other than getting enough sleep, it should be uninterrupted. Numerous trials are in progress to find better treatments.

Make sure to have a comfortable mattress and not to consume any substance like sugary drinks and coffee before sleep. Get the right kidney education for CKD and get Clinical assistance. Remember to keep your blood pressure in check. Don’t give in and consult CKD specialists for the sake of your health.

Regular Exercise

To have working kidneys and avoid kidney failure, you need to give regular exercise to keep your mind and body in shape and improve your life. Get an education on what’s right for your body. A vigorous activity like exercising is very kidney-friendly and helps increase vascular diameter, which improves blood flow to all parts of the body, including the kidney.

This helps them remain healthy. Research shows the increase in blood flow also helps clean your vascular pipes from accumulated cholesterol which causes CKD and kidney failure. You can either workout at home or join a gym. Remember to keep your blood pressure in check.

Quit Smoking/Drinking

The kidney’s function is to clean the blood of all the impurities and remove it in the form of urine. While simple impurities that come with food and water don’t damage the kidneys, complex substances within tobacco and alcohol are different. Excluding them from the body can give significant damage to the kidneys and stops them from working like CKD.

While smoking is not very kidney-friendly and must stop completely for a better life, there is some concession in drinking alcohol. To get working kidneys and avoid kidney failure research shows that a man must limit themselves to 2 drinks per day.

One drink equals 12 ounces of beer, 5 ounces of wine, and 1.5 ounces of hard liquor like whiskey. Remember to keep your blood pressure in check too. Don’t give in and stay healthy for the sake of your kidneys.

Reduce Stress Inducing Activities

Best Kidney Specialist says that Mental stress can create an imbalance in your body and causes many troubles like heart disease and ulcers. All of your organs are on high alert and work on overdrive due to increased blood flow. This damages your organs like the kidneys and can lead to chronic kidney disease in the future.

To have working kidneys and avoid kidney failure, there are a few resources and activities that you can follow like meditation, yoga, and tai chi which helps reduce your stress and pressure-related problems. They give you peace of mind.

Lots of Water

Your kidneys use water as a medium to remove any waste from the blood. To have working kidneys and avoid kidney failure and CKD, it is always advised to drink lots of water because it maintains a healthy concentration of water to waste in the kidneys and keep them working.

Read Also: Ayurvedic Treatment For Kidney Failure

If water is less, then the urine pH levels are too high and cause significant damage due to pressure. Research and resources show that 8 glasses or 4 liters of water per day helps in the management of healthy pH levels. Problems in urine are usually the first sign of kidney trouble.

Limit Pain Medication

If you are on any medication for a pre-existing condition make sure that it is taken as prescribed. Taking medication without prior consultation causes major complications. This can lead to your kidney’s health getting affected.

Also, you must limit the usage of over-the-counter resources and pain medication like ibuprofen. Nonsteroidal anti-inflammatory drugs are not kidney-friendly and have been known to cause problems for the kidneys due to pressure. Don’t hesitate to ask for assistance.

#Kidney Failure Symptoms To Kidney Failure Chronic Kidney Disease Chronic Kidney Disease (CKD) Symptoms

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pharmaphorumuk · 4 years

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AZ trumpets Farxiga survival data in renal disease at ESC 2020

AstraZeneca’s Farxiga is already ahead of rivals in the SGLT2 inhibitor field in heart failure, and now looks set to repeat that success in renal disease after reporting stellar results from the DAPA-CKD trial.

AZ halted DAPA-CKD in July after revealing that Farxiga (dapagliflozin) met its objective of slowed the worsening of renal function and cut the risk of death in patients with chronic kidney disease (CKD) with and without type 2 diabetes.

Now, detailed findings presented at the European Society of Cardiology (ESC) meeting over the weekend showed just how well the drug performed, and have the potential to “transform the standard of care” in patients with CKD, according to the trial investigators.

Adding Farxiga to standard therapy resulted in a 39% reduction in the composite measure of worsening renal function or death due to cardiovascular or kidney disease compared to placebo, DAPA-CKD’s primary endpoint. It also hit all secondary objectives, notably achieving a 31% cut in the chance of dying from any cause.

CKD is a progressive condition that affects almost 700 million people around the world, but has limited treatment options other than old drugs like ACE inhibitors and angiotensin 2 receptor antagonists. That unmet need prompted the FDA to award Farxiga fast-track status in CKD last year.

There were already signs from cardiovascular outcome studies that SGLT2 inhibitors like Farxiga and Boehringer Ingelheim/Eli Lilly’s Jardiance (empagliflozin) could preserve renal function in type 2 diabetics.

However, DAPA-CKD is the first large-scale trial to test an SGLT2 specifically in both diabetic and non-diabetic patients with CKD, and showing a clear and sizeable impact on survival goes beyond expectations.

Mene Pangalos, executive vice president of biopharmaceuticals R&D at AZ, who described the data as showing “overwhelming efficacy” when the top-line result was released in July, said that AZ would now be sharing the DAPA-CKD results with regulators around the world.

Farxiga is at the forefront of widening the use of SGLT2 inhibitors beyond their traditional role as treatments for type 2 diabetes.

The company already picked up approvals for Farxiga to reduce the risk of hospitalisation in heart failure patients with type 2 diabetes, and as a standalone treatment for heart failure with reduced ejection fraction (HFrEF) in patients with and without diabetes.

At ESC 2020 Boehringer and Lilly showed off positive results with Jardiance in in the EMPEROR-REDUCED trial in HFrEF that could allow it to challenge Farxiga’s first in class approval for that indication, with filings possible within the next few months. It also suggests that the impact of SGLT2 drugs in heart failure could be a class effect.

In the meantime, Farxiga looks on course to secure the first approval for an SGLT2 inhibitor in CKD as well, although Boehringer and Lilly are in hot pursuit, claiming a fast-track designation from the FDA for Jardiance in that indication in March.

The two partners are carrying out the EMPA-KIDNEY trial in CKD patients with and without diabetes, with results due in 2022 – unless like DAPA-CKD the trial is halted early.

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heartcareinstitute · 5 years

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How Obesity impacts Chronic Kidney Disease (CKD)

Many factors contribute to obesity. It could be due to unhealthy eating habits, sedentary lifestyle, lack of exercise and various psychological factors like depression, stress, genetic or family history, etc.

No matter what’s your reason for being obese, the problem with this condition is that it increases the risk of many diseases, including chronic kidney disease.

How Obesity Impacts Chronic Kidney Disease (CKD):

The best kidney specialist in Delhi says that obesity can increase the load on kidneys and leads to increased glomerular permeability and hyperfiltration. Due to the rise in renal plasma flow, a person is likely to suffer from proteinuria and hypertension. Podocyte dysfunction, renal hemodynamic abnormality, and endothelial dysfunction may also occur due to higher levels of angiotensin II and hyperinsulinemia.

Obese patients with renal biopsy may have focal segmental sclerosis and glomerulomegaly due to no hemodynamic and hemodynamic effects. Hence, Chronic Kidney Disease (CKD) can progress 7X faster in obese patents than a person with normal body weight.

How obesity causes CKD?

Obesity indirectly causes CKD, as an obese person can easily suffer from hypertension and diabetes that are responsible for causing CKD more than 70% times in people with obesity.

Besides CKD, an obese person is likely to suffer from obstructive sleep apnoea, heart disease, gall stones, NASH and body cancer.

How to manage obesity

According to a kidney specialist in Delhi, you can control obesity only by making some lifestyle modifications, such as dietary restrictions, increased physical activity and behavioral therapy.

Here are the five important things you need to follow to manage your weight:

1. You must do regular aerobic exercises for at least 30 minutes every day. Regular exercising like running, brisk walking, dancing, HIIT worktop, etc. can help in controlling your weight, making you feel energetic all the time.

2. Make sure that your diet includes low dense calories, high potassium, low sodium, and low trans-fats. Try to have more fresh vegetables, fruits, and healthy foods. Moreover, try to avoid alcohol, frozen food, and fast food as much as you can.

3. Pharmacotherapy: It includes the use of a handful of drugs that are mostly anorexiants that help in inhibiting fat absorption and causing steatorrhea. These drugs must be taken under the supervision of a physician, as most of them are potentially toxic.

4. Behavioral therapy includes counseling for relieving depression and stress for eating habits. Making certain behavior changes, such as don’t eat fast food every time you feel hungry, keeping a strict diet and not eating too much, are important to maintaining a healthy weight.

5. Bariatric surgery is suggested to people whose BMI is more than 40 kg/meter square or people who are obese with a BMI of 35-40 kg/meter, along with certain obesity-related complications. The procedure is called gastric bypass surgery. It helps in reducing the overall mortality of a person by 40%. This surgery is performed laparoscopically to reduce the patient’s stomach capacity to 200-cc or simply through Roux en Y gastric bypass surgery.

Simple tips to prevent kidney disease

- Drink 3 to 4 liters of water every day

- Be fit and active

- Control body weight by eating healthy

- Avoid smoking, drugs or alcohol

- Get regular screening done for better kidney function.

#kidney specialist in india #kidney #specialist

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sherristockman · 8 years

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Veggies Work Better Than Drugs for Kidneys Dr. Mercola By Dr. Mercola Say you're told you have kidney disease. Knowing these vital organs remove waste and toxins from your system, stimulate the production of red blood cells and regulate your blood pressure, you know you need to do something fast. It's very likely that one of the first things your doctor will do is put you on a regimen of medications. But a new, five-year study just emerged revealing that one of the best things you can do for your kidneys is to eat three or four servings of vegetables and fruits daily. Not only can they help you regain your health but also may help save you money on medical costs, including medication. In fact, eating healthy fruits and vegetables could help cut your drug costs by as much as 50 percent. Eating the Right Foods Improves Your Kidney Function You might be wondering how that works. According to the study at the University of Texas, it starts with a shift in nutrition. Certain foods help you manage your blood pressure better than others and, at the same time, improve several other aspects of your health, potentially initiating healthier readings in things like systolic blood pressure. The five-year study showed that a positive change in diet lowered the systolic blood pressure of subjects with kidney disease better than those who opted for medication. U.S. News reported that the study tracked a small number of participants with kidney concerns so researchers could compare standard medical treatment outcomes with nutritional intervention. The goal of the scientists was to determine who did better — the people in the drug group or those in the food group. The two gauges were not only which did better at naturally decreasing blood pressure but also whether or not using food to do it could make any difference in costs. You already know the outcome. Healthy food prevailed, hands down. Study participants showed improvement the first year, and drug costs lowered every year thereafter, saving an average total of $153,000 for the veggie group over the span of the five-year study.1 Dr. Nimrit Goraya, study author and program director for nephrology at Baylor Scott & White Healthcare in Temple, Texas, said that for people with kidney disease — or those wanting to prevent it — the importance of eating the right foods rather than settling for medications was "huge." Other studies show that taking blood pressure drugs may increase your risk of death. Vegetables and Exercise — Stunning Findings for Blood Pressure A 28-study review at the University of Sao Paulo, Brazil, involving more than 1,000 patients on kidney dialysis, resulted in more very promising statistics. Scientists found that those who regularly employed both aerobic and resistance (strength) training exercises lowered their blood pressure readings significantly.2 Lona Sandon, clinical nutrition program director at the School of Health Professions at UT Southwestern in Dallas, noted that three or four servings of veggies and fruits, depending on the type, make all the difference: "It is remarkable what fruits and vegetables can do, along with a little exercise. Blood pressure meds come with many side effects that may leave people feeling sluggish, or other problems. The side effects of fruits and vegetables and exercise is better health. When people have access to healthy foods, they can change their health. And especially when they eat the recommended amounts that were provided to them in the study."3 High Blood Pressure: the Second-Highest Cause of Kidney Failure A few years ago, the U.S. Centers for Disease Control and Prevention (CDC) announced that high blood pressure fatalities were on the rise. Many people don't realize that the kidneys and circulatory systems work together to prevent high blood pressure (HBP), aka hypertension. As the American Heart Association4 reveals, kidney damage from high blood pressure occurs three ways: First, HBP causes artery damage. The dense blood vessels and arteries in kidneys mean that high amounts of blood flow through them, but because this disease weakens them, adequate blood can't be delivered to kidney tissue. Blood doesn't filter properly through damaged kidneys. Miniscule, finger-like nephrons filtering your blood get their supply through even smaller, hair-like capillaries, but with kidney damage, they don't get the oxygen or nutrients they require. Hormones, acids, salts and other fluids in your body are left unregulated. Blood pressure is also unregulated and doesn't produce an important hormone for it to self-regulate, beginning a downward spiral. More arteries become blocked and stop functioning, causing kidney failure. This all sounds pretty grim, but the important thing to remember is that this usually happens gradually over several years — and it can be prevented. In the U.S. every third person aged 65 and older has chronic kidney disease, or CKD. Most don't progress toward advanced stages because they succumb to end-stage renal disease first, even if they have stage 4 CKD, a 2014 study in the journal Clinical Practice reveals.5 An Italian study found that consuming just 7 grams a day of protein led to a reduction in kidney failure. Perhaps more importantly, an argument was made that a low-protein diet is far preferable to one containing excessive protein.6 That said, you may need to restrict your protein intake. About one-half gram of protein per pound of lean body mass is all you need. Fructose should only be eaten in small amounts — about 25 grams or 6 teaspoons — per day (in spite of the fact that the American Kidney Fund allows for as much as 40 to 50 grams). DaVita, a kidney education website, notes: "Researchers are discovering more and more links between chronic diseases inflammation and "super foods" that may prevent or protect against undesirable fatty acid oxidation, a condition that occurs when the oxygen in your body reacts with fats in your blood and your cells. Oxidation is a normal process for energy production and many chemical reactions in the body, but excessive oxidation of fats and cholesterol creates molecules known as free radicals that can damage your proteins, cell membranes and genes."7 Besides kidney disease, some of the diseases studies have associated with free radical damage include cancer, Alzheimer's disease, heart disease and other recurring and degenerative conditions. But foods containing antioxidants can help neutralize and protect your body from free radical damage. Foods containing phosphorous tend to promote kidney stone formation. Foods with high amounts of potassium, such as vegetables and seeds, are good choices, in moderation. Unfortunately, only 2 percent of people in the U.S. get adequate amounts of potassium, often because the others eat too many processed foods. The top 15 fruits, veggies and other foods8,9 containing potent antioxidants for a healthy balance between sodium, potassium and phosphorus include: ✓ Red bell peppers ✓ Cabbage, cauliflower and kale ✓ Asparagus, string beans and celery ✓ Garlic and onions ✓ Mushrooms ✓ Apples, pears peaches and cherries ✓ Watermelon ✓ Blueberries, strawberries, raspberries and cranberries ✓ Sweet potatoes ✓ Greentea ✓ Nuts and seeds ✓ Red and purple grapes ✓ Eggs ✓ Wild-caught Alaskan sockeye salmon ✓ Olive and coconut oils Be cautious about consuming the fruits on this list, as they can easily push you over the recommended amount of daily fructose. With the clean, healthy foods that help your body maintain and heal itself are foods that you should avoid, especially if you have kidney issues. If you drink soda or any beverage containing high fructose corn syrup or aspartame, stop! Those are chemically-contrived substances that can wreck even the best health. Pure water is the best beverage to put into your body, and if you haven't made this change already, you'll be surprised how much healthier you look and feel. Daily Superfood Love says: "Following a healthy lifestyle and eating the right foods for kidney health will keep your kidneys in shape for decades. Food has been proven repeatedly to turn the tide in many health scenarios – slowing and even stopping further damage to vital organs. A diet filled with powerful superfoods mop up free radicals caused by oxidation and lower inflammation. Study after study for every major disease shows that what you eat matters to how you look, how you feel, and how healthy you are on the inside."10 One way to monitor how you're doing is to check the color of your urine, which should be pale yellow. If it's darker than that, increase your water intake. What Causes Kidney Malfunction? More than 26 million people in the U.S. have chronic kidney disease. According to One Green Planet, kidney disease contributes to other diseases and health concerns: "Kidney disease is strongly linked to other major health issues such as diabetes, hypertension (high blood pressure) and heart disease. Many people who suffer obesity, autoimmune disease or urinary tract infections (UTI's) may also develop kidney disease within their lifetime. Anytime an overall strain is put on the body, the kidneys also take a major hit. Common signs of kidney problems include frequent urination, problems urinating, pain, burning, or constant thirst."11 There are two types of renal malfunction: one is acute kidney injury; the other is chronic kidney disease. • Acute kidney injury (AKI) occurs when there's a sudden reduction in blood flow, resulting in renal failure. In fact, the two terms are synonymous. Severe dehydration, an accident, surgery and even cumulative overdose (or purposeful) of such drugs as acetaminophen, ibuprofen, or naproxen could bring it on. Chronic inflammation, such as what takes place with diabetics or heart disease patients, infections (such as sepsis), blockages or allergic reactions could also cause renal failure. About half of AKI sufferers can be treated without permanent damage; the rest will likely require either a kidney transplant or dialysis, meaning that a machine filters your blood. Symptoms might include pain, weakness, lightheadedness, loss of appetite, nausea and vomiting, extreme thirst, and decreased urination. Interestingly, most acute kidney failure cases occur when people who are already being hospitalized for something else. • Chronic kidney disease (CKD) occurs over time, usually exacerbated by high blood pressure and diabetes. People who have been on lots of medications for an extended period of time are likely candidates, as are those abusing drugs or alcohol. A blocked renal artery may also irreparably damage your kidneys. Age, genetic abnormalities and illnesses such as cancer may influence this condition. Chronic cases may involve the symptoms for AKI to the point of nonfunction. High levels of phosphates in the blood and low levels of iron may occur at this stage. Most health practitioners advise that you eat plenty of vegetables, avoid sugar, drink adequate amounts of water and get crucial, regular exercise, which will not only be good for your kidneys, but may make a profound improvement in your health overall.

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renliname · 8 years

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How Fast does Kidney Disease Progress from Stage 4 CKD to ESRD

Chronic Kidney Disease is a progressive condition where the kidneys do not function properly to keep people healthy. There are 5 stages of CKD. In stage 4, patients only have 15%-29% of kidney function left. If the disease gets worse or is left untreated, end-stage renal disease (ESRD) will occur. Then, how fast does kidney disease progress from Stage 4 CKD to ESRD? Chat with our online doctor for personalized advice!

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lindafrancois · 3 years

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Benefits of Plant-Based Eating in Kidney Disease, Part 1