#Pediatric Neurology

[gauricmi]

Global Leigh Syndrome Treatment market is Estimated to Witness High Growth Owing to Increasing Disease Awareness

The global Leigh syndrome treatment market is expected to exhibit significant growth due to rising prevalence of the rare genetic disorder. Leigh syndrome is a rare and aggressive neurological disorder caused by mutations in mitochondrial DNA or nuclear genes involved in mitochondrial biogenesis and respiration. The characteristic symptoms of Leigh syndrome include developmental delay, loss of motor skills, weakness, vision problems, and respiratory issues. Currently, there is no definitive treatment for Leigh syndrome. Treatments mainly focus on managing symptoms by targeting the underlying cause. Therapies primarily include vitamin and nutritional supplements, physical and occupational therapy, and medications targeting respiratory and neurological complications.

The global Leigh syndrome treatment market is estimated to be valued at US$ 272.9 million  in 2024 and is expected to exhibit a CAGR of 6.7% over the forecast period from 2024 to 2031. Key Takeaways Key players operating in the Global Leigh Syndrome Treatment Market Growth are Abliva AB, PTC Therapeutics, VAKS Pharma, MITOCH, Medley Pharmaceuticals Ltd., Khondrion BV, OMEICOS THERAPEUTICS GMBH. , Edison Pharmaceuticals, Inc. , Dainippon Sumitomo Pharma Co. Ltd., Taysha GTx, PicnicHealth (AllStripes), Takeda Pharmaceutical Company , Biogen, Ionis Pharmaceuticals, Inc., Sarepta Therapeutics, Inc., and MECOSON LABS PRIVATE LIMITED. The global Leigh syndrome treatment market is expected to witness lucrative growth opportunities due to increasing research funding for rare disease drug development and growing orphan drug designations. Furthermore, advancements in understanding the genetics and underlying mechanisms of Leigh syndrome are likely to aid the development of novel targeted treatment options. Key players are actively focusing on expanding their geographical presence through collaborations and partnerships with regional healthcare providers to cater to the growing patient population worldwide. For instance, in 2021, Khondrion partnered with Taysha Gene Therapies to accelerate the clinical development of KH-176, a gene therapy drug candidate for Leigh syndrome. Market Drivers The primary driver propelling the global Leigh syndrome treatment market growth is increasing disease awareness driven by advocacy programs by patient support groups such as United Leukodystrophy Foundation and Cure Sanfilippo Foundation. Growing government efforts to provide orphan drug incentives and streamline the approval process for rare disease drug candidates are also expected to encourage pharmaceutical companies to invest in Leigh syndrome drug R&D.

Get More Insights On This Topic: Leigh Syndrome Treatment Market

[healthcaretechnologynews]

Acute Flaccid Myelitis Market by Treatment Type (Pharmacological Treatment, Physical & Occupational Therapy, Plasmapheresis, and Others) - Global Outlook & Forecast 2023-2031

According to the deep-dive market assessment study by Growth Plus Reports, global acute flaccid myelitis market is expected to register a revenue CAGR of 3.2% during the forecast period.

Acute Flaccid Myelitis Market Fundamentals 

Acute flaccid myelitis (AFM) is a life-threatening illness that appears like polio and was first identified in unusual clusters in California in 2012 and Colorado in 2014. With hundreds of cases recorded in Europe, Asia, Australia, Africa, North America, and South America, AFM is now recognized as a widespread condition. Recent AFM is thought to have been mostly caused by epidemic enteroviral infection, notably enterovirus D68 infection. Cases typically occur in geographic clusters in temperate climates and follow a clear seasonal-biennial pattern. Young children are most often affected by AFM, characterized by an abrupt onset of flaccid weakness in one or more limbs and abnormalities in the grey matter of the spinal cord. Additional muscles may be affected include the extraocular, respiratory, bulbar, and trunk muscles. Clinical signs of other acute weakness-causing conditions, such as Guillain-Barre syndrome, demyelinating myelitis, and other infectious myelitis, may resemble those of AFM.

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Less than 15% of incidents of AFM in adults (more frequently in the immunocompromised) occur, with AFM in adults perhaps needing to be more reported or recognized. AFM is mostly a pediatric condition. There may be a small preference for men. Most AFM patients experience a prodromal sickness that includes a fever and respiratory symptoms (such as a cough, rhinorrhea, pharyngitis, or a disease that resembles asthma). Vomiting and diarrhea are less common gastrointestinal complaints.

Headache, stiffness in the neck, or a return of fever can occur together with the development of neurological symptoms. Pain in the afflicted limb(s), neck, or lower back often precedes limb weakening in patients. Flaccid weakness usually affects one or more limbs and is asymmetrical, with a preference for the upper limbs and proximal muscle groups. In addition to limb weakness, over 30% of patients exhibit motor deficits localized to the brainstem's cranial nerve motor nuclei. These deficits are largely bulbar and facial weakness, with extraocular muscle weakness occurring less frequently.

The most effective diagnostic procedure for AFM is an MRI of the spinal cord. The distinctive feature of AFM is spinal cord grey matter T2 hyperintensity. When examined axially, early acute phase lesions impact the whole grey matter of the spinal cord. They are often confluent and poorly delineated, with varied degrees of surrounding white matter involvement and edema. Grey matter lesions in the spinal cord are often longitudinally widespread.

Acute Flaccid Myelitis Market Dynamics 

The acute flaccid myelitis market is growing due to rising awareness, increasing surveillance initiatives, identification and reporting of AFM cases. The number of reported cases of AFM has increased as medical professionals and public health organizations have become more cautious in finding and diagnosing the condition. For instance, Acute Flaccid Myelitis Association aims to increase public understanding and support for this disease.  They also offer assistance to parents, caregivers, and those who are experiencing AFM symptoms. Their funding is used to meet the requirements of the patients. They utilize donations to pay for therapies, treatments, and equipment not covered by insurance for families. More than 90% of donations are used immediately to meet the critical medical requirements of AFMA grant candidates. Additionally, the federal government has noticed the illness due to the advocacy efforts of AFM-affected families, the Acute Flaccid Myelitis Association (AFMA), and medical professionals who treat patients with the condition. Senator Kirsten Gillibrand, for example, proposed $1 billion in funding for AFM research in 2018.

Accurate and rapid diagnosis of AFM patients has been made possible by improved methods for diagnosis, including laboratory testing and enhanced imaging equipment. This is likely because more information is available on illness and its prevalence. For instance, according to the National Library of Medicine 2021, 96% of documented AFM cases in the USA 2018 were hospital admissions, with 58% going to an intensive care unit. Early management's cornerstone is supportive care and vigilant monitoring targeted toward possibly developing critical problems. Moreover, according to the Centers for Disease Control & Prevention, as of June 2, 2023, twenty reports of patients under investigation (PUIs) had been made, and three of those reports had been confirmed. Since August 2014, when CDC started monitoring AFM, there have been 727 confirmed cases. Since then, the CDC has conducted extensive investigations into cases. In 2014, 2016, and 2018, there was a rise in AFM incidence, particularly involving young children.

However, AFM does not currently have a particular therapy other than symptomatic assistance. Research is still being done to understand the illness better and provide therapies. There are scientific possibilities and needs for further study in AFM, according to a 2020 article in Clinical Infectious Diseases. The long-term outcomes of AFM and juvenile transverse myelitis were compared in a 2020 study published in BMC Neurology.

Acute Flaccid Myelitis Market Ecosystem 

The global acute flaccid myelitis market is analyzed from the following perspectives by treatment type and region.

Acute Flaccid Myelitis by Treatment Type

Based on the treatment type, the global acute flaccid myelitis market is segmented into pharmacological treatment, physical & occupational therapy, plasmapheresis, and others.

There haven't been any regulated investigations of medical AFM therapies.  To increase the body's resistance to viruses, intravenous immunoglobulin (IVIG) can be administered. Steroids and plasma exchange are two common medications used to treat transverse myelitis (TM), and they have been tested in AFM with varying degrees of success. 

Early commencement of physical and occupational therapy (PT and OT) is essential for successfully treating AFM. Both occupational and physical therapy are crucial. Children frequently attend treatment sessions for weeks or months. For the greatest results, children with AFM need to be treated by a multidisciplinary team. Even if full muscle function cannot be recovered, early intervention may improve everyday functioning and restore function to the damaged limbs.

Acute Flaccid Myelitis by Region

Based on the treatment type, the global acute flaccid myelitis market is segmented into North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa. 

The number of instances of poliomyelitis dropped to 209 worldwide in 2014 due to poliovirus vaccinations, with nonpolio enteroviruses being the main cause of new cases of acute flaccid myelitis. Acute flaccid myelitis cases have been observed most recently during enterovirus D68 outbreaks in North America and Europe, indicating the possibility of another non-polio enterovirus linked to acute flaccid myelitis. North America had an outbreak of enterovirus D68 infections in the autumn of 2014, the majority of which were accompanied by symptoms of the upper respiratory tract. The authors describe a cluster of three individuals who had acute flaccid myelitis in Alberta, Canada, during an enterovirus D68 epidemic, with enterovirus D68 found in two of these patients.

The number of reports of acute flaccid paralysis cases has increased in the United Kingdom (UK), with many cases being identified as AFM. Unexpected clusters of AFM were first recorded in the US in 2014. Clinically, various individuals often have poliomyelitis-like paralysis, affecting one or more limbs, with no discernible sensory loss and distinctive grey matter abnormalities on MRI. A prevalent EV virus known as EV-D68, which appeared to circulate biennially in late summer and fall and was connected to severe acute respiratory and neurological disease between 2014 and 2016 in Europe, Asia, and North America, was temporally associated with an increase in AFM cases.

Acute Flaccid Myelitis Market Competitive Landscape 

Some of the prominent market players in the global acute flaccid myelitis market include, 

Baxter International Inc.

Octapharma AG

Behring GmbH

BioScrip Inc.

Pfizer Inc.

Novartis AG

AstraZeneca

GSK Plc.

Cipla Inc.

Acute Flaccid Myelitis Strategic Development 

In August 2019, to comprehend the uncommon polio-like virus that affects children, the National Institute of Allergy and Infectious Diseases (NIAID) granted $10 million over five years for natural history research on acute flaccid myelitis (AFM).

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[kimskollam]

Best Pediatric Neurology Hospital In Kollam | KIMSHEALTH Hospital

Pediatric Neurology refers to the branch of medicine that is focused diagnosing and treating the conditions of the nervous system in infants and children. With over a decade of experience and expertise in handling such cases, our doctors are known to treat conditions of the brain, the peripheral and the autonomic nervous system, spinal cord, muscles and blood vessels.

The disorders of the nervous system could range from seizures to autism and brain tumors. With comprehensive care for all conditions, KIMSHEALTH is regarded as one among the top hospitals in Kerala to offer Pediatric Neurology

[heardatmedschool]

*Professor shows video of newborn in State 3 of consciousness*

Student: Huh, that’s actually how I’m feeling right now.

[froshele]

today in the wild I came across a phrase to the effect "...And this [pair of ethical axioms about what constitutes quality of life for purposes of discussion about disability and coma prognosis, based on the opinion of one person who has not ever been in a coma or disabled thereafter] suggests that maybe, just maybe, [relevantly comatose or recovering or disabled] people may have quality of life sufficient to make them ethically relevant"

that's ... not, um, normally considered to be what makes people "ethically relevant" in the world where all the people are and there's sunshine and grass and things, but, you know what, ok jennifer, A for effort! :) gold star for you, philosopher extraordinaire, moral lodestar for people unsure what to do with granny, paragon of ethical conduct!

[teachingrounds]

A posterior fossa tumor arising from the fourth ventricle in a child is likely an ependymoma (image 1, Case courtesy of Jini P Abraham, Radiopaedia.org, rID: 98653).

A tumor arising from the brainstem, particularly the pons, is likely a diffuse midline glioma, although pilocytic astrocytomas and gangliogliomas can also arise here (image 2, Case courtesy of Jeremy Jones, Radiopaedia.org, rID: 68486).

[anuraghospital]

Anurag Multi Speciality Hospital offers comprehensive and compassionate care to patients of all ages. Our expert staff is made up of experienced physicians, nurses, and health care professionals who are dedicated to providing the highest quality of care.

For more information: Call us : +919951974147

[ivipharmacy]

IVI Pharmacy is a compound pharmacy that provides customized medication to treat conditions across the fields of dermatology, hematology, immunology, neurology, oncology, pediatrics, rheumatology, and more to patients in Los Angeles, CA.

Our team of pharmacists and medical professionals use advanced pharmaceutical equipment, technology, and techniques to provide high quality medication for patients diagnosed with a range of conditions. Additionally, we provide sterile IVs to patients and medical facilities.

IVI Pharmacy is committed to serving the medical needs of the local community and ensuring patients receive the highest quality of medications without the limitations of a retail pharmacy.

[multispecialityhospitalinindore]

Dental Hospital in Indore | Vivek Memorial Hospital Pvt. Ltd.

Are you looking for a dental Hospital in Indore? Vivek Memorial Hospital provides every type of high-quality dentistry. Schoolchildren, adults, and seniors can all benefit from preventative dentistry programs offered by the department’s highly qualified and knowledgeable staff. For more information, vist: https://vivekmemorialhospital.com/service/dental-department-dentistry/

[medical-education-career]

Why pursue a Doctor of Medicine?

Pursuing a doctor of medicine degree can be beneficial and a valuable investment for aspiring medical professionals. Here are some key benefits:

Attractive Salary Range: MD degree holders often earn competitive salaries, with the average salary for doctors in India being around ₹5,00,000 - ₹7,00,000 lakhs per annum approx.

Job Security: A career in medicine is among the most secure professions globally. The demand for doctors remains constant, regardless of circumstances like pandemics or natural disasters. This ensures long-term job stability.

Enhanced Patient Trust: Specializing in a Doctor of Medicine builds greater trust with patients.

Opportunities in Prestigious Organizations: MD graduates have the opportunity to work in well-known companies and institutions, such as Apollo Hospital, Fortis Hospital, Sun Pharma, Ranbaxy, and more, across various sectors.

Global Job Opportunities: MD graduates are in high demand worldwide, with ample job opportunities in diverse locations.Readmore

[bestneurologistinindore]

Best Neurology Services in Indore | Maitry Neuro Care Centre - Dr Indu Bhana 

Maitry Neuro Care Centre provides best neurology services in Indore like migraine, backache, neck pain, numbness, cervical pain, multiple sclerosis, and brain hemorrhage treatment. Book an online appointment with the best neurology specialist, call now +91-9301895907, +91-7725921197

[shekhawatiurologyhospitaljaipur]

IVF hospital in jaipur

Looking for the IVF hospital in Jaipur? Trust our experienced specialists to guide you through every step.

[drsnehapelviphysio]

Advanced Shoulder Rehabilitation Techniques for Athletes For athletes, shoulder injuries can be a significant setback. Effective rehabilitation is crucial to not only regain strength and mobility but also to prevent future injuries. At Dr. Sneha Life Active Clinic in Kharadi Pune, advanced shoulder rehabilitation techniques are tailored to help athletes recover quickly and return to peak performance.

Understanding Shoulder Injuries in Athletes Athletes are prone to shoulder injuries due to the high demands placed on this complex joint. Common injuries include rotator cuff tears, shoulder impingement, and labral tears. Effective rehabilitation is key to ensuring a full recovery, minimizing downtime, and enhancing sports performance.

The Importance of a Personalized Rehabilitation Plan A personalized rehabilitation plan is essential for athletes to address the specific demands of their sport and individual needs. At Dr. Sneha Life Active Clinic, our approach involves a thorough assessment of the injury, the athlete's biomechanics, and their goals for recovery. This personalized approach ensures that every aspect of the injury is addressed, from pain management to functional recovery.

Advanced Rehabilitation Techniques Manual Therapy: Manual therapy is a hands-on technique that involves manipulating muscles and joints to reduce pain and improve mobility. This technique is particularly effective for restoring range of motion in the shoulder. At our clinic in Kharadi Pune, manual therapy is integrated into the rehabilitation plan to ensure optimal recovery.

Sports Injury Therapy: Tailored sports injury therapy is crucial for athletes recovering from shoulder injuries. This therapy focuses on exercises that mimic sports-specific movements, helping athletes regain strength, stability, and coordination. Our clinic in Pune provides sports injury therapy that is customized to the athlete's sport, whether it’s cricket, tennis, or swimming.

Neurological Rehabilitation: For athletes who have sustained nerve-related shoulder injuries, neurological rehabilitation plays a vital role. This involves exercises and therapies that target nerve function, muscle coordination, and proprioception, helping athletes regain full control over their shoulder movements.

Pain Management: Effective pain management is a cornerstone of shoulder rehabilitation. Techniques such as ultrasound therapy, electrical stimulation, and cryotherapy are utilized at our clinic in Kharadi Pune to alleviate pain and inflammation, facilitating a quicker recovery process.

Sports Performance Enhancement: Beyond rehabilitation, our focus extends to enhancing sports performance. Strengthening exercises, flexibility training, and conditioning programs are incorporated into the rehabilitation process to ensure that athletes not only recover but also return to their sport stronger and more resilient.

The Role of Post-Surgical Rehabilitation For athletes who have undergone shoulder surgery, post-surgical rehabilitation is crucial. At Dr. Sneha Life Active Clinic, we provide comprehensive post-surgical rehabilitation programs that focus on restoring full function, reducing scar tissue, and preventing re-injury. These programs are designed to help athletes transition smoothly from surgery back to their sport.

Injury Prevention and Future Care Injury prevention is as important as rehabilitation. Our clinic in Kharadi Pune emphasizes education on proper techniques, body mechanics, and conditioning programs to help athletes avoid future shoulder injuries. Personalized physio plans are developed to ensure long-term shoulder health and optimal performance.

Incorporating advanced shoulder rehabilitation techniques into an athlete's recovery plan is essential for a successful return to sport. At Dr. Sneha Life Active Clinic in Kharadi Pune, our team is dedicated to providing the highest standard of care, ensuring that athletes receive the comprehensive rehabilitation they need to get back to doing what they love, stronger and more confident than ever before.

Life Active Physiotherapy Clinic

Address: Office 201, Gera Park View Society, behind Eon IT Park, Kharadi, Pune, Maharashtra 411014

Phone: 083902 36030

[alpinelogy]

I love occasionally getting czech tiktoks cause I just got one about a herd of mouflons (?) in one of the hospitals here. Yet to get by citizenship revoked i remembered which one has them

[diginerve]

What is Hydrocephalus? What is the Main Cause of Hydrocephalus

Medical science is complex, it includes studying topics like diseases, causes, and treatments to help people live healthy lives. One such topic that is crucial to understand in detail is Hydrocephalus. 

So, let’s understand the basics about the subject and then we will discuss how you can grab in-depth information and study resources about the subject.

What is Hydrocephalus? 

Hydrocephalus is a chronic neurological disorder where the fluid (Cerebrospinal fluid) builds inside the brain.

Though the Cerebrospinal fluid is already present inside the brain and acts as a caution, the excess can permanently damage the brain. It puts pressure on the skull and squashes surrounding brain tissue, which causes problems with physical and mental development. If untreated, it is usually fatal. 

The condition is primarily common in infants or people older than 60. The common symptoms of hydrocephalus in infants include:

Increase in the size of an infant's head

A bulge or tense soft spot on the top of the head

Nausea and vomiting

Sleepiness or sluggishness

Poor eating

Seizures

Eyes fixed downward

Problems with muscle tone and strength.

The following are the more common symptoms of hydrocephalus among adults 60 and older:

Loss of bladder control

Memory loss

Progressive loss of reasoning skills.

Trouble walking

Poor coordination or balance.

Remember: The systems among toddlers, children, and middle-aged adults can differ.

Types of Hydrocephalus 

The following are the different types of Hydrocephalus:

Congenital hydrocephalus: It is caused by a brain malformation or birth defect that causes excessive cerebrospinal fluid (CSF) to accumulate in brain cavities, called subarachnoid space.

Acquired hydrocephalus: Usually resulting from a stroke, brain tumour, meningitis, or a severe head injury.

Communicating hydrocephalus: A condition when the flow of CSF is blocked after leaving the ventricles. Because CSF can still flow between the brain’s ventricles, it is also called “communicating.”

Non-communicating hydrocephalus: Also known as obstructive hydrocephalus, this type occurs when the narrow pathways connecting the ventricles become blocked.

Normal pressure hydrocephalus: NPH affects primarily those aged 60 and up. It can arise following a stroke, injury, infection, surgery, or hemorrhage. 

Hydrocephalus ex-vacuo: Occurs after a stroke, traumatic brain injury, or degenerative disease. In this type, as brain tissue shrinks, the brain's ventricles become larger.

Now that we know the symptoms and types of hydrocephalus, let's dive in to learn about the causes so we can understand the problem better.

What is the Main Cause of Hydrocephalus

There are two distinct cause categories into which hydrocephalus can be classified:

Congenital

Acquired

Congenital hydrocephalus is the result of both genetic and environmental factors working together during foetal development. The following are the main reasons for congenital hydrocephalus:

Spina bifida and other brain and spinal cord (neural tube) defects.

A narrowing of the small passage between the third and fourth ventricles of the brain (aqueductal stenosis).

Complications of premature birth, such as bleeding within ventricles.

Mom has an infection during pregnancy.

On the other hand, Acquired hydrocephalus develops after birth and can affect people of all ages. Below, we have listed the most common causes of acquired hydrocephalus:

Brain or spinal cord tumours

Head trauma

Stroke

Meningitis or other infections of your brain or spinal cord.

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Enroll in an online pediatrics course.

Without the assistance of a professional, it can be challenging to find the study material and understand the basics of the subject. 

That is why Dr. Piyush Gupta designed this course for students preparing for an MD in pediatrics.

The course includes pediatrics video lectures along with other crucial resources. 

So start your journey toward a good hold on the subject, and enroll in the course now!