#Metabolic Disorders

[assiconicillnesschronic]

I had such good results with the few initial otc pain relief patches I bought that I went ahead and ordered a collection of them to try out. $17.47

Pharmacy run for levothyroxine and Wellbutrin $11.11

Restocked my car first aid kit with Liquid I.V.powder. I don't love Liquid I.V. and don't use it at home. I think it's too expensive for an everyday hydration boost. I do keep it in the car and it's saved me and others from the Atlanta heat several times. $10.79

I ended up not ordering more cgms yet. I have an entire drawer of assorted meters, testing strips, lancets, wipes etc I am going to try to use up most of that first. Should save me a little money and hopefully clean that drawer up cause it's.... It's alot.

Total medical spend for 2024: $3,651.37

[ashleywool]

This is what I mean when I say "nothing is weird in New York."

That said, the phrases "boa constrictor" and "Upper West Side apartment" should not ever exist together in the same sentence.

On an unrelated note, I had a lot of bloodwork done recently. My blood pressure has been hovering around 90/60 for most of my adult life, and now it's in the hypertension zone, my triglycerides and fasting blood glucose are way higher than it makes sense for a non-diabetic who's never been overweight, and my cortisol levels are astronomical in ways that can't just be chalked up to being autistic or living in a world where boa constrictors randomly show up in NYC kitchen sinks.

Soooo, based on those things and a lot of other things, I think I have Cushing's disease and I think the culprit is a pituitary tumor.

Just feel like I should put that in writing somewhere. If I'm wrong, I'm sure there will be education in there worthy of sharing, and if I'm right, then I'll be gloating about it for the rest of my life.

Because it will be the second time in the last two years I've successfully diagnosed myself with something obscure and uncommon that doctors would later confirm to be accurate.

The first time was when I was experiencing cytokine storms after recovering from COVID in late 2022--my vitals were back to normal, but every time I stopped taking prednisone, my nervous system was gaslighting me into feeling like I still had symptoms. That usually only happens with cases far more severe than mine (mine was awful, but not hospitalization-awful, thank you Pfizer), but guess which population has a tendency towards abnormal immune responses? I felt like a conspiracy theorist when I suggested this to my PCP but she was like "that totally makes sense, try one more round of prednisone, that should do it," and IT DID.

Ever since then, if I'm looking up symptoms or conditions, I tag "and autism" onto the search terms. Which kinda sucks sometimes. Because research has suggested there IS a correlation between autism and pituitary abnormalities too, and I am interested in digging deeper into it...

But even in non-clinical sources, people always write these things as if they never think autistic people are actually going to read them. It's always "if you're a parent or caregiver and you observe this," and never "if you're an autistic person and you experience this." It's got the same energy as the research I've done about food intolerances in cats--Tex has had some gastrointestinal issues recently, but he can't TELL me what he's feeling or speculate about the source of his symptoms or do research on his own. I think the world is starting to understand that autistic people are not cats, but sometimes I wish the healthcare sector would catch up faster.

Anyway. Uh.

WHO IS KEEPING A FREAKING BOA CONSTRICTOR ON THE ISLAND OF MANHATTAN I HAVE SO MANY QUESTIONS AND ALL OF THEM ARE "WHY"

[bpod-bpod]

Growth Limiting

Mouse model of the rare genetic metabolic disorder lysinuric protein intolerance reveals details of skeletal growth failure mechanisms

Read the published research paper here

Image from work by Bridget M. Stroup and colleagues

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in and on the cover of Disease Models & Mechanisms, August 2023

You can also follow BPoD on Instagram, Twitter and Facebook

[hormonesclinics]

Managing Obesity: Tips for a Healthier Lifestyle

Obesity is a major health problem affecting millions of people worldwide. This is a condition in which excess body fat builds up in the body, leading to a variety of health problems such as diabetes, heart disease, and certain types of cancer. It can be treated with medical intervention. This blog post will go into detail about different ways to treat obesity.

Diet

One of the most important factors in managing obesity is diet. A healthy and balanced diet is essential for maintaining a healthy weight. It is important to eat a variety of nutrient-dense foods such as fruits, vegetables, whole grains, lean proteins, and healthy fats. Avoid processed foods, sugary drinks, and foods high in saturated and trans fats.

Exercise

Physical activity is also important in managing obesity. Exercise helps burn calories, improve muscle mass, and boost metabolism. It is recommended to aim for at least 150 minutes of moderate-intensity exercise per week. This can be achieved through activities such as brisk walking, cycling, swimming, or strength training.

Behavioral changes

Making behavioral changes can also help manage obesity. This includes setting realistic goals, monitoring progress, and staying motivated. It is important to identify triggers for overeating and develop strategies to overcome them. Seeking support from friends and family, joining a support group, or consulting with a healthcare professional can also be helpful.

Medications

In some cases, medications may be prescribed to manage obesity. These medications work by reducing appetite, blocking the absorption of fat, or increasing feelings of fullness. However, medications should always be used in combination with diet and exercise.

Surgery

For those with severe obesity, surgery may be an option. Bariatric surgery is a type of surgery that can help reduce weight and improve overall health. This surgery involves reducing the size of the stomach or bypassing a portion of the small intestine to limit the amount of food that can be consumed.

Summary

obesity is a serious health condition that can be managed with the right lifestyle changes and medical interventions. A healthy diet, regular exercise, behavioral changes, and medical treatments can all help manage obesity and improve overall health. It is important to seek support from healthcare professionals and loved ones to ensure long-term success in managing obesity.

For More information Visit: www.hormoneclinic.in

[fasting4weightloss]

[besttosuggest]

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[atlxolotl]

A new study has found that not sticking to a regular bedtime and wakeup schedule—and getting different amounts of sleep each night—can put a person at higher risk for obesity, high cholesterol, hypertension, high blood sugar and other metabolic disorders. In fact, for every hour of variability in time to bed and time asleep, a person may have up to a 27% greater chance of experiencing a metabolic abnormality.

[gauricmi]

Global Leigh Syndrome Treatment market is Estimated to Witness High Growth Owing to Increasing Disease Awareness

The global Leigh syndrome treatment market is expected to exhibit significant growth due to rising prevalence of the rare genetic disorder. Leigh syndrome is a rare and aggressive neurological disorder caused by mutations in mitochondrial DNA or nuclear genes involved in mitochondrial biogenesis and respiration. The characteristic symptoms of Leigh syndrome include developmental delay, loss of motor skills, weakness, vision problems, and respiratory issues. Currently, there is no definitive treatment for Leigh syndrome. Treatments mainly focus on managing symptoms by targeting the underlying cause. Therapies primarily include vitamin and nutritional supplements, physical and occupational therapy, and medications targeting respiratory and neurological complications.

The global Leigh syndrome treatment market is estimated to be valued at US$ 272.9 million  in 2024 and is expected to exhibit a CAGR of 6.7% over the forecast period from 2024 to 2031. Key Takeaways Key players operating in the Global Leigh Syndrome Treatment Market Growth are Abliva AB, PTC Therapeutics, VAKS Pharma, MITOCH, Medley Pharmaceuticals Ltd., Khondrion BV, OMEICOS THERAPEUTICS GMBH. , Edison Pharmaceuticals, Inc. , Dainippon Sumitomo Pharma Co. Ltd., Taysha GTx, PicnicHealth (AllStripes), Takeda Pharmaceutical Company , Biogen, Ionis Pharmaceuticals, Inc., Sarepta Therapeutics, Inc., and MECOSON LABS PRIVATE LIMITED. The global Leigh syndrome treatment market is expected to witness lucrative growth opportunities due to increasing research funding for rare disease drug development and growing orphan drug designations. Furthermore, advancements in understanding the genetics and underlying mechanisms of Leigh syndrome are likely to aid the development of novel targeted treatment options. Key players are actively focusing on expanding their geographical presence through collaborations and partnerships with regional healthcare providers to cater to the growing patient population worldwide. For instance, in 2021, Khondrion partnered with Taysha Gene Therapies to accelerate the clinical development of KH-176, a gene therapy drug candidate for Leigh syndrome. Market Drivers The primary driver propelling the global Leigh syndrome treatment market growth is increasing disease awareness driven by advocacy programs by patient support groups such as United Leukodystrophy Foundation and Cure Sanfilippo Foundation. Growing government efforts to provide orphan drug incentives and streamline the approval process for rare disease drug candidates are also expected to encourage pharmaceutical companies to invest in Leigh syndrome drug R&D.

Get More Insights On This Topic: Leigh Syndrome Treatment Market

[drforambhuta]

Preventing Chronic Diseases with Turmeric:

1. Addressing Chronic Inflammation: Chronic inflammation contributes to various chronic diseases like heart disease, cancer, Alzheimer's, and metabolic disorders. Curcumin, known for its strong anti-inflammatory properties, shows potential in reducing inflammation and associated health risks. Studies indicate its ability to suppress inflammatory molecules, potentially alleviating conditions like arthritis, inflammatory bowel disease, and asthma.

2. Supporting Heart Health: Heart disease remains a leading cause of mortality globally. Curcumin's cardiovascular benefits include improvements in factors linked to heart disease such as hypertension, dyslipidemia, and endothelial dysfunction. Research suggests it may lower blood pressure, decrease LDL cholesterol, and enhance endothelial function, thus promoting heart health and reducing cardiovascular risks. Its antioxidant properties may also combat oxidative stress, a major contributor to heart disease.

3. Cancer Prevention and Treatment: Cancer, characterized by uncontrolled cell growth, poses a significant health challenge. Although further research is necessary, initial studies suggest curcumin's potential in inhibiting tumor growth, inducing apoptosis, and suppressing tumor-promoting pathways. It shows promise in preventing and treating various cancers like breast, prostate, colon, lung, and pancreatic cancer, possibly enhancing conventional cancer therapies.

4. Enhancing Brain Health: With aging populations, age-related cognitive decline and neurodegenerative diseases like Alzheimer's and Parkinson's are on the rise. Curcumin's neuroprotective properties may preserve brain health by promoting neuroplasticity, increasing brain-derived neurotrophic factor (BDNF) production, and reducing amyloid plaque and tau tangle accumulation, hallmarks of Alzheimer's. Its anti-inflammatory and antioxidant effects may mitigate neuroinflammation and oxidative stress, key contributors to neurodegeneration.

5. Metabolic Health and Weight Management: Obesity and metabolic syndrome increase the risk of chronic diseases like type 2 diabetes and cardiovascular disease. Curcumin's metabolic benefits extend beyond inflammation and oxidative stress reduction, including improvements in insulin sensitivity, glucose metabolism, and lipid profile regulation. Research suggests it may help regulate blood sugar levels, reduce insulin resistance, and aid in weight loss, potentially benefiting individuals with obesity or metabolic disorders.

6. Joint Health and Arthritis Management: Arthritis, characterized by joint inflammation and pain, affects millions worldwide. Curcumin's anti-inflammatory properties may alleviate arthritis symptoms and prevent its onset by reducing joint inflammation and oxidative stress. Studies indicate its potential in improving symptoms of osteoarthritis and rheumatoid arthritis, including pain and stiffness, while its antioxidant effects may protect cartilage and promote joint health.

7. Promoting Digestive Health: Digestive disorders like irritable bowel syndrome (IBS) and inflammatory bowel diseases impact quality of life. Curcumin's anti-inflammatory and antimicrobial properties may alleviate symptoms and promote gut health. Research suggests it could reduce symptoms of IBS, including abdominal pain and bloating, by modulating gut inflammation and restoring microbial balance, while its antioxidant effects may protect the gastrointestinal tract and aid in healing intestinal mucosa.

8. Supporting the Immune System: A robust immune system defends against infections and diseases. Curcumin's immunomodulatory properties may enhance immune function and prevent infections by reducing inflammation. Studies indicate its ability to stimulate immune cell activity, improving pathogen recognition and elimination. Additionally, its antimicrobial properties may inhibit the growth of bacteria, viruses, and fungi, reducing infection risks.

You can find some of the best hospitals in Mumbai offering regular health checkups for the early detection and management of chronic diseases, such as a regular full body health checkup at Jaslok Hospital Mumbai.

[the2amrevolution]

It (was) Rare Disease Day - the last day of February, this year the rarest day of the year.

When I first started having signs that something was definitely wrong in October of 2015, I never would have thought this is where it would lead me. Even a year ago, I wouldn't have thought I'd be researching rare metabolic disorders and getting whole genome sequencing.

The progressive nature of my illness really amplified in the last year, especially from July onward. When taking what should have been a perfectly safe supplement turned into an express train towards megaloblastic anemia, thrombocytosis, and liver failure, it was lucky timing of an appointment that spared me from anything beyond increased fatigue, worsened sleep quality, and the sudden appearance of deep lines under my eyes. I look like I've aged a decade in less than a year.

This strange reaction led me down a rabbit hole that led to another rabbit hole that suddenly led me to having an explanation for everything that happened from 2015 onwards - the symptoms, their progression, why some things helped, why some things didn't.

Because other testing was inconclusive, I await my DNA results while self treating with sublingual methylcobalamin and pyridoxal phosphate, which has given me some improvement since mid-December.

This past 9 years has completely altered my relationship with my sense of self, my body, and the world as a whole. Illness has completely altered my life and taken away any vision of my future I once had. The support of family and friends has kept me going. Without them I never would have made it this long. I wouldn't have been able to hold onto joy or hope without them, and I definitely wouldn't be able to try to claw back what's been taken from me.

I hope for next year's Rare Disease Day I will be sharing a success story of finding a metabolic specialist to support me and of a journey of recovery.

For now, I just have to keep trying to take care of myself and advocate for myself as best I can.

Remember, "rare" doesn't mean "impossible." Rare is real. We are zebras not unicorns.

And treat yourself to a zebra cake.

[tenth-sentence]

The disorder's consequences – liver enlargement, cataracts, mental retardation, and, not uncommonly, infant death – could be avoided with early detection and the administration of a galactose-free diet.

"In the Name of Eugenics: Genetics and the Uses of Human Heredity" - Daniel J. Kevles

[thenotoriouserg]

Fiiiiine, I'll make this stupid breakfast, for my stupid insulin resistance, to regulate my stupid blood glucose and reduce my stupid daily symptoms noticeably. Fiiiiiine.

[cmipooja]

Insulin Sensitizers Market Is Estimated To Witness High Growth Owing To Increasing Prevalence of Insulin Resistance

The global Insulin Sensitizers Market is estimated to be valued at US$ 15.09 billion in 2023 and is expected to exhibit a CAGR of 5.5% over the forecast period 2023-2030, as highlighted in a new report published by Coherent Market Insights. Market Overview: Insulin sensitizers are medications that help improve insulin sensitivity and reduce blood sugar levels in individuals suffering from insulin resistance. These drugs are primarily used in the treatment of type 2 diabetes and metabolic syndrome. Insulin resistance occurs when the body's cells become inefficient at using insulin, leading to high blood sugar levels. Insufficient insulin sensitivity can also result in other health complications such as obesity, hypertension, and cardiovascular diseases. Insulin sensitizers play a crucial role in managing insulin resistance by enhancing the body's response to insulin and facilitating glucose uptake by the cells. These medications help regulate blood sugar levels, decrease the risk of diabetes-related complications, and improve overall metabolic health. The growing prevalence of insulin resistance, coupled with the rising global burden of diabetes, is driving the demand for insulin sensitizers. Market Key Trends: One key trend observed in the insulin sensitizers market is the increasing focus on combination therapies. Healthcare providers are increasingly prescribing combination therapies that include insulin sensitizers along with other diabetes medications to achieve optimal glycemic control. The combination approach allows for better blood glucose management, reduced side effects, and improved patient adherence to treatment regimens. For example, a common combination therapy includes a sulfonylurea (such as glimepiride or glipizide) along with a thiazolidinedione (such as pioglitazone). The sulfonylurea stimulates insulin secretion from the pancreas, while the thiazolidinedione improves insulin sensitivity and reduces insulin resistance. This combination therapy offers a dual mechanism of action, resulting in better glycemic control in patients with type 2 diabetes. PEST Analysis: - Political: Government policies and regulations related to drug pricing and reimbursement can impact the insulin sensitizers market. Price controls or changes in reimbursement policies can affect the financial viability of manufacturers and influence market dynamics. - Economic: The growing healthcare expenditure, increasing disposable income, and rising healthcare awareness are favorable economic factors that contribute to the growth of the insulin sensitizers market. - Social: Lifestyle changes, sedentary behaviors, unhealthy dietary habits, and the high prevalence of obesity contribute to the rising incidence of insulin resistance and diabetes globally. - Technological: Advancements in drug delivery systems, such as insulin pens and pumps, have improved patient convenience and adherence to insulin sensitizers. Key Takeaways: 1: The Global Insulin Sensitizers Market Size is expected to witness high growth, exhibiting a CAGR of 5.5% over the forecast period. This growth is primarily driven by the increasing prevalence of insulin resistance and the rising global burden of diabetes. Insulin sensitizers play a crucial role in managing insulin resistance and improve overall metabolic health. 2: Regionally, North America is anticipated to be the fastest growing and dominating region in the insulin sensitizers market. The region's high prevalence of diabetes, well-established healthcare infrastructure, and favorable reimbursement policies contribute to its market dominance. 3: Key players operating in the global insulin sensitizers market include Eli Lilly and Company, Novo Nordisk, Sanofi, Merck & Co., Bristol Myers Squibb, AstraZeneca, Boehringer Ingelheim, Johnson & Johnson, and Takeda Pharmaceutical. These companies focus on product innovation, strategic collaborations, and geographic expansion to gain a competitive edge in the market.

[johnnywithaker]

Proven Ways To Boost Your Metabolism

Have you tried to eat healthy, exercised regularly and even committed to fasting for diet purposes…..but still…the weight never budged?!

You need to try this….The Ancient Mediterranean Ritual.

The benefits include:

Boosts and improves metabolism

Detoxifies and purifies the body

Healthy weight loss

Enhances fat burning

Boosts energy levels

Reduces bloating

ETC

Click Here for Immediate Access to The Ancient Mediterranean Ritual that is changing the lives of many today!

https://bit.ly/3rupaNT

[healthglorious]

Eat Early for Better Blood Sugar Control

Introduction For general health and well-being, it’s imperative to maintain healthy blood sugar levels. Low blood sugar levels can cause symptoms including weariness, dizziness, and disorientation, while high blood sugar levels can raise the chance of developing type 2 diabetes, heart disease, and other metabolic problems. Despite the fact that there are numerous elements that affect blood sugar…