#Phenacetin UK

[benzocaine-supplier]

10 Sins of Phenacetin Uk and How to Avoid Them

Phenacetin is a pain-relieving and fever-reducing drug, which was widely used following its introduction in 1887. It was withdrawn from medicinal use as dangerous from the 1970s (e.g, withdrawn in Canada in 1973, and by the US Food and Drug Administration in 1983). Phenacetin powder has been used as a cutting agent to adulterate cocaine in the UK and Canada, due to the similar physical properties. In the UK, benzocaine, lidocaine and Phenacetin UK are the most common chemicals used to “cut” illegal drugs, especially cocaine.

[bmkoilpmkoil]

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[benzocaine-supplier]

Find Out High-Quality Phenacetin UK Which Meet Needs

Phenacetin UK was used for a long time as a painkiller and fever reducer in both human and veterinary medicine. It was first used to treat pain in 1887. It was used in pain relievers until it was stuck in kidney disease nephropathy because analgesics were used poorly. In the past, arrangements for hair blanching utilized phenacetin as a stabilizer for hydrogen peroxide.

[benzocainesupplier]

Benzocaine is considered as the active ingredient in most of the anesthetic ointments for oral ulcers and many numbers of over-the-counter products. These are used in the wide application in the modern-day.

[drugusersbible]

SOMETHING ABOUT YOUR COCAINE I was at a loose end for a couple of hours so I started to look at the contents of the cocaine samples submitted to a well known UK lab. Of focus was the issue of what cocaine is commonly bulked or cut with (not including other mainstream drugs). This was nothing to do with my book: it was purely for academic interest as an occasional user.

162 samples were submitted as cocaine from 1st September 2020 to the current date (April 2021). From these 50 (31%) of the samples were listed solely as cocaine, with no other recorded content.

I broke the rest down into two sets: those which returned a single addition, and those which returned multiple additions. The figures were as follows:

Single Addition (64 samples in total):

21 (13.0%) = Benzoylecgonine 17 (10.5%) = Levamisole 10  (6.2%) = Norcocaine 7   (4.3%) = Benzocaine 6   (3.7%) = Phenacetin 1   (0.6%) = Paracetamol 1   (0.6%) = Metformin 1   (0.6%) = Lidocaine

Multiple Additions (48 samples in total)

10 (6.2%) = Levamisole + Benzoylecgonine 7  (4.3%) = Levamisole + Norcocaine 5  (3.1%) = Levamisole + Benzoylecgonine + Norcocaine 4  (2.5%) = Benzoylecgonine + Norcocaine 3  (1.9%) = Benzoylecgonine + Ecgonine methyl ester 2  (1.2%) = Benzocaine + Norcocaine 2  (1.2%) = Phenacetin + Benzocaine 2  (1.2%) = Phenacetin + Norcocaine 2  (1.2%) = Benzoylecgonine + Norcocaine + Ecgonine methyl ester 1  (0.6%) = Levsole + Phenacetin 1  (0.6%) = Phenacetin + Norcocaine + Benzocaine 1  (0.6%) = Tropacocaine + Norcocaine + Benzoylecgonine + Ecgonine methyl ester 1  (0.6%) = Levamisole + Norcocaine + Benzocaine 1  (0.6%) = Levamisole + Norcocaine + Benzoylecgonine + Tropacocaine 1  (0.6%) = Benzocaine + Ecgonine methyl ester 1  (0.6%) = Phenacetin + Ecgonine methyl ester + Benzoylecgonine + Caffeine + Benzocaine 1  (0.6%) = Levamisole + Metformin + Norcocaine + Benzoylecgonine 1  (0.6%) = Levamisole + Benzoylecgonine + Norcocaine + Ecgonine methyl ester 1  (0.6%) = Benzoylecgonine + Procaine + Norcocaine + Ecgonine methyl ester 1  (0.6%) = Levamisole + Benzoylecgonine + Phenacetin + Ecgonine methyl ester

It should be noted that not all of these are bulking or cutting agents: some simply result from degradation or production issues. Referring to them as additions or additives is probably not the best terminology.    

This isn't the biggest of sample sizes but what surprised me was that some samples contained multiple additions. I can't speculate why that would ever happen, other than perhaps different vendors adding different agents as the cocaine moved down the supply chain. It has to be said though that this does represent a very small percentage of the samples.

What didn't surprise me though was that levamisole ranked so highly (present in 28% of all samples); although this wasn't as high as I feared. It is widely known that this is used to treat parasitic worm infections, and that it is a very bad idea to snort large volumes. I was also surprised at the low ranking of lidocaine, as I expected it to be the primary anesthetic/agent. Perhaps I am showing my age again, which also leads me to wonder what happened to procaine.

Refs: The Drug Users Bible [Amazon: https://www.amazon.com/dp/099559368X]

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High Purity Pharmaceutical intermediates(API) :

Pregabalin,CAS 148553-50-8

Phenacetin,CAS 62-44-2

Melanotan II Mt2 CAS 121062-08-6 

Lidocaine,CAS 137-58-6

Lidocaine hydrochloride,CAS 73-78-9

Larocaine/Dimethocaine（DMC）CAS 94-15-5

Dimethocaine Hydrochloride CAS 553-56-9

Boric acid,CAS 11113-50-1

Levamisole (hydrochloride),CAS 16595-80-5

Tetracaine,CAS 94-24-6

Tetracaine hydrochloride CAS 136-47-0

Tetramisole hydrochloride,CAS 5086-74-8

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Procaine,CAS 59-46-1

Benzocaine,CAS 94-09-7

Benzocaine hydrochloride,CAS 23239-88-5

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Valerophenone,CAS 1009-14-9

HEXANOPHENONE,CAS 942-92-7

4-Methylpropiophenone,CAS 5337-93-9

4-Ethylpropiophenone,CAS 27465-51-6

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[benzocaine-supplier]

Benzocaine – Fast-Acting Medicine for Minimizing Feeling

Many medical professionals want the perfect anesthetic to minimize sensitivity and block the local nerve effect. Medical experts wish to use benzocaine online for everything from minimizing pain caused by injury to controlling sensitivity.On the other hand, Phenacetin UK may utilize as an analgesic and fever-reducing remedy in veterinary and human medicine. https://writeupcafe.com/benzocaine-fast-acting-medicine-for-minimizing-feeling/

[phenacetinpowder]

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[juniperpublishers-ttsr]

Revisiting Aspirin, Paracetamol and Ibuprofen: Discovery of Synthetic Procedures and Mode of Actions

Abstract

In this article, we will outline the historical background of the popular medicines Aspirin, Paracetamol and Ibuprofen which have been widely used for decades for their desired therapeutic effects as Analgesics, Antipyretics and Anti-inflammatory agents. We will discuss the synthetic procedures and mechanism of actions of these well-known drugs, achieved through systematic research on medicinal chemistry as well as cellular biology and pharmacology.

Keywords:Aspirin; Paracetamol; Ibuprofen; Discovery; Metabolism

    Introduction

By the end of the nineteenth century, scientific approach towards development of medicine made it possible to isolate drugs like Quinine, Ipecacuanha, and Aspirin etc. which were mainly derivatives of Natural Products. In modern times, screening of synthetic drug and lead chemical identification is an extremely complex process which requires active participation of disciplines like organic chemistry, biochemistry, microbiology, physiology, pharmacology. Even after discovery, it takes ages for the candidate drug to come for marketing. It has often been seen that establishment of proper mechanism of action of therapeutic effects involves collaborations of different research groups, from different countries, even from different time periods. In this article, we will outline the developmental process of the popular medicines Aspirin, Paracetamol and Ibuprofen which have been widely used for decades for their desired therapeutic effects as Analgesics, Antipyretics and Anti-inflammatory agents. The terms Analgesics and Analgetic drugs are often used interchangeably to describe a diverse group of pain medications. Antipyretics are the drugs that lower body temperature increased by infections or other diseases but have no effect on normal body temperature. Anti-inflammatory agents are the drugs used to diminish or reduce inflammation and pain associated with it. Here we will highlight the discovery of the laboratory synthetic procedures and mechanism of actions of these well-known drugs.

    Aspirin

Willow bark extract was recognised as folk medicine from the mid-eighteenth century for treatment of fever and pain. Salicylic acid derived from willow bark is one of the oldest analgesics. However, its use can cause gastric irritation and bleeding due to the free phenolic group. This is overcome by masking the phenol as an ester. The compound acetylsalicylic acid known as Aspirin was tested and introduced into medicine by Bayer in Germany in the late 1890s. Heinrich Dreser, Arthur Eichengrün and Felix Hoffmann are recognised as pioneers in the development of acetylsalicylic acid as the drug Aspirin. Bayer’s brand name, Aspirin was named by taking a from acetyl and spirin, comes from an old name for salicylic or spiric acid, derived from its natural source of spirea plants. Synthetically, Salicylic acid is converted to its prodrug Aspirin by acetylation of the phenolic hydroxy group. In human body, Aspirin is mainly converted to salicylic acid by esterases after absorption from the GI tract. This reduces the degree of stomach irritation because lesser amount of salicylic acid encounters the gut wall lining. The drug became popular worldwide and it was sold over the counter in the form of tablets since 1915. It is a common remedy for the relief of headache, muscular pain, rheumatic states, gout, and toothache [1].

Chemical name: Acetylsalicylic acid

Common names: ASPRO, DISPRIN, CARDIPRIN

To prepare aspirin, salicylic acid is reacted with an excess of acetic anhydride. A small amount of a strong acid is used as a catalyst which speeds up the reaction (Figure 1). The product will appear as a solid mass when crystallization is complete, and crystals are collected through vacuum filtration.

Investigations were continued to understand the basic mechanism of Aspirin’s action while clinical trials and other studies in 1960s established that it reduces the risk of heart attack. In 1971, John R. Vane from the Wellcome Research Laboratories, UK discovered the mechanism by which Aspirin exerts its antiinflammatory, analgesic and antipyretic effects [2]. He proved that Aspirin and other non-steroid anti-inflammatory drugs (NSAIDs) inhibit the activity of the enzyme now called cyclooxygenase (COX) which leads to the production of Prostaglandins (PGs), responsible for sensations of pain and processes of fever and inflammation. Aspirin acts by acetylating the hydroxyl of a serine residue in the active site of the COX enzyme. This makes Aspirin different from other NSAIDs (such as Diclofenac and Ibuprofen), which are reversible inhibitors. Moreover, Cyclooxygenase is required for synthesis of Thromboxane, responsible for the aggregation of platelets that form blood clots. So, Aspirin can also function as an efficient anti-clotting agent by irreversibly blocking the formation of Thromboxane in platelets. This entire process is depicted in Figure 2. For discoveries concerning Prostaglandin, the Nobel Prize in medicine in 1982 was awarded jointly to Sune K. Bergström, Bengt I. Samuelsson and John R. Vane.

    Paracetamol

Paracetamol is a common household drug for pain reliever and fever reducer [3]. This aniline derivative is popularly known as Paracetamol (from para-acetyl-amino-phenol) in Europe and most of the rest of the world and as Acetaminophen (from N-acetylpara- aminophenol) in the United States and Japan. The compound was first prepared in 1877 by Harmon Northrop Morse at Johns Hopkins University, but clinically tested on humans by von Mering during 1887. From a historical perspective, Acetaminophen/ Paracetamol and the related drugs such as Acetanilide (Antifebrin: 1886), Phenacetin (1887) were introduced into the market about the same time as Aspirin and the other salicylates. The sale of Aspirin was overshadowed by Phenacetin which established Bayer as a leading pharmaceutical company that time. About half a century later, it was rediscovered that Paracetamol is the active metabolite of both Phenacetin and Acetanilide [4]. After this breakthrough, Paracetamol was successfully marketed in 1953 by Sterling-Winthrop Co. as Panadol. This medicine still continues to be the most widely used analgesic antipyretics with few sideeffects and little interaction with other pharmaceutical agents.

The drug inhibits COX activities in the central nervous system, but it lacks an anti-inflammatory effect because it cannot inhibit COX in the peripheral tissues. So, unlike Aspirin and salicylates, it does not cause gastrointestinal problems or prolonged bleeding time. This family of drug is on the World Health Organization’s List of Essential Medicines, the safest and most effective medicines needed in a health system. Doses of Paracetamol greater than the recommended ones can cause severe liver damage [5].

Common names: ANACIN-3, CALPOL, CROCINE, PANADOL, TYLENOL

For production of Paracetamol, phenol is used as the starting material which is reacted with sodium nitrate giving a mixture of two isomers of which the desired nitration product, 4-nitrophenol (BP: 279°C) can easily be separated by steam distillation. The nitro group is then reduced to amine, giving 4-aminophenol. Industrially direct hydrogenation is used, but in the laboratory scale sodium borohydride serves. Finally, the amine is acetylated with acetic anhydride. The synthesis reaction is shown in Figure 3.

    Ibuprofen

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) belonging to the family of synthetic 2-arylpropionic acids (Profens) that is used for treating pain, fever and inflammation. It is mainly effective for the pain and swelling associated with arthritis. It is a reversible, non-selective COX inhibitor, lowering the level of Prostaglandins via blocking the metabolism of Arachidonic acid in the body. Ibuprofen is administered as a racemic mixture. The human body can convert the inactive (R) form into the active (S) form, so eventually 100% of the Ibuprofen taken becomes active.

Chemical name: [(±)-2-(4-isobutylphenyl)] propionic acid

Common names : BRUFEN, FENLONG, NOVAPRIN, EMFLAM. ADVIL, MOTRIN

The two most popular ways to obtain ibuprofen are the Boot process and the Hoechst process. The Boot process is an older commercial process developed by the Boot Pure Drug Company and patented in 1960s [6]. This synthesis consists of six steps and resulted in unwanted by products as shown in Figure 4. The Boots- Hoechst-Celanese (BHC) synthesis serves as a model that has genuinely contributed to green chemistry [7]. In 1992, the BHC Company developed a new, sustainable synthesis that reduced the number of synthetic steps to half (total three steps) of that in the original Boots Company method (Figure 4). It is noteworthy that the synthesis began with the same first step, e.g. acylation of isobutylbenzene, but utilized anhydrous hydrogen fluoride as both a catalyst and solvent. The reduced amount of unwanted waste due to the generation of only one molecule of water as the byproduct is another achievement of the BHC method. Ibuprofen is the first pharmaceutical compound that was recognized by the U.S. Environmental Protection Agency Presidential Green Chemistry Challenge Awards in 1997.

    Conclusion

During the past century, Aspirin and Paracetamol have occupied a central role in the treatment of fever and pain. Nonsteroidal anti-inflammatory drugs (NSAIDs) have proved to be highly efficient for getting instant relief from pain and inflammation and Ibuprofen remains the first choice for this. With evolving research on biological activity, traditional role of Aspirin has been re-defined leading to the appropriate use of this agent in clinical practice. The green synthesis of Ibuprofen has emerged resulting improved and economical yield. We can conclude that the field of medicinal chemistry based on the studies on cellular biology and pharmacology has covered a long journey to understand the mode of operation and metabolism of these synthetic drugs in the body.

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[onlinebenzocaine1-blog]

Do you need the right quantity of Benzocaine or Phenacetin or any kind of other chemical or powder form? A variety of products and chemicals as well as powder forms are required to formulate a variety of medicines and other things. As far as Benzocaine is concerned, it is a local anesthetic applied topically to the skin and mucous membranes.

[nancylwax]

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Main Products: CAS 1451-82-7 2-Bromo-4'-methylpropiophenone; CAS 1451-83-8 2-Bromo-1-Phenyl-1-Butanone; CAS 20230-59-6 New BMK liquid; CAS 28578-16-7 New PMK liquid; CAS 16648-44-5      BMK Methyl 2-phenylacetoacetate;                                Benzeneacetic Acid(BMK);         CAS 5413-05-8        BMK ETHYL 2-PHENYLACETOACETATE; CAS 13605-48-6      PMK Pmk glycidate; CAS 79099-07-3 1-Boc-4-Piperidone; CAS 40064-34-4      4,4-Piperidinediol hydrochloride; CAS 236117-38-7 2-iodo-1-p-tolylpropan-1-one; CAS 4098-40-2   MITRAGYNINE PICRATE; CAS 51-05-8 Procaine hydrochloride; CAS 62-44-2 Phenacetin; CAS 73-78-9 Lidocaine hydrochloride; CAS 93-02-7 2,5-Dimethoxybenzaldehyde; CAS 94-09-7 Benzocaine; CAS 94-24-6 Tetracaine; CAS 103-90-2 4-Acetamidophenol; CAS 106-96-7 3-Bromopropyne; CAS 110-63-4 BDO 1,4-Butanediol; CAS 123-39-7 N-Methylformamide; CAS 123-75-1 Pyrrolidine; CAS 1009-14-9 Valerophenone; CAS 5086-74-8 Tetramisole hydrochloride; CAS 5337-93-9 4-Methylpropiophenone; CAS 5413-05-8 New BMK Glycidate; CAS 5413-05-8 Ethyl 3-oxo-4-phenylbutanoate; CAS 11113-50-1 Boric acid; CAS 13605-48-6 PMK Glycidate; CAS 14176-50-2 Tiletamine Hydrochloride; CAS 16595-80-5 Levamisole HCl; CAS 19099-93-5 N-CBZ-4-piperidone; CAS 23076-35-9 Xylazine hydrochloride; CAS 37148-48-4 4-Amino-3,5-dichloroacetophenone; CAS 49851-31-2 2-Bromovalerophenone; CAS 148553-50-8 Pregabalin; CAS 171596-29-5 Cialis/tadalafil

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[1738092-blog]

Legalising Drugs:Boon or Bane

The process of legalising drugs has always been controversial, since a majority of the society is in support of the ban on drugs. However, this does not change the fact that a substantial percentage of the population, especially teenagers are addicted to drugs and face serious problems. I am talking not about the issues of buying cannabis from a shady drug dealer, rather the wider problems faced by the part of the society who deal with or consume drugs. To legalise drugs one has to weigh the pros and cons related to the legalisation of drugs. First, let’s look into the war on drugs and how it has affected the global drug market.

 War on Drugs

In 1961, a United Nation treaty sought to “advance the health and welfare of mankind” by prohibiting the non-medicinal use of drugs. After 50 years of war on drugs led by the US, drugs are still rampant and are more available and widely used than before. With an estimated revenue of $300 billion annually, the trade has played a large role in supporting organised criminals and drug dealers financially.

 A recent report from the Royal Society of Public health, suggested that the war on drugs had failed. Earlier, UK had a more lenient policy towards drug users. NHS used to prescribe heroin to patients who needed it. This changed with the Misuse of Drugs Act 1961, when drugs were classified and its use was criminalised based on their perceived harm. The National Crime Agency predicts that drug trafficking in UK has an estimated cost of £10.7 billion annually. Each year it is estimated that 18-23 tonnes of heroin, 25-30 tonnes of cocaine and around 270 tonnes of cannabis is imported into UK. The effectiveness of prohibition laws must be judged based on outcomes. The increase in trade and consumption of these drugs show that a part of the population still manages to acquire drugs despite stringent drug prohibition laws In. A few countries have already legalised the use of Cannabis based on public opinion. US where the drug war started 8 of the 50 states, have approved the regulation of recreational cannabis. In 2018 Canada will start to regulate and tax cannabis.

 Why legalise drugs?

The problem with drug use prohibition is that it fails to address the real socio-economic factors which leads to people using drugs. The current policy on this prohibition is based on political motives, where a party supports the ban on drugs based on public opinion. Society still maintains an orthodox view on use of drugs despite the fact that the world has undergone many changes in the past century. Recently there has been much criticism and debate about the fact that Prince William suggested we might have a need to legalise drugs.

 Sometimes criminalising drugs might to lead to long-term harmful effects, causing users to be shunned by the society and be excluded from employment and education. If they are arrested for the use of class-A drugs they might be imprisoned, causing them to be exposed to a life of crime and more drug use. This defeats the purpose of the prohibition as it was created to rehabilitate addicts. Furthermore, due to drugs being illegal due to prohibitionist policies, people might resort to sharing needles to inject heroin. This might cause HIV or other infections. Some drugs are ‘cut’ by adding adulterants to increase their volume. This might happen several times at any point before reaching the end user. This type of adulteration has become more common in recent times and has harmful effects on the human body. Hazardous pharmaceutical components such as benzocaine and phenacetin have been detected in drugs such as heroin.

 The current market for drugs is fuelled by the demand for illegal drugs. Due to the risk factors involved in smuggling drugs the dealers can charge higher prices and because of prohibitions, people have no choice but to buy from them. If drug trade were brought under the control of the government, it would shut down this multi-billion dollar illegal trade. Legalising drugs would eliminate the need for middlemen, destroying the entire chain starting from the producers up to the lowest street peddlers.

 Problems with legalising drugs

Legalising drugs isn’t an easy task, it took many decades of work to prohibit drugs and the same work would be required to reverse the process. Furthermore, assuming that all organised crime would dissolve upon legalising drugs is too optimistic. Most probably these criminal groups would turn to other lucrative ventures such as blackmail, robbery and kidnapping.

 Some people who have recovered from drug addiction state that it might prove detrimental to them if drugs were legalised. Their turning point may be due to arrests or police and social pressure. Legalising drugs might lead to a backfire, where addiction to drugs might be trivialised. Some argue that instead of legalising drugs, one might decriminalise it’s use by use of liberal laws to counter addiction, rather than punitive legislation which seeks to punish drug users.

 Of course, I am not advocating for complete legalisation of drugs. It would have to be a closely regulated market where only people in actual need would be able to acquire drugs. It would also help keep tabs on the number of people using drugs and ensure each person gets limited access to drugs thus ensuring they don’t overdose. Legalising drugs also ensures that people know the effects and risks of the drugs they take, since they procure them from government monitored sources.

 Conclusion

There are many countries who have successfully adopted flexible systems to counter drug use. In Portugal, possession of drugs was decriminalised so people caught possessing drugs are subjected to civil rather than criminal sanctions. In Netherlands, the laws allow for possession of Cannabis in small quantities. This has worked out well so far and their consumption does not seem much higher than that of UK.

 The solution to the problems of overuse of drugs after legalisation would be to explore responsible legal regulation of drugs. Currently most political parties are for the drug use ban, as a majority of the public considers their consumption to be unethical. The political parties always support public opinion in order to remain in power. However, if we want to help the people actually affected by drug use, we as voters can sway the party’s opinion if prioritise it at election time. The change of legalising drugs will be a slow and gradual process and mistakes might occur but it is the risk one has to take to bring about change.

[kathyyu205-blog]

Usages of Phenacetin

Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an "A.P.C." or aspirin-phenacetin-caffeine compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent's APC in Australia. However theU.S. Food and Drug Administration ordered the withdrawal of drugs containing phenacetin in November 1983, owing to its carcinogenic and kidney-damaging properties (Federal Register of October 5, 1983 (48 FR 45466)). It was also banned in India.[3] As a result, some branded, previously phenacetin-based preparations continued to be sold, but with the phenacetin replaced by safer alternatives. A popular brand of phenacetin was Roche's Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Coricidin was also reformulated without phenacetin. Paracetamol is a metabolite of phenacetin with similar analgesic and antipyretic effects, but the new formulation has not been found to have phenacetin's carcinogenicity. Phenacetin is now being used as a cutting agent to adulterate cocaine in the UK and Canada, owing to the similar physical features of the two drugs. Due to low cost phenacetin is used for research into the physical and refractive properties of crystals. It is an ideal compound for this type of research.

[alidawu]

High Yield PMK Powder & PMK liquid CAS 28578-16-7

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Hot Selling Organic intermediates:

3- (1-Naphthoyl) Indole CAS 109555-87-5

23076-35-9 Xylazine hydrochloride

2079878-75-2 2-(2-Chlorophenyl)-2-nitrocyclohexanone

288573-56-8 4-(4-fluoroanilino)-1-Piperidinecarboxylate 

125541-22-2 1-N-Boc-4-(Phenylamino)piperidine

79099-07-3 N-(tert-Butoxycarbonyl)-4-piperidone

40064-34-4 4,4-Piperidinediol hydrochloride

443998-65-0 1-N-Boc-4- (Phenylamino) Piperidine

19099-93-5 1-(Benzyloxycarbonyl)-4-piperidinone

PMK ethyl glycidate New PMK Oil CAS 28578-16-7

New pmk glycidate Powder CAS 13605-48-6/52190-28-0

Diethyl(phenylacetyl)malonate BMK oil CAS 20320-59-6

Ethyl 3-Oxo-4-phenylbutanoate BMK oil cas 718-08-1

New BMK Powder CAS 80532-66-7/5449-12-7/25547-51-7/10250-27-8

High Purity Pharmaceutical intermediates(API) :

Pregabalin,CAS 148553-50-8

Phenacetin,CAS 62-44-2

Melanotan II Mt2 CAS 121062-08-6 

Lidocaine,CAS 137-58-6

Lidocaine hydrochloride,CAS 73-78-9

Larocaine/Dimethocaine（DMC）CAS 94-15-5

Dimethocaine Hydrochloride CAS 553-56-9

Boric acid,CAS 11113-50-1

Levamisole (hydrochloride),CAS 16595-80-5

Tetracaine,CAS 94-24-6

Tetracaine hydrochloride CAS 136-47-0

Tetramisole hydrochloride,CAS 5086-74-8

Procaine(hydrochloride),CAS 51-05-8

Procaine,CAS 59-46-1

Benzocaine,CAS 94-09-7

Benzocaine hydrochloride,CAS 23239-88-5

 LOWEST PRICE Ketone intermediates :

2-Bromo-1-phenyl-1-pentanone,CAS 49851-31-2

2-bromo-4-methylpropiophenone CAS 1451-82-7

Pyrrolidine,CAS 123-75-1

Valerophenone,CAS 1009-14-9

HEXANOPHENONE,CAS 942-92-7

4-Methylpropiophenone,CAS 5337-93-9

4-Ethylpropiophenone,CAS 27465-51-6

4′-Chloropropiophenone,CAS 6285-05-8

4′-Methoxypropiophenone,CAS 121-97-1

4-Chloro-p-fluorobutyrophenone,CAS 3874-54-2

 N-Isopropylbenzylamine CAS 102-97-6

P2NP 1-Phenyl-2-nitropropene CAS 705-60-2

2-(2-Chlorophenyl)-2-nitrocyclohexanone CAS 2079878-75-2