#Regorafenib

[global-online-pharmacy]

Regorafenib Stivarga Package insert and Lowest cost

Regorafenib is used to treat colon and rectal cancer (cancer that begins in the large intestine or the rectum) that has spread to other parts of the body in people who have not been treated successfully with certain other medications. It is also used to treat gastrointestinal stromal tumors (GIST; a type of tumor that grows in the stomach, intestine [bowel], or esophagus [tube that connects the throat with the stomach]) in people who were not treated successfully with certain other medications.

How should this medicine be used?

Regorafenib comes as a tablet to take by mouth. It is usually taken with a low-fat meal (containing under 600 calories and less than 30% of calories from fat) once a day for 3 weeks and then skipped for 1 week. This treatment period is called a cycle, and the cycle may be repeated for as long as your doctor recommends. Take regorafenib at the same time every day.

What special precautions should I follow?

Before taking regorafenib, tell your doctor and pharmacist if you are allergic to regorafenib, any other medications, or any of the ingredients in regorafenib tablets. Ask your pharmacist for a list of the ingredients.

What should I do if I forget a dose?

 If you miss a dose of regorafenib, take the missed dose as soon as you remember it on that day. Do not take two doses on the same day to make up for a missed one.

What side effects can this medication cause?

Regorafenib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: tiredness weakness loss of appetite diarrhea swelling, pain, and redness of the lining of your mouth or throat weight loss hoarseness or other change in the sound of your voice.

Above content source:  https://www.911globalmeds.com/info/208-1-Regorafenib-Stivarga-Resihance-Nublexa-Medication-Patient-Information-In-English.pdf

The guaranteed Lowest Cost of STIVARGA / Regorafenib 40 mg @ $15.50 and $102.65 per tablet Online.

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[damngoclam11]

Thuốc Phorego 40mg Regorafenib điều trị ung thư mua ở đâu

Thông tin Thuốc Phorego 40mg

Thành phần hoạt chất chính: Regorafenib 40mg.

Dạng bào chế: dạng viên

Quy cách: hộp 28 viên nén.

Nhà sản xuất thuốc: Phokam Lào.

Chỉ định và Chống chỉ định của thuốc Phorego 40mg 

Chỉ định

Stivarga (regorafenib) có hiệu quả trong điều trị ung thư gan và ung thư đại trực tràng. Nó cũng được sử dụng để điều trị một loại khối u hiếm gặp có thể ảnh hưởng đến dạ dày, thực quản hoặc ruột. Thường được sử dụng sau khi các loại thuốc điều trị ung thư khác đã thất bại.

Chống chỉ định

Quá mẫn cảm với các thành phần có trong thuốc

[pilcare-nce]

Nublexa Tablet - Regorafenib (40mg) - Bayer Zydus - Pilcare - Exporter from India to Guyana

Nublexa Tablet is a Tyrosine kinase inhibitors used in the treatment of cancer of colon and rectum.

[medicineforcare]

Resihance

Resihance

Regorafenib   is a multi-kinase inhibitor used primarily for the treatment of cancer. It is particularly effective in targeting angiogenesis (the formation of new blood vessels), which plays a crucial role in cancer growth and metastasis. Below is a detailed overview of Regorafenib:

Mechanism of Action:

Regorafenib inhibits multiple protein kinases involved in tumor angiogenesis, oncogenesis, and the tumor microenvironment. Specifically, it targets:

VEGFR (Vascular Endothelial Growth Factor Receptor) – involved in blood vessel formation.

PDGFR (Platelet-Derived Growth Factor Receptor) – involved in the growth and survival of cells.

RAF kinases (including BRAF) – involved in cell proliferation and survival.

By blocking these pathways, Regorafenib reduces tumor growth and the spread of cancer.

Indications:

Regorafenib is used in the treatment of several cancers, including:

Colorectal Cancer: It is used in metastatic colorectal cancer (mCRC) that has progressed after standard therapy.

Gastrointestinal Stromal Tumors (GIST): It is prescribed for GIST after imatinib and sunitinib treatment have failed.

Hepatocellular Carcinoma (HCC): For patients with advanced liver cancer who have been previously treated with sorafenib.

Common Side Effects:

Fatigue

Hand-foot skin reaction (redness, swelling, pain in palms and soles)

Diarrhea

Hypertension (high blood pressure)

Nausea and vomiting

Abdominal pain

Decreased appetite

Weight loss

Serious Side Effects:

Liver toxicity: Regorafenib can lead to severe liver damage, including elevated liver enzymes, jaundice, and, in rare cases, liver failure.

Bleeding: Regorafenib can increase the risk of severe bleeding, especially in patients with cancer that has spread to the liver.

Cardiovascular complications: It can lead to high blood pressure and may increase the risk of heart attack or stroke.

Gastrointestinal perforation: A rare but potentially life-threatening complication.

Monitoring and Precautions:

Liver function should be monitored regularly because of the risk of liver toxicity.

Blood pressure should be checked frequently to detect any early signs of hypertension.

Skin reactions should be monitored closely, as they can affect the patient's quality of life.

Kidney function should also be assessed periodically, especially in patients at risk of kidney damage.

Pharmacokinetics:

Absorption: Regorafenib is well absorbed after oral administration but should be taken with a low-fat meal to ensure proper absorption.

Metabolism: The drug is metabolized in the liver primarily through CYP3A4, and its active metabolites also play a role in its efficacy.

Excretion: Regorafenib and its metabolites are excreted primarily through feces, with a small portion eliminated through urine.

[regenhealthsolutions]

Combination therapy significantly improves outcomes for patients with metastatic colorectal cancer

Combining immune-targeted therapy with chemotherapy improves both progression-free survival and overall survival when compared to those who received regorafenib alone A study(Link is external) (Link opens in new window) led by UCLA Health Jonsson Comprehensive Cancer Center(Link opens in new window) researchers found that using a combination of experimental immunotherapy drugs with chemotherapy…

[drkamath]

What is GIST(Gastrointestinal Stromal Tumor) in Bangalore by Dr. Anil Kamath

Have you ever wondered about those rare conditions that can lurk silently within our bodies? One such condition is the Gastrointestinal Stromal Tumor, commonly known as GIST. This article dives deep into understanding GIST, its diagnosis, treatment options, and why Dr. Anil Kamath in Bangalore is a leading figure in treating this condition.

Understanding GIST

What is a Gastrointestinal Stromal Tumor?

GISTs are a type of tumor that occurs in the digestive tract. They most commonly arise in the stomach or small intestine but can develop anywhere along the gastrointestinal tract. Unlike other more common cancers, GISTs originate from specific cells in the digestive system called interstitial cells of Cajal.

How common are GISTs?

Though GISTs are relatively rare, they are the most common type of mesenchymal tumors found in the gastrointestinal tract. The incidence rate is about 10–20 per million people annually. Despite their rarity, understanding and early detection are crucial for effective treatment.

Symptoms of GIST

GISTs might not cause symptoms initially, which makes them tricky to detect early. However, as they grow, they can cause a range of symptoms such as:

Abdominal pain or discomfort

Gastrointestinal bleeding

Nausea and vomiting

Loss of appetite

Unintended weight loss

Fatigue

Causes and Risk Factors

Genetic Factors

Most GISTs occur sporadically, but a small percentage can be inherited. Mutations in the KIT or PDGFRA genes are typically responsible for the development of these tumors.

Age and Lifestyle Factors

GISTs can occur at any age but are more common in people over 50. Lifestyle factors, such as smoking and a diet high in processed foods, might also contribute to the risk.

Other Risk Factors

Certain hereditary syndromes and pre-existing health conditions can increase the risk of developing GIST. Regular medical check-ups are essential for early detection, especially if you fall into a high-risk category.

Diagnosis of GIST

Initial Medical Consultation

If you experience any symptoms associated with GIST, the first step is to consult a healthcare provider. They will take a detailed medical history and perform a physical examination.

Diagnostic Tests and Imaging

Imaging tests such as CT scans, MRI, and PET scans are vital for detecting GISTs. These tests help determine the tumor’s size, location, and whether it has spread to other parts of the body.

Biopsy Procedures

A biopsy, where a small tissue sample is taken from the tumor, is essential for confirming the diagnosis. This sample is then examined under a microscope to detect cancerous cells.

Stages of GIST

Early-stage GIST

At this stage, the tumor is confined to its origin and has not spread. Treatment at this stage is often more successful.

Advanced-stage GIST

Here, the tumor has grown larger and may have started to invade surrounding tissues. More intensive treatment is usually required.

Metastatic GIST

This is the most severe stage, where the tumor has spread to other parts of the body. Treatment focuses on managing symptoms and slowing the tumor’s progression.

Treatment Options for GIST

Surgical Interventions

Surgery is often the primary treatment for GIST, especially if the tumor is localized. The goal is to remove the tumor completely.

Medication and Chemotherapy

While traditional chemotherapy is not very effective for GIST, certain medications can help manage the condition. Imatinib (Gleevec) is commonly used to treat GIST by targeting specific cancer cells.

Targeted Therapy

Targeted therapy focuses on specific molecules involved in cancer growth. Drugs like sunitinib (Sutent) and regorafenib (Stivarga) are used when GIST does not respond to initial treatments.

Radiation Therapy

Although not commonly used for GIST, radiation therapy can help control symptoms, especially in metastatic cases.

Why Choose Dr. Anil Kamath for GIST Treatment?

Dr. Kamath’s Expertise and Experience

Dr. Anil Kamath is renowned for his expertise in treating GIST. With extensive experience and a compassionate approach, he has helped many patients manage and overcome this condition.

Success Stories and Patient Testimonials

Many patients treated by Dr. Kamath have shared their success stories, highlighting his skill and dedication. These testimonials reflect the high level of care and positive outcomes experienced under his treatment.

Advanced Technology and Facilities

Dr. Kamath utilizes the latest technology and facilities to provide cutting-edge treatment for GIST. His clinic in Bangalore is equipped with advanced diagnostic and therapeutic tools, ensuring patients receive the best possible care.

Living with GIST

Managing Side Effects

Treatment for GIST can have side effects, but these can be managed with the right strategies. Regular follow-ups and a supportive care team are crucial.

Diet and Lifestyle Changes

Maintaining a healthy diet and active lifestyle can improve overall well-being and help manage symptoms. Dr. Kamath often provides personalized dietary and lifestyle advice to his patients.

Emotional and Psychological Support

Dealing with a cancer diagnosis can be overwhelming. Emotional and psychological support, whether through counseling or support groups, is essential for patients and their families.

Preventive Measures and Early Detection

Routine Check-ups and Screenings

Regular medical check-ups and screenings can lead to early detection of GIST, which significantly improves the chances of successful treatment.

Awareness and Education

Being aware of the symptoms and risk factors associated with GIST can lead to earlier diagnosis and treatment. Educational initiatives can help spread this vital information.

Conclusion

Understanding GIST and the importance of early detection cannot be overstated. With advancements in treatment and the expertise of specialists like Dr. Anil Kamath, patients have a better chance at managing and overcoming this condition. Don’t wait for symptoms to escalate — proactive healthcare can make all the difference.

[b2bbusiness]

Advancements and Market Trends in Colorectal Cancer Treatment

Colorectal cancer, a type of cancer that starts in the colon or rectum, is one of the most prevalent and deadly cancers worldwide. Despite significant progress in early detection and treatment options, colorectal cancer remains a significant health challenge, driving ongoing research, innovation, and investment in the market. This article explores the current landscape of the colorectal cancer market, including recent advancements, emerging trends, and future prospects.

Market Overview: The global colorectal cancer market has experienced steady growth in recent years, driven by factors such as the rising incidence of colorectal cancer, an aging population, and advancements in treatment options. According to the American Cancer Society, colorectal cancer is the third most common cancer diagnosed in both men and women in the United States, highlighting the significant market potential for colorectal cancer treatments.

Key Players: Several pharmaceutical companies and biotech firms are actively involved in the development and commercialization of colorectal cancer therapies. Key players in the market include:

Roche Holding AG: Roche's blockbuster drug, Avastin (bevacizumab), is widely used in the treatment of colorectal cancer, particularly in combination with chemotherapy.

Merck & Co., Inc.: Merck's immunotherapy drug, Keytruda (pembrolizumab), has shown promising results in treating advanced colorectal cancer with specific genetic mutations.

Bayer AG: Bayer's Stivarga (regorafenib) is approved for the treatment of metastatic colorectal cancer that has progressed after standard therapies.

Bristol Myers Squibb: Bristol Myers Squibb's Opdivo (nivolumab) is another immunotherapy option being explored for the treatment of colorectal cancer.

Pfizer Inc.: Pfizer's Xalkori (crizotinib) and Lorbrena (lorlatinib) are among the targeted therapies being investigated for colorectal cancer treatment.

Recent Advancements: The colorectal cancer market has witnessed several significant advancements in recent years, driving improvements in patient outcomes and treatment efficacy. These advancements include:

Immunotherapy: Immunotherapy has emerged as a promising approach for colorectal cancer treatment, particularly in patients with specific genetic mutations or microsatellite instability-high (MSI-H) tumors. Drugs like Keytruda and Opdivo harness the body's immune system to target and destroy cancer cells.

Targeted Therapies: Targeted therapies, which specifically target cancer cells based on their genetic makeup, have shown efficacy in colorectal cancer treatment. Drugs like Stivarga and Xalkori inhibit specific molecular pathways involved in cancer growth and progression.

Biomarker Testing: Advances in biomarker testing have enabled oncologists to personalize treatment approaches based on the unique genetic profile of each patient's tumor. Biomarker testing helps identify patients who are most likely to benefit from targeted therapies or immunotherapy.

Minimally Invasive Surgery: Minimally invasive surgical techniques, such as laparoscopic and robotic-assisted surgeries, have become standard in the treatment of colorectal cancer. These techniques offer faster recovery times, reduced postoperative pain, and improved cosmetic outcomes compared to traditional open surgery.

Emerging Trends: Several emerging trends are shaping the future of the colorectal cancer market:

Combination Therapies: Researchers are exploring the potential benefits of combining immunotherapy with other treatment modalities, such as chemotherapy, targeted therapy, and radiation therapy, to enhance treatment efficacy and overcome resistance mechanisms.

Liquid Biopsies: Liquid biopsy techniques, which involve analyzing tumor-derived genetic material in blood samples, hold promise for early detection, monitoring treatment response, and detecting the emergence of resistance mutations in colorectal cancer patients.

Artificial Intelligence (AI) and Machine Learning: AI and machine learning algorithms are being increasingly utilized to analyze complex genomic and imaging data, predict treatment outcomes, and identify novel therapeutic targets in colorectal cancer.

Patient-Centric Care: There is a growing emphasis on patient-centered care in the management of colorectal cancer, with healthcare providers focusing on improving patient education, support services, and survivorship care to enhance overall quality of life.

For more insights into the Colorectal Cancer market forecast, download a free report sample

[aetospharma]

Regorafenib Tablets : Choose Aetos Pharma for Quality

Aetos Pharma is your trusted provider for superior Regorafenib tablets in Ahmedabad, Gujarat. Being a leading pharmaceutical company, we place great emphasis on making crucial medications easily and affordably available. Believe our team for genuine Regorafenib tablets to meet your needs.

Call us today : +91-7946020065 Visit Our Website : https://www.aetospharma.com/product-tag/regorafenib-tablet-40mg-supplier/

[damngoclam11]

Thuốc Phorego 40mg Regorafenib điều trị ung thư mua ở đâu

Thuốc Phorego 40mg Regorafenib là một loại thuốc dùng để điều trị ung thư ruột kết không lan tỏa hoặc lan tỏa không đáp ứng với các phương pháp điều trị trước đó. Nó cũng được chỉ định để điều trị ung thư gan giai đoạn cuối đã tiến triển bằng các phương pháp điều trị khác. Phorego Regorafenib hoạt động bằng cách ngăn chặn sự phát triển của các mạch máu mới của khối u  do đó làm chấm sự phát triển của khối u. Tuy nhiên, giống như bất kỳ loại thuốc nào khác, thuốc Phorego 40mg cũng có tác dụng phụ và chỉ nên sử dụng theo chỉ định của bác sĩ chuyên khoa. Bạn nên liên hệ với bác sĩ để biết thêm thông tin về việc sử dụng thuốc Phorego 40mg.

Thông tin Thuốc Phorego 40mg

Thành phần hoạt chất chính: Regorafenib 40mg.

Dạng bào chế: dạng viên

Quy cách: hộp 28 viên nén.

Nhà sản xuất thuốc: Phokam Lào.

https://thuockedon24h.com/thuoc-phorego-40mg-regorafenib-dieu-tri-ung-thu-mua-o-dau/

[drchintamanigodbole]

Dr. Chintamani Godbole: Leading Colorectal Cancer Treatment in India

Dr. Chitamani Godbole's Approach to Colorectal Cancer Treatment

Colorectal cancer, also known as bowel cancer, is a type of cancer that begins in the colon or rectum. It typically starts as a growth of tissue called a polyp, which can be noncancerous (benign) or cancerous (malignant). Over time, cancerous polyps can grow and invade surrounding tissues or spread (metastasize) to other parts of the body.

- Surgery: Dr. Godbole specializes in various surgical procedures tailored to the size and location of colorectal tumors, including polypectomy, colectomy, and proctectomy.

- Chemotherapy: Utilizing advanced chemotherapy drugs, Dr. Godbole employs neoadjuvant or adjuvant chemotherapy strategies to shrink tumors before surgery or eliminate residual cancer cells post-surgery.

- Radiation Therapy: Dr. Godbole offers radiation therapy options, either as a standalone treatment or in combination with chemotherapy, to effectively target colorectal tumors and enhance treatment outcomes.

- Targeted Therapy: With expertise in targeted therapy drugs such as cetuximab, panitumumab, bevacizumab, and regorafenib, Dr. Godbole provides personalized treatment plans for patients with advanced colorectal cancer.

- Immunotherapy: While focusing on conventional treatments, Dr Godbole also explores immunotherapy options, particularly for patients with MSI-High tumours, to bolster the body's immune response against colorectal cancer cells.

- Clinical Trials: Dr. Godbole offers access to cutting-edge clinical trials, allowing patients to explore experimental treatments and contribute to the advancement of colorectal cancer care.

For personalized colorectal cancer treatment in India Contact at 84518 65944 or  Book An Appointment with Dr. Chintamani Godbole at Gadre Hospital.

[mollyleonaa]

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[ethena11]

Empowering cancer treatment with precision. This breakthrough medication, containing Regorafenib, inhibits tumor growth and enhances overall survival. In a convenient pack of 28 tablets, Regonat offers hope and resilience in the battle against advanced cancers. For a cost-effective option on Regonat Regorafenib 40 mg Tablet, reach out to Drugssquare Pharmacy.

[tumimmtxpapers]

Regorafenib induces damage-associated molecular patterns, cancer cell death and immune modulatory effects in a murine triple negative breast cancer model

Damage associated molecular patterns (DAMPs), including calreticulin (CRT) exposure, high-mobility group box 1 protein (HMGB1) elevation, and ATP release, characterize immunogenic cell death (ICD) and may play a role in cancer immunotherapy. Triple negative breast cancer (TNBC) is an immunogenic subtype of breast cancer with higher lymphocyte infiltration. Here, we found that regorafenib, a multi-target angiokinase inhibitor previously known to suppress STAT3 signaling, induced DAMPs and cell... http://dlvr.it/SpMZG1

[medicineforcare]

Resihance

Resihance

Regorafenib   is a multi-kinase inhibitor used primarily for the treatment of cancer. It is particularly effective in targeting angiogenesis (the formation of new blood vessels), which plays a crucial role in cancer growth and metastasis. Below is a detailed overview of Regorafenib:

Mechanism of Action:

Regorafenib inhibits multiple protein kinases involved in tumor angiogenesis, oncogenesis, and the tumor microenvironment. Specifically, it targets:

VEGFR (Vascular Endothelial Growth Factor Receptor) – involved in blood vessel formation.

PDGFR (Platelet-Derived Growth Factor Receptor) – involved in the growth and survival of cells.

RAF kinases (including BRAF) – involved in cell proliferation and survival.

By blocking these pathways, Regorafenib reduces tumor growth and the spread of cancer.

Indications:

Regorafenib is used in the treatment of several cancers, including:

Colorectal Cancer: It is used in metastatic colorectal cancer (mCRC) that has progressed after standard therapy.

Gastrointestinal Stromal Tumors (GIST): It is prescribed for GIST after imatinib and sunitinib treatment have failed.

Hepatocellular Carcinoma (HCC): For patients with advanced liver cancer who have been previously treated with sorafenib.

Common Side Effects:

Fatigue

Hand-foot skin reaction (redness, swelling, pain in palms and soles)

Diarrhea

Hypertension (high blood pressure)

Nausea and vomiting

Abdominal pain

Decreased appetite

Weight loss

Serious Side Effects:

Liver toxicity: Regorafenib can lead to severe liver damage, including elevated liver enzymes, jaundice, and, in rare cases, liver failure.

Bleeding: Regorafenib can increase the risk of severe bleeding, especially in patients with cancer that has spread to the liver.

Cardiovascular complications: It can lead to high blood pressure and may increase the risk of heart attack or stroke.

Gastrointestinal perforation: A rare but potentially life-threatening complication.

Monitoring and Precautions:

Liver function should be monitored regularly because of the risk of liver toxicity.

Blood pressure should be checked frequently to detect any early signs of hypertension.

Skin reactions should be monitored closely, as they can affect the patient's quality of life.

Kidney function should also be assessed periodically, especially in patients at risk of kidney damage.

Pharmacokinetics:

Absorption: Regorafenib is well absorbed after oral administration but should be taken with a low-fat meal to ensure proper absorption.

Metabolism: The drug is metabolized in the liver primarily through CYP3A4, and its active metabolites also play a role in its efficacy.

Excretion: Regorafenib and its metabolites are excreted primarily through feces, with a small portion eliminated through urine.

[reportsneww]

Hepatocellular Carcinoma Market demand will reach a value of US$ 41.57 Billion by the year 2030 at a CAGR of 11.5% | Growth Plus Reports

Newark, New Castle, USA – Growth Plus Reports’ most recent study examines the Global Hepatocellular Carcinoma Market’s production, prospective uses, demand, key companies, and SWOT analysis.

You may get insights into the TOC, and Statistics for essential facts, information, trends, and competitive landscape information.

Download Free Sample Report Now @ https://www.growthplusreports.com/inquiry/request-sample/hepatocellular-carcinoma-market/8027

The following are the leading companies in the Global Hepatocellular Carcinoma market:

Bayer AG

Bristol-Myers Squibb

Genentech Inc.

Eisai Inc.

Merch & Co. Inc.

Eli Lilly & Company

Dainippon Sumitomo Pharma

Growth Plus Reports studies the key trends in each category and sub-segment of the Hepatocellular Carcinoma market, along with Global and regional projections from 2023 to 2031. Our research splits the market into product type and application segments.

SEGMENTATION

GLOBAL HEPATOCELLULAR CARCINOMA MARKET – ANALYSIS & FORECAST, BY MARKETED DRUG

Sorafenib (Nexavar)

Nivolumab (Opdivo)

Bevacizumab (Avastin)

Regorafenib (Stivarga)

Lenvatinib Mesylate (Lenvima)

Pembrolizumab (Keytruda)

Atezolizumab (Tecentriq)

 Cabozantinib (Cabometyx)

Ramucirumab (Cyramza)

 Miriplatin (Miripla)

For More Information or Query or Customization visit: https://www.growthplusreports.com/inquiry/customization/hepatocellular-carcinoma-market/8027

Companies may utilize Hepatocellular Carcinoma market report to get insights on market variables and any restraints that may affect the manufacturing of their product. Companies that are expanding abroad require thorough Global market research that includes real market data to assist with their marketing strategy. This Global market Hepatocellular Carcinoma industry study analyzes important market dynamics and provides in-depth information and statistics to help companies flourish. This research report on the Hepatocellular Carcinoma market takes advantage of advanced and professional approaches such as SWOT analysis and GRG Health’s unique GrowthMIX strategy.

This report is useful in addressing various essential issues for market participants, while also supporting them in making investments and leveraging the market opportunities.

Hepatocellular Carcinoma Market TOC: https://www.growthplusreports.com/report/toc/hepatocellular-carcinoma-market/8027

Market segment by Region/Country including: –

-North America (United States, Canada and Mexico) -Europe (Germany, UK, France, Italy, Russia and Spain etc.) -Asia-Pacific (China, Japan, Korea, India, Australia and Southeast Asia etc.) -South America (Brazil, Argentina and Colombia etc.) -Middle East and Africa (South Africa, UAE and Saudi Arabia etc.)

QUICK BUY: https://www.growthplusreports.com/checkout-8027

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