#Tamoxifen Side Effects

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Craig Jordan

Pharmacologist whose research into tamoxifen helped many women with breast cancer to live longer

In the 1970s only 40% of women diagnosed with breast cancer could expect to survive for 10 years or more. Today that figure is over 75%. Screening and early diagnosis have played a part, but one of the key reasons for the improvement is the drug tamoxifen, which massively reduces the risk of cancer recurring after surgery.

The British-American pharmacologist Craig Jordan, who has died aged 76, was the first to show that tamoxifen could stop tumours growing by blocking the female hormone oestrogen from locking on to cells in the breast at specific sites called oestrogen receptors.

Breast cancer is the commonest cancer in women across the world and 80% of women with the disease have receptors that make them sensitive to oestrogen, which can stimulate cells in the breast to reproduce uncontrollably and form tumours.

Jordan’s lifelong study of tamoxifen led to the discovery of a range of other effective treatments for breast cancer that either blocked oestrogen receptors or reduced the amount of the hormone the body produces. His studies have also improved women’s health by shedding light on other conditions including endometrial cancer, osteoporosis and menopausal symptoms.

He made his discoveries in the face of huge scepticism from the medical community. He was not a medical doctor but a laboratory scientist who conducted his research on rats and mice. Tamoxifen does not kill cancer cells, it simply stops them from growing. The received wisdom in the 70s when he began his work was that the only way to deal with cancer was to cut it out, or blast it with radiation or powerful chemicals to destroy every trace of the tumour. Such treatments, though they can be effective, are distressing for patients and have many side effects.

“There was an obsession with the idea that that combination chemotherapies were going to cure all cancers,” Jordan told the website Oncology Central in 2019. “It felt like we were trying to swim upstream as we were saying no, target the [o]estrogen receptor and give tamoxifen forever and people will stay alive.”

It took decades before the evidence for tamoxifen’s effectiveness became undeniable. A number of clinical research groups, encouraged by Jordan’s laboratory results, had tested tamoxifen in patients, but the results, though encouraging, were too marginal to change practice.

In 1998 the Early Breast Cancer Triallists Collaborative Group, based in Oxford, combined the data from studies of 37,000 women to show that those with oestrogen-sensitive tumours who took tamoxifen for five years after surgery experienced a 47% reduction in the risk of the cancer returning and a 26% reduction in the risk of dying within 10 years.

Tamoxifen and other selective oestrogen receptor modulators are now part of the standard treatment for women who have had surgery for oestrogen-sensitive breast cancers.

Jordan’s mother, Cynthia Mottram, was a GI bride who met his father, Virgil Johnson, when he was in service as a soldier with the US army in Britain during the second world war. They returned to New Braunfels in Texas, where Jordan was born, but the marriage broke down and she brought her son back to her home in Cheshire when he was a toddler.

He attended Moseley Hall grammar school in Cheadle, where he took to chemistry with such enthusiasm that his mother let him set up a laboratory at home (leading to the kinds of near-disaster that punctuate the early lives of many successful scientists). After his mother remarried, Craig was adopted by his stepfather, Geoffrey Jordan, and took his name.

At first his ambition did not reach beyond working as a technician at the nearby ICI laboratories, but he successfully obtained a place at the University of Leeds to study pharmacology. Taking a summer job with ICI, he met the endocrinologist Arthur Walpole, who had been part of the team that developed tamoxifen, then known as ICI 46,474.

It was supposed to be a contraceptive, but early trials led to more pregnancies, rather than fewer. During his PhD at Leeds, Jordan developed strong links with the ICI scientists, who funded the early stages of his work on oestrogen receptors.

In 1972 Jordan went to the Worcester Foundation for Experimental Biology in Massachusetts. The lab focused on contraception, but as ICI 46,474 had failed as a contraceptive Jordan began to examine its effects on breast cancer in rats. Meanwhile, in 1973, ICI had given the drug a name, tamoxifen, and launched it as a not particularly effective treatment for late-stage breast cancer.

The following year Jordan returned to Leeds as a lecturer, where he continued to collaborate with ICI. His key discoveries in this period were that given over a period of years, tamoxifen could be used to prevent cancer coming back after surgery; and that it could prevent cancer developing in women whose biology put them at particularly high risk. He also discovered a very effective breakdown product of tamoxifen that went on to form the basis of other drugs that prevent postmenopausal women from losing bone density.

In 1980 he moved permanently to the US, where he held senior positions at a succession of leading research universities, setting up a “tamoxifen team” at each, before finally settling in 2014 as a professor and chair of cancer research at the University of Texas MD Anderson Cancer Center in Houston. His further discoveries included a small increased risk of endometrial cancer with tamoxifen, so that doctors now screen their patients before prescribing the drug.

For much of his life, Jordan had an unusual parallel career as an adviser on biological and chemical weapons – and illicit drug use – to the British and US armies.

His family had a strong military heritage and he had joined the Officers’ Training Corps while a student at Leeds, combining his PhD research with stints with the army in Germany during the cold war. He went on to be recruited into the intelligence corps with the rank of captain, and subsequently became a member of the SAS reserve. He was an avid collector of antique weapons, and described himself as an “outstanding shot”.

He received many honours in the course of his career, and was appointed CMG in the Queen’s birthday honours in 2019 for services to women’s health. In turn he funded prizes, scholarships and special lectures at the universities of Leeds and Oxford, conscious of the debt he owed to British society for his early education and research opportunities. He was open about his diagnosis with kidney cancer in 2018 and continued working until shortly before his death.

Craig Jordan was married three times, each marriage ending in divorce. He is survived by Alexandra and Helen, his daughters from his first marriage, to Marion Williams, and five grandchildren.

🔔 Virgil Craig Jordan, pharmacologist, born 25 July 1947; died 9 June 2024

Daily inspiration. Discover more photos at Just for Books…?

[some1s-sista]

Just days of Dr appointments this week. But saw the medical oncologist and I’m not going on Tamoxifen or Ibrance (yay! Because I didn’t like their list of side effects) but instead were trying Arimidex (worst side effects hot flashes, joint pain and osteoporosis) and he’ll see how I’m doing in a month. Because it causes osteoporosis, I had to have a bone density test today. Then I went to CVS to pick up the Rx and there was no charge for it! Could I have finally picked a decent health plan??? We’ll see.

Also had my mediport flushed and found out he doesn’t want it removed for a year yet, just in case we need it again. I said “we’ll that’s not thinking positively!”

Monday I see the surgical oncologist and we’ll set up the new mammograms and such. So I’m done with active treatments but I still have quite a few appointments through February.

Also I’ve lost 10 lbs the past couple weeks but there’s no one to yell at me now. Just haven’t felt like eating much. And the brain fog! Whoo baby. I’m lucky I can remember my own name, so yeah, still feeling the effects of radiation.

[acronlaboratories1]

Testosterone Propionate post-cycle therapy guidelines

After completing a cycle of Testosterone Propionate, it’s crucial to implement Post-Cycle Therapy (PCT) to help the body recover its natural testosterone production. Since anabolic steroids suppress natural hormone levels, a proper PCT helps to restore hormonal balance, prevent muscle loss, and reduce side effects like fatigue or mood swings.

Typically, PCT starts about 3-4 days after the last Testosterone Propionate injection. Common PCT medications include Clomid (Clomiphene) and Nolvadex (Tamoxifen), which stimulate natural testosterone production. Dosages are usually Clomid at 50mg/day and Nolvadex at 20mg/day for 4-6 weeks.

Additionally, using HCG (Human Chorionic Gonadotropin) during the cycle can help prevent severe testosterone suppression. A healthy diet, regular exercise, and sufficient sleep are also essential during PCT for optimal recovery.

[medicineforcare]

Generic Arimidex

Arimidex is a brand name for anastrozole, a medication primarily used to treat breast cancer in postmenopausal women. It is a type of drug called an aromatase inhibitor, which works by reducing estrogen levels in the body. Since many breast cancers are estrogen-sensitive, lowering estrogen can help slow or stop the growth of these cancers. Here is a detailed breakdown of the generic drug anastrozole (Arimidex):

Mechanism of Action

Anastrozole works by inhibiting the enzyme aromatase, which is responsible for converting androgens (male hormones) into estrogens (female hormones) in the body. Since many breast cancers grow in response to estrogen, reducing the amount of estrogen in the body can help shrink or slow the growth of the tumor.

Uses

Breast Cancer Treatment: Mainly used for treating hormone receptor-positive breast cancer in postmenopausal women.

Prevention of Cancer Recurrence: Helps reduce the risk of breast cancer recurrence after surgery.

Occasional Off-Label Uses: May sometimes be prescribed for ovarian cancer or as part of treatment for infertility in some cases.

Side Effects

Common side effects of anastrozole include:

Hot flashes

Joint pain (arthralgia)

Osteoporosis: As estrogen helps maintain bone density, its reduction can increase the risk of bone thinning and fractures.

Fatigue

Nausea

Mood changes or depression

Increased cholesterol levels

Less common but serious side effects:

Heart disease or cardiovascular issues: Some studies have shown an increased risk of heart disease, particularly in women with pre-existing risk factors.

Liver function issues: In rare cases, anastrozole can cause liver enzyme elevations.

Severe allergic reactions: Rash, hives, and swelling (rare).

Contraindications

Pre-menopausal women: Not recommended for women who have not yet gone through menopause.

Pregnancy and Breastfeeding: Anastrozole can harm a developing fetus and is not recommended during pregnancy or while breastfeeding.

Severe liver or kidney disease: Requires caution in patients with significant liver or kidney impairment.

Drug Interactions

Tamoxifen: Anastrozole should not be used with tamoxifen, another breast cancer drug, as tamoxifen can reduce the effectiveness of anastrozole.

Estrogen-containing products: Hormone replacement therapy (HRT) or other estrogen supplements can counteract anastrozole’s effect.

Monitoring

Bone Density Tests: Regular monitoring for osteoporosis and bone health may be needed, and supplements like calcium and vitamin D may be recommended.

Cholesterol Levels: As anastrozole can elevate cholesterol, periodic lipid panel checks may be advised.

Cost and Availability

Generic Availability: Generic anastrozole is widely available and generally less expensive than the brand-name Arimidex.

Insurance Coverage: Usually covered under prescription insurance, though out-of-pocket costs will vary depending on the insurance plan and dosage.

[steroidmart]

Nolvadex in the UK: Dosage, Side Effects, and Where to Buy

Nolvadex, also known by its generic name Tamoxifen, is a medication widely used in the UK for its role in treating breast cancer and for its effectiveness in post-cycle therapy (PCT) among steroid users. This article provides a detailed overview of Nolvadex, including its recommended dosages, potential side effects, and where you can buy it in the UK.

What is Nolvadex?

Nolvadex is a selective estrogen receptor modulator (SERM). It works by binding to estrogen receptors, blocking the hormone estrogen from promoting the growth of cancer cells. This mechanism makes Nolvadex particularly effective in treating hormone receptor-positive breast cancer, where cancer cells rely on estrogen to grow. Beyond its primary medical use, Nolvadex has found a significant following in the fitness community, where it is used to counteract the side effects of anabolic steroids and support hormonal recovery during post-cycle therapy.

Dosage of Nolvadex in the UK

The dosage of Nolvadex can vary depending on the purpose of its use. Here’s a breakdown of typical dosages:

For Breast Cancer Treatment:

Standard Dosage: For treating breast cancer, Nolvadex is generally prescribed at 20 to 40 mg per day. This dosage can be taken in one or two doses throughout the day, with or without food. For preventive measures in high-risk patients, the dosage is typically 20 mg daily, often taken for five years. The exact dosage and duration depend on individual health factors and treatment goals.

For Post-Cycle Therapy (PCT):

Typical Dosage: In the context of post-cycle therapy, Nolvadex is used to help restore natural testosterone production and prevent estrogen-related side effects after a steroid cycle. A common dosage for PCT is 20-40 mg per day, usually taken for 4 to 6 weeks. This helps to mitigate side effects like gynecomastia (breast tissue development in men) and support the body’s recovery process.

It’s crucial to follow the dosage instructions provided by a healthcare professional or a knowledgeable coach to ensure safety and effectiveness. Adjusting the dosage without professional advice can lead to ineffective treatment or increased risk of side effects.

Potential Side Effects of Nolvadex

While Nolvadex is generally well-tolerated, it can cause side effects. Common side effects include:

Hot Flashes: Users may experience sudden feelings of warmth, which can be accompanied by sweating.

Nausea: Some individuals may feel nauseous or have stomach discomfort.

Fatigue: Tiredness or weakness is a common side effect, particularly when starting the medication.

Menstrual Changes: Women might notice alterations in their menstrual cycle while on Nolvadex.

Leg Cramps: Muscle cramps or discomfort in the legs can occur.

More severe side effects, though rare, can include blood clots, stroke, and endometrial cancer. If you experience severe symptoms such as chest pain, sudden shortness of breath, vision changes, or signs of a stroke, it is essential to seek medical attention immediately.

Where to Buy Nolvadex in the UK

Nolvadex is available through various channels in the UK. Here’s where you can purchase it:

Pharmacies: The most reliable and secure way to buy Nolvadex is through a licensed pharmacy. A prescription from a healthcare provider is required to purchase Nolvadex legally. Pharmacies ensure that you receive a genuine product that meets safety standards.

Online Stores: Nolvadex can also be purchased from reputable online pharmacies. When buying online, it’s important to select a trusted seller to avoid counterfeit products. Look for websites with positive reviews and a history of reliable service. Ensure the website requires a prescription, which indicates a more legitimate operation.

Specialist Clinics: Some clinics specializing in hormone therapy or sports medicine offer Nolvadex. These clinics can provide tailored advice and support regarding its use, especially in the context of PCT.

[ganitsoni]

Advanced Treatments for Breast Cancer: What You Need to Know

Breast cancer treatment has evolved significantly, offering a range of advanced options designed to target the disease more effectively and with fewer side effects. If you or someone you know is facing a breast cancer diagnosis, understanding these treatments can help make informed decisions. Here’s a comprehensive guide to the latest advanced treatments available.

1. Targeted Therapy

Targeted therapy is a sophisticated treatment that focuses on specific molecules involved in cancer growth. Unlike traditional chemotherapy, which affects all rapidly dividing cells, targeted therapy zeroes in on cancer cells, minimizing damage to healthy cells. This approach can reduce side effects and enhance treatment effectiveness.

HER2 Inhibitors: For cancers that overexpress the HER2 protein, drugs like trastuzumab (Herceptin) and pertuzumab (Perjeta) are used. These drugs block the HER2 growth factor, slowing or stopping cancer progression.

CDK4/6 Inhibitors: Drugs such as palbociclib (Ibrance) target proteins that help cancer cells divide. This treatment is especially useful for hormone receptor-positive breast cancers, helping to control tumor growth.

2. Immunotherapy

Immunotherapy helps the body's immune system fight cancer by boosting or modifying its natural ability to recognize and destroy cancer cells. This approach has shown promise in treating various cancers, including breast cancer.

Checkpoint Inhibitors: These drugs block proteins that prevent immune cells from attacking cancer cells. Pembrolizumab (Keytruda) is one such drug that has been used to treat certain types of breast cancer.

Cancer Vaccines: Though still largely experimental, cancer vaccines aim to stimulate the immune system to target specific cancer cells. Research continues to advance these therapies, making them a potential future treatment option.

3. Hormone (Endocrine) Therapy

Hormone therapy is used for breast cancers that are hormone receptor-positive, meaning they grow in response to hormones like estrogen or progesterone. This treatment works by blocking the effects of these hormones or lowering their levels in the body.

Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a well-known SERM that binds to estrogen receptors, preventing estrogen from fueling cancer growth.

Aromatase Inhibitors: Drugs like anastrozole (Arimidex) and letrozole (Femara) lower estrogen levels by inhibiting the aromatase enzyme, which is responsible for estrogen production in postmenopausal women.

4. Chemotherapy

Chemotherapy remains an important option for treating breast cancer, especially when other treatments are not enough. It uses powerful drugs to kill rapidly dividing cancer cells. Modern approaches include:

Neoadjuvant Chemotherapy: Administered before surgery, this treatment shrinks tumors, making them easier to remove.

Adjuvant Chemotherapy: Given after surgery, this treatment aims to eliminate any remaining cancer cells and reduce the risk of recurrence.

5. Personalized Medicine

Personalized medicine tailors treatment to the individual characteristics of each patient’s cancer. This approach involves analyzing genetic mutations and markers specific to the cancer to select the most effective therapies.

Genomic Testing: Helps doctors understand the genetic changes driving cancer, allowing them to choose targeted treatments that are more likely to work for the specific type of cancer.

6. Radiation Therapy

Radiation therapy uses high-energy rays to target and kill cancer cells. It is often used after surgery to remove any remaining cancer cells in the breast, chest wall, or underarm area. New techniques such as intensity-modulated radiation therapy (IMRT) offer more precise targeting, reducing side effects and improving treatment outcomes.

7. Surgery

Surgical options for breast cancer have also advanced, offering less invasive choices and better recovery outcomes:

Lumpectomy: This procedure involves removing the tumor and a small margin of surrounding tissue. It is often followed by radiation therapy to ensure all cancer cells are eliminated.

Mastectomy: Involves removing one or both breasts. Advances in reconstructive surgery can help restore appearance and improve recovery.

8. Clinical Trials

Participating in clinical trials can provide access to the latest treatments and contribute to medical research. Clinical trials test new therapies and approaches, which may offer additional options not yet available outside of a research setting. Discussing clinical trial options with your healthcare team can provide more choices.

Conclusion

Advanced treatments for breast cancer offer new hope and improved outcomes for many patients. From targeted therapies and immunotherapy to personalized medicine and advanced surgical options, these treatments are designed to tackle cancer more effectively and with fewer side effects. For those seeking the best breast cancer treatment in Hyderabad, Dr. Chinnababu Sunkavalli is a top choice. Known for his extensive experience and advanced treatment methods, he provides expert care tailored to each patient’s needs.

Contact Dr. Chinnababu Sunkavalli today to explore the best breast cancer treatment options in Hyderabad and take the next step towards effective care.

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Buy Nolvaxyl online and reduce aromatizing effects of steroids

Nolvaxyl is a valuable tool in bodybuilding, with the active ingredient Tamoxifen. It is a selective estrogen receptor modulator (SERM) famous for its function as anti estrogens and is frequently used to manage or prevent estrogenic side effects that come from using anabolic steroids. Many pros buy Nolvaxyl online to block estrogen receptors of certain tissues, thereby keeping a hormonally balanced environment necessary for muscle gains and overall performance improvement. For more details click:

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Build Serious Muscle with Hi-Tech Pharmaceuticals 12 Week Mass Bulk Cycle Prohormone Stack

Are you ready to transform your physique and pack on serious muscle mass? The Hi-Tech Pharmaceuticals 12 Week Mass Bulk Cycle Prohormone Stack is designed to help you achieve impressive muscle growth, increased strength, and enhanced performance. This comprehensive program includes powerful prohormones and essential support supplements to maximize your gains and ensure optimal results. Let’s dive into the key components of this transformative stack and how each ingredient contributes to your muscle-building journey.

1-Testosterone for Lean Muscle Gains

1-Testosterone (1-Andro) is a potent prohormone known for its ability to promote lean muscle growth and improve strength. It converts to 1-testosterone in the body, which is highly anabolic and supports muscle hardness and density. For best results, take 200mg of 1-Testosterone daily throughout the 12-week cycle to maximize muscle gains and achieve a more defined physique.

Decabolin for Enhanced Strength and Performance

Decabolin (19-NorAndro) is another powerful prohormone included in the Mass Bulk Cycle. It converts to Nandrolone, a highly effective compound for increasing strength and performance. Decabolin helps improve muscle size and strength while supporting recovery and endurance. Take 150mg of Decabolin daily during the 12-week cycle to experience significant improvements in your lifting capacity and overall athletic performance.

Superdrol for Rapid Muscle Growth

Superdrol (Methyldrostanolone) is a well-known prohormone for its rapid muscle-building effects. It promotes significant muscle growth, strength gains, and enhanced muscle fullness. Superdrol is highly effective for those looking to bulk up quickly and achieve impressive size. Take 20mg of Superdrol daily for the first 6 weeks of the cycle to kickstart your muscle growth and build a solid foundation for the remainder of the program.

Dianabol for Increased Muscle Mass

Dianabol (Methandrostenolone) is a classic bulking prohormone known for its ability to increase muscle mass and strength. It enhances protein synthesis and nitrogen retention, leading to significant muscle growth and improved recovery. Take 20mg of Dianabol daily during the last 6 weeks of the cycle to continue building muscle and enhance your overall gains.

Arimistane for Estrogen Control

Arimistane (Androsta-3,5-diene-7,17-dione) is a powerful aromatase inhibitor included in the Mass Bulk Cycle to control estrogen levels. It helps prevent estrogen-related side effects such as water retention and gynecomastia, ensuring a lean and dry physique. Take 50mg of Arimistane daily throughout the 12-week cycle for effective estrogen control and to maintain hormonal balance.

Liver Support for Optimal Health

Given the potency of the prohormones included in this stack, it’s crucial to support your liver health throughout the cycle. A high-quality liver support supplement containing ingredients like Milk Thistle, N-Acetyl Cysteine (NAC), and TUDCA should be taken daily to protect your liver and ensure overall health. Follow the recommended dosage on the product label for best results.

Post-Cycle Therapy (PCT) for Optimal Recovery

After completing the 12-week prohormone cycle, it’s essential to follow a 4-week PCT to restore natural hormone levels and support overall recovery. The PCT phase includes the following components:

Clomid for Testosterone Recovery

Clomid (Clomiphene Citrate) is a selective estrogen receptor modulator (SERM) that helps stimulate the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), promoting natural testosterone production. Take 50mg of Clomid daily for the first 2 weeks of PCT, followed by 25mg daily for the remaining 2 weeks to ensure effective testosterone recovery.

Nolvadex for Estrogen Blockade

Nolvadex (Tamoxifen Citrate) is another SERM included in the PCT phase to block estrogen receptors and prevent estrogen-related side effects. Take 20mg of Nolvadex daily for the entire 4-week PCT period to support hormonal balance and overall recovery.

Natural Testosterone Booster for Additional Support

In addition to Clomid and Nolvadex, it’s beneficial to include a natural testosterone booster during PCT to further enhance recovery and support overall well-being. Look for a product containing ingredients such as Tribulus Terrestris, Fenugreek, and D-Aspartic Acid, and take it as directed for the entire 4-week PCT period.

Why Choose the Hi-Tech Pharmaceuticals 12 Week Mass Bulk Cycle Prohormone Stack?

The Hi-Tech Pharmaceuticals 12 Week Mass Bulk Cycle Prohormone Stack is a comprehensive and effective program designed to help you achieve significant muscle growth, increased strength, and improved performance. With its powerful combination of prohormones and a structured PCT phase, this stack provides everything you need to maximize muscle gains and support overall health. Whether you're aiming to bulk up, increase strength, or enhance performance, the Mass Bulk Cycle delivers.

Transform your body with the Hi-Tech Pharmaceuticals 12 Week Mass Bulk Cycle Prohormone Stack. Experience the power of this advanced supplement program and take the next step towards achieving your fitness goals!

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Curious About Tamoxifen in Bodybuilding? Discover Its Benefits, Risks, and What to Expect in This Comprehensive Guide

While exploring the depths of bodybuilding, I recently stumbled upon an insightful piece discussing the use of Tamoxifen on Insulin Reviews. This article delves into Tamoxifen’s role, predominantly known as a breast cancer treatment, and its intriguing application in bodybuilding.

Key Benefits Explored

Within the bodybuilding community, Tamoxifen is revered for its ability to counteract estrogenic side effects typically seen with anabolic steroid use. The article explains that this medication can help reduce gynecomastia, allowing bodybuilders to maintain a more defined chest. Additionally, it discusses how Tamoxifen potentially enhances the natural production of testosterone, aiding muscle growth and overall performance.

Understanding the Risks

The article doesn’t shy away from outlining potential risks. Users may experience side effects ranging from mild issues like hot flashes to more significant concerns such as blood clots and vision problems. It stresses the importance of medical supervision when considering Tamoxifen.

What's to Expect

In conclusion, the post provides a balanced viewpoint, helping readers to understand what to realistically expect when using Tamoxifen. It emphasizes the need for informed decisions and professional advice before incorporating it into any bodybuilding regimen.

If you're considering Tamoxifen, I highly recommend checking out this article for a comprehensive overview. It’s an essential read for anyone contemplating its use in their fitness journey.

[global-online-pharmacy]

Generic Exemestane brand Aromasin 25 mg Tablet Side effects

Aromasin belongs to a group of medicines known as aromatase inhibitors. These medicines interfere with a substance called aromatase, which is needed to make the female sex hormones, oestrogens, especially in postmenopausal women. Reduction in oestrogen levels in the body is a way of treating hormone dependent breast cancer. Aromasin is used to treat hormone dependent early breast cancer in postmenopausal women after they have completed 2-3 years of treatment with the medicine tamoxifen. Aromasin is also used to treat hormone dependent advanced breast cancer in postmenopausal women when a different hormonal drug treatment has not worked well enough.

Possible side effects

Very common: may affect more than 1 in 10 people

Depression

Difficulty sleeping

Headache

Hot flushes

Dizziness

Feeling sick

Increased sweating

Muscle and joint pain (including osteoarthritis, back pain, arthritis and joint stiffness)

Tiredness

A reduction in the number of white blood cells

Abdominal pain

Elevated level of liver enzymes

Elevated level of a hemoglobin breakdown in the blood

Elevated level of a blood enzyme in the blood due to liver damage

Pain

Above content source:  https://www.911globalmeds.com/info/1122-1-Exemestane-Aromasin-Medication-Patient-Information-In-English.pdf

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Breast Cancer Treatment Options: A Comprehensive Guide By the Breast Cancer Specialist in Surat

Fighting breast cancer is no easy task. Along with courage and a positive attitude, knowledge of treatment options also plays a vital role. For women in Surat, and across the globe, understanding breast cancer treatment options can make a significant difference in their journey towards recovery. We at BCI- Blood and Cancer Institute being one of the best cancer hospitals in Surat are witness to the numerous healthcare facilities now available to cancer patients. These facilities offer state-of-the-art treatments and compassionate care for breast cancer patients. Let’s delve into the various treatment options available, empowering women with the information they need to make informed decisions about their health.

1. Chemotherapy:

Chemotherapy involves the use of powerful drugs to kill cancer cells or prevent them from multiplying. While chemotherapy can cause side effects such as hair loss and nausea, advancements in medical science have led to more targeted therapies with fewer adverse effects. Our oncologists in Surat at BCI- Blood and Cancer Institute, work closely with patients to develop personalized chemotherapy regimens based on factors such as cancer stage, type, and individual health considerations.

2. Radiation Therapy:

Radiation therapy utilizes high-energy rays to target and destroy cancer cells. It is commonly employed after surgery to eliminate any remaining cancer cells and reduce the risk of recurrence. Experts at Blood and Cancer Institute (BCI), one of the best cancer hospitals in Surat, recommend modern radiation therapy techniques such as intensity-modulated radiation therapy (IMRT) and brachytherapy. These techniques precisely deliver radiation to the affected area while minimizing damage to surrounding healthy tissue, leading to better outcomes and fewer side effects.

3. Surgery:

Surgery is often the first line of defence against breast cancer. Cancer specialists in Surat are now well-equipped to perform various procedures tailored to each patient’s unique circumstances. Lumpectomy, where only the tumour and surrounding tissue are removed, may be an option for early-stage cancer. Mastectomy, on the other hand, involves the removal of the entire breast and may be recommended for more advanced cases. Surgical techniques have advanced significantly, offering options like nipple-sparing mastectomy to preserve the breast’s appearance.

4. Hormone Therapy:

Hormone receptor-positive breast cancers rely on hormones like oestrogen to grow. Hormone therapy aims to block or suppress the body’s production of these hormones, thereby slowing or stopping cancer growth. Drugs such as tamoxifen and aromatase inhibitors are commonly used in hormone therapy. Our healthcare facilities at Blood and Cancer Institute (BCI) offer access to these medications and closely monitor patients for effectiveness and side effects.

5. Targeted Therapy:

Targeted therapy identifies and attacks specific molecules or pathways involved in cancer growth. Unlike chemotherapy, which affects both cancerous and healthy cells, targeted therapy is designed to be more precise, minimizing collateral damage. We, targeted therapies such as HER2-targeted drugs are available for breast cancers that overexpress the HER2 protein. These therapies have revolutionized the treatment of HER2-positive breast cancer, significantly improving survival rates and quality of life.

6. Immunotherapy:

Immunotherapy harnesses the body’s immune system to recognize and destroy cancer cells. While still relatively new in the treatment of breast cancer, immunotherapy holds promise as a potential option for certain patients. Clinical trials exploring the effectiveness of immunotherapy in breast cancer treatment are ongoing in Surat and around the world, offering hope for improved outcomes in the future.

7. Clinical Trials:

Clinical trials play a crucial role in advancing breast cancer treatment options. By participating in clinical trials, patients in Surat have the opportunity to access cutting-edge therapies and contribute to scientific research. These trials evaluate new drugs, treatment combinations, and approaches to better understand and combat breast cancer. Healthcare providers can help patients explore clinical trial opportunities and make informed decisions about participation.

8. Comprehensive Care and Support:

Beyond medical treatment, breast cancer patients in Surat receive holistic care and support services to address their physical, emotional, and psychological needs. Support groups, counselling services, and survivorship programs offer invaluable resources and camaraderie for patients and their families. From diagnosis through survivorship, patients are surrounded by a compassionate network of healthcare professionals dedicated to guiding them through every step of their journey.

Conclusion

Understanding breast cancer treatment options empowers women in Surat in making informed decisions. From chemotherapy and radiation therapy to targeted therapies and immunotherapy, our healthcare facilities at Blood and Cancer Institute (BCI) offer a comprehensive array of treatments tailored to individual needs. The struggle to stay on top of this disease is draining for women. But by staying informed, seeking support, and exploring all available options, breast cancer patients in Surat can work towards healing with confidence and hope.

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Unlock Your Potential with Super PCT by Warrior Labz

Are you ready to optimize your hormone levels, support muscle growth, and enhance recovery? Look no further than Super PCT by Warrior Labz, a comprehensive post-cycle therapy supplement designed to help you maintain your gains and support overall health. Let's delve into the details and explore why Super PCT is the ultimate choice for anyone serious about their fitness journey:

1. Clomiphene Citrate:

Description: Clomiphene Citrate, also known as Clomid, is a selective estrogen receptor modulator (SERM) that helps restore natural testosterone production after a cycle of prohormones or anabolic steroids. It stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland, leading to increased testosterone production in the testes.

Dosage: The recommended dosage for Clomiphene Citrate in Super PCT is [dosage here] per day. This ensures optimal results in restoring testosterone levels and maintaining muscle mass.

2. Tamoxifen Citrate:

Description: Tamoxifen Citrate, also known as Nolvadex, is another SERM commonly used in post-cycle therapy. It works similarly to Clomiphene Citrate by stimulating the release of LH and FSH, but it also has estrogen receptor-blocking properties, preventing estrogen-related side effects such as gynecomastia.

Dosage: The recommended dosage for Tamoxifen Citrate in Super PCT is [dosage here] per day. This ensures effective estrogen control and hormone balance.

3. Arimistane (Androsta-3,5-diene-7,17-dione):

Description: Arimistane is a powerful aromatase inhibitor that helps reduce estrogen levels in the body. By blocking the conversion of testosterone to estrogen, Arimistane helps prevent estrogen-related side effects such as water retention and gynecomastia, allowing you to maintain a lean and defined physique.

Dosage: The recommended dosage for Arimistane in Super PCT is [dosage here] per day. This ensures you experience the full benefits of estrogen control while minimizing the risk of side effects.

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[arrangoiz]

Treatment of Hot Flashes in Women Taking Tamoxifen for Breast Cancer

Tamoxifen: Is indicated for premenopausal patients: With node-negative, hormone receptor positive, HER2-negative breast cancer: With low-risk recurrence scores (Oncotype Dx) Is a selective estrogen receptor modulator (SERM) with antiestrogenic activity in breast tissue: Reducing epithelial cell proliferation Hot flashes are one of the most common and bothersome side effects of…

[medicineforcare]

Xtane

Xtane is the brand name for exemestane, a drug used in the treatment of hormone receptor-positive breast cancer, particularly in postmenopausal women. It belongs to a group of drugs known as aromatase inhibitors, which reduce the body's production of estrogen. Reducing estrogen levels aids in slowing or stopping the formation of tumors since it can encourage the growth of some types of breast cancer.

Here are key details about Xtane (exemestane):

Uses:

Hormone receptor-positive breast cancer: mostly used to treat breast cancer with progesterone or estrogen receptors in postmenopausal individuals.

Adjuvant therapy: Occasionally used to stop cancer from returning following radiation or surgery.

Advanced breast cancer: frequently applied following the failure of other hormonal treatments, such as tamoxifen.

Mechanism of Action:

Aromatase inhibition: The enzyme aromatase, which transforms androgens (male hormones) into estrogen, is inhibited by exemestane. As a result, estrogen levels drop, which slows the growth of breast cancer cells that are dependent on estrogen.

Dosage:

Typically, 25 mg once daily, taken after a meal.

The dosage and length of treatment are based on individual conditions, so it’s important to follow the doctor’s guidance.

Side Effects:

Common side effects of Xtane may include:

Hot flashes

Fatigue

Joint or muscle pain

Nausea

Increased sweating

Insomnia

Less common but more serious side effects include:

Osteoporosis: Due to the reduction in estrogen, which is important for bone health.

Liver issues: Rare, but liver function should be monitored.

Heart problems: Risk of cardiovascular issues in some patients.

[healthbd]

What causes fatty liver disease?

Fatty liver disease, also known as hepatic steatosis, is a condition characterized by the accumulation of fat in the liver cells. This condition can range from mild to severe and is becoming increasingly common worldwide. As the Best Gastroenterology Doctor in Bangladesh, I've encountered numerous cases of fatty liver disease and have delved into its multifaceted causes.

Poor Diet and Lifestyle Choices:

One of the primary culprits behind fatty liver disease is an unhealthy diet high in saturated fats, sugars, and refined carbohydrates. Consuming excessive amounts of these foods leads to the deposition of fat in the liver, contributing to the development of hepatic steatosis.

Obesity and Metabolic Syndrome:

Individuals who are overweight or obese are at a higher risk of developing fatty liver disease. This is particularly true for those with abdominal obesity, insulin resistance, and metabolic syndrome. These conditions create a metabolic environment conducive to fat accumulation in the liver.

Insulin Resistance and Diabetes:

Insulin resistance, a hallmark of type 2 diabetes, plays a significant role in the pathogenesis of fatty liver disease. When cells become resistant to insulin, the body compensates by producing more insulin, leading to increased fat synthesis and storage in the liver.

Genetic Factors:

Genetic predisposition can also contribute to the development of fatty liver disease. Certain genetic variations can affect how the body metabolizes fats and predispose individuals to hepatic steatosis, even in the absence of significant dietary or lifestyle factors.

Medications and Toxins:

Certain medications, such as corticosteroids, tamoxifen, and some antiretroviral drugs, can cause or exacerbate fatty liver disease. Additionally, exposure to environmental toxins and excessive alcohol consumption can damage the liver and promote fat accumulation.

Rapid Weight Loss:

Sudden and significant weight loss, whether through crash dieting or bariatric surgery, can lead to the rapid mobilization of fat stores in the body, including the liver. This influx of fatty acids can overwhelm the liver's capacity to process and metabolize fats, resulting in hepatic steatosis.

Intentional Rapid Weight Loss:

Crash Dieting: Some individuals may adopt very low-calorie diets or fad diets that severely restrict food intake to achieve rapid weight loss. These diets often lack essential nutrients and can lead to muscle loss and metabolic imbalances.

Fasting: Fasting involves abstaining from food for extended periods, which can lead to rapid weight loss due to reduced calorie intake. While intermittent fasting has gained popularity for its potential health benefits, prolonged or extreme fasting can have adverse effects on metabolism and overall health.

Extreme Exercise: Excessive exercise, especially when combined with severe calorie restriction, can result in rapid weight loss. While regular physical activity is essential for health, overtraining can lead to fatigue, injury, and negative metabolic consequences.

Unintentional Rapid Weight Loss:

Underlying Medical Conditions: Certain medical conditions can cause unintentional weight loss, including hyperthyroidism, gastrointestinal disorders (such as celiac disease or inflammatory bowel disease), cancer, and chronic infections.

Medications: Some medications can suppress appetite, increase metabolism, or cause gastrointestinal side effects that lead to weight loss. Examples include stimulants, certain antidepressants, and chemotherapy drugs.

Psychological Factors: Mental health disorders like depression, anxiety, or eating disorders can affect appetite and lead to unintentional weight loss.

Potential Health Risks:

Rapid weight loss can have adverse effects on overall health and well-being, including:

Nutrient Deficiencies: Severely restricting food intake can lead to deficiencies in essential vitamins, minerals, and macronutrients, compromising immune function, bone health, and energy levels.

Muscle Loss: Rapid weight loss often results in the loss of lean muscle mass, which can slow metabolism and lead to a rebound effect where lost weight is regained.

Gallstones: Rapid weight loss increases the risk of developing gallstones due to changes in bile composition and reduced gallbladder emptying.

Electrolyte Imbalance: Dehydration and electrolyte imbalances can occur with rapid weight loss, leading to symptoms such as weakness, dizziness, and cardiac arrhythmias.

Healthy Weight Loss Strategies:

Aim for gradual weight loss: Losing 0.5 to 1 kg (1 to 2 pounds) per week is generally considered safe and sustainable.

Focus on balanced nutrition: Include a variety of nutrient-dense foods in your diet, and avoid extreme restrictions or elimination of entire food groups.

Incorporate physical activity: Combine aerobic exercise, strength training, and flexibility exercises for overall health and fitness.

Seek professional guidance: Consult with a healthcare provider or registered dietitian before starting any weight loss program, especially if you have underlying medical conditions or concerns about rapid weight loss.

Other Medical Conditions:

Certain medical conditions, such as celiac disease, Wilson's disease, and hypothyroidism, can predispose individuals to fatty liver disease. These conditions may directly affect liver function or metabolism, leading to fat accumulation in the liver. In conclusion, fatty liver disease is a complex condition with multiple contributing factors. As the Best Gastroenterology Doctor in Bangladesh, I emphasize the importance of addressing underlying risk factors through lifestyle modifications, dietary changes, and appropriate medical management. By understanding the root causes of fatty liver disease, we can develop targeted interventions to prevent and treat this increasingly prevalent condition effectively.