#endometrialcancer

[cytgen]

Abstract Worldwide, endometrial cancer is one of the most frequently diagnosed malignancies in women and a notable cause of death. The aim of this study was to perform image cytometric DNA ploidy analysis on a prospective material of endometrial adenocarcinomas in order to determine potential correlation between ploidy status and their histological features. The analysis was carried out in fresh tissue samples resected by implementing complete hysterectomy in a series of patients (n = 126). We found that ploidy status using image cytometry correlate with histologic type, grade and stage in endometrial cancer and aneuploid tumor samples are associated with aggressive phenotype statistics. Furthermore, DNA ploidy should be used as a reliable and applicable prognostic marker in the routine clinical practice.

Keywords: DNA ploidy Image cytometry diploid aneuploidy endometrial carcinoma endometrial cancer

[kkmedicalcentre]

How do hormonal changes, pregnancy, and menopause affect the risk of these cancers?

Hormonal changes, pregnancy, and menopause can influence the risk of gynaecological cancers in various ways: 1-Cervical Cancer:Pregnancy: Low risk, but hormonal changes may accelerate existing cancer.Menopause: Risk decreases, especially after cervical surgery.2-Ovarian Cancer:Pregnancy: Reduces risk, especially with full-term pregnancies.Menopause: Estrogen-based HRT may slightly raise risk.3-Endometrial Cancer:Pregnancy: Reduces risk via less estrogen exposure.Menopause: Obesity post-menopause may increase risk due to higher estrogen levels.4-Vulvar and Vaginal Cancers:Pregnancy: No significant impact.Menopause: Risk may rise due to age-related genital tissue changes.Regular screenings and medical consultations remain crucial for managing gynaecological cancer risks across life stages.

For more gynaecological cancers Related Information, Consult Dr. Kausha Shah one of the Best Lady Gynecologist in Dahisar or you can contact us on 9820190406.

[chloezara11]

An unexpected visit back to this place. It’s never straightforward and when things unfortunately arise you have to face them. 🧡🏥 #wombcancer #uterinecancer #endometrialcancer #cancer #oncology #hospital #gynecology #peachsisters https://www.instagram.com/p/CmKMkzAoAyT/?igshid=NGJjMDIxMWI=

[vshospitals]

Watch the full webinar on cancer in women conducted by both VS Hospital and Aval Vikatan.

Reach us on +91 9021123000 or visit www.vshospitals.com

[velagalaxy]

if its easier to cash app me that is expected ang appreciated so much. Thank you. $VelaGalaxy

https://www.facebook.com/donate/2887678404848029/?fundraiser_source=external_url

My baby bub says thank you!

[drcesaralara-blog]

Obesity And Cancer

Dr Cesar Lara

Obesity, the new smoking

Cancer is a terminal disease caused by inhibition of cell growth. It impairs the normal process of cell growth, transformation and even death (apoptosis).  Cancer invades cells, tissues, blood vessels and molecules, spread into them and destroys them. Cancerous cells have been linked to malignant tumors which are quite life threatening. Interestingly but quite disturbing, beyond the widely known causatives of cancer (exposures to carcinogens) which could be environmentally induced (radon and UV radiation exposure); biologically enhanced (genetics); occupationally facilitated (exposures to radioactive material) or lifestyle related (smoking, the most popular). Obesity is associated with increasing the risk of having cancer and it is fast replacing smoking. Most people know smoking to be a deadly cause of cancer but in recent time, there have been a decrease in smoking rate (obviously because of the fear of having cancer) and an increase in the obesity rate. According to the new American Cancer Society report, about twenty eight thousand (28,000) obese men and seventy-two thousand (72,000) obese women have been diagnoses with cancer in the U.S. Also, out of the 544,000 cancer diagnoses globally, 3.9 percent have been caused by obesity. At this point, it is pertinent to point out that being obese does not mean you have cancer; it only increases your chances of contracting cancer (the probability is kinda high). Now, intimating everyone on the connection between obesity and cancer is inevitable especially at this time that obesity is on a fast rise. Nevertheless, how obesity causes cancer has not been properly documented as the connection between them is still being explored by scientist. However, some probable ways through which obesity can be linked to the ‘killer cells’ have been discovered. This article will attempt to point out some of these dimensions.

How obesity causes cancer

The probable ways through which obesity induces cancer are succinctly explained in the succeeding headings; Hormonal increase Excess fat in the body leads to increase in hormone levels. An increase in such hormone like insulin and Insulin growth factor for instance has been linked with cancer. Of course, these hormones instruct the body cells to split on a sporadic rate.  In the process, cancer cells are birth. Once cancerous cells are produced, the normal hormonal activity that regulates cell growth is hindered. As such, the cells defying apoptosis (cell death) continue to split until a tumor is induced. Gradually, the body immune defence system is rendered powerless and death becomes imminent. Also, the intake of excessive sugar especially in high carbohydrate diet can increase insulin level and in turn, cause cancer. Visceral fats This body fat is stored around the abdominal cavity where it envelopes several critical body organs such as, the pancreas, the liver and the intestines. Usually, when this body fat is excessively accumulated by the body, it poses serious health risk to the body.  According to the American Institute for Cancer Research, visceral fat is a metabolic organ that produces the estrogen hormones which is linked to a higher incidence of breast and some other forms of cancer. Furthermore, these fats impacts on insulin level (it drives it higher) through protein secretion which stimulates cell growth, consequently, increasing the risk of contracting cancer. Impacts on immune-surveillance Natural killer Cells Normally, the body has its defence system known at the immune system. This is an army of white blood cells charged with the defence of the body against harmful bacteria and pathogens. But when excess fats storm a person’s body, the functioning of these cells becomes inhibited and compromised. According to a joint recent study by researchers from the Harvard medical school; trinity college of Dublin, UK; and the Brigham Women’s Hospital published in the Journal of Nature Immunology, the effect of obesity on the natural killer cells is quite profound. Their study found out that in obese people, the natural killers cells are clogged around by fat such that they are rendered powerless to perform their defence function. Cancerous cells in these fats churn down the powers of the immune system.

Cancer caused by obesity

In recent times, obese people have been identified with the increased risk of contracting esophageal cancer, colorectal cancer, pancreatic cancer, liver cancer, breast cancer (among post-menopausal women), prostate cancer, endometrium cancer and gall bladder cancer Breast cancer as it relates to obesity is prevalent in obese women who have passed the stage of menopause. The production of estrogen by fat tissues after menopause becomes the main hormone source. As such, where excess fat produces excess estrogen, the risk of breast cancer becomes high. Colorectal cancer affects the bowels (the colon and the rectum). It is caused by having excess belly fats (that is, a bigger waist line). Endometrial cancer affects women uterus especially after menopause. It is induced by excess estrogen levels caused by fat tissues which changes a hormone called androgen into estrogen, hereby, increasing the risk of having cancer. Endometrial cancer has been found common in many obese women. It is also twice common in overweight women when compared to women who have health weight. Pancreatic and liver cancer is caused by excessive visceral fats. These fats impair on the liver cells and pancreas cell, impacting upon their normal regulated functioning. Prostate cancer is also induced by altered level of serum in hormones such as testosterone, insulin, leptin and oestrogen. Gall bladder cancer is associated with the gall bladder which is a small organ beside the liver that produces bile which aids digestion. Excess fat in the body causes gall stone, consequently, increasing the risk of having cancer of the gall bladder. At this juncture, it must also be established that the recurrence of cancer is highly associated with obese persons than those with normal weights. More so, in obese patients, there exist cases of unwanted and more severe side effects arising from the treatment of cancer. For instance, there is the risk of treatment related lymphedema in obese breast cancer survivors and even death from myeloma for people with high level of obesity.

How to escape this

Basically, one of the keys to avoiding cancer risk is to avoid gaining weight in the first instance. You can achieve this by being conscious of what you eat and through regular exercise. A mostly organic/non-GMO plant base nutrition with some animal protein like fish, chicken, eggs, grass fed beef and healthy fats is key. Although, it is undeniable that it is a challenge to attain and maintain a healthy weight, nevertheless, there are compelling reasons to strive to do so. We must know that improving our nutrition enhances the ability of our body to heal itself. It also helps us to improve our blood pressure, cholesterol and glucose, hence, decreasing the risk for diabetes and heart disease. Most importantly, improving our nutrition helps us to decrease the likelihood of developing cancer. - - - - - - - - - - For more information visit: https://drcesarlara.com Follow Dr Lara @drcesarara on your favorite social media platform

References

https://www.medicalnewstoday.com/articles/323654.php https://www.nature.com/articles/s41590-018-0251-7 https://www.cancer.net/navigating-cancer-care/prevention-and-healthy-living/obesity-weight-and-cancer-risk https://www.cancerresearchuk.org/about-cancer/causes-of-cancer/obesity-weight-and-cancer/does-obesity-cause-cancer https://www.cancerresearchuk.org/about-cancer/causes-of-cancer/obesity-weight-and-cancer/does-obesity-cause-cancer https://www.medicalnewstoday.com/articles/155598.php https://www.cancer.org/cancer/endometrial-cancer/causes-risks-prevention/risk-factors.html https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179687/   Read the full article

[renew-healthcare]

We cordially Invite all fraternity of doctors for the CME on Optimizing fertility in Endometriosis & Enhancing its Success Rate of IUI By Rajeev Agarwal at Renew Healthcare Kolkata

[dragonflyarttuition]

Every year 6,600 women are diagnosed with gynaecological cancer - that’s 18 women a day - 2,100 of them will not survive. @womencanfund raises funds to support ANZGOG’s gynaecological cancer research that will improve outcomes for women now and in the future, you can support them by donating or taking part in their online auction and virtual gallery. Gyno cancer is incredibly close to my heart, and having held my gram’s hand through her own endometrial cancer journey, I am so honoured to be able to do my bit, be a small part of the narrative, and donate “I’ve Got You” to the Honour Her campaign. She’s the sister piece to my Du Rietz finalist “Growth,” and she represents self care, healing, and blooming despite pain. 100% of proceeds go to charity, so get on there and: A) buy some beautiful art And B) do something meaningful. #LiveBetterLiveLonger #HonourHer #HonourHer2022 #art #artist #auction #charity #cancer #endometrialcancer #gynocancerawareness (at Shellharbour, New South Wales) https://www.instagram.com/p/Ch9jUR0PcBd/?igshid=NGJjMDIxMWI=

[tabijozwick]

Infusion almost done. Hopefully this will be the last one. #cancer #cancertreatment #cancersucks #cancerstinks #cancerfight #cancerfighter #cancersurvior #endometrialcancer #endometrialcancerawareness #endometrialcancersurvivor #endometrialcancerfighter #endometrialcancersucks #uterinecancer #uterinecancerawareness #uterinecancersurvivor #uterinecancersucks #uterinecancerwarrior #endometrialcancerwarrior (at Illinois Cancer Care) https://www.instagram.com/p/Cg2KPs7O-nG/?igshid=NGJjMDIxMWI=

[fromsciencetopharma]

FDA approves Merck, Eisai’s Keytruda and Lenvima combination for endometrial cancer #fdaapproval #endometrialcancer “Merck and Eisai have secured approval from the US Food and Drug Administration (FDA) for Keytruda (pembrolizumab) plus Lenvima (lenvatinib) combination to treat patients with certain types of advanced endometrial carcinoma. This combination treatment is indicated for patients whose disease has progressed after systemic therapy in any setting and are not candidates for curative surgery or radiation. The FDA approval was based on data obtained from the Phase III KEYNOTE-775/Study 309 trial, where the combination of Keytruda and Lenvima significantly improved overall survival (OS) and progression-free survival (PFS), reducing the risk of death by 32% and the risk of disease progression or death by 40%. “ #MSL #FSTP #BCMSLcert #BoardCertifiedMSL #medicalscienceliaison medical science liaison #medicalaffairs https://lnkd.in/eHPQNkE https://www.instagram.com/p/CR0KNxcjsNW/?utm_medium=tumblr

[chloezara11]

View this post on Instagram

A post shared by Chloe Jackson (@chloezara94)

Uterine Cancer has been given an Awareness Month.. June.

Uterine Cancer is also known as Womb Cancer Or Endometrial Cancer.

My battle begin when I was just 24 years old and it still continues till this day.

This cancer is supposedly rare in young people but through this whole process I’ve learnt that so many young people are affected.

I had no clue what to look for regarding the signs or symptoms. This Cancer is rarely talked about, so how are we supposed to know when things go wrong.

Uterine Cancer is the most common gynecologic cancer.

Hearing that C word changes your life.

It’s time to put the spotlight on Uterine Cancer 🧡✨

#uterinecancer #wombcancer #endometrialcancer #awareness #gynecologiccancer #gynocology #cancer

[vshospitals]

Endometrial Cancer: Some of the Signs & Symptoms of Endometrial Cancer. For Appointments Call: +91-44-42001000 / +91-9962242000 / +91-44-46008000 #vshospitals #healthtips #chennai #Healthcheckup #cancersymptoms #cancertreatment #cancer #endometrialcancer https://www.instagram.com/p/B62BRtuFfVH/?igshid=c8siegdbovt6

[tonydianajday]

#LowGradeEndometrialStromalSarcoma #LGESS #LowGrade #cancer #endometrialcancer #rarecancer #StromalSarcoma #uterinecancer #raiseawareness #stage4cancer https://www.instagram.com/p/CIsDoK7BLHd755QyfBlG1f0rj5utRBeJvhRO480/?igshid=1po3xhvw4p11w

[tabijozwick]

Round two of iron infusion to treat cancer related anemia. #cancer #cancertreatment #cancersucks #cancerstinks #cancerfight #cancerfighter #cancersurvior #endometrialcancer #endometrialcancerawareness #endometrialcancersurvivor #endometrialcancerfighter #endometrialcancersucks #uterinecancer #uterinecancerawareness #uterinecancersurvivor #uterinecancersucks #uterinecancerwarrior #endometrialcancerwarrior (at Illinois Cancer Care) https://www.instagram.com/p/Cg12aX8OVyu/?igshid=NGJjMDIxMWI=

[newsinofficial]

Gynecologic Cancer Awareness Month: Early detection, knowledge can save lives

[fromsciencetopharma]

Merck, Eisai detail Keytruda and Lenvima's endometrial cancer win in confirmatory study #endometrialcancer #Keytruda #Lenvima “Keytruda and Lenvima cut the risk of death by 38% over physician’s choice of chemotherapy in patients with previously treated endometrial cancer regardless of their tumor’s mismatch repair status. Patients on the combo lived a median 18.3 months, versus 11.4 months for chemo takers, according to data presented at the virtual Society of Gynecologic Oncology (SGO) annual meeting on women’s cancer. The PD-1/TKI cocktail also pared down the risk of disease worsening by 44% in all comers. The results were similar in the mismatch repair proficient subgroup, as the treatment combo reduced the risk of death by 32% and the disease worsening by 40%. The Keynote-775 trial win will likely be enough to turn the Keytruda-Lenvima combo’s very first go-ahead, a conditional nod the FDA doled out in 2019 in previously treated endometrial carcinoma that’s not microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR), into a full one.” https://www.instagram.com/p/CMomraKjJvU/?igshid=s3vxps4k0vfb