#enkephalin (ENK)

[mehmetyildizmelbourne-blog]

Sleep Regulation Insights

I summarize the key points of an exceptional article about sleep regulation written by Dr Mehmet Yildiz on Medium.com.

Neurobiology of the Suprachiasmatic Nucleus A remarkable article by Dr Yildiz titled Sleep Regulation: Neurobiology of the Suprachiasmatic Nucleus explains how the brain regulates circadian rhythms and whether a literal “clock” exists within it in simple terms based on experience and research. Sleep is the cornerstone of human and organismal well-being, highlighted in my previous health and…

[camellia-office]

🍾 Heyhey~! It's Kat, from the Raven Office! Soo, uh, I'll cut to the chase. Gali's doing not very good and nothing that we can afford is working, sooo...

🐟 W-We're going to an L Corp. branch in our District...er, District 23. I-If it didn't get looted, there should be some Enkephalin left...and also, tools. We already sneaked out to locate it.

🍾 ...Yyyyuppers! Some good ol' enk and WHITE tools should do the trick for a while. Buut, considering our grade as Fixers and our E.G.O. gear's grade, we might face stuff way beyond our capabilities. SO! If any of you can come along, that'd be very awesome!

🍾 We could bring Gali over, but she's already dealin' with enough as is. We also don't really have that many relations with other Fixers. Plus, alot of y'all worked there too, no?

🍾 Also, what even is the right dosage of the stuff before I end up injecting Gali with enough L Corp. certified super crack to replace her blood with it and send her consciousness beyond the Outskirts?

- @theravenoffice

Don't sweat it, we're heading over to assist. -Daie

[mayhen-and-tears]

Limbus Grind

So let me breakdown this. You get 1 enk(Enkephalin) every 6 minutes, thats 10 enk per hour, thats 240 enk a day, every 20 enk is a enk box. The normal mirror dungeon is 5 floors, cost 5 enk box, and give 3 levels, thats 3 boxes, thats 3 shards if youre unlucky 9 if youre lucky and 6 normally. that means that you can play 4 mirror dungeons per day, and get 12 boxes per day. you need around 200 boxes (at least on my case) to get 400 for a tier 3 identity or ego. If youre crazy or just dont like the fact that the game is a gacha, you can convert your lunacy to enk (refresh your enk), meaning that you can get (its better to do at level 70 but 36 is not a bad idea) 6 enk box per convert (26, 52, 78, 104), that can be like 2 more mirror dungeons, thats 18 boxes, per day. The hard mirror dungeon give you 30 levels thats 30 boxes, but cost 18 enk box. so basically:

sun, mon, tue, thu, fri, sat > 4 mirror dungeons per day, 72 boxes Wed > 1 mirror dungeon, 30 boxes Total: 102

That means you can get half a identity per week if you dislike the gacha you can go all in and

sun, mon, tue, thu, fri, sat > 6 mirror dungeons per day, 108 boxes Wed > 3 mirror dungeon, 36 boxes Total: 144

Now, how much time does it cost you, i tried to answer this question, and basically its 1 hour per run for me using a full burn team focusing on doing it fast, the not hard mirrors are 48 minutes, and the hard ones are a little bit over an hour so i round it down, that means if you farm and gacha you will have to put 25 hours per week (or 39 if you dislike the gacha).

Now if you have the pass, wich is not that bad considering other gachas, you will get 3x the reward, that means, 306 with gacha, and 432 withouth. THATS ONE AND A HALF IDENTITIES PER WEEK, OR TWO IDENTITIES PER WEEK, LIKE WHAT. In my humble opinion they should increase the normal reward and give double if you have the pass cuz this is crazy.

[illumination-on-medium]

Sleep Regulation: Neurobiology of the Suprachiasmatic Nucleus by Dr. Mehmet Yildiz on EUPHORIA, Medium

He explains how the brain regulates circadian rhythms and whether a literal “clock” exists within it in simple terms based on experience and research.

Sleep is the cornerstone of human and organismal well-being, highlighted in my previous health and cognitive function stories. Without sleep, rest, and downtime, the brain’s vitality wanes. Nonetheless, in our contemporary era, there is a trend where some people shun sleep, resorting to alertness aids in pursuit of heightened productivity. I have compassion for millions of people who experience sleep deprivation, as I also struggled with it, causing severe health issues in my younger years.

Various neurotransmitters, such as glutamate and GABA, and neuropeptides, like vasopressin and vasoactive intestinal peptide, play essential roles in SCN function. These neurotransmitters help regulate the timing and coordination of SCN activity.

The retinohypothalamic tract (RHT) receives direct inputs from light-sensitive ganglion cells in the retina. It secretes glutamate into the core VIP regions of the SCN, regulating circadian rhythmicity.

Another neurotransmitter, pituitary adenylate cyclase-activating polypeptide (PACAP), found in retinal ganglion cells, helps relay light information and enhances glutamate’s action on the SCN.

The geniculohypothalamic tract (GHT) provides a secondary, indirect photic input mediated by various stimuli. In the SCN, GHT and RHT overlap in their innervation. GHT neurotransmitters include neuropeptide Y (NPY), GABA, and enkephalin (ENK).

You can read this insightful and comprehensive article via the link below if you want to improve your sleep.

He also simplified it in a new story:

Nuances of SCN, Circadian Rhythm, and Awareness of Key Biochemicals for Sleep Regulation

Understanding our body’s internal clock related to environmental factors (light/darkness) & the impact of hormones and neurotransmitters is critical to having a restful night’s sleep.

[genefish]

New in Pubmed: A Signaling Pathway to Mediate the Combined Immunomodulation of Acetylcholine and Enkephalin in Oyster Crassostrea gigas.

Related Articles

A Signaling Pathway to Mediate the Combined Immunomodulation of Acetylcholine and Enkephalin in Oyster Crassostrea gigas.

Front Immunol. 2020;11:616

Authors: Liu Z, Zhou Z, Wang L, Zhang Y, Zong Y, Zheng Y, Li M, Wang W, Song L

Abstract Molluscs have evolved a primitive but complete neuroendocrine-immune (NEI) system with a vast array of neurotransmitters to conduct both humoral and cellular immunomodulation. Previous studies have illustrated the immune functions of several key neurotransmitters. However, the combined effects of multiple neurotransmitters and the signaling pathway to mediate such immunomodulation have not been well-understood. In the present study, iTRAQ and LC-ESI-MS/MS approaches were employed to investigate the combined immunomodulation functions of two crucial neurotransmitters, acetylcholine (ACh), and [Met5]-enkephalin (ENK), in oyster Crassostrea gigas. A total number of 5,379 proteins were identified from hemocytes of oysters after the treatments with Ach and ENK separately or simultaneously, and 1,475 of them were found to be significantly up-regulated, while 1,115 of them were significantly down-regulated. The protein expression patterns in the groups treated by ACh and ENK separately were quite similar, which were dramatically different from that in the group treated by ACh+ENK. One hundred seventy-two proteins were found to be differentially expressed in all the three neurotransmitter treatment groups. Functional validation suggested that ACh and ENK possibly modulate the immune response in oyster hemocytes by enhancing pathogen recognition, cell apoptosis, and the enzyme activities of superoxide dismutase (SOD). Moreover, GO enrichment and co-expression network analyses implied that the combined immunomodulation of ACh and ENK might be mediated by p53, EGF-R-ErbB, and Fc gamma R (FcγR) signaling pathways. These results collectively indicated that multiple neurotransmitters executed a combined and ordered immune regulation through common signaling cascades in molluscs, which was under delicate control to maintain the homeostasis.

PMID: 32362893 [PubMed - in process]

from pubmed: crassostrea gigas https://ift.tt/3dhamFJ via IFTTT

[mehmetyildizmelbourne-blog]

Sleep Regulation: Neurobiology of the Suprachiasmatic Nucleus by Dr. Mehmet Yildiz on EUPHORIA, Medium

He explains how the brain regulates circadian rhythms and whether a literal “clock” exists within it in simple terms based on experience and research.

Sleep is the cornerstone of human and organismal well-being, highlighted in my previous health and cognitive function stories. Without sleep, rest, and downtime, the brain’s vitality wanes. Nonetheless, in our contemporary era, there is a trend where some people shun sleep, resorting to alertness aids in pursuit of heightened productivity. I have compassion for millions of people who experience sleep deprivation, as I also struggled with it, causing severe health issues in my younger years.

Various neurotransmitters, such as glutamate and GABA, and neuropeptides, like vasopressin and vasoactive intestinal peptide, play essential roles in SCN function. These neurotransmitters help regulate the timing and coordination of SCN activity.

The retinohypothalamic tract (RHT) receives direct inputs from light-sensitive ganglion cells in the retina. It secretes glutamate into the core VIP regions of the SCN, regulating circadian rhythmicity.

Another neurotransmitter, pituitary adenylate cyclase-activating polypeptide (PACAP), found in retinal ganglion cells, helps relay light information and enhances glutamate’s action on the SCN.

The geniculohypothalamic tract (GHT) provides a secondary, indirect photic input mediated by various stimuli. In the SCN, GHT and RHT overlap in their innervation. GHT neurotransmitters include neuropeptide Y (NPY), GABA, and enkephalin (ENK).

You can read this insightful and comprehensive article via the link below if you want to improve your sleep.

He also simplified it in a new story:

Nuances of SCN, Circadian Rhythm, and Awareness of Key Biochemicals for Sleep Regulation

Understanding our body’s internal clock related to environmental factors (light/darkness) & the impact of hormones and neurotransmitters is critical to having a restful night’s sleep.