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Pulmonary fibrosis

Pulmonary fibrosis is a lung disease that occurs when lung tissue becomes damaged and scarred.

This thickened, stiff tissue makes it more difficult for your lungs to work properly.

As pulmonary fibrosis worsens, you become progressively more short of breath. Signs and symptoms of pulmonary fibrosis may include:

Shortness of breath (dyspnea)

A dry cough

Fatigue

Unexplained weight loss

Aching muscles and joints Causes -Smoking -Underlying connective tissue diseases -Exposure to inhaled dust and toxins -Radiation therapy -Certain medications Complications of pulmonary fibrosis may include:

High blood pressure in your lungs (pulmonary hypertension).

Respiratory failure.

Lung cancer.

Blood clots in the lungs.

Lung infection

Lung collapse

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Global Idiopathic Pulmonary Fibrosis Treatment Market Size, Analysis and Industry Report 2019 – 2026

The global idiopathic pulmonary fibrosis (IPF) treatment market size is expected to reach a value of USD 5.2 billion by 2026, according to a new report by Grand View Research, Inc. It is anticipated to register a CAGR of 12.7% during the forecast period. Increasing R&D initiatives undertaken by companies and surge in cigarette smoking population are anticipated to boost the growth.

Rise in the initiatives undertaken by manufacturers to develop products with novel mechanisms is anticipated to fuel the IPF treatment market growth. For instance, FibroGen, Inc., is currently developing a drug, pamrevlumab - a monoclonal antibody that targets the connective tissue growth factor. The phase III trials of pamrevlumab are expected to be initiated in the first half of 2019. The drug has received fast track designation from the Food and Drug Administration (FDA).

An aging population can be expected to have far-reaching social, economic, and political implications on nearly all the sectors including the healthcare sector. An associated consequence of an increase in the geriatric population will be an increase in the incidences of various medical conditions requiring long-term care. Moreover, the growing geriatric population base in countries with large untapped opportunities such as China and Japan is anticipated to drive the market growth during the forecast period.

The dramatic increase in cigarette smoking population is one of the major drivers likely to have a positive impact on market growth. According to the U.S. FDA and Centers for Disease Control and Prevention (CDC), in 2018, more than 3.6 million high and middle school students were existing e-cigarette users. The number increased by 1.5 million since the last year. The uptake in the use of e-cigarette is expected to lead to the incidence of IPF.

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More Detailed Study:

MAPK Inhibitors segment held the largest market share in 2018. Esbriet is the first drug approved for the treatment of IPF

Tyrosine kinase inhibitor is the second largest segment and is expected to expand at a CAGR of 11.0%

Autotaxin inhibitors (GLPG1690) is expected to post lucrative CAGR. GLPG1690 is currently in phase III trial and is expected to be commercialized in 2022

U.S. led in 2018 due to high market penetration and high awareness pertaining to IPF

IPF treatment market in Japan is estimated to decline over the forecast period owing to patent expiry of Esbriet in 2018

Some of the major players operating in the Idiopathic Pulmonary Fibrosis treatment market are F. Hoffman La-Roche Ltd; Boehringer Ingelheim International GmbH; Galapagos; FibroGen, Inc.; Prometic Life Sciences Inc.; Bristol-Myers Squibb Company; MediciNova, Inc.; Merck & Co., Inc.; Novartis AG; and Merck & Co.

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Idiopathic Pulmonary Fibrosis

#IdiopathicPulmonaryFibrosis Market Landscape and Forecast As per DelveInsight’s analysts, the hashtag#IdiopathicPulmonaryFibrosismarket size in the 7MM was found to be hashtag#USD 1,700 million in 2017 and is expected to grow in the future years owing to the anticipated launch of hashtag#IPF emerging therapies during the forecasted period 2019-2028. The entry of late-phase potential drugs like hashtag#Pemrevlumab (FibroGen), hashtag#PLN–74809 (Pliant Therapeutics), hashtag#KD025 (Kadmon Corporation, LLC), hashtag#PRM151 (Promedior, Inc.), and many more may bring revolution in the hashtag#IPFtreatment by 2028. https://lnkd.in/fT9HZdS

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Thoracic Imaging, Author(s) Ashish Chawla, Publisher Springer, Edition 1st, ISBN 9789811325434, Pages 455, Binding Hardcover, Language English, Publish Year January 2019

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In the realm of rare fibrotic disorders, Pirfenidone emerges as a beacon of hope, offering a glimmer of relief for patients grappling with conditions characterized by excessive tissue scarring. This orally administered medication has gained attention for its ability to slow down the progression of fibrosis, a hallmark feature of diseases like idiopathic pulmonary fibrosis (IPF), systemic sclerosis, and other rare connective tissue disorders. for more please visit-

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Essential Information on Pulmonary Fibrosis: Causes, Symptoms, and Diagnosis

Pulmonary fibrosis is a condition that affects the lungs, causing scarring of the lung tissue. This scarring makes it harder for oxygen to pass through the lungs and into the bloodstream, leading to difficulty breathing and other respiratory symptoms. In this blog, we will discuss the causes, symptoms, and diagnosis of pulmonary fibrosis.

Causes of Pulmonary Fibrosis:

There are many causes of pulmonary fibrosis, including environmental factors, genetic factors, and autoimmune diseases. Some of the most common causes of pulmonary fibrosis include exposure to environmental toxins such as asbestos or silica dust, viral infections such as hepatitis C, and certain medications.

Symptoms of Pulmonary Fibrosis:

The symptoms of pulmonary fibrosis can vary depending on the severity of the condition. Some of the most common symptoms include shortness of breath, a persistent dry cough, fatigue, and weakness. Other symptoms may include chest pain, unexplained weight loss, and a loss of appetite. If you are experiencing any of these symptoms, it is important to seek medical attention immediately.

Diagnosis of Pulmonary Fibrosis:

To diagnose pulmonary fibrosis, your doctor will perform a physical exam and may order several tests, including a chest x-ray, a CT scan, and pulmonary function tests. Pulmonary function tests measure how well your lungs are functioning and can help your doctor determine if you have pulmonary fibrosis. In some cases, a lung biopsy may be necessary to confirm the diagnosis.

Treatment of Pulmonary Fibrosis:

While there is no cure for pulmonary fibrosis, there are several treatment options available to help manage symptoms and improve quality of life. These treatments may include medications such as corticosteroids or immunosuppressants, oxygen therapy, and pulmonary rehabilitation. In some cases, a lung transplant may be necessary.

Prevention of Pulmonary Fibrosis:

While it is not always possible to prevent pulmonary fibrosis, there are several steps you can take to reduce your risk. These steps may include avoiding exposure to environmental toxins such as asbestos or silica dust, quitting smoking, and staying up to date with vaccinations to prevent viral infections.

In conclusion, pulmonary fibrosis is a serious condition that can cause significant respiratory symptoms and impact quality of life. If you are experiencing any of the symptoms of pulmonary fibrosis, it is important to seek medical attention immediately. With early diagnosis and proper treatment, it is possible to manage the symptoms of pulmonary fibrosis and improve overall quality of life.

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Understanding Idiopathic Pulmonary Fibrosis (IPF) and the Role of Pirfenex 400

Idiopathic Pulmonary Fibrosis (IPF) is a chronic and progressive lung disease that affects the tissue and air sacs in the lungs, causing scarring and ultimately leading to respiratory failure. The term "idiopathic" means that the cause of the disease is unknown. While there is currently no cure for IPF, there are several treatment options available that can help manage symptoms and slow down the progression of the disease. Pirfenex 400, also known as Pirfenidone, is one such treatment option that has been shown to be effective in treating IPF.

Understanding IPF

IPF is a type of interstitial lung disease, which means that it affects the tissue and space around the air sacs in the lungs. The scarring that occurs in IPF makes it difficult for the lungs to function properly, leading to shortness of breath, coughing, and fatigue. The exact cause of IPF is unknown, but it is believed to be a combination of genetic and environmental factors.

IPF is a progressive disease, which means that it tends to get worse over time. In some cases, the disease can progress rapidly, while in other cases it may progress slowly over many years. There is no cure for IPF, but there are several treatment options available that can help manage symptoms and slow down the progression of the disease.

The Role of Pirfenex 400

Pirfenex 400 is a medication that belongs to a class of drugs known as anti-fibrotic agents. It works by reducing the production of certain proteins that are involved in the scarring process of the lungs. By doing so, it helps to slow down the progression of IPF and improve lung function.

Pirfenex 400 has been shown to be effective in reducing the decline in lung function over a period of one year. It has also been shown to reduce the risk of acute exacerbations, or sudden worsening of symptoms, which can be life-threatening in patients with IPF.

Dosage and Administration of Pirfenex 400

Pirfenex 400 is usually taken orally, with or without food, three times a day. The recommended dosage is 267 mg three times a day, which can be increased to 534 mg three times a day after two weeks if the medication is well-tolerated.

It is important to take Pirfenex 400 as prescribed by your doctor, even if you do not experience immediate relief from your symptoms. It may take several weeks or months for Pirfenex 400 to show its full effect, and stopping the medication prematurely may result in a worsening of the disease.

Side Effects of Pirfenex 400

Pirfenex 400 has a good safety profile and is generally well-tolerated by patients. The most common side effects reported by patients include nausea, diarrhea, and rash, but these are usually mild and can be managed with dose adjustments or symptomatic treatment.

It is important to discuss any side effects you experience with your doctor, as they may be a sign that your medication needs to be adjusted or that you need additional treatment.

Conclusion

Idiopathic Pulmonary Fibrosis is a chronic and progressive lung disease that requires long-term management. Pirfenex 400 is a medication that has been shown to be effective in slowing down the progression of IPF and improving lung function. As a long-term treatment option, Pirfenex 400 can help patients with IPF manage their symptoms and improve their quality of life. If you have been diagnosed with IPF, talk to your doctor about whether Pirfenex 400 may be an appropriate treatment option for you. It is important to work closely with your doctor to develop a treatment

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A Comprehensive Guide to Idiopathic Pulmonary Fibrosis

Idiopathic Pulmonary Fibrosis (IPF) is a chronic and progressive lung disease characterized by scarring or fibrosis of the lungs. The cause of IPF is unknown, and hence it is called idiopathic. IPF affects about 5 million people worldwide, and its prevalence is higher among people above 50 years of age.

Causes: The exact cause of IPF is unknown. However, research has shown that certain factors may increase the risk of developing IPF, such as age, smoking, environmental factors, genetic predisposition, viral infections, and gastroesophageal reflux disease (GERD).

Symptoms: The symptoms of IPF may vary from person to person and may progress over time. Common symptoms include shortness of breath, chronic dry cough, fatigue, weight loss, chest discomfort, and clubbing of fingers and toes.

Diagnosis: The diagnosis of IPF is challenging as its symptoms are similar to other lung diseases. To diagnose IPF, doctors may perform a physical examination, medical history review, blood tests, pulmonary function tests, chest X-rays, CT scans, and lung biopsy.

Treatment: There is no cure for IPF, and treatment aims to slow the progression of the disease and improve symptoms. Treatment options include pulmonary rehabilitation, oxygen therapy, medications such as corticosteroids and immunosuppressants, and lung transplant in severe cases.

In conclusion, IPF is a chronic and progressive lung disease of unknown cause. It affects millions of people worldwide and is more common among older individuals. The symptoms of IPF may vary and progress over time, making diagnosis challenging. Treatment options aim to slow down the progression of the disease and improve the patient’s quality of life. If you experience any symptoms of IPF, it is crucial to seek medical attention immediately to get an accurate diagnosis and appropriate treatment.