#intron

[cytgen]

Abstract The phenomenon of the positive influence of introns on the expression of a corresponding gene, which is called intron-mediated enhancement (IME), is characteristic of a wide variety of organisms, including nematodes, insects, mammals, fungi, and plants, and occurs due to an as-yet-undefined fundamental mechanism. IME introns have been used for a long time, in particular, in plant biotechnology. Understanding the mechanisms of this phenomenon allows predicting and easily generating stimulatory introns with the given properties and creating highly advantageous phenotypes. It will also give the greenlight to the use of IME in gene therapy and to improve the production of pharmaceutical proteins. In this review, we analysed previously proposed models of IME functioning mechanisms and identified factors that can directly or indirectly determine IME under different conditions and at different levels of gene expression, such as experimental methods of IME research, regulatory RNAs, sequence properties, intron position and orientation, factors at the levels of DNA, transcription, splicing, mRNA, translation, genes in which IME is detected, tissue specificity, repression and how some factors relate to each other by importance. Since there is no single mechanism of IME, and the effect may differ in different species, when modelling this process, only the cases of IME affecting the same level of expression should be compared with each other, taking into account the experimental conditions. Identifying the biological factors that may determine IME and the relationship between them will help in the future to create a corresponding data set suitable for machine learning and try to solve the mystery of the IME phenomenon using machine learning.

[balrog-slayer66]

Art by Masamune Shirow, cover of Machine Head 2

[raatopaikka]

Osuuskassat bank ad, Suomen Kuvalehti magazine n:o 6, 1961

[mindblowingscience]

Although you may not appreciate them, or have even heard of them, throughout your body, countless microscopic machines called spliceosomes are hard at work. As you sit and read, they are faithfully and rapidly putting back together the broken information in your genes by removing sequences called "introns" so that your messenger RNAs can make the correct proteins needed by your cells. Introns are perhaps one of our genome's biggest mysteries. They are DNA sequences that interrupt the sensible protein-coding information in your genes, and need to be "spliced out." The human genome has hundreds of thousands of introns, about 7 or 8 per gene, and each is removed by a specialized RNA protein complex called the "spliceosome" that cuts out all the introns and splices together the remaining coding sequences, called exons. How this system of broken genes and the spliceosome evolved in our genomes is not known.

Continue Reading.

[h0neytune-cherub]

Shirow Masamune

[iamthecheesesandwitch]

I’m taking a hard trigonometry class right now, and my school has free tutoring, so I went to get some help from a student tutor for a problem in my homework.

The tutor whipped out Chat GPT to get the answer when they started getting stuck on the problem, and idk what happened, but I became so appalled I froze for a few seconds and just stared at him. I asked him why he was using generative ai to tutor me and he said he used it for everything.

I left because fucking obviously, a tutor who uses Chat GPT to tutor obviously doesn’t know what they’re talking about. And I go back to my work and suddenly it just all clicks, and I understand it.

I think the power of my own spite led me to comprehension.

[savage-kult-of-gorthaur]

SCI-FI/MANGA LADIES OF YESTERYEAR -- AND SHE WEARS HER POWERED ARMOR SUIT SO WELL, TOO.

PIC(S) INFO: Mega spotlight on assorted images of an "Intron Depot" mech girl/nurse, artwork by Masamune Shirow, and reportedly used as cover art for "Super Comic Workshop: Machine Head" Vol. 9, c. 1990.

Sources: www.reddit.com/r/Spacegirls/comments/nfxwif, Pinterest, eBay, various, etc...

[realkaijuhavecurves]

God I need someone to explain to me how DNA and RNA work like you would to a child

[leossmoonn]

Y’all after this research paper is done imma be writing more 🙏🏼

[biology-geology-beaches-india]

TSRNOSS, p 789.

[buzzardss]

i dont understand mrna processing please just kill me

[lil-intr0-vert]

https://archive.org/details/intron-depot-2/page/n23/mode/2up

[innonurse]

Health IT: Investment funds plan to take company R1 RCM private in a deal valued at nearly $9B

- By InnoNurse Staff -

Health IT company R1 RCM will be acquired for $9 billion and taken private by investment funds connected to TowerBrook Capital Partners and Clayton, Dubilier & Rice.

The acquisition price of $14.30 per share represents a 29% premium from late February.

TowerBrook already holds a 36% stake in R1 RCM, which serves over 3,700 hospitals and 30,000 doctors with billing and revenue collection services.

The deal, valued at approximately $8.9 billion, has been approved by a special R1 board committee and awaits shareholder and regulatory approval. The company expects the deal to close by year-end.

Read more at ABC News/AP

///

Other recent news

A new PET/MRI probe could lead to the early detection of hidden diseases (Institute of Organic Chemistry and Biochemistry of the CAS/Medical Xpress)

New AI tool streamlines heart monitoring: fewer leads, same accuracy (Scripps Research)

OneBlood suffers a ransomware attack; the status of donor data remains uncertain (Fierce Healthcare)

Decoding life: A new AI model uncovers DNA’s hidden language at the Biotechnology Center of TU Dresden (TU Dresden)

An experimental AI method enhances doctors' ability to diagnose esophageal cancers and precancers (Medical Xpress)

AI can predict male infertility risk using a blood test, eliminating the need for semen (Toho University/Medical Xpress)

Clinical speech-to-text: African health tech startup Intron Health secures $1.6 million in pre-seed funding to develop AI for global health (TL Tech Labari)

[jjsfavgirl]

Pink Glasses

JJ Maybank x migraine prone!girlfriend

this is very much inspired by my boyfriend! Who always tell me to put my glasses on when we play video games or when I’m writing because I get really bad headaches(sorry Oliver I’m wearing them right now don’t worry) <3

Summary: JJ who makes his headache prone girlfriend wear her glasses even when she doesn’t want to.

Warnings: headaches, fluffy JJ again

-

There it was again, that horrifying feeling when your forehead burns and the words on your maths textbook began to shake. Another god awful headache.

Glancing at the pink case beside your laptop, you considered reaching in and grabbing the also pink glasses. You then remembered exactly what those frames look like on you, shuddering at the mental image you went back to your work.

“Hey, princess” you heard your boyfriend greet as he walked into your shared bedroom, placing his motorcycle keys on the best along with his jacket then approaching you in order to press a soft kiss on your forehead as he ran his tan fingers through your hair.

You smiled up at him weakly, enough for him to believe that your head wasn’t throbbing as the bright light from the window shined into your eyes and muttered a small hey.

You heard JJ groan from behind you as he stretched himself out on your shared floral sheets.

Rubbing your forehead in attempt to conflict with the penetrating pain that filled your head. It felt like your brain cells were running an illegal cock fight in your head.

“You okay, baby?” JJ asked sweetly, looking up from his phone as you turned around to meet his striking blue eyes.

“Yeah m’fine.” You faked another smile, trying to ignore how the corners of your lips turning up slightly made you head throb even more than it already was.

“I know you’re lying.” He began, getting up from the now dented bed, “is your head hurting again?” He knew you way too well.

“Seriously I’m fine.” You responded, picking up your pen from the wooden desk and attempting to write something, even though all the words seem to scramble into one blob on your pages.

You looked up to see your blonde boyfriend glancing between you and your glasses case.

“No.” You immediately responded, knowing exactly what he wanted.

“Yes.” He demanded, picking up the rosey pink case and pulling out the skinny frames. “You either stop studying or you put the glasses on.” He held out the glasses introns of you with a cocky smile and a raised eyebrow.

“You know I hate how they make me look.” You threw your pen down on the page, leaning back in your chair while looking up at the tanned boy.

“You look adorable in them.” He smiled, ushering the glasses closer to your face as you backed away from them in disgust. “Your head is hurting, I don’t want you to be hurt, baby.”

“Fine.” You sighed, snatching the frames out of his hands as he had a smug look on his face at his victory.

Slowly shoving the glasses on your face with a groan, you avoided gaze with JJ as you returned you eyes back to the textbook, your headache easing slightly already.

Cupping your cheeks with both his hands, he smushed your face together slightly as he turned you to face him.

“Such a pretty girl.” He murmured, smiling brightly down at you as his thumb grazed circles across your upper cheek.

You could only smile up at him, how could he make you feel this loved and this appreciated.

You had definitely chose the right guy.

-

Tag list: @chimindity @chiaraanatra

[littleeyesofpallas]

INTRON DEPOT