#mdsimulations

[cbirt]

A consortium of scientists from across the globe has undertaken a massive computational effort to produce predictive models on the effect of phosphorothioate (PS) stereochemistry on the structure and stability of the PS-DNA. RNA hybrid in the realm of gene silencing. Phosphorothioates have proven significant in oligonucleotide-based cancer and neurological disease therapeutics. PS-oligonucleotides have acquired a fundamental place in gene silencing-based therapeutics due to the increased nuclease resistance upon introducing PS substitution for antisense oligonucleotides (PS-ASOs). However, there exists a need for more knowledge pertaining to the effect of PS stereochemistry on DNA.RNA hybrids. The authors performed computational experiments aided by experimental measurements using NMR spectroscopy, thermodynamic analysis, and MD simulations to develop predictive models for a better understanding of this.

Antisense oligonucleotides (ASOs) are short single-stranded polymers designed to interact with RNA molecules, thereby affecting RNA functionality. They have been widely used to generate a therapeutic response in gene silencing-based disease management. Several of these have received FDA and EMA approval for treating various severe pathologies, and dozens more are expected to hit the market soon. The biological mechanisms related to ASO pharmacology are as follows: steric blockage of ribosomal binding, splice-switching, and RNAse H-mediated degradation of target RNAs.

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[biodiscovery-group]

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Glimpse of ongoing GROMACS, VMD & NAMD | 8 Day Technical Hands-on Certificate Training in MD Simulations by @bdglifesciences 👇👇👇 A new kind of program on both Windows OS & Linux for a unique learning experience 🎥🎥 Video recording of each session will be provided so to give user a unique learning experience - SELF-PACED - If you miss any session then NO PROBLEM you can still perform the tasks from the video and catch up in the next session. 👉👉 Registration for other events Check out LINK IN BIO . . . . . . #envisionwithbdg #itsdifferentbybiodiscovery #bdglifesciences #bioinformaticscompany #10yearsofexcellence #biotechnology #biotech #bioindia #biotechasia #bioinformatics #bioinfo #bioinfoindia #biotechindia #onlinebioinformatics #bioinformaticsworkshop #onlinebioinformaticscourse #bioinformaticsonlinetraining #proteomics #MDSimulations #GROMACS #linux #VMD #NAMD #rmsd #rmsf #radiusofgyration #proteinligandsimulations #Biophysics https://www.instagram.com/p/CRejwHRjbCM/?utm_medium=tumblr

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[biodiscovery-group]

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[biodiscovery-group]

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[biodiscovery-group]

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[biodiscovery-group]

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[biodiscovery-group]

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[biodiscovery-group]

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[biodiscovery-group]

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[biodiscovery-group]

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