#metastatic carcinoma

[timmyswiftie]

UPDATE !!! UPDATE !!! UPDATE !!!

SWIFTIE NURSE PA

Makena

So September 9th 2021 i get the news my cancer is back Terminal and I am down to 30 to 60 days left ... 7 days if it were to go to my brain , so I am in total breakdown mode and clearly in a daze and walking around in auto pilot, with treatment they can maybe get me a little more time if I were to agree, another round of Chemotherapy & Radiation and I do , so its about a month later I am in the Infusion Lounge getting my 6 hours of Chemotherapy when Dr walks by gives me a little look and a smile I return one as I am in conversation with her PA talking about what Taylor Music i am listening too.... a few minutes later I am in the treatment room for my appointment with Dr... she walks in and just looks at me and for the longest time saying nothing , like my God you can't have any worse news.... finally I say .... WHAT.... and she's like YOUR NOT TAKING THIS SOURIS ENOUGH YOUR DOWN TO LESS THEN 30 DAYS YOU WILL BE DEAD BY DECEMBER 30TH ...AND YOUR TALKING ABOUT WHAT SONG TAYLOR IS PLAYING ? My Reply..... I have Paid for my final Expenses I don't know what else you want me to do... AWKWARD

How we cope with even the worst of times its always TAYLOR

She gets us through it

THANK YOU. THANK YOU. THANK YOU

Taylor

[creepyscritches]

Clifton Strengths is wildly accurate but this blurb in the new report they sent me is unreal

Last year I set up a jeopardy game for a room of high level professionals and once they got their variety of buzzers (screaming chickens, kazoos, bells, etc) the room turned so silly and heehee you wouldn't believe it had you only seen the prior presentations.

Give a health care professional a rubber chicken and ask them what are the key documentation components for a psych diagnosis secondary to substance dependency and brother you're never going to cement that knowledge faster

[bpod-bpod]

Malignant Evolution

Multi-pronged (whole-exome sequencing, RNA sequencing, and Imaging Mass Cytometry) approach characterises at the single-cell level the heterogeneity of upper tract urothelial carcinoma – cancers arising in the ureter and the kidney's 'pelvis' – from primary to metastatic

Read the published research article here

Image from work by Kentaro Ohara and colleagues

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Nature Communications, March 2024

You can also follow BPoD on Instagram, Twitter and Facebook

[chxckens]

they biopsied some lymph nodes in my neck today which wasn't fun. they suspect a recurrence of my papillary thyroid carcinoma. if that's true, then i'd have two active cancers- this one as well as the metastatic adrenal cancer. who else out there is doing it like me!!!

[medixocentre1]

Unlocking The Potential Of Lenvatinib A Comprehensive Guide Understanding Lenvatinib Price

In the field of cancer treatment, where targeted medicines are changing the landscape of care, Lenvatinib 10 mg stands out as a promising medication for patients suffering from certain types of cancer; however, the lenvatinib price fluctuatesoccasionally. This article will provide a thorough examination of Lenvatinib 10 mg, providing light on its applications, mechanism of action, dosage, ability, side effects, and revolutionary effect on cancer treatment.

Introduction to Lenvatinib 10 mg

Lenvatinib is a tyrosine kinase inhibitor with demonstrated success in the treatment of a variety of malignancies, including thyroid cancer and hepatocellular carcinoma (HCC). The 10 mg dosage of Lenvatinib is a specific method geared to meet the healing needs of patients undergoing targeted treatment.

Mechanism of Action

Lenvatinib works by inhibiting a few receptor tyrosine kinases (RTKs), as well as vascular endothelial growth problem receptors (VEGFRs), fibroblast increase detail receptors (FGFRs), and platelet-derived boom element receptors (PDGFRs). Lenvatinib exerts anti-cancer effects by focusing on the major signaling pathways involved in tumor angiogenesis, development, and metastasis, which are ultimately necessary for tumor regression and advanced impacted character outcomes.

Uses of Lenvatinib 10 mg

Thyroid Cancer

Lenvatinib 10 mg is approved for the treatment of differentiated thyroid cancer (DTC) that is resistant to radioactive iodine therapy. It has demonstrated efficacy in slowing disease progression and improving improvement-free survival in patients with advanced or metastatic DTC. You can purchase it by obtaining information on lenvatinib prices from medical clinics or online.

Hepatocellular Carcinoma (HCC)

For patients with advanced HCC who are not candidates for surgical resection or network ablation, Lenvatinib 10 mg provides a valuable therapy option. It has demonstrated superiority over sorafenib, an excellent tyrosine kinase inhibitor, in terms of overall survival and progression-free survival in patients with unresectable HCC.

Dosages and Administration

Lenvatinib 10 mg is typically delivered orally once per day, with or without food. The dosage can be changed based on the affected person’s characteristics, such as frame weight, renal function, and tolerability. Healthcare personnel regularly monitor patients getting Lenvatinib medication, including regular examinations of tumor reactions and adverse effects to optimize treatment outcomes.

Potential Side Effects

While Lenvatinib 10 mg is generally well tolerated, it may produce adverse outcomes in certain patients. Common side effects of Lenvatinib medication include elevated blood pressure, lethargy, diarrhea, decreased appetite, nausea, and proteinuria. Patients are advised to immediately report any new or worsening symptoms to their healthcare providers for proper management.

Wrapping Up

Finally, Lenvatinib 10 mg represents a significant development in the treatment of thyroid cancer and hepatocellular carcinoma, providing improved outcomes and increased survival for patients with advanced or metastatic disease. Its concentrated mechanism of action, combined with its broad range of medical warning signals, emphasizes its importance in modern oncology. Patients are recommended to consult with their healthcare providers to learn more about the lenvatinib price, for personalized guidance, and for adapted control strategies when using Lenvatinib 10 mg. People can begin their treatment path with confidence and hope for a better future by understanding the intricacies of most cancers and investigating available therapy alternatives. Source:-

Unlocking The Potential Of Lenvatinib A Comprehensive Guide Understanding Lenvatinib Price

[hybridmindthoughtsreloaded]

Turbo Cancers

One interesting story that seems to be buried is all the young social media influencers from YouTube, Instagram, and TikTok that took the jab are getting turbo cancers.

July 9, 2023 – Sam and Colby (10 million subscribers) – 26 year old Colby Brock was diagnosed with testicular cancer. https://youtu.be/gn6nAkg9Ltw

July 3, 2023 – 37 year old Grace Helbig (2.6 million subscribers) Reveals She’s Battling Breast Cancer at 37 – she was diagnosed with Stage 2A Triple-Positive Breast cancer. https://youtu.be/QG2nTvma-ZE

Aug. 10, 2023 – Mexican TikTok Star, 25 year old Emilio Betancourt (3.2 million TikTok followers) announced he had cancer recurrence (Osteosarcoma) with no treatment options. https://youtu.be/YolbM7LheDA

May 26, 2023 – Buenos Aires, Argentina – 33 year old Aylen Milla (1 million Instagram followers) was diagnosed with very aggressive breast cancer. https://youtu.be/zo6QEq6ZJyk

May 19, 2023 – vlogbrothers (3.74 million subscribers) – with John Green and Hank Green. 43 year old Hank was diagnosed with Hodgkin Lymphoma. He promoted COVID-19 vaccines in 2021. https://youtu.be/x6a4hMyiwBo

May 16, 2023 – Mermaid Zelda (152k subscribers) was diagnosed with lymphoma. https://youtu.be/qfFlpwYjYmg

May 2023 – TikTok star Anthony Carrodo (500K TikTok followers) was diagnosed with lymphoma (DLBCL).

April 22, 2023 – Karina Reske (30.5k subscribers) was diagnosed with breast cancer recurrence and metastasis. She was in remission for 5 years. https://youtu.be/5bmJNuqHMHY

April 21, 2023 – Lizzy Musi Racing (66.2K subscribers) – was diagnosed with Stage 4 breast cancer. https://youtu.be/_iLcwRIwXyk

April 12, 2023 – Jessica Brock (63.7k subscribers) was diagnosed with three ovarian tumors up to 16cm, one was a malignant teratoma. https://youtu.be/4DYB4YWVU_4

March 4, 2023 – 21 year old Kyedae Shymko (1.1 million Instagram followers, 2.2 million Twitch followers), was diagnosed with Leukemia (AML). https://youtu.be/eUT9w8u2FUA

Feb. 4, 2023 – 39 year old Chad Wild Clay (14.7 million Youtube subscribers, 1 million Instagram followers) – was diagnosed with extremely rare myxopapillary ependymoma (spinal cancer). https://youtu.be/9FNXk3UDVxQ

Jan. 26, 2023 – Tiktok Influencer “Enkyboys” Randy Gonzalez (15.7 million TikTok followers, 2 million Instagram followers) announced in April 2022 he was diagnosed with Stage 4 Colon cancer. He was given 3 to 5 years to live by his doctors, he died 8 months later. https://youtu.be/mr7FGUy8h-0

Nov. 22, 2022 – 24 year old Andrea Barba (11.9k subscribers) – was diagnosed with Gastric Cancer (Stage 1B). https://youtu.be/j9r7ORs1k0E

Jul. 2022 – 33 year old Jenny Appleford (114k subscribers) was diagnosed with Stage 3 Lung cancer in March 2021 that has progressed rapidly to Stage 4 metastatic to brain. https://youtu.be/dHIhnM9T_gc

Jun. 30, 2022 – 23 year old Minecraft Youtuber Technoblade (16.5 million subscribers) died of metastatic sarcoma after being diagnosed in Aug. 2021. https://youtu.be/g9_aYyEDMD0

Jun. 19, 2022 – 36 year old Jessica Krock (Krocks in the Kitchen, 103k subscribers) – was diagnosed with Stage 3 Neuroendocrine carcinoma of the left ovary.

May 25, 2022 – Austin, TX – 39 year old Nasreen Shahi is a popular fashion blogger (477k Instagram followers) who was diagnosed with breast cancer late in 2021.

Apr. 21, 2022 – Tess Christine (2.3 million subscribers) was diagnosed with breast cancer in March 2022.

Jan. 23, 2022 – Eamon & Bec (1.23 million subscribers) – was diagnosed with stage 3 breast cancer in Dec. 2021.

Nov. 2021 – Stephanie Williams, Registered Nurse and TikToker (19K followers) was diagnosed with Stage 3 Lung cancer.

[dr-med]

Day 6

Didn’t do anything for science because I was back home from work at 10:30pm. Supervisor decided that she want to give me an 3 hour talk about me not being efficient or organised (was never a problem at academical hospital, only got excellent evaluations…) and it wasn’t a nice talk. When I came home I’ve seen that cat has shitten on the floor again… despite the second cat locked down. I really need to call cat psychologist…

Did an autopsy which was interesting with a lot of insights (not usually the case).

Slide shown on the bottom: when lymphoma meets metastatic carcinoma in liver biopsy

Gratitude:

- sour bread pre-dough risen first time!

- deep fried food in hospital restaurant

- TGIF!!

6/10/2023

[timmyswiftie]

Taylor Swift ....

Taylor Blessing my Clubs ...

[jcnnewswire]

LENVIMA(R) (lenvatinib) Plus KEYTRUDA(R) (pembrolizumab) in Combination With Transarterial Chemoembolization (TACE) Significantly Improved Progression-Free Survival Compared to TACE Alone in Patients With Unresectable, Non-Metastatic Hepatocellular Carcinoma (HCC)

http://dlvr.it/TDKJ9K

[medicineforcare]

Resihance

Resihance

Regorafenib   is a multi-kinase inhibitor used primarily for the treatment of cancer. It is particularly effective in targeting angiogenesis (the formation of new blood vessels), which plays a crucial role in cancer growth and metastasis. Below is a detailed overview of Regorafenib:

Mechanism of Action:

Regorafenib inhibits multiple protein kinases involved in tumor angiogenesis, oncogenesis, and the tumor microenvironment. Specifically, it targets:

VEGFR (Vascular Endothelial Growth Factor Receptor) – involved in blood vessel formation.

PDGFR (Platelet-Derived Growth Factor Receptor) – involved in the growth and survival of cells.

RAF kinases (including BRAF) – involved in cell proliferation and survival.

By blocking these pathways, Regorafenib reduces tumor growth and the spread of cancer.

Indications:

Regorafenib is used in the treatment of several cancers, including:

Colorectal Cancer: It is used in metastatic colorectal cancer (mCRC) that has progressed after standard therapy.

Gastrointestinal Stromal Tumors (GIST): It is prescribed for GIST after imatinib and sunitinib treatment have failed.

Hepatocellular Carcinoma (HCC): For patients with advanced liver cancer who have been previously treated with sorafenib.

Common Side Effects:

Fatigue

Hand-foot skin reaction (redness, swelling, pain in palms and soles)

Diarrhea

Hypertension (high blood pressure)

Nausea and vomiting

Abdominal pain

Decreased appetite

Weight loss

Serious Side Effects:

Liver toxicity: Regorafenib can lead to severe liver damage, including elevated liver enzymes, jaundice, and, in rare cases, liver failure.

Bleeding: Regorafenib can increase the risk of severe bleeding, especially in patients with cancer that has spread to the liver.

Cardiovascular complications: It can lead to high blood pressure and may increase the risk of heart attack or stroke.

Gastrointestinal perforation: A rare but potentially life-threatening complication.

Monitoring and Precautions:

Liver function should be monitored regularly because of the risk of liver toxicity.

Blood pressure should be checked frequently to detect any early signs of hypertension.

Skin reactions should be monitored closely, as they can affect the patient's quality of life.

Kidney function should also be assessed periodically, especially in patients at risk of kidney damage.

Pharmacokinetics:

Absorption: Regorafenib is well absorbed after oral administration but should be taken with a low-fat meal to ensure proper absorption.

Metabolism: The drug is metabolized in the liver primarily through CYP3A4, and its active metabolites also play a role in its efficacy.

Excretion: Regorafenib and its metabolites are excreted primarily through feces, with a small portion eliminated through urine.

[sisiad]

PD-L1 expression as a predictive biomarker in patients with recurrent or metastatic salivary gland carcinoma treated with pembrolizumab

http://dlvr.it/TCSPvw

[chestsurgeon]

Lung Metastasis Surgery in India - Dr. Pallavi Purwar

Lung metastasis surgery, also known as Pulmonary Metastasectomy (PM), is a critical procedure performed to remove metastatic lung nodules originating from primary cancers located elsewhere in the body.

Lung metastasis surgery in India offers not only top-notch medical care but also a unique and enriching experience for patients seeking treatment for this challenging condition.

[trodelvy]

Trodelvy: A Lifesaving Therapy for TNBC Available Across South Asia

Trodelvy, known scientifically as sacituzumab govitecan-hziy, is an innovative targeted therapy specifically approved for treating certain types of breast cancer, particularly triple-negative breast cancer (TNBC) that has metastasized or become inoperable. It is classified as an antibody-drug conjugate (ADC), a class of drugs that combines an antibody targeting cancer cells with a potent chemotherapy agent. This unique mechanism allows Trodelvy to deliver chemotherapy directly to cancer cells, significantly reducing damage to surrounding healthy tissues. Additionally, Trodelvy price in India is competitive, ensuring accessibility for a broader range of patients.

Mechanism of Action

Trodelvy targets Trop-2, a protein overexpressed in many solid tumors, including over 80% of breast cancers. The drug is engineered with a pH-sensitive linker that releases the cytotoxic agent, SN-38, once inside the cancer cell. This targeted approach not only enhances the treatment's efficacy but also reduces systemic side effects compared to traditional chemotherapy, offering a more precise attack on cancerous cells while sparing healthy tissues.

Indications and Usage

Trodelvy is primarily indicated for patients with metastatic TNBC who have already undergone at least two prior therapies, including one specifically for metastatic disease. It has also shown promise in treating other malignancies, such as urothelial carcinoma, in clinical trials. The treatment is administered intravenously, typically following a schedule of once a week for two consecutive weeks, followed by a week off, in a repeating 21-day cycle.

Efficacy Statistics

Clinical trials have demonstrated the significant efficacy of Trodelvy. In the ASCENT trial, focused on patients with metastatic TNBC, the overall response rate (ORR) was 31%, with 12% of patients experiencing complete responses. In a separate phase 2 clinical trial for bladder cancer, Trodelvy showed a response rate of 27.7%, with 22.3% of patients experiencing a reduction in tumor size of at least 30%. Moreover, 5.4% of participants had their tumors completely disappear, with a median duration of response lasting 7.2 months.

Trodelvy, a groundbreaking therapy for treating triple-negative breast cancer (TNBC), offers new hope for patients with metastatic or inoperable cases. Known for its targeted action, Trodelvy is now accessible across South Asia, including Afghanistan, Bangladesh, Bhutan, India, Maldives, Nepal, Pakistan, and Sri Lanka. With a competitive Trodelvy price, this life-saving medication is more widely available to those in need.

[trendingreportz]

DNA Vaccines Market - Forecast(2024 - 2030)

 DNA Vaccines Market is forecast to reach revenue of $9.43 Billion by 2025, growing at a CAGR of 33.86% during the forecast period 2020-2025. DNA vaccines are composed of deoxyribonucleic acid, which encodes antigens and stimulates a wider range of immune responses in the body with few side effects. DNA based Vaccines concept deliver to cells after which the gene is expressed and can generate the protein of interest. Clinical trials of some DNA vaccines have shown promising results in the treatment of several types of cancers like metastatic melanoma, prostate carcinoma, pancreatic cancer, and other solid tumors. The demand for DNA Vaccines is experiencing rapid growth owing to factors such as adoption of DNA Vaccines in Healthcare, Low cost, Increasing Technology, fewer side effects, increasing awareness about Health professionals and others. With the rise of COVID-19 pandemic throughout the world 

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Key Takeaways

North America dominates the DNA Vaccines Market owing to the increasing prevalence of infectious diseases in countries such as U.S and Canada.

Adoption of DNA Vaccines in Healthcare, Low cost, Increasing Technology, fewer side effects, increasing awareness about Health professionals are some of the key factors which are leading the demand for DNA Vaccines.

With the current COVID-19 Outbreak there is a huge demand for vaccination that can hack to build better immunity in order to fight the virus

Detailed analysis of the Strength, Weakness, and opportunities of the prominent players operating in the market will be provided in the DNA Vaccines Market.

By Type – Segment Analysis 

Based on the types, the DNA Vaccines Market is segmented into Human DNA Vaccines and Animal DNA Vaccines. Animal DNA vaccine is dominating the market in 2019 and is estimated to grow at a CAGR of 19.8% during the forecast period 2020-2025. This is owing to the unavailability of human DNA vaccines in the market along with the rising incidence of canine melanoma and other animal diseases. Animal vaccines are third generation vaccines and contain DNA that codes for specific proteins from a pathogen. This DNA is injected into host body and produces protein for which the body generates immune response. Moreover, the strong pipeline of human targeted vaccines is likely to aid in the market growth

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By Application – Segment Analysis

Based on the applications, DNA Vaccines Market is segmented into Human Diseases which includes applications in Oncology, Infectious Disease, Allergies, and Veterinary Disease. The Veterinary Disease based on application is forecast to grow at a higher CAGR during the forecast period 2020-2025 owing to availability of DNA vaccines for animal diseases that includes canine melanoma vaccine (DOG), West Nile Innovator (Horse), Life tide-SW5 (Swine and other food animals) and Apex-IHN (Salmon fish). 

By Geography – Segment Analysis

Based on the geography the DNA Vaccines Market has covered globally viz North America, South America, Europe, Asia Pacific (APAC) and Rest of World (ROW). The Market in North America accounts for 43.7% of the total market share, which is attributed by government initiatives to immune citizens, coupled with high awareness regarding the benefits of genetic vaccines targeted towards animals. 

Asia Pacific region is set to be the highest growth during the forecast period 2020-2025 owing to rising awareness of people regarding the advantages of immunization against HPV and Hepatitis B. Additionally, it is estimated that the DNA Vaccines Market is set to grow exponentially during the forecast period 2020-2025 owing to COVID-19 outbreak.

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Market Drivers - DNA Vaccines Market

Rising Demand for effective treatment of infectious disease in driving market

DNA Vaccines used to kill and stop the growth of microorganisms. These drugs can act as a defense system for the human body and neutralize the action of disease causative agents. With increasing research activities and Increasing awareness and extensive R&D drugs, there is rising demand for treatment of infectious diseases

Challenges - DNA Vaccines Market

The main area of uncertainty is related to the immunological impact, tissue distribution and persistence after injection and whether the DNA vaccine can leak into the environment. This, in turn, create a challenging point for the growth of DNA Vaccine. Also, with, the limited efficiency of plasmid-based techniques precluded their use in the creation of more accurate human cell models is one of the challenges for DNA Vaccine Market

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Vitamin & Mineral Industry Outlook

Product launches, mergers and acquisitions, joint ventures and R&D activities are key strategies adopted by players in the DNA Vaccines Market. In 2019, DNA Vaccines Market share is consolidated by the top ten players present in the market. DNA Vaccines Market Top 10 companies include Inovio Biomedical Corp, Merck & Co., Mitsubishi Tanabe, Dendreon Corporation, ASTELLAS PHARMA, Dynavax Technologies, Sanofi, Tekmira Pharmaceuticals GlaxoSmithKline Corp, Protein Sciences Corp.among others.

Acquisitions/Product Launches

In February 2020, Merck& Co announced the formation of a new, independent publicly-traded company focused on its Women’s Health, trusted Legacy Brands, and Biosimilars business. 

In February 2019, Merck & Co announced its acquisition of Immune Design Corp for nearly $300 million, gaining access to its immunotherapy programs.