#research activity 1

[lonestarflight]

Space Shuttle Enterprise and the 747 SCA landing after the second manned captive test flight on Runway 22 at the Edwards Air Force Base, California.

Date: June 28, 1977

source

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[darkwood-sleddog]

because i had to (politely) warn/criticize an acquaintance musher who was out on the trail in 86% humidity and 80F weather running their dogs on a rig when i was there today, i thought now was a good reminder that:

dogs do not cool down effectively when it is more humid

dogs that have previously suffered heat stroke are more at risk of developing it again and will do so more easily than a dog who has never had heat stroke. This ALONE is a great risk to sled dogs.

in the northern hemisphere a majority of dog heat stroke incidents take place in July (which is the month I'm writing this).

most mushers do not recommend running dogs in harness over 50F. No your dogs are likely not an exception. All dogs can develop heat stroke.

HERE is a post with a helpful chart from the Australia Sledding Sports Association about how to determine a safe combination of humidity and heat to run in. (it is in Celcius, but the combination of what we walked in today was easily a 26 on this chart.)

Some mushers CAN train dogs during the summer. Those that are in much more arctic conditions where early am may sometimes be frosty this time of year are clear to do so. Although the Mush with P.R.I.D.E. Sled Dog Welfare Guide has some warnings about the risks running dogs in hot weather poses. Their description of heat stroke even mentions snow which, yes, is true. Sled Dogs can easily overheat even in snowy conditions. Even then though, the summer mushers i see (who are in like...the Yukon...) are regularly monitoring temperatures and not running when it is above 50F.

and look. I've been at the receiving end of weather temperature criticism myself. I once ran Sigurd and Zombie on a like...60F degree evening in summer as a novice and my mentor tore me a new one. I felt bad (and cried lol), but it is what it is and i never did it again. It's also why working with and/or seeking advice from sport veterans is important. I will also never stall or refuse to tell somebody they're posing a risk to their dogs, not only bc i care for their animals well beings, but because mushers pushing dogs like this does reflect badly on the sport.

The one thing i do to make sure i'm aware of how hot my dogs may be besides monitoring the temperatures? I overdress whenever i take them out.

[thepastisalreadywritten]

The remainder of the crew’s time in orbit was spent carrying out nearly 40 science experiments and research, including some that sought to better understand space adaptation syndrome — a type of microgravity-specific motion sickness.

Gillis, a trained violinist, also brought her instrument along for the mission and delivered a rendition of “Rey’s Theme” from “Star Wars: The Force Awakens.”

Gillis’ music was sent back to Earth using SpaceX’s Starlink as a test of the satellite network’s potential to provide in-space connectivity.

Menon also took time to read a book she coauthored — called “Kisses From Space” — to her family as well as a group of patients from St. Jude Children’s Hospital as part of a fundraiser.

Sunday’s anticipated return marks the conclusion of the third trip to space for the specific Crew Dragon capsule powering the Polaris Dawn mission.

The spacecraft — named “Resilience” by the NASA astronauts onboard its first trip to space in November 2020 called (Crew-1) — flew the 2021 Inspiration 4 mission.

That trip, also funded by Isaacman, saw him and three crewmates circle Earth for three days as part of a fundraiser for childhood cancer research.

[the-busy-ghost]

There are many reasons my interests are more geared towards mediaeval Scotland than mediaeval England, but at least one of them has to be the fact that I am completely incapable of Being Normal about the Lion in Winter and Shakespeare's second tetralogy.

[waywardvagabonds]

“Umremarkable.” Thank god.

[bleakfortune]

lalala la la lal ala la u dont have to read this your decision heed the warning tag

[void-tiger]

Trying to keep a lid on it but. Yeah. Literally don’t know what’s it like to NOT be platonically neglected IRL my whole damn life, only that I know this One Person doesn’t deserve to be at the epicenter of it anymore than I deserved to have been at the epicenter of theirs a year ago now.

…why am I like this. Why are we like this.

[ruvviks]

thinking about jesse my son jesse

[astrxealis]

hiii :333 i think i am alive !! ( small update in da tags )

[tiffanyachings]

‘task involving a series of steps that need to be completed in a specific order’ voted greatest enemy of getting things done for 25th year in a row

[lonestarflight]

Space Shuttle Enterprise on 747 SCA with landing gear deployed to check clearance after flt MC-2.

Date: June 28, 1977

NASA ID: EC77-7707, EC77-7613, EC77-7614

[lady-harrowhark]

after nearly three years... over two hundred cases... unknown dozens of meetings... more than a thousand videos... and one last short-notice late-night data entry triage session...

i have just submitted the final dataset for my parent-child relationship video coding project for analysis

i feel like i need to smash a gameshow buzzer or something

[thesleepiestselkie]

oooouughhhh i am doing so bad at this whole bedtime thing

[shadybug]

Wait ur a system? I (may or may not be, no diagnosis) too! Idk I am one of your moots I’m just shy to talk about it when I’m not 100% certain of it. Without proof, I just call the other women in my head ghosts, they seem to prefer being called that??? I have no idea why I’m messaging if I’m not gonna come off anon tbh

yep!! i've got DID, more specifically ^^ i don't put it in my bio or anything bc i like keeping some plausible deniability (ableism's a bitch and this tumblr's not very hard to link to me irl), but i've been slowly being more open about it. it's awesome to see someone else with a similar situation, details/diagnosis aside!! if you ever want someone to chat about it with, you're always welcome to dm or come off anon ^^ but also i get that being vulnerable about these sorts of things is hard, so no pressure ofc

[phantomrose96]

Thinking about Edward Elric as the Amestrian Military's specialest little unfireable boy

State alchemists can be fired for underperforming. We know this up front from the likes of Shou Tucker. And this makes a ton of sense from the homunculi's standpoint since the state alchemists are sacrifice candidates, and the homunculi would want to cull the weakest candidates and focus only on cultivating the strongest ones who stand the best chance of opening the portal.

........Then there's Edward. Who's already opened the portal.

There's no need to cultivate him. No gamble taken on whether he's good enough to open the portal. He passed the final test already. Graduated 4 semesters early.

And as such, has a free pass to do Absolute Fuck All.

And I'm imagining how funny this is from like an outside perspective.

Some newish state alchemist who'd only ever read up on the stories of Edward Elric, ready and excited to start their career of being paid handsomely with endless freedom to research and travel and do anything they want in the pursuit of science... surprised and confused to find themselves put on probation their first month for things like "ignoring orders." Which is, as best they had thought, a famous Edward Elric pastime.

Roy showing a slight bit of stress about his yearly state alchemist report, and Ed just snorting and rolling his eyes at Roy because every year HE just hastily does his on the train ride over (canon in the manga, a travesty it was left out of the anime) and it gets rubber stamped. Ed not realizing that other alchemists' reports get genuinely scrutinized and torn apart while Ed is free to turn in whatever absolute bullshit he thinks of 36 hours ahead of time. One year his report was about whether alchemy could be done via dance (conclusion: no it can't) and no one cared. Roy WANTS to tell Ed there's some kind of unknown favoritism around Ed making him literally bullet-proof but Roy has no way to phrase this that doesn't sound like he's just in denial and mad at how good Ed's train-reports are.

Guy from the Internal Amestrian Affairs sector who's responsible for auditing other internal military personel for any suspicious activity hitting about 1 million red flags for Edward Elric, issuing a STRONG and URGENT recommendation to suspend the alchemist pending further investigation into things like "literal bunk-buddies with two members of the Xingese royalty (enemy nation)" and "spent $10,000,000 of his stipend on a librarian to make her re-copy (what he seemed to interpret as?) military records in some extremely transparent effort to unearth state secrets (it was a recipe book but he was literally asking her about state secrets)" and "literally has never once obeyed an order, ever, not even once in his career, and is on public record having said 'I do not care about the goals and protections of the Amestrian Military. I am in fact only pursuing my own interests several of which are diametrically opposed to the safety and well-being of the governing body of Amestris'"

The issued recommendation is intercepted before it even reaches its intended desk. President Bradley himself has taken issue with it and denies it before a single set of eyes has seen it. The President's veto stamp is a terrifying hammer, used rarely, and it is now sitting on the auditor's desk.

The auditor sleeps with one eye open from then on out.

[catboybiologist]

“As a biologist, the terms biological woman and man don’t make any sense to me” okay then you’re an idiot and a terrible biologist. I swear to god, morons like you only become biologists just so you can hold it over others, when in reality, if biology deniers like you can become biologists, then being one really doesn’t mean much anyway. But this probably just gave an autogynophile like you a boner to read, anyway.

Oh fun! Haven't gotten one of these in a while. Disregarding the fact that you somehow think the qualification for being a biologist entirely hinges on defining womanhood, I do need to ask some clarification. I know I'm feeding the trolls here, but here we go: does your definition of "biological woman" mean:

Sociological woman? Eh, context dependent, I'm not fully out of the closet, but oftentimes, I am and present femme. So let's call that one 50/50.

Psychological woman? Because I am one.

Neurological woman? Because I am one [1].

Physical woman? My soft tissue redistribution is handling that well.

Hormonal woman? My blood tests are within cis female ranges.

Transcriptional woman? As a signalling molecule, the downstream effects of estrogen have broad transcriptional effects, completely changing the profile of gene expression and functional genomics of my cells. [2]

Genetic woman? I mean, see my above point- as far as my genes that are actually active, I have all of the same transcripts being produced, controlling which genes are expressed.

Karyotypic woman? I actually have a few signs pre-HRT that might point to a non-XY chromosome pair, but I haven't had a karyotype. We'll put that down as unknown. And hell, even if its XY, there's plenty of cis women who are karyotypically XY, with suppressed sry or complete androgen insensitivity. Interestingly enough, a completely androgen insesitive woman can go her whole life without knowing- and functionally, is very similar to a trans woman, actually. Fancy that. [3]

Reproductive woman? I can't produce an egg cell, but neither can significant fractions of cis women. Also, this is all gonna change soon, which is fun. [4]

There's also a lot of understudied aspects to the biology of HRT and even pre-HRT that are emerging, largely demonstrating widespread cellular and genetic remodeling of trans individuals undergoing hormone therapy. The field is a bit behind due to constant political pressure to revoke funding, but a lot of the results are extremely exciting in both testosterone and estrogen hormone therapies. I'm sure that, as a self professed biology As someone who presumably has a lot of expertise in biology, I'm assuming that you're aware of all of this cutting edge research, and are keeping up with modern papers, including but not limited to these cool findings:

Trans men on HRT exhibit significant genetic and transcriptional changes that make them biochemically male. [5][6]. It's a good hypothesis that the same happens with estrogen treatment, but those studies don't exist yet- I'm sure you're reserving judgment until more publications exist, of course.

Trans men on HRT develop male cell types and tissues. [7]

Trans women experience muscular and blood cell changes that align with cis women moreso than cis men [8]

And many, many more! This is an exciting, underserved, and groundbreaking field of research, and I'm sure you're keeping up with the latest in scientific journals about it.

I'm sure, of course, that you understand that it becomes impossible to draw a distinct line anywhere in here, and that words like "woman" are shorthand for the myriad of traits that invisibly synthesize in our mind and in society to represent a concept? I'm sure you understand that science is fundamentally descriptive, not prescriptive? I'm sure that you understand that these findings, while really cool and interesting, actually don't mean jack shit about what the word "woman" means or not?

As someone who is the ultimate decider in what a biologist is, I'm sure you know that bioessentiallism is a childish mindset that completely ignores and disregards the constantly changing, dynamic nature of biological systems, something that extends well beyond biological sex and its relation to gender.

I'm sure that also, that you understand that beyond just this, that the role of science in society is to advise how to achieve our moral principles, not create moral principles in themselves. And I'm sure that understanding means you know that trans affirming healthcare and supportive societal treatment leads to reduced mortality and increased happiness for everyone, right?

So great to talk to someone who is surely a scientist on this. You are a biologist, if you're talking like this, I assume? I assume you're not going to spit complete misreadings of scientific language from the background sections of these papers that only reveal you've never read a scientific paper in your life if you're thinking this way? I assume you have experience interpreting data like this?

Also, imagining my genitalia while writing this? Ew. Please stop projecting your fetishes into my inbox.

Works cited:

Kurth F, Gaser C, Sánchez FJ, Luders E. Brain Sex in Transgender Women Is Shifted towards Gender Identity. J Clin Med. 2022 Mar 13;11(6):1582. doi: 10.3390/jcm11061582. PMID: 35329908; PMCID: PMC8955456.

Fuentes N, Silveyra P. Estrogen receptor signaling mechanisms. Adv Protein Chem Struct Biol. 2019;116:135-170. doi: 10.1016/bs.apcsb.2019.01.001. Epub 2019 Feb 4. PMID: 31036290; PMCID: PMC6533072.

Gottlieb B, Trifiro MA. Androgen Insensitivity Syndrome. 1999 Mar 24 [Updated 2017 May 11]. In: Adam MP, Feldman J, Mirzaa GM, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2024. Available from: https://www.ncbi.nlm.nih.gov/books/NBK1429/

Murakami, K., Hamazaki, N., Hamada, N. et al. Generation of functional oocytes from male mice in vitro. Nature 615, 900–906 (2023). https://doi.org/10.1038/s41586-023-05834-x

Pallotti F, Senofonte G, Konstantinidou F, Di Chiano S, Faja F, Rizzo F, Cargnelutti F, Krausz C, Paoli D, Lenzi A, Stuppia L, Gatta V, Lombardo F. Epigenetic Effects of Gender-Affirming Hormone Treatment: A Pilot Study of the ESR2 Promoter's Methylation in AFAB People. Biomedicines. 2022 Feb 16;10(2):459. doi: 10.3390/biomedicines10020459. PMID: 35203670; PMCID: PMC8962414.

Florian Raths, Mehran Karimzadeh, Nathan Ing, Andrew Martinez, Yoona Yang, Ying Qu, Tian-Yu Lee, Brianna Mulligan, Suzanne Devkota, Wayne T. Tilley, Theresa E. Hickey, Bo Wang, Armando E. Giuliano, Shikha Bose, Hani Goodarzi, Edward C. Ray, Xiaojiang Cui, Simon R.V. Knott, The molecular consequences of androgen activity in the human breast, Cell Genomics, Volume 3, Issue 3, 2023, 100272, ISSN 2666-979X, https://doi.org/10.1016/j.xgen.2023.100272. (https://www.sciencedirect.com/science/article/pii/S2666979X23000320)

Xu R, Diamond DA, Borer JG, Estrada C, Yu R, Anderson WJ, Vargas SO. Prostatic metaplasia of the vagina in transmasculine individuals. World J Urol. 2022 Mar;40(3):849-855. doi: 10.1007/s00345-021-03907-y. Epub 2022 Jan 16. PMID: 35034167.

Harper J, O'Donnell E, Sorouri Khorashad B, McDermott H, Witcomb GL. How does hormone transition in transgender women change body composition, muscle strength and haemoglobin? Systematic review with a focus on the implications for sport participation. Br J Sports Med. 2021 Aug;55(15):865-872. doi: 10.1136/bjsports-2020-103106. Epub 2021 Mar 1. PMID: 33648944; PMCID: PMC8311086.