#stemCells

[willygarciamunoz]

Stem Cells. A versatile polypharmacology platform promotes cytoprotection and viability of human pluripotent and differentiated cell

Human pluripotent stem cells (hPSCs) are capable of extensive self-renewal yet remain highly sensitive to environmental perturbations in vitro, posing challenges to their therapeutic use. There is an urgent need to advance strategies that ensure safe and robust long-term growth and functional differentiation of these cells. Here, we deployed high-throughput screening strategies to identify a small-molecule cocktail that improves viability of hPSCs and their differentiated progeny. The combination of chroman 1, emricasan, polyamines, and trans-ISRIB (CEPT) enhanced cell survival of genetically stable hPSCs by simultaneously blocking several stress mechanisms that otherwise compromise cell structure and function. CEPT provided strong improvements for several key applications in stem-cell research, including routine cell passaging, cryopreservation of pluripotent and differentiated cells, embryoid body (EB) and organoid formation, single-cell cloning, and genome editing. Thus, CEPT represents a unique poly-pharmacological strategy for comprehensive cytoprotection, providing a rationale for efficient and safe utilization of hPSCs.

[viezec]

What You Need To Know About Causes Of Liver Disease?

Liver disease | Hepatitis | Cirrhosis | Fatty liver disease | Liver failure | Liver fibrosis | Alcoholic liver disease | Liver regeneration | Liver stem cells | Best Treatment For Liver Disease | Stem Cell Treatment For Liver Disease | Exosome Therapy | Regenerative Medicine | Stem Cell Therapy Center For Liver | Organ Disease |

There are many different types of liver disease, each with their own unique set of causes. However, there are some commonalities among the various types of liver disease that are worth noting. Firstly, liver disease is often caused by excessive alcohol consumption. This can damage the liver cells and lead to scarring of the organ, known as cirrhosis. Obesity is another major risk factor for developing liver disease, as it can lead to fatty deposits building up in the liver and eventually causing inflammation. Viral infections such as hepatitis C are also a common cause of liver disease and can result in chronic inflammation of the organ.

https://shorturl.at/EhzqA

Email id- info@viezec.com

Ph no- +91 9650760803

[wtfearth123]

Scientists can grow cardiac tissue in a petri dish using stem cells. The cells self-organize to form microchambers, which begin to beat like a full-sized heart. Recent tissue engineering approaches have provided solutions to issues such as cardiomyocyte immaturity and inability to recapitulate adult heart values for features like contraction force, electrophysiology, or metabolism.

[storedapear]

The Role of Stem Cells in Aging: Unlocking the Secrets of Regeneration and Longevity

Aging is a universal journey—an intricate tapestry of experiences that shapes who we are, both inside and out. While the outward signs of aging—like wrinkles or slower reflexes—are easy to see, a more profound story unfolds at the microscopic level. At the heart of this story are stem cells—our body’s master repair system.

What Are Stem Cells?

Stem cells are extraordinary. Unlike most cells in our body that have specific roles (such as muscle cells for movement or nerve cells for communication), stem cells are unspecialized but immensely powerful. They have the rare ability to multiply and transform into various types of cells, making them essential for development, maintenance, and repair.

From the moment of conception, stem cells orchestrate the building of our organs, blood, and tissues. Embryonic stem cells can become virtually any cell in the body, while adult stem cells—found in places like bone marrow, skin, and the gut—stand by throughout life to repair damage and regenerate tissue.

Stem Cells and the Aging Process

As we age, stem cells lose some of their regenerative magic. Cuts take longer to heal, muscle strength wanes, and immune responses slow. This decline in stem cell function is a major contributor to aging. But what causes this change?

One critical factor is the stem cell niche—the local environment that surrounds and supports stem cells. This niche provides signals that regulate how stem cells behave. With age, the niche itself becomes less supportive due to inflammation, reduced circulation, and the buildup of waste. As a result, stem cells divide less frequently and become less effective at healing.

Additionally, stem cells accumulate damage over time. Each time a cell divides, errors in DNA replication can occur. Combined with exposure to toxins, radiation, and metabolic stress, these errors build up, causing stem cells to lose their regenerative capacity—or in some cases, begin to malfunction.

Visible Impacts of Stem Cell Decline

The effects of diminishing stem cell activity are evident throughout the body:

Skin: Thinner, less elastic, more prone to wrinkles.

Muscles: Gradual loss of strength and mass, a condition known as sarcopenia.

Blood and immune system: Slower recovery from illness and increased susceptibility to infections.

Brain: Declining neurogenesis may contribute to memory loss and cognitive decline.

Can We Rejuvenate Stem Cells?

Yes—and that’s where things get exciting.

Scientific advances are revealing ways to revive aging stem cells or replace them altogether. Researchers are experimenting with reactivating dormant cells, editing faulty genes, and even transplanting young or engineered stem cells to treat age-related diseases like osteoarthritis, heart failure, and Alzheimer's.

Stem cell science has shifted our view of aging itself—from a one-way decline to a dynamic interplay of damage and repair. With the right interventions, it may be possible to extend not just lifespan, but healthspan—the number of years we live in good health.

Supporting Stem Cell Health Naturally

While we await more advanced therapies, there are practical steps anyone can take to protect and support their stem cells:

Exercise regularly: Boosts circulation, reduces inflammation, and supports cellular health.

Eat a nutrient-rich diet: Vitamins, minerals, and antioxidants help repair cellular damage.

Avoid toxins: Limit exposure to pollutants, chemicals, and tobacco smoke.

Try intermittent fasting: Some studies suggest it may activate stem cell activity and enhance longevity.

Reduce chronic stress: Stress hormones can impair stem cell niches and reduce their effectiveness.

A Hopeful Future

Stem cell research has revolutionized our understanding of aging. It offers the hope that we can not only slow the march of time but actively enhance the body’s ability to regenerate. Though we still have much to learn, one thing is clear: aging is not just about breakdown, but also about renewal—and stem cells are at the center of that story.

CTA: Explore premium nutrition to support your inner wellness and shop trendy fashion that keeps you glowing at www.dapear.com. Join our wellness email list at www.manishgoswami.com for tips, exclusive offers, and health inspiration. Questions? Reach out anytime at info@manishgoswami.com

[fatihulusoy]

CL1: The Biological Computer That Plays Pong with Actual Brain Cells

Greetings folks! Strap in, because this one's not science fiction — it’s science right now. What you’re about to read involves a computer that thinks using actual, living brain cells. Cortical Labs has built a system that doesn’t just simulate intelligence — it is intelligence. Meet CL1: a hybrid of silicon, stem cells, and sheer bioengineering brilliance.

TL;DR:

Cortical Labs built a biological computer using living neurons from stem cells. These neurons live on a chip, respond to stimuli, and learn to play Pong through feedback. No lines of code needed — just raw, biological learning. It’s a new chapter in computing where machines grow brains instead of running on silicon alone.

🧠 So, What Is CL1?

Imagine this: you take living neurons — derived from either human or mouse induced pluripotent stem cells (iPSCs) — and grow them on top of a microchip covered in electrodes. These electrodes can talk to the neurons using electrical pulses.

Now give that system a goal — say, playing Pong — and watch what happens. With no pre-programming, these little neuron networks start to learn, just by reacting to inputs and adjusting over time.

This isn't a simulation. These are real cells doing real-time problem solving. Welcome to the era of wetware.

⚙️ CL1's Technical Side:

Neurons: Human/mouse neurons derived from iPSCs

Interface: Multi-Electrode Array (MEA)

OS: biOS (as base biological operating system)

Feedback Loop: Electrical stimulation + live response tracking

Learning Mechanism: Hebbian plasticity ("neurons that fire together wire together")

🧬 How the Heck Does This Actually Work?

Let’s break it down — both biologically and technically:

👾 The Digital-to-Bio Feedback Loop:

CL1 is a closed-loop system:

The digital system tells the neurons what's happening (e.g., “pong ball moving left”)

Neurons fire back electrical responses

The system interprets those firings

Correct response? They get rewarded. Wrong one? They get a gentle digital slap

Over time, the neuron network self-organizes, learning the task through synaptic plasticity

🧪 The Biology Bit:

The neurons are grown from induced pluripotent stem cells (iPSCs) — adult cells reprogrammed into a stem-cell-like state

These are then developed into cortical neurons

The network grows on a multi-electrode array that can both stimulate and read from the cells

🖥 The Tech Stack:

biOS (Biological Operating System): Simulates digital environments (like Pong) and interprets neural activity in real time

Signal Processing Engine: Converts biological signals into digital responses

Environmental Control: Keeps the neuron dish alive with precise nutrient feeds, CO₂ levels, and temperature management

💡 Why This Is a Huge Freaking Deal

This isn't about playing Pong. It’s about building a new class of machines that learn like we do. That adapt. That grow. This rewires the concept of computing from algorithm-based logic to biological self-organization.

Potential future uses:

Ultra-low-power, self-learning bio-AI chips

Medical models for brain diseases, drug testing, or trauma simulation

Robotic systems that use real neurons for adaptive control

In short: this is the birth of organic computing.

🔮 Can We Upload Knowledge Yet? Like Matrix Style?

Not quite. Right now, CL1 learns via real-time feedback — it’s still trial-and-error. But researchers are exploring:

Pre-conditioning neural responses

Chemical memory injection

Patterned stimulation to train in behaviors

In the future? We might literally write instincts into neural systems like flashing a bootloader. One day, your drone might come preloaded with lizard-brain reflexes — not software, but neurons.

🧱 What Comes Next?

We’re at the beginning of something radical:

Neural prosthetics with muscle memory

Bio-computers that can evolve new solutions on their own

Robots that aren’t just “smart” — they’re alive-ish

CL1 is laying the foundation for a new kind of intelligence — not modeled after the brain, but actually made of one.

🔗 Sources:

Cortical Labs Official

Nature Article

The Verge Feature

ABC Science News

MIT Tech Review

Neuron Journal Study

[globalgenerex]

Exosome Therapy Benefits: How It Works with Stem Cell Treatment |

Exosomes are found in various body fluids, including blood, urine, saliva, and cerebrospinal fluid. They are involved in processes such as immune response, inflammation, and tumor growth. Their ability to transfer bioactive molecules makes them potential therapeutic agents for a range of diseases.

https://globalregenex.com/what-is-exosome-treatment-and-its-benefits/

Email id- info@globalregenex.com Ph no- +91 7827791242

[globalstemcellcare]

🛑 World No Tobacco Day 🛑 🌍 May 31st | A Global Call to Quit

Tobacco kills over 8 million people every year, and countless more suffer from chronic illnesses caused by smoking and nicotine exposure. On this World No Tobacco Day, Global Stem Cell Care stands united with the world in raising awareness about the devastating health impacts of tobacco.

🚭 Say No to Tobacco. Say Yes to Life. Tobacco use is a leading cause of cancer, heart disease, and lung disorders.

✅ Quit today to breathe easier, live longer, and protect your future. ✅ Support your loved ones in their journey to quit. ✅ Choose a healthier path with preventive care and regenerative medicine.

🔬 Regenerative health begins with a single step—saying no to tobacco.

[cytgen]

Abstract Peripheral nerve injury (PNI) is a relevant biomedical problem, especially in wartime, given the high frequency of such injuries. Bioengineering means for rehabilitative treatment of PNI are considered the most promising, among which the effect of stem cell transplantation into the subarachnoid space on the process of plastic reconstruction of the nervous system in the context of PNI is the least studied. In this study, we investigated the effect of delayed transplantation of two types of human stromal multipotent stem cells into the cisterna magna on the restoration of the functional index of the sciatic nerve (sciatic functional index, SFI) after its transection and immediate epineural suturing in adult rats. The obtained data indicate that delayed intrathecal xenotransplantation of dermal multipotent stromal stem cells or multipotent mesenchymal stem cells, derived from the wall of umbilical artery, performed 2 weeks postinjury, leads to a significant increase in SFI after 2.5 months of observation. In the case of umbilical artery-derived stem cells’ injection, this result is significantly higher than the result of sciatic nerve suturing without the procedure of cell transplantation.

[gixntjelly]

I have already started to record my activities in subtle ways but I keep loosing track of where I keep these documentation. So I’d rather keep a journal to account for all of my things including my reflective thinking and next steps forward.

I have realised keeping track of my feelings, thoughts (when I keep myself in check) the things around me run a lot more smoothly than when I’m hot and bothered about not saying something or not remembering something.

So turning to journal writing again seems like the right thing to do.

Journaling is probably the wrong term I’m using maybe “blogging” would fit my current context but I am also planning to run this along side my instagram account only because there’s a different level of technology that each app carries and either each app comes a different beauty.

I hope to stay consistent in these apps because I have a 50/50 relationship with constantly being on my phone (insta) which I’ve negatively associated in my mind. So I have to reverse the though get into good habits and start forward thinking again about being on my phone (this time with a purpose).

Demystifying science was the start and end of my website gixntjelly. I had my fun while the website lasted but I am engaged in science communication, still, but more focussed within my masters and what’s in my area of interest. So you will find science content and videos and blogs of any creative projects that I am currently working on.

[chrisbacktolife]

Christoph Muth – Fighting a Rare and Devastating Neurological Disorder

Christoph Muth from Duisburg, Germany, is battling a rare and medically complex multisystem neurological disorder triggered by a medication switch from Escitalopram to Duloxetine. Since then, he has been suffering from a progressive Post-Acute Withdrawal Syndrome (PAWS) with severe sensorimotor, autonomic, and central nervous system disturbances — a condition barely documented worldwide.

Medically confirmed findings include:

Small fiber neuropathy

Autonomic nervous system dysfunction

NMDA receptor antibodies (suggesting autoimmune encephalitis)

Cerebellar and cortical changes

Pronounced neuroimmunological reactions

Multiple antibody processes now active simultaneously

Despite numerous outpatient treatment attempts — including one in Switzerland and others in North Rhine-Westphalia — no lasting stabilization has been achieved. The condition continues to worsen. Further inpatient treatments are currently being prepared. Some therapeutic protocols, such as EECP, advanced infusion programs, or stem cell approaches, need to be repeated and expanded. Many of these are not covered by health insurance.

Christoph urgently needs financial support to continue these innovative approaches in neuroregeneration.

SAT.1 NRW has already reported on his case. Still, broader public awareness, medical networking, and donation support are desperately needed for Christoph and others facing ultra-rare neuroimmunological diseases.

More information and the donation campaign can be found here:

https://gofund.me/e20cae20

www.chrisbacktolife.com

[researchatory]

Lab-Grown Spine! Amazing New Model Grown from Stem Cells | @researchatory

This is a major step forward in understanding the human spine! Researchers have grown a lab-based model that mirrors early spinal development, potentially leading to breakthroughs in treating spinal conditions and birth defects.

#LabGrown #Spine #research #SpineResearch #StemCells #Organoids #humandevelopment #regenerativemedicine #SpinalHealth #medicalbreakthrough #ScienceNews #labgrown #Research #Innovation #sportsmedicine #biology #stemcellresearch #notochord #developmentalbiology

It's important to note: This is a simplified model and not a fully formed human spine. It develops for only a few days and cannot form an embryo. However, it represents a significant step forward in our ability to study human development and spinal disorders using lab-grown models, also known as organoids. This falls under the exciting field of regenerative medicine, which aims to understand, repair, replace, or regenerate human cells, tissues, or organs to restore or establish normal function.

By @imaakashkhurana For more details join our medium page. (https://medium.com/@researchatory)

[obtener2]

"Stem Cell Therapies Could Treat Parkinson’s Disease by Rebuilding Lost Circuitry in the Brain, Studies Suggest: Two small clinical trials tested the safety of injecting stem cells into the brains of Parkinson’s patients and found no adverse effects." Smithsonian

[prateekcmi]

Tissue Engineering: An Emerging Field in Regenerative Medicine

Tissue engineering is an interdisciplinary field that applies the principles of engineering and life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function. The goal of tissue engineering is to generate functional organ or tissue replacements for damaged or aging tissues. By combining scaffolds, cells, and biologically active molecules, tissue engineers are developing biological substitutes to restore or improve tissue function.   Tissue Engineering  - https://coherent-market.hashnode.dev/tissue-engineering-a-promising-approach-for-restoring-and-regenerating-damaged-organs  

[drsuhyunanus]

Suhyun An Discusses How CBP Enhances Regenerative Medicine Treatments

Join Dr. Suhyun An as she explores how Chiropractic Biophysics (CBP) enhances regenerative medicine treatments like stem cell therapy and PRP. Learn how proper spinal alignment optimizes healing, reduces pain, and improves treatment outcomes. Don’t miss this insightful discussion! 

[globalgenerex]

🌍🚭 World No Tobacco Day 🚭🌍

Today, on World No Tobacco Day, we stand with the global community to raise awareness about the harmful effects of tobacco and advocate for healthier, smoke-free lives.

At Global Regenex, we believe in empowering individuals to choose life over addiction, healing over harm, and wellness over withdrawal.

💔 Tobacco use damages nearly every organ in the body 🧠 Increases risk of chronic disease, cancer, and respiratory illness ❤️‍🩹 Slows down the body’s natural regenerative process

Let this day be a reminder: Your body has the power to heal – give it the chance.

Choose a healthier future. Say NO to tobacco, and YES to regeneration. 🌱