#tbx2

[tedbearbelly]

FIRST PERSON TO GET THE REFERENCE GETS A COOKIE!

[caesarsaladinn]

Numerous genes encoding transcription factors and signaling ligands are expressed in the three germ layers of hemichordate embryos in distinct dorsoventral domains, such as pox neuro, pituitary homeobox, distalless, and tbx2/3 on the Bmp side and netrin, mnx, mox, and single-minded on the Chordin-Admp side.

gene nomenclature is beyond useless. there is absolutely no system to these acronyms and they range from inscrutable to downright misleading

[leedsomics]

Single cell transcriptomics uncovers a non-autonomous Tbx1-dependent genetic program controlling cardiac neural crest cell deployment and progression

Disruption of cardiac neural crest cells (CNCCs) results in congenital heart disease, yet we do not understand the cell fate dynamics as these cells differentiate to vascular smooth muscle cells. Here we utilized single-cell RNA-sequencing of NCCs from the pharyngeal apparatus with heart in control mouse embryos and when Tbx1, the gene for 22q11.2 deletion syndrome, is inactivated. We uncovered three dynamic transitions of pharyngeal NCCs expressing Tbx2 and Tbx3 through differentiated CNCCs expressing cardiac transcription factors with smooth muscle genes, and that these transitions are altered non-autonomously by loss of Tbx1. Further, inactivation of Tbx2 and Tbx3 in early CNCCs resulted in aortic arch branching defects due to failed smooth muscle differentiation. Loss of Tbx1 interrupted mesoderm to CNCC cell-cell communication with upregulation of BMP signaling with reduced MAPK signaling and failed dynamic transitions of CNCCs leading to disruption of aortic arch artery formation and cardiac outflow tract septation. http://dlvr.it/SVwMQq

[textbookstobucks-blog]

Philosophy majors stand up! #college #university #school #collegelife #campus #campuslife #springbreak #springbreak2017 #frat #fraternity #sorority #alphaphialpha #deltagamma #deltazeta #kappadelta #zetaphibeta #TBTB #TBX2

[theapprof]

Are You a Warm Demander? | TAPP 115

We once again revisit deadline extensions, we discuss warm demanders and how they avoid toxic rigor, we discover which arm is best for a vaccine booster, we find out if we can grow new auditory hair cells, we get tips on how to speak more effectively while wearing a mask, and learn about a new discovery about oxygen absorption in the intestines.  Can we breathe through our anus? Listen to find out!

00:00 | Introduction

01:02 | Growing New Auditory Hair Cells

06:19 | Mask Talk: Loud, Slow, & Clear

11:17 | Sponsored by AAA

12:21 | Which Arm for That Booster?

15:32 | Intestinal Breathing

19:40 | Sponsored by HAPI

21:03 | Deadlines, Death, and Due Dates

34:31 | Sponsored by HAPS

35:39 | Are You a Warm Demander?

50:08 | Staying Connected

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[Warm demanders] expect a great deal of their students, convince them of their own brilliance, and help them to reach their potential in a disciplined and structured environment. (Lisa Delpit)

  Growing New Auditory Hair Cells

5.5 minutes

An optimistic headline suggesting that we can now cure neural hearing loss turns out to be less than Kevin expected. But still pretty cool. We are poised for a cure!

★ New tool to create hearing cells lost in aging (press release with subtitle, "'We have overcome a major hurdle' to restore hearing") AandP.info/v8i

★ Tbx2 is a master regulator of inner versus outer hair cell differentiation (research article in Nature) AandP.info/md7

  Mask Talk: Loud, Slow, & Clear

5 minutes

As the academic conference season gets into full swing, we may find ourselves trying to communicate while wearing masks. I hope everyone will be wearing masks—except in online conferences.  Kevin's experience in trying to hear conversations while hearing-impaired provides a few tips on effective communications while masked.

★ Let's Talk (Kevin's column in The Academic Author about tips on communicating while wearing a mask; Issue 2022:1) AandP.info/b1c

  Sponsored by AAA

61 seconds

A searchable transcript for this episode, as well as the captioned audiogram of this episode, are sponsored by the American Association for Anatomy (AAA) at anatomy.org.

Searchable transcript

Captioned audiogram 

Don't forget—HAPS members get a deep discount on AAA membership!

  Which Arm for That Booster?

3 minutes

Which arm is best to get that vaccination booster? New evidence suggests that it's the same arm where you received your primary vaccination. Listen and find out the logic behind this strategy!

★ Recall of B cell memory depends on relative locations of prime and boost immunization (research article in Science Immunology) AandP.info/mf6

★ Revisiting A&P Learning Outcomes | Episode 54 (includes segment on recent research on the best time of day to get vaccinated)

  Intestinal Breathing

4 minutes

Apparently mammals can absorb oxygen through the intestinal lining.  At least that's what recent research shows. This could be a breakthrough for oxygenating blood in patients that cannot be artificially ventilated in other ways. But it's just kinda weird, isn't it?

★ Mammals can breathe through their intestines (news article in Science) AandP.info/ruv

★ Mammalian enteral ventilation ameliorates respiratory failure (research report in Med) AandP.info/7pq

★ "Blowing Smoke Up Your @$$" Used to Be Literal (you're probably better off not reading this because you might feel the urge to tell this story in your class) AandP.info/oo2

  Sponsored by HAPI Online Graduate Program

79 seconds

The Master of Science in Human Anatomy & Physiology Instruction—the MS-HAPI—is a graduate program for A&P teachers, especially for those who already have a graduate/professional degree. A combination of science courses (enough to qualify you to teach at the college level) and courses in contemporary instructional practice, this program helps you be your best in both on-campus and remote teaching. Kevin Patton is a faculty member in this program at Northeast College of Health Sciences. Check it out!

northeastcollege.edu/hapi

  Deadlines, Death, and Due Dates

13.5 minutes

Jerry Anzalone calls in with some thoughts on our previous discussion of extending student deadlines. And he even provides a Word Dissection of the term deadline, which turns out to be deadlier than we thought! Jerry suggests an alternative term (and why we may want one) and Kevin shares another alternative used by his friend Wendy Riggs. 

  ★ Should We Extend Deadlines? | Models & Color Codes | TAPP 112 (episode where I start this conversation)

★ Skin's Microbiome & Other Stories | TAPP 114 (episode where Heather Armbruster shares some stories about deadline extensions)

★ Your 'Deadline' Won't Kill You (article from Merriam-Webster about the origins of the term deadline quoted by Jerry Anzalone in his Word Dissection) AandP.info/ank

★ Creating Community in Online STEM Classes (online presentation by Wendy Riggs; one of her many "must see" presentations) AandP.info/cjm

★ Why deadlines are important (you can link to this blog post in The A&P Student for your own students) AandP.info/why-deadlines-c16997

★ Free Parking (I dug up this old 2005 version of my Free Parking handout and it's now available as a bonus PDF on the TAPPapp (The A&P Professor listening app) theAPprofessor.org/tappapp or search in your device's app store [free]

  Sponsored by HAPS

64 seconds

The Human Anatomy & Physiology Society (HAPS) is a sponsor of this podcast.  You can help appreciate their support by clicking the link below and checking out the many resources and benefits found there. Watch for virtual town hall meetings and upcoming regional meetings!

Anatomy & Physiology Society

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  Are You a Warm Demander?

14.5 minutes

Kevin shares a term new to him (but not to others)—warm demander. What is a warm demander? Is it something to avoid or aspire to? How does the term compare to toxic rigor?

★ Becoming a Warm Demander (article from ACSD summarizes some important points) AandP.info/b1j

★ The Teacher as Warm Demander (another good article from ACSD) AandP.info/iql

★ "Multiplication Is for White People": Raising Expectations for Other People’'s Children (book by Lisa Delpit) geni.us/IvXM0C

★ Humanizing Online STEM (home page of the program Kevin describes in this segment: "Instructor-student relationships are the connective tissue between students, engagement, and learning… face-to-face and online") AandP.info/ue4

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★ Transcript available in the transcript box: theAPprofessor.org/podcast-episode-115.html

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Check out notes and transcript for this episode!

[indianfitnesscare]

Scientists Discover Master Gene That Restores Hearing Loss

Scientists Discover Master Gene That Restores Hearing Loss

“It will provide a previously unavailable tool to make an inner or outer hair cell. We have overcome a major hurdle,” Garcia-Anoveros added. In the paper published in the journal Nature, the team described the master gene switch – TBX2. When the gene is expressed, the cell becomes an inner hair cell. When the gene is blocked, the cell becomes an outer hair cell. The ability to produce one of…

[guitarquest]

This leads into tunable analog synths. I contacted Tone Tweakers per advice from a pianist I know, and they said they have two completely analog new synths you can tune, the Monolouge (only can play one note at a time) and the Minilogue (polyphonic up to 4 notes with a firmware upgrade they could do). But they didn’t’ answer my request for info on how the “microtuning” works. Online I found it saying you can only tune 12 notes and only up to 49 cents off A440 equal temperament. I can’t fit my ancient 12 tone just intonation tuning on that as my A is at 432 and my F note ends up being over 60 cents off standard equal temperament. Why would they support microtuning that only changes notes by 50 cents?? Wacko.

Btw there’s a newer version of the Minilouge, looks like it’s not true pure analog. And there’s the DeepMind 12d that comes up as being another low priced analog synth but I found a website saying it’s actually an analog digital hybrid.

So this leads into the idea of using software or hardware to override the tuning of a synth to make it microtonal. Jeff aka Jahloon, creator of this forum and website, speaks very favorably of h-pi instrument’s Tuning Box, later called TBX1, and now TBX2, and has an article here on it. It is hardware designed to retune synths to anything you want. Aaron, creator of h-pi, had sold me the software I used with my PC to override the tuning on my digital piano to make it microtonal to make most of my youtube vids. For the money it was a very good deal. I had problems Aaron says were due to Microsoft updates, and I think he’s right. I will never buy Microsoft products again. I just contacted Aaron for advice and he told me he’s designed a new streamlined product, much simpler than the TBX2, for like 16 to 32 tunings I think he said, that will control one synth. But it won’t be out for a while.

Bell Tone Synthworks had also informed me of a product that I think may be similar to the Tuning Box, by Tubbutec in Germany, called utune. They have a dealer in California. Aaron is also based in Germany these days.

[cancersfakianakis1]

A genome-wide comprehensive analysis of alterations in driver genes in non-small-cell lung cancer

Lung cancer is one of the most common malignancies and the leading cause of cancer-related deaths worldwide. Although many oncogenes and tumor suppressors have been uncovered in the past decades, the pathogenesis and mechanisms of lung tumorigenesis and progression are unclear. The advancement of high-throughput sequencing technique and bioinformatics methods has led to the discovery of some unknown important protein-coding genes or noncoding RNAs in human cancers. In this study, we tried to identify and validate lung cancer driver genes to facilitate the diagnosis and individualized treatment of patients with this disease. To analyze distinct gene profile in lung cancer, the RNA sequencing data from TCGA and microarray data from Gene Expression Omnibus were used. Then, shRNA-pooled screen data and CRISPR-Cas9-based screen data in lung cancer cells were used to validate the functional roles of identified genes. We found that thousands of gene expression patterns are altered in lung cancer, and genomic alterations contribute to the dysregulation of these genes. Furthermore, we identified some potential lung cancer driver genes, such as TBX2, MCM4, SLC2A1, BIRC5, and CDC20, whose expression is significantly upregulated in lung cancer, and the copy number of these genes is amplified in the genome of patients with lung cancer. More importantly, overexpression of these genes is associated with poorer survival of patients with lung cancer, and knockdown or knockout of these genes results in decreased cell proliferation in lung cancer cells. Taken together, the genomewide comprehensive analysis combined with screen data analyses may provide a valuable help for identifying cancer driver genes for diagnosis and prevention of patients with lung cancer. http://ift.tt/2BVnUEn

[scttsdkeri]

Yesterday my sweet 2nd daughter stopped by 2 surprise us. Got 2 have lunch w/almost all my baby's: TBx2, PB, BB &… https://t.co/epszElrKbq

Yesterday my sweet 2nd daughter stopped by 2 surprise us. Got 2 have lunch w/almost all my baby's: TBx2, PB, BB & me. Missing WR & GBaby BB http://pic.twitter.com/uRyh5g3nB1

— Keri P. Blaker (@keri_blaker) February 9, 2017

via Twitter https://twitter.com/keri_blaker February 09, 2017 at 05:47AM

[tedbearbelly]

This was way funnier in my head when I was drawing this at 2 am. If ya get it, ya get it.

[tedbearbelly]

Get you a man who can do both!

Had a blast drawing the short king, might do more.

[tedbearbelly]

The real question is who will win said staring contest?

So glad these two dapper bois got me outta my art block, hope y’all enjoy!

[tedbearbelly]

THESE TWO WERE ROBBED.

[tedbearbelly]

In celebration of episode 2 (which was spectacular btw) I drew the purple prolapse. Jax’s one liners were everything in this ep. Congrats and thank you @gooseworx and Glitch Team!

Here’s a trippy version:

[tedbearbelly]

Who else is ready to see this purple asshole again?

[tedbearbelly]

WHO’S THAT POKÉMON??????

This was supposed to be posted last Halloween but life shiz happened and had to be placed on the back burner until today! Hope y’all like it!