#testing7

[osazuwaakonedonewsn]

Test7

Testing7: Residents in Zamfara state, one of the troubled states in Nigeria with frequent attacks on the locals by bandits have reported that not less than 20 Vigilantes were killed apparently in error by the Nigerian Air Force fighter jet on Saturday when a group of vigilante members gave a chase to invading bandits who killed and abducted alot of persons most especially farmers at Garin Mani,…

[ivana-uxui]

Evaluation from the heuristic test

Final score: 39/40 =97.5% (38 Green, 2 Orange)

Orange Marks

If pop-up windows are used to display error messages, do they allow the user to see the field in error?

No – there isn’t room for this in the app as most of it is free-form typing. However this can be useful for the log in and sign in screens. Quite possibly when entering times for reminders and events too?

To signal an input error in a form, mark the textbox that needs to be changed

Not designed, but this could be useful for the sign up and log in forms. Quite possibly when entering times for reminders and events too?

Summary:

A lot of what I could improve mention pointing out errors - which I haven’t designed for. The most immediate thing I can think of to implement this is for the form (signing up and logging in). However, this did make me think of use/misuse cases which I havent really had time to look at. 

Heuristic tests don’t really put in consideration the user group and the context, so it gets a bit challenging when trying to think of how usable this app is with its users.

Things to work on:

Refining final designs

And if I have time to add on to my agenda:

Misuse cases for each task (invalid entries, undesirable moods, too many reminders)

Experienced users and how they would use each task (lots of entries, moods, etc)

[tommyru]

Advancement of non-invasive prenatal screening (NIPT) screening

https://en.genomics.cn/en-medical-Prepregnancys.html

Prenatal screening for aneuploidy has altered considerably considering that the 1970s. Non-invasive techniques established in the 1980s and 1990s, incorporated dimensions of maternal serum analytes as well as ultrasonography. The issue with those techniques was not just a high false-negative price of 12% to 23%, a high favorable price of 5% and also a bad sensitivity, varying from 50% to 95% 1. Uncertain results regularly resulted in invasive treatments such as amniocentesis or chorionic villi tasting to carry out karyotyping on fetal samples. Both of those procedures bring a risk of losing the unborn baby.

The exploration of fetal cells in 19792 and fetal DNA in mother's blood in 19973 were key to the growth of a different screening method utilizing cell-free fetal DNA (cfDNA) for non-invasive prenatal testing (NIPT). Nevertheless, it took up until 2008 to demonstrate that trisomy can be determined in mother's blood by utilizing next-generation sequencing (NGS) 4,5. This opened-up a race to create the best NIPT tests making use of NGS to provide as a much more precise as well as more secure approach aiming to stay clear of intrusive test follow up.

NIPT Approach

Recognition of extra fetal chromosomes in mother's plasma was originally approached by utilizing enormous parallel shotgun sequencing (MPSS) techniques integrated with chromosome checking. As the technique enhances all the chromosomes, it struggles with variant in amplification performance throughout the genome. This causes variability of aneuploidy detection for different chromosomes. Counting of the chromosomes is detecting a difference in the quantity of fetal vs maternal cfDNA. This difference boosts with higher levels of fetal portion in cfDNA.

In order to lower redundancy in amplification, targeted sequencing approaches were established for NIPT. This lowered the variety of examined reviews, improved efficiency of analysis and raised level of sensitivity. Incorporating targeted sequencing with SNP evaluation permitted distinction between maternal and also fetal DNA in an example. A further push for improved performance of NIPT techniques is a change to pair-end whole-genome sequencing, which permits distinction of maternal and fetal cfDNA based on piece dimensions. In addition to lowering the required depth of sequencing by two thirds, it is claimed to be much less conscious fetal fraction to return a legitimate outcome.

The NGS-based approaches have been utilized by NIPT laboratories considering that 2011 and regardless of a decrease in NGS expenses, NIPT implementation is still expensive. Nevertheless, the cost of the examinations in established countries has actually improved, specifically with boosted coverage of tests by medical insurance. Nevertheless, the market in creating countries is much more price-sensitive and also some business are actively working with and also launching cheaper choices. A Swedish firm, Vanadis, presently part of PerkinElmer uses a rolling circle boosting on its platform6. A Cyprus based startup, NIPD Genetics Ltd, patented a methylation-based MeDIP qPCR method for spotting aneuploidies. As well as Bio-Rad revealed that it works on the electronic PCR variation for NIPT testing7. We will likely see further innovation advancement driving the top quality of examinations up and costs down.

NIPT examination landscape

Adhering to the early documents, several companies started servicing NIPT tests and rapidly, within two years 7 tests were launched. The area came to be even more crowded in the following few years with extra examinations being established and also launched.

2011-- Sequenome releases MaterniT21 And also

2011-- BGI introduces NIFTY

2011-- Berry Genomics launches BambniTest

2012-- Verinata Wellness introduces Verifi examination

2012-- Ariosa Diagnostics launches Harmony examination

2012-- LifeCodexx releases PrenaTest

2012 - Natera launches View test

2014-- LabCorp introduces InformaSeq

2014-- Sequenome introduces VisibiliT-- for average-risk maternities

2015 - Pursuit releases Q-natal Advanced

2017-- Illumina launches VeriSeq NIPT remedy

2018-- PerkinElmer introduces CE-IVD mark for its NIPT Vanadis option

While this checklist catches the primary tests, new tests are being developed continually as well as old examinations being boosted. Furthermore, there has actually been a dramatic increase in a number of laboratories supplying NIPT tests, either accredited from the companies which developed them or developed as LDTs.

Fostering of NIPT in professional technique

NIPT testing was originally targeted at ladies at increased danger of aneuploid maternities. These were ladies over the age of 35 or those who formerly had a trisomy child. The main ACOG recommendations in 2013 were that NIPT should be provided just to ladies within a risky group since inadequate assessments were performed in low-risk group8. Within 4 years, in 2016, ACOG released new suggestions stating that NIPT must currently be supplied to all expectant ladies. In 2016, ACOG recommends:

" Informing all pregnant women that NIPS is one of the most delicate testing option for generally evaluated aneuploidies (i.e., Patau, Edwards, and also Down disorders)" 1.

The factor for the modification was professional energy tests comparing NIPT as well as traditional screening approaches for women in standard- as well as high-risk groups. Information has actually demonstrated that NIPT is superior to the standard testing technique in low-risk females not simply in the risky group. The researches concentrated on the three most usual trisomies: chromosome 21 (Down Syndrome), 18 (Edwards Syndrome) and 13 (Patau's Disorder). This unlocked for a much larger fostering of NIPT.

What is required to execute NIPT tests?

Execution of NIPT examinations raises globally. While some tests are still mainly performed by a couple of central laboratories, others are being embraced by service laboratories and also smaller sized centers. Independent of the size, the labs have to be certain of their ability to determine trisomies reliably. Some of the ACOG guidelines connecting to screening itself consist of the complying with 1:

" Laboratories ought to supply readily noticeable and also clearly mentioned discovery rate (DR), clinical uniqueness (SPECIFICATION), favorable anticipating value (PPV), and negative predictive value (NPV) for problems being screened, in pretest advertising and marketing products, as well as when reporting laboratory results to aid clients and companies in making decisions as well as translating results.

Laboratories should not supply to evaluate for Patau, Edwards, as well as Down syndromes if they can not report DR, SPECIFICATION, and also PPV for these conditions

All research laboratories should include a clearly noticeable fetal portion on NIPS reports.

All labs need to develop as well as keep an eye on logical and also professional legitimacy for the fetal fraction.

All laboratories must define the factor for a no-call when reporting NIPS results"

How can your lab follow these standards?

The most basic approach is to use ideal NIPT referral products, which will certainly permit you to report DR, SPEC, PPV, and NPV for each examination. Such recommendation materials will certainly additionally aid you establish that each reported result is within the variety developed in your lab as well as its fetal fraction is above the detection cut-off.

Click to know more about BGI prenatal test products if you are interested.

BGI China has an experienced medical team of genetic counsellors that can aid understand your risk for sure genetic diseases. Don't wait to call us in case you need more info.

[gasguide38]

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[gccmarketing]

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[ivana-uxui]

Testing and prototyping #7

Define the goals:

Hypothesis:

I should have a heuristic score of over 80% due to all the iterations I have gone through.

Concerns

The heuristic test obviously won’t emulate user behaviour and actions.

Areas Of Interest

The system as a whole and how it tests through an expert’s eye

Purpose

Testing the whole app as a whole with the main flows.

Compare this to the first iteration, and hopefully there is an improvement

Format and setting

I will do this myself, as the expert of the application with a set list of heuristics.

Tasks

There are tasks which hit the main flows of the application

Gestures are limited to a tap due to the low-fidelity prototype

Includes sign up all the way up through each section of the apps

Collecting metrics

To run the heuristic test, there is a set list revised by Gomez.

I think that it needs to have a score over 80% to pass the heuristic test, especially after all the iterations.

[ivana-uxui]

Prototype #7

Here is the flow and the screens for the 7th iteration that I will put through the heuristic test. I didn’t do animations due to a lack of time, but I feel like I understand the animations enough to not do it for a heuristic test.