#tlr7

[j3rryth0mp50n]

Range Ready 💪 #t5customkydex #t5militia #g45 #g19 #streamlight #tlr7 #tlr7a #holsterdaddy #getoutandtrain #vikingbeard #valkyrie #norseman #blackflag #shoplife #rangeday https://www.instagram.com/p/Cl7hHNMLHzx/?igshid=NGJjMDIxMWI=

[unification]

i need to stop reading ruhnama right now and do my presentation on X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19

[recoiloperated]

Question you might be able to help with. I’m looking for a weapon light for my CCW. Do you have any opinions on them and if so, is going for the cheap 80 dollar one at the surplus store a smart option, or go for the stream light TLR7 on sale for 160?

The only weapon lights really worth purchasing is streamlight or surefire. My $20 convoy handheld light might be briefly somewhat competitive with my $300 HRT AWLS, however, my AWLS maintains it's brightness and throw essentially indefinitely. My S6 is only good for max output for about 35 seconds

[chrisgunman]

Sorry for the Autist post but here's the new P365 Macro frame (Converted from and XL)

Photos: XL w/Macro mag, Macro frame w/mag, XL w/Macro mag and XL extended baseplate, Macro/XL mag.

P365 Macro frame showed up today.

General thoughts are all positive. It's only a little thicker, in a good way. If you can carry a compact like a P10C or G19 then this will be about the same in length, but is still noticeably thinner overall.

Capacity bumps to 17rds (from 12 in the X/XL) and seems shorter than the older 15rd mag, and it ships with 3 baseplates. One for the Macro, one for the X/XL, and one for a micro frame.

Heads up for those than are keen-eyed, I have the wrong clamp installed on the light in the macro picture (the Macro has a 1913 rail). If you have a TLR7 Sub, send Streamlight a parts request for whatever rail adapter you need and they will send you one for free. Got mine today, just didn't install it for pictures.

[evcryopeneye]

Get to know the mun

what’s your phone wallpaper :  the family cat last song you listened to : Godless - Kangacurrently reading : "The Toll for Trafficking: Toll-Like Receptor 7 Delivery to the Endosome" A review paper on TLR7 transport because I am at work.... last movie : Guardians of the Galaxy Vol. 3 last show : Fire County what are you wearing right now : Jeans and a Cvhrches T shirt piercings / tattoos? : 6 piercings, 4 tattoos. glasses ? contacts? : neither last thing you ate? : Coffee favorite color(s) : pastel purple, silver, pastel pink, grey. current obsession :  the new Babymetal album do you have a crush right now? : I aint got time for that. favourite fictional character : *points at the muse list*

tagged by: @transcendcnce & @fasciinating tagging: whoever, do it if you want.

[wimpydave]

The Best Light For Your Glock 43X MOS | Streamlight TLR7 Sub

[darkmaga-retard]

What are the ingredients and contaminants that caused so many Adverse Reactions?

GeoffPainPhD

Sep 24, 2024

I have only mentioned the Indian Covid19 Jab Covaxin in passing while discussing mechanisms of jab menstrual problems1, so now is the time to delve further.

Maryanne Demasi told us about pressure to retract a prospective study in India.2

Covaxin contains 6μg whole-virion β-propiolactone inactivated Coronavirus strain NIV-2020-770, Aluminum Hydroxide gel (250 μg), TLR 7/8 agonist (Imidazoquinolinone) 15 μg, 2-Phenoxyethanol 2.5 mg, and Phosphate buffered Saline.

TLR Hitting is not a great idea.3

Case Reports of Covaxin Damage

As discussed in numerous articles, Case Reports are the best source of information on Jab Harms. There were initially numerous Skin damage reports.45

Here is a man who suffered greatly 3 days after his first dose of Covaxin.6

The article also includes a photo of his damaged penis.

In 2021 Herpes Zoster reactivation was reported by doctors in Ethiopia with a call to monitor more jabbees.7 Read more on this common Jab Harm8 and the known Endotoxin link.9

Two cases of Autoimmune Kidney damage were reported in Chennai, India.10

Heart attack just 12 hours after first Covaxin Jab in previously fit 29-year-old man.11

Psoriasis Flare-Up in a 21-year-old man 4 days after his Covaxin Jab.12

Asymmetrical cutaneous vasculitis suffered by a 31‐year‐old woman 4 days after her Covaxin jab.13

Further severe Skin Rash in a 48-year-old woman one day after her Covaxin jab.14

Survey finds more Covaxin Skin disease.15

Vitiglio from Covaxin.16 See also my earlier article on Edotoxin causing Vitiglio.17

Acute Psychosis in a 17-year-old girl.18

Seizure following the administration of Covaxin.19

Facial nerve palsy after second Covaxin jab.20

TLR7 ad TLR8 diseases

Covaxin jab designers boast about deliberate targeting of TLR7 and TLR8.

US Government Comparative Toxicogenomics Database has 1,375 line entries and thousands of references for Diseases that will be caused by hitting your TLR7 and TLR8.21

Here is their summary chart showing more Human Curation is needed, but note Cancer, Skin, Immune System and Nervous System diseases are prominent.

[ribosome-papers]

2'-O-Methyl-guanosine 3-base RNA fragments mediate essential natural TLR7/8 antagonism

bioRxiv: http://dlvr.it/TB4RpW

[reportsofawartime]

molbio08

@molbio08

この問題の本質はシュードウリジン化したｍRNAを用いることにあります。ｍRNAワクチンではなぜｍRNAをシュードウリジン化しなければならいのか。それは細胞が備えている外来のDNAやRNAを検出するセンサーに関連しています。細胞にとっては細胞の機能を乗っ取られてしまうウイルスの進入は一大事です。ウイルスは細胞の機能を利用して勝手に増殖して細胞を破壊してしまうからです。 ファイザーとモデルナのｍRNA型ワクチンではウリジン全てシュードウリジンに置換されています。シュードウリジン化することの目的は細胞内の外来の核酸が侵入してきたときに感知して反応するセンサーが反応しなくなるようにすることでした。トル様受容体という受容体が細胞膜とか、あるいは細胞内小胞（エンドソーム）の膜に存在しています。このうち、TLR3,TLR7.TLR9は細胞内のエンドソームの膜に配置されており、TLR3は細胞内の二本鎖RNAに対して反応し、TLR7は一本鎖RNAに、TLR9はDNAに反応します。 これらの受容体は細胞内にウイルスが侵入したことを察知し、一連のサイトカインの分泌を促し感染細胞を殺す反応を誘導します。このような現象を招かないようにすることを目的としてmRNA型ワクチンではウリジンをシュードウリジン化しています。細胞内で翻訳反応において重要な機能を担っているｔRNA（トランスファーRNA）の」ウリジンはシュードウリジン化されており、TLRが反応しないようになっています。 mRNAワクチンでウリジンをシュードウリジン化しておくことにより、ｍRNA導入細胞が免疫システムで殺傷されないようにしているわけです。mRNAワクチンで使用しているのは左側の1－メチルシュードウリジンです。

[rnomics]

Animals, Vol. 13, Pages 1667: Comparative Transcriptome Analysis Reveals the Innate Immune Response to Mycoplasma gallisepticum Infection in Chicken Embryos and Newly Hatched Chicks

Mycoplasma gallisepticum (MG) is a major cause of chronic respiratory diseases in chickens, with both horizontal and vertical transmission modes and varying degrees of impact on different ages. The innate immune response is crucial in resisting MG infection. Therefore, this study aimed to investigate the innate immune response of chicken embryos and newly hatched chicks to MG infection using comparative #RNA-seq analysis. We found that MG infection caused weight loss and immune damage in both chicken embryos and chicks. Transcriptome sequencing analysis revealed that infected chicken embryos had a stronger immune response than chicks, as evidenced by the higher number of differentially expressed genes associated with innate immunity and inflammation. Toll-like receptor and cytokine-mediated pathways were the primary immune response pathways in both embryos and chicks. Furthermore, TLR7 signaling may play an essential role in the innate immune response to MG infection. Overall, this study sheds light on the development of innate immunity to MG infection in chickens and can help in devising disease control strategies. https://www.mdpi.com/2076-2615/13/10/1667?utm_source=dlvr.it&utm_medium=tumblr

[alphakoncepts]

New EDC. Product reviews soon... M&P 2.0, TLR7, Holosun EPS, C&G Holster

[didanawisgi]

 On activation of the downstream signaling, the body will recognize and responds to viral RNAs. This recognition of single and double-stranded RNA is by endosomal receptors such as Toll-like receptors (TLR3), TLR7, and TLR8. Double-stranded and 5′-triphosphate modified RNA is recognized by the cytosolic receptor’s retinoic acid-inducible gene-I (RIG-1) and melanoma differentiation-associated protein 5 (MDA-5). Allergic reactions and anaphylactic shock were reported when the body’s immune system is activated in an uncontrolled manner. This overstimulation of the immune system on a molecular level will limit the protein translation, expression of antigens, and vaccine efficacy. This limitation can be overcome by nucleobase modifications. N1-methylpseudouridin, a modified nucleobase, will increase the protein output and decrease the activation of TLR3. Modified nucleotides through RIG-1 not only affect protein-RNA interaction but also decrease the ability of mRNAs to disseminate immunological signals. Translation efficiency of mRNA into protein is improved because of N1-methylpseudouridin.

[healthpulsetoday]

Role of TLR7/8 Agonists in Treating Various Cancers

Toll-like receptors (TLRs) are essential components of the immune system, responsible for recognizing and responding to pathogens. Among these receptors, TLR7 and TLR8 play a crucial role in regulating the immune response to viral infections. Recently, researchers have found that TLR7/8 agonists have the potential to treat various cancers. In this blog, we will explore the role of TLR7/8 agonists in treating cancer, immune disorders, and the latest research and development in this domain.

[tumimmtxpapers]

Engineering kinetics of TLR7/8 agonist release from bottlebrush prodrugs enables tumor-focused immune stimulation

Imidazoquinolines (IMDs), such as resiquimod (R848), are of great interest as potential cancer immunotherapies because of their ability to activate Toll-like receptor 7 (TLR7) and/or TLR8 on innate immune cells. Nevertheless, intravenous administration of IMDs causes severe immune-related toxicities, and attempts to improve their tissue-selective exposure while minimizing acute systemic inflammation have proven difficult. Here, using a library of R848 "bottlebrush prodrugs" (BPDs) that differ... http://dlvr.it/SmrxzJ

[peertechz]

Different roles of sex hormones in inflammation may lead to sex-disaggregation of COVID-19 pathology

Severe acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2), the single strain RNA virus, infection causes the global pandemic coronavirus disease 2019 (COVID‐19), in which the immune escape ability of SARS‐CoV‐2 has an important role by inhibiting antiviral innate immunity. Pattern-Recognition Receptors (PRRs), such as Retinoic acid-Inducible Gene I (RIG-I), induce antiviral innate immune responses by sensing viral nucleotides and producing type I interferons. Epidemiological investigation reveals there is sex disaggregation in that males experience more severe symptoms and suffer higher mortality from COVID‐19 than females. This review discusses the different roles of sex hormones in the immune response to SARS‐CoV‐2 infection to explain the mechanism of sex disaggregation and explore novel preventive strategies.

The Pattern-Recognition Receptors (PRRs), including Toll-Like Receptors (TLRs) in the endosome and retinoic acid-inducible (RIG)-1-Like Receptors (RLRs) in the cytoplasm, sense viral infection by binding the RNA of SARS-CoV-2 and induce antiviral innate immunity through producing type I interferons and inflammatory cytokines [1]. Efficient type I interferon production and antiviral immunity will eliminate invading SARS-CoV-2 and block infecting other organs by hematogenous dissemination at the early stage upon infection. On the other side, overactivation of inflammation through nuclear factor κ B (NF-κB) signal pathway with more inflammatory cytokines, such as interleukin 1, 6 and tumor necrosis factor α, will also aggravate infection and multiple organs dysfunction syndrome at the late stage. RIG-I-induced TBK-IRF3 activation was responsible for cytoplasmic viral RNA from the receptor (ACE2) medicated invasion of SARS-CoV-2. Lysosome localized TLR7 was responsible for detecting endosome-lysosome viral RNA from lipid raft medicated invasion of SARS-CoV-2 [1].https://www.peertechzpublications.com/articles/JGRO-9-218.php