#tlr7

[unification]

i need to stop reading ruhnama right now and do my presentation on X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19

[recoiloperated]

Question you might be able to help with. I’m looking for a weapon light for my CCW. Do you have any opinions on them and if so, is going for the cheap 80 dollar one at the surplus store a smart option, or go for the stream light TLR7 on sale for 160?

The only weapon lights really worth purchasing is streamlight or surefire. My $20 convoy handheld light might be briefly somewhat competitive with my $300 HRT AWLS, however, my AWLS maintains it's brightness and throw essentially indefinitely. My S6 is only good for max output for about 35 seconds

[gunsrfunpewpew]

Glock 45

Holosun scs-mos-gr.

Streamlight tlr7

Wph own holster

[ribosome-papers]

2'-O-Methyl-guanosine 3-base RNA fragments mediate essential natural TLR7/8 antagonism

bioRxiv: http://dlvr.it/TB4RpW

[reportsofawartime]

molbio08

@molbio08

この問題の本質はシュードウリジン化したｍRNAを用いることにあります。ｍRNAワクチンではなぜｍRNAをシュードウリジン化しなければならいのか。それは細胞が備えている外来のDNAやRNAを検出するセンサーに関連しています。細胞にとっては細胞の機能を乗っ取られてしまうウイルスの進入は一大事です。ウイルスは細胞の機能を利用して勝手に増殖して細胞を破壊してしまうからです。 ファイザーとモデルナのｍRNA型ワクチンではウリジン全てシュードウリジンに置換されています。シュードウリジン化することの目的は細胞内の外来の核酸が侵入してきたときに感知して反応するセンサーが反応しなくなるようにすることでした。トル様受容体という受容体が細胞膜とか、あるいは細胞内小胞（エンドソーム）の膜に存在しています。このうち、TLR3,TLR7.TLR9は細胞内のエンドソームの膜に配置されており、TLR3は細胞内の二本鎖RNAに対して反応し、TLR7は一本鎖RNAに、TLR9はDNAに反応します。 これらの受容体は細胞内にウイルスが侵入したことを察知し、一連のサイトカインの分泌を促し感染細胞を殺す反応を誘導します。このような現象を招かないようにすることを目的としてmRNA型ワクチンではウリジンをシュードウリジン化しています。細胞内で翻訳反応において重要な機能を担っているｔRNA（トランスファーRNA）の」ウリジンはシュードウリジン化されており、TLRが反応しないようになっています。 mRNAワクチンでウリジンをシュードウリジン化しておくことにより、ｍRNA導入細胞が免疫システムで殺傷されないようにしているわけです。mRNAワクチンで使用しているのは左側の1－メチルシュードウリジンです。

[ar9mm-chan]

My tism kit, really considering that need tlr7 hlx, dropping my sidecar too

Normal EDC.

Jacket weather carry.

[everydaycivilian]

#sundaygunday with the @czusafirearms Bren 2Ms pistol in 7.62x39 and P-10 S OR 9mm ➖➖➖➖➖➖➖➖➖➖➖➖ #everydaycivilian #edc #everydaycarry #czusa #bren2ms #p10s #czp10c #czp10s #czbren2 #762x39 #9mm #gearheadworks #gsltechnology #suppressor #silencer #gslsuppressor #streamlight #tlr7 #trijicon #eotech https://www.instagram.com/p/CgrGjjxLGmR/?igshid=NGJjMDIxMWI=

[j3rryth0mp50n]

Boo! 👻👻👻 #t5customkydex #t5militia #t5ddos #multicam #streamlight #tlr7 #tlr7a #edc #igmilitia #holster #holsterdaddy #polymer80 #pf940v2 #glock34 #2arightsarecivilrights #personaldevelopment #warriormindset #warriormentality #getoutandtrain #goat #vikingbeard #valkyrie #norseman #blackflag #shoplife #usa https://www.instagram.com/p/CaFV3YFrWQR/?utm_medium=tumblr

[returnofarmsnotsigns]

Maybe it's a design flaw. I Wonder if anyone else has that problem with the tlr7

Alright 40 rounds of buckshot and two light strikes. No problems with the last two boxes but I'm still wary.

Also my TL-Racker is starting to flicker. I just hope that's the batteries going out and not the light itself failing.

[didanawisgi]

 On activation of the downstream signaling, the body will recognize and responds to viral RNAs. This recognition of single and double-stranded RNA is by endosomal receptors such as Toll-like receptors (TLR3), TLR7, and TLR8. Double-stranded and 5′-triphosphate modified RNA is recognized by the cytosolic receptor’s retinoic acid-inducible gene-I (RIG-1) and melanoma differentiation-associated protein 5 (MDA-5). Allergic reactions and anaphylactic shock were reported when the body’s immune system is activated in an uncontrolled manner. This overstimulation of the immune system on a molecular level will limit the protein translation, expression of antigens, and vaccine efficacy. This limitation can be overcome by nucleobase modifications. N1-methylpseudouridin, a modified nucleobase, will increase the protein output and decrease the activation of TLR3. Modified nucleotides through RIG-1 not only affect protein-RNA interaction but also decrease the ability of mRNAs to disseminate immunological signals. Translation efficiency of mRNA into protein is improved because of N1-methylpseudouridin.

[pieceofmindguns]

⚡️ Q BLACK ERECTOR 22 SILENCERS⚡️ Live on site! In 📈and ready to 🤘🏼! #pieceofmindguns #pieceofmindco #pieceofmind #liveqordie #unpossible #erector22black #22lr #onceyougoblack #onceyougoblackyounevergoback #silencer #suppressor #taurususa #tx22 #holosun #extendedmag #tandemkross #streamlight #tlr7 #innovateordie #silencershop #utah #utahisrad #utahphotographer #utahgram #utahisbeautiful #getoutside #slc #saltlakecity (at Salt Lake City, Utah) https://www.instagram.com/p/CZ1ZhYlLeZF/?utm_medium=tumblr

[glockguy226]

The Ghost Multicam On This M&P 2.0C Never Gets Old ☠ #MandP #EDC #smithandwesson #gunsdaily #multicam #tlr7 #pewpewlife #apex #customguns #tactical #concealedcarry #9mm https://www.instagram.com/p/CPoxjTShDOH/?utm_medium=tumblr

[everydaycivilian]

The @czusafirearms P-10 S quickly jumped up to the front of the EDC line ➖➖➖➖➖➖➖➖➖➖➖➖➖ #everydaycivilian #edc #everydaycarry #czusa #p10s #p10sOR #concealedcarry #czp10s #streamlight #tlr7 #trijiconrmr #tidwellknifeandtool #firearm #firearms https://www.instagram.com/p/CbBN6unrWNz/?utm_medium=tumblr

[brothersglendaniel]

Keepin’ clean and caffeinated!!! #hoppes9 and proper #guncare are part of #consealedcarry curriculum - join us 🇺🇸 10 October 🇺🇸 DM for details . . . . . #salientarmsinternational #sigsauer #p365 #boresnake #streamlight #tlr7 #glock19 #gunlube (at Wilmington, North Carolina) https://www.instagram.com/p/CFvBUIQpec5/?igshid=ap1zissdp08v

[j3rryth0mp50n]

Sig Saturday 🖤 #t5customkydex #t5militia #t5eoor #multicam #multicamblack #multicamblackgang #trijicon #sigsaturday #sig #xcompact #usa #siglife #streamlight #tlr7 #edc #holster #holsterdaddy #saturdays #personaldevelopment #getoutandtrain #goat #vikingbeard #norseman #valkyrie #warriormindset #warriormentality #blackflag https://www.instagram.com/p/CU1MWFVLaTV/?utm_medium=tumblr