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Testosterone replacement therapy (TRT)

This week we are continuing our mini-series on low testosterone (low T) and testosterone replacement therapy. 

Today we'll cover low T treatment options and the potential side effects of testosterone replacement therapy (TRT). All this and more in less than 5 minutes.

What are some low testosterone treatment options?

If your lab results indicate that your testosterone is low, there are several treatment options available to help increase your testosterone level. This testosterone therapy is called testosterone replacement therapy (TRT). 

TRT involves directly introducing additional testosterone into your system. Options include injections, gels, creams, troches, patches, pellets, and tablets.

Injections are typically given subcutaneously (into the fatty tissue) or intramuscularly (into the muscle), depending on your prescribed product. How often you'll receive the injection depends on the specific product too. 

Creams and gels are applied topically to the skin. Where you apply the cream or gel will depend on the product you have been prescribed. There are nasal gels that are applied inside your nose. These products must be applied 3 times a day, and you can't blow your nose for an hour after using them.

Patches are typically applied to the back, upper arm, or stomach (not a bony area or on the back of your thighs). Patches should be worn for 24 hours, and the old patch should be removed before putting on a new patch. 

Testosterone pellets are surgically implanted typically into the upper hip or buttock. It's also important to know that adjusting your dose is difficult and requires surgery. But these pellets last for 3 to 6 months.

Pills aren't as popular as other TRT because they've been associated with possible liver problems in the past. Still, it's good to know that there are testosterone pills available. 

What are the side effects or risks of TRT?

Potential side effects of TRT may include:

Oily skin or acne

Headache

High blood pressure

Hair loss

Worsening of sleep apnea (a sleeping condition where breathing stops and starts)

May cause prostate gland enlargement (make it difficult to urinate)

Gynecomastia (enlargement of a man's breast tissue)

Increased cholesterol levels

Increased blood sugar levels

Blood clots

Liver damage (prolonged-high-dose use)

How often should you test your testosterone levels?

During TRT, you should test your testosterone levels at least every 90 days (or sooner if you continue to have symptoms of low T during TRT). Clinically, if you're doing well and your doctor agrees that your levels are within good ranges, you'll want to test every six months. 

It's important to remember that high testosterone can be just as dangerous as low testosterone. This is because your body will start to convert excess testosterone into estrogen to help compensate. Too much estrogen in the male body is not a good thing. It can affect your sex drive, cause erectile dysfunction, and cause excess breast tissue to grow. If left untreated, you could put yourself at risk for heart and liver problems. 

Thanks again for listening to The Peptide Podcast. You can find more information at pepties.com. That's peptides without the D. Where we are tying all the peptide information together along with information on low testosterone and testosterone replacement therapy.

We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. Have a happy, healthy week!

Pro Tip

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

Check out this episode!

[thepeptidepodcast]

What is Low T?

This week we are continuing our mini-series on low testosterone and testosterone replacement therapy (or TRT). Today we'll cover what low testosterone (or low T) is. We'll also go over the symptoms of low T, how to test for low T, and the difference between free testosterone (free T) and total testosterone (total T). All this and more in less than 5 minutes.

What is low T?

The American Urological Association (AUA) recommends that testosterone therapy is prescribed only to men who meet the clinical and laboratory definition of testosterone deficiency which is a testosterone level of less than 300 ng/dL. If you feel fine, the low testosterone level itself is not a cause for concern. But the likelihood is that you'll experience symptoms of low T, which means it's time to call your healthcare provider. 

What are the symptoms of low T?

When your testosterone drops below 300 ng/dL, you may experience the following symptoms:

Irritability or sadness

Having trouble focusing or concentrating

Hot flashes

Feeling tired

Losing muscle mass

Hair loss

Low energy during exercise or decreased stamina

Weight gain

Low sex drive

Erectile dysfunction AND

Fertility issues

How can I test for low T?

You should go to a healthcare provider or clinic specializing in hormone evaluation. The provider will take a blood sample and may look at a few different markers in your blood to help determine the next steps for maintaining normal testosterone levels.

It's important to know that not all tests are created equal. Make sure your provider uses a blood test to check your testosterone levels, not a saliva test. Saliva test results aren't as reliable as blood tests tracking hormonal changes. Furthermore, your reference results aren't reproducible. Each saliva test you take will achieve a different result. Also, saliva testing can only measure your free testosterone levels but not your total testosterone levels.

You should fast for 10-12 hours before taking your test, and you must complete your test no later than 10 a.m. According to the AUA, testosterone levels peak in the early morning between 7 a.m. and 10 a.m. and steadily decline throughout the day.

What is the difference between free T and total T?

Most of the testosterone in the body is attached or bound to proteins like sex hormone binding globulin (SHBG) and albumin and moves around your body, bound from place to place. 

Total T measures the amount of attached and free testosterone in your body. Free T isn't bound to anything. Free T is the type of testosterone your body uses. Free T helps you build and maintain muscle mass and decrease body fat. It also helps with mood. 

It turns out that the symptoms you feel from low T aren't just caused by the total amount of testosterone in your blood. The number of free T matters too. You could have normal total T levels but still suffer from symptoms of low T because you have low free T levels. This could be due to high levels of SHBG in your blood.

If your total or free T levels are low, testosterone replacement therapy (TRT) may help. More on this next week.

Thanks for listening! You can find more information at pepties.com. That's peptides without the D. Where we are tying all the peptide information together along with information about low testosterone and testosterone replacement therapy.

We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. Have a happy, healthy week!

  Pro Tip

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

  Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

Check out this episode!

[thepeptidepodcast]

Testosterone

Testosterone is a sex hormone made predominantly in the testicles that helps men develop sexually and physically. Hormones are chemicals that carry messages in your bloodstream to the rest of your body. They tell your body what to do and when to do it.  

But it's important to know that everyone has testosterone. It plays a major role in regulating a number of things in women's bodies too, but we're going to focus on testosterone in the context of the male body.

What does testosterone do in your body?

Testosterone plays a key role in regulating cholesterol, blood sugar, and fat levels. It also helps keep our bones strong, build muscle, boosts sex drive, and promotes body and facial hair growth. It can even affect sperm count and mood.

How does your body make testosterone?

Messages are sent from your brain to your pituitary gland. The pituitary gland sends a message to the testes to make testosterone. A "feedback loop" closely regulates the amount of testosterone in the blood. When testosterone levels rise too high, the brain sends a message to the pituitary gland to lower testosterone production.

What happens to your testosterone levels over time?

As men age, their testosterone levels naturally decrease. Peak testosterone levels happen during puberty. Typically men over 30 begin to experience a gradual decrease in testosterone levels where testosterone production decreases about 1% to 2% each year. In addition to age, lifestyle, environmental factors, and overall health contribute to the natural decline in testosterone levels.

Poor health or underlying medical conditions may contribute to testosterone levels decreasing. This includes things like:

Injury or infection of the testicles

Alcoholism

Obesity

Type 2 diabetes

Certain genetic and autoimmune conditions (e.g., Klinefelter Syndrome, lupus, rheumatoid arthritis)

Tumors of the pituitary gland or hypothalamus

Specific cancer treatments (e.g., chemotherapy, radiation)

Certain medications (e.g., opioids, prednisone)

Plastic-leaching PCBs (polychlorinated biphenyls)- resemble estrogen (found in certain fish, dairy products, and animal fat)

Thanks again for listening! You can find more information at pepties.com. That's peptides without the D. Where we are tying all the peptide information together. 

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. Have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

Check out this episode!

[thepeptidepodcast]

Semax

Today we are talking about Semax and its potential benefits. All this and more in less than 2 minutes. 

What is Semax?

Semax is a lab-made peptide that mimics adrenocorticotropic hormone (ACTH). ACTH is located in your pituitary gland and stimulates your adrenal glands to release cortisol. 

What are the BENEFITS? 

Before you understand the benefits of Semax, we first have to go over cortisol — what it is and how it works in the setting of stress. 

Cortisol is a hormone released into your bloodstream when your body undergoes stress. This hormone causes an increase in your heart rate and blood pressure. It’s your natural “fight or flight” response. However, over time, if your body experiences repeated stress, you may begin to feel tired, irritable, depressed, and even experience weight gain. Cortisol also helps your body break down fats and suppress inflammation. Because of this, Semax is helpful in those people with cardiovascular disease, blood clots, strokes, and inflammation.

If you remember, last week we talked about Selank. Just like Selank, Semax rapidly increases the brain-derived neurotrophic factor (BDNF) levels in the hippocampus. This is important for memory, concentration, and learning. Because of this, Semax is helpful for those with ADHD.

Also, like Selank, Semax is considered a nootropic peptide because it improves cognitive function and memory.

How do I take Semax?

Semax is given as an intranasal (into the nose) spray daily. You should not use more than you’re prescribed dose. Studies suggest doses above the maximum amount can reduce your response to Semax. 

Possible side effects include headaches. Also, since it’s a nasal spray, you may experience a stinging or burning sensation in your nose or an unpleasant taste in your mouth. As always, you should tell your healthcare provider about any side effects you experience. 

You can find more information at pepties.com. That’s peptides without the D. Where we are tying all the peptide therapy information together in one easy place.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. And subscribe to our podcast. Have a happy, healthy week!

Pro Tips

Giving yourself a peptide injection can be scary or confusing. But we’ve got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you’ll need. This may include syringes, needles, alcohol pads, and a sharps container.

We’re huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. They also help with anti-aging. Our favorite collagen peptide powder is Thorne® Collagen Plus. 

Check out this episode!

[thepeptidepodcast]

Selank

Today we are talking about Selank and its potential benefits. All this and more in less than 2 minutes. 

What is Selank?

Selank is a lab-made peptide that was made by combining the naturally occurring peptide tuftsin with another sequence to make it more stable. Tuftsin makes up a large part of the natural antibody IgG. This antibody in our blood helps prevent infections. 

What are the BENEFITS? 

You may hear Selank referred to as the “anti-anxiety” peptide or a “nootropic.” In clinical trials, it has been shown to provide an anti-anxiety effect. It does this by affecting GABA. GABA is an inhibitory neurotransmitter. It slows down your brain by blocking signals in your central nervous system. It produces a calming effect and can reduce stress, improve sleep, and relieve anxiety. Selank works by enhancing the effect of GABA, thus reducing anxiety.

While most traditional anxiety prescription medications can cause bothersome side effects, clinical studies have shown that Selank doesn’t. You should not experience side effects like drowsiness, dependence, or withdrawal symptoms. 

In addition to its anti-anxiety benefits, Selank stabilizes blood enkephalins. Enkephalins are natural peptides found in the brain that help with stress. 

Its nootropic actions improve cognitive function, attention, memory, and motivation. Selank increases the amount of brain-derived neurotrophic factor (BDNF), an important brain growth compound in the hippocampus that helps with learning and memory.

Other studies have shown Selank to increase levels of IL-6, an inflammatory protein in the body that helps fight off infections. It’s also shown to decrease blood sugar and prevention of weight gain. This could be very helpful for those with metabolic syndrome. 

How do I take Selank?

Selank is given as an intranasal (into the nose) spray daily. You should not use more than you’re prescribed dose. Studies suggest doses above the maximum amount can reduce your response to Selank.

Possible side effects include headaches. Also, since it’s a nasal spray, you may experience a stinging or burning sensation in your nose or an unpleasant taste in your mouth. As always, you should tell your healthcare provider about any side effects you experience. 

You can find more information at pepties.com. That’s peptides without the D. Where we are tying all the peptide therapy information together in one easy place.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. And subscribe to our podcast. Have a happy, healthy week!

Pro Tips

Giving yourself a peptide injection can be scary or confusing. But we’ve got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you’ll need. This may include syringes, needles, alcohol pads, and a sharps container.

We’re huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. They also help with anti-aging. Our favorite collagen peptide powder is Thorne® Collagen Plus. 

Check out this episode!

[thepeptidepodcast]

Thymosin beta 4 (TB4 or TB500)

Today we are talking about Thymosin beta 4 (TB4 or TB500) and its potential benefits. All this and more in less than 2 minutes. 

Last week we talked about Thymosin alpha 1 and the importance of the thymus gland and T cells. Before we get into what TB500 is and does, it’s important to know that although it is naturally found in the thymus, TB500 is found in most cells and tissues, except red blood cells. 

What is Thymosin beta 4 (TB4 or TB500)?

TB500 works by binding actin (proteins that makeup 10% of the total proteins in cells). Actin helps with cell division, signaling, and shape. It also speeds up the rate of new tissue growth and new blood vessel formation. This helps wounds heal. It also decreases inflammation and scarring when applied to wounds. 

In the body, T500 levels rise significantly in areas where tissues have been damaged so these areas can be repaired. This is great for those looking to speed up injuries or wounds that are healing slowly. It’s also a good option for chronic injuries that don’t seem to heal quickly.

What are the BENEFITS? 

When we take TB500 as peptide therapy, it’s used for clinical conditions where soft tissue repair, skin, hair growth, and chronic pain management are needed. It’s also been used in people post heart attack to help repair tissue damage and has been clinically shown to improve symptoms of moderate to severe dry eye. 

RGN-259 by RegeneRx Pharmaceuticals is a TB4-based eye drop for dry eye syndrome. It’s currently in Phase II trials in the United States. RGN-352 is a TB4-based injectable drug to prevent and restore heart attack and stroke tissue damage. This medication is currently in Phase II trials.

How do I take TB4/TB500?

TB500 is given as a subcutaneous peptide injection (into the fatty tissue) daily. It’s suggested that this peptide be used no longer than 12 weeks and stopped for at least one month. Studies suggest prolonged use could lead to dependency.

Possible side effects include redness, itching, or swelling at the injection site. Rare cases of tiredness and drowsiness can happen. As always, you should tell your healthcare provider about any side effects you experience. 

You can find more information at pepties.com. That’s peptides without the D. Where we are tying all the peptide information together in one easy place.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. And subscribe to our podcast. Have a happy, healthy week!

Pro Tips

Giving yourself a peptide injection can be scary or confusing. But we’ve got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you’ll need. This may include syringes, needles, alcohol pads, and a sharps container.

We’re huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. They also help with anti-aging. Our favorite collagen peptide powder is Thorne® Collagen Plus. 

Check out this episode!

[thepeptidepodcast]

Thymosin alpha 1 (TA1)

Today we are talking about Thymosin alpha-1 (TA1) and its potential benefits. All this and more in less than 2 minutes. 

Before we get into what TA1 is and does, we need to talk about the thymus gland. Your thymus gland is a small gland located in your upper chest behind your breastbone in the lymphatic system. It makes special white blood cells called T-cells. 

There are two types of T-cells: killer T cells and helper T cells. Both help your immune system fight disease and infection. Killer T cells destroy cancerous cells and cells infected with a virus. Helper T cells work with the other cells of the immune system to make an immune response.

What is Thymosin alpha 1 (TA1)?

TA1 is a peptide that's produced naturally by the thymus gland. As we age, our thymus gland shrinks (atrophies), and this affects the production of TA1. 

In our bodies, TA1 is known as a natural senolytic, which induces the death of aging cells our thymus makes. Taking TA1 as peptide therapy works by mimicking the body's natural release of TA1 in the thymus gland, which stimulates the production of T cells. It also decreases the production of certain proteins called cytokines that can cause chronic inflammatory or immune responses in some people (e.g., chronic fatigue syndrome and fibromyalgia).

Studies have shown that people fighting infection have a lower amount of circulating TA1 than healthy people.

What are the BENEFITS? 

TA1 is used for clinical conditions where immune support is needed. Zadaxin is a TA1 peptide evaluated and approved in 30 countries for treating hepatitis B & C, HIV, and AIDS. It's also used along with chemotherapy for certain lung, liver, and skin cancer patients. In addition, it is used in people with DiGeorge syndrome. Currently, the medication is in Phase III trials for the treatment of hepatitis C and Phase II trials for hepatitis B in the United States. 

Fun fact: TA1 has an Orphan Drug approval by the FDA for several indications. Orphan drugs are medications approved by the FDA for rare conditions that affect fewer than 200,000 people in the U.S.

TA1 has also shown promising results in the treatment of Lyme disease. 

How do I take TA1?

Compared to other peptide therapies, TA1 has a longer half-life of 2 hours, requiring fewer peptide injections. The peptide injection is a subcutaneous injection (injected into the fatty tissue) once every third day. For viral infections, treatments usually last for 2 weeks. But, depending on what you're treating and how serious your infection is, treatment could last 3 months or more.

Possible side effects include redness, itching, or swelling at the injection site. Rare cases of increases in liver enzymes have happened. If you have signs of liver injury (nausea or vomiting, yellowing of the skin or eyes (jaundice), or stomach pain tell your healthcare provider right away. As always, you should tell your healthcare provider about any side effects you experience. 

You can find more information at pepties.com. That's peptides without the D. Where we are tying all the peptide information together in one easy place.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. And subscribe to our podcast. Have a happy, healthy week!

Pro Tips

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. They also help with anti-aging. Our favorite collagen peptide powder is Thorne® Collagen Plus. 

Check out this episode!

[thepeptidepodcast]

Peptide injection tips

Today we are talking about peptide injections. We’ll cover some simple tips to remember before injecting your peptides to help avoid injuries and dosing errors. All this and more in less than 2 minutes. 

Tips to remember before injecting your peptides:

Wash your hands with soap and water before handling your peptides and use an alcohol wipe to clean your injection site and rubber stopper on the top of the peptide vial. This will help prevent skin infections and bacteria from entering into the peptide vial. Allow the alcohol to completely dry on your skin before injecting your peptides. Otherwise, it can sting.

Some peptides need to be refrigerated. While they can be injected cold, that can add to the discomfort of the injection. You can always draw up your peptide dose and set the syringe on the counter for 15-20 minutes to let the peptide solution come to room temperature on its own. Never warm your peptides in a microwave or oven.

Another way to help with injection discomfort is to use ice to numb your skin before your injection. 

If you are dealing with injection anxiety try counting down out loud. Three, two, one, now and then inject! You can also try playing your favorite music in the background.

You can also try to have a peptide injection support person with you or on the phone during your injection. Sometimes having a friend or loved one near you eases anxiety. 

You can always ask your provider if you can give your first injection in their office or over the phone with a nurse. This way you can ask questions and a nurse can walk you through the peptide injection to ease your worries. 

Don’t recap the needle: It’s easy to poke yourself if you try to do this. After injecting, immediately throw away your used syringe into the sharps container. 

Avoid injecting into scars, red or inflamed areas, or moles. This can cause further irritation to these skin areas.

Bleeding may occur after giving a peptide injection. You can use a small cotton ball or a piece of gauze along with light pressure to stop the bleeding. If your bleeding won’t stop or you’re soaking through a cotton ball, call your healthcare provider.

Mistakes can happen, especially if you’re new to giving yourself injections. Call your healthcare provider or clinical pharmacist as soon as possible, and they can tell you what steps to take next if you have questions.

You can find more information on injection techniques at pepties.com.  That’s peptides without the D. Where we are tying all the peptide therapy information together. 

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. We’ll see you next time on The Peptide Podcast. Have a happy, healthy week!

Pro Tips

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. They also help with anti-aging. Our favorite collagen peptide powder is Thorne® Collagen Plus. 

Check out this episode!

[thepeptidepodcast]

How do I give myself a peptide injection?

Today we are talking about peptide injections. We’ll cover the difference between subcutaneous and intramuscular injections, choosing needle length and needle gauge or “thickness”.

Several weeks ago, we talked about WHY we inject most peptides. So now we’ll cover the two common types of peptide injections.

What is the difference between a subcutaneous and intramuscular injection?

Intramuscular peptide injections are given into a muscle that has a blood supply. This allows peptides to be absorbed faster than they would be by the subcutaneous route. Intramuscular injections require a needle around 1 inch long for most adults. The correct needle length is determined by the patient’s size, age, and the amount of fat tissue in the chosen injection site. This length allows the peptides to pass through the different skin and fat layers, but not too long to risk hitting underlying nerves and bone.

The thickness of the needle is measured in millimeters and is referred to as the “gauge .” Needle gauges for intramuscular injections typically range between 22 and 25 gauge. A good way to remember needle thickness is the higher the gauge number, the finer or thinner the needle.

Intramuscular peptide injections should be given so that the needle enters your body at a 90-degree angle. This means it should be a straight injection, not given at an angle. Intramuscular injections are given in the outside of the upper arm, in the hip, in the buttocks, or in the thigh. 

Subcutaneous peptide injections aren’t injected as deep as intramuscular injections. These injections are given in the layer of fat between your skin and muscle. This area is not as richly supplied with blood vessels as your muscles. Peptides given by the subcutaneous route are absorbed more slowly than with intramuscular injections.

Subcutaneous peptide injections require a thinner, shorter needle. Needle gauges for subcutaneous injections typically range between 25 and 31 gauge with needle lengths around ¼ inch to ½ inch long. 

The needle length and needle insertion angle depend on a person’s weight and amount of fatty tissue. Subcutaneous injections can be given so that the needle enters your body at a 45 or 90-degree angle. The needle can be inserted at a 90-degree angle across pinched skin for people with a significant amount of fatty tissue. For those with minimal fatty tissue, the needle should be inserted at a 45-degree angle across pinched skin. 

Subcutaneous injections are given in the back of the upper arm, in your stomach, or in the thigh. Whether you’re giving yourself an intramuscular or subcutaneous injection, remember to try to avoid giving yourself an injection in the same place twice in a row. 

You should always speak to your healthcare provider or pharmacist about which needle length and gauge will work best for your peptide injections. 

As always, you can find more information at pepties.com.  That’s peptides without the D. Where we are tying all the peptide therapy information together. 

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. Leave a comment.. Have a happy, healthy week!

Pro Tips

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. They also help with anti-aging. Our favorite collagen peptide powder is Thorne® Collagen Plus. 

Check out this episode!

[thepeptidepodcast]

How do I draw up peptides into a syringe?

Today we are talking about peptide injections. We’ll cover an easy step-by-step process on how you can draw up your peptides into a syringe so you can easily inject them from the comfort of your home. All this and more in less than 2 minutes. 

Why do we inject peptides?

When it comes to peptide injections, subcutaneous peptide injections or intramuscular peptide injections are the most effective. This is because peptides are easily broken down and destroyed by your stomach enzymes. This means that if you take most peptides orally (by mouth), you may lose most of their benefits because the peptides will be destroyed before they can reach your bloodstream. 

In the beginning, giving yourself a peptide injection at home may seem confusing or difficult. But with some practice, giving yourself a peptide injection can be quick and easy.

Before giving yourself a peptide injection, gather all the supplies you’ll need. This may include syringes, needles, alcohol pads, and a sharps container. Here’s a list of steps to follow:

Wash your hands.

Check your medication. Make sure the medication name on the vial matches the medication name on the prescription label. Make sure the medication isn’t expired. 

If this is your first time using the vial, remove the plastic top. Throw the plastic top away. A rubber stopper will be under the plastic top. Clean the rubber stopper with an alcohol pad.

Keeping the syringe cap on the needle, pull back the plunger on the syringe to add the same amount of air as the dose of your peptide injection into the syringe. For example, if you’re injecting 0.25 mL of Ipamorelin/ CJC 1295, fill the syringe with 0.25 mL of air.

Remove the cap from the needle. Insert the needle into the top of the vial and inject the air. This added air will make it easier to remove the peptides from the vial. Leave the needle in the vial.

Hold the vial with one hand and the syringe with the other hand. Turn the vial and syringe upside down, and draw out the amount needed for your dose. If you accidentally draw up too much, gently push on the plunger to push the liquid back into the vial.

With the needle still in the vial, check for air bubbles inside the syringe. If you see air bubbles, gently tap on the side of the syringe to make the air bubbles rise to the top. Slowly push on the plunger to push the air bubbles into the vial.

Remove the needle from the vial.

  NOW YOU ARE READY TO INJECT YOUR PEPTIDES!!!!

As always, you can find out more information on peptide injections at pepties.com.  That’s peptides without the D. Where we are tying all the peptide therapy information together. 

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. Have a happy, healthy week!

Pro Tips

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. They also help with anti-aging. Our favorite collagen peptide powder is Thorne® Collagen Plus. 

Check out this episode!

[thepeptidepodcast]

Benefits of collagen peptides

Today we are talking about everything collagen peptides! We’ll cover the benefits of collagen peptides, how to take collagen peptides, and potential side effects. All this and more in less than 2 minutes. 

What do collagen peptides do for you?

Let’s face it. Our body changes as we age. And some of these changes, like fine lines and wrinkles, are annoying. But other changes to our bodies can cause serious problems in our daily life. Our bones and muscles may become weaker, affecting our coordination and balance. 

While we haven’t discovered the fountain of youth just yet, some benefits you may receive from collagen peptide therapy can help aging skin, nails, bones, joints and heart health benefits:

Bones:

May help with osteoporosis (condition when bones become weak)

Joints:

Decrease joint pain

May help with osteoarthritis (a condition in which the cartilage and bone in joints of the hands, hips, and knees wear down over time)

Muscles:

May boost muscle mass in aging men

Heart:

May decrease risk for atherosclerosis (when plaque builds up on the walls of your arteries and causes the wall to thicken and harden)

How do I take collagen peptides?

Collagen peptides can be taken with or without food any time during the day. But, it can be hard to know where to start with so many products available. There are powders, capsules, and gummies to liquid shots, and collagen bars to choose from. 

But, finding the right product type can go a long way. You’ll want to use a collagen peptide that’s convenient and works with your lifestyle. Do you like the convenience of swallowing capsules? Would you rather eat your collagen with your meal? 

Collagen powders are versatile and offer a fun way to add collagen to your daily nutrition. The powders are easily added to your favorite hot or cold drink, baked goods, or mixed into your favorite dish (e.g., eggs, oatmeal, yogurt, and baked goods). Make sure to mix a scoop (or two) of your collagen peptide powder while you’re cooking your dish so the powder can dissolve. 

Capsules may seem more convenient, but look at the label and check the dose. How many grams of collagen is in 1 scoop of collagen powder? Compare that to how many capsules you will need to get the same dose. Remember, capsules tend to be on the large side. If you struggle taking pills, this may not be the most fun part of your day.

Liquid shots are pre-measured and ready to drink, so you can skip the mixing or swallowing capsule routine.

The bottom line, the best way to take collagen peptides is what works best for you.

Is it safe to take collagen peptides every day?

Yes. Collagen peptides are generally well tolerated. But, collagen supplements are made from common food allergens such as fish (marine) and eggs (ESM). People with allergies to these foods should avoid these products made with these ingredients. Some people may experience:

Allergic reactions (e.g., skin rash, itching, hives, or swelling of face, throat, lips, or tongue)

You should tell your healthcare provider about any side effects you experience. 

What is the best collagen peptide supplement?

Before you wander down the supplement aisle at your local pharmacy or troll the internet in the thick of all the information (or misinformation) when looking for a collagen peptide supplement, choose products made with hydrolyzed collagen, so it’s easier for your body to digest and absorb the collagen peptides. Make sure the collagen is from grass-fed, hormone-free animals, so you’re using the healthiest, cleanest products. 

Our favorite collagen peptide powder is Thorne® Collagen Plus. 

What We Like:

Gluten free

Dairy free

Soy free

Derived from natural flavors and colors

13 grams of grass-fed, hormone-free collagen per serving (1 scoop)

You can find more information at pepties.com.  That’s peptides without the D. Where we are tying all the peptide information together. 

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast please share it with your friends and family on social media. Have a happy, healthy Friday!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

Check out this episode!

[thepeptidepodcast]

Collagen Peptides

Today we are talking about everything collagen! We’ll cover what collagen peptides are and the different types of collagen. All this and more in less than 2 minutes.

What is collagen?

Simply put, collagen is a protein our bodies use to build and repair tissues. It’s the most abundant protein found naturally in your body. It provides structural support to our skin, blood vessels, and muscles. It is also found in our bones, teeth, and connective tissues (e.g., tendons, ligaments). 

We make less collagen as we age, which affects our skin and our joints. But it can be hard to know where to start with so many products available. So before you buy a collagen supplement, there are some important things we think you should know. 

What are collagen peptides?

The collagen found in supplements isn’t exactly like the collagen found in your body. Collagen peptides are what is known as hydrolyzed collagen. It’s collagen that’s been broken down into smaller parts that are easier to digest and dissolve. 

It’s important to know that our body needs different types of collagen to perform many functions. Our bodies are made up of 28 types of collagen. Most of it is type I, II, or III. 

Type I collagen: Found in your skin, bones, teeth, tendons, ligaments, blood vessels, and eyes. When buying products with Type I collagen- it’s good to know that Type I collagen is commonly sourced from (made from) bovine (cow) or porcine (pig) tissues such as bones, tendons, or lungs. Other sources include marine (fish) tissues such as bone, skin, scales, or chicken bones and eggshell membranes (ESM). 

Type II collagen: Found in your cartilage, the tissue that protects your bones at your joints, your neck, and your spine. When buying products with Type II collagen, keep in mind it’s commonly sourced from chicken cartilage. 

Type III collagen: Found in your muscles and blood vessels. Type III collagen is commonly sourced from bovine tissues.

You can find more information at pepties.com.  That’s peptides without the D. Where we are tying all the peptide information together. 

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. Have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

Check out this episode!

[thepeptidepodcast]

MK-677

Today we are talking about MK-677, what it’s for, and its potential benefits. All this and more in less than 2 minutes. 

What is MK-677?

MK-677 also called Ibutamoren is an ORAL growth hormone-releasing peptide (GHRP) peptide therapy. We’ve talked about these types of peptides before when we discussed Ipamorelin. Unlike Ipamorelin it’s taken by mouth and remains active for about 24 hours. 

MK-677 increases growth hormone levels resulting in increased energy, lean muscle mass and strength, and improved sleep and muscle recovery. 

It can also help decrease body fat by stimulating the production of insulin-like growth factor (or IGF-1). IGF-1 is a hormone that’s similar in molecular structure to insulin and plays an important role in childhood growth and has anabolic effects (or muscle-building effects) in adults. 

MK-677 works by stimulating the pituitary gland to release growth hormone. The body will then increase its own growth hormone production. Over time, the body repairs itself and the aging process is slowed down. 

How to use?

MK-677 is given as an oral tablet by mouth before bedtime or at dinner with a large meal. It’s suggested that this peptide be used no longer than 8 to 12 weeks. Studies suggest prolonged use does not provide continuous release of growth hormone. Further studies are needed.

Possible side effects?

MK-677 also causes an increase in ghrelin, the “hunger hormone”. This hormone is released by the stomach and small intestine and stimulates appetite and promotes fat storage. But this hunger side effect tends to lessen when it’s taken at bedtime or with a large meal.

You should tell your healthcare provider about any side effects you experience. 

You can find more information at pepties.com.  That’s peptides without the D. Where we are tying all the peptide information together in one place.

Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast please share it with your friends and family on social media. Feel free to leave a comment. How have you found peptides to help you? What’s worked for you? What’s not? What have you learned about yourself? And subscribe to our podcast. Have a happy, healthy week!

  Check out this episode!

[thepeptidepodcast]

Epitalon

Today we are talking about Epitalon, what it’s for, and its potential benefits. All this and more in less than 2 minutes. 

What is Epitalon?

Epitalon, is a lab-made version of the polypeptide Epitalamin which is naturally made in the pineal gland in the brain. It’s known for its anti-aging properties, stress reduction, and disease prevention.

What are its benefits?

Epitalon helps slow down the aging process by increasing the natural production of telomerase, a natural enzyme that helps cells to keep multiplying and making telomeres. Telomeres are the protective parts of our DNA, found at the ends of our chromosomes that help keep our chromosomes organized. This, in turn, decreases cell death and extends cell lifespan. 

Epitalon also acts as an antioxidant that eliminates free radicals that are responsible for damaging and killing cells. Free radicals, simply put are unstable atoms that can damage cells, causing illness and aging. In turn, Epitalon plays an important role in helping to suppress cancerous tumor growths.

Epitalon also restores and normalizes melatonin levels in older people who have lost some pineal gland function due to aging. Melatonin is a hormone your brain makes in response to darkness. It helps with sleep and your sleep-wake cycles. This is useful to those looking for more restful sleep.

How do you use this?

Epitalon can be used as a starting therapy to help DNA repair or as an antioxidant. It can also be given as a stand-alone therapy twice a year for cell protection, improving cell resistance, and stopping cell death. Some healthcare providers dose Epitalon intermittently along with other scheduled peptide therapies. The peptide injection is intramuscular (injected into the muscle).

Possible side effects include redness, itching, or swelling at the injection site. You should tell your healthcare provider about any side effects you experience. 

You can find more information at pepties.com.  That’s peptides without the D. Where we are tying all the peptide information together for you in one place.

Check out this episode!

[thepeptidepodcast]

BPC 157

Today we are talking about BPC 157, what it’s for, and its potential benefits. All this and more in less than 2 minutes. 

What is BPC 157? 

BPC 157 or “Body Protection Compound 157” is a lab-made peptide that is a partial copy of human BPC found in stomach acid (gastric juice). 

BPC works by speeding up the rate of the formation of new blood vessels (aka angiogenesis) to help wounds heal. It’s often prescribed to help repair damage caused by inflammation and help improve joint, muscle, ligament, tendon, and bone health.

What are its benefits?

BPC 157 is useful to those looking to help with tendon and ligament healing by increasing the growth of fibroblasts (a type of cells found in connective tissues like bone and cartilage that are involved in making collagen to provide strength to the site of a wound).

It can also help heal stomach ulcers caused by NSAIDs (non-steroidal anti-inflammatory) medications like ibuprofen and naproxen as well as help repair damaged intestinal tissues caused by inflammatory bowel disease. 

How do you use this?

For general use, BPC 157 can be taken either orally or inject the peptides under the skin (subcutaneously) once daily. If injury-specific, dosing is SPLIT into TWICE DAILY injections under the skin specifically around the injury site.

Possible side effects include redness, itching, or swelling at the injection site. You should tell your healthcare provider about any side effects you experience. 

You can find more information at pepties.com.  That’s peptides without the D. Where we are tying all the peptide information together. 

Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast please share it with your friends and family on social media and have a happy, healthy week!

Check out this episode!

[thepeptidepodcast]

Ipamorelin

Today we are talking about Ipamorelin and its potential benefits. All this and more in less than 2 minutes. 

What is Ipamorelin?

Ipamorelin is a lab-made, primarily functioning as a growth hormone-releasing peptide (GHRP) or inducer. Ipamorelin works by mimicking the body’s natural release of growth hormone release. It does this by increasing the number of somatotrophs (or cells responsible for growth hormone release) and it suppresses somatostatin (a growth hormone inhibiting hormone). 

Ipamorelin is often used in combination with CJC 1295 because they work well together. This combination will promote the increase of growth hormone and is used for anti-aging purposes and in people with inflammatory conditions or those who have low IGF-1 levels.

So what are the benefits?

Like CJC 1295, Ipamorelin is useful to those looking to increase lean muscle mass and strength by stimulating the release of growth hormone. It also promotes muscle recovery from workouts and helps the growth of muscle tissues resulting in quicker recovery times.

Ipamorelin also leads to increased energy, improvements in sleep, and bone density.

BUT DOES IT WORK? 

Like we said last week…Peptide therapies are not miracles in a bottle. They don’t guarantee desired results. Like anything in life, you must also make lifestyle changes when it comes to certain desired outcomes. For example, a poor diet and lack of exercise can have a very negative impact on your health and cause weight gain, skin issues, joint pain, and can even lead to type 2 diabetes.

Peptide therapy in addition to healthy lifestyle choices can help you achieve your goals!

Possible side effects include redness or itching at the peptide injection site. You should tell your healthcare provider about any side effects you may experience. 

You can find more information at pepties.com.  That’s peptides without the D. Where we are tying all the peptide information together in one place. 

Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love what you’ve heard on this podcast please share it with your friends and family on social media. We’ll see you next time. Have a happy, healthy week!

Check out this episode!

[thepeptidepodcast]

CJC 1295

Today we are talking about CJC 1295 and its potential benefits. All this and more in less than 2 minutes. 

An excellent example of the ability peptides have to work together with our own bodies comes from a few of the most commonly used peptides available for anti-aging: growth hormone-releasing hormones (or GHRHs) and growth hormone-releasing peptides (GHRPs). 

As you know, aging is essentially our bodies breaking down at the cellular level. As we age, we deal with things like decreased muscle mass, decreased immune function, a decreased sex drive, increased skin issues, change in mood, the list goes on and on. 

All of this along with depression, and many more unwanted effects seem to inevitably come as part of the aging process. Some of this dysfunction can be treated with GHRH peptides like CJC-1295 or GHRP peptides like Ipamorelin or a combination of BOTH! Today we are going to focus on CJC 1295.

What is CJC 1295?

CJC 1295 is a lab-made peptide hormone, primarily functioning as a GHRH or amplifier. In simple terms, the peptide increases protein synthesis, human growth hormone (aka HGH) secretion, and insulin-like growth factor (or IGF-1). 

IGF-1 is a hormone that’s similar in molecular structure to insulin and plays an important role in childhood growth and has anabolic effects (or muscle-building effects) in adults. 

What are the BENEFITS? 

CJC 1295 is useful to those looking to increase lean muscle mass and strength by stimulating the release of growth hormone. It also promotes muscle recovery as it boosts protein synthesis levels and helps the growth of muscle tissues resulting in quicker recovery times for athletes and those with injuries. And because it stimulates the production of IGF-1, it can help decrease body fat and increase natural strength.

Compared to other peptide therapies, CJC 1295 has a longer half-life of 30 minutes which requires fewer peptide injections and results in the continual release of growth hormone. 

It also has minimal effect on cortisol levels. Cortisol is a hormone that’s released into your bloodstream when your body undergoes stress. This hormone causes an increase in your heart rate and blood pressure. It’s your natural “fight or flight” response. However, over time, if your body experiences repeated stress, you may begin to feel tired, irritable, depressed, and even experience weight gain.  

BUT DOES IT WORK? Peptide therapies are not miracles in a bottle. They don’t guarantee desired results. Like anything in life, you must also make lifestyle changes when it comes to certain desired outcomes. For example, a poor diet and lack of exercise can have a negative impact on your health and cause weight gain, joint pain, and can even lead to type 2 diabetes.

Peptide therapy in addition to healthy lifestyle choices can help you achieve your health goals!

Possible side effects include redness or itching at the injection site. You should tell your healthcare provider about any side effects you think you may be experiencing. 

You can find more information at pepties.com.  That’s peptides without the D. Where we are tying all the peptide information together in one easy place.

Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast please share it with your friends and family on social media. And subscribe to our podcast. Have a happy, healthy week!

Check out this episode!