#multipot

[aremesfermentis]

Revitalize Your Skin with Multipotent Regenerative Night Cream

Indulge in the rejuvenating power of our multipotent regenerative night cream, designed to repair and renew your skin while you sleep.

[charliefooks]

Getting my head around stem cells totipotent, pluripotent, multipotent

[cyberspacenine]

okay, i'm going to say something.

there are a lot of people who end up defending lestat's actions to some degree in season one, or downplaying the creepiness/abuse because they view them as "genuine acts of love towards louis". like, lestat just loves louis so much and this is how he expresses it.

here's the thing though. it doesn't matter how genuine the love is. i agree with you when you say that lestat loves louis, but that doesn't mean a person can't love someone and be horrible towards them. you can have a very warped sense of right & wrong and how to treat your partner and still feel love. parents who mentally/physically abuse their children or partners who abuse their lovers will tell you they love the person they are abusing, that's not some 4d chess manipulation.

this just means that "love" is something that can be utilized both for harm and for care. it is neutral, it is multipotent, it can take any form possible in the hands and eye of its beholder.

so when you say "but lestat really loved louis", my answer is "so what?" love did not prevent louis from getting mentally and physically hurt.

[transgenderer]

Estivating animals such as lungfish and amphibians form cocoon structures to reduce evaporative water loss in the dry season (17–19). African lungfish live inside their mucus cocoon for months or even years (20). Previous studies described the cocoon of anuran and urodele amphibians as shed epithelial layers, whereas the lungfish cocoon was described as a translucent brownish dried mucus structure (17, 19, 20–23). Estivating lungfish are likely more vulnerable to pathogen attack since they are immobile and continuous skin mucus secretion stops once the cocoon is formed. Thus, we hypothesized that the cocoon may have important immunological functions thus far undescribed. Our histological observations revealed that the lungfish cocoon is not a dead, dry mucus layer but, instead, is a living tissue with a well-defined cellular structure. The thickness of the lungfish cocoon was approximately 350 to 900 μm, although this may vary from body site to body site, and the distance between the epidermis and the cocoon ranged from 15 to 173 μm (Fig. 3A). The cocoon was composed of different cell types including goblet cells, epithelial cells, endothelial cells, and immune cells (Fig. 3B). Transmission electron microscopy confirmed the presence of goblet cells with many secretory mucus granules within the cocoon (fig. S3D). Moreover, abundant nests of cells were observed surrounded by long channels lined by double-layered squamous cells. A series of monolayered vessels running parallel and perpendicular to the main channel were identified. These nests of cells contained endothelium-lined vessels that could potentially serve to transport cells into and within the cocoon (Fig. 3B). Channels were not filled with mucosal secretions based on periodic acid–Schiff staining (Fig. 3C). The cocoon contained abundant granulocytic cells (fig. S2A) that were MPO+, indicating transmigration of granulocytes into the cocoon [fig. S2B; modeled in Fig. 2 (C and D)]. Scanning electron microscopy (SEM) showed that during terrestrialization, the flattened smooth epidermis of freshwater fish (Fig. 3E) became a disrupted surface covered by the cocoon where lungfish cells and groups of bacterial cells were observed

Free-swimming lungfish skin is characterized by a columnar mucosal epithelium. (A) Large numbers of multipotent stem cells with alkaline phosphatase activity (fig. S1) can be observed at the interphase between the epidermis and the dermis. Granulocyte deposits in the tissue reservoirs of free-swimming lungfish become mobilized to the skin via peripheral circulation when lungfish begin to sense lack of food and water. (B) Skin remodeling begins, with increasing numbers of granulocytes infiltrating the dermal and epidermal layers resulting in loosening of the basal membrane and inflammation. (C) The cocoon then starts to form by detachment and shedding of the inflamed epidermis. Many granulocytes are part of the cocoon, and they produce ETs in response to the high microbial load. Epithelial cells, goblet cells, and antimicrobial peptides (AMPs) are also present in the cocoon. The pool of stem cells starts to regenerate the epidermis, while granulocytes continue to arrive from reservoirs maintaining an inflammatory state. (D) In the next stages of estivation (end of the induction phase), the lungfish skin shows complete flattening of the epidermis and goblet cell exhaustion. The cocoon has several layers derived from multiple rounds of epidermal shedding and regeneration, and stem cell numbers are severely reduced. Granulocytes in the cocoon continue to undergo ETosis and are still elevated in the epidermis and dermis compared to free-swimming controls. It is unknown whether the cocoon continues to thicken beyond 2 weeks after terrestrialization

(source) when lungfish hide in the dirt in the dry season, their skin dissolves into a living cocoon full of immune cells! they have huge reservoirs of white blood cells at all times, so if they suddenly dry out they can pump them into the cocoon

[just-an-emily-existing]

😈The Wizardry of The Dark Arts😈

😈Facts and Silly Things😈

The Dark Arts is a power mainly ghosts can possess but sometimes, a mortal with a raw sense of power can harness this magic and thrive with it.

These engines are very stealthy and hide in shadows to hide from the world, as Dark Magic is still something the vast majority of humans aren’t willing to accept.

Dane is the one who is able to harness this power and give it to those he deems worthy of his magic.

Their signature body part is their eyes, they all have dark black eyes with red/white pupils, and for some like Dane, their eyes can become swirly, hypnotising their victims into a deep trance they can’t escape from unless the manipulator says so (RIP Thumper).

They can give their victims nightmares, make them hallucinate, curse, hex, or jinx them, and summon the lowly souls of the damned to drive their victims insane.

These engines are very unhinged, so be careful when interacting with one, if you have the misfortune of coming across one.

They can also turn invisible if their in shadows but can be easily found by a light engine.

If they’re super upset/depressed/angry, then the ground around them will start to die, and will gain a shadow around them full of darkness and death, make sure to get out of their way or else you’ll quickly be infected with their darkness and slowly or quickly die depending on how close you are. (Think of Rapunzel’s Death Incantation)

Dark Magic is an incredibly powerful form of witchcraft that draws on malevolent powers, and may be used for evil purposes that deliberately cause harm in some way, e.g. to cause destruction or misfortune, or to injure and kill without regard or remorse for human life.

They all have chains on their wrists, the longer the chains are, the more unfinished business they have and vice versa.

😈Now onto their Prowess (Abilities)!😈

Shadow Teleportation: They can teleport using shadow, but being flashed with light while teleporting can stop them and bring them back to their original point.

Telekinesis: They can move things or even people with their mind.

They’re incredibly good at magic, or making potions, just all sorts of witchy stuff.

Shadow Creation : The ability to create shadows or dark areas, potentially using them as shields or barriers.

They can animate their or other people's shadow.

They have night vision, and their eyes glow with a camera like cats.

They have a tendency to attract bad luck or give their bad luck to others.

Emotional Drain: Drain the emotions of others, leeching energy and power from the target and transferring it to the user.

Psychometry: Gain detailed information about objects, people, events, etc by using the five senses.

Astral Projection: Let the user's mind/spirit to exit the user's body and freely travel across time and space. (Leaves the user's body unprotected and vulnerable).

Super Apathy: Remain emotionless and detached, no matter situation.

Mind Exchange: Swap minds between the user and a target, or between two or more targets.

Possession: Take control of the bodies and minds of others.

Xenoglossy: Speak a language fluently without having ever learned it before.

Multipotence: Know what is happening in multiple locations at once.

Dimension Gate: Create and travel through dimensional gates.

When an Engine dies, they will immediately lose their magic and become a Dark Magic Engine.

Memory Walking: The ability to go into someone's mind and either walk or relive the person's memories. Think of Steven Universe walking through Pearl's memories

😈What sets them apart from the other Elements?😈

This is the only element that isn’t possessed by Lady, but another engine who has conjured this power from a raw will of power and a horrific mental psychosis. The majority of mortals, engine or human cannot handle this power and can only be harnessed by the dead. This is also a very evil and demonic power, but still very important to Sodor. What’s an culture without its ghost stories? They can best be defined by the fact they have no legs, grey skin, a slight transparent figure, their eyes will be like the one's below, and with chains around their wrists, the more chains on their wrists, the more unfinished business they have with the living. Once all the chains are gone they can either ascend to Heaven, or choose to stay and roam the Earth.

😈Stained Glass😈

😈Scythe: Dark Magic's Signature Weapon😈

😈Tapestry😈

😈Roller Skate Mechanics😈

😈Sigil Of The Dark Arts😈

[vyvybug]

I know you've made genderfluid potion designs before, but I was wondering if you could please make one that have bisexual on the bottom or vice versa.

I love these designs, and I think it would be fun (not just because they're two of my identities) because the colors are very similar, so it would feel very cohesive.

Thank you for your time and lovely work!

they works so well together! here you go! thanks for the suggestion :]

I really thought I had done more bi multipotions, i guess I'll do a bunch more in the morning lol

[kiwimart5]

embryos from stem cells??

Researches have created human embryo-like structures from no egg or sperm- but stem cells? But, what are stem cells?

Stem cells are special types of cells in the human body that can develop into other cells.

And because of this multipotent ability, scientists were able to use the naive stem cells as a base before adding chemicals and other paraphernalia. The full details of the process behind this extraordinary creation can be found through the official University of Cambridge website.

This is such an important part of research in medicine as a whole and really affirms the belief that new cures for even genetic disorders can be found. Truly a brutally smrt move from medical engineers.

[rylana404]

*gives you a compleatly random powerset*

*Multipotence*

shit-

ack-

so much information

[worldnewsbd]

Can COPD be treated with stem cell therapy?

Introduction

Chronic obstructive pulmonary disease, or COPD, refers to a group of progressive lung diseases characterized by long-term breathing problems and poor airflow. The two main conditions that fall under the COPD umbrella are chronic bronchitis and emphysema. As the lungs and airways become damaged from environmental pollutants like cigarette smoke, it becomes progressively harder for the lungs to function normally. This often leads to symptoms like shortness of breath, coughing, wheezing, fatigue, and other issues that significantly impact quality of life.

Currently, medication is relied on to treat and manage COPD symptoms, though it does not reverse underlying damage or restore lung function. Other options like pulmonary rehabilitation, oxygen therapy, lung transplantation, and smoking cessation can also help in severe cases. However, there remains an unmet need for an intervention that can repair damaged tissue and regenerate lost lung cells. This has led researchers to explore whether stem cell therapy may hold promise as a treatment for COPD.

What are stem cells?

Stem cells are unique cells in our bodies that can both self-renew and differentiate into specialized cell types. There are different classes of stem cells:

Embryonic stem cells: Derived from embryos within a few days of fertilization, these cells are considered pluripotent, meaning they can become any cell type in the body. However, research on human embryos faces ethical issues.

Induced pluripotent stem cells (iPSCs): Adult cells that have been genetically reprogrammed to an embryonic stem cell-like state with pluripotency. iPSCs avoid the use of embryos.

Adult (somatic) stem cells: Present in adult tissues like bone marrow, brain, blood, skin, and muscles. They are multipotent, with the ability to become a few specialized cell types.

In the context of COPD, mesenchymal stem cells (MSCs) hold particular promise. MSCs are multipotent adult stem cells that can differentiate into cells that make up muscles, bones, cartilage, fat, and other connective tissues. They are most commonly derived from bone marrow but can also be found in fat, dental pulp, and umbilical cord blood.

How could stem cells help treat COPD?

Research suggests MSCs may help treat COPD through these mechanisms:

Lung regeneration: MSCs have the potential to differentiate into lung cell types like epithelial cells, endothelial cells, and pneumocytes that form the gas exchange surface in the lungs. This raises hopes that MSCs could help regrow damaged or missing lung tissue.

Immunomodulation: MSCs secrete cytokines and growth factors that reduce inflammation and regulate the immune system. Persistent inflammation driven by the immune response is a major factor in COPD progression.

Angiogenesis: MSCs stimulate the growth of new blood vessels. In COPD, impaired vascularization and oxygen delivery to lung tissues are issues that may be addressed in this manner.

Antifibrotic effects: COPD lungs experience fibrosis or scarring of pulmonary tissue. Studies show MSCs help reduce fibrosis and promote wound healing through matrix remodeling enzymes.

Neurotrophic support: Dysregulation of the pulmonary neuroimmune axis occurs in COPD. MSCs secrete neurotrophins to stabilize the local neural microenvironment in the lungs.

Overall, through their multipotent and immunomodulatory properties, MSCs aim to suppress lung destruction, restore lung function, and mitigate symptoms in COPD through tissue repair and regeneration. Let's explore the evidence behind this stem cell approach.

Clinical trial evidence

A range of small, early-phase safety and proof-of-concept trials have investigated the potential of stem cell therapy in COPD patients so far:

Intravenous infusion: In a phase I trial, 20 COPD patients received two intravenous infusions of autologous bone marrow-derived MSCs a month apart. At six months, significant increases in exercise capacity and health-related quality of life were observed compared to baseline, along with decreased emphysema in high-resolution CT scans. Similar improvements were seen in other studies testing intravenous MSC administration.

Endobronchial transplantation: Another phase I study involving 14 patients delivered autologous bone marrow-derived MSCs via a bronchoscope into the lungs. At three months, lung function and walking distance increased while clinical symptoms decreased relative to before treatment. Endobronchial delivery likely enhances engraftment in the target tissues.

Intratracheal infusions: A trial in 16 COPD patients evaluated fat-derived MSCs administered by bronchoscope through the trachea. Post-treatment, they saw elevated levels of the lung surfactant-associated protein-A and reduced numbers of inflammatory cells in bronchoalveolar lavage fluid, implying a dampened inflammatory reaction alongside potential regeneration.

While the numbers are still low, no significant safety issues have been reported with MSC use in COPD trials thus far. Further evaluation in larger cohorts continues across the world. Platform trials like ONE-BRIDGE are also exploring more variables including factors like donor age, route of administration, and dosage levels.

Real-world examples

R3 Stem Cell is a stem cell bank based in India with facilities for treating patients using autologous adipose stem cell therapy for various conditions. On their site, they discuss indications for which they have seen benefits with COPD patients, including:

Improved breathing patterns and lung capacity parameters like FEV1 and FVC. Following treatment, patients demonstrate measurable gains in pulmonary function parameters.

Reduced exacerbations and fewer hospitalizations. Patients experience far fewer worsenings of respiratory symptoms requiring medication changes or hospital admissions post-treatment.

Enhanced quality of life. Patients note returned abilities to conduct daily chores, perform physical work and exercise, and an overall better feeling of well-being.

Improved breathing comfort and exercise tolerance. Shortness of breath is diminished. Patients find they no longer get breathless from routine movements and can walk longer distances without gasping for air.

Mitigation of chronic lung infections. With strengthened immunity and fewer exacerbation-prompted hospital visits where patients are exposed to illnesses, recurring lung infections tend to attenuate.

Disease stabilization halts further decline. For patients whose lung function was progressively deteriorating each year, treatment allows stabilization preventing additional loss.

These observations provide real-world insight into how adipose stem cell therapy may benefit COPD patients outside the constraints of clinical trials. Of course, larger studies are still vital to fully validate the approach.

Future considerations

While preliminary results are promising, stem cell therapy for COPD remains in the exploratory phase. Questions that still need answers include:

Determining the optimal cell dose and route of administration. More research aims to establish standardized protocols.

Longer-term follow-up data. Currently, most trials only follow patients up to 6-12 months. Longitudinal studies spanning years are essential.

Delineating which COPD subgroups benefit most. Further stratification is important based on disease severity, emphysema presence, exacerbation frequency, and other criteria.

Elucidating the precise mechanisms of action via lung tissue analysis. Further validation of stem cell effects on regeneration, remodeling, and inflammation modulation is underway.

Conducting comparative effectiveness studies. Head-to-head trials against conventionally available COPD treatments will help define the treatment landscape.

Ensuring consistent quality and safety across providers. Optimization of donor screening, cell manufacturing, and administration standards on large cohorts will strengthen the field.

As more long-term safety and efficacy results emerge, stem cell therapy could become an accepted component of COPD management. It holds great potential to improve care for a condition representing a major worldwide health burden. Further clinical advances and research remain on the horizon.

Conclusion

In summary, while definitive conclusions are still being drawn, initial experiments show stem cell therapy may effectively treat COPD symptoms through regenerative and immunomodulating actions. Mesenchymal stem cells administered through various routes seem to help minimize lung injury and enhance recovery by regenerating tissue and counteracting inflammation. Real-world cases also confirm gains in lung function and quality of life following treatment through adipose stem cell therapy. While larger controlled studies are still warranted, early evidence establishes stem cell therapy as a promising avenue worth further exploration for COPD, a progressive and irreversible disease currently lacking an intervention that can reverse the damage. Continued investigation will likely optimize this cell-based approach and bring it closer to becoming part of standardized COPD care pathways.

[breelandwalker]

Darling, I'm three gremlins in a trenchcoat on a GOOD day. I'm sure you'll manage. 😁

Incidentally....

Primary: Data Manipulation

The ability to manipulate data/digital information. Sub-power of Record Manipulation, Technology Manipulation and Knowledge Manipulation. Variation of Artificial Element Manipulation. Opposite to Physical Information Manipulation.

Secondary: Conceptual Magic Attacks

The ability to use conceptual magic for various attacks. Sub-power of Conceptual Magic. Variation of Magic Attacks.

Archetype: One Trick Wonder

The character is extremely powerful but with a very limited power set. Opposite to All-Rounder and Multipotent Power Wielder.

........I have a very particular set of skills.

First, see what random superpower you get.

Second, see the other half of your powerset.

Lastly, see what character archetype you'll be.

[pairfum]

The Power of Exosomes in Skincare: Unlocking Youthful Skin

Exosomes are revolutionising skincare, but what exactly are they, and how do they work? These tiny extracellular vesicles are released by nearly every cell in the body and have become a major focus in both medical and cosmetic research. While traditional skincare treatments work mainly on the surface, exosomes go deeper, communicating at a cellular level to stimulate regeneration, reduce inflammation, and repair damaged tissue. This next generation of biologically active ingredients is unlocking new levels of skin rejuvenation, backed by science and rapidly growing clinical interest.

Understanding Exosomes: What Are They?

Exosomes are a type of extracellular vesicle that measure between 30 and 150 nanometres. They originate within a cell’s endosomal network and are released when multivesicular bodies fuse with the plasma membrane. These vesicles play a critical role in intercellular communication by transferring proteins, lipids, exosomal RNA, exosomal microRNA, and exosomal DNA to target cells. Through this transfer, exosomes influence the biological activity of recipient cells and contribute to tissue homeostasis. Most exosomes are created through exosome biogenesis, a process that begins with the formation of intraluminal vesicles within a multivesicular body. Once this body merges with the plasma membrane, its vesicles are released into the extracellular space. The structure of each vesicle includes a lipid bilayer derived from the plasma membrane, which helps preserve the stability of its cargo of proteins and nucleic acid. Exosomes are secreted by various cell types, including epithelial cells, dendritic cells, b cells, t cells, endothelial cells, tumor cells, and immune cells. Their role in intercellular communication is crucial across many physiological and pathological processes.

Exosomes in Skincare: Why They Matter

The use of exosomes in skincare has gained attention due to their regenerative capabilities. Unlike most topical treatments, derived exosomes can deliver bioactive molecules directly into the skin’s deeper layers. This direct communication with skin cells promotes the production of collagen, enhances hyaluronic acid retention, and encourages cellular repair. The result is smoother, firmer, and more hydrated skin. In particular, stem cell derived exosomes from plant and animal sources are known to modulate the function of skin cells by delivering proteins that stimulate tissue regeneration and skin rejuvenation. These extracellular vesicles act as messengers, ensuring that t cells and other immune players respond appropriately to environmental stressors and age-related damage.

Sources of Derived Exosomes in Skincare

Plant Derived Exosomes Plant derived exosomes offer a natural, non-allergenic option. They are rich in antioxidants and bioactive compounds that reduce oxidative stress and promote a balanced skin barrier. These vesicles have gained popularity for their regenerative and soothing properties. Animal and Human Derived Exosomes Animal derived exosomes are collected from sources such as avian, bovine, porcine, and fish cells. Each cell type offers a unique exosomal profile. For instance, bovine derived exosomes have been shown to support collagen production, while fish derived exosomes may aid in hydration and nutrient delivery. Human derived exosomes are more controversial due to ethical and regulatory concerns, but they are among the most biologically compatible with skin cells. Stem Cell Derived Exosomes Stem cell derived exosomes are among the most potent. These include vesicles released by mesenchymal stem cells and other multipotent cell lines. Mesenchymal stem cell exosomes are known to enhance wound healing, reduce inflammation, and improve elasticity. They also show great promise in regenerative medicine and exosome therapy, particularly for skin regeneration and anti-ageing.

Biological Benefits of Exosome Therapy in Dermatology

Boosting Skin Repair and Collagen Synthesis Exosome therapy enhances collagen synthesis by delivering regulatory proteins and growth factors into the dermis. This supports fibroblast activation and dermal remodelling, restoring skin firmness and resilience. Hydration and Elasticity Exosomes help maintain skin hydration by supporting hyaluronic acid synthesis. By fortifying the extracellular matrix, these extracellular vesicles prevent transepidermal water loss, improve elasticity, and enhance the skin’s natural glow. Anti-inflammatory and Immune Modulation Dendritic cells and t cells are key players in skin immunity. Exosome treatments can regulate their activity to reduce chronic inflammation, making them beneficial for acne-prone and sensitive skin. This immunomodulatory effect helps improve the skin’s ability to heal without irritation. Skin Rejuvenation and Regeneration Through their rich cargo of proteins, exosomal microRNAs, and nucleic acid, exosomes rejuvenate ageing or damaged skin. Their natural origin makes them safe and efficient at delivering targeted support to the cells that need it most.

Targeted Skincare with Engineered Exosomes

Recent advancements in biotechnology have led to the development of engineered exosomes, which are modified to enhance delivery efficiency and therapeutic precision. These engineered vesicles can be tailored to carry specific bioactive cargo, such as exosomal miRNAs, that regulate gene expression in recipient cells. When used in skincare, a cell derived exosome—especially those formulated into an exosome serum—can deliver these molecular signals directly to the skin’s deeper layers. Research shows that exosomal miRNAs play a critical role in modulating inflammation, collagen production, and overall cellular rejuvenation, making them a powerful component in next generation skincare applications.

The Cellular Mechanisms Behind Exosome Action

Exosome biogenesis begins inside the cell when early endosomes mature into multivesicular bodies. During this maturation, intraluminal vesicles are formed. These intraluminal vesicles later become exosomes when the multivesicular body fuses with the plasma membrane and releases its contents. Once released, exosomes travel through extracellular fluid to reach their target cells. Upon binding with the plasma membrane of these target cells, they either fuse directly or are endocytosed, delivering their proteins and genetic material into the recipient cell. This targeted interaction ensures precise modulation of biological pathways, especially those involved in skin cell turnover and repair. Each vesicle is engineered by its cell of origin to serve a specific function. For example, dendritic cells use exosomes to influence antigen presentation, while t cells utilise them in immune regulation. In skincare, these same principles are harnessed to influence skin physiology at a microscopic level.

Exosome Research and Clinical Development

The field of exosome research is rapidly growing. As of this writing, a quick search on Google Scholar reveals thousands of peer-reviewed papers discussing exosome therapy and their applications across dermatology, oncology, and regenerative medicine. Clinical studies have shown that derived exosomes can reduce signs of skin ageing, speed wound healing, and improve skin tone and texture. Studies in the International Journal of Molecular Sciences, for example, confirm the potential of msc derived exosomes in anti-ageing skincare due to their antioxidant and regenerative effects. Other articles indexed on Google Scholar and ScienceDirect suggest that stem cell derived exosomes could soon become a standard tool in aesthetic dermatology. Moreover, there is rising interest in exosome isolation techniques and standardisation of exosome products to ensure consistency and efficacy in skincare.

Exosomes Beyond Beauty: Therapeutic Potential

Exosomes are also being explored for their applications in treating more complex conditions. In oncology, cancer cell derived exosomes are being studied for their role in tumour progression, immune evasion, and even as biomarkers. Tumor cells actively release extracellular vesicles that manipulate immune cell responses and support metastasis. At the same time, researchers are developing engineered exosomes that can deliver drugs directly into cancer cells, offering a precise, less toxic alternative to chemotherapy. Bone marrow derived mesenchymal stem cells have demonstrated strong therapeutic potential across tissue types. In addition, extracellular vesicles released from endothelial cells show benefits in vascular repair, with implications in both medicine and aesthetic treatments.

A Fragrant Finish to Scientific Skincare

As you care for your skin at a cellular level, consider how your surroundings can elevate your wellbeing. A refined environment supports a refined ritual. Pairfum’s Flacon Room Spray Perfume offers a subtle yet sophisticated way to transform your space. Just as exosomes deliver rejuvenation deep within the skin, a single spritz of this fragrance infuses the air with a serene and lasting aroma, helping to complete your self care experience in the most elegant way. Flacon Perfume Room Spray - by Pairfum London Encased in a handcrafted glass flacon, this room spray is more than a scent—it is an interior statement. The carefully curated fragrance blends are long lasting and beautifully layered, created in-house by expert perfumers. Designed to uplift and calm, it provides a fragrant atmosphere that lingers gently in your home. With no need for flames or plugs, it delivers luxury with simplicity, echoing the quiet power of advanced skincare.

Conclusion: The Future of Exosome Skincare

From basic cell biology to luxury skincare, exosomes are redefining what’s possible in dermatology. As exosome isolation, biogenesis, and application methods continue to evolve, skincare formulations will become more intelligent, personalised, and biologically effective. With extensive support from scientific literature, including thousands of publications on Google Scholar, and robust studies on extracellular vesicles and stem cell therapy, the integration of exosome products into skincare is only just beginning. Whether sourced from mesenchymal stem cells, t cells, or plant derived exosomes, these biologically active vesicles offer powerful, natural tools to restore, protect, and enhance the skin from within. This is not merely a trend, but a significant scientific advancement, one that blends cellular biology, dermatology, and the art of skincare into a unified, high-performance approach. Exosome therapy and exosome treatment hold the potential to become the cornerstone of future skin health innovation. Read the full article

[cytgen]

Abstract Peripheral nerve injury (PNI) is a relevant biomedical problem, especially in wartime, given the high frequency of such injuries. Bioengineering means for rehabilitative treatment of PNI are considered the most promising, among which the effect of stem cell transplantation into the subarachnoid space on the process of plastic reconstruction of the nervous system in the context of PNI is the least studied. In this study, we investigated the effect of delayed transplantation of two types of human stromal multipotent stem cells into the cisterna magna on the restoration of the functional index of the sciatic nerve (sciatic functional index, SFI) after its transection and immediate epineural suturing in adult rats. The obtained data indicate that delayed intrathecal xenotransplantation of dermal multipotent stromal stem cells or multipotent mesenchymal stem cells, derived from the wall of umbilical artery, performed 2 weeks postinjury, leads to a significant increase in SFI after 2.5 months of observation. In the case of umbilical artery-derived stem cells’ injection, this result is significantly higher than the result of sciatic nerve suturing without the procedure of cell transplantation.

[viezec]

Different Types Of Stem Cells Used In Treatment.

Stem Cells are distinguished by their remarkable ability to self-renew and differentiate into specialized cell types. This unique property sets them apart from other cells, making them crucial for tissue repair and regeneration. Stem cells can be broadly categorized based on their potency, which refers to their ability to differentiate into different cell types. These categories include totipotent, pluripotent, multipotent, oligopotent, and unipotent stem cells.

https://www.viezec.com/category/stem-cell-therapy/

[xtruss]

Three New Classes of Obesity-Related Adipocyte Progenitor Cells Identified

— By Bob Yirka | Medical XPress | April 26, 2025

DPP4+ multipotent progenitor cells give rise to ICAM1+ and CD142+ committed preadipocytes, which are poised to differentiate into mature adipocytes (top). Committed preadipocytes (green) are intercalated between mature adipocytes, whereas DPP4+ progenitors (red) reside in the reticular interstitium, an anatomically distinct fluid-filled network of collagen and elastin fibers that encases many organs, including adipose depots. Credit: Science (2019). DOI: 10.1126/science.aav2501

A team of researchers with the Perelman School of Medicine at the University of Pennsylvania has identified three new classes of obesity-related adipocyte progenitor cells in humans. In their paper published in the journal Science, the group describes their study of new adipocyte formation from progenitor cells within fat tissue and what they found. You-Ying Chau and William Cawthorn with the University of Edinburgh have published a Perspective piece on the work done by the team at UoP in the same journal issue.

Chau and Cawthorn note that fat storage by the body is more than just a means of keeping an extra energy store around in case of lean times, it is also the means by which organs in the body are protected from ectopic lipid accumulation, which can lead to damage. They also note that one of the ways that scientists are looking to combat obesity is by better understanding the ways fat accumulates in the body. Prior research has shown that fat expansion happens in two ways: by fat cells increasing in size and by fat cells increasing in number. The first leads to obesity, the second helps to prevent it. Scientists also know that fat expansion is dependent on the creation of new adipocytes that come about from progenitor cells that live inside of fat tissue. Prior research has also shown that there are different kinds of adipocyte progenitor cells (APCs) in fat tissue, but until now the role they play in fat expansion has not been clear. In this new effort, the researchers have identified three new classes of APCs that play a role in the development of obesity.

In order to find the newly discovered APCs, the researchers had to use a new technique called fluorescence-activated cell sorting—it allowed for separating fat cells based on specific proteins in them. Once that was done, the team carried out single-cell RNA sequencing which allowed them to separate cells into groups based on similarities between them. The team reports that most of the cells they were studying fell into one of three previously unknown groups: interstitial progenitor cells, preadipocytes and group 3. Cells from each group were removed and isolated and allowed to grow cell cultures which showed them forming adipocytes. The researchers suggest more study of members of the newly defined classes of APCs could lead to new ways to battle obesity by promoting fat cell number increases instead of size increases.

[langde01]

5 Types of Stem Cells and Their Medical Potential

Stem cells have revolutionized the field of medicine with their potential to regenerate, repair, and replace damaged tissues. As research continues to advance, understanding the different types of stem cells becomes crucial for both patients and healthcare providers. In this blog, I’ll walk you through the five main types of stem cells, each with its own unique characteristics and clinical significance.

1. Embryonic Stem Cells (ESCs)

Source: Early-stage embryos Potential: Pluripotent – can become almost any cell type in the body.

Use in Medicine: Embryonic stem cells hold promise for regenerating damaged tissues such as nerves, heart muscle, and pancreas. Their ability to turn into any cell type makes them valuable for studying development and testing drugs. However, their use raises ethical concerns, which have limited widespread clinical applications.

2. Adult Stem Cells (Somatic Stem Cells)

Source: Adult tissues like bone marrow, fat, and blood Potential: Multipotent – can differentiate into a limited range of cell types.

Use in Medicine: These are commonly used in treatments such as bone marrow transplants for blood disorders. They are safer and ethically acceptable but have limited plasticity compared to embryonic stem cells.

3. Mesenchymal Stem Cells (MSCs)

Source: Bone marrow, fat tissue, umbilical cord Potential: Can differentiate into bone, cartilage, muscle, and fat cells.

Use in Medicine: MSCs are widely used in orthopedic treatments, sports injuries, and autoimmune conditions. They also show anti-inflammatory properties and promote healing, making them valuable in regenerative therapies.

4. Induced Pluripotent Stem Cells (iPSCs)

Source: Adult cells reprogrammed to act like embryonic cells Potential: Pluripotent – similar to embryonic stem cells.

Use in Medicine: iPSCs offer the benefits of ESCs without ethical issues. They are being explored in personalized medicine, genetic disease modeling, and drug testing. However, their long-term safety is still under investigation.

5. Perinatal Stem Cells

Source: Amniotic fluid, placenta, umbilical cord blood Potential: Multipotent and sometimes pluripotent properties.

Use in Medicine: These stem cells are rich in regenerative potential and have shown promise in treating neurological, cardiac, and autoimmune diseases. They are easy to collect and less likely to be rejected by the body.

Conclusion: The versatility of stem cells continues to transform modern medicine. From repairing tissues to treating chronic diseases, the possibilities are expanding every day. As we learn more about these cells, it’s clear that the future of regenerative medicine holds immense promise.

If you’re considering stem cell therapy or want to learn more about its benefits, feel free to consult me for personalized guidance and treatment options.Post navigation

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Bioethics Definitions Autonomy: "personal rule of the self that is free from both controlling interferences by others and from personal limitations that prevent meaningful choice" (Pantilat 2008). Non-maleficence: Not intending to cause harm to others -- 'to do no harm' according to Hippocratic principles Beneficence: "Beneficence is action that is done for the benefit of others. Beneficent actions can be taken to help prevent or remove harms or to simply improve the situation of others" (Pantilat 2008). Fidelity: Being faithful to the commitment made to one's professional ethics and to the patient under care Reparation: Making someone 'whole' again, after an injury has been done, or making amends in a way to specifically address the harms that were done by the perpetrator's wrong Palliative care: Care focused upon relieving the pain of patients suffering from serious illnesses, versus curing them Meta-ethics: The branch of ethics that strives to understand the principles behind ethical systems, versus practical questions Normative ethics: The study of ethics in practice Justice: Treating patients fairly and equitably, regardless of who they are (including their ability to pay, race or ethnicity, gender, age, etcetera). Falsification: According to Popper, for a statement to be considered scientific truth, it must be falsifiable (able to be proven false) Fabrication: Falsifying data or other evidence for nefarious purposes such as self-enrichment Ethics: Formal systems by which individuals make decisions about right and wrong Morality: The ideas about right and wrong established by consensus over time with in a society Virtue ethics: Ethics that focuses upon building a good character to generate good actions Deontological: Ethical worldview that focuses upon obeying timeless principles applicable to all occasions Utilitarianism: Ethical system that focuses in doing the greatest good for the greatest number of people Consequentialism: Ethical system that focuses on the consequences of actions, versus their intentions Advanced directive: A medical directive issued detailing what should be done if the person is no longer capable of making decisions for him or herself Medical power of attorney: "a document, signed by a competent adult, i.e., "principal," designating a person that the principal trusts to make health care decisions on the principal's behalf should the principal be unable to make such decisions. The individual chosen to act on the principal's behalf is referred to as an agent" (Medical power of attorney, 1999, Texas Medical Association) Ethical egoism: The idea that the ethical agent's first responsibility is to act in his or her own self-interest Ethical altruism: The idea that people have a moral obligation to help others Pluripotent: "Pluripotent cells can give rise to all of the cell types that make up the body; embryonic stem cells are considered pluripotent" (What is the difference between totipotent, pluripotent, and multipotent, 2013, NY State stem cell science). Totipotent: "Totipotent cells can form all the cell types in a body, plus the extraembryonic, or placental, cells" (What is the difference between totipotent, pluripotent, and multipotent, 2013, NY State stem cell science). Therapeutic cloning: Cloning specific cells to heal patients and replace damaged cells or organs, not to create whole, new human (or animal) entities Applied ethics: Specific, philosophical debates such as abortion or euthanasia to which ethical systems may be applied (Ethics, 2013, Internet Encyclopedia of Philosophy). Euthanasia: intentionally ending someone's life, usually for medical reasons (such as to prevent suffering). Q2. Describe the various types of euthanasia: Active euthanasia: Deliberately ending someone's life through the administration of drugs or other means Voluntary euthanasia: The patient 'actively' participates in the act of euthanasia Non-voluntary euthanasia: Euthanasia when the patient cannot explicitly consent to the action Q3. Describe the different definitions of death. Which do you support and why? "The most traditional way to tell if someone is dead has been to see if their heart is beating and if their lungs are breathing," but this is problematic given that many patients continue to live with artificial assistance to help their lungs and heart continue to function (Cline 2013). Brain death means a person can only function with technological intervention: "even though a person might suffer from whole brain death, he can still have a heartbeat which only ends due to the failure of the lungs. If the lungs are forced to keep breathing, such people can continue to digest food, excrete waste, and even bear children" (Cline 2013). In the case of total brain death, "the cessation of functioning in those parts of the brain responsible for consciousness and higher reasoning powers is necessary for the death of the 'person' aspect of the brain and body" has occurred (Cline 2013). Q4. Belmont report principles The 1979 Belmont report was intended to define "the boundaries between biomedical and behavioral research and the accepted and routine practice of medicine;" risk-benefit criteria in research involving humans and appropriate guidelines for research involving human beings and "the nature and definition of informed consent in various research settings" (Belmont, 1979, HHS). Q5. Present, explain and evaluate at least one argument in favor of thinking that many abortions are not morally wrong. No human being should be forced to harbor another human being against her will: a woman cannot be forced to endure the risks of pregnancy. For example, no one can be forced to donate a kidney to someone so the donor can survive, similarly the mother cannot be compelled to give up her body any more than one can be compelled to donate a kidney to save someone's life (Thomson 1996). Q6. For each of the thinkers below, identify by indicating pro-or con whether you believe the thinker would be in favor (pro) or against (con) the proposition above. In the space available to the right of the individual's name, justify your selection in two or three carefully constructed, legible sentences. Immanuel Kant: The principle of autonomy holds true in all instances. Thus in upholding this moral principle it is a sound notion that a woman does not compromise her autonomy, even if she becomes pregnant. Aristotle: Ultimately, the woman's good character, honed through ethical decision-making should allow her to determine whether abortion is moral or immoral. A good character will produce a good decision. John Stuart Mill: Regardless, the greatest good for the greatest number suggests that allowing abortion is permissible, given the negative consequences of making it illegal. Given that abortions will inevitably occur in the form of back alley abortions, allowing legal abortion promotes the general good. Q7. Compare first and second order reasons for abortion? "First order reasons are reasons of justifications which may plausibly justify an abortion, for example, (i) rape, (ii) endangerment of the woman's life, and (iii) a serious mentally or physically disabled fetus. Second order reasons are reasons of justifications which are, in comparison to first order reasons, less suitable in providing a strong justification for abortion, for example, (i) a journey, (ii) career prospects, (iii) by virtue of financial or social grievances" (Abortion, 2013, IEP). This notion of first and second order reasons, however, seems to penalize the woman for getting pregnant and not having 'good' reasons for having an abortion -- as if the 'risk' of sexual intercourse means that she may effectively be forced into pregnancy, as the implication is that second order reasons are less valid. References Abortion. (2013). Internet Encyclopedia of Philosophy. Retrieved: http://www.iep.utm.edu/abortion/ Belmont Report. (1979). HHS. Retrieved: http://www.hhs.gov/ohrp/humansubjects/guidance/belmont.html Cline, Austin. (2013). When and how should a person be declared dead? http://atheism.about.com/library/FAQs/phil/blphil_ethbio_death.htm Ethics. (2013). Internet Encyclopedia of Philosophy. Retrieved: http://www.iep.utm.edu/ethics/ Medical power of attorney. (1999). Texas Medical Association. Retrieved: http://www.texmed.org/template.aspx?id=65 Pantilat, Steven. (2008). Autonomy vs. beneficence. UCSF. Retrieved: http://missinglink.ucsf.edu/lm/ethics/contentpages/fast_fact_auton_bene.htm Thomson, Judith Jarvis. (1971). A defense of abortion. From Philosophy & Public Affairs, 1. 1. What is the difference between totipotent, pluripotent, and multipotent? (2013). NY State stem cell science. Retrieved: http://stemcell.ny.gov/faqs/what-difference-between-totipotent-pluripotent-and-multipotent Read the full article