#Adenovirus Vector Vaccine Market Demand

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Adenovirus Vector Vaccine Market Projected to Show Strong Growth

The Latest research coverage on Adenovirus Vector Vaccine Market provides a detailed overview and accurate market size. The study is designed considering current and historical trends, market development and business strategies taken up by leaders and new industry players entering the market. Furthermore, study includes an in-depth analysis of global and regional markets along with country level market size breakdown to identify potential gaps and opportunities to better investigate market status, development activity, value and growth patterns. Access Sample Report + All Related Graphs & Charts @: https://www.advancemarketanalytics.com/sample-report/165891-global-adenovirus-vector-vaccine-market

Major & Emerging Players in Adenovirus Vector Vaccine Market:- Creative Biolabs (United States), Sartorius AG (Germany), Lonza (Switzerland), Merck KGaA (Germany), Cobra Biologics (United States), Thermo Fisher Scientific (United States), Boehringer Ingelheim (Germany), Oxford Biomedica (United Kingdom), Advanced Bioscience Laboratories (United States). The Adenovirus Vector Vaccine Market Study by AMA Research gives an essential tool and source to Industry stakeholders to figure out the market and other fundamental technicalities, covering growth, opportunities, competitive scenarios, and key trends in the Adenovirus Vector Vaccine market. Adenovirus represents the class of the genetically diverse DNA viruses that can cause non-life-threatening infections related to eyes, respiratory system, gastrointestinal lining and other parts. These viruses represent promising results as a vector for delivering target antigens to various hosts due to excellent ability induce immune response. Due to these property, the new studies concluded positive results for use of adenovirus for both gene therapy and vaccine production. Adenovirus-based vectors shows various benefits when compared to other viral vectors such as wide range of tissue tropism, ease of genetic manipulation especially for large transgene DNA insertions, superior ability to induce robust transgene-specific T cell and antibody responses, easy production of the adenovirus based vaccines at large scale. Due to this, it has emerged as a preferred choice for delivering vaccine for both humans as well as animals.

In February 2021, the Janssen Biotech, a part of Johnson and Johnson submitted Emergency Use Authorization (EUA) to the US Food and Drug Administration (FDA), for its investigational single-dose coronavirus 2019 (COVID-19) vaccine candidate. The vaccine Ad26.COV2.S, is a recombinant, replication-incompetent adenovirus serotype 26 (Ad26) vector encoding a full-length and stabilized SARS-CoV-2 spike (S) protein

In January 2021, Thermo Fisher Scientific, a company offering range of instrumentation, reagents and consumables, and software and services acquired the viral-vector manufacturing business of the Novasep, a pharmaceutical company for approximately USD 875 million in cash. This acquisition is a step towards expanding Thermo Fisher capabilities in the cell and gene vaccines and therapies worldwide. The titled segments and sub-section of the market are illuminated below: by Type (Adenovirus-based tuberculosis vaccine, Adenovirus-based HIV vaccine, Adenovirus-based influenza vaccine, Others), Application (Human, Animals), End-user (Hospitals, Ambulatory Surgical Center, Research Institutes, Others) Market Trends: Increasing investment in vaccine and drug development

Rising collaboration between the pharmaceutical companies and CROs for development of adenovirus vector vaccine

Opportunities: Emergence of adenovirus vectored vaccines for COVID-19      

Production of low cost adenovirus vaccines

Market Drivers: Growing prevalence of chronic medical conditions

Rise in demand for efficient vaccines to treat infectious diseases Enquire for customization in Report @: https://www.advancemarketanalytics.com/enquiry-before-buy/165891-global-adenovirus-vector-vaccine-market Some Point of Table of Content: Chapter One: Report Overview Chapter Two: Global Market Growth Trends Chapter Three: Value Chain of Adenovirus Vector Vaccine Market Chapter Four: Players Profiles Chapter Five: Global Adenovirus Vector Vaccine Market Analysis by Regions Chapter Six: North America Adenovirus Vector Vaccine Market Analysis by Countries Chapter Seven: Europe Adenovirus Vector Vaccine Market Analysis by Countries Chapter Eight: Asia-Pacific Adenovirus Vector Vaccine Market Analysis by Countries Chapter Nine: Middle East and Africa Adenovirus Vector Vaccine Market Analysis by Countries Chapter Ten: South America Adenovirus Vector Vaccine Market Analysis by Countries Chapter Eleven: Global Adenovirus Vector Vaccine Market Segment by Types Chapter Twelve: Global Adenovirus Vector Vaccine Market Segment by Applications What are the market factors that are explained in the Adenovirus Vector Vaccine Market report?

– Key Strategic Developments: Strategic developments of the market, comprising R&D, new product launch, M&A, agreements, collaborations, partnerships, joint ventures, and regional growth of the leading competitors.

– Key Market Features: Including revenue, price, capacity, capacity utilization rate, gross, production, production rate, consumption, import/export, supply/demand, cost, market share, CAGR, and gross margin.– Analytical Tools: The analytical tools such as Porter’s five forces analysis, SWOT analysis, feasibility study, and investment return analysis have been used to analyze the growth of the key players operating in the market. Buy This Exclusive Research Here: https://www.advancemarketanalytics.com/buy-now?format=1&report=165891 Definitively, this report will give you an unmistakable perspective on every single reality of the market without a need to allude to some other research report or an information source. Our report will give all of you the realities about the past, present, and eventual fate of the concerned Market. Thanks for reading this article; you can also get individual chapter wise section or region wise report version like North America, Europe or Asia. Contact US : Craig Francis (PR & Marketing Manager) AMA Research & Media LLP Unit No. 429, Parsonage Road Edison, NJ New Jersey USA – 08837 Phone: +1 201 565 3262, +44 161 818 8166 sales@advancemarketanalytics.com

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Detailed Report on Upstream Bioprocessing Market  | BIS Research 

Upstream Bioprocessing refers to the initial phase of Biopharmaceutical production that involves the preparation and growth of cells or microorganisms to produce the desired biological product. 

The Global Upstream Bioprocessing Market was valued at $250.1 million in 2023 and is expected to reach $1,639.1 million by 2033, growing at a CAGR of 20.68% between 2023 and 2033.

Upstream Bioprocessing Overview 

Upstream Bioprocessing is an advanced manufacturing approach used in the production of biological products, including pharmaceuticals, biopharmaceuticals, and industrial enzymes. This method is characterized by the uninterrupted flow of materials through the production process, from the initial cultivation of cells or microorganisms to the final product purification.

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Key Stages involved in Upstream Bioprocessing 

Cell Line Development 

Media Preparation 

Bioreactor Cultivator 

Monitoring and Control

Key Applications for Upstream Bioprocessing 

Biopharmaceutical Production 

Monoclonal Antibodies 

Recombinant Proteins 

Vaccines 

Gene Therapy- Production of viral vectors (such as lentivirus and adenovirus) for delivering genetic material in gene therapy applications.

Cell Therapy - Cultivation of stem cells and other cell types used in regenerative medicine to repair or replace damaged tissues and organs.

Agricultural Biotechnology - Development of genetically modified organisms (GMOs) and biofertilizers to enhance crop yield, pest resistance, and nutrient utilization.

Market Drivers for Upstream Bioprocessing Market  

Growing demand for Biopharmaceuticals 

Advancements in Biotechnology 

Expansion of Personalized Medicines 

Technological Innovations 

Environmental Sustainability 

These market drivers collectively contribute to the growing adoption and expansion of the Upstream Bioprocessing Market

Recent Developments in the Upstream Bioprocessing Market

• Waters and Sartorius expanded their partnership to develop integrated analytical tools for downstream biomanufacturing following their successful collaboration in upstream processes. •  Sartorius and Repligen Corporation launched an integrated system with Biostat STR and XCell ATF for upstream process intensification.

Visit our Life Sciences and Biopharma Vertical page for better understanding 

Key Players in the market 

•   3M •   Bio-Rad Laboratories, Inc. •   Thermo Fisher Scientific, Inc. •   Merck KGaA •   Sartorius AG •   Danaher Corporation

Key Questions Answered

Q What is the estimated global market size for the Upstream Bioprocessing Market ?

Q What future trends are expected in the Upstream Bioprocessing Market ?

Q  What does the supply chain of the Upstream Bioprocessing Market  look like?

QWhat does the value chain of the Upstream Bioprocessing Market  look like?

Q  What is the regulatory framework within the Upstream Bioprocessing Market ?

Q  What is the patent analysis trend based on country and year in the Upstream Bioprocessing Market ?

Q  How has the COVID-19 outbreak affected the future trajectory of the Upstream Bioprocessing Market ?

Q What are the next frontiers in the Upstream Bioprocessing Market ?

Conclusion

Upstream bioprocessing is a critical and foundational phase in the production of biopharmaceuticals, playing a vital role in the cultivation and optimization of cells or microorganisms to produce high-quality biological products.

As the biopharmaceutical industry continues to evolve, upstream bioprocessing will remain a cornerstone, driving the development of new and innovative therapies that improve patient outcomes and address unmet medical needs.

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Viral Vector Gene Delivery Market: Advancements, Opportunities, and Future Trends

Market Overview 

Viral vector is the most sought-after way to transfer genes to specific cell types or tissues and manipulate them to express therapeutic genes. Currently, there are several types of viruses, such as adenovirus, adeno associated virus, baculovirus and retrovirus, which are being investigated in order to deliver the genes to required cells. This process can provide permanent as well as transient transgene expression.

Market Dynamics 

Viral vectors are primarily used in the development of various gene therapies and are showing great promise in disease landscape. Moreover, during the unprecedented times of COVID-19, the development of adenovirus-vector vaccine has helped to mitigate the dangerous risks associated with the pandemic.? 

Since the viral vector-based gene therapies have shown promising results in the past, the developers are exploring its full potential to reach to its long-term success. With the ongoing rise in demand, the service providers are continuously expanding their facilities to meet the numbers. In August 2022, Thermofischer has expanded its cell and gene therapy capability by opening the new viral vector manufacturing facility in Massachusetts, US. 

In June 2022, VIVEbiotech has completed the acquisition of its lentiviral vector manufacturing capabilities to support the customers throughout the development cycle. 

In June 2022, Avid Bioservices expanded its viral vector focused facility with 53,000 sq. ft. area to address the demand of viral vector production at commercial scale. 

The increasing prevalence of various genetic disorders and target diseases increased funding availability for development of gene therapy, research efforts in the field of viral vector-based cell and gene therapies, and increasing efficacy of viral vectors in delivering gene therapy are fueling growth in the global viral vectors manufacturing market. 

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Challenges 

The ongoing challenge, which is linked with its ability to pass the immune system and high number of doses are some of the limiting factors delaying the success of such therapies. Further, the quality of transgene expression plays another crucial role for the desired clinical effect. The combinatorial factors demand innovations at the R&D scale, which will gain traction in investment from various organizations. 

In June 2022, NSW Government of Australia allocated USD 101.4 million to the commercial facility of viral vector manufacturing. This clearly indicates the need to improve the viral vector-based therapy due to its significant potential to cure multiple indications.?? 

Development Landscape: 

Biotech and pharmaceutical businesses are adopting both organic and inorganic growth strategies to advance their pipeline and gain competitive edge in the market over the peers. 

In April 2022, ProteoNic and NecstGen announced a collaboration, wherein the respective players will utilize their proprietary platforms to advance the AAV and LV viral vector manufacturing technology. 

Till now, only eight viral vector-based gene therapies have been approved by the US FDA, which were developed using three viral vectors- adeno associated virus, lentivirus and herpes simplex virus. 

As of September 2022, over 145 clinical trial studies are going on with over 10,000 patients worldwide. The exploratory pipeline of viral vector-based therapy continues to grow across the indications and targets with promising results. 

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Key players: 

Lonza (Switzerland), Merck (Germany), Oxford BioMedica (UK), CGT Catapult (UK), Cobra Biologics (UK), uniQure (Netherlands), FUJIFILM Diosynth Biotechnologies (US), and Spark Therapeutics (US) 

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Upcoming players: 

TBD 

Regional Analysis: 

North America?is anticipated to capture the highest share of this market over the forecast period (2022-2027), with U.S. accounting for the maximum contribution. Presence of most number of manufacturing facilities and key players, some of the best research universities and an encouraging start-up eco system provides an ideal environment for research leading to more successful assets in pipeline. Macro-economic factors such as large population and growing economy, high prevalence of cancer and infectious diseases, better access to insurance, availability of crowd funding and support from various stakeholders’ fuels US as a commercially attractible market. 

In 2019, the New Jersey Innovation Institute signed an agreement with Pall Corporation to develop a BioPharmaceutical Innovation iLab to help fix the viral vector shortage using continuous manufacturing. 

Thermo Fisher Scientific opened a cGMP manufacturing facility in Plainville, US which helped double the company’s commercial viral vector capacity?and?meet rising demand for the development and manufacturing of gene therapies and vaccines. 

Europe?also remains a favourable region on par with the North American region. Presence of highly skilled researchers, well-developed R&D ecosystem, support from government agencies and regulatory bodies are the major driving factors in Europe. 

In 2021, Yposkesi announced that its bioproduction project has been selected for the French government’s “Plan de Relance” initiative, which is an economic stimulus package aimed at making the nation’s bioproduction industry strategically more robust and economically resilient is investing USD6 million in its “Boost” project to develop a new generation 1000-L, GMP platform with optimized manufacturing and control processes for efficient viral vector production from the thawing of cells up to the aseptic filling of the end product. 

Asia-Pacific?region is expected to pick up pace over the next few years due to favourable regulatory climate, increasing investments to drive market access in key markets such as Japan, China, Australia, Singapore and India. The market is focusing on Asia-Pacific as a destination for outsourcing and trying to gain foothold through mergers, collaborations, and strategic acquisitions. 

In 2022, National Cancer Center Japan and GenScript ProBio entered into research collaboration agreement for a plasmid and lentiviral vector CMC development to develop plasmid and lentiviral vector for cell therapy to aim on FDA acceptance of IND applications. 

In 2022, VectorBuilder, a CDMO announced an investment of USD 500m for China viral vector plant. The campus will include 30 production suites designed to manufacture lentivirus, plasmids, messenger RNA (mRNA), adeno-associated virus (AAV), cell lines and other types of viral and non-viral vectors. 

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Viral Vectors And Plasmid DNA Manufacturing Market overview by recent opportunities, growth size, regional analysis and forecasts to 2031 | Genelux Corporation, Kaneka Eurogentec S.A., Lonza Group AG

Global Viral Vectors And Plasmid DNA Manufacturing Market report from Global Insight Services is the single authoritative source of intelligence on Viral Vectors And Plasmid DNA Manufacturing Market. The report will provide you with analysis of impact of latest market disruptions such as Russia-Ukraine war and Covid-19 on the market. Report provides qualitative analysis of the market using various frameworks such as Porters’ and PESTLE analysis. Report includes in-depth segmentation and market size data by categories, product types, applications, and geographies. Report also includes comprehensive analysis of key issues, trends and drivers, restraints and challenges, competitive landscape, as well as recent events such as M&A activities in the market.

A viral vector is a virus that has been genetically modified to carry a foreign gene into a cell. The foreign gene may encode a protein that confers a new property to the cell, such as resistance to a particular drug. Alternatively, the foreign gene may be a piece of DNA that the researcher wishes to insert into the cell’s genome.

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Key Trends

The key trends in viral vectors and plasmid DNA manufacturing technology are:

1. Increasing use of viral vectors and plasmid DNA for gene therapy and vaccine development

2. Improvements in vector design and manufacturing processes

4. Decreasing costs of viral vectors and plasmid DNA

Key Drivers

There are several key drivers of the Viral Vectors and Plasmid DNA Manufacturing market. One of the most important drivers is the increasing demand for gene and cell therapies. Gene therapies are becoming more prevalent as treatments for a variety of conditions, including cancer, genetic disorders, and infectious diseases. In addition, cell therapies are being developed for a variety of applications, including regenerative medicine and immunotherapy.

Key Segments

By Vector Type

Adenovirus

Retrovirus

By Workflow

Upstream Manufacturing

Downstream Manufacturing

By Application

Gene Therapy

Cell Therapy

By End-Use

Pharmaceutical & Biopharmaceutical Companies

Research Institutes

By Region

North AmericaThe U.S.

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Key Players

Genelux Corporation

Kaneka Eurogentec S.A.

Lonza Group AG

MaxCyte, Inc.

Merck KGaA

Novasep Inc.

Vector Biolabs

Vigene Biosciences, Inc.

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Viral Vectors And Plasmid DNA Manufacturing Market Is Expected To Grow Swiftly By 2028

The global viral vectors and plasmid DNA manufacturing market size is expected to reach USD 8.6 billion by 2028, according to a new report by Grand View Research, Inc. The market is expected to expand at a CAGR of 18.8% from 2021 to 2028. The robust pipeline for gene therapies and viral-vector-based vaccines has primarily driven the market.

Amidst the COVID-19 pandemic, the demand for viral vectors has rapidly increased especially in vaccinology. This led to expanding manufacturing capabilities by operating players to meet the growing demand. The application of these vectors in vaccine development has witnessed significant growth in 2020.

Also, an increase in the number of gene therapy-based discovery programs initiated by biotechnology and pharmaceutical companies is expected to drive the demand for scalable production of gene therapy vectors. Owing to this, several private and public agencies are providing funds to accelerate advancements in the manufacturing processes for viral vectors.

Besides, the implementation of single-use technology can lead to significant savings in capital, operating costs, materials, and labor. The use of this equipment will enhance efficiency and improve flexibility, leading to high yields of the final product. Thus, advancements in single-use technology directly impact revenue growth in this space.

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Viral Vectors And Plasmid DNA Manufacturing Market Report Highlights

The Adeno Associated Virus (AAV) segment accounted for the significant revenue share in 2020. High usage and promising results in gene therapy clinical trials have boosted its adoption

Moreover, several biopharma companies are offering their viral vector platform for the development of AAV-based gene therapy products, thereby driving the segment

The downstream processing segment dominated the market in terms of revenue share. This can be attributed to the availability of advanced purification products

Owing to the rising demand for cost-effective and scalable manufacturing processes, companies are involved in the development of the upstream cell culture processes

This is anticipated to result in the notable growth of the upstream processing segment

The vaccinology segment dominated the market in terms of revenue share in 2020

The SARS-COV-2 pandemic has supplemented the use of vectors in this segment

With the active engagement of the research community in the R&D of advanced therapies, research institutes captured the maximum revenue share in the market

The initiation of several R&D programs by pharmaceutical and biopharmaceutical companies to combat the COVID-19 crisis would further propel market growth

A rapidly growing pipeline of advanced therapy products for various cancer types has led to lucrative revenue generation in the cancer segment

North America maintained its dominance in 2020 owing to the high number of entities engaged in offering products and services for viral vector manufacturing in the U.S.

Furthermore, the remarkable success of viral vector-based Kymriah, Yescarta, and ZOLGENSMA in the U.S. has also contributed to regional dominance

In Asia Pacific, the market is projected to witness the fastest growth rate owing to industrialization and clinical transformation of gene therapy in the region

Companies continue to make focused attempts to expand their manufacturing facilities as well as service portfolio to maintain their market presence

Viral Vectors And Plasmid DNA Manufacturing Market Segmentation

Grand View Research has segmented the global viral vectors and plasmid DNA manufacturing market on the basis of vector type, workflow, application, end use, disease, and region:

Viral Vectors & Plasmid DNA Manufacturing Vector Type Outlook (Revenue, USD Million, 2017 – 2028)

Adeno Associated Virus (AAV)

Lentivirus

Adenovirus

Retrovirus

Plasmid DNA

Others

Viral Vectors & Plasmid DNA Manufacturing Workflow Outlook (Revenue, USD Million, 2017 – 2028)

Upstream Processing

Downstream Processing

Vector Amplification & Expansion

Vector Recovery/Harvesting

Purification

Fill-finish

Viral Vectors & Plasmid DNA Manufacturing Application Outlook (Revenue, USD Million, 2017 – 2028)

Antisense & RNAi

Gene Therapy

Cell Therapy

Vaccinology

Research Applications

Viral Vectors & Plasmid DNA Manufacturing End-use Outlook (Revenue, USD Million, 2017 – 2028)

Pharmaceutical and Biopharmaceutical Companies

Research Institutes

Viral Vectors & Plasmid DNA Manufacturing Disease Outlook (Revenue, USD Million, 2017 – 2028)

Cancer

Genetic Disorders

Infectious Diseases

Others

Viral Vectors & Plasmid DNA Manufacturing Regional Outlook (Revenue, USD Million, 2017 – 2028)

North America

Europe

Asia Pacific

Latin America

Middle East & Africa

U.S.

Canada

Germany

France

Italy

Spain

U.K.

China

India

Japan

South Korea

Brazil

Mexico

South Africa

Saudi Arabia

List of Key Players of Viral Vectors And Plasmid DNA Manufacturing Market

Merck KGaA

Lonza

FUJIFILM Diosynth Biotechnologies

Cobra Biologics

Thermo Fisher Scientific

Waisman Biomanufacturing

Genezen laboratories

YPOSKESI

Advanced BioScience Laboratories, Inc. (ABL)

Novasep Holdings S.A.S.

Orgenesis Biotech Israel Ltd

Vigene Biosciences Inc.

General electric company (GE Healthcare)

CEVEC. pharmaceuticals GMBH

Batavia Biosciences

Biovion Oy

Wuxi Apptec Co Ltd

VGXI Inc.

Catalent Inc.

Miltenyi Biotec GmbH

SIRION Biotech GmbH

Virovek Incorporation

BioNTech IMFS GmbH

VIVEbiotech S.L.

Creative Biogene

Vibalogics BmbH

Takara Bio Inc.

Cell and Gene Therapy Catapult Bluebird Bio Inc.

Addgene Inc.

Aldevron LLC

Astellas Pharma Inc.

BioMarin Pharmaceutical

RegenxBio, Inc.

About Grand View Research

Grand View Research, Inc. is a U.S. based market research and consulting company, registered in the State of California and headquartered in San Francisco. The company provides syndicated research reports, customized research reports, and consulting services. To help clients make informed business decisions, we offer market intelligence studies ensuring relevant and fact-based research across a range of industries, from technology to chemicals, materials and healthcare.

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Pharmaceutical Contract Development and Manufacturing Market By Service [Pharmaceutical Manufacturing Services (API, FDF), Drug Development Services, Biologics Development], End User [Big & Generic Pharmaceutical Companies] – Global Forecast to 2027

The Pharmaceutical Contract Development and Manufacturing Market is expected to grow at a CAGR of 6.5% from 2020 to 2027 to reach $134.23 billion by 2027. The complex structure for manufacturing pharmaceuticals, increasing investments in pharmaceutical R&D, growing outsourcing of clinical trials, and the outbreak of the COVID-19 pandemic are some of the major drivers for the growth of this market. In addition, the rising demand for generic medicines & biologics, growing demand for cell & gene therapies, and increasing pharmaceutical outsourcing support the growth of this market. However, service quality & IPR issues, lack of skilled professionals, and introduction of serialization are the factors expected to hinder the growth of the pharmaceutical contract development and manufacturing market during the forecast period.  

COVID-19 Impact on the Pharmaceutical Contract Development and Manufacturing Market      

The recent outbreak of COVID-19 has impacted the healthcare market. The pharmaceutical contract development and manufacturing industry has experienced a positive impact due to this pandemic. The outbreak has catalyzed the demand for pharmaceuticals and has stirred the development of corona-related vaccines, antiviral vaccines, antibody therapy, and various pharmaceutical products. This has urged pharmaceutical organizations to hire contract development and manufacturing organizations for pharmaceutical drug development & manufacturing to sustain their business.

The demand for both high quality and high volume CGMP drug substance and drug product manufacturing services has soared, particularly for CDMOs able to support a wide range of COVID vaccine technologies and, to a lesser extent, therapeutic monoclonal antibody products.

Most pharmaceutical companies, CROs, and research institutes are working together to translate research into effective pharmaceutical products. For instance, in August 2020, Catalent Inc. (U.S.) signed an agreement with AstraZeneca PLC (U.K.) to expand manufacturing support for the University of Oxford’s adenovirus vector-based COVID-19 vaccine AZD1222. In September 2020, Thermo Fisher Scientific Inc. (U.S.) partnered with Inovio Pharmaceuticals, Inc. (U.S.) to manufacture INOVIO's DNA COVID-19 vaccine candidate INO-4800 and to enhance the commercial production of INO-4800.

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Increasing investments in the pharmaceutical R&D support the market growth

The pharmaceutical industry is largely driven by scientific discovery and development, in conjunction with toxicological and clinical experience. Also, healthcare R&D activities have significantly increased with rising funding from various government organizations. This funding is mainly driven by rising health care concerns, complexities in clinical trials, and drug failure in early-phase studies.

Governments in developed and developing nations are offering to fund the propagation of biotechnology and biopharmaceutical research. For instance, the Indian government launched 'Pharma Vision 2020' to increase the production capacities of biopharmaceuticals by reducing the approval time for new facilities. Also, the government decided in favor of 100% foreign direct investment in the pharmaceutical industry, which is expected to increase investments in R&D activities. Similarly, in the U.S., the National Institute of Health (NIH) collaborated with 11 biopharmaceutical companies to launch the Partnership for Accelerating Cancer Therapies (PACT) to develop immunotherapy for cancers. The program involved a total investment of USD 215 million.

Further, pharmaceutical companies have also increased their spending on R&D. The extent of pharmaceutical R&D spending serves as an important metric to show a company’s commitment to finding new drugs. At present, the global pharmaceutical industry has the second-highest R&D intensity, i.e. expenditure as a share of any sector's sales measures. Thus, the increasing investments from the government for pharmaceutical R&D is likely to boost outsourcing, thereby accelerating pharmaceutical contract development & manufacturing market growth.

Growing consolidation in the market, an ongoing trend

Due to growing pressure on leading pharmaceutical players, complex drug development process, growing number of patents expiring, increasing R&D costs, and the increasing prevalence of chronic diseases are some of the factors making outsourcing essential.

CDMOs offer the convenience of time and cost due to the inherent nature of dealing with a single entity. The relationship also creates opportunities for the pharmaceutical CDMOs to sell more services to the same customer and locking in products at earlier stages of their life cycles.

Due to the growing pressure on the industry’s leading players to follow stringent regulatory timelines and lack of human clinical trial data, pharmaceutical giants are entering into collaborations, partnerships, and agreements to jointly broaden their services offered across all drug development & pharmaceutical manufacturing processes:

In June 2020, Catalent Inc. (U.S.) collaborated with Moderna, Inc. (U.S.) for large-scale, commercial fill-finish manufacturing of Moderna’s mRNA-based COVID-19 vaccine candidate (mRNA-1273).

In April 2020, ICON plc (Ireland) agreed with Pfizer Inc. (U.S.) to supply drug and device development and commercialization services.

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Key Findings in the Pharmaceutical Contract Development and Manufacturing Market Study:

Pharmaceutical manufacturing services generated a large proportion of revenue compared to other services

The large share of this segment is mainly attributed to the use of advanced technologies & manufacturing skills, the growing need to reduce manufacturing cost, the requirement for high-quality bulk manufacturing, and the growing demand for generic drugs.

Pharmaceutical API contract manufacturing services are estimated to account for the largest share of the pharmaceutical contract manufacturing services market in 2020

The need for the reduction in the cost of production of APIs, growing number of initiatives undertaken by pharmaceutical companies, increasing investments in API manufacturing services, and growing need to reduce the time required for the drug development process are expected to drive the growth of the pharmaceutical API contract manufacturing services segment.

In 2020, the big pharmaceutical companies segment to dominate pharmaceutical contract development and manufacturing market

The major share of this segment is primarily attributed to the growing prevalence of various infectious diseases, growing need for state-of-the-art processes & production technologies, and the rising cost of clinical trials and early development studies.

Asia-Pacific: Fastest growing regional market

In 2020, North America is estimated to command the largest share of the pharmaceutical contract development and manufacturing market, followed by Europe, Asia-Pacific, Latin America, and the Middle East & Africa. However, Asia-Pacific will be the fastest-growing regional market due to the growing manufacturing sector, favorable government regulations, increasing emphasis on off-patent drugs, and highly skilled workforce in the region. In addition, the increase in outsourcing activities in countries like India and China due to lower costs and availability of qualified healthcare professionals are the other key factors propelling the growth of the Asia-Pacific pharmaceutical contract development and manufacturing market.

Key Players

The report includes a competitive landscape based on an extensive assessment of the key strategic developments adopted by leading market participants in the industry over the past four years. The key players profiled in the pharmaceutical contract development and manufacturing market report are Thermo Fisher Scientific Inc. (U.S.), Catalent Inc. (U.S.),  PPD Inc. (U.S.), Lonza Group Ltd (Switzerland), Recipharm AB (Sweden), Vetter Pharma-Fertigung GmbH & Co. KG  (Germany), AbbVie Inc. (U.S.), Synoes Health, Inc. (U.S.), Piramal Enterprises Limited (India), Almac Group (U.K.), Albany Molecular Research Inc. (U.S.), Fareva Holding SA (France), and Jubilant Life Sciences Limited (India).

Scope of the Report:

Pharmaceutical Contract Development and Manufacturing Market, by Service

Pharmaceutical Manufacturing Services

Drug Development Services

Biologics Manufacturing Services

Pharmaceutical API Manufacturing Services

Pharmaceutical FDF Manufacturing Services

Parenteral/Injectable Manufacturing Services

Tablet Manufacturing Services

Capsule Manufacturing Services

Oral Liquid Manufacturing Services

Other Formulations Manufacturing Services

Biologics API Manufacturing Services

Biologics API Manufacturing Services

Pharmaceutical Contract Development and Manufacturing Market, by End User

Big Pharmaceutical Companies

Small and Med-Size Pharmaceutical Companies

Generic Pharmaceutical Companies

Pharmaceutical Contract Development and Manufacturing Market, by Geography

North America

Europe

Asia-Pacific (APAC)

Latin America

Middle East & Africa

U.S.

Canada

Germany

U.K.

France

Italy

Spain

Rest of Europe (RoE)

China

Japan

India

Rest of APAC (RoAPAC)

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Viral Vector and Plasmid DNA Manufacturing Market

Market Overview

The Global "Viral Vector and Plasmid DNA Manufacturing Market" are expected to grow at a high CAGR of 18.8% during the forecasting period (2021-2028).

 The viral vector is referred to as the tool for delivering genetic material into cells. The modified viral vector is used as viral vectors in gene therapy. Plasmid DNA is a bacterial smaller, circular, and extrachromosomal DNA used in different molecular genetic research such as gene therapy, gene transfer, and recombinant DNA technology due to its self-replication property. A gene of interest is transferred into the target cell for studying the function or expression of a gene.

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Market Dynamics:

The market is driven by the increasing demand for viral vectors and plasmid DNA manufacturing for developing DNA vaccines, gene therapy, immunotherapy, and others. There are growing viral vectors & plasmid DNA due to their advantages such as high transfection efficiency, effective gene delivery, and stable gene expression. There is an increase in the number of clinical studies examining the viral vectors' efficacy and safety and plasmid DNA.

 There is an increase in the contract manufacturing business launch for viral vectors and plasmid DNA manufacturing. For instance, in December 2019, Helixmith Co., Ltd. and Genopis had launched the contract manufacturing business for plasmid DNA production. The company would establish additional smaller-scale reactors (60-300 L, 6-30 L) with feasibility runs and start a small-volume production service. Genopis is equipped with the right technologies and quality systems.

 Several companies are entering into a collaboration with several organizations to manufacture viral vectors and plasmid DNA. For instance, in June 2020, Oxford Biomedica plc had entered into a collaboration agreement with the Vaccines Manufacturing and Innovation Centre (VMIC), a not-for-profit organization established to provide the UK’s first strategic vaccine development and advanced manufacturing capability. This five-year agreement would involve the organizations working collaboratively to enable the manufacture of viral vector-based vaccines, contributing to a rapid increase in the United Kingdom domestic capacity for this specialized vaccine manufacturing field. Under the terms of the agreement, VMIC would provide manufacturing equipment for Oxford Biomedica to equip two new GMP manufacturing suites within Oxford Biomedica’s new 7,800 m2 commercial manufacturing center, Oxbox, located in Oxford, United Kingdom.

  Segment Analysis

The global viral vector and plasmid DNA manufacturing market is segmented on the product type as the plasmid DNA, viral vector, and non-viral vector. The viral vector segment accounts for the highest market growth due to the increasing penetration of the viral vectors for targeted delivery, efficient transduction, and controlled gene expression. There is an increase in the viral vectors' usage due to their efficiency in delivering genes into the target cells and protecting the new genes from degradation. Different types of viral vectors such as retrovirus, lentivirus, adenovirus, adeno-associated virus, and herpes simplex virus are used for transferring the nucleic acids into the genetic makeup of cells. Out of these viral vectors, adenovirus and retrovirus are widely used worldwide as these viral vectors have the integration ability with large transgenes and easy production at high titers.

 Several companies are focusing on expanding the manufacturing facilities for the viral vectors to meet the increasing demand. For instance, in May 2019, Thermo Fisher Scientific Inc. had opened its new $90 million viral vector contract development and manufacturing organization (CDMO) site in Lexington, MA. The 50,000-square-foot facility would support the development, testing, and manufacture of viral vectors essential for advancing gene and cell therapies globally.

   Further, the market is also classified based on cancer, genetic disorder, infectious disease, and other diseases. The cancer segment accounts for the highest market share of XX% in 2019 due to the higher usage of the viral vector and plasmid DNA for delivering the anti-cancer genes. Several biotechnology and pharmaceutical companies are examining the viral vectors or plasmid DNA encoding a therapeutic gene, often an immunomodulatory or suicide gene, in the various cancer gene therapy trials. Clinical studies have demonstrated that the injection of a plasmid DNA encoding a cytokine gene has a significant antitumor effect. There is increasing research and development activities for gene therapies and other advanced cell therapies to treat various cancers. The increase in the approval of the viral vector and plasmid DNA-based therapies shall stimulate market growth. For instance, the lentiviral vector-based CAR-T cell therapies' approval for treating Acute Lymphoblastic Leukemia (ALL) and large B cell lymphoma.

 Geographical Presentation

By region, the global viral vector and plasmid DNA manufacturing market is segmented into North America, South America, Europe, Asia-Pacific, Middle-East, and Africa. Among all of the regions, North America dominated the global viral vector and plasmid DNA manufacturing market and is expected to grow at the highest CAGR during the forecasted period due to the increasing number of clinical studies for evaluating the use of the viral vector and plasmid DNA for the treatment of the genetic disorders, cancer, and infectious diseases. The increase in the approval of advanced cell therapies shall stimulate market growth. There is growing research and development activities of gene therapies. Several companies, institutes, associations, and foundations raise the investment and funding to develop gene therapies. The growing initiatives by the Food and Drug Administration (FDA) for improving the regulatory support for cell and gene therapy shall boost the demand for viral vector and plasmid DNA manufacturing.

 The Asia Pacific is expected to witness positive market growth due to the growing clinical transformation and industrialization of advanced therapies medicinal products, including gene therapy manufacturing. There is a presence of several companies manufacturing the viral vector and plasmid DNA. Contract manufacturers are providing several services for viral vector and plasmid DNA manufacturing. There is growing adoption of advanced technologies for manufacturing viral vectors and plasmid DNA.

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 Competitive Analysis

The global viral vector and plasmid DNA manufacturing market are highly competitive with several international and local markets. Product diversification, revenue generation, and opportunities intensify the market competition. Brammer Bio, Cobra Biologics, Cell and Gene Therapy Catapult, FinVector Vision Therapies, Fujifilm Diosynth Biotechnologies, SIRION Biotech, Merck KGaA Inc., Thermo Fisher Scientific, and Uniqure NV are the leading market players with significant market share.

 The major players enter into collaborations, acquisitions, mergers, and licensing activities to increase their market presence. For instance, in August 2019, FUJIFILM Corporation had acquired the Biogen (Denmark) Manufacturing ApS, a large-scale biologics manufacturing site located in Hillerød near Copenhagen, Denmark, from Biogen. The Hillerød Manufacturing site would be the fourth biopharmaceutical manufacturing site of FUJIFILM Diosynth Biotechnologies, a Fujifilm subsidiary, and a leading Contract Development and Manufacturing Organization (CDMO) with expertise in the development and manufacture of biologics and advanced therapies.

 In March 2019, Merck had entered into the non-binding Memorandum of Understanding with Chinese biotech company GenScript for a strategic alliance focusing on a plasmid and viral vector manufacturing. The manufacturing of high-quality plasmids and viral vectors would help in the commercialization of cell and gene therapy. This collaboration would help the company accelerate the industrialization and commercialization of cell and gene therapy in China. Merck would provide GenScript with comprehensive products, training, consulting services covering process design, facility concept design, and quality management system set-up from lab development to large-scale GMP manufacturing.

 In December 2017, MilliporeSigma had entered into the commercial supply agreement to manufacture viral vectors for bluebird bio, Inc., of Cambridge, Massachusetts, for its use in potentially transformative gene therapies. MilliporeSigma would manufacture lentiviral vectors for bluebird bio's drug products developed to treat various rare genetic diseases under the agreement's terms. This contract builds upon MilliporeSigma's deep experience producing viral vectors for gene therapy from clinical to commercial scale.

 In June 2014, Applied Genetic Technologies Corporation had entered into the collaboration with the Sigma-Aldrich Corporation to provide gene therapy manufacturing services to companies developing gene-based therapies. Under the terms of the agreement, the two companies will co-market AGTC's proprietary HAVE manufacturing method with SAFC's cGMP manufacturing capabilities. AGTC will assist clients in engineering AAV-based vectors and the associated helper viruses for HAVE-based manufacturing activities. SAFC will manufacture AAV vectors with the HAVE system to either support initial research or by cGMP requirements to support clinical trial development and eventual commercial production.

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[marketglobalresearchreport]

Global Viral Vector Vaccines Market Size, Share, Trends, Growth, Demand and Estimates to 2027

The recently Published Report titled Global Viral Vector Vaccines Market Size, Share, Trends, Growth, Demand and Estimates to 2027 by Axel Reports offers a comprehensive picture of the market from the global view point as well as a descriptive analysis with detailed segmentation, complete research and development history, latest news, offering a forecast and statistic in terms of revenue during the forecast period from 2021-2027. The report covers a comprehensive analysis of key segments, recent trends, competitive landscape, and key factors playing a substantial role in the market are detailed in the report. The report helps vendors and manufacturers to understand the change in the market dynamics over the years.

Get Sample Copy of this Report with the Latest Market Trend and COVID-19 Impact: https://axelreports.com/request-sample/55827

Global Market Segmentation by Top Key-Players: Advanced Bioscience Laboratories Creative Biogene Boehringer Ingelheim Sanofi Brammer Bio Pfizer GE Healthcare

NOTE: Consumer behaviour has changed within all sectors of the society amid the COVID-19 pandemic. Industries on the other hand will have to restructure their strategies in order to adjust with the changing market requirements. This report offers you an analysis of the COVID-19 impact on the Viral Vector Vaccines market and will help you in strategising your business as per the new industry norms.

Report offers: 1. Insights into the intact market structure, scope, profitability, and potential. 2. Precise assessment of market size, share, demand, and sales volume. 3. Authentic estimations for revenue generation and Viral Vector Vaccines Market development. 4. Thorough study of Viral Vector Vaccines Market companies including organizational and financial status. 5. Perception of crucial market segments including, forecast study. 6. Acumen of upcoming opportunities and potential threats and risks in the market.

Market segments by Types of, the report covers- Adenovirus Fowlpox Virus Attenuated Yellow Fever Vaccinia Virus Vectors Others Market segments by Applications of, the report covers- Hospitals Clinics Others

The report diversifies the global geographical expanse of the market into five prominent regions as:

North America (United States, Canada and Mexico)

Europe (Germany, France, United Kingdom, Russia, Italy, and Rest of Europe)

Asia-Pacific (China, Japan, Korea, India, Southeast Asia, and Australia)

South America (Brazil, Argentina, Colombia, and Rest of South America)

Middle East & Africa (Saudi Arabia, UAE, Egypt, South Africa, and Rest of Middle East & Africa)

Key Elements Discussed In The Report: The report then discusses important dynamics on the business drivers that have a major impact on the performance are given in the report. The business drivers are important to the business operations and financial results of the industry. All the drivers are determined in the research study using market analysis. The report is comprehensive coverage of the existing and potential markets along with their assessment of their competitive position in the changing market scenario. It scrutinizes in-depth global market trends and outlook coupled with the factors driving the global Viral Vector Vaccines market, as well as those hindering it.

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Moreover, the report throws light on the pinpoint analysis of global Viral Vector Vaccines market dynamics. It also measures the sustainable trends and platforms which are the basic roots behind the market growth. With the help of SWOT and Porter’s five analysis, the market has been deeply analyzed. Consumer behavior is assessed with respect to current and upcoming trends. The report takes a detailed note of the major industrial events in past years. These events include several operational business decisions, innovations, mergers, collaborations, major investments, etc.

Customization of the Report: This report can be customized to meet the client’s requirements. Please connect with our sales team ( sales@axelreports.com), who will ensure that you get a report that suits your needs. You can also get in touch with our executives on +18488639402 to share your research requirements.

ABOUT Axel Reports:

Axel Reports has the most comprehensive collection of market research products and services available on the web. We deliver reports from virtually all major publications and refresh our list regularly to provide you with immediate online access to the world’s most extensive and up-to-date archive of professional insights into global markets, companies, goods, and patterns.

Contact: Axel Reports Akansha G (Knowledge Partner) Office No- P 221 Pune, Maharashtra 411060 Phone: US +18488639402 Web: https://axelreports.com/

[leonfrancisblog]

Viral Vector and Vaccine Market is Rising exponentially at a Healthy CAGR of 14.50% During the Anticipated Period of 2020 to 2027| Novasep, MerckKGaA, Cobra Biologics Ltd., uniQure N.V., Waisman, Creative-Biogene

Viral Vector and Vaccine Market size is expected grow at a compound annual growth rate of 14.50% in the forecast period of 2020 to 2027 due to the growing prevalence of disease such as cancer, cardiac diseases, HIV and hemophilia which has raised the need for the development of therapies using viral vector and is primarily driving the market growth rate. Beside this, the presence of untapped medical sector in some regions and rising government initiatives for R&D sector of healthcare sector will produce lucrative opportunities for the growth of the viral vector and vaccine market.

High transfection efficiency, effective gene delivery and stable gene expression have made viral vectors preferred choice for gene transfer and it is evident by increasing clinical trials on viral vector medicated gene therapy. Increasing prevalence of disease such as cardiac diseases, cancer, HIV, Hemophilia has raised need for the development of therapies using viral vector whereas advancement in technology to manufacture viral vector is the key factor driving market growth. Moreover rising adoption of viral vectors by biopharmaceutical industries and increasing cost effective treatments are factor propelling market demand whereas lack of skilled professionals and high cost are factors restraining market growth. However untapped medical sector in some regions and increasing government initiatives for R&D sector of healthcare sector will produce lucrative opportunities in coming years.

Global Viral Vector & Vaccine Market By Type (Adenovirus, Retrovirus, Plasmid DNA, AAV, Lentivirus, Others), Workflow Upstream Processing, Downstream Processing, Application (Antisense & RNAi, Gene Therapy, Cell Therapy, Vaccinology), Disease (Cancer, Genetic Disorders, Infectious Diseases, Others), End Use (Pharmaceutical and Biopharmaceutical Companies, Research Institutes), Country (U.S., Canada, Mexico, Germany, Italy, U.K., France, Spain, Netherlands, Belgium, Switzerland, Turkey, Russia, Rest of Europe, Japan, China, India, South Korea, Australia, Singapore, Malaysia, Thailand, Indonesia, Philippines, Rest of Asia-Pacific, Brazil, Argentina, Rest of South America, South Africa, Saudi Arabia, UAE, Egypt, Israel, Rest of Middle East & Africa) Industry Trends and Forecast to 2027 This viral vector & vaccine market report provides details of new recent developments, trade regulations, import export analysis, production analysis, value chain optimization, market share, impact of domestic and localised market players, analyses opportunities in terms of emerging revenue pockets, changes in market regulations, strategic market growth analysis, market size, category market growths, application niches and dominance, product approvals, product launches, geographic expansions, technological innovations in the market. To gain more info on viral vector & vaccine market contact us for an Analyst Brief, our team will help you take an informed market decision to achieve market growth.

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Viral Vector and Vaccine Market Scope:

Viral vector and vaccine market is segmented on the basis of countries into the U.S., Canada and Mexico in North America, Germany, France, U.K., Netherlands, Switzerland, Belgium, Russia, Italy, Spain, Turkey, Rest of Europe in Europe, China, Japan, India, South Korea, Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, Rest of Asia-Pacific (APAC) in the Asia-Pacific (APAC), Saudi Arabia, U.A.E, South Africa, Egypt, Israel, Rest of Middle East and Africa (MEA) as a part of Middle East and Africa(MEA), Brazil, Argentina and Rest of South America as part of South America.

All country based analysis of viral vector and vaccine market is further analyzed based on maximum granularity into further segmentation. Based on type, the viral vector & vaccine market is segmented into adenovirus, retrovirus, plasmid DNA, AAV, lentivirus, and others. Based on workflow, the viral vector and vaccine market is segmented into upstream processing, downstream processing. Based on application, the viral vector & vaccine market is segmented into antisense & RNAi, gene therapy, cell therapy, and vaccinology. On the basis of disease, viral vector and vaccine market is segmented into cancer, genetic disorders, infectious diseases, and others. Viral vector and vaccine market has also been segmented based on end use into pharmaceutical and biopharmaceutical companies, and research institutes.

Viral vectors are one of the promising tools that are used for gene therapy and vaccines. Viral vector-based vaccines can improve immunogenicity without an adjuvant and encourage a robust cytotoxic T lymphocyte response to eradicate virus infected cells.

Key Market Competitors Covered in the report:

Novasep, MerckKGaA, Cobra Biologics Ltd., uniQure N.V., Waisman, Creative-Biogene, Aldevron, Addgene, Oxford Biomedica, Thermo Fisher Scientific Inc, Cell Therapy Catapult Limited Eurogentec, Fujifilm, Spark Therapeutics Inc. DBMR analysts understand competitive strengths and provide competitive analysis for each competitor separately.

Key Pointers Covered in the Viral Vector Market Size:

Market New Sales Volumes

Market Replacement Sales Volumes

Market Installed Base

Market By Brands

Market Procedure Volumes

Market Product Price Analysis

Market Healthcare Outcomes

Market Cost of Care Analysis

Market Regulatory Framework and Changes

Prices and Reimbursement Analysis

Market Shares in Different Regions

Recent Developments for Market Competitors

Market Upcoming Applications

Market Innovators Study

MAJOR TOC OF THE REPORT:

Chapter One: Viral Vector and Vaccine Market Overview

Chapter Two: Manufacturers Profiles

Chapter Three: Viral Vector and Vaccine Market Competition, by Players

Chapter Four: Viral Vector and Vaccine Market Size by Regions

Chapter Five: Viral Vector and Vaccine Market Revenue by Countries

Chapter Six: Viral Vector and Vaccine Market Revenue by Type

Chapter Seven: Viral Vector and Vaccine Market Revenue by Application

Chapter Eight: Viral Vector and Vaccine Market Revenue by Industries

Chapter Nine: Viral Vector and Vaccine Market Revenue by Deployment Model

Chapter Ten: Viral Vector and Vaccine Market Revenue by End User

Get Detail TOC@ https://www.databridgemarketresearch.com/toc/?dbmr=global-viral-vector-and-vaccine-market  

Key Report Highlights:

Comprehensive pricing analysis based on different product types and regional segments

Market size data in terms of revenue and sales volume

Deep insights about regulatory and investment scenarios of the global Information Rights Management Market

Analysis of market effect factors and their impact on the forecast and outlook of the global Information Rights Management Market

The detailed assessment of the vendor landscape and leading companies to help understand the level of competition in the global Information Rights Management Market

A roadmap of growth opportunities available in the Global Information Rights Management Market with the identification of key factors

The exhaustive analysis of various trends of the Global Information Rights Management Market to help identify market developments

Key Questions Answered in Report:

What is the key to the Information Rights Management Market?

What will the Information Rights Management Market Demand and what will be Growth?

What are the latest opportunities for Information Rights Management Market in the future?

What are the strengths of the key players?

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Data Bridge Market Research set forth itself as an unconventional and neoteric Market research and consulting firm with unparalleled level of resilience and integrated approaches. We are determined to unearth the best market opportunities and foster efficient information for your business to thrive in the market

Contact:

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[opedguy]

EU Plays Games with Russia’s Sputnik V

LOS ANGELES (OnlineColumnist.com), March 10, 2021.--Playing politics with human lives in middle of Covid-19 global pandemic, the European Union’s Amsterdam-based European Medicines Agency [EMA] said there wasn’t enough date to approve Russia’s Sputnik V vaccine, the first Covid-19 vaccine to hit the market Nov. 11, 2020.  Authorizing three vaccines including Pfizer-BioNTech, Moderna and AstraZeneca-Oxford.  Sputnik V beat Pfizer’s vaccine by a month, when it was approved the U.S. Food and Drug Administration [FDA] Dec. 11, 2020, followed a week later by Moderna.  EMA board Chief Christa Wirthumer-Hoche told an Austrian radio talk show that she would urge the EMA to reject Sputnik V pending more review of its safety and effectiveness.  Moscow reacted harshly to Wirthumer-Hoche’s public statement.  Wirthhumer-Hoche knows that Sputnik V was reviews by the British Medical Journal Lancet.

           Lancet completed its review of Sputnik V, evaluating the vaccine’s efficacy at 92% and verified its safety protocol for the two shot vaccine.  Unlike the Pfizer and Moderna mRNA  vaccines, Sputnik V was DNA  adenovirus vaccine the say type created to treat the deadly hemorrhagic fever  Elola virus successfully. While the FDA and Centers for Disease Control Prevention [CDC] would have liked more Phase 3 data, Russia’s Gamaleya Institute has a track record making safe and effective vaccines, something they did again with Sputnik V for Covid-19.  “We demand a public apology from EMA’s Crista Wirthumer-Hoche for her negative comments . . .. (which) raise serious question about possible political interference in the ongoing EMA review,” Tweeted the developers of Sputnik-V.  After approved by Lancet, there’s no excuse to doubt the vaccine’s safety and effectiveness.

]           If there’s any question about the safety or efficacy of vaccines, it’s with Pfizer  Moderna’s new mRNA technology, never used before, creating unusual side effects in many people taking the vaccines.  Sputnik V, like the Astra Zeneca-Oxford and Johnson & Johnson vaccines, makes use of old, tried-and-true vaccine technology to create an immune response to the novel coronavirus spike-proteins, that penetrates human cells.  Sputnik V is unique among other adenovirus vaccines because its uses two different vaccine vectors, one in the first dose and another in the second dose to provide maximum immunity. At a time when the world  suffers with 118,630,045 Covid-19 cases and 2,631,996 deaths, world heath agencies should do everything possible to get safe-and-effective vaccines to market. Hungary, Slovakia and Czech Republic already approved Sputnik V.

           Kremlin spokesman Dmitry Peskov called Wirthumer-Hoche’s statement “regrettable and inappropriate,” saying Sputnik V was already in the EU and in 46 other countries, having been reviewed by the British Medical Journal Lancet. Peskov said Gamaleya Pharmaceuticals was in the process of licensing Sputnik V to Swiss Pharmaceutical company Adienne for manufacture in Italy, Brazil and Argentna.  Peskov smells a rat with the EMA’s refusal to approve Sputnik V for emergency use authorization.  Peskov noted that the EU has sanctioned Kremlin officials for treatment of 44-year-old Russian dissident Alexi Navalny who was recently sent to prison on a parole violation. Delaying approval of Sputnik V for political reasons violates every known principle of global health, where adversaries put aside their differenced for the betterment of civilization and humanity.

           EMA noted in response to Russia’s request for approval of Sputnik V that EU countries have “access to effectively evaluate medicines at the same time and ensures centralized safety monitoring across their life cycle,” something already afforded to the EMA by Lancet.  Sputnik V has been widely demanded by countries around the planet not only because it costs one-half of other vaccines because its 92% effective and completely safe. Whatever the issues and EMA, it’s looking more political that based on science.  Sputnik V has been used successfully in numerous countries attesting to its safety and effectiveness.  German Chancellor Angela Merkel said Feb. 26 she would not take AstraZenea-Oxford’s vaccine because it lacked enough safety data infuriating British Prime Minister Boris Johnson.  Merkel knows that AstraZeneca-Oxford’s vaccine has been proven safe and effective.

           Contradicting EMA about Sputnik V, Thomas Mertens, head o a German expert panel evaluating vaccines gave his approval to Sputnik V.  “This is a good vaccine, which looks like it will be approved in the EU at some point.  The Russian researchers are very experienced in vaccines,” Mertens said, who heads STIKO, Germany’s panel for approving vaccines. Mertens statements on Sputnik V puts added pressure on EMA to grant emergency use authorization, especially given that vaccine shortages have delayed the global effort to combat the Covid-19 pandemic.  Moscow’s head of its RDIF sovereign wealth fund confirmed its in negotiations with Spain, France and Germany to develop agreements to start manufacturing Sputnik V under Switzerland’s Adienne Pharmaceuticals.  EMA needs to stop playing politics and approve Sputnik V for emergency use.

About the Author

John M. Curtis writes politically neutral commentary analyzing spin in national and global news. He’s editor of OnlineColumnist.com and author of Dodging The Bullet and Operation Charisma.

[rohinic123-blog]

COVID-19 Vaccine Pipeline Market Future Growth Analysis, Demand and Supply Analysis and COVID19 Impact Analysis Covered 2020 - 2030

COVID-19 Vaccine Pipeline: Introduction

COVID-19 is an infectious disease caused by the coronavirus. COVID-19 began its outbreak in Wuhan, China in December 2019. The World Health Organization (WHO) declared COVID-19 as Public Health Emergency of International Concern on January 30, 2020.

COVID-19 is spreading rapidly across the globe and almost every country has reported notable number of cases as well as death due to this this infection

Till date, the U.S. has recorded highest number of COVID-19 cases with count of more than one million active cases and more than 60,000 deaths. In Europe, more than 1.4 million active cases of COVID-19 have been reported as of April 30, 2020 with Italy being the worst affected country in the region. Italy has reported around 200,000 Covid-19 cases and more than 27,000 deaths.

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The most common symptoms associated with COVID-19 are fever, dry cough, tiredness, aches and pains, nasal congestion, sore throat; and diarrhea. In the beginning stages of the COVID-19 infections, the symptoms are very mild. According to the WHO, 1 out of every 5 COVID-19 patients becomes seriously ill and faces breathing problem.

No perfect treatment or cure is available to treat the disease till date and lots of research and development activities are being carried out by leading players operating in the biopharmaceutical market place and all are expecting some positive outcomes very soon

The WHO has facilitated and accelerated efforts on the development of COVID-19 vaccine on such a scale that was not ever seen before in history

Healthcare experts estimate that the fast tracked vaccine development process could take around 12 to 18 months to successfully reach the market

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COVID-19 Vaccine Pipeline: Clinical Trial Phase 2/3

The University of Melbourne and Murdoch Children’s Research Institute are testing Bacillus Calmette-Guerin (BCG) live-attenuated vaccine for COVID-19. According to a research article published in MedRxIV in April 2020, the people in countries with BCG vaccination program at childhood are less virulent to COVID-19 than that of people in countries without BCG vaccination program.

Researchers at Radboud University Medical Center (The Netherlands) have launched the phase-3 BCG-CORONA trial on March 31, 2020 and plan to enroll 1,500 healthcare workers to receive the BCG vaccine or placebo

Clinical Trial Phase 2

China-based biotech company Sinovac Biotech is developing COVID-19 vaccine candidate PiCoVacc. The company has claimed to have successfully tested the vaccine against COVID-19 in monkeys. The company is in talks with the World Health Organization to launch the phase-3 clinical trials in the region where the COVID-19 cases are rapidly spreading.

Massachusetts-based biotech company Moderna has developed the mRNA-1273 COVID-19 vaccine candidate. The mRNA-1273 is currently in phase-2 stage of clinical trial pipeline study and the USFDA has awarded the fast track designation for this candidate.

The China National Pharmaceutical Group (Sinopharm) is developing the inactivated vaccine candidate against COVID-19. The vaccine candidate has received the approval from the National Medical Products Administration and is currently in phase-2 of clinical trial pipeline studies.

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Clinical Trial Phase 1

China-based biotechnology company CanSino Biologics has used the adenovirus type 5 vector (Ad5) to develop novel COVID-19 vaccine. The preliminary safety data from phase-1 clinical trials is positive and it allowed the company to plan for phase-2 clinical trial studies.

The Oxford university’s Jenner Institute in collaboration with AstraZeneca is developing the ‘ChAdOx1 nCoV-19' coronavirus vaccine. The vaccine has shown the positive results on six rhesus macaque monkeys in March 2020. After the positive results from the initial trials on macaque monkey, the Oxford’s team is planning to test the vaccine on 6,000 people by the end of May 2020. If the clinical trials are successful in humans, then few million doses of the vaccine would be available by the end of September 2020.

The Serum Institute of India has planned to collaborate with Oxford University for the manufacture of vaccine if clinical trials are successful. The Serum Institute of India can produce 5 million doses of vaccine per month for the first 6 months and after that, the company can scale up to 10 million doses per month.

Inovio Pharmaceuticals is developing DNA vaccine INO-4800 against COVID-19. The Inovio Pharmaceuticals and the International Vaccine Institute (IVI) in association with Korea National Institute of Health (KNIH) are conducting phase 1/2 clinical trials in Korea.

Pfizer Inc. and BioNTech have collaborated to develop COVID-19 vaccine candidate BNT 162. The BNT-62 is currently under phase 1/2 clinical trial study. The human trials are also started with BNT 162 in the U.S.

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Pre-clinical

A lot of companies are developing COVID-19 vaccine candidates in preclinical studies. Some of companies having vaccine candidates in preclinical studies are Novavax, CureVac, Generex Biotechnology, Vaxart, Medicago, Takis Biotech, Altimmune, and Johnson and Johnson.

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[aditi-us]

Global Gene Therapy Market is Expected to Thrive at a CAGR of 33.3% Forecast period 2017-2023

A Comprehensive research study conducted by KD Market Insights on "Gene Therapy Market by Vector Type (Viral Vector and Non-viral Vector), Gene Type (Antigen, Cytokine, Tumor Suppressor, Suicide, Deficiency, Growth Factors, Receptors, and Others), and Applications (Oncological Disorders, Rare Diseases, Cardiovascular Diseases, Neurological Disorders, Infectious Disease, and Other Diseases) - Global Opportunity Analysis and Industry Forecast, 2017-2023" report offers extensive and highly detailed historical, current and future market trends in the global and regional/market. The Gene Therapy Market report includes market size, growth drivers, barriers, opportunities, trends and other information which helps to find new opportunities in this market for the growth of the business through new technologies and developments. The Global Gene Therapy Market was valued at $584 million in 2016, and is estimated to reach $4,402 million by 2023, registering a CAGR of 33.3% from 2017 to 2023. Gene therapy is a technique that involves the delivery of nucleic acid polymers into a patient’s cells as a drug to treat diseases. It fixes a genetic problem at its source. The process involves modifying the protein either to change the genetic expression or to correct a mutation. The emergence of this technology meets the rise in needs for better diagnostics and targeted therapy tools. For instance, genetic engineering can be used to modify physical appearance, metabolism, physical capabilities, and mental abilities such as memory and intelligence. In addition, it is also used for infertility treatment. Gene therapy offers a ray of hope for patients, who either have no treatment options or show no benefits with drugs currently available. The ongoing success has strongly supported upcoming researches and has carved ways for enhancement of gene therapy. Request for Sample @ https://www.kdmarketinsights.com/sample/3544 The gene therapy market is a widely expanding field in the pharmaceutical industry with new opportunities. This has piqued the interests of venture capitalists to explore this market and its commercial potential. Major factors that drive the growth of this market include high demands for DNA vaccines to treat genetic diseases, targeted drug delivery, and high incidence of genetic disorders. However, the stringent regulatory approval process for gene therapy and the high costs of gene therapy drugs are expected to hinder the growth of the market. The global gene therapy market is segmented based on vector type, gene type, application, and geography. Based on vector type, it is categorized into viral vector and non-viral vector. Viral vector is further segmented into retroviruses, lentiviruses, adenoviruses, adeno associated virus, herpes simplex virus, poxvirus, vaccinia virus, and others. Non-viral vector is further categorized into naked/plasmid vectors, gene gun, electroporation, lipofection, and others. Based on gene type, the market is classified into antigen, cytokine, tumor suppressor, suicide, deficiency, growth factors, receptors, and others. Based on application, the market is divided into oncological disorders, rare diseases, cardiovascular diseases, neurological disorders, infectious disease, and other diseases. Based on region, it is analyzed across North America, Europe, Asia-Pacific, and LAMEA. KEY MARKET BENEFITS - This report offers a detailed quantitative analysis of the current market trends from 2016 to 2023 to identify the prevailing opportunities. - The market estimations provided in this report are based on comprehensive analysis of the key developments in the industry. - In-depth analysis based on geography facilitates in analyzing the regional market to assist in strategic business planning. - The development strategies adopted by key manufacturers are enlisted in the report to understand the competitive scenario of the market. KEY MARKET SEGMENTS By Vector Type - Viral vector - - Retroviruses - - Lentiviruses - - Adenoviruses - - Adeno Associated Virus - - Herpes Simplex Virus - - Poxvirus - - Vaccinia Virus - - Others - Non-viral vector - - Naked/Plasmid Vectors - - Gene Gun - - Electroporation - - Lipofection - - Others By Gene Type - Antigen - Cytokine - Tumor Suppressor - Suicide - Deficiency - Growth factors - Receptors - Others By Application - Oncological Disorders - Rare Diseases - Cardiovascular Diseases - Neurological Disorders - Infectious disease - Other Diseases By Region - North America - - U.S. - - Canada - - Mexico - Europe - - Germany - - UK - - France - - Spain - - Italy - - Rest of Europe - Asia-Pacific - - Japan - - China - - India - - South Korea - - Rest of Asia-Pacific - LAMEA - - Brazil - - Republic of South Africa - - Rest of LAMEA KEY PLAYERS PROFILED - Novartis - Kite Pharma, Inc. - GlaxoSmithKline PLC - Spark Therapeutics Inc. - Bluebird bio Inc. - Genethon - Transgene SA - Applied Genetic Technologies Corporation - Oxford BioMedica - NewLink Genetics Corp. Browse Full Report with TOC @ https://www.kdmarketinsights.com/product/gene-therapy-market-amr Table of Contents: CHAPTER 1 INTRODUCTION 1.1. Report description 1.2. Key benefits 1.3. Key market segments 1.4. Research methodology 1.4.1. Secondary research 1.4.2. Primary research 1.4.3. Analyst tools and models CHAPTER 2: EXECUTIVE SUMMARY 2.1. CXO perspective CHAPTER 3: MARKET OVERVIEW 3.1. Market definition and scope 3.2. Key findings 3.2.1. Top investment pockets 3.2.2. Top winning strategies 3.2.2.1. Top winning strategies, by year, 2015-2017* 3.2.2.2. Top winning strategies, by development, 2015-2017* (%) 3.2.2.3. Top winning strategies, by company, 2015-2017* 3.3. Top player positioning, 2016 3.4. Porters five forces analysis 3.5. Market dynamics 3.5.1. Drivers 3.5.1.1. High investment for R&D activities pertaining to gene therapy 3.5.1.2. Increase in prevalence of cancer 3.5.1.3. Growth in awareness regarding gene therapy 3.5.2. Restraints 3.5.2.1. High cost associated with gene therapies 3.5.2.2. Unwanted immune responses 3.5.3. Opportunity 3.5.3.1. Untapped potential for emerging markets CHAPTER 4: GENE THERAPY MARKET, BY VECTOR TYPE 4.1. Overview 4.1.1. Market size and forecast 4.2. Viral vectors 4.2.1. Key market trends 4.2.2. Key growth factors and opportunities 4.2.3. Market size and forecast 4.2.4. Market Analysis by country 4.2.5. Adenovirus 4.2.6. Lentivirus 4.2.7. Retrovirus 4.2.8. Adeno-associated virus 4.2.9. Herpes simplex virus 4.2.10. Poxvirus 4.2.11. Vaccinia virus 4.2.12. Others 4.3. Nonviral techniques 4.3.1. Key market trends 4.3.2. Key growth factors and opportunities 4.3.3. Market size and forecast 4.3.4. Market Analysis by country 4.3.5. Naked plasmid vector 4.3.6. Gene gun 4.3.7. Electroporation 4.3.8. Lipofection 4.3.9. Others CHAPTER 5: GENE THERAPY MARKET, BY GENE TYPE 5.1. Overview 5.1.1. Market size and forecast 5.2. Antigen 5.2.1. Market size and forecast 5.2.2. Market size and forecast by country 5.3. Cytokine 5.3.1. Market size and forecast 5.3.2. Market Analysis, by country 5.4. Tumor suppressor 5.4.1. Market size and forecast 5.4.2. Market Analysis, by country 5.5. Suicide 5.5.1. Market size and forecast 5.5.2. Market Analysis, by country Continue… Check for Discount @ https://www.kdmarketinsights.com/discount/3544 About Us: KD Market Insights offers a comprehensive database of syndicated research studies, customized reports, and consulting services. These reports are created to help in making smart, instant and crucial decisions based on extensive and in-depth quantitative information, supported by extensive analysis and industry insights. Our dedicated in-house team ensures the reports satisfy the requirement of the client. We aim at providing value service to our clients. Our reports are backed by extensive industry coverage and is made sure to give importance to the specific needs of our clients. The main idea is to enable our clients to make an informed decision, by keeping them and ourselves up to date with the latest trends in the market. Contact Us: KD Market Insights 150 State Street, Albany, New York, USA 12207 +1 (518) 300-1215 Email: sales@kdmarketinsights.com Website: www.kdmarketinsights.com  

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Pharmaceutical Contract Development and Manufacturing Market By Service [Pharmaceutical Manufacturing Services (API, FDF), Drug Development Services, Biologics Development], End User [Big & Generic Pharmaceutical Companies] – Global Forecast to 2027

The Pharmaceutical Contract Development and Manufacturing Market is expected to grow at a CAGR of 6.5% from 2020 to 2027 to reach $134.23 billion by 2027. The complex structure for manufacturing pharmaceuticals, increasing investments in pharmaceutical R&D, growing outsourcing of clinical trials, and the outbreak of the COVID-19 pandemic are some of the major drivers for the growth of this market. In addition, the rising demand for generic medicines & biologics, growing demand for cell & gene therapies, and increasing pharmaceutical outsourcing support the growth of this market. However, service quality & IPR issues, lack of skilled professionals, and introduction of serialization are the factors expected to hinder the growth of the pharmaceutical contract development and manufacturing market during the forecast period.  

COVID-19 Impact on the Pharmaceutical Contract Development and Manufacturing Market      

The recent outbreak of COVID-19 has impacted the healthcare market. The pharmaceutical contract development and manufacturing industry has experienced a positive impact due to this pandemic. The outbreak has catalyzed the demand for pharmaceuticals and has stirred the development of corona-related vaccines, antiviral vaccines, antibody therapy, and various pharmaceutical products. This has urged pharmaceutical organizations to hire contract development and manufacturing organizations for pharmaceutical drug development & manufacturing to sustain their business.

The demand for both high quality and high volume CGMP drug substance and drug product manufacturing services has soared, particularly for CDMOs able to support a wide range of COVID vaccine technologies and, to a lesser extent, therapeutic monoclonal antibody products.

Most pharmaceutical companies, CROs, and research institutes are working together to translate research into effective pharmaceutical products. For instance, in August 2020, Catalent Inc. (U.S.) signed an agreement with AstraZeneca PLC (U.K.) to expand manufacturing support for the University of Oxford’s adenovirus vector-based COVID-19 vaccine AZD1222. In September 2020, Thermo Fisher Scientific Inc. (U.S.) partnered with Inovio Pharmaceuticals, Inc. (U.S.) to manufacture INOVIO's DNA COVID-19 vaccine candidate INO-4800 and to enhance the commercial production of INO-4800.

                                                              Click here to: Get Free Sample Pages of this Report

Increasing investments in the pharmaceutical R&D support the market growth

The pharmaceutical industry is largely driven by scientific discovery and development, in conjunction with toxicological and clinical experience. Also, healthcare R&D activities have significantly increased with rising funding from various government organizations. This funding is mainly driven by rising health care concerns, complexities in clinical trials, and drug failure in early-phase studies.

Governments in developed and developing nations are offering to fund the propagation of biotechnology and biopharmaceutical research. For instance, the Indian government launched 'Pharma Vision 2020' to increase the production capacities of biopharmaceuticals by reducing the approval time for new facilities. Also, the government decided in favor of 100% foreign direct investment in the pharmaceutical industry, which is expected to increase investments in R&D activities. Similarly, in the U.S., the National Institute of Health (NIH) collaborated with 11 biopharmaceutical companies to launch the Partnership for Accelerating Cancer Therapies (PACT) to develop immunotherapy for cancers. The program involved a total investment of USD 215 million.

Further, pharmaceutical companies have also increased their spending on R&D. The extent of pharmaceutical R&D spending serves as an important metric to show a company’s commitment to finding new drugs. At present, the global pharmaceutical industry has the second-highest R&D intensity, i.e. expenditure as a share of any sector's sales measures. Thus, the increasing investments from the government for pharmaceutical R&D is likely to boost outsourcing, thereby accelerating pharmaceutical contract development & manufacturing market growth.

Growing consolidation in the market, an ongoing trend

Due to growing pressure on leading pharmaceutical players, complex drug development process, growing number of patents expiring, increasing R&D costs, and the increasing prevalence of chronic diseases are some of the factors making outsourcing essential.

CDMOs offer the convenience of time and cost due to the inherent nature of dealing with a single entity. The relationship also creates opportunities for the pharmaceutical CDMOs to sell more services to the same customer and locking in products at earlier stages of their life cycles.

Due to the growing pressure on the industry’s leading players to follow stringent regulatory timelines and lack of human clinical trial data, pharmaceutical giants are entering into collaborations, partnerships, and agreements to jointly broaden their services offered across all drug development & pharmaceutical manufacturing processes:

In June 2020, Catalent Inc. (U.S.) collaborated with Moderna, Inc. (U.S.) for large-scale, commercial fill-finish manufacturing of Moderna’s mRNA-based COVID-19 vaccine candidate (mRNA-1273).

In April 2020, ICON plc (Ireland) agreed with Pfizer Inc. (U.S.) to supply drug and device development and commercialization services.

                                              Click here to: Get a Free Request Sample Copy of this report

Key Findings in the Pharmaceutical Contract Development and Manufacturing Market Study:

Pharmaceutical manufacturing services generated a large proportion of revenue compared to other services

The large share of this segment is mainly attributed to the use of advanced technologies & manufacturing skills, the growing need to reduce manufacturing cost, the requirement for high-quality bulk manufacturing, and the growing demand for generic drugs.

Pharmaceutical API contract manufacturing services are estimated to account for the largest share of the pharmaceutical contract manufacturing services market in 2020

The need for the reduction in the cost of production of APIs, growing number of initiatives undertaken by pharmaceutical companies, increasing investments in API manufacturing services, and growing need to reduce the time required for the drug development process are expected to drive the growth of the pharmaceutical API contract manufacturing services segment.

In 2020, the big pharmaceutical companies segment to dominate pharmaceutical contract development and manufacturing market

The major share of this segment is primarily attributed to the growing prevalence of various infectious diseases, growing need for state-of-the-art processes & production technologies, and the rising cost of clinical trials and early development studies.

Asia-Pacific: Fastest growing regional market

In 2020, North America is estimated to command the largest share of the pharmaceutical contract development and manufacturing market, followed by Europe, Asia-Pacific, Latin America, and the Middle East & Africa. However, Asia-Pacific will be the fastest-growing regional market due to the growing manufacturing sector, favorable government regulations, increasing emphasis on off-patent drugs, and highly skilled workforce in the region. In addition, the increase in outsourcing activities in countries like India and China due to lower costs and availability of qualified healthcare professionals are the other key factors propelling the growth of the Asia-Pacific pharmaceutical contract development and manufacturing market.

Key Players

The report includes a competitive landscape based on an extensive assessment of the key strategic developments adopted by leading market participants in the industry over the past four years. The key players profiled in the pharmaceutical contract development and manufacturing market report are Thermo Fisher Scientific Inc. (U.S.), Catalent Inc. (U.S.),  PPD Inc. (U.S.), Lonza Group Ltd (Switzerland), Recipharm AB (Sweden), Vetter Pharma-Fertigung GmbH & Co. KG  (Germany), AbbVie Inc. (U.S.), Synoes Health, Inc. (U.S.), Piramal Enterprises Limited (India), Almac Group (U.K.), Albany Molecular Research Inc. (U.S.), Fareva Holding SA (France), and Jubilant Life Sciences Limited (India).

Scope of the Report:

Pharmaceutical Contract Development and Manufacturing Market, by Service

Pharmaceutical Manufacturing Services

Drug Development Services

Biologics Manufacturing Services

Pharmaceutical API Manufacturing Services

Pharmaceutical FDF Manufacturing Services

Parenteral/Injectable Manufacturing Services

Tablet Manufacturing Services

Capsule Manufacturing Services

Oral Liquid Manufacturing Services

Other Formulations Manufacturing Services

Biologics API Manufacturing Services

Biologics API Manufacturing Services

Pharmaceutical Contract Development and Manufacturing Market, by End User

Big Pharmaceutical Companies

Small and Med-Size Pharmaceutical Companies

Generic Pharmaceutical Companies

Pharmaceutical Contract Development and Manufacturing Market, by Geography

North America

Europe

Asia-Pacific (APAC)

Latin America

Middle East & Africa

U.S.

Canada

Germany

U.K.

France

Italy

Spain

Rest of Europe (RoE)

China

Japan

India

Rest of APAC (RoAPAC)

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Polyinosinic Acid Market By Manufacturers, Type and Applications, Status and Forecast, 2016-2024

Global Polyinosinic Acid Market: Overview

Polyinosinic acid used as a model RNA, is composed of a polynucleotide chain. It consists entirely of inosinic acid residues. Polyinosinic acid is made from polycytidylic acid. It is a homopolymer of inosine used with polycytidylic acid to form a double stranded homopolymer. This acts as a major effector of the immune response against viral pathogens. Polyinosinic acid is primarily used in the form of sodium salt to simulate viral infections.

Browse Market Research Report: http://www.transparencymarketresearch.com/polyinosinic-acid-market.html

Polyinosinic acid (abbreviated as Poly I:C) along with polycytidylic acid acts as an immunostimulant. It is known to interact with toll-like receptor 3, which is expressed in the membrane of B-cells, macrophages, and dendritic cells. Polyinosinic acid enhances delivery of adenovirus vectors. It is used primarily in pharmaceuticals, health care, and medical sectors. Polyinosinic acid is employed as a potent adjuvant in the medical sector to enhance the specific anti-tumor immune responses against a peptide-based vaccine. Growth in pharmaceutical and health care sectors is expected to boost the demand for polyinosinic acid in the next few years. Polyinosinic acid is anticipated to penetrate the market rapidly due to the various research and development activities conducted by several companies and medical organizations. It is not available widely since it is medical product; however, demand for polyinosinic acid is high due to its anti-tumor immune responses. Polyinosinic acid requires ionic strength to maintain the double strand structure. In order to prevent denaturation, polyinosinic acid is reconstituted in solutions with physiological salt concentrations. Furthermore, it may require heating and cooling to achieve re-annealing.

Asia Pacific held the major share of the polyinosinic acid market in 2015, led by the high growth of pharmaceutical and medical sectors. Demand for polyinosinic acid is also high in Europe and North America. The U.S., Germany, China, India, and Japan accounted for key share of the polyinosinic market in 2015. Polyinosinic acid is highly produced and consumed in these countries due to the increase in population, high standard of living, rise in number of diseases among the people, and expansion in pharmaceutical and medical sectors. Middle East & Africa constituted smaller share of the polyinosinic market in 2015; however, demand for polyinosinic acid is anticipated to rise at a rapid pace in the region in the next few years. Optimization of physicochemical properties of polyinosinic acid has led to generation of derivatives that have increased stability in body fluids (such as polyICLC), or reduced toxicity through reduced stability in body fluids. This is estimated to boost the polyinosinic acid market during the forecast period.

Get accurate market forecast and analysis on the Polyinosinic Acid market. Request a sample to stay abreast on the key trends impacting this market @ http://www.transparencymarketresearch.com/sample/sample.php?flag=B&rep_id=22208

Key manufacturers of polyinosinic acid across the globe include Biotain Pharma Co. Ltd., N&R Bio Industries Inc., Beijing Isomersyn Technology Co. Ltd., Hubei XinyuanShun Chemical Co. Ltd., and Hangzhou Dingyan Chem. Co. Ltd.

The report offers a comprehensive evaluation of the market. It does so via in-depth qualitative insights, historical data, and verifiable projections about market size. The projections featured in the report have been derived using proven research methodologies and assumptions. By doing so, the research report serves as a repository of analysis and information for every facet of the market, including but not limited to: Regional markets, technology, types, and applications.

About Us

Transparency Market Research (TMR) is a global market intelligence company providing business information reports and services. The company’s exclusive blend of quantitative forecasting and trend analysis provides forward-looking insight for thousands of decision makers. TMR’s experienced team of analysts, researchers, and consultants use proprietary data sources and various tools and techniques to gather and analyze information.

TMR’s data repository is continuously updated and revised by a team of research experts so that it always reflects the latest trends and information. With extensive research and analysis capabilities, Transparency Market Research employs rigorous primary and secondary research techniques to develop distinctive data sets and research material for business reports.

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Pharmaceutical Contract Development and Manufacturing Market By Service [Pharmaceutical Manufacturing Services (API, FDF), Drug Development Services, Biologics Development], End User [Big & Generic Pharmaceutical Companies] – Global Forecast to 2027

The Pharmaceutical Contract Development and Manufacturing Market is expected to grow at a CAGR of 6.5% from 2020 to 2027 to reach $134.23 billion by 2027. The complex structure for manufacturing pharmaceuticals, increasing investments in pharmaceutical R&D, growing outsourcing of clinical trials, and the outbreak of the COVID-19 pandemic are some of the major drivers for the growth of this market. In addition, the rising demand for generic medicines & biologics, growing demand for cell & gene therapies, and increasing pharmaceutical outsourcing support the growth of this market. However, service quality & IPR issues, lack of skilled professionals, and introduction of serialization are the factors expected to hinder the growth of the pharmaceutical contract development and manufacturing market during the forecast period.  

COVID-19 Impact on the Pharmaceutical Contract Development and Manufacturing Market      

The recent outbreak of COVID-19 has impacted the healthcare market. The pharmaceutical contract development and manufacturing industry has experienced a positive impact due to this pandemic. The outbreak has catalyzed the demand for pharmaceuticals and has stirred the development of corona-related vaccines, antiviral vaccines, antibody therapy, and various pharmaceutical products. This has urged pharmaceutical organizations to hire contract development and manufacturing organizations for pharmaceutical drug development & manufacturing to sustain their business.

The demand for both high quality and high volume CGMP drug substance and drug product manufacturing services has soared, particularly for CDMOs able to support a wide range of COVID vaccine technologies and, to a lesser extent, therapeutic monoclonal antibody products.

Most pharmaceutical companies, CROs, and research institutes are working together to translate research into effective pharmaceutical products. For instance, in August 2020, Catalent Inc. (U.S.) signed an agreement with AstraZeneca PLC (U.K.) to expand manufacturing support for the University of Oxford’s adenovirus vector-based COVID-19 vaccine AZD1222. In September 2020, Thermo Fisher Scientific Inc. (U.S.) partnered with Inovio Pharmaceuticals, Inc. (U.S.) to manufacture INOVIO's DNA COVID-19 vaccine candidate INO-4800 and to enhance the commercial production of INO-4800.

                                                              Click here to: Get Free Sample Pages of this Report

Increasing investments in the pharmaceutical R&D support the market growth

The pharmaceutical industry is largely driven by scientific discovery and development, in conjunction with toxicological and clinical experience. Also, healthcare R&D activities have significantly increased with rising funding from various government organizations. This funding is mainly driven by rising health care concerns, complexities in clinical trials, and drug failure in early-phase studies.

Governments in developed and developing nations are offering to fund the propagation of biotechnology and biopharmaceutical research. For instance, the Indian government launched 'Pharma Vision 2020' to increase the production capacities of biopharmaceuticals by reducing the approval time for new facilities. Also, the government decided in favor of 100% foreign direct investment in the pharmaceutical industry, which is expected to increase investments in R&D activities. Similarly, in the U.S., the National Institute of Health (NIH) collaborated with 11 biopharmaceutical companies to launch the Partnership for Accelerating Cancer Therapies (PACT) to develop immunotherapy for cancers. The program involved a total investment of USD 215 million.

Further, pharmaceutical companies have also increased their spending on R&D. The extent of pharmaceutical R&D spending serves as an important metric to show a company’s commitment to finding new drugs. At present, the global pharmaceutical industry has the second-highest R&D intensity, i.e. expenditure as a share of any sector's sales measures. Thus, the increasing investments from the government for pharmaceutical R&D is likely to boost outsourcing, thereby accelerating pharmaceutical contract development & manufacturing market growth.

Growing consolidation in the market, an ongoing trend

Due to growing pressure on leading pharmaceutical players, complex drug development process, growing number of patents expiring, increasing R&D costs, and the increasing prevalence of chronic diseases are some of the factors making outsourcing essential.

CDMOs offer the convenience of time and cost due to the inherent nature of dealing with a single entity. The relationship also creates opportunities for the pharmaceutical CDMOs to sell more services to the same customer and locking in products at earlier stages of their life cycles.

Due to the growing pressure on the industry’s leading players to follow stringent regulatory timelines and lack of human clinical trial data, pharmaceutical giants are entering into collaborations, partnerships, and agreements to jointly broaden their services offered across all drug development & pharmaceutical manufacturing processes:

In June 2020, Catalent Inc. (U.S.) collaborated with Moderna, Inc. (U.S.) for large-scale, commercial fill-finish manufacturing of Moderna’s mRNA-based COVID-19 vaccine candidate (mRNA-1273).

In April 2020, ICON plc (Ireland) agreed with Pfizer Inc. (U.S.) to supply drug and device development and commercialization services.

                                              Click here to: Get a Free Request Sample Copy of this report

Key Findings in the Pharmaceutical Contract Development and Manufacturing Market Study:

Pharmaceutical manufacturing services generated a large proportion of revenue compared to other services

The large share of this segment is mainly attributed to the use of advanced technologies & manufacturing skills, the growing need to reduce manufacturing cost, the requirement for high-quality bulk manufacturing, and the growing demand for generic drugs.

Pharmaceutical API contract manufacturing services are estimated to account for the largest share of the pharmaceutical contract manufacturing services market in 2020

The need for the reduction in the cost of production of APIs, growing number of initiatives undertaken by pharmaceutical companies, increasing investments in API manufacturing services, and growing need to reduce the time required for the drug development process are expected to drive the growth of the pharmaceutical API contract manufacturing services segment.

In 2020, the big pharmaceutical companies segment to dominate pharmaceutical contract development and manufacturing market

The major share of this segment is primarily attributed to the growing prevalence of various infectious diseases, growing need for state-of-the-art processes & production technologies, and the rising cost of clinical trials and early development studies.

Asia-Pacific: Fastest growing regional market

In 2020, North America is estimated to command the largest share of the pharmaceutical contract development and manufacturing market, followed by Europe, Asia-Pacific, Latin America, and the Middle East & Africa. However, Asia-Pacific will be the fastest-growing regional market due to the growing manufacturing sector, favorable government regulations, increasing emphasis on off-patent drugs, and highly skilled workforce in the region. In addition, the increase in outsourcing activities in countries like India and China due to lower costs and availability of qualified healthcare professionals are the other key factors propelling the growth of the Asia-Pacific pharmaceutical contract development and manufacturing market.

Key Players

The report includes a competitive landscape based on an extensive assessment of the key strategic developments adopted by leading market participants in the industry over the past four years. The key players profiled in the pharmaceutical contract development and manufacturing market report are Thermo Fisher Scientific Inc. (U.S.), Catalent Inc. (U.S.),  PPD Inc. (U.S.), Lonza Group Ltd (Switzerland), Recipharm AB (Sweden), Vetter Pharma-Fertigung GmbH & Co. KG  (Germany), AbbVie Inc. (U.S.), Synoes Health, Inc. (U.S.), Piramal Enterprises Limited (India), Almac Group (U.K.), Albany Molecular Research Inc. (U.S.), Fareva Holding SA (France), and Jubilant Life Sciences Limited (India).

Scope of the Report:

Pharmaceutical Contract Development and Manufacturing Market, by Service

Pharmaceutical Manufacturing Services

Drug Development Services

Biologics Manufacturing Services

Pharmaceutical API Manufacturing Services

Pharmaceutical FDF Manufacturing Services

Parenteral/Injectable Manufacturing Services

Tablet Manufacturing Services

Capsule Manufacturing Services

Oral Liquid Manufacturing Services

Other Formulations Manufacturing Services

Biologics API Manufacturing Services

Biologics API Manufacturing Services

Pharmaceutical Contract Development and Manufacturing Market, by End User

Big Pharmaceutical Companies

Small and Med-Size Pharmaceutical Companies

Generic Pharmaceutical Companies

Pharmaceutical Contract Development and Manufacturing Market, by Geography

North America

Europe

Asia-Pacific (APAC)

Latin America

Middle East & Africa

U.S.

Canada

Germany

U.K.

France

Italy

Spain

Rest of Europe (RoE)

China

Japan

India

Rest of APAC (RoAPAC)