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DRV Clinic by Razvan Vasilas Academy: Master the Art of Aesthetic Medicine

DRV Clinic by Razvan Vasilas Academy is the premier destination for mastering aesthetic medicine. Our comprehensive masterclasses equip medical professionals with the skills and knowledge to deliver safe and effective treatments. Join us to learn the latest techniques and elevate your practice.

[hasnain2112]

Inter Miami CF: South Florida's MLS Team

Founding and Ownership

Inter Miami CF, officially known as Club Internacional de Fútbol Miami, was founded in January 2018. The creation of the team marked a significant moment for soccer in South Florida. The club was brought into existence by a group of influential figures, including David Beckham, Jorge Mas, and Jose Mas. Beckham, a former soccer superstar with a global fan base, took on the role of co-owner and president of football operations. His extensive experience and passion for the sport have been instrumental in shaping the identity and vision of Inter Miami.

Early Years and Stadium

Inter Miami officially joined Major League Soccer (MLS) in 2020, kicking off their inaugural season on March 1st. The team made their debut with great anticipation from fans and the soccer community. Their home matches are held at DRV PNK Stadium, located in Fort Lauderdale, Florida. This state-of-the-art stadium has a capacity of approximately 21,550 spectators, providing an intimate yet vibrant atmosphere for fans. The stadium's naming rights are held by AutoNation, a prominent car dealership chain, reflecting the club's strong ties with local businesses.

Team Identity and Nicknames

Inter Miami is often referred to by their nickname, "The Herons." This moniker was inspired by the Great White Heron, a majestic bird commonly found in the South Florida region. The team's colors—pink, black, and white—are a nod to the vibrant and diverse culture of the area. Fans of the club have also embraced the nickname "Vice City," a reference to the popular video game set in Miami, further highlighting the team's deep connection to the local culture.

Building the Roster

Since its inception, Inter Miami has been focused on building a competitive and dynamic roster. The club's strategy involves a mix of experienced international players and promising young talent. By leveraging Beckham's extensive network and scouting expertise, Inter Miami aims to create a team capable of competing at the highest level in MLS. The club's management is committed to developing a strong foundation for long-term success, both on and off the field.

Challenges and Early Performance

Inter Miami's journey in MLS has been filled with challenges and learning experiences. The team secured their first MLS win in August 2020, defeating Orlando City SC. This victory was a significant milestone, signaling the team's potential and determination. However, the path to consistent success has been demanding, with the team striving to improve and adapt to the competitive nature of the league.

Fan Engagement and Community

Engaging with the local community is a core value for Inter Miami. The club actively participates in various community outreach programs, aiming to inspire and connect with fans of all ages. By hosting events, youth clinics, and charitable initiatives, Inter Miami strives to foster a strong bond with the South Florida community. The fans, known for their passion and loyalty, play a crucial role in creating a vibrant matchday atmosphere.

Future Aspirations

Looking ahead, Inter Miami has ambitious plans for the future. The club is dedicated to reaching new heights in MLS and establishing itself as a dominant force in North American soccer. With a solid foundation and a clear vision, Inter Miami aims to achieve success both domestically and internationally. The management is focused on continuous improvement, strategic signings, and enhancing the overall fan experience.

The Impact of David Beckham

David Beckham's involvement with Inter Miami cannot be overstated. His global stature and influence have brought significant attention to the club. Beckham's hands-on approach and commitment to excellence set a high standard for the entire organization. His vision for Inter Miami goes beyond just winning matches; it encompasses creating a legacy that inspires future generations of soccer players and fans.

Youth Development and Academy

Developing young talent is a priority for Inter Miami. The club has established a comprehensive youth academy system aimed at nurturing and developing promising players from the South Florida region. By providing top-notch coaching, facilities, and opportunities, Inter Miami seeks to create a pipeline of talent that can eventually contribute to the first team. The focus on youth development aligns with the club's long-term vision of sustainability and success.

Partnerships and Collaborations

Inter Miami has forged strategic partnerships and collaborations with various organizations to enhance their operations and reach. These partnerships span across multiple sectors, including sports science, technology, and community engagement. By leveraging these collaborations, Inter Miami aims to stay at the forefront of innovation and continue evolving as a modern soccer club.

Eco-Friendly Initiatives

Inter Miami is committed to sustainability and environmental responsibility. The club has implemented several eco-friendly initiatives to reduce their carbon footprint and promote environmental awareness. These initiatives include energy-efficient stadium operations, recycling programs, and community clean-up events. Inter Miami's dedication to sustainability reflects their broader commitment to being a positive force in the community.

Challenges and Learning Experiences

The journey of establishing a new soccer club in MLS comes with its share of challenges. Inter Miami has faced various hurdles, from building a competitive roster to navigating the complexities of the league. Each challenge has been an opportunity for growth and learning. The management and players are focused on overcoming obstacles and continuously improving to achieve their goals.

Cultural Impact

Inter Miami's presence in South Florida has had a significant cultural impact. The club has become a symbol of unity and pride for the diverse communities in the region. Soccer, being a global sport, has the power to bring people together, and Inter Miami embodies this spirit. The team's matches are a celebration of the rich cultural tapestry that defines South Florida.

Technological Innovations

Inter Miami is leveraging technological innovations to enhance the fan experience and optimize team performance. From advanced analytics to immersive fan engagement platforms, the club is at the cutting edge of sports technology. These innovations not only provide valuable insights for the coaching staff but also create a more engaging and interactive experience for fans.

Merchandise and Branding

Inter Miami's branding and merchandise have quickly become popular among fans. The team's distinctive colors and logo are prominently featured on a wide range of merchandise, from jerseys to accessories. The club's branding efforts extend beyond just visual identity; they represent the spirit and ethos of Inter Miami. Fans proudly wear the team's colors, creating a sense of belonging and unity.

Social Media Presence

In the digital age, social media plays a crucial role in connecting with fans and building a global following. Inter Miami has a strong social media presence, actively engaging with fans through various platforms. The club shares behind-the-scenes content, match highlights, and interactive posts to keep fans informed and entertained. This digital engagement helps strengthen the bond between the club and its supporters.

Future Goals

Inter Miami's future goals are centered around achieving sustained success in MLS and beyond. The club is focused on winning titles, developing talent, and expanding their fan base. With a clear vision and strategic planning, Inter Miami aims to become a benchmark for excellence in North American soccer. The journey is ongoing, and the club is committed to making continuous progress.

Conclusion

Inter Miami CF is more than just a soccer club; it is a symbol of passion, ambition, and community. From its founding by David Beckham and the Mas brothers to its aspirations for future success, Inter Miami embodies the spirit of South Florida. The club's journey is marked by challenges, achievements, and a commitment to excellence. As Inter Miami continues to grow and evolve, it remains dedicated to making a positive impact on and off the field. The future is bright for The Herons, and the journey has only just begun.

[stelladebraa]

Structural Adaptation of Darunavir Analogs Against Primary Resistance Mutations in HIV-1 Protease

HIV-1 protease is one of the prime targets of agents used in antiretroviral therapy against HIV. However, under selective pressure of protease inhibitors, primary mutations at the active site weaken inhibitor binding to confer resistance. Darunavir (DRV) is the most potent HIV-1 protease inhibitor in clinic; resistance is limited, as DRV fits well within the substrate envelope. Nevertheless, resistance is observed due to hydrophobic changes at residues including I50, V82 and I84 that line the S1/S1’ pocket within the active site. Through enzyme inhibition assays and a series of 12 crystal structures, we interrogated susceptibility of DRV and two potent analogs to primary S1’ mutations. The analogs had modifications at the hydrophobic P1’ moiety to better occupy the unexploited space in the S1’ pocket where the primary mutations were located. Considerable losses of potency were observed against protease variants with I84V and I50V mutations for all three inhibitors.

The crystal structures revealed an unexpected conformational change in the flap region of I50V protease bound to the analog with the largest P1’ moiety, indicating interdependency between the S1’ subsite and the flap region. Collective analysis of protease-inhibitor van der Waals (vdW) interactions in the crystal structures using principle component analysis indicated I84V mutation underlying the largest variation in the vdW contacts. Interestingly, the principle components were able to distinguish inhibitor identity and relative potency solely based on vdW interactions of active site residues in the crystal structures. Our results reveal the interplay between inhibitor P1’ moiety and primary S1’ mutations, as well as suggesting a novel method for distinguishing the interdependence of resistance through principle component analyses.

[four4soaring]

One of my favorite #Seuss #quotes4soaring . . . . . #quotestagram #readacrossamerica #readacrossamericaweek #drseussweek #thecatinthehat #instaquote #medico #doctor #nurse #drv #seuss #clinical #quotestoliveby #drseussday #qotd #happybirthdaydrseuss #drseuss #dailyquote #quote #doctor #lifequotes #inspirationalquotes #catinthehat #quotes #quoteoftheday #quotesoftheday #dr via @hashtagexpert (at Summerville, South Carolina) https://www.instagram.com/p/B91FQ8Mljfs/?igshid=t05cddairrt5

[biomedscis]

Exploring Potential Synergism Between Darunavir/Cobicistat and Ribavirin for the Treatment of Covid-19 Patients: A Retrospective Comparison Study: OAJBS Publishers

Exploring Potential Synergism Between Darunavir/Cobicistat and Ribavirin for the Treatment of Covid-19 Patients: A Retrospective Comparison Study by Reem Elajez* in Open Access Journal of Biomedical Science (OAJBS)

Objective: Exploring potential synergistic effect of darunavir/cobicistat (DRV/COBI) plus ribavirin (RBV) in COVID-19 treatment.

Methods: Retrospective, observational comparison study conducted in Qatar. Adult patients with confirmed positive SARSCoV-2 who received either DRV/COBI or DRV/COBI+RBV were included. Primary outcome was time to viral clearance, while secondary outcomes. include clinical improvement (resolution of fever/tachypnea), development of acute respiratory distress syndromes (ARDS) and 28-days all-cause mortality, and incidence of adverse reactions.

Results: Sixty-four patients were included (41 received DRV/COBI and 23 received DRV/COBI+ RBV). Mean age of patients was 48.4±14.6 years with predominant male gender (58/64; 90.6%). Median time from starting therapy till viral clearance was 11 days in DRV/COBI+RBV vs. 16 days in DRV/COBI groups (P=0.295). At day-28, viral clearance was observed in 82.6% (19/23) and 73.2% (30/41) in DRV/COBI+RBV and DRV/COBI groups, respectively (P=0.392). Patients receiving DRV/COBI+RBV did not achieve faster resolution of fever or tachypnea compared to those receiving DRV/COBI. Three patients in DRV/COBI+RBV group developed ARDS, while none in DRV/COBI group. Frequency of hemoglobin drop of ≥2g/dl was significantly higher in DRV/COBI+RBV group than in DRV/COBI group (34.8% vs. 7.9%, P=0.008, respectively).

Conclusion: Use of darunavir/cobicistat plus ribavirin was not associated with faster viral clearance or better clinical outcomes. https://biomedscis.com/fulltext/exploring-potential-synergism-between-darunavir-cobicistat-and-ribavirin-for-the-treatment-of-covid-19-patients-a-retrospective-comparison-study.ID.000262.php

To Know More About Open Access Journal of Biomedical Science Please Visit: Biomedscis

Are Click on: https://Biomedscis.Com/

[neckpaintherapy-blog1]

Ready! Set! Go!

New Post has been published on https://brownfamily-dc.com/product/ready-set-go/

Ready! Set! Go!

OVERVIEW

While there is no daily recommended value (DRV) for dietary fiber, the American Heart Association recommends children consume between 19 g and 31 g per day depending on age. The lack of adequate dietary fiber intake can lead to many digestive problems, such as occasional constipation, gas and bloating. Occasional constipation is a common condition, caused in part by poor diet and lifestyle. The prevalence of refined sugars and carbohydrates and the low presence of fiber in the Western diet has been linked to the slowing of bowel transit time and the alteration of the colon environment. Dietary fiber, which is mostly obtained from plant foods, consists of the indigestible portion of the plant while the sugars, starches and vitamins are broken down into nutrients and absorbed by the intestines. These cell walls of plants are not digested and become the bulk or roughage component of the stool, which help maintain bowel health and regularity.

Ready! Set! Go! is a blend of all-natural fruits and plant extracts for children with occasional constipation. The ingredients in this blend, which include prunes, psyllium husks, and ginger, have been used historically for the relief of occasional constipation and to soothe an achy stomach. Ready! Set! Go! has a pleasant flavor for easy compliance.

Suggested Use:

Children up to 6: 1-3 teaspoons daily as needed or as recommended by your health care professional

Children 6-12: 1-2 tablespoons daily as needed or as recommended by your health care professional

Adults: 2-3 tablespoons daily as needed or as recommended by your health care professional

INGREDIENT BENEFITS

Psyllium Seeds

Several clinical trials have shown psyllium to be superior to other laxatives. A systematic review found psyllium husk to improve overall bowel regularity more effectively than lactulose. Psyllium has been found to be more effective than placebo at increasing stool output and was found to improve symptoms of occasional constipation.

Fig (Ficus carica)

The phytochemical properties of fig’s laxative effect are due to the bulk of seeds and fibers. Fig supplementation also improved most of the symptoms in the patients suffering with functional bowel irregularity, and the fruit has also been shown to support regulation of loose bowels.

Prune (Prunus domestica)

Prunes have 6.1 g of dietary fiber per 100 g, as well as large amounts of phenolic compounds, which may aid in their efficacy for occasional constipation.

#Childrens, #ChildrensConstipation, #Constipation, #Gastrointestinal, #GI, #Gut, #Regularity

[mariebenz]

HIV: Hopeful Results of Doravirine vs Ritonavir-Boosted Darunavir at 96 Weeks

MedicalResearch.com Interview with:

Kathleen Squires MD Director, Division of Infectious Diseases Jefferson University Hospitals and Ming-Tai Lai, PhD Senior Principal Scientist, Biology Discover Merck   MedicalResearch.com: What is the background for this study? What are the main findings?  Dr. Squires: The DRIVE-FORWARD study is a pivotal, randomized, double-blind, Phase 3 study that evaluated the safety and efficacy of doravirine (DOR), a non-nucleoside reverse transcriptase inhibitor (NNRTI) in treatment-naïve adults with HIV-1 infection. Data from week 48 of this trial have previously been presented demonstrating that doravirine met its primary endpoint of non-inferior efficacy compared to ritonavir-boosted darunavir (DRV+r). In addition, at 48 weeks, a secondary endpoint showed that the doravirine-treated group had statistically significant lower levels of fasting LDL-C and non-HDL-C versus the DRV+r group. The data presented at AIDS 2018 are week 96 data from the DRIVE-FORWARD trial. At week 96, the doravirine group demonstrated efficacy of 73.1% compared with 66.0% in the DRV+r group, a treatment difference of 7.1% (95% CI: 0.5, 13.7)  Two participants in the DOR treatment group developed genotypic and phenotypic resistance to DOR through 96 weeks of treatment. The rate of discontinuation of therapy due to adverse events was 1.6 percent in the DOR group and 3.4 percent in the DRV+r group. Doravirine is a late-stage investigational NNRTI for the treatment of HIV-1 infection in treatment-naïve adults and is being evaluated both as a once-daily single-entity tablet in combination with other antiretroviral agents, and as a once-daily fixed-dose combination regimen with lamivudine (3TC) and tenofovir disoproxil fumarate (TDF). Earlier this year, Merck announced that the FDA accepted for review two New Drug Applications (NDAs) for doravirine for the treatment of HIV-1 infection in treatment-naïve adults. The NDAs are based upon the findings at week 48 of two ongoing Phase 3 trials, DRIVE-FORWARD and DRIVE-AHEAD, evaluating the efficacy and safety of doravirine and the fixed-dose combination regimen of DOR/3TC/TDF, respectively. The FDA has set a target action date of October 23, 2018 for both applications. Dr. Lai: This study aimed to characterize the mutant viruses selected in treatment-naïve participants through week 48 from DRIVE-FORWARD and DRIVE-AHEAD, and to assess the impact of selected mutations on non-nucleoside reverse transcriptase inhibitor (NNRTI) susceptibility and viral fitness. All of the seven doravirine (DOR)-resistant mutants are either partially susceptible or susceptible to etravirine. Mutants containing the F227C substitution were shown to be hypersusceptible to some nucleoside reverse transcriptase inhibitors (NRTIs) such as azidothymidine (AZT), tenofovir (TFV), lamivudine (3TC), and MK-8591. Among the 12 participants who developed efavirenz (EFV) resistance, 9 of the EFV-resistant clinical mutants were susceptible to DOR with fold-change Read the full article

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Double Chin Treatment London | DRV Clinic

Say goodbye to your double chin with our non-surgical treatment in London. Experience effective chin fat dissolving injections for a sculpted jawline. Trust DRV Clinic to deliver personalized treatments tailored to your needs, bringing out the best version of you.

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Get the Best Hair Loss Treatment in London | DRV Clinic

Struggling with hair loss? No worries! The DRV Clinic is here for your Hair Loss Treatment in London. Our dedicated team offers compassionate care and advanced treatments to combat hair loss. With our expertise and personalized approach, regain your confidence and youthful appearance. Say goodbye to thinning hair and hello to confidence. Schedule your consultation today and take the first step towards reclaiming your hair and confidence!

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Get Your Dark Circles Treatment Done with DRV Clinic

Get rid of those pesky dark circles under your eyes with top-notch Dark Circles treatment at DRV Clinic in London. Our experts offer personalized solutions to tackle discoloration and puffiness, leaving your under-eye skin looking refreshed and radiant. Using the latest techniques and high-quality products, we ensure effective results and expert care. Trust DRV Clinic for all your dark circles treatment needs in London.