#Dale R Singleton

[elijones94]

🍁🍂 These are snapshots I took on Grandpa’s birthday about four weekends ago. He was very relaxed and comfort. It was the happiest I had seen him in a long time. He passed away this previous weekend doing what he loved: working. Today as our letters to him were being read, my many memories of spending time with him came to me all at once. My two favorites are of him getting a speeding ticket and Jacob was with us and being the kid that I was declared, “This is the last time I go on adventures with Grandpa!” Of course, more adventures with him followed over the years.

Another adventure involved driving the mule of the frozen pond. The ice cracked beneath us, I asked what to do, and Grandpa just said to jump to dry land. One thing I found fascinating about him is that he could file something in his brain and remember it after so many, many years , especially his early childhood. Particularly fascinating, was that he even remembered hearing the radio report that President Harry Truman fired General Douglas MacArthur from his military services. Grandpa was always a natural storyteller, especially when we would all be together at the dinner table. His wisdom and humor will most definitely be missed, but I will forever be thankful for how much Grandpa made a difference in my life and everybody else’s lives as well.

Dale Singleton (1942-2022)

[autistpride]

These books are written "geared towards" adults and older teens. I personally would let my teen read all of these, so I'm not gatekeeping literature, but use your own judgement on what you think is acceptable for your own kid to read.

Nonfictional Books for adults:

All the weight of our dreams by Lydia XZ Brown

Stim: an autistic anthology edited by Lizzie Huxley-Jones

Connecting with Autism by Casey Corner

Sincerely your Autistic child by AWNN

Uniquely human by Barry m prizant

Engaging autism by Stanley Greenspan

Raising human beings by Ross Greene

Beyond behaviours by Mona delahooke

The whole brain child by Dan Siegel & Tina Payne Bryson

Autism and gender by Jordynn Jack

It's your weirdness that makes you wonderful Kate Allan

Women and girls with autism spectrum disorder Sarah Hendrick

Worlds of Autism by Joyce davidson

Authoring autism by melanie yergeau

Nerdy Shy and Socially Inappropriate Cynthia Kim

Autistic disturbances by julie rodas

War on Autism by Annie McGuire

Rethinking autism diagnosis by kathenne Cole, Rebecca mallet, and sammy

Leaders all around me by Edlyn Vallejo Peña, PhD

Ido in autismland by Ido Kedar

Typed words loud voices by Amy Sequenzia & Elizabeth J. Grace

It's an autism thing by Emma Dalmayne

What Every Autistic Girl Wishes Her Parents Knew by Autism Women’s Network

Women on the Spectrum: A Handbook for Life by Emma Goodall and Yenn Purkis

Unmasking autism by Devon Price

Neurotribes by Steve Silberman

Love, Partnership or Singleton on the Autism Spectrum & Bittersweet on the Autism Spectrum, both edited by Luke Beardon and Dean Worton

Autism, Anxiety and Me: A Diary in Even Numbers by Emma Louise Bridge & Penelope Bridge

Autism: A New Introduction to Psychological Theory and Current Debate by Sue Fletcher-Watson and Francesca Happé

A Practical Guide to Happiness in Adults on the Autism Spectrum: A Positive Psychology Approach by Victoria Honeybourne

Gender Identity, Sexuality and Autism by Eva A. Mendes and Meredith R. Maroney

The Guide to Good Mental Health on the Autism Spectrum by Jeanette Purkis, Dr. Emma Goodall and Dr. Jane Nugent

Different, Not Less: A Neurodivergent's Guide to Embracing Your True Self and Finding Your Happily Ever After by Chloe Hayden

Memoirs:

Odd Girl Out by Laura James

Uncomfortable Labels by Laura Kate Dale

Drama Queen by Sara Gibbs

The Electricity of Every Living Thing by Katherine May

Fall down Seven Times Get Up Eight by Naoki Higashida

The Reason I Jump by Naomi Hashida

The Electricity of Every Living Thing by Katherine May

Wintering by Katherine May

Diary of a Young Naturalist by Dara McAnulty

Explaining Humans by Dr. Camilla Pang

Fingers in the Sparkle Jar by Chris Packham

Adult Fiction:

Adult Virgins Anonymous by Amber Crewe

Exciting Times by Naoise Dolan

A Girl Like Her by Talia Hibbert

Get a Life, Chloe Brown by Talia Hibbert

Act Your Age, Eve Brown by Talia Hibbert

Convenience Store Woman by Sayaka Murata

Failure to Communicate by Kaia Sønderby

An Unkindness of Ghosts by Rivers Solomon

[randomlyrandoms]

CELEBRITY DEATHS 2019

JANUARY Pegi Young - Jan. 1 (Folk Singer) Bob Einstein - Jan. 2 (TV Actor) Gene Okerlund - Jan. 2 (Sportscaster) Daryl Dragon - Jan. 2 (Pop Singer) Herb Kelleher - Jan. 3 (Entrepreneur) Jo Andres - Jan. 6 (Director) Annalise Braakensiek - Jan. 6 (TV Actress) Kevin Fret - Jan. 10 (Rapper) Mel Stottlemyre - Jan. 13 (Baseball Player) Carol Channing - Jan. 15 (Stage Actress) Hailie Masson - Jan. 17 (TikTok Star) Windsor Davies - Jan. 17 (TV Actor) Mary Oliver - Jan. 17 (Poet) Boo the Pomeranian - Jan. 18 (Dog) John Coughlin - Jan. 18 (Figure Skater) Sean Dolan - Jan. 19 (Family Member) *Ethan & Grayson's Father* Masazo Nonaka - Jan. 20 (Supercantenarian)   Emiliano Sala - Jan. 21 (Soccer Player) Ashley Lovelace - Jan. 21 (Imstagram Star) Kaye Ballard - Jan. 21 (Stage Actress) Russell Baker - Jan. 21 (Memoirist) Kevin Barnett - Jan. 22 (Comedian) James Frawley - Jan. 22 (Director) Oliver Mtukudzi - Jan. 23 (Reggae Singer) Aloysius Pang - Jan. 24 (TV Actor) Fatima Ali - Jan. 25 (Chef) Michel Legrand - Jan. 26 (Composer) Jayo Sama - Jan. 27 (Rapper) Pepe Smith - Jan 28 (Rock Singer) James Ingram - Jan. 29 (R&B Singer) Dick Miller - Jan. 30 (Movie Actor)

FEBRUARY Clive Swift - Feb. 1 (TV Actor) Neal James - Feb. 1 (Reality Star) *Kristoff St. John - Feb. 3 (Soap Opera Actor) Julie Adams - Feb. 3 (TV Actress) Matti Nykanen - Feb. 4 (Skier) Albert Finney - Feb. 7 (Movie Actor) John Dingell - Feb. 7 (Politician) Frank Robinson - Feb. 7 (Baseball Player) Fabio Legarda - Feb. 7 (Reggaeton Singer) Cadet - Feb. 9 (Rapper) Ron W. Miller - Feb. 9 (Entrepreneur) Jan Michael Vincent - Feb. 10 (Movie Actor) Pedro Morales - Feb. 12 (Wrestler) Gordon Banks - Feb. 12 (Soccer Player) Bruno Ganz - Feb. 15 (Movie Actor) Saban Saulic - Feb. 17 (Folk Singer) Sean Milliken - Feb. 17 (Reality Star) *Karl Lagerfeld - Feb. 19 (Fashion Designer) Stanley Donen - Feb. 21 (Director) Beverley Owen - Feb. 21 (TV Actress) Peter Tork - Feb. 21 (Pop Singer) Brody Stevens - Feb. 22 (Comedian) Morgan Woodward - Feb. 22 (TV Actor) Clark James Gable - Feb. 22 (TV Actor) Lisa Sheridan - Feb. 25 (TV Actress) Mark Hollis - Feb. 25 (Rock Singer) Christian Bach - Feb. 26 (Soap Opera Actress) Nathaniel Taylor - Feb. 27 (TV Actor) Andre Previn - Feb. 28 (Composer) Anna Cunningham - Feb. 28 (TikTok Star)

MARCH Katherine Helmond - March 1 (TV Actress) Elly Mayday - March 1 (Model) Janice Freeman - March 2 (Pop Singer) **Luke Perry - March 4 (TV Actress) Keith Flint - March 4 (Pop Singer) Ted Lindsay - March 4 (Hockey Player) King Kong Bundy - March 4 (Wrestler) Chokoleit - March 9 (Comedian) Jed Allan - March 9 (Soap Opera Actor) Hal Blaine - March 11 (Drummer) Felicite Tomlinson - March 13 (Instagram Star) Mike Thalassitis - March 15 (Reality Star) Lil Mister - March 15 (Rapper) Dick Dale - March 16 (Guitarist) Richard Erdman - March 16 (TV Actor) Scott Walker - March 22 (Pop Singer) Agnes Varda - March 29 (Director) Nipsey Hussle - March 31 (Rapper)

APRIL Wowaka - April 5 (Pop Singer) Seymour Cassel - April 7 (Movie Actor) Mya-Lecia Naylor - April 7 (TV Actress) Earl Thomas Conley - April 10 (Country Singer) Bibi Andersson - April 14 (Movie Actress) Georgia Engel - April 15 (TV Actress) Black Jezuss - April 15 (Rapper) Alan García - April 17 (Politician) Lorraine Warren - April 18 (Supernatural Investigator) Julio Melgar - April 19 (World Music Singer) Stefanie Sherk - April 20 (TV Actress) Ken Kercheval - April 21 (TV Actor) Mark Medoff - April 23 (Playwright) John Singleton - April 29 (Director) **Peter Mayhew - April 30 (Movie Actor)

MAY   Rachel Jones - May 4 (Blogger) Rachel Held Evans - May 4 (Religious Author) Max Azria - May 6 (Fashion Designer) Jim Fowler - May 8 (TV Show Host) Peggy Lipton - May 11 (TV Actress) Pua Magasiva - May 11 (TV Actor) Alvin Sargent - May 11 (ScreenWriter) Elsa Patton - May 12 (Reality Star) Doris Day - May 13 (Movie Actress) *Grumpy Cat - May 14 (Cat) Tim Conway - May 14 (TV Actor) Isaac Kappy - May 14 (Movie Actor) I.M. Pei - May 16 (Architect) Ashley Massaro - May 16 (Wrestler) Bob Hawke - May 16 (World Leader) Herman Wouk - May 18 (Noveist) Niki Lauda - May 20 (Race Car Driver) Bart Starr - May 26 (Football Player) Gabriel Diniz - May 27 (World Music Singer) Bill Buckner - May 27 (Baseball Player) Susan Anne Christman - May 29 (Family Member) Leon Redbone - May 30 (Jazz Singer) Patricia Bath - May 30 (Inventor) Roky Erickson - May 31 (Rock Singer)

JUNE José Antonio Reyes - June 1 (Soccer Player) Ani Yudhoyono - June 1 (Political Wife) Dr. John - June 6 (Jazz Singer) Noemi Ban - June 7 (Non-Fiction Author) Curlyhead.kidd - June 8 (Instagram Star) Mary Duggar - June 9 (Reality Star) Bushwick Bill - June 9 (Rapper) Gabriele Grunewald - June 11 (Runner) Sylvia Miles - June 12 (Movie Actress) Sean McCann - June 13 (TV Actor) Edith González - June 13 (Soap Opera Actress) Franco Zeffirelli - June 15 (Director) Bishop Bullwinkle - June 16 (Soul Singer) Mohamed Morsi - June 17 (Politician) Gloria Vanderbilt - June 17 (Entrepreneur) Philippe Zdar - June 19 (DJ) Judith Krantz - June 22 (Novelist) Dave Bartholomew - June 23 (Songwriter) Stephanie Niznik - June 23 (TV Actress) Fame Reek - June 24 (Rapper) Billy Drago - June 24 (Moive Actor) Etika - June 25 (Youtube Star) **Beth Chapman - June 26 (Reality Star) Max Wright - June 26 (TV Actor) Hella Sketchy - June 27 (Rapper)

JULY Tyler Skaggs - July 1 (Baseball Player) Lee Iacocca - July 2 (Entrepreneur) Arte Johnson - July 3 (TV Actor) Chris Cline - July 4 (Entrepreneur) **Cameron Boyce - July 6 (TV Actor) Martin Charnin - July 6 (Director) Joao Gilberto - July 6 (Guitarist) *Rip Torn - July 9 (Movie Actor) Freddie Jones - July 9 (Movie Actor) **Denise Nickerson - July 10 (Movie Actress) Emily Hartridge - July 12 (Youtube Star) Bianca Devins - July 14 (Instagram Star) Rutger Hauer - July 19 (Movie Actor) Gabe Khouth - July 23 (Voice Actor) David Hedison - July 23 (TV Actor) Beji Essebsi - July 25 (Politician) Russi Taylor - July 26 (Voice Actress) Carlos Cruz-Diez - July 27 (Pop Artist) Dillon Henderson - July 28 (Youtube Star) The King of Random - July 29 (Youtube Star) Nick Buoniconti - July 30 (Football Player) Harold Prince - July 31 (TV Producer)

AUGUST Toni Morrison - Aug. 5 (Novelist) David Berman - Aug. 7 (Rock Singer) Ben Unwin - Aug. 14 (TV Actor) Peter Fonda - Aug. 16 (Movie Actor) Cedric Benson - Aug. 17 (Football Player) Gina Lopez - Aug. 19 (Environmentalist) Jessi Combs - Aug. 27 (TV Show Host) Valerie Harper - Aug. 30 (TV Actress)

SEPTEMBER Peter Lindbergh - Sept. 3 (Photographer) Carol Lynley - Sept. 3 (Movie Actress) Lashawn Daniels - Sept. 3 (Songwriter) Chris March - Sept. 5 (Fashion Designer) Jimmy Johnson - Sept. 5 (Guitarist) Robert Mugabe - Sept. 6 (World Leader) Robert Axelrod - Sept. 7 (Voice Actor) Camilo Sesto - Sept. 8 (World Music Singer) Robert Frank - Sept. 9 (Photographer) Daniel Johnston - Sept. 11 (Folk Singer) Eddie Money - Sept. 13 (Rock Singer) Ric Ocasek - Sept. 15 (Rock Singer) Phyllis Newman - Sept. 15 (Stage Actress) Suzanne Whang - Sept. 17 (TV Actress) Cokie Roberts - Sept. 17 (Journalist) Aron Eisenberg - Sept. 21 (TV Actor) Sid Haig - Sept. 21 (Movie Actor) Carl Ruiz - Sept. 21 (Chef) Robert Hunter - Sept. 23 (Songwriter) Linda Porter - Sept. 25 (TV Actor) Jacques Chirac - Sept. 26 (Politician) Jose Jose - Sept. 28 (World Music Singer) Jessye Norman - Sept. 30 (Opera Singer) Louie Rankin - Sept. 30 (Reggae Singer)

OCTOBER Karel Gott - Oct. 1 (Pop Singer) Kim Shattuck - Oct. (Rock Singer) Diahann Carroll - Oct. 4 (TV Actress) Ginger Baker - Oct. 6 (Drummer) Rip Taylor - Oct. 6 (Movie Actor) Larry Junstrom - Oct. 6 (Guitarist) David Weisman - Oct. 9 (Film Producer) *Robert Forster - Oct. 11 (Movie Actor) Kadri Gopalnath - Oct. 11 (Saxophonist) Sulli - Oct. 14 (TV Actress) Elijah Cummings - Oct. 17 (Politician) Alicia Alonso - Oct. 17 (Dancer) Bill Macy - Oct. 17 (TV Actor) Willie Brown - Oct. 22 (Football Player) Robert Evans - Oct. 26 (Film Producer) John Witherspoon - Oct. 29 (TV Actor)

NOVEMBER Rudy Boesch - Nov. 1 (Reality Star) Brian Tarantina - Nov. 2 (TV Actor) Walter Mercado - Nov. 2 (TV Show Host) Laurel Griggs - Nov. 5 (Stage Actress) Fred Cox - Nov. 20 (Football Player) Goo Hara - Nov. 24 (Pop Singer) Gary Rhodes - Nov. 26 (Chef) Godfrey Gao - Nov. 27 (Model)

DECEMBER Shelley Morrison - Dec. 1 (TV Actress) Ron Leibman - Dec. 6 (TV Actor) Juice WRLD - Dec. 8 (Rapper) Caroll Spinney - Dec. 8 (Puppeteer) Rene Auberjonois - Dec. 8 (TV Actor) Marie Fredriksson - Dec. 9 (Pop Singer) Philip McKeon - Dec. 10 (TV Actor) Danny Aiello - Dec. 12 (Movie Actor) Chuy Bravo - Dec. 14 (Reality Star) Mama Cax - Dec. 16 (Blogger) Claudine Auger - Dec. 18 (Movie Actress) Sue Lyon - Dec. 26 (Movie Actress) Don Imus - Dec. 27 (Radio Host)

[the-walking-dead-collection]

(L-R) Rick Grimes (Andrew Lincoln), Lori Grimes (Sarah Wayne Callies), Carl Grimes (Chandler Riggs), Sophia Peletier (Madison Lintz), Carol Peletier (Melissa McBride), Theodore "T-Dog" Douglas (IronE Singleton), Glenn Rhee (Steven Yeun), Andrea (Laurie Holden), Dale Horvath (Jeffrey DeMunn), Daryl Dixon (Norman Reedus) e Shane Walsh (Jon Bernthal) - The Walking Dead 2ª Temporada - Foto: Matthew Welch/AMC

[neurogenpapers]

Novel genetic loci associated with hippocampal volume.

PubMed: Novel genetic loci associated with hippocampal volume. Nat Commun. 2017 Jan 18;8:13624 Authors: Hibar DP, Adams HH, Jahanshad N, Chauhan G, Stein JL, Hofer E, Renteria ME, Bis JC, Arias-Vasquez A, Ikram MK, Desrivières S, Vernooij MW, Abramovic L, Alhusaini S, Amin N, Andersson M, Arfanakis K, Aribisala BS, Armstrong NJ, Athanasiu L, Axelsson T, Beecham AH, Beiser A, Bernard M, Blanton SH, Bohlken MM, Boks MP, Bralten J, Brickman AM, Carmichael O, Chakravarty MM, Chen Q, Ching CR, Chouraki V, Cuellar-Partida G, Crivello F, Den Braber A, Doan NT, Ehrlich S, Giddaluru S, Goldman AL, Gottesman RF, Grimm O, Griswold ME, Guadalupe T, Gutman BA, Hass J, Haukvik UK, Hoehn D, Holmes AJ, Hoogman M, Janowitz D, Jia T, Jørgensen KN, Karbalai N, Kasperaviciute D, Kim S, Klein M, Kraemer B, Lee PH, Liewald DC, Lopez LM, Luciano M, Macare C, Marquand AF, Matarin M, Mather KA, Mattheisen M, McKay DR, Milaneschi Y, Muñoz Maniega S, Nho K, Nugent AC, Nyquist P, Loohuis LM, Oosterlaan J, Papmeyer M, Pirpamer L, Pütz B, Ramasamy A, Richards JS, Risacher SL, Roiz-Santiañez R, Rommelse N, Ropele S, Rose EJ, Royle NA, Rundek T, Sämann PG, Saremi A, Satizabal CL, Schmaal L, Schork AJ, Shen L, Shin J, Shumskaya E, Smith AV, Sprooten E, Strike LT, Teumer A, Tordesillas-Gutierrez D, Toro R, Trabzuni D, Trompet S, Vaidya D, Van der Grond J, Van der Lee SJ, Van der Meer D, Van Donkelaar MM, Van Eijk KR, Van Erp TG, Van Rooij D, Walton E, Westlye LT, Whelan CD, Windham BG, Winkler AM, Wittfeld K, Woldehawariat G, Wolf C, Wolfers T, Yanek LR, Yang J, Zijdenbos A, Zwiers MP, Agartz I, Almasy L, Ames D, Amouyel P, Andreassen OA, Arepalli S, Assareh AA, Barral S, Bastin ME, Becker DM, Becker JT, Bennett DA, Blangero J, van Bokhoven H, Boomsma DI, Brodaty H, Brouwer RM, Brunner HG, Buckner RL, Buitelaar JK, Bulayeva KB, Cahn W, Calhoun VD, Cannon DM, Cavalleri GL, Cheng CY, Cichon S, Cookson MR, Corvin A, Crespo-Facorro B, Curran JE, Czisch M, Dale AM, Davies GE, De Craen AJ, De Geus EJ, De Jager PL, De Zubicaray GI, Deary IJ, Debette S, DeCarli C, Delanty N, Depondt C, DeStefano A, Dillman A, Djurovic S, Donohoe G, Drevets WC, Duggirala R, Dyer TD, Enzinger C, Erk S, Espeseth T, Fedko IO, Fernández G, Ferrucci L, Fisher SE, Fleischman DA, Ford I, Fornage M, Foroud TM, Fox PT, Francks C, Fukunaga M, Gibbs JR, Glahn DC, Gollub RL, Göring HH, Green RC, Gruber O, Gudnason V, Guelfi S, Håberg AK, Hansell NK, Hardy J, Hartman CA, Hashimoto R, Hegenscheid K, Heinz A, Le Hellard S, Hernandez DG, Heslenfeld DJ, Ho BC, Hoekstra PJ, Hoffmann W, Hofman A, Holsboer F, Homuth G, Hosten N, Hottenga JJ, Huentelman M, Pol HE, Ikeda M, Jack CR, Jenkinson M, Johnson R, Jönsson EG, Jukema JW, Kahn RS, Kanai R, Kloszewska I, Knopman DS, Kochunov P, Kwok JB, Lawrie SM, Lemaître H, Liu X, Longo DL, Lopez OL, Lovestone S, Martinez O, Martinot JL, Mattay VS, McDonald C, McIntosh AM, McMahon FJ, McMahon KL, Mecocci P, Melle I, Meyer-Lindenberg A, Mohnke S, Montgomery GW, Morris DW, Mosley TH, Mühleisen TW, Müller-Myhsok B, Nalls MA, Nauck M, Nichols TE, Niessen WJ, Nöthen MM, Nyberg L, Ohi K, Olvera RL, Ophoff RA, Pandolfo M, Paus T, Pausova Z, Penninx BW, Pike GB, Potkin SG, Psaty BM, Reppermund S, Rietschel M, Roffman JL, Romanczuk-Seiferth N, Rotter JI, Ryten M, Sacco RL, Sachdev PS, Saykin AJ, Schmidt R, Schmidt H, Schofield PR, Sigursson S, Simmons A, Singleton A, Sisodiya SM, Smith C, Smoller JW, Soininen H, Steen VM, Stott DJ, Sussmann JE, Thalamuthu A, Toga AW, Traynor BJ, Troncoso J, Tsolaki M, Tzourio C, Uitterlinden AG, Hernández MC, Van der Brug M, van der Lugt A, van der Wee NJ, Van Haren NE, van 't Ent D, Van Tol MJ, Vardarajan BN, Vellas B, Veltman DJ, Völzke H, Walter H, Wardlaw JM, Wassink TH, Weale ME, Weinberger DR, Weiner MW, Wen W, Westman E, White T, Wong TY, Wright CB, Zielke RH, Zonderman AB, Martin NG, Van Duijn CM, Wright MJ, Longstreth WT, Schumann G, Grabe HJ, Franke B, Launer LJ, Medland SE, Seshadri S, Thompson PM, Ikram MA Abstract The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg=-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness. PMID: 28098162 [PubMed - in process] http://dlvr.it/N87Gjx

[the-walking-dead-collection]

(L-R) Shane Walsh (Jon Bernthal), Dale (Jeffrey DeMunn), Lori Grimes (Sarah Wayne Callies), Rick Grimes (Andrew Lincoln), T-Dog (Robert 'IronE' Singleton), Carl Grimes (Chandler Riggs), Andrea (Laurie Holden), Glenn (Steven Yeun), Sophia (Madison Lintz), Daryl Dixon (Norman Reedus), Carol (Melissa Suzanne McBride), Jacqui (Jeryl Prescott) e o Dr. Edwin Jenner (Noah Emmerich)

[neurogenpapers]

Novel genetic loci associated with hippocampal volume.

IoN UCL PubMed: Novel genetic loci associated with hippocampal volume. Nat Commun. 2017 Jan 18;8:13624 Authors: Hibar DP, Adams HH, Jahanshad N, Chauhan G, Stein JL, Hofer E, Renteria ME, Bis JC, Arias-Vasquez A, Ikram MK, Desrivières S, Vernooij MW, Abramovic L, Alhusaini S, Amin N, Andersson M, Arfanakis K, Aribisala BS, Armstrong NJ, Athanasiu L, Axelsson T, Beecham AH, Beiser A, Bernard M, Blanton SH, Bohlken MM, Boks MP, Bralten J, Brickman AM, Carmichael O, Chakravarty MM, Chen Q, Ching CR, Chouraki V, Cuellar-Partida G, Crivello F, Den Braber A, Doan NT, Ehrlich S, Giddaluru S, Goldman AL, Gottesman RF, Grimm O, Griswold ME, Guadalupe T, Gutman BA, Hass J, Haukvik UK, Hoehn D, Holmes AJ, Hoogman M, Janowitz D, Jia T, Jørgensen KN, Karbalai N, Kasperaviciute D, Kim S, Klein M, Kraemer B, Lee PH, Liewald DC, Lopez LM, Luciano M, Macare C, Marquand AF, Matarin M, Mather KA, Mattheisen M, McKay DR, Milaneschi Y, Muñoz Maniega S, Nho K, Nugent AC, Nyquist P, Loohuis LM, Oosterlaan J, Papmeyer M, Pirpamer L, Pütz B, Ramasamy A, Richards JS, Risacher SL, Roiz-Santiañez R, Rommelse N, Ropele S, Rose EJ, Royle NA, Rundek T, Sämann PG, Saremi A, Satizabal CL, Schmaal L, Schork AJ, Shen L, Shin J, Shumskaya E, Smith AV, Sprooten E, Strike LT, Teumer A, Tordesillas-Gutierrez D, Toro R, Trabzuni D, Trompet S, Vaidya D, Van der Grond J, Van der Lee SJ, Van der Meer D, Van Donkelaar MM, Van Eijk KR, Van Erp TG, Van Rooij D, Walton E, Westlye LT, Whelan CD, Windham BG, Winkler AM, Wittfeld K, Woldehawariat G, Wolf C, Wolfers T, Yanek LR, Yang J, Zijdenbos A, Zwiers MP, Agartz I, Almasy L, Ames D, Amouyel P, Andreassen OA, Arepalli S, Assareh AA, Barral S, Bastin ME, Becker DM, Becker JT, Bennett DA, Blangero J, van Bokhoven H, Boomsma DI, Brodaty H, Brouwer RM, Brunner HG, Buckner RL, Buitelaar JK, Bulayeva KB, Cahn W, Calhoun VD, Cannon DM, Cavalleri GL, Cheng CY, Cichon S, Cookson MR, Corvin A, Crespo-Facorro B, Curran JE, Czisch M, Dale AM, Davies GE, De Craen AJ, De Geus EJ, De Jager PL, De Zubicaray GI, Deary IJ, Debette S, DeCarli C, Delanty N, Depondt C, DeStefano A, Dillman A, Djurovic S, Donohoe G, Drevets WC, Duggirala R, Dyer TD, Enzinger C, Erk S, Espeseth T, Fedko IO, Fernández G, Ferrucci L, Fisher SE, Fleischman DA, Ford I, Fornage M, Foroud TM, Fox PT, Francks C, Fukunaga M, Gibbs JR, Glahn DC, Gollub RL, Göring HH, Green RC, Gruber O, Gudnason V, Guelfi S, Håberg AK, Hansell NK, Hardy J, Hartman CA, Hashimoto R, Hegenscheid K, Heinz A, Le Hellard S, Hernandez DG, Heslenfeld DJ, Ho BC, Hoekstra PJ, Hoffmann W, Hofman A, Holsboer F, Homuth G, Hosten N, Hottenga JJ, Huentelman M, Pol HE, Ikeda M, Jack CR, Jenkinson M, Johnson R, Jönsson EG, Jukema JW, Kahn RS, Kanai R, Kloszewska I, Knopman DS, Kochunov P, Kwok JB, Lawrie SM, Lemaître H, Liu X, Longo DL, Lopez OL, Lovestone S, Martinez O, Martinot JL, Mattay VS, McDonald C, McIntosh AM, McMahon FJ, McMahon KL, Mecocci P, Melle I, Meyer-Lindenberg A, Mohnke S, Montgomery GW, Morris DW, Mosley TH, Mühleisen TW, Müller-Myhsok B, Nalls MA, Nauck M, Nichols TE, Niessen WJ, Nöthen MM, Nyberg L, Ohi K, Olvera RL, Ophoff RA, Pandolfo M, Paus T, Pausova Z, Penninx BW, Pike GB, Potkin SG, Psaty BM, Reppermund S, Rietschel M, Roffman JL, Romanczuk-Seiferth N, Rotter JI, Ryten M, Sacco RL, Sachdev PS, Saykin AJ, Schmidt R, Schmidt H, Schofield PR, Sigursson S, Simmons A, Singleton A, Sisodiya SM, Smith C, Smoller JW, Soininen H, Steen VM, Stott DJ, Sussmann JE, Thalamuthu A, Toga AW, Traynor BJ, Troncoso J, Tsolaki M, Tzourio C, Uitterlinden AG, Hernández MC, Van der Brug M, van der Lugt A, van der Wee NJ, Van Haren NE, van 't Ent D, Van Tol MJ, Vardarajan BN, Vellas B, Veltman DJ, Völzke H, Walter H, Wardlaw JM, Wassink TH, Weale ME, Weinberger DR, Weiner MW, Wen W, Westman E, White T, Wong TY, Wright CB, Zielke RH, Zonderman AB, Martin NG, Van Duijn CM, Wright MJ, Longstreth WT, Schumann G, Grabe HJ, Franke B, Launer LJ, Medland SE, Seshadri S, Thompson PM, Ikram MA Abstract The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg=-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness. PMID: 28098162 [PubMed - in process] http://dlvr.it/N86C1H