#Metabolic function

[aunhinged]

Johnlock concept: Sherlock gets tipsy/drunk 02

Sherlock's first experience of drunkenness in front of John would be nothing short of the social experiment of the year.

It starts out innocently enough, Sherlock dismissing alcohol as a "pointless social lubricant". Insisting it won't affect him because his "metabolism is far too advanced." A few glasses of wine later, he's half-draped over the armchair, lecturing John on the "intellectual merits of bees."

Sherlock: John, do you ever stop and think about bees? The perfect little systems they have. Communal, focused, productive. Unlike humans. Unlike me... mostly you, though.

At some point, John realizes Sherlock’s actually slurring, but Sherlock refuses to admit it.

Sherlock: I’m not drunk, John. I’m..re-evaluating my diction. You should try it, ‘diction,’ fascinating word... dic-tion.

He stumbles on his own feet mid-sentence.

Sherlock attempts to analyze John’s facial expressions

Sherlock: You’re frowning, and that means you’re... either tired, or hungry, or... worried I’m about to fall again. Unnecessary concern, John. My balance is fine.

Seconds later, Sherlock nearly knocks over a lamp.

John’s trying to get him to stop talking about everything and nothing at once, but Sherlock is now recounting every minor injustice from their cases in the past year. Including Lestrade "insulting his coat" and how Molly once “offered him average coffee.”

Mid-rant, Sherlock suddenly pauses, swaying slightly, and looks at John.

Sherlock: You know, John... I used to think I could do this whole detective thing on my own. But that was before you. I mean, I was great before you. But now... I’m...exce..exceptional.”

Johns trying not to choke on his tea with that one

Eventually, Sherlock begins confessing that John has a very "soothing aura."

Sherlock: John, you’re like... a very calm... tree. Tall, steady, good to lean on.

John, smirking: A tree, Sherlock?

Sherlock, dead serious: Yes. Quite.

Round 1 am, Sherlock begins a grand speech about the failures of the British government, which somehow ends in a tearful realization that he really likes John’s jumpers.

Sherlock: John, you don’t understand, I envy your knitwear. It’s so... reliable. Like you.

By the end of the night, John gets Sherlock into bed, but not before Sherlock decides to muse about how “annoyingly decent” John is.

Sherlock: You’re... you’re a very difficult man to ignore, John Watson. Always here, always... there. What’s it like, to be so... solid?

John just sighs, pats Sherlock on the head, and says, Go to sleep, you git.

The next morning, Sherlock wakes up and absolutely denies everything.

Sherlock: I did not discuss the intricacies of your knitwear, John. You must be mistaken.

John: Sherlock, you called me a tree.

Sherlock, frowning: I would never compare you to vegetation. That’s preposterous

[sanguinesorcery]

i said i was going to try to write today

i did not say where i was going to write...

[femmesday-addams]

oh no! by marina became a trinity and mel song for me at approximately 9:23a.m. in case anyone else would like worms in their brains and also ears

[er-cryptid]

Precapillary Sphincter

Patreon

[crimsonender]

I'm glad you mention people with metabolic disorders like, as a fat guy with a metabolic disorder it's really frustrating seeing how people dismiss that as a factor in weight gain and maintenance, including doctors :/ like the number of professionals I have been to in my life- let alone regular old ignorant assholes I encounter- who think telling me to eat healthy and exercise more is going to unlock the secret skinny person that they've miraculously discovered hidden inside a lazy fatty... like you of all people should know my thyroid numbers buddy

I also think that like, something got twisted here. If you're fat you shouldn't give up on your body. You should still eat healthy. Even if eating a perfectly healthy and functional diet doesn't lose you a single pound, you should still do it and it's really important to drive that home to people that are overweight because they are at a higher risk of depression and developing eating disorders, many of which can include binge and binge/restrict type disorders. Because fat people also have a harder time moving around, its just easier for fat people not to. But again, you should build up muscle strength and be able to move around comfortably regardless of how much you weigh.

Being fat doesn't mean, necessarily, that your body is swimming in glucose and carbs and salt, but fat people that don't see themselves ever getting "better" might allow for that to happen because of how much they hate the way they look. Thats why "healthy at any size" is an important movement. Its not about saying "yep. Any size is healthy no matter what!" its that you should try to to be healthy no matter what the scale says. Thats *always* a good thing and *always* better for you.

As a personal anecdote there was a time of my life that I had stopped exercising and didn't give a SHIT what I was putting in my body. I had developed a very bad walking gait that was actively injuring my joints. My core muscles were so weak I couldn't sit up in a chair for longer than twenty minutes without the base of my spine throbbing in level 10 stabbing pain that was so bad it made me dizzy. My gut health was awful and every trip to the toilet was miserable and exhausting.

Then, I started eating right. Then I started exercising. I opted to sit at my desk instead of lounging in bed or on my couch, in an upright chair to start building my core up again. I went on walks. I got a physio consultation and found out that I literally had to relearn how to walk, and even now have to make sure I'm not rocking side to side on my ankles and grinding the joint into the socket with each step, every time I go walking. I have not stepped on a scale in four years. I'm honestly not sure if I am comfortable doing that. I don't know how much weight I lost, but I know it's not nothing because pants that were tight on me three years ago now fall off my ass if I don't cinch them with a belt. (That i had to cut new notches into, because when i bought it I could barely buckle it up around my middle, but now the smallest notch was still too loose.)

I'm not really thinking about my size, I'm not thinking about the number. I'm thinking about how good it feels to feel nourished. How much I can appreciate the sweetness of young vegetables because I rarely eat things like snack cakes anymore. I can go on a six hour hike and my legs feel fine. (even if Im a little slow.) I am more in tune with my body and I don't eat until my stomach hurts, feel guilty, and then punish myself for the rest of the week by not eating anything... only to inhale everything in the cupboard at 2am because of how much I've starved myself. Going to the toilet isn't painful and miserable anymore. I am still fat. I probably always will be, thats the phenotype I've been given. But I just am happier, more comfortable, and more capable since I started giving a shit about my body regardless of what size and shape it is.

All that to say that distorting this and the ideas that go into this sort of positive, healthy mindset into "if you just eat better and work out you'll be skinny" no the fuck you won't. the healthy skinny svelte version of me you're making up in your head doesn't exist, even at my peak, even at my most healthy, I'm gonna be chunky and stout and I'm fine with that. And if you're my Doctor, you better get fine with it too.

[hakuryuu]

whyd i inherit my mom's Dental Experiences Curse

[the-punforgiven]

Dungeon Meshi has ruined my fucking brain dude

[chicago-geniza]

Great news. It is 70 degrees out realfeel in the 80s with no cloud cover so I went to the Korean grocery store then got home, vomited about a pint of bile, and briefly passed out. POTS will kill me via climate change AMA

[kiddokori]

ive seen the idea that link’s power of the triforce manifests itself in the fact that hes able to tank hits that would kill any normal person and then get up again no problem i have Not seen anyone point out that this could coincide with his love to eat and sleep. when normal people just lightly work out it shoots up how much they need to eat to fuel all that effort imagine youre running for days straight no pitstops and also fighting dragons and also almost dying every day this guy has to carbo load like crazy to keep up with all the shit he does. and then to get out of it mostly unscathed your body needs rest when it’s hurt and also just like in general no wonder he immediately passes the fuck out whenever he sits still for more than two seconds. he’s like a giant furnace you gotta just constantly shovel coal into aka he eats as much as 10 people in one sitting and then conks out for 48 hours

[blueoaknx]

Reclaim Vitality: The Science Behind Mitochondrial Biogenesis

Mitochondrial biogenesis is the cellular process of increasing the number of mitochondria, the organelles responsible for generating energy. This process is essential for maintaining cellular health and vitality, particularly in tissues with high energy demands, such as muscles. Mitochondrial biogenesis is often triggered by increased energy demand, usually resulting from exercise, caloric restriction, or the intake of specific nutrients.

Mitochondria are the energy producers of the cell, generating ATP, the energy currency of the cell, through oxidative phosphorylation. As cells face greater energy demands, they need more mitochondria to meet these requirements efficiently. The increase in mitochondrial numbers allows cells to produce more energy and better adapt to stress, thus enhancing overall health, recovery, and performance.

Key Factors Involved in Mitochondrial Biogenesis

Several molecular regulators drive mitochondrial biogenesis, with the most important being:

PGC-1α ActivationPGC-1α (Peroxisome proliferator-activated receptor gamma coactivator 1-alpha) is recognized as the master regulator of mitochondrial biogenesis. This protein plays a pivotal role in controlling the transcription of nuclear genes that encode mitochondrial proteins. When activated by external stimuli like exercise, PGC-1α interacts with transcription factors like NRF-1 and NRF-2 to drive the production of new mitochondria. This results in increased mitochondrial DNA (mtDNA) replication and the synthesis of mitochondrial proteins necessary for energy production and cellular respiration.

AMPK & SirtuinsAMPK (AMP-activated protein kinase) is another critical regulator that responds to low energy levels within the cell (a high AMP ratio). It activates PGC-1α, which, in turn, increases the number of mitochondria. AMPK is activated during energy-demanding activities such as endurance exercise and fasting. Sirtuins (SIRT1) are a class of NAD+-dependent enzymes that also regulate mitochondrial biogenesis. Sirtuins, especially SIRT1, deacetylate PGC-1α, further activating it to promote the transcription of mitochondrial genes. Both AMPK and sirtuins respond to energy deprivation, whether through physical exertion or caloric restriction, helping cells increase energy efficiency and prolong cellular longevity.

Antioxidant Defense and Cellular ResilienceOne of the benefits of mitochondrial biogenesis is the enhancement of cellular resilience through improved antioxidant defences. Mitochondria are not only energy producers but also sources of reactive oxygen species (ROS), which can damage cells if not adequately managed. By increasing the number of healthy mitochondria, cells improve their ability to manage oxidative stress. New mitochondria are typically more efficient at energy production and less likely to produce excess ROS, reducing overall cellular damage. This process helps to protect cells from age-related decline and stress-induced damage.

How Mitochondrial Biogenesis Impacts Health and Performance

Mitochondrial biogenesis is essential for maintaining optimal energy production, particularly during periods of increased physical activity or stress. In muscle cells, the increased number of mitochondria leads to improved ATP generation, enhancing endurance and reducing fatigue during prolonged exercise. This is particularly important for athletes or individuals who engage in regular physical activity, as their muscles require a constant supply of energy for performance and recovery.

For general health, mitochondrial biogenesis supports metabolic efficiency and longevity. In metabolic disorders like type 2 diabetes and obesity, mitochondrial dysfunction often results in impaired energy metabolism and increased oxidative stress. By promoting mitochondrial biogenesis, cells can restore normal mitochondrial function, improving insulin sensitivity and energy balance. Furthermore, mitochondrial biogenesis may help reduce the risk of chronic diseases related to ageing by maintaining cellular energy production and reducing oxidative stress.

Beyond exercise and metabolic health, mitochondrial biogenesis is also a key factor in the body’s ability to adapt to various stressors, whether environmental or nutritional. The increase in mitochondrial capacity allows cells to better handle changes in energy demand, supporting recovery and cellular adaptation. For instance, during periods of caloric restriction, mitochondrial biogenesis helps the body use energy more efficiently, contributing to longer-term health benefits, including improved longevity and resistance to age-related diseases.

Supporting Mitochondrial Biogenesis with Nutraceuticals

In addition to lifestyle factors like exercise and caloric restriction, certain nutraceuticals can support mitochondrial biogenesis. Mitokatlyst™-E is one such product that targets mitochondrial function, optimising energy production, and promoting muscle recovery. By stimulating the molecular pathways involved in mitochondrial biogenesis, such products can enhance the body’s ability to adapt to stress, recover more efficiently, and improve overall cellular function.

Conclusion

Mitochondrial biogenesis is a vital process that supports energy production, cellular health, and adaptability to environmental and physical stressors. By regulating pathways such as PGC-1α, AMPK, and sirtuins, cells can increase mitochondrial content to meet higher energy demands, promote muscle recovery, and improve overall vitality. Products like Mitokatlyst™-E are designed to optimise mitochondrial function, helping the body adapt to stress and maintain optimal cellular health. By supporting mitochondrial biogenesis, we can improve energy efficiency, enhance physical performance, and promote long-term health and resilience.

[dykethang]

hm i think taking the antipsychotics at night is good because then i don't sleep during the day but also i metabolize meds in such a jacked up way that it's not as effective if i take it at night

[er-cryptid]

Tonic vs Phasic Smooth Muscle

Tonic Smooth Muscle -- always partially contracted -- relatively low resting potential

Phasic Smooth Muscle -- contracts in bursts -- triggered by action potentials

Patreon

[falseandrealultravival]

The house that gives birth to metabolic syndrome (verse)

metabolic syndrome

in a TV commercial

I saw the PanaHome broadcast

In the explanation, the line of flow (the path that moves in the work)

People who do housework because they are organized

It is said that the distance to move is reduced

About 140km per year.

I see, this is easy!

However - as long as it doesn't move

The body's calorie-burning function does not work

It is stored in the body as excess energy.

This is not about metabolic syndrome!

It is a house that gives birth to metabolic syndrome.

Note :”PanaHome” is a housing maker in Japan.

(2018.04.20)

メタボを産む家

テレビコマーシャルで

パナホームの放送を見た

何でも動線（作業で動く経路）を

整理したので家事をやる人は

年間１４０ｋｍくらいは

動く距離が減るのだという。

なるほど、これは楽！

ただし――動かない分は

体のカロリー消費機能は働かず

過剰エネルギーとして体に蓄積される。

これってメタボのことじゃん！

メタボを産む家である。

[yuribait]

making up fake disease in my head instead of trying to develop my actual ocs more wheee

[bsahely]

Foundations of Coherence-Centered Medicine: A Rhythmic Framework for Restoring Systemic Health | ChatGPT4o

[Download Full Document (PDF)] Overview Foundations of Coherence-Centered Medicine presents a paradigm shift in clinical care, where the restoration of rhythmic and systemic coherence replaces the suppression of isolated symptoms. It asserts that chronic illness often reflects not biochemical failure but breakdowns in pattern, rhythm, and integration across biological and symbolic layers. Core…