#Nanotoxicity

[symbiosisonlinepublishing]

𝐇𝐞𝐚𝐥𝐭𝐡𝐜𝐚𝐫𝐞: Nanoparticles can be used to deliver drugs to specific parts of the body, to diagnose diseases, and to create new medical devices. 𝐄𝐧𝐞𝐫𝐠𝐲: Nanotechnology can be used to create new solar cells, batteries, and fuel cells. 𝐈𝐧𝐟𝐨𝐫𝐦𝐚𝐭𝐢𝐨𝐧 𝐭𝐞𝐜𝐡𝐧𝐨𝐥𝐨𝐠𝐲: Nanotechnology can be used to create new computer chips, sensors, and displays.

Visit: https://symbiosisonlinepublishing.com/nanoscience-technology/

[laocommunity]

Uncovering the Mystery: Scientists Unravel Novel Ancestral Defense Mechanism Against Nanoparticles

Uncovering the Mystery: Scientists Unravel Novel Ancestral Defense Mechanism Against Nanoparticles Uncovering the Mystery: Scientists Unravel Novel Ancestral Defense Mechanism Against Nanoparticles As researchers delve deeper into the world of nanotechnology, they have encountered a major hurdle - the challenge of nanoparticles and their toxicity in biological systems. However, recent studies have uncovered a revolutionary defense mechanism that has been in place since the beginning of evolution. The Challenge of Nanoparticles As the field of nanotechnology has rapidly grown, the production of nanoparticles has increased exponentially. These tiny particles, often less than 100 nanometres in size, have unique properties that make them highly desirable for use in various industrial and medical applications. However, their small size also makes them potentially dangerous when they come into contact with biological systems. Nanoparticles have been shown to be toxic to many organisms, including humans. This toxicity is due to the small size of the particles, which allows them to easily penetrate biological membranes and interact with proteins, DNA and other essential molecules. Unraveling the Defense Mechanism In a recent study, a team of scientists has discovered a novel defense mechanism that has been present in organisms since the beginning of evolution. The mechanism involves the production of proteins called "ancestral nanotoxic response proteins" or ANRPs. ANRPs have been found in a variety of organisms, including bacteria, fungi, plants and animals. These proteins are produced in response to the presence of nanoparticles, and they have a unique ability to interact with and neutralize the toxic effects of these particles. How ANRPs Work ANRPs work by binding to nanoparticles and forming a protective barrier around them. This protects the surrounding biological structures from the toxic effects of the particles. Additionally, ANRPs have been found to stimulate the immune system to attack and remove the particles from the body. The discovery of ANRPs is significant because it provides a natural defense mechanism against the toxicity of nanoparticles. This mechanism has been in place since the beginning of evolution and has been refined over millions of years of evolution. The Implications of ANRPs The discovery of ANRPs opens up a whole new avenue of research and development in the field of nanotechnology. By understanding how ANRPs work, scientists can develop new ways to produce nanoparticles that are less toxic to biological systems. Additionally, ANRPs could be used therapeutically to treat diseases caused by exposure to nanoparticles. Conclusion The discovery of ANRPs is a major breakthrough in the field of nanotechnology. It shows that nature has evolved to protect organisms from the toxicity of nanoparticles, and this defense mechanism can be harnessed to develop safer and more effective nanotechnologies. FAQs Q1. What are nanoparticles? A1. Nanoparticles are tiny particles that are less than 100 nanometres in size. Q2. Why are nanoparticles toxic? A2. Nanoparticles are toxic because their small size allows them to easily penetrate biological membranes and interact with essential molecules like proteins and DNA. Q3. What are ANRPs? A3. ANRPs are ancestral nanotoxic response proteins, which are produced in response to the presence of nanoparticles and have a unique ability to interact with and neutralize the toxic effects of these particles. Q4. How do ANRPs work? A4. ANRPs work by binding to nanoparticles and forming a protective barrier around them. This protects the surrounding biological structures from the toxic effects of the particles. Q5. What are the implications of ANRPs? A5. ANRPs could be used to develop safer and more effective nanotechnologies, as well as to treat diseases caused by exposure to nanoparticles. #TECH Read the full article

[openlylyingforclout]

The dye used to deepen the color on commercial oranges is nanotoxic, so it's actually super unsafe to zest oranges now. (The insides are still safe to eat)

[jogkin]

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Analytical Methodologies for Nanotoxicity Assessment - TutorsIndia

Description TutorsIndia alternatives to the use of Animal in vivo studies for Nanotoxicity Assessment using in Vitro and Silico Approach.

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[alkhemya]

@zimtec-archived-blog @primxmvivere-blog @raitobu @neovedi-blog @swordhanded-blog @hyugakito-blog @aabluviion-blog @aestus-volucer @postvoidedarchive-blog @coloratii-archive @gaarnit-blog @gemoftheheart-archive-blog @laheyy-blog @mabelkind-blog @zerosdraws @sxaerheth @firesmothered-archive-blog @datavoxs @nanotoxic @komyona-blog @ofbriar @omnitrixtic @retrounit @cosmicunit-blog @crownsless @laketoyas-blog @harunodesu-archive-blog-blog @colourless-redemption-blog @riskofhatred @aikokushinn @isobusrinchuriki-blog @crestfallenfang @ninetaileduzumaki-blog @freexom-blog @theoutcastuchiha @snack-o-lantern @xstonehard-archive @nakurhedo @medninarchive-blog @otobaibitch-blog @copycanine @lackstrength @lcsquee @akxsunaarchive @legacy-of-a-team @leafmutt @stiffshoulders @owaruu @sordidsensoryarchives @fuun-hime 

Ray-Ban Sunglasses

[krishnatwinkle-blog]

Drug delivery in nanotechnology and nanomedicine

Nanotechnology has given the likelihood of conveying medications to explicit cells utilizing nanoparticles. The general medication utilization and reactions might be brought down fundamentally by saving the dynamic operator in the dreary district just and in no higher portion than required. Directed medication conveyance is proposed to diminish the symptoms of medications with attendant declines in utilization and treatment costs. Medication conveyance centers around expanding bioavailability both at explicit places in the body and over some stretch of time. This can possibly be accomplished by atomic focusing by nanoengineered gadgets. An advantage of utilizing nanoscale for medicinal advancements is that littler gadgets are less intrusive and can be embedded inside the body, in addition to biochemical response times are a lot shorter. These gadgets are quicker and more delicate than ordinary medication conveyance. The viability of medication conveyance through nanomedicine is generally founded on an) effective exemplification of the medications, b) fruitful conveyance of medication to the focused on the locale of the body, and c) fruitful arrival of the drug.

Medication conveyance frameworks, lipid-or polymer-based nanoparticles, can be intended to improve the pharmacokinetics and biodistribution of the medication. Be that as it may, the pharmacokinetics and pharmacodynamics of nanomedicine are a very factor among various patients. At the point when intended to keep away from the body’s guard components, nanoparticles have gainful properties that can be utilized to improve sedate conveyance. Complex medication conveyance instruments are being created, including the capacity to get sedates through cell films and into the cell cytoplasm. The activated reaction is one route for medication atoms to be utilized all the more effective. Medications are set in the body and just actuate on experiencing a specific flag. For instance, a medication with poor solvency will be supplanted by a medication conveyance framework where both hydrophilic and hydrophobic conditions exist, improving the dissolvability. Medication conveyance frameworks may likewise have the capacity to anticipate tissue harm through managed sedate discharge; decrease tranquilize leeway rates, or lower the volume of appropriation and lessen the impact on non-target tissue. Notwithstanding, the biodistribution of these nanoparticles is as yet flawed because of the unpredictable host’s responses to nano-and microsized materials and the trouble in focusing on explicit organs in the body. All things considered, a great deal of work is as yet continuous to streamline and better comprehend the potential and restrictions of nanoparticulate frameworks. While the progression of research demonstrates that focusing on and appropriation can be expanded by nanoparticles, the perils of nanotoxicity turn into a critical subsequent stage in the further comprehension of their medicinal employment.

[brainwaredm1]

Win the fight against COVID-19

The search is on to find the perfect drug or vaccine to stop the spread of COVID-19. How can it be accomplished? The Department of Pharmaceutical Technology, Brainware University organised a webinar on “Protien Reliability Analysis and In Silico Modeling of Natural Inhibitors for SARS-CoV-2 Main Protease(Mpro): A Probable Solution for COVID-19” on 11 June 2020 to discuss the process of drug synthesis and diagnosis of this deadly infection. Our guest speaker Dr. Supratik Kar(Post Doctorate Research Associate, Interdisciplinary Center for Nanotoxicity, Jackson State University- MS,USA) discussed in details how computer aided drug designs, virtual screening, and other in-silico approaches are being used to find suitable drug testing candidates. Since we have at hand technology aided drug production is appreciably reducing production time and making it easier to look forward to a commercial COVID-19 drug. It will take some time yet but  advancements in pharmaceutical science have changed things for the better. Mr. Kar also advised students on the growing opportunities in the pharmaceutical field post-pandemic. It is expected that following the pandemic Government and corporate organisations will invest more in the health sector. That’s great news for the students who are looking to join the industry soon. The discussion ended with a Q &A session and was extremely useful for the students. We shall continue to provide such opportunities for our students to learn and grow.

[caglararli]

Nanotox https://www.instagram.com/p/Bql0Uy3Fxdm/?utm_source=ig_tumblr_share&igshid=1imbnqosivbbb

[leedsomics]

Role of omics techniques in the toxicity testing of nanoparticles.

Related Articles Role of omics techniques in the toxicity testing of nanoparticles. J Nanobiotechnology. 2017 Nov 21;15(1):84 Authors: Fröhlich E Abstract Nanotechnology is regarded as a key technology of the twenty-first century. Despite the many advantages of nanotechnology it is also known that engineered nanoparticles (NPs) may cause adverse health effects in humans. Reports on toxic effects of NPs relay mainly on conventional (phenotypic) testing but studies of changes in epigenome, transcriptome, proteome, and metabolome induced by NPs have also been performed. NPs most relevant for human exposure in consumer, health and food products are metal, metal oxide and carbon-based NPs. They were also studied quite frequently with omics technologies and an overview of the study results can serve to answer the question if screening for established targets of nanotoxicity (e.g. cell death, proliferation, oxidative stress, and inflammation) is sufficient or if omics techniques are needed to reveal new targets. Regulated pathways identified by omics techniques were confirmed by phenotypic assays performed in the same study and comparison of particle types and cells by the same group indicated a more cell/organ-specific than particle specific regulation pattern. Between different studies moderate overlap of the regulated pathways was observed and cell-specific regulation is less obvious. The lack of standardization in particle exposure, in omics technologies, difficulties to translate mechanistic data to phenotypes and comparison with human in vivo data currently limit the use of these technologies in the prediction of toxic effects by NPs. PMID: 29157261 [PubMed - indexed for MEDLINE] http://dlvr.it/QZmLS7

[jnanostruct-blog]

Nanotoxicity for E. Coli and Characteriz

Nanotoxicity for E. Coli and Characteriz

Nanotoxicity for E. Coli and Characterization of Silver Quantum Dots Produced by Biosynthesis with Eichhornia crassipes http://ow.ly/88E630fdqte #SilverNanoparticles #Biosynthesis #EichhorniaCrassipes #HydrolysableTannins #Cytotoxicity #EscherichiaColi

[environmentguru]

Responses of Periphyton to Fe2O3 Nanoparticles - a Physiological and Ecological Basis for Defending Nanotoxicity

Responses of Periphyton to Fe2O3 Nanoparticles - a Physiological and Ecological Basis for Defending Nanotoxicity https://www.environmentguru.com/pages/elements/element.aspx?utm_source=dlvr.it&utm_medium=tumblr&id=5367476

[fruit-worm-papers]

Toxicity-based toxicokinetic/toxicodynamic assessment of bioaccumulation and nanotoxicity of zerovalent iron nanoparticles in Caenorhabditis elegans.

http://dlvr.it/PX5SdK

[healthy-insights]

Polymerase Chain Reaction (PCR) Market: Technologies, Markets and Players

Polymerase chain reaction (PCR) enables DNA sequencing and helps in determining the order of its building blocks. PCR finds applications in disease diagnosis, forensic sciences, and identification of bacteria and viruses. PCR is an excellent technique for rapid detection of microbial contamination and pathogens, including those complicated to culture. These techniques are precise and robust methods that rely on polymerase enzyme to amplify trace amounts of DNA/RNA fragments by creating several identical or near-identical copies. The demand for greater efficiency and productivity in the pharmaceutical industry has led to the growth of this market.

Download The Full Brouchre of Report:

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The report on the global PCR Market studies the global PCR market in terms of products, end-users, applications and geography. Each of these segments has been analyzed in detail for market trends, recent developments, outlook and opportunities and various applications. The report provides the market size in terms of value (USD million) for each segment and sub-segment for the period from 2012 to 2020, considering the macro- and micro environmental factors. In addition, the compounded annual growth rate (CAGR) of the overall market and the segments has also been included in the report for the forecast period from 2014 to 2020, considering 2012 and 2013 as the base years. The PCR products studied in this report include instruments, and reagents and consumables. Instruments are further classified by type such as standard PCR, quantitative real time PCR (qPCR) and digital PCR (dPCR). Pharmaceutical and biotech industries, clinical diagnostic laboratories, hospitals, academics and public research organizations are the major end-users of the global PCR market. PCR Applications segment has been further categorized as clinical diagnostics, life sciences and others such as forensic sciences, agriculture and nanotoxicity studies. Geographically, the market has been segmented into four regions: North America, Europe, Asia Pacific and Rest of the World (RoW). The market size and forecast in terms of value (USD Million) for each of these regions along with the CAGR for the forecast period from 2014 to 2020 have been provided in the report. A detailed qualitative analysis of the major factors determining market dynamics such as drivers, restraints and opportunities, along with the market attractiveness analysis are discussed in the market overview section of the report. The study provides a list of recommendations for new companies willing to enter the market and for existing companies to increase market shares, which is likely to help in the decision-making process. Event impact analysis has also been provided in this report that will help in understanding the major events impacting the PCR market growth. The study is a robust combination of primary and secondary research. Primary research formed the bulk of our research efforts with information collected from telephonic interviews and interaction via e-mails. Secondary research involved study of company websites, annual reports, press releases, stock analysis presentations, and various international and national databases for patents, clinical trials, demographics, disease incidence/prevalence, etc. For estimating the market size in terms of value, revenue generation by the PCR instruments, and reagents and reaction consumables has been considered. Most of the leading players in the PCR market manufacture both consumables as well as instruments. The level of product differentiation plays a major role in determining the market position of these players. Several players are trying to enter and establish themselves in the PCR market, especially in emerging economies. Major players operating in this market are Affymetrix, Inc., Agilent Technologies, Inc., Sigma Aldrich Corporation, Abbott Laboratories, Beckman Coulter, Bio-Rad Laboratories, GE Healthcare, QIAGEN, Becton Dickinson & Company and Thermo Fischer Scientific. The global PCR market is segmented as follows:

Global PCR Market Revenue (USD Million), by Products

Instruments

Standard PCR Systems

Real Time PCR Systems

Digital PCR Systems

Reagents and Consumables

Global PCR Market Revenue (USD Million), by End-Users

Pharmaceutical and Biotechnology Industries

Clinical Diagnostics Labs and Hospitals

Academic and Research Organizations

Global PCR Market Revenue (USD Million), by Applications

Clinical Diagnostics

Life Sciences

Others

Global PCR Market Revenue (USD Million), by Geography

North America

Instruments

Reagents and Consumables

Europe

Instruments

Reagents and Consumables

Asia Pacific

Instruments

Reagents and Consumables

Rest of World

Instruments

Reagents and Consumables

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[udelaware]

Spicing up modern medicine

Lots of high-tech analysis goes into baseball strategy these days, but the crowds love the natural rhythms of the game - the crack of the bat, the dust cloud as a runner slides into base, the umpire’s strikeout gesture. Caitlin Blades, a McNair Scholar from Bridgeville, Del., is doing research that mixes new techniques and natural substances - using nanoparticles of the herb curcumin to fight inflammatory breast cancer cells. Some of the particles are coated in a specific polymer, some are not. “The ability to intertwine modern medicine techniques with natural herbs such as curcumin, which has been a health remedy for centuries, honestly blows my mind,” she said.

The research could lead to ideal new ways to deliver chemotherapy and Caitlin would like to create a system to examine the efficiency of the coated nanoparticles in the bloodstream.

When she is not strategizing against lethal cancers, she travels as much as possible to develop her Spanish language skills and experience other cultures. “I love adventure and the feeling of the wind blowing on my face, so I go mountain rappelling, rollerblading, crabbing and fishing as often as I can. I use my creative side to write poetry and my hands to design and sell my own clothing. Additionally, I am an avid volunteer at a non-profit clinic giving back to those who can’t afford but deserve necessary treatments.”

[leedsomics]

Role of omics techniques in the toxicity testing of nanoparticles.

Related Articles Role of omics techniques in the toxicity testing of nanoparticles. J Nanobiotechnology. 2017 Nov 21;15(1):84 Authors: Fröhlich E Abstract Nanotechnology is regarded as a key technology of the twenty-first century. Despite the many advantages of nanotechnology it is also known that engineered nanoparticles (NPs) may cause adverse health effects in humans. Reports on toxic effects of NPs relay mainly on conventional (phenotypic) testing but studies of changes in epigenome, transcriptome, proteome, and metabolome induced by NPs have also been performed. NPs most relevant for human exposure in consumer, health and food products are metal, metal oxide and carbon-based NPs. They were also studied quite frequently with omics technologies and an overview of the study results can serve to answer the question if screening for established targets of nanotoxicity (e.g. cell death, proliferation, oxidative stress, and inflammation) is sufficient or if omics techniques are needed to reveal new targets. Regulated pathways identified by omics techniques were confirmed by phenotypic assays performed in the same study and comparison of particle types and cells by the same group indicated a more cell/organ-specific than particle specific regulation pattern. Between different studies moderate overlap of the regulated pathways was observed and cell-specific regulation is less obvious. The lack of standardization in particle exposure, in omics technologies, difficulties to translate mechanistic data to phenotypes and comparison with human in vivo data currently limit the use of these technologies in the prediction of toxic effects by NPs. PMID: 29157261 [PubMed - in process] http://dlvr.it/Q2R3DJ