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juniperpublishers-crdoj · 2 years ago

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Physical Activity, Exercise, Weight Reduction and Oxidative DNA Damage in Colorectal Cancer Risk Groups. Is there a Hormesis Relationship Between Risk Biomarkers and Lifestyle Factors?

Authored by H Allgayer

Abstract

Patients with obesity and/or type 2 diabetes have an increased tumor risk including colorectal cancer. Physical acrtivity (PA), exercise (EX) and weight reduction (WR) are effective strategies to decrease this risk. Highly sensitive tumor risk biomarkers such as oxidative DNA damage products (8-oxo-2’deoxyguanosine [8-oxo-dG]) increasingly are used in epidemiological and clinical (intervention) studies to better quantify this risk and to investigate potential effects of PA/EX/WR on this biomarker with the aim to further improve prevention and patient management programs. Based on the available data a U-shaped relationship between urinary 8-oxo-dG excretion and the level of PA/EX intensity is assumed, on the other hand, the relationship with BMI seems to be less clear. In this minireview this data will be discussed with regard to clinical and epidemiologic aspects.

Keywords: Type 2 diabetes; Obesity; Colorectal cancer; Weight reduction physical activity; Exercise; Oxidative DNA damage; 8-oxo-dG

Abbreviations: T2D: Type 2 Diabetes; CRC: Colorectal Cancer; BMI: Body Mass Index; PA/EX: Physical Activity/Exercise; 8-oxo-dG: 8-oxo-2’-Deoxy-Guanosine; ROS: Reactive Oxygen Species; ROM: Reactive Oxygen Metabolites; TTL: Total Thiol

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Introduction

Epidemiologic and clinical studies in the last three decades have convincingly demonstrated that patients with type 2 diabetes (T2D) have a higher tumor risk including colorectal cancer (CRC) and that CRC-patients with T2D have an elevated risk of a more aggressive disease course compared to non-diabetic individuals [1,2]. In addition, there is convincing evidence that elevated body mass index (BMI [kg/m2]) particularly visceral fat mass may also contribute to an increased tumor risk including CRC, whereas on the other side weight reduction was found to decrease this risk [3-5]. Physical activity/exercise (PA/EX) was shown to be associated in a dose-dependent and inverse relationship with a 30 to 50 percent lower decrease of tumor risk in the most active individuals [6]. To further improve prevention strategies and therapeutic management in risk groups more clinical and epidemiological studies with quantitative data using highly sensitive risk biomarkers and their modification by lifestyle factors are urgently needed.

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Disease, Oxidative DNA Damage Products and Risk Prediction Models

To quantify tumor risks (including CRC) a series of compounds modifiable by lifestyle factors (diet, PA/EX) have been proposed, among them 8-oxo-2’-deoxy-guanosine (8-oxo-dG) which was shown to reflect (mutagenic) oxidative DNA damage deriving from interactions with reactive oxygen species (ROS) produced in excess as a consequence of increased endogenous and exogenous oxidative stress [7,8]. Elevated levels of 8-oxo-dG have been found in many conditions and diseases with an increased cancer risk including T2D [9-14]. In a recently published clinical crosssectional study comparing urinary 8-oxo-dG in individuals with different CRC-risks we found that urinary excretion in patients with T2D (having a moderately elevated CRC risk) was in between those with curatively treated CRC (high risk for recurrence) and non-diabetic controls (average risk) [15]. Urinary excretion of 8-oxo-dG was significantly correlated with BMI (p=0.04) in all study participants, but not with the smoking status, age, alcohol consumption or gender. One clinically important application would be the implementation of stress biomarkers into predefined CRCprediction models to further improve accuracy with inclusion into appropriate prevention programs. Thus, in a recently published meta-analysis compiling the data of two large scale populationbased studies with >4000 individuals (ESTHER and Tromsö study) it was shown that the inclusion of reactive oxygen metabolites (ROM) assessed as total thiol (TTL) and hydrogen peroxide levels (d-ROM) into already existing models significantly improved their accuracy (C-statistics) [16]. Another study from the same group could show that CRC patients in the presence of elevated blood TTL and d-ROM levels had a poorer prognosis compared to those without these parameters [17]. Similar population-based trials with implementation of additional risk biomarkers such as urinary excretion levels of 8-oxo-dG into those prediction models presently are not available but are likely to further improve our prevention programs particularly in patients at an increased CRCrisk.

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Physical Activity/Exercise and Oxidative DNA Damage (8-oxo-dG)

Quantitative data concerning beneficial effects of PA/EX on the individual tumor risk in terms of risk biomarkers are clinically important, but not widely available and not entirely consistent. The great majority of clinical and experimental intervention studies in healthy volunteers as well as in patients belonging to risk groups such as T2D or curatively treated CRC have shown decreased systemic and urinary 8-oxo-dG levels (and other risk biomarkers) in the range of 20–30 percent following moderate intensity of EX, whereas at higher intensity levels oxidative DNA damage increased suggesting a U-shaped (hormesis) relationship. [18-25]. One possible explanation for this effect may be that cellular and humoral compensatory mechanisms such as exerciseinduced activation of antioxidant defenses (e.g., superoxide dismutase, DNA repair systems) would be exhausted at higher EX intensities with a shift to more prooxidant compounds [26-28]. In our recently published study [15] we found that urinary 8-oxo-dG excretion was independent of the individual level of PA in all study participants, an observation being somewhat surprising and in contrast to data from interventional studies mostly showing clear beneficial effects of regular exercise on genome stability and DNA damage in risk groups such as patients with T2D [19,20]. A possible explanation of this discrepancy may be that exercise-induced changes of 8-oxo-dG levels are closely linked to rapid changes of humoral and cellular redox systems [26,27] and that these rather short lived effects may have been missed in non-interventional settings such as our study, a view based on a closer look into the time protocols of these studies e.g times at which biomarkers had been assessed in relation to previous PA/ EX [15]. Despite these limitations further biomarker-guided longterm prospective interventional trials with individually tailored exercise programs are urgently needed to improve patient management particularly in those at increased CRC-risk such as obesity and T2D with particular emphasis on moderate intensity protocols to obtain optimal individual benefit.

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Body Mass Index and 8-oxo-dG

In contrast to PA/EX the relationship of BMI oxidative DNA damage seems to be less clear as there are studies reporting inverse (negative) as well as positive correlations [29-32]. In a longitudinal study investigating a cohort of 179 healthy office workers Mizoue et al. found a negative correlation up to BMI 27 kg/m2 [31], in morbidly obese patients undergoing bariatric surgery, however, a positive correlation was observed with a highly significant decrease 6 months after surgery [32]. Based on these data the authors of both groups suggested that there may possibly be a similar relationship of BMI with urinary 8-oxodG excretion as seen for PA/EX.; a negative correlation being observed at low/normal BMI (<27 kg/m2) turning positive above this value [31,32]. When the participants in our recently published study (T2D, CRC, non-diabetic controls) were analyzed separately according to their diagnosis the observed positive correlation (p=0.04) was no longer significant. Additional BMI-models with multiple adjustments for the cofactors gender, age, BMI, alcohol consumption and smoking status yielded similar results (no correlation) [15]. In line with this data are results of our earlier study showing no significant correlation of BMI with urinary 8-oxodG excretion in CRC-patients [21]. It is, therefore, important to adjust for multiple confounding factors, when correlations of BMI with 8-oxo-dG in clinical and/or epidemilogical studies are investigated. Despite these limitations oxidative DNA damage biomarkers should be included into weight reduction programs particularly for the obese/morbidly obese individuals and those in whom bariatric surgery is planned [32]. Our finding of a positive correlation of BMI with urinary 8-oxo-dG excretion (in the nondiabetic controls) may further support the view that long-term (beneficial) effects of PA (or energy expenditure during EX) on risk biomarkers may be mediated at least partially by the weight loss (BMI reduction) as observed during appropriate exercise programs.

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mainsiam · 3 years ago

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Avenue jean mermoz berlin

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J Gastrointest Surg 2012 16:2044–55īirnbaum DJ, Gaujoux S, Cherif R, et al. Parenchyma-sparing resections for pancreatic neuroendocrine tumors. Langenbecks Arch Surg 2011 396:313–21Ĭherif R, Gaujoux S, Couvelard A, et al. Surgical treatment of pancreatic endocrine tumours in Italy: results of a prospective multicentre study of 262 cases. Zerbi A, Capitanio V, Boninsegna L, et al. Trends in hospital volume and operative mortality for high-risk surgery. Dig Dis Sci 1991 36:933–42įinks JF, Osborne NH, Birkmeyer JD. Clinical pathology of endocrine tumors of the pancreas. Thésaurus national de cancérologie digestive. Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours. Gastrointestinal neuroendocrine tumors: pancreatic endocrine tumors. Consensus guidelines for the management of patients with liver metastases from digestive (neuro)endocrine tumors: foregut, midgut, hindgut, and unknown primary. Steinmuller T, Kianmanesh R, Falconi M, et al. NCCN clinical practice guidelines in oncology: neuroendocrine tumors. Pancreas 2010 39:735–52Ĭlark OH, Benson AB, Berlin JD, et al. NANETS treatment guidelines: well-differentiated neuroendocrine tumors of the stomach and pancreas. Kulke MH, Anthony LB, Bushnell DL, et al. In: Bosman FT, Carneiro F, Hruban RH, Theise ND (eds) WHO classification of tumors of the digestive system, 4th edition. Nomenclature and classification of neuroendocrine neoplasms of the digestive system. Microvascular density and hypoxia-inducible factor pathway in pancreatic endocrine tumours: negative correlation of microvascular density and VEGF expression with tumour progression. Gastroenterology 2003 125:1094–104Ĭouvelard A, O’Toole D, Turley H, et al. Low microvessel density is an unfavorable histoprognostic factor in pancreatic endocrine tumors. Marion-Audibert AM, Barel C, Gouysse G, et al. Neuroendocrine tumors of midgut and hindgut origin: tumor-node-metastasis classification determines clinical outcome. Prognostic factors and survival in 324 patients with pancreatic endocrine tumor treated at a single institution. Determining prognosis in patients with pancreatic endocrine neoplasms: can the WHO classification system be simplified? J Clin Oncol 2007 25:5609–15Įkeblad S, Skogseid B, Dunder K, et al. Gastroenterology 2007 132:899–904įerrone CR, Tang LH, Tomlinson J, et al. Survival from malignant digestive endocrine tumors in England and Wales: a populationbased study. Prognostic relevance of a novel TNM classification system for upper gastroenteropancreatic neuroendocrine tumors. Pape UF, Jann H, Muller-Nordhorn J, et al. Ki-67 index, tumor differentiation, and extent of liver involvement are independent prognostic factors in patients with liver metastases of digestive endocrine carcinomas.

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Prognostic factors at diagnosis and value of WHO classification in a monoinstitutional series of 180 non-functioning pancreatic endocrine tumours. J Clin Oncol 2011 29:3044–9īettini R, Boninsegna L, Mantovani W, et al. Prognostic validity of a novel American Joint Committee on Cancer Staging Classification for pancreatic neuroendocrine tumors. Metastatic and locally advanced pancreatic endocrine carcinomas: analysis of factors associated with disease progression. One hundred years after “carcinoid”: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. Sachs T, Pratt WB, Callery MP, Vollmer CM The incidental asymptomatic pancreatic lesion: nuisance or threat? J Gastrointest Surg 2009 13:405–15 Nonfunctioning pancreatic endocrine tumors: a multicenter clinical study. Pancreatic incidentalomas: high rate of potentially malignant tumors. Parenchyma-preserving resections for small nonfunctioning pancreatic endocrine tumors.

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irispublishersgynecology · 3 years ago

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Iris Publishers_World Journal of Gynecology & Womens Health (WJGWH)

COVID-19 Pandemic; Impact on the Colposcopy Service

Authored by Fani Gkrozou

Summary

Objectives: The COVID-19 pandemic caused by SARS-CoV-2 has radically changed global healthcare and colposcopy services are no exception. The aim of this study was to review the effect of COVID-19 pandemic on colposcopy services in a tertiary center.

Study design: A retrospective observational study was conducted in a tertiary center between March to August 2020. We included all women referred to our colposcopy services. The practice has been reviewed according to guidance from BSCCP.

Results: For high grade dyskaryosis referral, 64% of patients were offered an appointment within the target 2 week-wait time frame. For low grade dyskaryosis referral, 47% of patients were seen within the target 12-week timeframe.

Conclusions: The COVID-19 pandemic has resulted in longer waiting times for both high- and low-grade colposcopy referrals. This highlights the need for better preparation for potential future disruption of services and improvement of the existing service provided in order to support a faster and more efficient recovery from the pandemic.

Keywords: Colposcopy service; Covid 19 pandemic; Service provision

Introduction

In March 2020, the World Health Organization (WHO) declared the novel coronavirus disease 2019 (COVID-19) as a pandemic [1]. In the space of a few months after the start of the pandemic crisis, profound organizational changes have been adopted worldwide to optimize the healthcare facilities resources utilization.

Cervical cancer is the only one of the five gynaecological cancers to have an effective screening programme, however, during the COVID-19 pandemic, some of the 2 weeks wait cancer referrals were delayed or avoided when hospital’s capacity was particularly constrained, which affected cervical cancer prevention and management, including Human Papilloma Virus (HPV) vaccination, screening programme, colposcopy, and outpatient surgery.

A guidance by British Society for Colposcopy and Cervical Pathology [2] was put in place to triage patients who needed prompt evaluation in a colposcopy clinic including patients who had a high-grade smear, borderline nuclear change in endocervical cells, glandular neoplasia or suspicion of invasive disease [2]. Virtual consultations were advised for low grade referrals and for these patients to only be seen if resources permitted and to be deferred if colposcopy clinic capacity were reduced [2].

The aim of this study is to review the effect of the COVID-19 pandemic on colposcopy services in a tertiary center. We evaluated the process of patient selection in this tertiary unit’s colposcopy services during the pandemic benchmarked with Trust’s policy during the first wave of the pandemic and BSCCP guidelines. Our study will help understand the effect of such pandemic on our cervical cancer referral pathways to help plan our services in the future, especially should this pandemic result in a third wave of cases [3].

Materials and Methods

The colposcopy cases were undertaken at a United Kingdom (UK) teaching hospital trust, University Hospitals Birmingham NHS Foundation Trust, where colposcopy service runs at three hospital sites (Heartlands, Good Hope and Solihull Hospitals) from March 2020 to August 2020, during the first wave of the pandemic. That period, it was decided by Trust to offer appointments only to women with high grade cytology after smear test and with urgent referral from General Practitioner (GP). Results are presented for 151 patients referred with high grade dyskaryosis (group A) and 538 women with low grade cytology results (group B), from March 2020 to August 2020. Mean patient age at referral was 35.5±8.46 years, ranged (25-71) for group A and 35.4±9.31 years, ranged 24 to 66 years for group B.

Retrospective observational study on data from a populationbased cervical cancer screening database. This is the national database which is used to each colposcopy department in the UK and is provided by NHS England. For each patient information gathered regarding age, reason of referral/ smear result, histology result and treatment, when necessary, based on the information from colposcopy database. Steps in the screening process being disrupted (primary screening, surveillance, colposcopy, excisional treatment) were documented.

Baseline histology testing and delay in diagnosis were reported in patients referred for colposcopy. Categorical variables were presented as frequencies and percentages. It has to be mentioned that before the pandemic, our service was able to follow the national guidelines and keep the targets recommended by NHS England without any delays.

Precautions undertaken during COVID-19

Precautions undertaken for diagnostic and operative colposcopy were reviewed in line with Trust’s guidance and BSCCP guidelines including appropriate personal protective equipment (gloves, apron and appropriate mask) and minimum staff presence during procedures (BSCCP, 2020). BSCCP advised the avoidance of laser ablation and excision as well as use of coagulation procedures with diathermy due to vaporization [2]. For any large loop excision of transformation zone (LLETZ) procedure, the use of a serviced smoke extractor was advised [2]. For patients with symptoms suggestive of COVID-19 infection, colposcopy assessment was delayed until symptoms resolved, or patient tested negative. In accordance with our Trust’s policy, the number of women seen in colposcopy clinic had to be reduced by 5 for each clinic, to avoid unnecessary contact in waiting area. In addition, waiting area had to be reformed, to keep the rules for distance of two meters.

Results

High grade dyskaryosis colposcopy referrals

In total we had 151 patients referred with high grade dyskaryosis during this time period, out of which 149/151 (99%) attended. The commonest index cytology for referral was severe dyskaryosis 82/149 patients (55%) followed by moderate dyskaryosis 59/149 patients (40%). Three patients were referred directly due to suspected malignancy from cytology. Eight more patients were referred urgently with glandular cytology or post coital bleeding with known previous borderline cytology (Table 1).

Furthermore, we had 128/149 (86%) patients attending their first appointment compared to 21/149 (14%) of patients failing to attend. All patients that failed to attend their initial appointment were re-offered a second appointment date. Out of the 21 patients who did not attend their initial appointment date, 9/21 patients (43%) attended the second appointment date offered. 8/21 patients (38%) attended on their third appointment date offer. 4/21 patients (19%) were discharged back to their GP after failing to attend their second appointment date that was offered. On colposcopy database the reason of patient’s nonattendance was not documented.

Overall, 4/149 patients (3%) did not attend at all and were discharged back to their GP. All 149 patients who attended their appointments had a biopsy taken. The commonest histological finding was CIN 3 which was 67/149 patients (45%) followed by CIN 2, 29/149 patients (20%). Furthermore, we had 12/149 (8%) reported as CIN 1, and 41/149 (28%) were reported as cervicitis due to HPV changes or normal.

Out of the 149 patients with high grade cytology referrals, 9/149 patients (6%) were diagnosed with cancer. Five of these were offered an initial appointment within 2 weeks of referral and 4 patients had their first appointment date after 2 weeks of referral. Two patients failed to attend the first initial appointment that was offered. The average time from referral to patient being seen for these 9 patients was 35.8 days (Table 3).

For More Open Access Journals in Iris Publishers Please Click on: https://irispublishers.com/ For More Information:https://irispublishers.com/wjgwh/fulltext/covid-19-pandemic-impact-on-the-colposcopy-service.ID.000612.php

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brajeshupadhyay · 5 years ago

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Coronavirus Updates: China authorises emergency use of COVID-19 vaccines developed by Chinese companies

23:48 (IST)

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Trump pushes for COVID-19 treatments, claims slowdown at FDA

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The push on Sunday came a day after Trump tweeted sharp criticism on the process to treat the virus, which has killed more than 175,000 Americans and imperiled his re-election chances.

23:28 (IST)

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23:15 (IST)

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of COVID-19, this contagion has not even spared me. But, I am not showing any symptoms. My request to all please stay at home and follow the guidelines of the government," he tweeted. Mahapatra is now in home isolation at his Panskura residence in Purba Medinipur district, sources said.

PTI

22:44 (IST)

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coronavirus death toll to 610, a health bulletin said. The fresh infections have taken the total number of COVID-19 cases in the state to 1,22,155, it said. Patna district reported the highest number of new cases at 203, followed by Begusarai (159), Muzaffarpur (127), Bhagalpur (115) and Saharsa (120), the bulletin said.

22:15 (IST)

Coronavirus in China LATEST Updates

China approved emergency use of COVID-19 vaccines in July, says official

China has authorised emergency usage of COVID-19 vaccines developed by some select domestic companies, a Chinese health official has said. An emergency use authorisation, which is based on Chinese vaccine management law, allows unapproved vaccine candidates to be used among people who are at high risk of getting infected on a limited period. "We've drawn up a series of plan packages, including medical consent forms, side-effects monitoring plans, rescuing plans, compensation plans, to make sure that the emergency use is well regulated and monitored," Zheng Zhongwei, head of China's coronavirus vaccine development task force, told state-run CCTV on Saturday. One month has passed since China officially launched the urgent use of COVID-19 vaccines on 22 July, while the vaccines were going through clinical trials, Zheng said. Recipients who got their first dose since then revealed they had few adverse reactions and none reported a fever.

PTI

21:54 (IST)

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The man in the viral photo is seen pouring liquor in a glass from a bottle while sitting on a hospital bed while food items served in aluminium foil containers are in front of him. A handcuff is also seen dangling from his right wrist. Katras police station officer-in-charge Ras Bihari Lal identified the man as 30-year-old Shantu Gupta, who was arrested on the charges of extortion on Thursday and was forwarded to jail. As he tested positive for coronavirus infection, the police admitted him to the central hospital of Bharat Coking Coal Limited (BCCL), which was converted to a dedicated COVID19 facility, on Friday.

PTI

21:32 (IST)

Coronavirus in India LATEST Updates

Over 4,000 students go on hunger strike, demand exams be postponed

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Read full report here

21:09 (IST)

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PTI

20:52 (IST)

Coronavirus in Gujarat LATEST Updates

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PTI

20:35 (IST)

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Ripunjoy Kakoti and Roushan's wife were also afflicted with the disease, the officials said. Chetia and Kakoti were suffering from fever and cough and their swab samples were tested. Roushan and his wife tested positive for the infection during raping antigen tests and were advised home isolation, they said. Dhubri Superintendent of Police Anand Mishra hadtested positive for COVID-19 last week. A total of 3,310 Assam Police personnel, including Director General of Police Bhaskar Jyoti Mahanta, have tested positive for the infection till date. Eleven police personnel have died, while 2,698 have recovered and 601 are undergoing treatment, officials said.

PTI

20:22 (IST)

Coronavirus in Maharashtra LATEST Updates

Maharashtra reports 10,441 new cases, 258 deaths

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19:54 (IST)

Coronavirus in Assam LATEST Updates

Assam health minister launches first sero survey

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19:14 (IST)

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Delhi recorded 1,450 fresh coronavirus cases on Sunday, the highest single-day spike in August, taking the infection tally to over 1.61 lakh, while the death toll mounted to 4,300. Sixteen fresh fatalities were recorded in the last 24 hours, officials said. Sunday's spike in fresh cases surpassed Saturday's increase of 1,412 cases, authorities said. The total number of cases stood at 1,61,466. The bulletin said that the number of active cases stood at 11,778, while 1,45,388 patients have either recovered, been discharged or migrated out.

PTI

19:09 (IST)

Coronavirus in Tamil Nadu LATEST Updates

Tamil Nadu reports 5,975 new cases, 97 deaths

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18:16 (IST)

Coronavirus in Delhi LATEST Updates

Delhi govt has requested Centre to allow resumption of Metro, says CM

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17:56 (IST)

Coronavirus in Delhi LATEST Updates

COVID-19 situation in Delhi under control, says Kejriwal

Delhi Chief Minister Arvind Kejriwal said that the COVID-19 situation in Delhi was under control, adding that it is "perhaps the only city" in the country where a lockdown was not re-imposed. "I am happy that with the help of everyone, the COVID-19 situation in the National Capital is under control now. The way Delhi has been dealing with COVID-19 situation is being discussed in the country as well as across the world," he said.

We imposed lockdown in Delhi only once, and then gradually resumed work across fields from June 1 onwards. Probably, Delhi is the only city where lockdown hasn't been imposed again, as we understand work & COVID management can go hand-in-hand: Delhi Chief Minister Arvind Kejriwal pic.twitter.com/VWktQbCwxp

— ANI (@ANI) August 23, 2020

17:38 (IST)

Coronavirus in India LATEST Updates

India could get COVID-19 vaccine by year-end if everything goes well: Harsh Vardhan

Union Health Minister Dr Harsh Vardhan has said that if everything goes well, India would get a vaccine against the novel coronavirus by the end of this year. Three COVID-19 vaccine candidates, including two indigenous ones, are in different phases of development in India. The phase-one human clinical trials of the two indigenous COVID-19 vaccine candidates, one developed by Bharat Biotech in collaboration with ICMR and the other by Zydus Cadila Ltd, have been completed and the trials have moved to phase-two, ICMR Director General Dr Balram Bhargava had said recently. The Serum Institute of India, which has partnered with AstraZeneca for manufacturing the COVID-19 vaccine candidate developed by the University of Oxford has been permitted for conducting its phase two and three human clinical trials in India. It is likely to start the trials next week.

कब तक आएगी #कोरोना की #vaccine ? पत्रकारों के इस सवाल पर मैंने उम्मीद जताई क�� अगर सब कुछ ठीक रहा तो भारत इस साल के आखिर तक #coronavaccine हासिल कर लेगा। @MoHFW_INDIA @CSIR_IND @NDRFHQ pic.twitter.com/zqAxftKUdt

— Dr Harsh Vardhan (@drharshvardhan) August 22, 2020

17:21 (IST)

Coronavirus in Madhya Pradesh LATEST Updates

Madhya Pradesh health minister says he tested COVID-19 positive

Madhya Pradesh Health Minister Prabhuram Choudhary on Sunday said he has tested coronavirus positive. "My COVID-19 test report came out positive. I request those who had come in my contact to undergo a coronavirus test. Those in close contact should quarantine themselves," he tweeted. "With your prayers and blessings, I will return amidst you soon to serve the people," he said.

Choudhary is the seventh minister in Madhya Pradesh, besides Chief Minister Shivraj Singh Chouhan, to test positive for the infection. In the last week of July, CM Chouhan had tested positive and recovered after treatment.

PTI

मेरी कोविड की रिपोर्ट टेस्ट के बाद पॉजि़टिव आई है।मेरा सभी से निवेदन है जो भी मेरे संपर्क में आए हैं, वह कोरोना टेस्ट करवा लें। मेरे निकट संपर्क वाले लोग क्वारनटीन में चले जाएं।आप सभी की प्रार्थना एवं आशीर्वाद से जल्द आप सभी के बीच उपस्थित होकर फिर जन सेवा के कार्यों में लगेंगे।

— Dr. Prabhuram Choudhary (@DrPRChoudhary) August 23, 2020

17:06 (IST)

Coronavirus in Uttar Pradesh LATEST Updates

COVID-19 toll in Uttar Pradesh climbs to 2,926

Fifty-nine people succumbed to COVID-19 in Uttar Pradesh on Sunday, raising the toll due to the disease to 2,926 in the state, Additional Chief Secretary Amit Mohan Prasad said. Briefing reporters, the official said the case fatality rate stands at 1.56 percent. As many as 5,325 fresh coronavirus cases were reported in the state, taking the state-wide tally to 1,87,781, he said. So far, 1,35,613 COVID-19 patients have been discharged after recovering from the disease with the recovery rate at 72.21 percent, he further said. The count of active cases in the state stands at 49,242.

The senior official said 1.3 lakh samples were tested in UP on Saturday.

PTI

16:33 (IST)

Coronavirus in India LATEST Updates

Recovery rate nears 75%, says health ministry

A steadily increasing number of recoveries has pushed India's recovery rate to nearly 75 percent, said the Union health ministry. With 57,989 COVID-19 patients recuperating in the last 24 hours, the total number of recoveries has reached 22,80,566. The total recoveries in the country now exceed the total active cases (7,07,668) by nearly 16 lakhs (1,572,898), it said in a statement. Active cases now comprise 23.24 percent of the country's total case load, it said. "This has also resulted in a gradually falling mortality rate. Currently at 1.86 percent, India's case fatality rate (CFR) is one of the lowest globally," the ministry said.

The ministry said the average daily number of recoveries is on a "constant upward move" from 15,018 between July 1 and 7 to 60,557 between August 13 and 19.

India’s total recoveries now exceed the total active cases (7,07,668) by nearly 16 lakhs (1,572,898): Ministry of Health https://t.co/upgE9GQ4YF

— ANI (@ANI) August 23, 2020

16:12 (IST)

Coronavirus in India LATEST Updates

India has conducted around 3,52 crore COVID-19 tests so far, says health ministry

Testing over eight lakh samples for six days in a row, India's total COVID-19 tests have touched 3.52 crore, while the average daily positivity rate has come down from 9.67 per cent during August 3-9 to 7.67 pc over the last week, the Centre said on Sunday. So far, 3,52,92,220 samples have been tested for detection of COVID-19 with 8,01,147 being tested on Saturday.

The steep rise in testing is a result of effective implementation of the aggressive testing strategy of the Centre through a focussed and graded approach, the ministry said. "The rising average daily tests during the past three weeks present a strong depiction of the progress made in the enhancement of COVID-19 tests across the country. The rise in daily testing has been followed by a decrease in the average daily positivity rate," the health ministry highlighted. Keeping a sharp focus on the 'test, track and treat' policy, tests per million population have seen a boost, touching 25,574 as on date, it further stated.

15:43 (IST)

Coronavirus in Puducherry LATEST Updates

No e-pass required to travel to and from Puducherry

E-passes are not required to travel to and from Puducherry, announced the Union Territory administration today, reports ANI.

15:18 (IST)

Coronavirus in Singapore LATEST Updates

New COVID-19 cluster reported at Singapore's biggest dormitory

A new COVID-19 cluster has been reported in Singapore's biggest dormitory housing foreign workers, including Indian nationals, about a month after it was declared to be fully cleared of the coronavirus.

Two of the new COVID-19 cases reported in Singapore on Saturday were linked to 55 previous cases to form a new cluster at Sungei Tengah Lodge dormitory at 500 Old Choa Chu Kang Road, the Ministry of Health (MOH) said.

The cluster at Sungei Tengah Lodge was among the largest in Singapore before the dormitory was declared cleared of COVID-19 by the Ministry of Manpower (MOM) on Jul 21, the Channel News Asia reported.

15:01 (IST)

Coronavirus in India LATEST Updates

RTI finds 1.78 crore rail tickets cancelled in five months due to COVID-19

The Railways has cancelled more than 1.78 crore tickets since March this year due to the coronavirus pandemic and refunded an amount to the tune of Rs 2,727 crore, a RTI has found.

The RTI has found that the Railways, which had suspended its passenger train services since 25 March, cancelled 1,78,70,644 tickets.

PTI has earlier reported how perhaps for the first time the Railways has refunded more than it has earned from ticket bookings, registering a negative passenger segment revenue of Rs 1,066 crore in the COVID-19-hit first quarter of 2020-21.

14:35 (IST)

Coronavirus in Gujarat LATEST Updates

Homeopathic drug given to half of Gujarat population since March

The Gujarat health department has said it distributed homeopathic drug Arsenicum Album-30 to more than half of the state's population as prophylaxis since March after the outbreak of COVID-19, reports PTI.

In its presentation made before the World Health Organisation on August 20 on Gujarat's COVID-19 prevention strategy, the health department said it distributed Arsenicum Album-30 to 3.48 crore people, which is more than half of the state's population of 6.6 crore.

There is no scientific evidence that the drug works against COVID-19, a fact stressed not only by medical scientists but by some homeopathic practitioners themselves.

13:51 (IST)

Coronavirus in India LATEST Updates

Media reports over availability of COVID-19 vaccine are false, says Serum Institute of India

Serum Institute of India clarified on Sunday that the current claims over COVISHIELD's availability, in the media are completely false and conjectural.

"Presently, government has granted us permission to only manufacture the vaccine and stockpile it for future use." the company said, reports ANI.

"COVISHIELD will be commercialized once trials are proven successful & requisite regulatory approvals are in place. Phase-3 trials for Oxford-AstraZeneca vaccine are underway. Only once vaccine is proven immunogenic & efficacious,SII will confirm its availability officially," the company said.

A Business Today report had said that India's first Covid vaccine-Serum Institute's 'Covishield'- will be commercialised in 73 days.

13:43 (IST)

Coronavirus Outbreak LATEST Updates

Children aged 12 and older should wear masks, says WHO

Children aged 12 and older should wear masks like adults while those aged 6-11 should wear them on a “risk-based approach”, the World Health Organisation has said, reports moneycontrol.

Risk-based approach includes considerations such as intensity of transmission in the area, the child's ability to use masks, access to masks, adequate adult supervision, potential impact on learning and psycho-social development and interactions with people at high risk of developing serious illness, the organisation said in a United Nations Children's Fund (UNICEF) document uploaded on August 21.

13:13 (IST)

Coronavirus in Odisha LATEST Updates

Odisha reports record 2,993 COVID-19 cases, 10 more deaths

Odisha on Sunday registered its highest single-day spike of 2,993 COVID-19 cases and 10 more deaths due to the infection. With this, the state's COVID-19 death toll has mounted to 409 and the infection tally reached 78,530, a health official said.

Fifty-three other coronavirus patients have also died, but the cause of their deaths was attributed to some other reasons. Of the new 2,993 cases, 1,879 were reported from different quarantine centres, while the remaining 1,114 were detected during contact tracing, he said.

The state had last reported its highest single-day surge of 2,924 cases on 15 August.

12:57 (IST)

Coronavirus in India LATEST Updates

No change in Pranab Mukherjee's health, says hospital

There is no change in the health of former President Pranab Mukherjee and he continues to remain on ventilator support, the Army''s Research and Referral hospital told PTI on Sunday. Doctors attending on the 84-year-old Mukherjee said his vital parameters are stable.

Mukherjee was admitted to the hospital in Delhi Cantonment on 10 August and was operated for removal of a clot in the brain. He had also tested positive for COVID-19.

12:51 (IST)

Coronavirus in India LATEST Updates

Prakash Javadekar announces SOPs for resuming film, TV shooting

According to Hindustan Times, Union information and broadcasting minister Prakash Javadekar on Sunday said film and television programme production can be resumed with all the necessary health protocols in place amid Covid-19 pandemic.

After consultation with the home ministry and the health ministry, a standard operating procedure (SOP) has been firmed up, he said. According to the SOP, the actors facing the camera will be exempt from wearing masks. And crew members will have to adhere to the guidelines of the health ministry, reports NDTV.

Read full report here

12:48 (IST)

Coronavirus in Puducherry LATEST Updates

412 new COVID-19 cases push total to 10,522 in Puducherry

The COVID-19 tally in the union territory rose to 10,522 and the toll mounted to 159 with the addition of 412 fresh cases and eight deaths, the Health Department said on Sunday. There were 3,706 active cases after the discharge of 350 patients in the last 24 hours ending at 10 AM.

The cumulative recoveries stood at 6,657, Director of Health and Family Welfare S Mohan Kumar said in a release here. A total of 1,282 samples were tested during the period.

12:37 (IST)

Coronavirus Outbreak Latest Updates

Experts flag risks in India's use of rapid tests for virus

In June, India began using cheaper, faster but less accurate tests to scale up testing for the coronavirus — a strategy that the United States is now considering.

But India’s experience also highlights the inherent pitfalls of relying too heavily on antigen tests, at the expense of more accurate tests. The danger is that the tests may falsely clear many who are infected with COVID-19, contributing to new spread of the virus in hard-hit areas.

Rapid test results can be backstopped with more accurate laboratory tests, but these are slower and expensive. Experts also warn that since the two types of tests vary in accuracy, they need to be interpreted separately to properly assess the spread of infection -- something India isn’t doing.

12:22 (IST)

Coronavirus in Telangana Latest Updates

2,384 new cases in Telangana

The total number of coronavirus cases in Telangana rose to 1,04,249 after 2,384 new infections were reported on Saturday. The total number of cases includes 22,908 active cases, 80,586 recoveries and 755 deaths.

11:44 (IST)

Coronavirus in Uttar Pradesh LATEST Updates

Three COVID-19 patients untraceable in UP's Muzaffarnagar

Three people who tested COVID-19 positive in Uttar Pradesh's Muzaffarnagar district cannot be traced as they provided fake information and phone numbers during sample collection, officials said on Sunday.

Two of them claimed to be staffers of a hospital here, while the third person had given his address as Saket Colony, they said.

Health teams went to Saket Colony on Friday and to the hospital mentioned by the other two persons on Saturday to take them for treatment at a medical facility, the officials said. It was found that they had provided fake information, Chief Medical Officer Dr Praveen Chopda said.

11:37 (IST)

Coronavirus in Rajasthan LATEST Updates

Rajasthan reports 697 new cases, 6 deaths today

Rajasthan reports 697 new COVID-19 cases and 6 deaths today, taking the total cases to 69,961 including 950 deaths, 54,252 recoveries and 14,759 active cases

Rajasthan reports 697 new #COVID19 cases and 6 deaths today, taking the total cases to 69,961 including 950 deaths, 54,252 recoveries and 14,759 active cases: State Health Department pic.twitter.com/gr4k8lCXqK

— ANI (@ANI) August 23, 2020

11:35 (IST)

Coronavirus in Assam LATEST Updates

Weekend lockdown being observed in Guwahati today

Assam: Weekend lockdown being observed in Guwahati to control the spread of #COVID19. pic.twitter.com/yhEPWKlCvq

— ANI (@ANI) August 23, 2020

11:02 (IST)

Coronavirus in Maharashtra LATEST Updates

Thane district reports 1,284 new COVID-19 cases, 26 deaths

The number of COVID-19 cases in Maharashtra's Thane district has gone up to 1,13,884 with 1,284 more people testing positive for the disease, a health official told PTI on Sunday. The fatality count in the district has reached 3,240 as 26 more people succumbed to the viral infection on Saturday, he said.

10:33 (IST)

Coronavirus in India LATEST Updates

India's COVID-19 recovery rate rises to 74.9%

India's COVID-19 tally sprinted past the 30-lakh mark, just 16 days after it crossed 20 lakh, while 22,80,566 people have recuperated in the country so far pushing the recovery rate to 74.90 per cent, according to the Union Health Ministry data.

With a single-day spike of 69,239 infections, the country's COVID-19 caseload mounted to 30,44,940, while the death toll climbed to 56,706 with 912 fatalities being reported in a span of 24-hours, the data updated at 8 am showed.The COVID-19 case fatality rate has declined to 1.86 percent.

There are 7,07,668 active cases of coronavirus infection in the country which comprises 23.24 per cent of the total caseload, the data stated.

10:24 (IST)

Coronavirus in India LATEST Updates

ICMR says over 8.1 lakh samples tested yesterday

The Indian Council of Medical Research (ICMR) has said that 3,52,92,220 samples were tested for COVID-19 in the country till yesterday (August 22). Of these, 8,01,147 were tested yesterday.

09:55 (IST)

Coronavirus in Uttar Pradesh LATEST Updates

23 people test positive for COVID-19 in UP's Shamli district

The number of active COVID-19 cases in Uttar Pradesh's Shamli district has increased to 150 with 23 people testing positive for the infection, officials told PTI on Sunday. The district also reported a death from the novel coronavirus and the toll now stands at 15, they said.

"Twenty-three people have tested positive for COVID-19. Their reports were received on Saturday evening. On the same day, six patients recovered," District Magistrate Jasjit Kaur said. The officials said that a woman from Thanabhawan town died at a hospital on Saturday, taking the death toll to 15 in the district.

09:35 (IST)

Coronavirus in India LATEST Updates

India's COVID-19 total crosses 30 lakh with over 56,000 deaths

India’s coronavirus tally on Sunday breached the 30-lakh mark after the country reported 69,239 new cases in the last 24 hours. The country’s toll rose by 912 to 56,706. Of the overall tally of 30,44,940, India now has 7,07,668 active cases while more than 22 lakh people have recovered from the infection

09:07 (IST)

Coronavirus in Jharkhand LATEST Updates

Jharkhand Agriculture Minister Badal Patralekh tests COVID-19 positive

सभी राज्यवासियों को जोहार, मैंने कल अपना कोरोना जांच कराया, जिसकी रिपोर्ट देर रात्रि पॉजिटिव आई हैं।विगत कुछ दिनों में जो भी लोग मेरे संपर्क में आये हैं उनसे विनम्र अनुरोध है कि अपनी जांच करा लें। आप सभी से अनुरोध हैं घर पर रहे सुरक्षित रहें।

— Badal (बादल) (@Badal_Patralekh) August 23, 2020

09:05 (IST)

Coronavirus in Uttar Pradesh LATEST Updates

Weekend lockdown being observed in Prayagraj today

Weekend lockdown being observed in Prayagraj, to curb the spread of #COVID19 pic.twitter.com/fjj4uHqCXG

— ANI UP (@ANINewsUP) August 23, 2020

08:55 (IST)

Coronavirus in Assam LATEST Updates

Toll due to COVID-19 rises to 234 in Assam

The toll in Assam due to the pandemic rose to 234 with seven more succumbing to it, Health and Family Welfare Minister Himanta Biswa Sarma said on Saturday. The seven deceased are from Jorhat, Dibrugarh, Cachar, Kamrup, Sonitpur and Kamrup Metropolitan districts, Sarma tweeted.

The persons affected included a 77-year-old from Kamrup Metropolitan district, which primarily cinsists of the Guwahati city. The others are a 77-year-old and a 60-year old from Dibrugarh district the fourth one is a 46-year old man from Jorhat, Sarma said.

Three more persons aged 63 years, 55 years and 60 years of age lost their lives in Cachar, Kamrup and Sonitpur districts respectively, he added.

#AssamPlasmaHero ~ Aug 21 5. Pratim Talukdar (38), Ganakpara, Azara/ GMCH 6. Surajit Kalita (36), Pathsala, Barpeta/ GMCH 7. Prafulla Deka (53), Guwahati/ MMCH 8. Dr Biswajit Haloi (34)/Narayan Hospital Gratitude 🙏 pic.twitter.com/oAozWZRbGS

— Himanta Biswa Sarma (@himantabiswa) August 22, 2020

08:18 (IST)

Coronavirus in Indian LATEST Updates

Sharp rise in recoveries and recovery rate key to India's success against COVID-19, says Centre

#CoronaVirusUpdates The key to India's success in its fight against #COVID19: consistently and sharply rising recoveries and Recovery Rate.@PMOIndia @drharshvardhan @AshwiniKChoubey @PIB_India @DDNewslive @airnewsalerts @COVIDNewsByMIB @ICMRDELHI @mygovindia @CovidIndiaSeva pic.twitter.com/NRPPMB1xUs

— Ministry of Health (@MoHFW_INDIA) August 23, 2020

07:49 (IST)

Coronavirus in Italy LATEST Updates

Italy sees over 1,000 new coronavirus cases in a day

Italy recorded 1,071 new cases of the novel coronavirus in the last 24 hours, the worst daily number since lockdown was lifted in May, the health ministry reported on Saturday.

The ministry's figures showed that three people died from disease caused by the virus, bringing total deaths to 35,430 in Italy since the pandemic began. Total infections number 258,136.

07:40 (IST)

Coronavirus in Odisha LATEST Updates

Odisha's COVID-19 total climbs up to over 75,000 cases

Odisha's COVID-19 tally rose to 75,537 on Saturday with the detection of 2,819 fresh infections, while nine more fatalities pushed its coronavirus death toll to 399, a health official told PTI.

Three fresh fatalities were registered in Cuttack, two in Sundargarh and one each in Bolangir, Ganjam, Malkangiri and Rayagada districts, he said.

The fresh COVID-19 cases were reported from 29 of the 30 districts of the state.

07:36 (IST)

Coronavirus LATEST Updates

World virus deaths top 8,00,000 as nations ramp up measures

The global toll from the new coronavirus has surpassed 800,000, according to an AFP count on Saturday, with numerous countries ramping up restrictions in an effort to battle an eruption of new cases.

Western Europe, particularly Spain, Italy Germany and France, has been enduring infection levels not seen in many months, sparking fears of a fully-fledged second wave.

And in Asia, South Korea, which had largely brought the virus under control, became the latest country to announce it would boost restrictions to try to stem a new outbreak.

Across the world, the number of deaths has doubled to just over 800,000 since June 6, with 100,000 fatalities in the last 17 days alone, while more than 23 million cases have been registered.

Coronavirus LATEST Updates: China has authorised emergency usage of COVID-19 vaccines developed by some select domestic companies, a Chinese health official has said.

The first serological survey in Assam was launched by the Minister of state for Health and Family Welfare Pijush Hazarika on Sunday to assess whether people surveyed have developed immunity to novel coronavirus.

Children aged 12 and older should wear masks like adults while those aged 6-11 should wear them on a 'risk-based approach', the World Health Organisation has said

According to the SOP, the actors facing the camera will be exempt from wearing masks. And crew members will have to adhere to the guidelines of the health ministry

Of the overall tally of 30,44,940, India now has 7,07,668 active cases while more than 22 lakh people have recovered from the infection

India's coronavirus case count raced past 30 lakh on Saturday, showed an unofficial tally based on information provided by staes and Union territories, while the toll rose to 56,762 and recoveries climbed to 22,71,054.

India is the third-worst affected country by the viral infection, said news agency PTI, which compiled the data.

The virus has claimed over eight lakh lives globally.

However, according to data released by Union Ministry of Health and Family Welfare on Saturday morning, the overall case count in India has climbed to 29,75,701 with the country recording its highest single-day spike of 69,874 new coronavirus cases. The toll climbed to 55,794 with 945 fatalities being reported in a span of 24 hours, the data updated at 8 am showed.

But the number of recoveries also surged to 22,22,577 pushing the recovery rate to 74.69 percent on Saturday while the fatality rate dipped to 1.87 percent, said the ministry.

India on Saturday also crossed the significant milestone of having conducted over 10 lakh tests in a day for the detection of the novel coronavirus, with more than 3.44 crore such tests conducted so far.

The COVID-19 case count in Telangana crossed the one-lakh mark with 2,474 new cases while the toll touched 744. In Jharkhand, Chief Minister Hemant Soren said his father, veteran Jharkhand Mukti Morcha leader Shibu Soren, and his mother Roopi, tested positive for the viral infection and are placed in home quarantine.

Recoveries exceed active cases by 15 lakh, says health ministry

The home ministry, in its morning update, said that there are 6,97,330 active cases of coronavirus infection in the country, comprising 23.43 percent of the total caseload in the country.

While the country's COVID-19 case count has surged to 29.75 lakh, the total number of recoveries has surged to 22,22,577 and exceed active cases by over 15 lakh as on date, it said.

Union Health Minister Harsh Vardhan, at the inauguration of a make-shift NDRF hospital in Ghaziabad, said that India has the "best" COVID-19 recovery rate, which is improving every day, and the "lowest" mortality rate in the world.

Taking a potshot at government critics, Vardhan said "many intelligent people, scientists and naysayers" had estimated that India, with a population of about 135 crore, will see 30 crore COVID-19 cases and about 50-60 lakh people will die by July-August, and the country's healthcare system was "incapable" to combat the disease.

"However, I am happy to say that in the eighth month of the battle, India has the best recovery rate of 75 percent and against an estimate of 30 crore affected we have not even reached 30 lakh cases."

"In fact, 22 lakh patients have recovered and gone home and another seven lakh are going to be cured very soon," he said.

The minister said these successes were achieved due to the "coordinated" efforts with the participation of everyone — the government and the people.

Centre asks states to ensure unrestricted movement of goods, people

Meanwhile, the Centre asked all states to ensure that there are no restrictions on inter-state and intra-state movement of persons and goods during the ongoing unlocking process. In a communication to chief secretaries of all states and Union Territories, Union Home Secretary Ajay Bhalla said there were reports that local level restrictions on movement were being imposed by various districts and states.

Drawing attention to the Unlock-3 guidelines, Bhalla said such restrictions are creating problems in inter-state movement of goods and services and are impacting supply chains, resulting in disruption of economic activity and employment.

The unlock guidelines clearly state that there shall be no restrictions on inter-state and intra-state movement of persons and goods, he said in the letter. The guidelines also stated that no separate permission, approval or e-permit will be required for movement of persons and goods for cross land border trade under treaties with neighbouring countries.

The home secretary said the restrictions amount to violation of the guidelines issued by Ministry of Home Affairs under provisions of Disaster Management Act, 2005.

JMM chief Shibu Soren tests positive

Rajya Sabha MP and Jharkhand Mukti Morcha (JMM) president Shibu Soren and wife Roopi have tested positive for COVID-19, his son and Jharkhand chief minister Hemant Soren said.

Taking to Twitter, the chief minister said "respected father Dishom Guru ji" and mother were diagnosed with the disease on Friday night, and they are undergoing home quarantine. The 76-year-old president of the ruling JMM in the state is revered as 'guruji' (master) by his followers.

कल रात आदरणीय बाबा दिशोम गुरु जी और माँ की कोरोना संक्रमण रिपोर्ट पॉजिटिव आयी। वे दोनों होम आइसोलेशन में हैं और स्वास्थ्य लाभ ले रहे हैं।

देश और झारखण्डवासियों की दुआओं के साथ जल्द ही आदरणीय बाबा और माँ ��म सभी के बीच होंगे।

— Hemant Soren (घर में रहें - सुरक्षित रहें) (@HemantSorenJMM) August 22, 2020

// <![CDATA[ <script> // ]]> "With the blessings of the people of Jharkhand and the entire country, they will soon be among us, the CM tweeted.

Seven other members of the JMM chief's household have also tested positive for the viral infection, reported news agency PTI quoting official sources.

The chief minister, who lives at his official residence, close to the JMM chief's government bungalow, will undertake the test on Monday -- third time in two months. Earlier, Hemant had taken the test on two separate occasions — first time after coming in contact with infected Cabinet colleague Mithilesh Thakur, and the second time after 17 employees at his office were diagnosed with the disease.

On Tuesday, state health minister Banna Gupta was diagnosed with the disease.

Punjab minister tests positive

In Punjab, Chief Minister Amarinder Singh said that Cooperation and Jails Minister Sukhjinder Singh Randhawa has tested positive for COVID-19.

"I wish him a speedy recovery and look forward to him joining us at work soon," said Singh.

My Cabinet colleague and Cooperation & Jails Minister Sukhjinder Singh Randhawa has tested positive for #Covid19. I wish him a speedy recovery and look forward to him joining us at work soon.

— Capt.Amarinder Singh (@capt_amarinder) August 22, 2020

// <![CDATA[ <script> // ]]>

Former Chief Minister Parkash Singh Badal's residence in Muktsar district was declared as a micro containment zone after five security personnel posted there tested positive, a health official told PTI.

Punjab on Saturday reported 45 deaths and 1,320 fresh infections, pushing the death count to 1,036 and total infections to 40,643.

Telangana's case count crosses one lakh

Telangana's overall case count rose to 1,01,865 as 2,474 new cases were added. With seven more people succumbing to the virus, the toll in the state mounted to 744. However, the state's recovery rate at 77.29 percent was higher than the country's recovery rate of 74.69 percent.

Maharashtra, Andhra Pradesh, Gujarat and West Bengal were among the other states which added high numbers to their case tallies.

While Maharashtra reported 14,492 new cases and 297 deaths, Andhra Pradesh reported over 10,000 fresh infections. The overall count in the southern state climbed to 3,45,216 and the toll mounted to 3,189.

Gujarat its highest single-day spike of 1,212 new COVID-19 cases, taking the total count of infections to 85,678, the state health department said. The number of fatalities rose by 14, including six in Surat, which is the highest in the state, to 2,883, it said.

A total of 980 patients were discharged in the day, taking the number of recoveries to 68,257, the department said, adding that the recovery rate has reached 80 percent.

With a record 3,232 new cases in a single day, West Bengal's caseload went up to 1,35,596. The toll reached 2,737 with 48 more people succumbing to the disease, said a bulletin issued by the state health department.

With inputs from agencies

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cancersfakianakis1 · 6 years ago

Text

Programmed Death Ligand-1 expression in stage II colon cancer - experiences from a nationwide populationbased cohort

Abstract

Background

Patients suffering from high risk stage II colon cancer (CC) may benefit from adjuvant onco-therapy, but additional prognostic markers are needed for better treatment stratification. We investigated the prognostic value of Programmed Death Ligand-1 (PD-L1) in a true population-based cohort of patients with stage II CC.

Methods

PD-L1 expression on tumour cells was evaluated by immunohistochemistry in 572 colon cancers. Whole sections from tumour blocks representing the deepest invasive front of the primary tumour were used for analysis. A cut-off of 5% positivity was used for dichotomizing the data. The prognostic value was investigated in Cox proportional hazard models for recurrence-free survival (RFS) and overall survival (OS).

Results

Overall, 6% of the tumours were classified as high PD-L1. High PD-L1 was related to female gender (p = 0.028), high malignancy grade (< 0.001), right side localization (p < 0.001) and microsatellite instability (MSI) (p < 0.001). Thirty-one (18%) of the MSI and 4 (1%) of the microsatellite stable tumours were classified as high PD-L1, respectively. PD-L1 expression provided no prognostic value as a single marker. In patients with MSI tumours, high PD-L1 expression had no significant impact regarding OS or RFS.

Conclusions

PD-L1 expression in tumour cells of stage II CC did not provide any prognostic impact, neither in the entire population-based cohort nor in the group of MSI patients. Additional investigations of the immunogenic microenvironment are needed for evaluating the prognostic information in CC.

http://bit.ly/2RY7EtR

#Oncology-Sfakianakis

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narcbrain · 6 years ago

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Role of pre-existing adversity and child maltreatment on mental health outcomes for children involved in child protection: Population-based data linkage study

Via a longitudinal, population-based record-linkage study of all children in Western Australia with birth records between 1990 and 2009, the experts discovered mental health outcomes for children with a history of child protection system involvement, accounting for pre-existing adversity, and investigated alteration in risk across diagnostic groupings and child protection subgroups. Children…

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#Adversity #Child #Children #Data #health #Involved #linkage #maltreatment #Mental #Outcomes #Populationbased #preexisting #protection #Role #study

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extrapushut-blog · 8 years ago

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Sources

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brajeshupadhyay · 5 years ago

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23:48 (IST) Coronavirus in US LATEST Updates Trump pushes for COVID-19 treatments, claims slowdown at FDA Pushing for breakthroughs in treatments for the coronavirus, White House officials suggested Sunday there were politically motivated delays by the Food and Drug Administration (FDA) in approving a vaccine and therapeutics for the disease. The accusations, the latest assault from President Donald Trump’s team on the so-called “deep state” bureaucracy, were presented without evidence and just hours before Trump was set to hold a news conference to announce an apparent advancement in therapeutics. “This president is about cutting red tape,” said White House chief of staff Mark Meadows. “He had to make sure that they felt the heat. If they don’t see the light, they need to feel the heat because the American people are suffering.” The push on Sunday came a day after Trump tweeted sharp criticism on the process to treat the virus, which has killed more than 175,000 Americans and imperiled his re-election chances. AP 23:28 (IST) Coronavirus in Tamil Nadu LATEST Updates Tamil Nadu inaugurates second plasma bank Tamil Nadu Health Minister Vijayabaskar on Sunday inaugurated a plasma bank at a government hospital, the second in the state, to treat COVID-19 patients. The Rs 25 lakh facility is established with an aim to collect and store plasma from those who have recovered from the disease and help coronavirus patients recuperate quickly, he said. Last month, the government set up the first plasma bank at the Rajiv Gandhi Government General hospital in Chennai. 23:15 (IST) Coronavirus in West Bengal LATEST Updates West Bengal minister tests positive West Bengal Environment Minister Soumen Mahapatra on Sunday said he has tested positive for COVID-19. Stating that he is asymptomatic, the minister urged people who had come in contact with him recently to be in home isolation. "In the present alarming situation due to the outbreak of COVID-19, this contagion has not even spared me. But, I am not showing any symptoms. My request to all please stay at home and follow the guidelines of the government," he tweeted. Mahapatra is now in home isolation at his Panskura residence in Purba Medinipur district, sources said. PTI 22:44 (IST) Coronavirus in Bihar LATEST Updates Bihar's case count climbs to 1.22 lakh Bihar's COVID-19 caseload rose to 1.22 lakh on Sunday as 2,247 more people tested positive for the infection, while nine fresh fatalities pushed the state's coronavirus death toll to 610, a health bulletin said. The fresh infections have taken the total number of COVID-19 cases in the state to 1,22,155, it said. Patna district reported the highest number of new cases at 203, followed by Begusarai (159), Muzaffarpur (127), Bhagalpur (115) and Saharsa (120), the bulletin said. 22:15 (IST) Coronavirus in China LATEST Updates China approved emergency use of COVID-19 vaccines in July, says official China has authorised emergency usage of COVID-19 vaccines developed by some select domestic companies, a Chinese health official has said. An emergency use authorisation, which is based on Chinese vaccine management law, allows unapproved vaccine candidates to be used among people who are at high risk of getting infected on a limited period. "We've drawn up a series of plan packages, including medical consent forms, side-effects monitoring plans, rescuing plans, compensation plans, to make sure that the emergency use is well regulated and monitored," Zheng Zhongwei, head of China's coronavirus vaccine development task force, told state-run CCTV on Saturday. One month has passed since China officially launched the urgent use of COVID-19 vaccines on 22 July, while the vaccines were going through clinical trials, Zheng said. Recipients who got their first dose since then revealed they had few adverse reactions and none reported a fever. PTI 21:54 (IST) Coronavirus in Jharkhand LATEST Updates Jharkhand CM orders probe after photo of COVID-19 positive liquor drinking alcohol goes surfaces Jharkhand Chief Minister Hemant Soren on Sunday orderedan investigation after a photo purportedly showing a COVID-19 positive prisoner drinking alcohol inside a hospital ward in Dhanbad went viral. One person tweeted the photo to the chief minister and he retweeted it directing Dhanbad Deputy Commissioner Umashankar Singh to probe the matter and take action against those who were responsible for the irregularity. Singh said that the sub-divisional magistrate and the sub-divisional police officer concerned would carry out the investigation. "The chief minister has been informed of the progress of the probe," he said. The man in the viral photo is seen pouring liquor in a glass from a bottle while sitting on a hospital bed while food items served in aluminium foil containers are in front of him. A handcuff is also seen dangling from his right wrist. Katras police station officer-in-charge Ras Bihari Lal identified the man as 30-year-old Shantu Gupta, who was arrested on the charges of extortion on Thursday and was forwarded to jail. As he tested positive for coronavirus infection, the police admitted him to the central hospital of Bharat Coking Coal Limited (BCCL), which was converted to a dedicated COVID19 facility, on Friday. PTI 21:32 (IST) Coronavirus in India LATEST Updates Over 4,000 students go on hunger strike, demand exams be postponed The chorus for postponing various examinations, including NEET and JEE, grew louder on Sunday with over 4,000 students observing a day-long hunger strike to press for the demand in view of rising COVID-19 cases. The protest came on a day Congress leader Rahul Gandhi said the government must listen to the 'mann ki baat' of students and arrive at "an acceptable solution" and his party demanded that the National Eligibility cum Entrance Test (NEET) and the Joint Entrance Examination (JEE) be deferred. Read full report here 21:09 (IST) Coronavirus in Gujarat LATEST Updates Ahmedabad's case count up by 177 to 30,197 The number of COVID-19 cases in Ahmedabad district rose by 177 to 30,197 on Sunday, the Gujarat health department said. With five more fatalities, all from the city, the toll reached 1,685, it said. This is the fourth day in a row that Ahmedabad has been reporting more than 150 cases in a day. A total of 172 patients were discharged in the day, taking the number of recoveries to 25,104. Of the 177 cases, 153 infections were reported from Ahmedabad city while 24 cases were reported from rural parts of the district, the health department said. PTI 20:52 (IST) Coronavirus in Gujarat LATEST Updates Gujarat registers 1,101 new cases, 14 deaths With the addition of 1,101 new coronavirus positive cases on Sunday, Gujarat's COVID-19 count climbed to 86,779, the state health department said. The toll in the state reached 2,897 as 14 patients succumbed to the infection during the day, it said. As 972 patients were discharged from various hospitals on Sunday, the total number of recovered cases in the state rose to 69,229, the department said in a release. The state has now achieved the recovery rate of 80 per cent, it said adding that the number of active cases stood at 14,653. PTI 20:35 (IST) Coronavirus in Assam LATEST Updates Three senior Assam Police officers test positive Three senior Assam Police officers, including two Superintendents of Police, have tested positive for COVID-19 on Sunday, health officials said. Tinsukia SP Shiladitya Chetia and his Kokrajhar counterpart Rakesh Roushan have tested positive for the infection, they said. Tinsukia's Additional Superintendent of Police Ripunjoy Kakoti and Roushan's wife were also afflicted with the disease, the officials said. Chetia and Kakoti were suffering from fever and cough and their swab samples were tested. Roushan and his wife tested positive for the infection during raping antigen tests and were advised home isolation, they said. Dhubri Superintendent of Police Anand Mishra hadtested positive for COVID-19 last week. A total of 3,310 Assam Police personnel, including Director General of Police Bhaskar Jyoti Mahanta, have tested positive for the infection till date. Eleven police personnel have died, while 2,698 have recovered and 601 are undergoing treatment, officials said. PTI 20:22 (IST) Coronavirus in Maharashtra LATEST Updates Maharashtra reports 10,441 new cases, 258 deaths As many as 10,441 new coronavirus cases and 258 deaths were recorded in Maharashtra today, reports ANI quoting the state health department. The total number of caseshas climbed to 6,82,383 including 4,88,271 recoveries and 1,71,542 active cases, it said. 19:54 (IST) Coronavirus in Assam LATEST Updates Assam health minister launches first sero survey The first serological survey in Assam was launched in Guwahati by the Minister of state for Health and Family Welfare Pijush Hazarika on Sunday to assess whether people surveyed have developed immunity to novel coronavirus. A serological survey involves testing of the blood serum of individuals to check for the prevalence of antibodies against an infection. The survey titled 'A.A.S.H.A Assessment of Anti- SARSCoV2 Seroprevalence in Habitants of Assam: a populationbased cross sectional study' is an initiative of an NGO in partnership with a diagnostics solutions provider. "The need of the hour today is a seroprevalence study that would identify the proportion of people carrying antibodies against this virus," the minister said. 19:14 (IST) Coronavirus in Delhi LATEST Updates Delhi reports highest single-day spike in August Delhi recorded 1,450 fresh coronavirus cases on Sunday, the highest single-day spike in August, taking the infection tally to over 1.61 lakh, while the death toll mounted to 4,300. Sixteen fresh fatalities were recorded in the last 24 hours, officials said. Sunday's spike in fresh cases surpassed Saturday's increase of 1,412 cases, authorities said. The total number of cases stood at 1,61,466. The bulletin said that the number of active cases stood at 11,778, while 1,45,388 patients have either recovered, been discharged or migrated out. PTI 19:09 (IST) Coronavirus in Tamil Nadu LATEST Updates Tamil Nadu reports 5,975 new cases, 97 deaths Tamil Nadu reported 5,975 new COVID-19 cases, 6,047 recoveries and 97 deaths today, taking total cases to 3,79,385 including 3,19,327 discharges and 6,517 deaths. Number of active cases stands at 53,541, reports ANI quoting the state health department. 18:16 (IST) Coronavirus in Delhi LATEST Updates Delhi govt has requested Centre to allow resumption of Metro, says CM "We have requested Centre to allow re-opening of Delhi Metro in a phased manner, on a trial basis, as the COVID-19 situation in Delhi is under control now. I hope the Centre will take a decision soon," ANI quotes Delhi Chief Minister Arvind Kejriwal as saying. 17:56 (IST) Coronavirus in Delhi LATEST Updates COVID-19 situation in Delhi under control, says Kejriwal Delhi Chief Minister Arvind Kejriwal said that the COVID-19 situation in Delhi was under control, adding that it is "perhaps the only city" in the country where a lockdown was not re-imposed. "I am happy that with the help of everyone, the COVID-19 situation in the National Capital is under control now. The way Delhi has been dealing with COVID-19 situation is being discussed in the country as well as across the world," he said. We imposed lockdown in Delhi only once, and then gradually resumed work across fields from June 1 onwards. Probably, Delhi is the only city where lockdown hasn't been imposed again, as we understand work & COVID management can go hand-in-hand: Delhi Chief Minister Arvind Kejriwal pic.twitter.com/VWktQbCwxp — ANI (@ANI) August 23, 2020 17:38 (IST) Coronavirus in India LATEST Updates India could get COVID-19 vaccine by year-end if everything goes well: Harsh Vardhan Union Health Minister Dr Harsh Vardhan has said that if everything goes well, India would get a vaccine against the novel coronavirus by the end of this year. Three COVID-19 vaccine candidates, including two indigenous ones, are in different phases of development in India. The phase-one human clinical trials of the two indigenous COVID-19 vaccine candidates, one developed by Bharat Biotech in collaboration with ICMR and the other by Zydus Cadila Ltd, have been completed and the trials have moved to phase-two, ICMR Director General Dr Balram Bhargava had said recently. The Serum Institute of India, which has partnered with AstraZeneca for manufacturing the COVID-19 vaccine candidate developed by the University of Oxford has been permitted for conducting its phase two and three human clinical trials in India. It is likely to start the trials next week. कब तक आएगी #कोरोना की #vaccine ? पत्रकारों के इस सवाल पर मैंने उम्मीद जताई कि अगर सब कुछ ठीक रहा तो भारत इस साल के आखिर तक #coronavaccine हासिल कर लेगा। @MoHFW_INDIA @CSIR_IND @NDRFHQ pic.twitter.com/zqAxftKUdt — Dr Harsh Vardhan (@drharshvardhan) August 22, 2020 17:21 (IST) Coronavirus in Madhya Pradesh LATEST Updates Madhya Pradesh health minister says he tested COVID-19 positive Madhya Pradesh Health Minister Prabhuram Choudhary on Sunday said he has tested coronavirus positive. "My COVID-19 test report came out positive. I request those who had come in my contact to undergo a coronavirus test. Those in close contact should quarantine themselves," he tweeted. "With your prayers and blessings, I will return amidst you soon to serve the people," he said. Choudhary is the seventh minister in Madhya Pradesh, besides Chief Minister Shivraj Singh Chouhan, to test positive for the infection. In the last week of July, CM Chouhan had tested positive and recovered after treatment. PTI मेरी कोविड की रिपोर्ट टेस्ट के बाद पॉजि़टिव आई है।मेरा सभी से निवेदन है जो भी मेरे संपर्क में आए हैं, वह कोरोना टेस्ट करवा लें। मेरे निकट संपर्क वाले लोग क्वारनटीन में चले जाएं।आप सभी की प्रार्थना एवं आशीर्वाद से जल्द आप सभी के बीच उपस्थित होकर फिर जन सेवा के कार्यों में लगेंगे। — Dr. Prabhuram Choudhary (@DrPRChoudhary) August 23, 2020 17:06 (IST) Coronavirus in Uttar Pradesh LATEST Updates COVID-19 toll in Uttar Pradesh climbs to 2,926 Fifty-nine people succumbed to COVID-19 in Uttar Pradesh on Sunday, raising the toll due to the disease to 2,926 in the state, Additional Chief Secretary Amit Mohan Prasad said. Briefing reporters, the official said the case fatality rate stands at 1.56 percent. As many as 5,325 fresh coronavirus cases were reported in the state, taking the state-wide tally to 1,87,781, he said. So far, 1,35,613 COVID-19 patients have been discharged after recovering from the disease with the recovery rate at 72.21 percent, he further said. The count of active cases in the state stands at 49,242. The senior official said 1.3 lakh samples were tested in UP on Saturday. PTI 16:33 (IST) Coronavirus in India LATEST Updates Recovery rate nears 75%, says health ministry A steadily increasing number of recoveries has pushed India's recovery rate to nearly 75 percent, said the Union health ministry. With 57,989 COVID-19 patients recuperating in the last 24 hours, the total number of recoveries has reached 22,80,566. The total recoveries in the country now exceed the total active cases (7,07,668) by nearly 16 lakhs (1,572,898), it said in a statement. Active cases now comprise 23.24 percent of the country's total case load, it said. "This has also resulted in a gradually falling mortality rate. Currently at 1.86 percent, India's case fatality rate (CFR) is one of the lowest globally," the ministry said. The ministry said the average daily number of recoveries is on a "constant upward move" from 15,018 between July 1 and 7 to 60,557 between August 13 and 19. India’s total recoveries now exceed the total active cases (7,07,668) by nearly 16 lakhs (1,572,898): Ministry of Health https://t.co/upgE9GQ4YF — ANI (@ANI) August 23, 2020 16:12 (IST) Coronavirus in India LATEST Updates India has conducted around 3,52 crore COVID-19 tests so far, says health ministry Testing over eight lakh samples for six days in a row, India's total COVID-19 tests have touched 3.52 crore, while the average daily positivity rate has come down from 9.67 per cent during August 3-9 to 7.67 pc over the last week, the Centre said on Sunday. So far, 3,52,92,220 samples have been tested for detection of COVID-19 with 8,01,147 being tested on Saturday. The steep rise in testing is a result of effective implementation of the aggressive testing strategy of the Centre through a focussed and graded approach, the ministry said. "The rising average daily tests during the past three weeks present a strong depiction of the progress made in the enhancement of COVID-19 tests across the country. The rise in daily testing has been followed by a decrease in the average daily positivity rate," the health ministry highlighted. Keeping a sharp focus on the 'test, track and treat' policy, tests per million population have seen a boost, touching 25,574 as on date, it further stated. 15:43 (IST) Coronavirus in Puducherry LATEST Updates No e-pass required to travel to and from Puducherry E-passes are not required to travel to and from Puducherry, announced the Union Territory administration today, reports ANI. 15:18 (IST) Coronavirus in Singapore LATEST Updates New COVID-19 cluster reported at Singapore's biggest dormitory A new COVID-19 cluster has been reported in Singapore's biggest dormitory housing foreign workers, including Indian nationals, about a month after it was declared to be fully cleared of the coronavirus. Two of the new COVID-19 cases reported in Singapore on Saturday were linked to 55 previous cases to form a new cluster at Sungei Tengah Lodge dormitory at 500 Old Choa Chu Kang Road, the Ministry of Health (MOH) said. The cluster at Sungei Tengah Lodge was among the largest in Singapore before the dormitory was declared cleared of COVID-19 by the Ministry of Manpower (MOM) on Jul 21, the Channel News Asia reported. 15:01 (IST) Coronavirus in India LATEST Updates RTI finds 1.78 crore rail tickets cancelled in five months due to COVID-19 The Railways has cancelled more than 1.78 crore tickets since March this year due to the coronavirus pandemic and refunded an amount to the tune of Rs 2,727 crore, a RTI has found. The RTI has found that the Railways, which had suspended its passenger train services since 25 March, cancelled 1,78,70,644 tickets. PTI has earlier reported how perhaps for the first time the Railways has refunded more than it has earned from ticket bookings, registering a negative passenger segment revenue of Rs 1,066 crore in the COVID-19-hit first quarter of 2020-21. 14:35 (IST) Coronavirus in Gujarat LATEST Updates Homeopathic drug given to half of Gujarat population since March The Gujarat health department has said it distributed homeopathic drug Arsenicum Album-30 to more than half of the state's population as prophylaxis since March after the outbreak of COVID-19, reports PTI. In its presentation made before the World Health Organisation on August 20 on Gujarat's COVID-19 prevention strategy, the health department said it distributed Arsenicum Album-30 to 3.48 crore people, which is more than half of the state's population of 6.6 crore. There is no scientific evidence that the drug works against COVID-19, a fact stressed not only by medical scientists but by some homeopathic practitioners themselves. 13:51 (IST) Coronavirus in India LATEST Updates Media reports over availability of COVID-19 vaccine are false, says Serum Institute of India Serum Institute of India clarified on Sunday that the current claims over COVISHIELD's availability, in the media are completely false and conjectural. "Presently, government has granted us permission to only manufacture the vaccine and stockpile it for future use." the company said, reports ANI. "COVISHIELD will be commercialized once trials are proven successful & requisite regulatory approvals are in place. Phase-3 trials for Oxford-AstraZeneca vaccine are underway. Only once vaccine is proven immunogenic & efficacious,SII will confirm its availability officially," the company said. A Business Today report had said that India's first Covid vaccine-Serum Institute's 'Covishield'- will be commercialised in 73 days. 13:43 (IST) Coronavirus Outbreak LATEST Updates Children aged 12 and older should wear masks, says WHO Children aged 12 and older should wear masks like adults while those aged 6-11 should wear them on a “risk-based approach”, the World Health Organisation has said, reports moneycontrol. Risk-based approach includes considerations such as intensity of transmission in the area, the child's ability to use masks, access to masks, adequate adult supervision, potential impact on learning and psycho-social development and interactions with people at high risk of developing serious illness, the organisation said in a United Nations Children's Fund (UNICEF) document uploaded on August 21. 13:13 (IST) Coronavirus in Odisha LATEST Updates Odisha reports record 2,993 COVID-19 cases, 10 more deaths Odisha on Sunday registered its highest single-day spike of 2,993 COVID-19 cases and 10 more deaths due to the infection. With this, the state's COVID-19 death toll has mounted to 409 and the infection tally reached 78,530, a health official said. Fifty-three other coronavirus patients have also died, but the cause of their deaths was attributed to some other reasons. Of the new 2,993 cases, 1,879 were reported from different quarantine centres, while the remaining 1,114 were detected during contact tracing, he said. The state had last reported its highest single-day surge of 2,924 cases on 15 August. 12:57 (IST) Coronavirus in India LATEST Updates No change in Pranab Mukherjee's health, says hospital There is no change in the health of former President Pranab Mukherjee and he continues to remain on ventilator support, the Army''s Research and Referral hospital told PTI on Sunday. Doctors attending on the 84-year-old Mukherjee said his vital parameters are stable. Mukherjee was admitted to the hospital in Delhi Cantonment on 10 August and was operated for removal of a clot in the brain. He had also tested positive for COVID-19. 12:51 (IST) Coronavirus in India LATEST Updates Prakash Javadekar announces SOPs for resuming film, TV shooting According to Hindustan Times, Union information and broadcasting minister Prakash Javadekar on Sunday said film and television programme production can be resumed with all the necessary health protocols in place amid Covid-19 pandemic. After consultation with the home ministry and the health ministry, a standard operating procedure (SOP) has been firmed up, he said. According to the SOP, the actors facing the camera will be exempt from wearing masks. And crew members will have to adhere to the guidelines of the health ministry, reports NDTV. Read full report here 12:48 (IST) Coronavirus in Puducherry LATEST Updates 412 new COVID-19 cases push total to 10,522 in Puducherry The COVID-19 tally in the union territory rose to 10,522 and the toll mounted to 159 with the addition of 412 fresh cases and eight deaths, the Health Department said on Sunday. There were 3,706 active cases after the discharge of 350 patients in the last 24 hours ending at 10 AM. The cumulative recoveries stood at 6,657, Director of Health and Family Welfare S Mohan Kumar said in a release here. A total of 1,282 samples were tested during the period. 12:37 (IST) Coronavirus Outbreak Latest Updates Experts flag risks in India's use of rapid tests for virus In June, India began using cheaper, faster but less accurate tests to scale up testing for the coronavirus — a strategy that the United States is now considering. But India’s experience also highlights the inherent pitfalls of relying too heavily on antigen tests, at the expense of more accurate tests. The danger is that the tests may falsely clear many who are infected with COVID-19, contributing to new spread of the virus in hard-hit areas. Rapid test results can be backstopped with more accurate laboratory tests, but these are slower and expensive. Experts also warn that since the two types of tests vary in accuracy, they need to be interpreted separately to properly assess the spread of infection -- something India isn’t doing. 12:22 (IST) Coronavirus in Telangana Latest Updates 2,384 new cases in Telangana The total number of coronavirus cases in Telangana rose to 1,04,249 after 2,384 new infections were reported on Saturday. The total number of cases includes 22,908 active cases, 80,586 recoveries and 755 deaths. 11:44 (IST) Coronavirus in Uttar Pradesh LATEST Updates Three COVID-19 patients untraceable in UP's Muzaffarnagar Three people who tested COVID-19 positive in Uttar Pradesh's Muzaffarnagar district cannot be traced as they provided fake information and phone numbers during sample collection, officials said on Sunday. Two of them claimed to be staffers of a hospital here, while the third person had given his address as Saket Colony, they said. Health teams went to Saket Colony on Friday and to the hospital mentioned by the other two persons on Saturday to take them for treatment at a medical facility, the officials said. It was found that they had provided fake information, Chief Medical Officer Dr Praveen Chopda said. 11:37 (IST) Coronavirus in Rajasthan LATEST Updates Rajasthan reports 697 new cases, 6 deaths today Rajasthan reports 697 new COVID-19 cases and 6 deaths today, taking the total cases to 69,961 including 950 deaths, 54,252 recoveries and 14,759 active cases Rajasthan reports 697 new #COVID19 cases and 6 deaths today, taking the total cases to 69,961 including 950 deaths, 54,252 recoveries and 14,759 active cases: State Health Department pic.twitter.com/gr4k8lCXqK — ANI (@ANI) August 23, 2020 11:35 (IST) Coronavirus in Assam LATEST Updates Weekend lockdown being observed in Guwahati today Assam: Weekend lockdown being observed in Guwahati to control the spread of #COVID19. pic.twitter.com/yhEPWKlCvq — ANI (@ANI) August 23, 2020 11:02 (IST) Coronavirus in Maharashtra LATEST Updates Thane district reports 1,284 new COVID-19 cases, 26 deaths The number of COVID-19 cases in Maharashtra's Thane district has gone up to 1,13,884 with 1,284 more people testing positive for the disease, a health official told PTI on Sunday. The fatality count in the district has reached 3,240 as 26 more people succumbed to the viral infection on Saturday, he said. 10:33 (IST) Coronavirus in India LATEST Updates India's COVID-19 recovery rate rises to 74.9% India's COVID-19 tally sprinted past the 30-lakh mark, just 16 days after it crossed 20 lakh, while 22,80,566 people have recuperated in the country so far pushing the recovery rate to 74.90 per cent, according to the Union Health Ministry data. With a single-day spike of 69,239 infections, the country's COVID-19 caseload mounted to 30,44,940, while the death toll climbed to 56,706 with 912 fatalities being reported in a span of 24-hours, the data updated at 8 am showed.The COVID-19 case fatality rate has declined to 1.86 percent. There are 7,07,668 active cases of coronavirus infection in the country which comprises 23.24 per cent of the total caseload, the data stated. 10:24 (IST) Coronavirus in India LATEST Updates ICMR says over 8.1 lakh samples tested yesterday The Indian Council of Medical Research (ICMR) has said that 3,52,92,220 samples were tested for COVID-19 in the country till yesterday (August 22). Of these, 8,01,147 were tested yesterday. 09:55 (IST) Coronavirus in Uttar Pradesh LATEST Updates 23 people test positive for COVID-19 in UP's Shamli district The number of active COVID-19 cases in Uttar Pradesh's Shamli district has increased to 150 with 23 people testing positive for the infection, officials told PTI on Sunday. The district also reported a death from the novel coronavirus and the toll now stands at 15, they said. "Twenty-three people have tested positive for COVID-19. Their reports were received on Saturday evening. On the same day, six patients recovered," District Magistrate Jasjit Kaur said. The officials said that a woman from Thanabhawan town died at a hospital on Saturday, taking the death toll to 15 in the district. 09:35 (IST) Coronavirus in India LATEST Updates India's COVID-19 total crosses 30 lakh with over 56,000 deaths India’s coronavirus tally on Sunday breached the 30-lakh mark after the country reported 69,239 new cases in the last 24 hours. The country’s toll rose by 912 to 56,706. Of the overall tally of 30,44,940, India now has 7,07,668 active cases while more than 22 lakh people have recovered from the infection 09:07 (IST) Coronavirus in Jharkhand LATEST Updates Jharkhand Agriculture Minister Badal Patralekh tests COVID-19 positive सभी राज्यवासियों को जोहार, मैंने कल अपना कोरोना जांच कराया, जिसकी रिपोर्ट देर रात्रि पॉजिटिव आई हैं।विगत कुछ दिनों में जो भी लोग मेरे संपर्क में आये हैं उनसे विनम्र अनुरोध है कि अपनी जांच करा लें। आप सभी से अनुरोध हैं घर पर रहे सुरक्षित रहें। — Badal (बादल) (@Badal_Patralekh) August 23, 2020 09:05 (IST) Coronavirus in Uttar Pradesh LATEST Updates Weekend lockdown being observed in Prayagraj today Weekend lockdown being observed in Prayagraj, to curb the spread of #COVID19 pic.twitter.com/fjj4uHqCXG — ANI UP (@ANINewsUP) August 23, 2020 08:55 (IST) Coronavirus in Assam LATEST Updates Toll due to COVID-19 rises to 234 in Assam The toll in Assam due to the pandemic rose to 234 with seven more succumbing to it, Health and Family Welfare Minister Himanta Biswa Sarma said on Saturday. The seven deceased are from Jorhat, Dibrugarh, Cachar, Kamrup, Sonitpur and Kamrup Metropolitan districts, Sarma tweeted. The persons affected included a 77-year-old from Kamrup Metropolitan district, which primarily cinsists of the Guwahati city. The others are a 77-year-old and a 60-year old from Dibrugarh district the fourth one is a 46-year old man from Jorhat, Sarma said. Three more persons aged 63 years, 55 years and 60 years of age lost their lives in Cachar, Kamrup and Sonitpur districts respectively, he added. #AssamPlasmaHero ~ Aug 21 5. Pratim Talukdar (38), Ganakpara, Azara/ GMCH 6. Surajit Kalita (36), Pathsala, Barpeta/ GMCH 7. Prafulla Deka (53), Guwahati/ MMCH 8. Dr Biswajit Haloi (34)/Narayan Hospital Gratitude 🙏 pic.twitter.com/oAozWZRbGS — Himanta Biswa Sarma (@himantabiswa) August 22, 2020 08:18 (IST) Coronavirus in Indian LATEST Updates Sharp rise in recoveries and recovery rate key to India's success against COVID-19, says Centre #CoronaVirusUpdates The key to India's success in its fight against #COVID19: consistently and sharply rising recoveries and Recovery Rate.@PMOIndia @drharshvardhan @AshwiniKChoubey @PIB_India @DDNewslive @airnewsalerts @COVIDNewsByMIB @ICMRDELHI @mygovindia @CovidIndiaSeva pic.twitter.com/NRPPMB1xUs — Ministry of Health (@MoHFW_INDIA) August 23, 2020 07:49 (IST) Coronavirus in Italy LATEST Updates Italy sees over 1,000 new coronavirus cases in a day Italy recorded 1,071 new cases of the novel coronavirus in the last 24 hours, the worst daily number since lockdown was lifted in May, the health ministry reported on Saturday. The ministry's figures showed that three people died from disease caused by the virus, bringing total deaths to 35,430 in Italy since the pandemic began. Total infections number 258,136. 07:40 (IST) Coronavirus in Odisha LATEST Updates Odisha's COVID-19 total climbs up to over 75,000 cases Odisha's COVID-19 tally rose to 75,537 on Saturday with the detection of 2,819 fresh infections, while nine more fatalities pushed its coronavirus death toll to 399, a health official told PTI. Three fresh fatalities were registered in Cuttack, two in Sundargarh and one each in Bolangir, Ganjam, Malkangiri and Rayagada districts, he said. The fresh COVID-19 cases were reported from 29 of the 30 districts of the state. 07:36 (IST) Coronavirus LATEST Updates World virus deaths top 8,00,000 as nations ramp up measures The global toll from the new coronavirus has surpassed 800,000, according to an AFP count on Saturday, with numerous countries ramping up restrictions in an effort to battle an eruption of new cases. Western Europe, particularly Spain, Italy Germany and France, has been enduring infection levels not seen in many months, sparking fears of a fully-fledged second wave. And in Asia, South Korea, which had largely brought the virus under control, became the latest country to announce it would boost restrictions to try to stem a new outbreak. Across the world, the number of deaths has doubled to just over 800,000 since June 6, with 100,000 fatalities in the last 17 days alone, while more than 23 million cases have been registered. Coronavirus LATEST Updates: China has authorised emergency usage of COVID-19 vaccines developed by some select domestic companies, a Chinese health official has said. The first serological survey in Assam was launched by the Minister of state for Health and Family Welfare Pijush Hazarika on Sunday to assess whether people surveyed have developed immunity to novel coronavirus. Children aged 12 and older should wear masks like adults while those aged 6-11 should wear them on a 'risk-based approach', the World Health Organisation has said According to the SOP, the actors facing the camera will be exempt from wearing masks. And crew members will have to adhere to the guidelines of the health ministry Of the overall tally of 30,44,940, India now has 7,07,668 active cases while more than 22 lakh people have recovered from the infection India's coronavirus case count raced past 30 lakh on Saturday, showed an unofficial tally based on information provided by staes and Union territories, while the toll rose to 56,762 and recoveries climbed to 22,71,054. India is the third-worst affected country by the viral infection, said news agency PTI, which compiled the data. The virus has claimed over eight lakh lives globally. However, according to data released by Union Ministry of Health and Family Welfare on Saturday morning, the overall case count in India has climbed to 29,75,701 with the country recording its highest single-day spike of 69,874 new coronavirus cases. The toll climbed to 55,794 with 945 fatalities being reported in a span of 24 hours, the data updated at 8 am showed. But the number of recoveries also surged to 22,22,577 pushing the recovery rate to 74.69 percent on Saturday while the fatality rate dipped to 1.87 percent, said the ministry. India on Saturday also crossed the significant milestone of having conducted over 10 lakh tests in a day for the detection of the novel coronavirus, with more than 3.44 crore such tests conducted so far. The COVID-19 case count in Telangana crossed the one-lakh mark with 2,474 new cases while the toll touched 744. In Jharkhand, Chief Minister Hemant Soren said his father, veteran Jharkhand Mukti Morcha leader Shibu Soren, and his mother Roopi, tested positive for the viral infection and are placed in home quarantine. Recoveries exceed active cases by 15 lakh, says health ministry The home ministry, in its morning update, said that there are 6,97,330 active cases of coronavirus infection in the country, comprising 23.43 percent of the total caseload in the country. While the country's COVID-19 case count has surged to 29.75 lakh, the total number of recoveries has surged to 22,22,577 and exceed active cases by over 15 lakh as on date, it said. Union Health Minister Harsh Vardhan, at the inauguration of a make-shift NDRF hospital in Ghaziabad, said that India has the "best" COVID-19 recovery rate, which is improving every day, and the "lowest" mortality rate in the world. Taking a potshot at government critics, Vardhan said "many intelligent people, scientists and naysayers" had estimated that India, with a population of about 135 crore, will see 30 crore COVID-19 cases and about 50-60 lakh people will die by July-August, and the country's healthcare system was "incapable" to combat the disease. "However, I am happy to say that in the eighth month of the battle, India has the best recovery rate of 75 percent and against an estimate of 30 crore affected we have not even reached 30 lakh cases." "In fact, 22 lakh patients have recovered and gone home and another seven lakh are going to be cured very soon," he said. The minister said these successes were achieved due to the "coordinated" efforts with the participation of everyone — the government and the people. Centre asks states to ensure unrestricted movement of goods, people Meanwhile, the Centre asked all states to ensure that there are no restrictions on inter-state and intra-state movement of persons and goods during the ongoing unlocking process. In a communication to chief secretaries of all states and Union Territories, Union Home Secretary Ajay Bhalla said there were reports that local level restrictions on movement were being imposed by various districts and states. Drawing attention to the Unlock-3 guidelines, Bhalla said such restrictions are creating problems in inter-state movement of goods and services and are impacting supply chains, resulting in disruption of economic activity and employment. The unlock guidelines clearly state that there shall be no restrictions on inter-state and intra-state movement of persons and goods, he said in the letter. The guidelines also stated that no separate permission, approval or e-permit will be required for movement of persons and goods for cross land border trade under treaties with neighbouring countries. The home secretary said the restrictions amount to violation of the guidelines issued by Ministry of Home Affairs under provisions of Disaster Management Act, 2005. JMM chief Shibu Soren tests positive Rajya Sabha MP and Jharkhand Mukti Morcha (JMM) president Shibu Soren and wife Roopi have tested positive for COVID-19, his son and Jharkhand chief minister Hemant Soren said. Taking to Twitter, the chief minister said "respected father Dishom Guru ji" and mother were diagnosed with the disease on Friday night, and they are undergoing home quarantine. The 76-year-old president of the ruling JMM in the state is revered as 'guruji' (master) by his followers. कल रात आदरणीय बाबा दिशोम गुरु जी और माँ की कोरोना संक्रमण रिपोर्ट पॉजिटिव आयी। वे दोनों होम आइसोलेशन में हैं और स्वास्थ्य लाभ ले रहे हैं। देश और झारखण्डवासियों की दुआओं के साथ जल्द ही आदरणीय बाबा और माँ हम सभी के बीच होंगे। — Hemant Soren (घर में रहें - सुरक्षित रहें) (@HemantSorenJMM) August 22, 2020 // // ]]> "With the blessings of the people of Jharkhand and the entire country, they will soon be among us, the CM tweeted. Seven other members of the JMM chief's household have also tested positive for the viral infection, reported news agency PTI quoting official sources. The chief minister, who lives at his official residence, close to the JMM chief's government bungalow, will undertake the test on Monday -- third time in two months. Earlier, Hemant had taken the test on two separate occasions — first time after coming in contact with infected Cabinet colleague Mithilesh Thakur, and the second time after 17 employees at his office were diagnosed with the disease. On Tuesday, state health minister Banna Gupta was diagnosed with the disease. Punjab minister tests positive In Punjab, Chief Minister Amarinder Singh said that Cooperation and Jails Minister Sukhjinder Singh Randhawa has tested positive for COVID-19. "I wish him a speedy recovery and look forward to him joining us at work soon," said Singh. My Cabinet colleague and Cooperation & Jails Minister Sukhjinder Singh Randhawa has tested positive for #Covid19. I wish him a speedy recovery and look forward to him joining us at work soon. — Capt.Amarinder Singh (@capt_amarinder) August 22, 2020 // // ]]> Former Chief Minister Parkash Singh Badal's residence in Muktsar district was declared as a micro containment zone after five security personnel posted there tested positive, a health official told PTI. Punjab on Saturday reported 45 deaths and 1,320 fresh infections, pushing the death count to 1,036 and total infections to 40,643. Telangana's case count crosses one lakh Telangana's overall case count rose to 1,01,865 as 2,474 new cases were added. With seven more people succumbing to the virus, the toll in the state mounted to 744. However, the state's recovery rate at 77.29 percent was higher than the country's recovery rate of 74.69 percent. Maharashtra, Andhra Pradesh, Gujarat and West Bengal were among the other states which added high numbers to their case tallies. While Maharashtra reported 14,492 new cases and 297 deaths, Andhra Pradesh reported over 10,000 fresh infections. The overall count in the southern state climbed to 3,45,216 and the toll mounted to 3,189. Gujarat its highest single-day spike of 1,212 new COVID-19 cases, taking the total count of infections to 85,678, the state health department said. The number of fatalities rose by 14, including six in Surat, which is the highest in the state, to 2,883, it said. A total of 980 patients were discharged in the day, taking the number of recoveries to 68,257, the department said, adding that the recovery rate has reached 80 percent. With a record 3,232 new cases in a single day, West Bengal's caseload went up to 1,35,596. The toll reached 2,737 with 48 more people succumbing to the disease, said a bulletin issued by the state health department. With inputs from agencies

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