#Primary progressive Multiple Sclerosis

[caregiversherry]

Josh (my husband) started using a walker recently. Before that he was using a cane. Our 10 year anniversary was this past weekend and we had pictures taken in NYC in front of a horse and carriage. Josh posted a picture with his walker in it for the first time on Facebook and an acquaintance of his commented something that needs to be discussed. He said that Josh needs to stop selling himself short by using assistance to walk and that he’s stronger than that. This is not only ignorant but hurtful. No one knows what someone else is going through and not everyone with MS has the same level of symptoms. It is not safe for him personally to walk without assistance, such as a cane or walker at this point due to falls and extremely poor balance. I could definitely go on forever about MS awareness but in a nutshell, no two people are alike. Don’t tell someone who is trying to better their quality of life to stop selling themself short. In fact, maybe ask why they’re using it instead if you (clearly) don’t know.

[twwpress]

Weekly Press Briefing #93: March 31st - April 6th

Welcome back to the Weekly Press Briefing, where we bring you highlights from The West Wing fandom each week, including new fics, ongoing challenges, and more! This briefing covers everything posted from March 31 - April 6, 2024. Did we miss something? Let us know; you can find our contact info at the bottom of this briefing!

Challenges/Prompts:

There are no open challenges or events on our radar this week. Do you have a challenge or event you’d like us to promote or know of one we’re missing? Be sure to get in touch with us! Contact info is at the bottom of this briefing.

This Week in Canon:

Welcome back to This Week in Canon, where we revisit moments in The West Wing that occurred on these dates during the show’s run.

Season 1, Episode 18: Six Meetings Before Lunch aired on April 5, 2000.

Season 2, Episode 18: 17 People aired on April 4, 2001.

Season 3, Episode 17: Stirred aired on April 3, 2002.

Season 4, Episode 19: Angel Maintenance aired on April 2, 2003.

Season 5, Episode 18: Access aired on March 31, 2004.

Season 6, Episode 22: 2162 Votes aired on April 6, 2005.

Photos/Videos:

Here’s what was posted from March 31 – April 6:

Allison Janney posted a still from this week’s Palm Royale episode. 

Allison Janney posted a video of herself dancing on the set of Palm Royale, along with a shout out to her hairstylist. 

Janel Moloney posted a photo of the Fortnite-themed Durr Burgers she made for her sons. 

Josh Malina posted screenshots of his wedding gift to another Josh Malina. Josh Malina posted a photo of himself impersonating Bart Simpson. 

Peter James Smith posted photos from rehearsal for his upcoming play, Nora, which previews April 21. 

Rob Lowe posted a photo of his dogs looking at the ocean. 

Donna Moss Daily: March 31 | April 1 | April 2 | April 3 | April 4 | April 5 | April 6

Daily Josh Lyman: March 31 | April 1 | April 2 | April 3 | April 4 | April 5 | April 6

No Context BWhit: March 31 | April 1 | April 2 | April 3 | April 4 | April 5 | April 6 

@twwarchive: April 1 | April 2 | April 3 | April 4 | April 6

@twwgifs: April 2

Editors’ Choice: 

Here are a few fics based on or featuring points from episodes that had airdate anniversaries this week. Be sure to share your favorites with us, too!

Four Days by TheBreakfastGenie | Rated G | Josh Lyman & Toby Ziegler (No Pairings Listed) | Complete | After the president tells Josh he has multiple sclerosis, Toby is waiting in his office. Josh and Toby talk about re-election, loyalty, and a few other things. Five Minutes and the Future by glassessay | Rated T | Josh Lyman/Donna Moss | Complete | “I don’t want to be angry about it anymore,” he says. “I’m tired, Donna. I just want my best friend back.” “Sam’s in California,” she says. “Did you not hear the capital letters? Capital B capital F Best Friend, Donna, I’m talking little matching charms on our bracelets—" “I’m tired too,” she blurts out. “It’s been a long primary.” It’s less than an hour before what’s likely the last speech of the Santos campaign, and Josh has an apology he needs to make. all I need’s a whisper in a world that only shouts by Luppiters | Rated M | Danny Concannon/C.J. Cregg | In Progress | Drabbles and ficlets inspired by requests, prompts, and just about anything, written over the years. Mostly C.J./Danny, together and apart. The Jackal, a Brief History by aronos_zitro | Rated G | Andrea Wyatt/Toby Ziegler | Complete | Have you ever wondered how The Jackal became a "thing" for CJ and the staff? Here's a brief history of how we came to have this timeless scene from "Six Meetings Before Lunch" (S01E18). Oneshot.

Fics:

Presenting your weekly roundup of fics posted in the tag for The West Wing on Archive of Our Own. 

Josh/Donna

this is the wonder (that's keeping the stars apart) by joshatella (shuuuliet) | Rated T | Josh Lyman/Donna Moss | In Progress

The Theory of Entropy by Jane_3yr3 | Rated M | Josh Lyman/Donna Moss | Complete

A Year In the Life by Proportional Response | Not Rated | Josh Lyman/Donna Moss | In Progress

CJ/Toby

In Plain Sight by JediAnnieScrambler | Rated M | C. J. Cregg/Toby Ziegler | Complete

Other Pairings/Gen Fic

Sam Seaborn is Interviewed by Hackney123 | Rated G | No Pairings Listed | Complete

Regarding Jamie: Sound and Fury by mlea7675 | Rated G | Helen Santos/Matt Santos | In Progress

Allergies by shecouldnotcomeupwithaname | Rated G | C. J. Cregg/Kate Harper | Complete

i could be your (crush crush crush) by taliamytaliae | Rated T | Josh Lyman/Sam Seaborn | Complete

EAD2021: Fight for All by hellbells (NCIS crossover) | Rated T | Anthony DiNozzo/Sam Seaborn | In Progress

We had a deal by Labda | Not Rated | Abbey Bartlet/Jed Bartlet | In Progress

Helen Visits Wisconsin by Hackney123 | Not Rated | Donna Moss/Helen Santos | Complete

THE WEEKLY PRESS BRIEFING TEAM CAN BE REACHED VIA THE FOLLOWING METHODS:

Twitter: @twwpress Email: weeklypressbriefing@gmail.com

Feel free to let us know if we missed something, if you have an event you’d like us to promote, or if you have an item that you’d like included in the next briefing!

xx, What’s next?

[spacetimewithstuartgary]

NASA’s SpaceX CRS-30 MISSION

Cartilage repair, retinal gene therapies, neurological disease treatments, and technology testing on external platforms among investigations flying on NASA’s SpaceX CRS-30

The next resupply mission to the International Space Station (ISS) will carry more than 40 payloads sponsored by the ISS National Laboratory®, including in-space production applications projects, technology demonstrations, life science experiments, and student-led inquiries. These investigations, launching on SpaceX’s 30th Commercial Resupply Services (CRS) mission, funded by NASA, aim to improve life on Earth through space-based research and foster a sustainable economy in low Earth orbit (LEO).

Below highlights a sample of those payloads, and findings could lead to advances in technology for future spaceflight and the development of novel therapeutics for use both on Earth and in space.

Redwire Corporation is partnering with pharmaceutical company Eli Lilly & Company and Butler University for two investigations leveraging Redwire’s Pharmaceutical In-space Laboratory (PIL-BOX), a platform to crystallize organic molecules in microgravity. Results from this research could lead to improved therapeutics to treat an array of conditions. This research continues Eli Lilly’s space journey, as the company has launched a variety of investigations to the orbiting laboratory over the years for the benefit of patient care on Earth.

A collaboration between Boeing and CSIRO (an Australian government agency responsible for scientific research) will test the ability of a Multi-Resolution Scanner to create 3D maps of the space station. To do this, the project will use Astrobee, an autonomous free-flying robotic system on station. This scanner technology could be useful in future exploration efforts and in remote environments for manufacturing and maintenance tasks, such as identifying leaks or checking for damage to systems.

The National Stem Cell Foundation will continue to examine the mechanisms behind neuroinflammation, a common feature of neurodegenerative diseases. To carry out this study, the research team created 3D brain models derived from induced pluripotent stem cells of patients with Alzheimer’s and Parkinson’s diseases as well as primary progressive multiple sclerosis.

Airbus U.S. Space & Defense is launching an enhancement to the station’s Bartolomeo platform. Called ArgUS, the external mechanical platform has added capabilities for hosting payloads in LEO. Once ArgUS is installed, it will host multiple payloads on this mission, including SpaceTV-1, an optical video system designed to livestream high-definition views of Earth and the space station.

A project from the University of Connecticut will examine the feasibility of producing Janus base nanomaterials in microgravity that could help repair cartilage and reduce joint inflammation. Through this project, researchers aim to advance in-space manufacturing concepts for these materials, which could significantly improve patient care for orthopedic injuries and degenerative joint diseases like arthritis, as there is currently no way to repair damaged cartilage.

Additionally, two investigations flying on NASA’s SpaceX CRS-30 mission were selected through the Technology in Space Prize, funded by Boeing and the Center for the Advancement of Science in Space™ (CASIS™), manager of the ISS National Lab, as part of the MassChallenge startup accelerator program.

An investigation from biopharmaceutical company Oculogenex will use the space station to test a novel gene therapy to prevent and possibly even reverse vision loss from age-related macular degeneration (AMD). Findings will help advance the company’s therapeutic, which can potentially treat AMD-related symptoms in millions of Americans.

A project from biomedical startup Encapsulate aims to leverage the microgravity environment of the space station to validate an automated tumor-on-a-chip system that grows patient-derived cancer cells to test chemotherapy drugs. The company seeks to use precision diagnostics for personalized cancer treatments.

SpaceX’s Falcon 9 rocket will launch these investigations and more no earlier than Thursday, March 21, 2024, at 4:55 p.m. EDT from Space Launch Complex 40 at Cape Canaveral Space Force Station in Florida.

[scientificinquirer-blog]

DAILY DOSE: Saudi universities exposed for paying-off top scientists to steal some shine; Endangered Sumatran rhino born in captivity.

STEM CELL THERAPY FOR MS. A recent early-stage trial has shown promising results for a new stem cell therapy for multiple sclerosis (MS). In this trial, neural stem cells were injected into the brains of 15 patients with secondary progressive MS, a more advanced stage of the disease where few treatments are effective. The primary aim was to assess safety, and the results were encouraging,…

[darlingdollhousevn]

If it's not too much of a spoiler, what chronic neurological illness does Lowell have? (Unless it's already posted somewhere and I just didn't notice, in which case my bad)

The conditions he has themselves are not spoilers! Lowell's primary diagnoses are Mixed Connective Tissue Disease and Relapsing Remitting Multiple Sclerosis that is starting to progress more rapidly. He also suffers from gastroparesis, which makes it incredibly difficult for him to eat properly, a thyroid disorder, and he was just diagnosed with the beginning stages of rheumatoid arthritis at the onset of the game.

Lowell has been ill since he was a child, but he grew up in a neglectful household so he didn't recieve necessary medical care, and he both went to culinary school and now works as a commercial baker. He was essentially able to push past a lot of his symptoms to appear able bodied and has worked well past his limits for a long time, at massive detriment to his body- he's starting to feel the effects of his conditions acutely, and his ability to maintain his job and live a relatively normal life are declining rapidly.

I'm sparing the gorey details of how his conditions effect him in the two milder routes, but they will be playing a large part in the croquembouche route.

Lowell's feelings of losing control within his own body highly inform his character and his actions, and are drawn in large part by my own struggle with chronic and progressive disabilities- we don't share all of our diagnoses, but Lowell does have a few conditions that I myself suffer from.

[mommyandthesickness-blog]

INTRODUCTIONS ARE IN ORDER

Hey there! I’m Angie and this is a blog for pretty much things I’m into and about my life and living with chronic auto-immune illnesses.

- so, what are these chronic immune issues you have then? -

I never thought you’d ask!

1. Hashimotos Disease :

- hashimotos disease is a thyroid disorder. It’s where your thyroid fluctuates between over and under active!

- the interesting thing about the thyroid is that it is the house for several of your hormones. The main hormones it hold is your body’s metabolism. It also plays a role in controlling your heart, muscle and digestive function, brain development, and bone management.

- my experience with the beginnings of my thyroid issues. In the beginning I would fall asleep at random moments, have extreme outbursts emotionally, and weigh gain.

- no cure, managed medically

2. Type 1 Diabetes :

- type 1 diabetes is very different than type 2 diabetes. T1D (Type 1 diabetes) affects your pancreas and insulin production. With T1D your pancreas produces little to no insulin on its own. T2D you either don’t produce enough insulin or you are insulin resistant.

- T1D is usually diagnosed in adolescent years as T2D is usually diagnosed in your adult years.

- I was diagnosed with T1D when I was 16 years old. As time went on and my pancreas basically gave up on producing insulin to where I had to become dependent on an insulin pump. I am basically a cyborg because I have a robotic pancreas that gives me insulin all day long to keep my blood sugars within a normal range.

- no cure, managed medically

3. Multiple Sclerosis :

- multiple sclerosis is where your immune system decides the nerves on your brain are attacking and therefore your immune system attacks the nerves on your brain breaking down the myelin coating protecting the nerves causing so many shitty symptoms.

- because the immune system is attacking the myelin, it affects your entire body because the nerve damage disrupts the communication between your brain and your body.

- there are several different levels of disability when it comes to MS (multiple sclerosis):

> CIS : Clinically Isolated Syndrome

The first episode of MS caused by inflammation and damage to the myelin. CIS doesn’t meet the requirements for an MS diagnosis

> RRMS : Relapsing-Remitting MS

It generally follows a predictable pattern where symptoms worsen and then improve. You have relapsing periods of “flare ups” and then you have a period of remission (no symptoms). Remission can last days to decade depending on MS drug management

> SPMS : Secondary Progressive MS

SPMS is the progression of RRMS. It is much more aggressive. They may have small lapses of remission but the disease and damage is noticeable and continues on worsen

> PPMS : Primary Progressive MS

A very uncommon diagnoses of MS. It affects around 10% - 15% of people after the diagnosis of SPMS. It is a slow and steady progression of MS with no remission periods.

- my experience with MS caused issues with my vision first. My left eye was blurry and lights were really bright. It was called optic neuritis due to MS. As it progressed I had trouble walking and would have to use a cam for balance reasons due to falling.

-no cure, managed medically

Oof. That’s a lot of bullshit, huh?

Luck for me I can manage my auto-immune issues with medications, physical therapy, medical devices, and chemotherapy.

If you have any questions about any of my issues, feel free to reach out!

If you’re just like me, I would love to connect!

Now that you know more about me, I would love to know more about you! Especially if you made it this far in this long ass post!

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[spacetimewithstuartgary]

Astronauts from NASA's Expedition 71 to conduct research aboard space station

Studies of neurological organoids, plant growth, and shifts in body fluids are among the scientific investigations that NASA astronauts Matthew Dominick, Michael Barratt, Jeanette Epps, and Tracy C. Dyson will help support aboard the International Space Station as part of Expedition 71. The crew members are targeting launch to the space station in February and March.

Here are details on some of the work scheduled during this upcoming expedition aboard the microgravity laboratory.

Modeling neuroinflammation

Human Brain Organoid Models for Neurodegenerative Disease & Drug Discovery (HBOND) studies the mechanisms behind neuroinflammation, a common feature of neurodegenerative disorders. Researchers create organoids using patient-derived iPSCs (induced pluripotent stem cells) from patients who have Parkinson's disease and primary progressive multiple sclerosis.

The sixth space station organoid investigation, HBOND includes for the first time Alzheimer's iPSCs and testing of the effects of drugs in development to treat neuroinflammation. Results could help improve diagnostics, provide insights into the effects of aging, accelerate drug discovery, and identify therapeutic targets for patients suffering from neurodegenerative diseases. The organoid models also could provide a way to anticipate how extended spaceflight affects the brain and support development of countermeasures.

Protecting plants from spaceflight stressors

Plants can serve as a source of food and provide other life-support services on long-term missions to the moon and Mars. The Study on Plant Responses Against the Stresses of Microgravity and High Ultraviolet Radiation in Space (Plant UV-B) examines how stress from microgravity, UV radiation, and the combination of the two affect plants at the molecular, cellular, and whole organism levels. Results could increase understanding of plant growth in space and support improvements in plant cultivation technologies for future missions.

Reversing fluid shifts

Weightlessness causes fluids in the body to move toward the head, which can cause changes in eye structure and vision known as Spaceflight Associated Neuro-ocular Syndrome (SANS) along with other health problems. Mitigating Headward Fluid Shifts with Veno-constrictive Thigh Cuffs During Spaceflight (Thigh Cuff) examines whether thigh pressure cuffs could provide a simple way to counter this shift in body fluids and help protect astronauts from SANS and other issues on future missions to the moon and Mars. Thigh cuffs also could help treat or prevent problems for patients on Earth who have conditions that cause fluid accumulation in the head, such as long-term bedrest and diseases.

Incredible edible algae

Arthrospira-C (Art-C), an investigation from ESA (European Space Agency) analyzes how the cyanobacterium Limnospira responds to spaceflight conditions and whether it produces the same quantity and quality of oxygen and biomass in space as on Earth. These microalgae, also known as Spirulina, could be used to remove carbon dioxide exhaled by astronauts, which can become toxic in an enclosed spacecraft, and to produce oxygen and fresh food as part of life support systems on future missions.

Correct predictions of oxygen and biomass yields are crucial for design of life support systems using bioprocesses. Spirulina also has been shown to have radioprotective properties and eating it could help protect space travelers from cosmic radiation, as well as conserve healthy tissue in patients undergoing radiation treatment on Earth.

TOP IMAGE....Brain organoid cells from the previous investigation Cosmic Brain Organoids are made of cells from people with Parkinson’s Disease and primary progressive multiple sclerosis. Credit: New York Stem Cell Research Institute

LOWER IMAGE....This image shows the Plant Experiment Unit (PEU) hardware for the Plant UV-B investigation. Credit: NASA

[desmoinesnewsdesk]

Primary Progressive Multiple Sclerosis Treatment Market Size, Share, Trends, Growth And Forecast To 2032

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[thedaytimereport]

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