#Schwannomatosis

[king-ennui]

It's May again, and that means it's NF Awarness Month. If you can, take a little time to eductate yourself about the condition. Perhaps even donate to one of the NF charities such as Nerve Tumours UK or the Neurofibromatosis Network.

As someone with this condition, it would mean a lot to me if you helped spread some information. I'll make a more personal post about my experience living with the condition later.

💚💙

[neurofibromemetosis]

Is this a fibroma I feel underneath my skin or is nothing there and I'm just being paranoid?: An NF Autobiography

[aceoffangirls]

May is Neurofibromatosis (NF) awareness month

NF is a set of 3 complex genetic condition that causes benign tumours to grow on the body.

NF 1 is the most common effecting around 1 in 2500 (AU). It causes benign tumours known as neurofibromas, café-au-lait marks. These benign tumours can appear anywhere from the spinal cord, optic nerve, neck, arms, stomach etc. It can also cause learning disability’s. NF 1 extremely variable condition with some being able to live their life unaffected and others it could debilitating and in some cases life threatening.

NF 2 affects approximately 1 in every 25,000-40,000 people (AU). It is characterised by d by the development of tumours called vestibular schwannomas on the 8th cranial nerve. It can also lead to begin tumours on the brain and spinal cord.

Schwannomatosis is the rarest form of neurofibromatosis and has only recently been identified as a separate condition. It affects less than 1 in every 40,000 people and causes the development of tumours called schwannomas to form on nerves on the spine and other peripheral nerves.

I have NF1.

Information from

[smokesforharris]

Free online event for young adults with NF

[brookstonalmanac]

Holidays 5.22

Holidays

Abolition Day (Martinique)

Bălți Day (Moldova)

Bear Waking Day (Norway)

Buy A Musical Instrument Day

Canadian Immigrants' Day

Carpet Day (Turkmenistan)

Clover Day (French Republic)

Dia do Abraço (National Hugging Day; Brazil)

EMS Education Day

Ethernet Day

Ewokalypse

Find Your Soul Mate Day

Flag Adoption Day (Australia)

Goth Day

Growing Flavor in the Garden Day

Harvey Milk Day (California)

Heat Awareness Safety Day

International Being You Day

International Coco Mom Day

International Day For Biological Diversity (UN)

International Day of Syndrome 22q11

International Sherlock Holmes Day

Jumping Frog Jubilee Day (Angel's Camp, California)

Lee Rigby Memorial Day

Leiria Day (Portugal)

Loch Ness Monster Day

Manchester Arena Remembrance / 22 Angels Day (UK)

Mattie Stepanek Day (Rockville, Maryland)

Mr. Rogers' Neighborhood Day

National Boss Babes Day

National Coco Mom Day

National Curly Hair Day

National Day of First Nations Fishing Rights (Canada)

National Desert Storm Reservists Day

National Gout Awareness Day

National Heroes Day (Sri Lanka)

National Julie Day

National Maritime Day

National Psychopath Day

National Solitaire Day

National Sovereignty Day (Haiti)

National Title Track Day

National Toothpaste Tube Day

NF2 & Schwannomatosis Awareness Day

Pac-Man Day

Recliner Day

Republic Day (Sri Lanka)

Sherlock Holmes Day [also 1.6]

Toothpaste Tube Day

Translation of the Relics of Saint Nicholas from Myra to Bari (Ukraine)

Unification Day (Yemen)

United States Colored Troops Day

Unity Day (Yemen)

Watch Movies All Day Day

World Goth Day

World Pre-Eclampsia Day

Food & Drink Celebrations

Bitcoin Pizza Day

National Craft Distillery Day

Vanilla Pudding Day

World Paloma Day

4th Monday in May

Victoria Day (Canada) [Monday before 25th]

Independence Days

Dale Empire (Declared; 201) [unrecognized]

Feast Days

Basiliecus, Bishop of Corinna (Christian; Saint)

Biological Diversity Day (Pastafarian)

Bobo (Christian; Saint)

Castus and Emilius (a.k.a. Cactus and Æmilius; Christian; Martyrs)

Conall (Christian; Saint)

Elphinstone Day (Church of the SubGenius; Saint)

Fulk (Christian; Saint)

Humilita (Christian; Saint)

Julia of Corsica (Christian; Saint)

The Mackerel (Muppetism)

Mary Cassatt (Artology)

Michael Hồ Đình Hy (Christian; One of Vietnamese Martyrs)

Quiteria (Christian; Saint)

Ragnar Lodbrok (Viking)

Rita of Cascia (Christian; Saint)

Romanus of Subiaco (Christian; Saint)

St. Cyprian (Positivist; Saint)

Yvo (Christian; Saint)

Lucky & Unlucky Days

Shakku (赤口 Japan) [Bad luck all day, except at noon.]

Premieres

Alien 3 (Film; 1992)

Bone Sweet Bone (WB MM Cartoon; 1948)

Bullwinkle Goes to Press or All the Moose That’s Fit to Print (Rocky & Bullwinkle Cartoon, S1, Ep. 52; 1960)

Claws for Alarm (WB MM Cartoon; 1954)

Clean Pastures (WB MM Cartoon; 1937)

Far and Away (Film; 1992)

Fear and Loathing in Las Vegas (Film; 1998)

The Four Seasons (Film; 1981)

The Girlfriend Experience (Film; 2009)

Great Expectations (Film; 1947)

Gunga Din, by Rudyard Kipling (Poem; 1890)

Headquarters, by The Monks (Album; 1967)

Imperial Woman, by Pearl S. Buck (Novel; 1956)

Indiana Jones and the Kingdom of the Crystal Skull (Film; 2008)

Mission Impossible (Film; 1996)

The Negotiator, by Frederick Forsyth (Novel; 1989)

Night at the Museum: Battle of the Smithsonian (Film; 2009)

The Opposite of Sex (Film; 1998)

Outland (Film; 1981)

Preacher (TV Series; 2016)

Rocketman (Film; 2019)

That’s What You Get, by the Castiles featuring Bruce Springsteen (Song; 1966)

Tomorrowland (Film; 2015)

Water on the Brain or The Deep Six and 7/8 (Rocky & Bullwinkle Cartoon, S1, Ep. 51; 1960)

Well Worn Daffy (WB LT Cartoon; 1965)

When Marnie Was There (Animated Film; 2015)

The Wind and the Lion (Film; 1975)

Today’s Name Days

Julia, Ortwin, Rita (Austria)

Julija, Rita (Croatia)

Emil (Czech Republic)

Castus (Denmark)

Leivo, Oliver (Estonia)

Hemminki, Hemmo (Finland)

Émile, Quitter, Rita (France)

Julia, Ortwin, Renate, Rita (Germany)

Emilios, Kodros (Greece)

Júlia, Rita (Hungary)

Rita, Valente (Italy)

Emīlija, Mile (Latvia)

Aldona, Eimantas, Elena, Julija, Rita (Lithuania)

Henning, Henny (Norway)

Emil, Helena, Jan, Julia, Krzesisława, Rita, Wiesław, Wiesława, Wisława (Poland)

Vasilisc (România)

Júlia, Juliana (Slovakia)

Joaquina, Julia, Rita (Spain)

Hemming, Henning (Sweden)

Jolee, Joleen, Jolene, Jolie, Marshall (USA)

Today is Also…

Day of Year: Day 142 of 2024; 223 days remaining in the year

ISO: Day 1 of week 21 of 2023

Celtic Tree Calendar: Huath (Hawthorn) [Day 9 of 28]

Chinese: Month 4 (Ding-Si), Day 4 (Geng-Chen)

Chinese Year of the: Rabbit 4721 (until February 10, 2024)

Hebrew: 2 Sivan 5783

Islamic: 2 Dhu al-Qada 1444

J Cal: 21 Bīja; Sevenday [21 of 30]

Julian: 9 May 2023

Moon: 9%: Waxing Crescent

Positivist: 2 St. Paul (6th Month) [St. Cyprian]

Runic Half Month: Ing (Expansive Energy) [Day 13 of 15]

Season: Spring (Day 64 of 90)

Zodiac: Gemini (Day 2 of 32)

[brookston]

Holidays 5.22

Holidays

Abolition Day (Martinique)

Air Force Day (Brazil)

Arbor Day (Ecuador, Guatemala)

Bălți Day (Moldova)

Bear Waking Day (Norway)

Buy A Musical Instrument Day

Canadian Immigrants' Day

Carpet Day (Turkmenistan)

The Carter’s Race (Ancient Scotland)

Children’s Day (Switzerland)

Clover Day (French Republic)

Day of Hungarian Nature (Hungary)

Dia do Abraço (National Hugging Day; Brazil)

EMS Education Day

Ethernet Day

Ewokalypse

Find Your Soul Mate Day

Flag Adoption Day (Australia)

The Ghosts of the Battle of St. Alban Day (Ancient England)

Girl Scout Day (Japan)

Goth Day

Growing Flavor in the Garden Day

Harvey Milk Day (California)

Heat Awareness Safety Day

International Being You Day

International Building Safety Day

International Coco Mom Day

International Day For Biological Diversity (UN)

International Day of Syndrome 22q11

International Sherlock Holmes Day

Jumping Frog Jubilee Day (Angel's Camp, California)

Lee Rigby Memorial Day

Leiria Day (Portugal)

Loch Ness Monster Day

Manchester Arena Remembrance / 22 Angels Day (UK)

Mattie Stepanek Day (Rockville, Maryland)

Mr. Rogers' Neighborhood Day

National Boss Babe Day

National Coco Mom Day

National Curly Hair Day

National Day (Yemen)

National Day of First Nations Fishing Rights (Canada)

National Desert Storm Reservists Day

National Emergency Services for Children Day

National Gout Awareness Day

National Heroes Day (Sri Lanka)

National Julie Day

National Maritime Day

National Psychopath Day

National Solitaire Day

National Sovereignty Day (Haiti)

National Toothpaste Tube Day

NF2 & Schwannomatosis Awareness Day

143 Day (Pennsylvania)

Pac-Man Day

Recliner Day

Republic Day (Sri Lanka)

Sherlock Holmes Day [also 1.6]

The Soot Cat Games (Ancient Scotland)

Toothpaste Tube Day

Translation of the Relics of Saint Nicholas from Myra to Bari (Ukraine)

United States Colored Troops Day

Unity Day (Yemen)

Watch Movies All Day Day

World Goth Day

World Orienteering Day

World Pre-Eclampsia Day

Food & Drink Celebrations

Bitcoin Pizza Day

National Cheese Blintz Day

National Craft Distillery Day

Vanilla Pudding Day

World Paloma Day

Independence & Related Days

Dale Empire (Declared; 201) [unrecognized]

Montenegro (from Serbia, 2006) [observed]

Unification Day (Yemen)

4th Wednesday in May

Emergency Medical Services for Children Day [4th Wednesday]

National Brown Bag It Day [Last Wednesday; also 5.25]

National Senior Health and Fitness Day [Last Wednesday]

World Orienteering Day [4th Wednesday]

World Otter Day [Last Wednesday]

Festivals Beginning May 22, 2024

Bergen International Festival (Bergen, Norway) [thru 5.27]

Lightning in a Bottle (Bakersfield, California) [thru 5.27]

Soul Beach Music Festival (Oranjestad, Aruba) [thru 5.27]

Spoleto Festival USA (Spoleto, South Carolina( [thru 6.5]

Strawberry Music Festival(Grass Valley, California) [thru 5.27]

Feast Days

Amalia Lindegren (Artology)

Basiliecus, Bishop of Corinna (Christian; Saint)

Belmiro de Almeida (Artology)

Biological Diversity Day (Pastafarian)

Bobo (Christian; Saint)

Caer Gwydion (Milky Way Day; Celtic Book of Days)

Castus and Emilius (a.k.a. Cactus and Æmilius; Christian; Martyrs)

Conall (Christian; Saint)

Daniel Gran (Artology)

Elphinstone Day (Church of the SubGenius; Saint)

Feast of Elen Ludyddog, of the Ways, of Old Track and Wells (Starza Pagan Book of Days)

Félix Bracquemond (Artology)

Feralia (Day of Purification; Pagan)

Fritz von Uhde (Artology)

Fulk (Christian; Saint)

Hubert Robert (Artology)

Humilita (Christian; Saint)

Jean Tinguely (Artology)

Johann Nepomuk Schödlberger (Artology)

Julia of Corsica (Christian; Saint)

Julius Klinger (Artology)

The Mackerel (Muppetism)

Mary Cassatt (Artology)

Michael Hồ Đình Hy (Christian; One of Vietnamese Martyrs)

Quiteria (Christian; Saint)

Ragnar Lodbrok (Viking)

Richard Brakenburgh (Artology)

Rita of Cascia (Christian; Saint)

Romanus of Subiaco (Christian; Saint)

St. Cyprian (Positivist; Saint)

St. Nicholas Day (Serbia)

Toad-Pinching Day (Pixies; Shamanim)

Tomás Sánchez (Artology)

Worthington Whittredge (Artology)

Yvo (Christian; Saint)

Lunar Calendar Holidays

Buddha Day [Around 5th Full Moon of the Year] (a.k.a. ... 

Buddha Jayanti (Nepal)

Buddha Purnima (Parts of India)

Buddha Purnuma (Bangladesh)

Hari Raya Waisaki (Indonesia)

Lord Buddha’s Parinirvana (Bhutan)

Saga Dawa (Sikkim, India)

Shyadar Pidar (Parts of India)

Vesak Day (Singapore, Sri Lanka)

Visakha Bucha Day (Thailand)

Visakh Bochea (Cambodia)

Wesak (Malaysia)

Lucky & Unlucky Days

Shakku (赤口 Japan) [Bad luck all day, except at noon.]

Premieres

Alien 3 (Film; 1992)

Beau Best (Oswald the Lucky Rabbit Cartoon; 1933)

Bomb Voyage (The Inspector Cartoon; 1967)

Bone Sweet Bone (WB MM Cartoon; 1948)

Bullwinkle Goes to Press or All the Moose That’s Fit to Print (Rocky & Bullwinkle Cartoon, S1, Ep. 52; 1960)

Claws for Alarm (WB MM Cartoon; 1954)

Clean Pastures (WB MM Cartoon; 1937)

Custer Died for Your Sins: An Indian Manifesto, by Vine Deloria Jr. (Political Theory; 1969)

The Dispossessed: An Ambiguous Utopia, by Ursula K. Le Guin (Novel; 1974)

Eye of the Needle, by Ken Follett (Novel; 1978)

Far and Away (Film; 1992)

Fear and Loathing in Las Vegas (Film; 1998)

Flashman, by George MacDonald Fraser (Novel; 1969)

The Four Seasons (Film; 1981)

The Girlfriend Experience (Film; 2009)

Great Expectations (Film; 1947)

Gunga Din, by Rudyard Kipling (Poem; 1890)

Headquarters, by The Monks (Album; 1967)

Imperial Woman, by Pearl S. Buck (Novel; 1956)

Indiana Jones and the Kingdom of the Crystal Skull (Film; 2008)

The Italian Girl in Algiers (L’italiana in Algeria), by Gioachino Rossini (Opera; 1813)

The Lonesome Mouse (Tom & Jerry Cartoon; 1943)

Mission Impossible (Film; 1996)

The Negotiator, by Frederick Forsyth (Novel; 1989)

Night at the Museum: Battle of the Smithsonian (Film; 2009)

The Opposite of Sex (Film; 1998)

Outland (Film; 1981)

The Pink Quarterback (Pink Panther Cartoon; 1968)

Popeye’s Birthday (Fleischer/Famous Popeye Cartoon; 1953)

Preacher (TV Series; 2016)

Rocketman (Film; 2019)

Stiff Upper Lip, Jeeves, by P.G. Wodehouse (Novel; 1963) [Jeeves #13]

That’s What You Get, by the Castiles featuring Bruce Springsteen (Song; 1966)

Thousand Cranes, by Yasunari Kawabata (Novel; 1952)

Tintin and Alph-Art, by Hergé (Graphic Novel; 1986) [Tintin #24]

Tomorrowland (Film; 2015)

Water on the Brain or The Deep Six and 7/8 (Rocky & Bullwinkle Cartoon, S1, Ep. 51; 1960)

The Weary Blues, by Langston Hughes (Poem; 1925)

Well Worn Daffy (WB LT Cartoon; 1965)

When Marnie Was There (Animated Film; 2015)

The Wind and the Lion (Film; 1975)

Today’s Name Days

Julia, Ortwin, Rita (Austria)

Julija, Rita (Croatia)

Emil (Czech Republic)

Castus (Denmark)

Leivo, Oliver (Estonia)

Hemminki, Hemmo (Finland)

Émile, Quitter, Rita (France)

Julia, Ortwin, Renate, Rita (Germany)

Emilios, Kodros (Greece)

Júlia, Rita (Hungary)

Rita, Valente (Italy)

Emīlija, Mile (Latvia)

Aldona, Eimantas, Elena, Julija, Rita (Lithuania)

Henning, Henny (Norway)

Emil, Helena, Jan, Julia, Krzesisława, Rita, Wiesław, Wiesława, Wisława (Poland)

Vasilisc (România)

Júlia, Juliana (Slovakia)

Joaquina, Julia, Rita (Spain)

Hemming, Henning (Sweden)

Jolee, Joleen, Jolene, Jolie, Marshall (USA)

Today is Also…

Day of Year: Day 143 of 2024; 223 days remaining in the year

ISO: Day 3 of week 21 of 2024

Celtic Tree Calendar: Huath (Hawthorn) [Day 11 of 28]

Chinese: Month 4 (Ji-Si), Day 14 (Bing-Xu)

Chinese Year of the: Dragon 4722 (until January 29, 2025) [Wu-Chen]

Hebrew: 14 Iyar 5784

Islamic: 14 Dhu al-Qada 1445

J Cal: 23 Magenta; Twosday [23 of 30]

Julian: 9 May 2024

Moon: 99%: Waxing Gibbous

Positivist: 2 St. Paul (6th Month) [St. Cyprian]

Runic Half Month: Ing (Expansive Energy) [Day 13 of 15]

Season: Spring (Day 65 of 92)

Week: 3rd Full Week of May

Zodiac: Gemini (Day 2 of 31)

[leedsomics]

Spatial Transcriptomics of Spinal Ependymoma in NF2-related Schwannomatosis

Spinal ependymoma (SP-EPN) is a central nervous system (CNS) tumor that is associated with high morbidity. The only effective treatment for end-stage SP-EPN is surgery, but this is associated with high risk of injury to the sensorimotor spinal tracts and paralysis. There is a critical need to understand the cellular origins of this tumor so that disease models of tumor progression can be generated for drug development. Recent genomic studies with bulkRNA sequencing suggest the molecular signature of SP-EPN matches that of ependymal cells (EPCs). However, large-scale genomic studies can often misrepresent rare cancer stem cell populations within the tumor. In this study, we performed spatial transcriptomics (ST) on a SP-EPN resected from a patient with NF2-related neurofibromatosis to examine the spatial heterogeneity within the tumor. The SP-EPN sample exhibited cellular heterogeneity with diffuse expression of astrocytic and EPC markers, and smaller pockets with RGC or stem cell markers, as well as overlap between progenitor cell and mature cell markers. These findings suggest that there may be a developmental hierarchy within the EPC lineage in SP-EPN tumors, which may stem from aberrant radial glia cells. http://dlvr.it/T3kkNt

[chuckschmalzried]

Woman Had 75 MRIs 11 Surgeries and 100 Tumors Including 3 in Her Brain. Find Out Why.

Woman Had 75 MRIs, 11 Surgeries, and 100 Tumors, Including 3 in Her Brain. Find Out Why. https://theheartysoul.com/michele-holbrook-neurofibromatosis-schwannomatosis/ Michele Holbrook is an extraordinary woman who has faced unimaginable challenges throughout her life. Living with a rare genetic condition called neurofibromatosis, she has endured 75 MRIs, 11 surgeries, and the presence of over 100 tumors in her body, including three in her brain. This is her incredible story, how her condition has impacted her […] The post Woman Had 75 MRIs, 11 Surgeries, and 100 Tumors, Including 3 in Her Brain. Find Out Why. appeared first on The Hearty Soul. via The Hearty Soul https://theheartysoul.com/ February 08, 2024 at 03:48PM

[the-rachana]

Neurofibromatosis Market – Breaking Barriers, Inspiring Hope: Transforming the Neurofibromatosis Landscape Together

The Neurofibromatosis Market Report assists in determining the optimum distribution methods for certain products as well as possible markets for future product launches. The report also analyses the purchase and supply trends that influence the market’s production strategy. The Neurofibromatosis market research study is one of the most detailed market research reports available, highlighting the Neurofibromatosis industry’s constraints, market trends, opportunities, driving factors, emerging trends, product types, applications, and competition.

Get a Sample PDF of the Report: 

You can get insights into comprehensive TOC, Tables, and Charts presented throughout the report for valuable data, information, important statistics, trends, and detailed competitive landscape information in this market.

Neurofibromatosis Market TOC: 

The following are the leading companies in the global Neurofibromatosis market: 

AstraZeneca Plc.

Merck & Co. Inc.

Nflection Therapeutics

Chia Tai Tianqing Pharmaceutical Group Co. Ltd.

Array BioPharma

Healx

GL Pharma Tech Corporation

ABM Therapeutics Corporation

Recursion Pharmaceuticals Inc.

Growth Plus Reports analyses the important trends in each segment and sub-segment of the Neurofibromatosis market, as well as forecasts at the global and regional levels from 2023 to 2031. The market has been segmented in our report based on product type and application.

SEGMENTS

GLOBAL NEUROFIBROMATOSIS MARKET – ANALYSIS & FORECAST, BY TYPE

NF1

NF2

Schwannomatosis

GLOBAL NEUROFIBROMATOSIS MARKET – ANALYSIS & FORECAST, BY DRUG CLASS

Antihistamines

Antineoplastic Agents

Selumetinib 

Carboplatin

Lomustine

Vincristine

Others

Anti-Inflammatory Drugs

GLOBAL NEUROFIBROMATOSIS MARKET – ANALYSIS & FORECAST, BY DISTRIBUTION CHANNEL

Hospital Pharmacies

Retail Pharmacies

Online Pharmacies

For More Information or Query or Customization visit: 

Businesses can use Neurofibromatosis market reports to learn more about market drivers and market limitations, which can help them decide whether to reduce or increase the production of a specific product. As globalization increases, many organizations require global market research that includes practical market data to improve strategic planning. This global Neurofibromatosis market report analyses key market dynamics and provides comprehensive statistics and information for business growth. To carry out the Neurofibromatosis market research study, professional and sophisticated methods and techniques such as SWOT analysis, and GRG Health’s unique GrowthMIX strategy were used.

The report is beneficial in providing information regarding several important questions that are vital for the market players such as manufacturers and partners, end users, etc. while assisting them in planning investments and capitalizing on market potential.

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[lupine-publishers-juns]

Lupine Publishers | A Rare Case of Penile Schwannomatosis Presenting with Painful Nocturnal Penile Tumescence

Abstract

Background: Penile schwannoma is a rare tumor. They commonly present as an asymptomatic, painless and slow growing mass. Other presentations include sexual dysfunction, most commonly dyspareunia, followed by erectile dysfunction, abnormal penile curvature or pain with ejaculation. Case presentation: A 26-year-old male presented atypically with painful nocturnal penile tumescence, along with multiple nodules over the dorsal penis. Excision of multiple penile tumors under general anaesthesia was performed and histopathologic examination revealed benign schwannoma. Conclusion: Our hypothesis is that the schwannoma lies along the axis of the dorsal penile nerve, and compression of this nerve occurs during his erection causing pain. However, there are limited presentations of painful erections in penile schwannomas, and we hope that future studies can help confirm this theory.

Keywords: Penile; schwannoma; painful tumescence; sexual dysfunction

Background

Schwannomas are a form of peripheral nerve tumors made up of neoplastic Schwann cells that typically occur as solitary, encapsulated masses. They can occur throughout the body, but more commonly arise on the head, neck, or flexor surfaces of limbs [1,2]. The tumors are sporadically associated with genetic syndromes such as schwannomatosis and neurofibromatosis or may be the result of therapeutic irradiation [3]. Schwannomas have a low annual incidence of 0.6 per 100,000 people [4]. These are rare and only 27 cases have been reported in literature since it was first described in 1968 [5]. Penile schwannomas are typically asymptomatic, painless and slow growing. Possible presentations include sexual dysfunction, most commonly dyspareunia, followed by erectile dysfunction, abnormal penile curvature, or pain with ejaculation. Our patient presented with painful nocturnal penile tumescence, which is not a well-known presentation of penile schwannomas. There is limited published literature on such cases and hence little is known about this condition (Figures 1&2).

Case Presentation

A 26-year-old man with a history of ankylosing spondylitis (HLA B27 gene) and previous circumcision first presented with a oneyear history of recurrent painful nocturnal erections. He had prior consultations with various urologists and did not respond to oral analgesia. The frequency of painful nocturnal erections increased from once per week, to thrice per week over the past year. Each episode of painful nocturnal tumescence lasted approximately five minutes and the patient was often awaken from sleep by the severe pain, which affected his sleep and quality of life (Figure 3). There was no history of priapism, sexual transmitted disease, or genital trauma. There were no persons with known neurofibromatosis in his family. On examination, four lumps could be palpated over the dorsum of the stretched penis. Two were superficial nodules on the distal shaft, with one deep nodule each at the mid shaft and base of the penis. The nodules were 0.5cm or less in diameter and firm in nature. The mid shaft nodule was tender on palpation and correlated with the site of painful nocturnal erections. The penis was otherwise unremarkable and there was neither penile curvature on erection nor any palpable lymph nodes in the femoral or inguinal areas. Nodules or café-au-lait spots were not present in the rest of the body (Figure 4). Over a five-year follow-up, patient developed worsening symptoms with the painful erections occurring twice every night from one episode a week. Physical examination and interval ultrasound imaging demonstrated an increase in the number of nodules from four to five with further growth of the existing nodules. Most noticeably, the right intracavernosal nodule increased from 4 mm to 7 mm in diameter. The patient decided for surgical excision of multiple penile nodules (Figures 5&6).

Investigations

Laboratory findings included normal blood cell counts, chemistries and urinalysis. Initial ultrasound penis showed multiple rounded heterogeneously echogenic nodules in the subcutaneous region of the dorsal penile shaft. The nodules show minimal central and peripheral vascularity. A small cystic lesion with internal echoes is also noted in the corpus cavernosum. The patient initially declined surgical intervention and opted for annual ultrasound imaging (Figure 7). Magnetic resonance imaging (MRI) of the penis performed prior to surgery showed multiple enhancing sub-centimetre nodules in the penile shaft, most of which were superficial. There was a nodule in the right corpus cavernosum, and another in the dorsal midline which disrupts the wall of both corpora cavernosa.

Treatment

Patient underwent excision of multiple penile tumors under general anaesthesia. A circumferential incision was made at the previous circumcision site. The penis was then degloved to its base and the layers dissected down to Buck’s fascia. There were five superficial tumors adherent to the tunica albuginea (two at right distal shaft, two at midshaft, one at base of penis). A deep-seated tumor was located at the right corporal mid shaft. The tumors measured approximately 1-1.5cm in diameter (Figure 8). The cut surface of the tumors was homogenously yellowish with noted feeding vessels. All tumors were excised, and histology was sent from all locations.

Outcome and Follow-Up

All specimens show similar morphology. The circumscribed and thinly encapsulated nodules were made up of Schwann cells arranged as a mixture of more cellular Antoni A and less cellular Antoni B areas. The more cellular Antoni A areas consists of Schwann cells arranged as short fascicles or parallel rows of nuclear pallisading (Verocay bodies). The less cellular Antoni B areas show a looser myxoid stroma. The nodules are associated with thickened and oedematous nerve fibres, and occasional more plexiform Schwannian areas are seen involving the nerve fibres (Figures 9&10). No high-grade nuclear atypia, increased mitosis or tumour necrosis is seen. On immunostaining, the lesion shows diffuse staining with S-100, which is indicative of Schwannoma. In the follow up consultations over a year after surgery, there was no further nightly painful erections and patient was able to sleep well. On examination there is a small nodularity at mid shaft which is likely due to scar tissue formation. However, the patient did experience difficulty maintaining erection due to discomfort over the surgical site. This was managed well with Viagra 25mg, with an improvement in International Index of Erectile Function score from 8/25 to 19/25. Patient declined genetic testing as he was not keen on childbearing.

Discussion

Schwannomas rarely present with penile pain. There have been postulations made regarding the correlation of symptoms to neuroanatomy. A literature review done by Huang et al. concluded that patients with penile root schwannomas are more prone to symptoms with discomfort or sexual dysfunction (4 of 6) compared with patients with penile shaft schwannoma (7 of 16) or glans schwannoma (2 of 7) [6]. Based on anatomy, penile schwannomas at the mid shaft or glans should originate from the dorsal nerve of the penis, which is the deepest division of the pudendal nerve. The pudendal nerve does pass through the penile root, but there is no clear branching or tracking of the nerve origin of the tumor [7]. Pain may occur in the region of the tumor and any nerve the tumor originates from, but pain may not be specific enough to discern the particular involved nerve. Neurologic deficits of sensory and motor function correspond to the nerve in which the tumor originates or which it is compressing, and as such will often be most useful in localizing the tumor [8,9]. This patient presented with painful nocturnal erections corresponding to the mid shaft schwannoma. Our hypothesis is that the mid shaft schwannoma lies along the axis of the dorsal penile nerve and pain could arise when the nerve is compressed by the schwannoma during full erection. During nocturnal tumescence, the cavernosus arteries dilate, leading to engorgement of the corpora cavernosa and increase of intracorporal pressure. This pushes the schwannoma towards the dorsal penile nerve leading to nerve irritation, compression and pain. Penile schwannomas normally occur at the dorsal penile shaft. However, there have been documented cases where the tumor has infiltrated the glans and prepuce [10]. In such cases, we have to consider other possible diagnoses including benign soft-tissue lesions such as lipoma, fibroma, leiomyoma, Peyronie’s disease, injection-related fibrosis, and rarely malignant sarcomas. Clinical history taking and clinical examination are important, but imaging can aid in narrowing the differentials by locating the plane of the lesion and delineating the mass. Ultrasound examination can demonstrate hypoechoic lesions, and doppler ultrasound can detect hypervascularity. CT scan is rarely used, and mostly performed to exclude metastasis. Schwannomas demonstrate typical MRI features of T1 isointensity to hypointensity, T2 hyperintensity, and postcontrast enhancement. Heterogeneous signal intensity and postcontrast enhancement are suggestive of internal hemorrhage and myxoid/cystic changes [11]. Otherwise, excision biopsy of the tumor would be the gold standard for final diagnosis. Treatment of penile schwannomas is symptomatic, focused primarily on pain management. Complete surgical excision is the recommended treatment for penile schwannomas, with low recurrence rates [1- 10]. This patient recovered well with no signs of recurrence one year postoperatively. Schwannomas of the penis are usually benign, but four malignant variants have been reported in literature. No cases of benign penile schwannoma have been reported to be associated with hereditary diseases [12]. Schwannomatosis is the third major form of neurofibromatosis, and is characterized by a predisposition for schwannomas, in the absence of schwannomas on both vestibular nerves. Its diagnosis is based on a criterion [13]. Most patients present in adulthood with multiple schwannomas and pain, and approximately 20 percent of patients have a family history of schwannomas or schwannomatosis [14]. So far, there have been no confirmed causes of penile schwannoma with schwannomatosis. There is no strong evidence about the correlation between schwannoma and erectile dysfunction [15]. This patient’s postoperative erectile dysfunction is likely due to pain surrounding the surgical wound site. Also, there were no surgical complications other than possible scar tissue formation on the penile shaft.

Conclusion

Schwannomas of the penis are extremely rare and typically present as a solitary, asymptomatic, painless and slow-growing tumor. The rarity in this case is that our patient presented with painful nighttime erections. Based on the penile neuroanatomy, penile schwannomas at the mid shaft should originate from the dorsal nerve of the penis. Our hypothesis is that the schwannoma lies along the axis of the dorsal penile nerve and compression of this nerve occurs during his erection causing pain. However, there are limited presentations of painful erections in penile schwannomas, and we hope that future studies can help confirm this theory.

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For more  Journal of Urology & Nephrology Studies  articles please click here: https://lupinepublishers.com/urology-nephrology-journal/index.php

[medserg]

What are the signs and symptoms of Neurofibromatosis?

Neurofibromatosis is divided into three categories, each with its own set of signs and symptoms:

Neurofibromatosis 1 – Neurofibromatosis type 1 (NF1) is most commonly diagnosed in children. Signs are frequently visible from birth or shortly thereafter, and almost usually by the age of ten. The signs and symptoms are usually mild to moderate, but the severity might vary.

The following are some of the signs and symptoms of NF1:

Skin with flat, light brown patches

Freckling in the genital area or armpits

Little bumps on the eye’s iris.

Soft, pea-sized lumps on or beneath the skin

Deformities of the bones

Tumor on the optic nerve

Disabilities in learning

Head size that is larger than average

Small stature

Neurofibromatosis 2 – Neurofibromatosis type 2 (NF2) is substantially less prevalent than neurofibromatosis type 1. The development of benign, slow-growing tumors in both ears (acoustic neuromas), which can cause hearing loss, is frequently the source of NF2 signs and symptoms. These tumors, also known as vestibular schwannomas, develop on the nerve that transmits sound and balance information from the inner ear to the brain.

The signs and symptoms usually occur in the teenage years, and they can be mild or severe. The following are examples of signs and symptoms of neurofibromatosis 2:

Gradual loss of hearing

The ears are ringing.

Uneven balance

Headaches

Other nerves, such as the cranial, spinal, visual (optic), and peripheral nerves, can sometimes develop schwannomas as a result of NF2. Other benign tumors can develop in people with NF2.

These tumors can cause the following signs and symptoms:

Numbness and weakness in the arms or legs

Pain

Balance difficulties

Facial drop

Vision problems or cataracts

Seizures

Headache

Schwannomatosis – Neurofibromatosis is a rare type of neurofibromatosis that mainly strikes persons when they reach the age of 20. Between the ages of 25 and 30, symptoms begin to show. Schwannomatosis causes tumors to form on the cranial, spinal, and peripheral nerves, but not on the nerve that transmits sound and balance information from the inner ear to the brain. Because tumors usually form on both hearing nerves, patients with schwannomatosis do not have the same hearing loss as those with NF2.

The following are some of the signs and symptoms of schwannomatosis:

Chronic pain can affect any part of the body and can be debilitating.

Numbness or weakness in various bodily areas

Muscle atrophy

What are the Causes of Neurofibromatosis?

Neurofibromatosis is generally an autosomal dominant hereditary condition. This means that only one copy of a mutant gene is required to cause the disease, and patients’ children have a 50:50 chance of acquiring it.

In up to 50% of cases, neurofibromatosis is caused by a spontaneous mutation (change). The change in genes can be transmitted down to the following generation once it occurs.

Risk factors: A family history of neurofibromatosis is the most significant risk factor for the disease. About half of those with NF1 and NF2 got the condition from a parent who had it. People with NF1 and NF2 who have no affected relatives are likely to have a novel gene mutation.

How the diagnosis of Neurofibromatosis is done?

Your doctor will begin with a physical examination and a review of your personal and family medical history. Your doctor will look for brown patches on your skin, which can aid in the diagnosis of NF1.

If your doctor believes more tests are needed to diagnose NF1, NF2, or schwannomatosis, he or she may suggest:

Examination of eyes: Cataract and vision loss.

Balance and hearing exams: Audiometry is a test that evaluates hearing, and electrophysiology is a test that records your eye movements using electrodes (electronystagmography).

Imaging Tests: X-rays, CT scans, and MRIs.

Genetic tests: NF1 and NF2 tests are available and can be done throughout pregnancy before the baby is born. Inquire with your doctor about genetic counseling.

At least two symptoms of NF1 must be present in order to be diagnosed. If your child has only one symptom and no family history of NF1, your doctor will most likely keep an eye on him or her for any additional symptoms. NF1 is commonly diagnosed by the age of four.

[thefitzproject]

My name is Fitz and I was diagnosed with Neurofibromatosis at the age of 14. I have NF3 which is called schwannomatosis. I have been struggling with this condition ever since. Follow me on my journey as I try to survive NF. I’m looking forward to hearing from other survivors.

[neurofibromemetosis]

[aceoffangirls]

NF AWARENESS DAY

Today Neurofibromatosis (NF) Awareness Day.

NF is a group of complex genetic conditions that cause tumours to form on the nerves throughout the body.

NF includes Neurofibromatosis type 1 (NF1), Neurofibromatosis Type 2 and Schwannomatosis.

[smokesforharris]

Young Adult International Summit.

Connect with other NF Young Adults.

[brookstonalmanac]

Holidays 5.22

Holidays

Abolition Day (Martinique)

Air Force Day (Brazil)

Arbor Day (Ecuador, Guatemala)

Bălți Day (Moldova)

Bear Waking Day (Norway)

Buy A Musical Instrument Day

Canadian Immigrants' Day

Carpet Day (Turkmenistan)

The Carter’s Race (Ancient Scotland)

Children’s Day (Switzerland)

Clover Day (French Republic)

Day of Hungarian Nature (Hungary)

Dia do Abraço (National Hugging Day; Brazil)

EMS Education Day

Ethernet Day

Ewokalypse

Find Your Soul Mate Day

Flag Adoption Day (Australia)

The Ghosts of the Battle of St. Alban Day (Ancient England)

Girl Scout Day (Japan)

Goth Day

Growing Flavor in the Garden Day

Harvey Milk Day (California)

Heat Awareness Safety Day

International Being You Day

International Building Safety Day

International Coco Mom Day

International Day For Biological Diversity (UN)

International Day of Syndrome 22q11

International Sherlock Holmes Day

Jumping Frog Jubilee Day (Angel's Camp, California)

Lee Rigby Memorial Day

Leiria Day (Portugal)

Loch Ness Monster Day

Manchester Arena Remembrance / 22 Angels Day (UK)

Mattie Stepanek Day (Rockville, Maryland)

Mr. Rogers' Neighborhood Day

National Boss Babe Day

National Coco Mom Day

National Curly Hair Day

National Day (Yemen)

National Day of First Nations Fishing Rights (Canada)

National Desert Storm Reservists Day

National Emergency Services for Children Day

National Gout Awareness Day

National Heroes Day (Sri Lanka)

National Julie Day

National Maritime Day

National Psychopath Day

National Solitaire Day

National Sovereignty Day (Haiti)

National Toothpaste Tube Day

NF2 & Schwannomatosis Awareness Day

143 Day (Pennsylvania)

Pac-Man Day

Recliner Day

Republic Day (Sri Lanka)

Sherlock Holmes Day [also 1.6]

The Soot Cat Games (Ancient Scotland)

Toothpaste Tube Day

Translation of the Relics of Saint Nicholas from Myra to Bari (Ukraine)

United States Colored Troops Day

Unity Day (Yemen)

Watch Movies All Day Day

World Goth Day

World Orienteering Day

World Pre-Eclampsia Day

Food & Drink Celebrations

Bitcoin Pizza Day

National Cheese Blintz Day

National Craft Distillery Day

Vanilla Pudding Day

World Paloma Day

Independence & Related Days

Dale Empire (Declared; 201) [unrecognized]

Montenegro (from Serbia, 2006) [observed]

Unification Day (Yemen)

4th Wednesday in May

Emergency Medical Services for Children Day [4th Wednesday]

National Brown Bag It Day [Last Wednesday; also 5.25]

National Senior Health and Fitness Day [Last Wednesday]

World Orienteering Day [4th Wednesday]

World Otter Day [Last Wednesday]

Festivals Beginning May 22, 2024

Bergen International Festival (Bergen, Norway) [thru 5.27]

Lightning in a Bottle (Bakersfield, California) [thru 5.27]

Soul Beach Music Festival (Oranjestad, Aruba) [thru 5.27]

Spoleto Festival USA (Spoleto, South Carolina( [thru 6.5]

Strawberry Music Festival(Grass Valley, California) [thru 5.27]

Feast Days

Amalia Lindegren (Artology)

Basiliecus, Bishop of Corinna (Christian; Saint)

Belmiro de Almeida (Artology)

Biological Diversity Day (Pastafarian)

Bobo (Christian; Saint)

Caer Gwydion (Milky Way Day; Celtic Book of Days)

Castus and Emilius (a.k.a. Cactus and Æmilius; Christian; Martyrs)

Conall (Christian; Saint)

Daniel Gran (Artology)

Elphinstone Day (Church of the SubGenius; Saint)

Feast of Elen Ludyddog, of the Ways, of Old Track and Wells (Starza Pagan Book of Days)

Félix Bracquemond (Artology)

Feralia (Day of Purification; Pagan)

Fritz von Uhde (Artology)

Fulk (Christian; Saint)

Hubert Robert (Artology)

Humilita (Christian; Saint)

Jean Tinguely (Artology)

Johann Nepomuk Schödlberger (Artology)

Julia of Corsica (Christian; Saint)

Julius Klinger (Artology)

The Mackerel (Muppetism)

Mary Cassatt (Artology)

Michael Hồ Đình Hy (Christian; One of Vietnamese Martyrs)

Quiteria (Christian; Saint)

Ragnar Lodbrok (Viking)

Richard Brakenburgh (Artology)

Rita of Cascia (Christian; Saint)

Romanus of Subiaco (Christian; Saint)

St. Cyprian (Positivist; Saint)

St. Nicholas Day (Serbia)

Toad-Pinching Day (Pixies; Shamanim)

Tomás Sánchez (Artology)

Worthington Whittredge (Artology)

Yvo (Christian; Saint)

Lunar Calendar Holidays

Buddha Day [Around 5th Full Moon of the Year] (a.k.a. ... 

Buddha Jayanti (Nepal)

Buddha Purnima (Parts of India)

Buddha Purnuma (Bangladesh)

Hari Raya Waisaki (Indonesia)

Lord Buddha’s Parinirvana (Bhutan)

Saga Dawa (Sikkim, India)

Shyadar Pidar (Parts of India)

Vesak Day (Singapore, Sri Lanka)

Visakha Bucha Day (Thailand)

Visakh Bochea (Cambodia)

Wesak (Malaysia)

Lucky & Unlucky Days

Shakku (赤口 Japan) [Bad luck all day, except at noon.]

Premieres

Alien 3 (Film; 1992)

Beau Best (Oswald the Lucky Rabbit Cartoon; 1933)

Bomb Voyage (The Inspector Cartoon; 1967)

Bone Sweet Bone (WB MM Cartoon; 1948)

Bullwinkle Goes to Press or All the Moose That’s Fit to Print (Rocky & Bullwinkle Cartoon, S1, Ep. 52; 1960)

Claws for Alarm (WB MM Cartoon; 1954)

Clean Pastures (WB MM Cartoon; 1937)

Custer Died for Your Sins: An Indian Manifesto, by Vine Deloria Jr. (Political Theory; 1969)

The Dispossessed: An Ambiguous Utopia, by Ursula K. Le Guin (Novel; 1974)

Eye of the Needle, by Ken Follett (Novel; 1978)

Far and Away (Film; 1992)

Fear and Loathing in Las Vegas (Film; 1998)

Flashman, by George MacDonald Fraser (Novel; 1969)

The Four Seasons (Film; 1981)

The Girlfriend Experience (Film; 2009)

Great Expectations (Film; 1947)

Gunga Din, by Rudyard Kipling (Poem; 1890)

Headquarters, by The Monks (Album; 1967)

Imperial Woman, by Pearl S. Buck (Novel; 1956)

Indiana Jones and the Kingdom of the Crystal Skull (Film; 2008)

The Italian Girl in Algiers (L’italiana in Algeria), by Gioachino Rossini (Opera; 1813)

The Lonesome Mouse (Tom & Jerry Cartoon; 1943)

Mission Impossible (Film; 1996)

The Negotiator, by Frederick Forsyth (Novel; 1989)

Night at the Museum: Battle of the Smithsonian (Film; 2009)

The Opposite of Sex (Film; 1998)

Outland (Film; 1981)

The Pink Quarterback (Pink Panther Cartoon; 1968)

Popeye’s Birthday (Fleischer/Famous Popeye Cartoon; 1953)

Preacher (TV Series; 2016)

Rocketman (Film; 2019)

Stiff Upper Lip, Jeeves, by P.G. Wodehouse (Novel; 1963) [Jeeves #13]

That’s What You Get, by the Castiles featuring Bruce Springsteen (Song; 1966)

Thousand Cranes, by Yasunari Kawabata (Novel; 1952)

Tintin and Alph-Art, by Hergé (Graphic Novel; 1986) [Tintin #24]

Tomorrowland (Film; 2015)

Water on the Brain or The Deep Six and 7/8 (Rocky & Bullwinkle Cartoon, S1, Ep. 51; 1960)

The Weary Blues, by Langston Hughes (Poem; 1925)

Well Worn Daffy (WB LT Cartoon; 1965)

When Marnie Was There (Animated Film; 2015)

The Wind and the Lion (Film; 1975)

Today’s Name Days

Julia, Ortwin, Rita (Austria)

Julija, Rita (Croatia)

Emil (Czech Republic)

Castus (Denmark)

Leivo, Oliver (Estonia)

Hemminki, Hemmo (Finland)

Émile, Quitter, Rita (France)

Julia, Ortwin, Renate, Rita (Germany)

Emilios, Kodros (Greece)

Júlia, Rita (Hungary)

Rita, Valente (Italy)

Emīlija, Mile (Latvia)

Aldona, Eimantas, Elena, Julija, Rita (Lithuania)

Henning, Henny (Norway)

Emil, Helena, Jan, Julia, Krzesisława, Rita, Wiesław, Wiesława, Wisława (Poland)

Vasilisc (România)

Júlia, Juliana (Slovakia)

Joaquina, Julia, Rita (Spain)

Hemming, Henning (Sweden)

Jolee, Joleen, Jolene, Jolie, Marshall (USA)

Today is Also…

Day of Year: Day 143 of 2024; 223 days remaining in the year

ISO: Day 3 of week 21 of 2024

Celtic Tree Calendar: Huath (Hawthorn) [Day 11 of 28]

Chinese: Month 4 (Ji-Si), Day 14 (Bing-Xu)

Chinese Year of the: Dragon 4722 (until January 29, 2025) [Wu-Chen]

Hebrew: 14 Iyar 5784

Islamic: 14 Dhu al-Qada 1445

J Cal: 23 Magenta; Twosday [23 of 30]

Julian: 9 May 2024

Moon: 99%: Waxing Gibbous

Positivist: 2 St. Paul (6th Month) [St. Cyprian]

Runic Half Month: Ing (Expansive Energy) [Day 13 of 15]

Season: Spring (Day 65 of 92)

Week: 3rd Full Week of May

Zodiac: Gemini (Day 2 of 31)