#Vasculature; Drive

[pandemic-info]

In Cleveland and beyond researchers begin to unravel the mystery of long COVID-19 - cleveland.com

Eerily similar to HIV

To be clear, McComsey isn’t suggesting that the viruses themselves are similar. Coronaviruses are not retroviruses like HIV, nor are they sexually transmitted like HIV. But it’s the way they make the people they infect sick that caught her attention. It hides in the body and continues to wreak havoc in the various organ system by driving inflammation and disrupting the immune response.

“HIV patients don’t die from the virus itself. They die from immune activation – from the high levels of inflammation that causes cancer, heart disease, liver and kidney disease,” she said.

“The only reason we cannot cure HIV is because the virus hides where the HIV drugs can’t go in. So it continues to fuel this high inflammation. That’s why somebody like me who has been studying HIV for the last 20 years found that COVID is extremely similar to HIV. It’s a virus that produces a lot of inflammation. We see a lot of conditions that are known to stem from inflammation, and now we have some evidence that it persists in different organs.”

McComsey is referring to various published research papers that suggest the SARS-Cov-2 may linger in various organ tissues long after nasal swabs and blood tests come back negative.

researchers have found that although one’s risk of developing long COVID increases with the severity of the initial infection, people can and do develop long COVID even after infections that were asymptomatic or considered mild.

... vaccination dramatically reduces a person’s chances of developing long COVID. A fully vaccinated individual is five times less likely to continue to have any symptoms or ill-effects three months after their initial infection compared to someone who has not been vaccinated. And that, said McComsey, makes a strong case for continued vaccination. “I’m not afraid of getting acute COVID,” she said. “I’m worried about Long COVID.”

...researchers have discovered that patients with long COVID generally have symptoms that fall into three categories or phenotypes: fatigue, neurocognitive symptoms such as brain fog or headaches, and cardiovascular symptoms such as shortness of breath, heart arrythmias, exercise intolerance, and blood clots. Patients may have more than one type, and some also have symptoms like constipation, diarrhea, or loss of taste and smell that don’t seem to fit neatly into one of the three groups.

One explanation for the different groups of symptoms is the lingering presence of the virus in specific tissues, where it presumably continues to reignite an inflammatory response.

For example, someone who has headaches or brain fog may have a virus that resides in their brain tissue, whereas someone with cardiovascular symptoms may have virus present in the heart, lungs or vasculature. And a chronically heightened immune response and widespread inflammation throughout the entire body may partially explain why so many – more than 50% of Long COVID sufferers---experience the devastating fatigue.

Read the rest of the article: the RECOVER study is looking for participants (anyone can join, even without LC) and will be testing treatments in coming months.

[anveshanblog]

Global Regenerative Medicine Market at  value of USD 70.11 billion

Forecasted for 2024 to 2028, the regenerative medicine sector is anticipated to surge to a valuation of USD 70.11 billion, soaring at a notable CAGR of 23.31% within the years 2023 to 2028. This growth trajectory is primarily propelled by the increasing prevalence of chronic diseases worldwide, necessitating groundbreaking therapies and remedies to effectively combat these enduring health conditions. As the demand for innovative treatments intensifies amidst the persistent challenge of chronic illnesses, various industries are compelled to invest in research and development efforts to meet the evolving healthcare needs of individuals.

Regenerative Medicine Market Forecast and Dimensions Influenced by factors such as platelet-rich plasma, TRIM72 protein, and advancements in vasculature development, the global regenerative medicine market is witnessing rapid expansion, bolstered by burgeoning research grants and the emergence of innovative pipeline candidates. Notably, cell therapy, particularly in domains like skeletal muscles and vasculature, is gaining prominence, with companies like CellPoint spearheading the development of novel cell therapy solutions.

Download Global Regenerative Medicine Market Sample PDF Report

Market Segmentation and Dynamics The regenerative medicine market is characterized by a dynamic landscape spanning various domains, including blood cancers, rare diseases, and chronic genetic disorders. Advancements in personalized medicine, gene therapy, and CRISPR therapy are driving transformative changes, with key players like Metcela Inc, Integra LifeSciences, and ACell, Inc leading the charge in developing innovative cellular therapies and tissue engineering solutions. Strategic initiatives such as mergers, research collaborations, and partnerships are further fostering the development of groundbreaking treatments like CAR-T treatment and gene therapy.

The market segmentation, comprising applications, technology, and geography, underscores a thriving ecosystem fueled by healthcare expenditure, governmental support, and a robust pipeline of innovative candidates across therapeutic areas.

Regional Contribution and Market Trends North America is poised to make a significant contribution to global market growth, with factors such as rising incidence of chronic and acute diseases, a rapidly aging populace, and heightened awareness of regenerative therapies driving expansion. In the APAC region, markets like Japan are shaping the global landscape, indicating a widespread acceptance and adoption of regenerative medicine.

Emerging Trends and Challenges The rising significance of CAR-T therapies and the increasing complexity of regenerative medicine products are notable trends and challenges shaping market dynamics. While CAR-T therapies demonstrate remarkable potential in targeting and eliminating cancer cells, the complexity of regenerative products, coupled with insufficient regulatory frameworks and reimbursement issues, poses significant hurdles to market growth.

Key Players and Market Analyst Overview Key companies such as AbbVie Inc., Amgen Inc., and Johnson and Johnson are implementing various strategies to enhance their market presence, including strategic alliances, mergers, and product launches. The market is witnessing continuous innovation, with a focus on addressing conditions like blood cancers, rare diseases, and chronic genetic disorders.

Segment Overview and Conclusion The regenerative medicine market research report provides comprehensive data and forecasts, highlighting the sector's growth potential and evolving dynamics across various segments. From advancements in personalized medicine to the exploration of gene-based therapy and stem cells, regenerative medicine continues to revolutionize healthcare, offering hope for addressing age-related disorders and enhancing patient outcomes across diverse therapeutic areas.

Download Global Regenerative Medicine Market Sample PDF Report

[usmedilife12health]

Does Orcibest increase heart rate?

Orcibest Tablet is a Tablet manufactured by ZYDUS CADILA.

It is commonly used for the diagnosis or treatment of Asthma, lung disorder , constriction of the air passages.

It has some side effects such as Abnormally rapid heart rate,Coughing,Chest pain,Bad taste.

Orcibest Tablet is a bronchodilator medicine that is used to relieve symptoms such as wheezing, shortness of breath, chest tightness, breathing difficulties, coughing, etc. caused by asthma and chronic obstructive pulmonary disease.

Orcibest 10mg tablet contains Orciprenaline as its active medicine. It is useful in treating patients with breathing difficulty due to the narrowing of airways (bronchus) as in asthma, infection of t

he lungs like in tuberculosis, sarcoidosis, allergic conditions like chronic bronchitis, silicosis and some cancerous conditions of the lungs.

Orcibest should be taken as directed by the doctor and in doses and duration as prescribed.

Do not take it more than that prescribed or for a prolonged duration.

What Are The Uses Of The Orcibest 10 Mg Tablet (Orciprenaline):

Orcibest 10 Mg Tablet is used in the treatment in following conditions:

Asthma

Chronic obstructive pulmonary disease

How Orcibest 10 Mg Tablet (Orciprenaline) Works:

Orcibest 10 Mg Tablet has an active ingredient; Orciprenaline is a bronchodilator which works by relaxing the muscles in the airways and widens airways. This makes breathing much easier.

Orciprenaline is a selective beta (2)-adrenergic agonist which stimulates receptors of the smooth muscle in the lungs, uterus, & vasculature supplying skeletal muscle, having minimal or no effect on alpha-adrenergic receptors.

The action of orciprenaline is mediated by cAMP, the production of which is increased by beta stimulation.

This drug is believed to act by activating adenylate cyclase, the enzyme liable for producing the cellular mediator cAMP.

What Should You Avoid While Taking Orcibest 10 Mg Tablet (Orciprenaline):

You should avoid taking alcohol  

You should avoid driving

You should avoid taking Medicines without prescriptions

When Not To Use Orcibest 10 Mg Tablet (Orciprenaline):

You should not take Orcibest 10 Mg Tablet if you:

Have ever noticed any Allergy/Hypersensitivity

Have liver problems

Have kidney problems

Are patient with Tachycardia

Have Hypertension

Have Hyperthyroidism

Have Hypokalemia

Have heart disease

Have Diabetes

Are pregnant

Have infections

Are breastfeeding

Dosage:

Orcibest 10 Mg Tablet contains an active ingredient, Orciprenaline, which is used in the treatment of asthma and chronic obstructive pulmonary disease.

This medicine is available in different substitutes & strengths & has got to be purchased or given on doctor’s prescription only.

You must consult your physician for adjustment of dosage & time of the medicine because age and severity of the disease differ from person to person and it can only be best judged by your doctor.

Adults are advised to take Orcibest 10 Mg Tablet at a fixed time with or without food as instructed by your Doctor.

You must take Orcibest 10 Mg Tablet regularly on time for better results.

How Much Of The Orcibest 10 Mg Tablet (Orciprenaline) to Be Used:

As Orcibest 10 Mg Tablet is available in various strengths and substitutes, Patients are always advised to follow their doctor’s prescriptions and instructions to take Orcibest 10 Mg Tablet.

You must not take the Tablet on your own & for longer period than recommended by doctor.

How To Take The Orcibest 10 Mg Tablet (Orciprenaline):

Take Orcibest 10 Mg Tablet in the dose and duration as advised by your doctor.

Take in the Tablet as a whole. You are suggested not to chew, crush or break the Tablet.

Orcibest 10 Mg Tablet is to be taken with or without food, but it is better to take it at a fixed time. 

For How Long Should You Continue Using Orcibest 10 Mg Tablet (Orciprenaline):

You are always advised to take Orcibest 10 Mg Tablet as prescribed.

Do not start/stop using this medicine yourself.

You must strictly follow all the directions given by your doctor.

You must not take the Tablet in larger or smaller quantity or for longer period than suggested by your doctor.

[adtiya01]

Navigating the Complexity: Unraveling the Role of Extracellular Vesicles in Cancer Progression

Introduction:

Cancer, a formidable adversary to human health, continues to be a major focus of research. In recent years, the spotlight has turned to a tiny yet powerful player in the intricate landscape of cancer progression—the extracellular vesicle. In this guide, we embark on a journey to understand the nuanced role of extracellular vesicles in driving cancer progression and the implications for cutting-edge clinical research.

Decoding Extracellular Vesicles:

Extracellular vesicles (EVs) are small, membrane-bound particles released by cells into the extracellular space. These vesicles carry a cargo of proteins, nucleic acids, and other bioactive molecules, serving as messengers that influence neighboring cells. In the context of cancer, the role of EVs is proving to be a fascinating area of exploration.

Key Functions of Extracellular Vesicles in Cancer Progression:

Cell-to-Cell Communication:Extracellular vesicles facilitate communication between cancer cells and their microenvironment. By shuttling molecular information, they can modulate the behavior of neighboring cells, promoting a pro-tumorigenic environment.

Tumor Microenvironment Remodeling:EVs play a crucial role in reshaping the tumor microenvironment. They can influence the surrounding tissues, vasculature, and immune cells, creating a supportive niche for cancer progression and metastasis.

The Role of Clinical Research Training:

Understanding the intricacies of EVs in cancer progression requires a strong foundation in clinical research. Enrolling in a Clinical Research Course equips researchers with the knowledge and skills needed to navigate the complexities of studying these tiny but influential vesicles. A Clinical Research Training Institute offering the Best Clinical Research Course provides a solid educational base for those delving into this cutting-edge field.

Significance in Cancer Diagnosis and Treatment:

Biomarker Discovery:Extracellular vesicles hold promise as potential biomarkers for cancer. Their cargo, reflective of the originating cancer cells, can be analyzed for diagnostic purposes, offering a non-invasive method for early detection.

Therapeutic Targeting:Understanding the role of EVs opens avenues for targeted therapies. By intercepting the communication mediated by these vesicles, researchers aim to disrupt the processes that contribute to cancer progression, offering new strategies for treatment.

Challenges and Ongoing Research:

Heterogeneity of EVs:The diverse nature of extracellular vesicles poses a challenge in standardizing research methodologies. Researchers are continually refining techniques to isolate and characterize specific subtypes of EVs for more accurate analyses.

Clinical Translation:Moving findings from the laboratory to clinical applications requires rigorous testing and validation. Clinical researchers play a vital role in bridging the gap between fundamental discoveries and practical applications for patient care.

Future Prospects:

The evolving understanding of extracellular vesicles in cancer progression is paving the way for innovative therapeutic strategies and diagnostic approaches. As technology and methodologies advance, professionals trained in clinical research are at the forefront of translating these discoveries into tangible benefits for cancer patients.

Conclusion:

In conclusion, extracellular vesicles are emerging as key players in the intricate dance of cancer progression. Professionals aspiring to contribute to this evolving field can benefit from enrolling in a Top Clinical Research Training program. By doing so, they position themselves to unravel the mysteries of EVs, contributing to the ongoing efforts to decode the language of these tiny messengers and, ultimately, devising novel approaches to combat cancer at its core. The role of extracellular vesicles in cancer progression represents both a challenge and an opportunity, beckoning researchers to explore new frontiers in the quest for effective cancer diagnosis and treatment.

[jcmarchi]

Aging Brain Initiative symposium showcases “cutting-edge” research across MIT

New Post has been published on https://thedigitalinsider.com/aging-brain-initiative-symposium-showcases-cutting-edge-research-across-mit/

Aging Brain Initiative symposium showcases “cutting-edge” research across MIT

Spanning computer science, mechanical engineering, biological engineering, neuroscience, and other disciplines, presenters at MIT’s Aging Brain Initiative Symposium Oct. 23 delivered a rich and diverse sampling of the university’s research to address a major global problem: neurodegenerative diseases such as Alzheimer’s and amyotrophic lateral sclerosis (ALS).

“We still don’t completely understand the mechanism underlying the process of aging. We do know that aging is associated with many health problems, particularly the chronic and progressive diseases of the brain known as neurodegenerative diseases,” said Picower Professor Li-Huei Tsai, founding director of the Aging Brain Initiative (ABI) and director of The Picower Institute for Learning and Memory. “So at MIT we have sought to encourage new thinking for the aging brain.”

Her remarks introduced the half-day symposium and poster session “Cutting Edge Approaches to Studying the Aging Brain” where hundreds of people gathered at Building 46 and online from 21 countries.

In 2015 Tsai and eight colleagues founded the ABI to engage scientists, engineers, and scholars across MIT to tackle the complex and multifaceted problems arising from age-related neurodegenerative diseases. In 2022 the ABI awarded seed grants to MIT faculty members to help them launch novel projects. Four of those professors provided updates on their work at the symposium, which also featured a keynote from University of Rochester professor Maiken Nedergaard, a pioneering neuroscientist who discovered the brain’s intrinsic “plumbing,” the “glymphatic system.”

Maiken Nedergaard takes questions from the audience moderated by symposium host Li-Huei Tsai.

Photo: David Orenstein/Picower Institute

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The system, which parallels the brain’s vasculature, washes cerebrospinal fluid through brain tissue, delivering nutrients and oxygen that cells need and carrying away waste. Since Nedergaard’s discovery in 2012, her and other labs have shown that the system is deeply relevant to brain health, including age-related neurodegenerative diseases. Glymphatic flow maintains healthy brain functions such as learning, and removes problematic proteins that are hallmarks of Alzheimer’s and Parkinson’s diseases (e.g. amyloid beta, hyperphosphorylated tau, and alpha synuclein). But the system starts to falter as people get older. Moreover, it is active during sleep, but patients with some neurodegenerative disorders sleep poorly, further reducing protein clearance.

“It’s clear that the brain has a major problem with waste clearance, because the diseases of aging, the neurodegenerative diseases, can all be regarded as diseases of a dirty brain,” Nedergaard said.

Nedergaard’s lab continues to characterize the glymphatic system and its role in brain health, including in how problems with fluid efflux from the system may contribute to brain swelling after traumatic brain injury (TBI). She noted that by old age, about half of people will have experienced at least one TBI.

Projects in progress

The complexity of neurodegenerative diseases, however, stems from myriad, multifaceted breakdowns with often-unknown root causes. Several MIT speakers described new work funded by ABI seed grants to understand the mechanisms that drive the progression of those pathologies.

Biochemist Peter Dedon, the Singapore Professor in the Department of Biological Engineering, offered the hypothesis that the pathology of amyloid plaques and tau protein fibrillary tangles in neurodegenerative diseases involves dysregulation of translating messenger RNA into proteins in neurons. Based on their discoveries in cancer and infectious disease, his research team is investigating how aberrant modifications of transfer RNA (tRNA) and silent mutations of codons, which are critical players in regulating the protein translation process, can cause excessive protein synthesis and protein precipitation. Using a mouse model known to produce unhealthy forms of the tau protein, Dedon’s lab is investigating tRNA reprogramming and codon-biased translation of mRNAs in brain tissue, seeking to determine whether these might explain why tau pathology increases sharply as mouse models reach an age threshold.

Play video

Peter Dedon at the MIT Aging Brain Initiative Symposium Video: Picower Institute

In her ABI-funded project, d’Arbeloff Career Development Assistant Professor of Mechanical Engineering Ritu Raman is investigating mechanisms underlying neurodegenerative diseases that impact mobility, such as ALS. Raman’s lab recently developed a tissue culture platform that simulates the mechanical effects of exercise at the cellular level and is developing co-cultures of muscles and neurons. Raman’s hypothesis is that while traditionally people consider the loss of motor function in ALS to be due to problems originating in the neurons, there may also be a benefit in understanding how communication from muscle affects neural growth, or retraction. In another recent study, for instance, she and colleagues showed that repeatedly inducing contraction in engineered muscle impacted cell signaling pathways related to nerve growth, making them more effective grafts in animal models.

Ritu Raman describes her work modeling the interactions between nerve and muscle tissues.

Photo: David Orenstein/Picower Institute

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Zooming out to the level of brain cells, circuits, and behavior, Institute Professor Ann Graybiel described her lab’s investigation of problems in a brain region called the striatum. She gave an example of work on Huntington’s disease, a neurodegenerative disease of aging. With Picower Institute investigator Myriam Heiman and Computer Science and Artificial Intelligence Lab member Manolis Kellis, Graybiel and research scientist Ayano Matsushima showed how gene vulnerabilities appear to undermine both movement and mood in the condition. In the Graybiel Lab’s new work, they are focusing on what she said is a third “M” that declines with age: motivation, or what we are familiar with as an engaged sense of “get up and go.” Graybiel described how the research is homing in on the brain circuits likely responsible for this disturbing effect of aging, including controllers of the neuromodulator dopamine and non-neuronal companion cells called astrocytes.

Improving care for people with brain aging diseases requires more than just improvements in understanding pathology and physiology. In his ABI-seeded work, electrical engineering and computer science associate professor Thomas Heldt, a member of the Institute for Medical Engineering and Science (IMES), teamed up with fellow EECS faculty professors Vivienne Sze and Charles Sodini to develop algorithms and software as powerful but unobtrusive ways to monitor patients’ neurocognitive state. Building on studies showing that eye responses exhibit changes in speed and accuracy amid aging and cognitive decline, Heldt’s lab is building a system that enables sophisticated eye tracking measures on common consumer devices such as iPads. These kinds of measures are often taken under carefully controlled lighting and motion conditions in a lab or clinical environment, but that severely limits opportunities for data collection. In their system, volunteers can use an app that asks them to simply glance to one side or another given a cue and measure their reaction time. The software is able to factor out different lighting or motion artifacts that would confound the measurements.

Play video

Thomas Heldt at the MIT Aging Brain Initiative Symposium. Video: Picower Institute

Plethora of posters

After the talks, in-person attendees spilled out of Building 46’s Singleton Auditorium into an atrium with 26 posters representing 15 MIT and affiliated labs. Postdocs and graduate students described research on topics ranging from brain imaging technologies and methods to studies of cell gene expression, epigenomics, proteomics or metabolomics in neurodegenerative diseases to potential therapeutics, such as gene therapies or sensory stimulation of key brain rhythms.

For example, the lab of chemical engineering associate professor Kwanghun Chung of the Picower Institute and IMES displayed three posters describing technologies for processing and imaging whole human brain samples, for instance to analyze Alzheimer’s pathology in postmortem brains. Five members of biological engineering professor Ernest Fraenkel’s lab presented posters describing methods and models for analyzing the “multi-omics” of diseases including ALS, Huntington’s, and Alzheimer’s.

From the podium to the posters, the afternoon served to showcase the wide-ranging interest across MIT in research to better understand and address diseases of the aging brain.

[marketsizereports]

Emerging Technologies and Innovations in the North America Aortic and Vascular Graft Procedures Market

The North America Aortic and Vascular Graft Procedures market has been witnessing significant advancements in technology and innovation. These emerging technologies are aimed at improving patient outcomes, reducing complications, and enhancing the overall efficacy of aortic and vascular graft procedures. Here are some notable innovations in this field:

Endovascular Aneurysm Repair (EVAR): EVAR is a minimally invasive procedure used to treat abdominal aortic aneurysms (AAAs). It involves the placement of a stent graft within the aorta to reinforce the weakened vessel walls and prevent aneurysm rupture. EVAR has gained popularity due to its reduced invasiveness, shorter recovery times, and lower mortality rates compared to open surgical repair.

Fenestrated and Branched Endovascular Aortic Repair (FEVAR and BEVAR): FEVAR and BEVAR are advanced techniques used to treat complex aortic aneurysms that involve the renal arteries or other branch vessels. These procedures utilize custom-made stent grafts with fenestrations or branches that align with the patient's specific anatomy, allowing for precise deployment and preservation of blood flow to vital organs.

Bioactive and Biodegradable Grafts: Bioactive grafts are designed to stimulate tissue regeneration and promote healing. They may incorporate growth factors or coatings that encourage the body's natural healing processes, leading to better integration of the graft and reduced risk of complications. Biodegradable grafts are gradually absorbed by the body over time, eliminating the need for long-term implant presence and potentially reducing the risk of infection or graft-related complications.

3D Printing and Patient-Specific Grafts: 3D printing technology enables the creation of patient-specific grafts tailored to individual anatomical requirements. This customization improves the accuracy of graft placement and ensures optimal fit and functionality. Patient-specific grafts can be designed to match complex anatomies, making them particularly useful in treating aortic aneurysms with challenging geometries.

Advanced Imaging Techniques: High-resolution imaging techniques such as computed tomography angiography (CTA) and magnetic resonance angiography (MRA) play a crucial role in the diagnosis, planning, and post-operative evaluation of aortic and vascular graft procedures. These imaging modalities provide detailed visualization of the vasculature, aiding in precise graft sizing, placement, and surveillance.

Robotic-Assisted Surgery: Robotic-assisted surgical systems offer enhanced precision and dexterity to surgeons performing aortic and vascular graft procedures. These systems allow for smaller incisions, improved visualization, and greater maneuverability of surgical instruments. Robotic-assisted surgery can contribute to reduced trauma, faster recovery, and improved patient outcomes.

Nanotechnology: Nanotechnology has the potential to revolutionize aortic and vascular graft procedures. Nanomaterials, such as carbon nanotubes and nanofibers, can be incorporated into grafts to enhance their mechanical properties, promote cellular adhesion, and provide controlled drug release for targeted therapies. Nanotechnology-based approaches may lead to improved graft durability, reduced complications, and enhanced tissue regeneration.

For more insights on the North America Aortic and Vascular Graft Procedures market category analysis, download a free report sample

These emerging technologies and innovations in the North America Aortic and Vascular Graft Procedures market are driving advancements in the field, offering new treatment options, improving patient outcomes, and shaping the future of vascular surgery. Continued research and development in these areas hold the potential to further enhance the safety, efficacy, and long-term success of aortic and vascular graft procedures.

[leedsomics]

Single-cell transcriptomics of adult skin VE-cadherin expressing lineages during hair cycle

Adult skin homeostasis involves global reorganization of dermal lineages at different stages of the mouse hair growth cycle. Vascular endothelial cadherin (VE-cadherin encoded by Cdh5) expressing cells from blood and lymphatic vasculature structures are known to remodel during the adult hair cycle. Here we employ single-cell RNA-sequencing (scRNA-seq) 10x-genomics analysis of FACS-sorted VE-cadherin expressing cells marked via Cdh5-CreER genetic labeling at resting (telogen) and growth (anagen) stage of hair cycle. Our comparative analysis between the two stages uncovers a persistent Ki67+ proliferative EC population and documents changes in EC population distribution and gene expression. Global gene expression changes in all the analyzed populations revealed bioenergetic metabolic changes that may drive vascular remodeling during HF growth phase, alongside a few highly restricted cluster-specific gene expression differences. This study uncovers active cellular and molecular dynamics of adult skin endothelial lineages during hair cycle that may have broad implications in adult tissue regeneration and for understanding vascular disease. http://dlvr.it/SlSNpF

[twnpkdinhighschool]

Meditations on the Mess

Originally posted on my substack, which occasionally includes my personal ramblings

I want to be a different kind of person than the one I turned out to be. I want the things I do and the way I live to make sense, to be congruent with my values, preferences, and ideal aesthetic.

I want to be neat, not too neat, just functionally, reasonably situated. My things as tools, items at hand for me to manipulate, not as an artificial environment that I live in, fabricated to distract and entertain me like a hamster in its cage.

I want to feel pretty, and I think deep down, I won’t ever feel pretty in a stable and mature way until my home does as well.

But cleaning up won’t do it anymore. I don’t live in mess, I live in squalor; the walls need to be scrubbed, scoured. The floors are overgrown with roots, the vines creeping up kitchen counters and bedside tables.

I seem to infect, inhabit, and corrupt my spaces, a symbiote, a mass with vasculature, a cancer too insidious to ever get good margins on. I’m in its bones.

This place has been animated while my body becomes superfluous, reduced to a mere go-bag of blood and body fat, my own veins acting as an IV; to leave my house feels dissociative, like I’m astral projecting into the CVS drive thru.

During the winter, when the snow is fresh and the roads not yet plowed, the host succumbs, the possessor asleep inside as muscles atrophy and open sores fester and rot and gangrene. The filth does not hibernate, only its witness. As the frost turns to dew, mummified bodies and detritus show themselves.

Extended metaphor is the tool of cowards and revisionists: my home looks like shit.

[sk270114]

Varicose vein surgery: The best tips for faster recovery include:

Rest

Take it very easy for at least 7 days

Increase activity level slowly

Don’t rush into exercise after the surgery. Take it slow to make sure that incisions don’t open up and that blood flow returns to normal

Bathing is a no-no

No showering or bathing, at all, for at least two days after the surgery. You can take a sponge bath, as long as you avoid the incisions

Eat a fiber-rich diet after your procedure ao that your bowel movements will return to normal sooner.

Ice application can go a long way in reducing pain, swelling, and bruising. Apply ice pack to your incisions for 10-20 minutes every 2-3 hours

Elevate your legs to keep the blood flowing to your heart by taking the pressure off of your veins and allowing them to heal faster

Sleep properly and use home remedies, over-the-counter drugs, and prescription medications for a sound sleep.

The pain gets worse before getting better. Most people say that the pain of vein surgery peaks on days 8-10 and then gets better. By day 14, your pain should be minimal

Expect Bruising

Bruising after vein surgery is common

Eat what you want

Wear the compression stockings. Do your best to wear these stockings for at least two weeks after your surgery

Walk for 10 minutes every day

Check your incisions at least once every day to look for redness, swelling, pus, and other signs of infection

Depressurize

Do not sit or stand for too long in the first 1-2 months after your surgery. Keep your legs elevated to promote healing and give your vasculature time to reestablish blood flow

Time off

Don’t drive

Be patient

There are many hospitals in Chennai where varicose vein surgery is done with great success.

[drpriya]

Varicose vein surgery - Best tips for faster recovery-

Rest

You need to take it very easy for at least 7 days.

Increase Activity Slowly

Don’t rush into exercise after your surgery. Take it slow to make sure that incisions don’t open up and that blood flow returns to normal.

Bathing Is a No-No

There is no showering or bathing, at all, for at least two days after your surgery. You can take a sponge bath, as long as you avoid the incisions.

Eat Fiber

Surgery can affect your bowel function. If you eat a high-fiber diet right after your procedure, your bowel movements will return to normal sooner.

Ice It

Ice can go a long way to reducing pain, swelling, and bruising. Ice your incisions for 10-20 minutes every 2-3 hours.

Elevate Your Legs

Keep the blood flowing to your heart by keeping your legs elevated. This takes pressure off of your veins and allows them to heal faster.

Sleep proper

Sleeping can be tough right after vein surgery. Talk to your doctor about home remedies, over-the-counter drugs, and prescription medications for sleep.

The Pain Gets Worse Before Getting Better

Most people say that the pain of vein surgery peaks on days 8-10 and then gets better. By day 14, your pain should be minimal.

Expect Bruising

Bruising after vein surgery is common.

Eat What You Want

Wear the Compression Stockings

Do your best to wear these stockings for at least two weeks after your surgery.

Walk for 10 Minutes Every Day

Check Your Incisions

Check your incisions at least once every day to look for redness, swelling, pus, and other signs of infection.

Depressurize

Don’t sit or stand for too long in the first 1-2 months after your surgery. Keep your legs elevated to promote healing and give your vasculature time to reestablish blood flow.

Time Off

Don’t Drive

Be Patient

There are many hospitals in Chennai where varicose vein surgery is done with great success.

[drforambhuta]

Varicose vein surgery: The best tips for faster recovery include:

Rest

Take it very easy for at least 7 days

Increase activity level slowly

Don’t rush into exercise after the surgery. Take it slow to make sure that incisions don’t open up and that blood flow returns to normal

Bathing is a no-no

No showering or bathing, at all, for at least two days after the surgery. You can take a sponge bath, as long as you avoid the incisions

Eat a fiber-rich diet after your procedure ao that your bowel movements will return to normal sooner.

Ice application can go a long way in reducing pain, swelling, and bruising. Apply ice pack to your incisions for 10-20 minutes every 2-3 hours

Elevate your legs to keep the blood flowing to your heart by taking the pressure off of your veins and allowing them to heal faster

Sleep properly and use home remedies, over-the-counter drugs, and prescription medications for a sound sleep.

The pain gets worse before getting better. Most people say that the pain of vein surgery peaks on days 8-10 and then gets better. By day 14, your pain should be minimal

Expect Bruising

Bruising after vein surgery is common

Eat what you want

Wear the compression stockings. Do your best to wear these stockings for at least two weeks after your surgery

Walk for 10 minutes every day

Check your incisions at least once every day to look for redness, swelling, pus, and other signs of infection

Depressurize

Do not sit or stand for too long in the first 1-2 months after your surgery. Keep your legs elevated to promote healing and give your vasculature time to reestablish blood flow

Time off

Don’t drive

Be patient

There are many hospitals in Chennai where varicose vein surgery is done with great success.

[ayushaktiayurveda]

Rescue Yourself From Liver Cirrhosis

Cirrhosis indicates scarring from liver diseases and different reasons for liver damage, such as alcohol abuse disorder. Cystic fibrosis and syphilis may also prompt liver damage and cirrhosis in the long run — although these two causes are substantially less common.

Your liver can recover because of damage, yet this cycle typically advances scar tissue. The more scar tissue that creates, the harder it is for your liver to work appropriately.

Cirrhosis is an advanced phase of liver fibrosis that is joined by mutilation of the hepatic vasculature.

It is an ever-evolving infection, growing gradually over numerous years. If it is permitted to proceed, the buildup of scar tissue can eventually stop liver capability. For cirrhosis to develop, long-term, continuous liver damage must happen.

Scarring weakens the liver's capacity to:

control diseases,

eliminate microbes and toxins from the blood,

process nutrients, hormones, and medications,

cause proteins that control blood thickening, and

produce bile to assist with retaining fats, including cholesterol and fat-dissolvable nutrients

A healthy liver can recover the greater part of its own cells when they become harmed. With end-stage cirrhosis, the liver can never again successfully supplant harmed cells. A healthy liver is essential for survival.

Cirrhosis is the twelfth driving reason for death by infection, representing 27,000 deaths yearly. The condition influences men somewhat more frequently than women.

FOR MORE INFO VISIT - https://ayushakti.com/symptoms-and-illness/type/rescue-yourself-from-liver-cirrhosis

[justspiltink]

What if I get to spend the rest of my life counting the sun spots that grace your shoulders with each summer game to pause with every winter and watch with warm coffee in my hands them hide amongst your melanin freckles waiting to present themselves on your next summer day What if I get to spend the rest of my life trailing my fingers through the valley of your inner arm a cartographer of your vasculature driving between your shiver and warmth the rest of my life, could I hear the soft protesting huffs of your lungs as you drift in and out of a deep sleep smell the shampoo from your rarely peppered hair feel the graze of the bridge of your nose against mine steal glances of your hazel eyes to meet you again I could grasp those resilient shoulders to let you know how it is that I know that I love you you need not be resilient with me, unless you need to. I am here for your breaking for your careful keeping for your gentle embrace for your love and your peace. - love and peace, 2022

[medi-techinsights]

Global Interventional Cardiology Devices Market is projected to witness a decent growth rate of 2 to 3% by 2026

Interventional cardiology is a branch of cardiology that utilizes nonsurgical, catheter-based treatments for structural heart diseases. It utilizes devices such as catheters & sheaths, guidewires, balloons, stents, vascular closure devices, atherectomy devices, intravascular ultrasound (IVUS), and other devices to repair narrowed arteries, damaged or weakened blood vessels, heart valve disorders, and congenital heart diseases.

Rising prevalence of cardiovascular diseases & hypertension, a higher degree of unmet clinical needs, and rising affluence are creating ample opportunities for the interventional cardiology devices market in the APAC region. The growth of the interventional cardiology devices market in the APAC is likely to be driven by China and India.

Technological Innovations Drives the Interventional Cardiology Devices Market Growth

The global interventional cardiology devices market is a technology-driven market and is marked by product innovations. For instance,

In May, 2022, Medtronic received U.S. FDA approval for the Onyx Frontier™ drug-eluting stent (DES). The Onyx Frontier DES is used for the treatment of patients with coronary artery disease (CAD). It offers an innovative delivery system and builds upon the acute performance and clinical data from the Resolute Onyx™ drug-eluting stent.

In April 2022, Translumina launched VIVO ISAR, its latest generation dual drug polymer-free coated stent (DDCS), in various international markets including Europe.

Growth Strategies Adopted by Market Players to Establish Their Foothold in Interventional Cardiology Devices Market

The global interventional cardiology devices market is marked by the presence of both established and emerging players. Players operating in this market have adopted both organic and inorganic growth strategies such as acquisitions, and new product launches to garner higher market share. For instance,

In April 2022, Transit Scientific announced the FDA clearance of its XO Cross® Support Catheter Platform to include coronary use. The platform is indicated to guide and support a guidewire during access of the peripheral or coronary vasculature, allow for wire exchanges, and provide a conduit for delivery of saline solutions or diagnostic contrast agents.

The interventional cardiology devices market is expected to grow in the upcoming years due to increasing cardiovascular cases, emerging growth opportunities in the APAC region, technological advancements in interventional cardiology devices, and favourable reimbursement in key markets.

Competitive Landscape Analysis: Interventional Cardiology Devices Market

The market is marked by the presence of key market players such as Medtronic, Boston Scientific, Abbott, Medinol, Biotronik, SMT, Terumo, Lepu Medical, Microport, among others.

Get Customized Report on Interventional Cardiology Devices Market @ https://meditechinsights.com/interventional-cardiology-devices-market/

[congoway2]

Your Tubulin Inhibitor VERU-111 along with Dupracetam Offers an Efficient Treatments for Vemurafenib-Resistant A375 Cancer malignancy

Trademark (H) The year 2013 Azines. Karger AG, BaselQualifications: The magnitude Nine.2 earthquake arranged away from asian The japanese within 03 2011. Numerous children happen to be moving into short-term houses furnished by the neighborhood authorities given that they misplaced their houses due to the great tsunami (tsunami class) or the anticipated high-dose light resulting from the particular atomic crash with the Fukushima Daiichi Fischer Electrical power Grow (rays party). Your tsunami has been a lot more than In search of michael high in Soma, Fukushima, that is situated 30 kilometers n . #Link# from the Fukushima Daiichi Nuclear Electrical power Place as well as alongside the mandatory evacuation location. A fitness screening process plan occured for that evacuees inside Soma throughout September 2011. The aim of these studies ended up being assess the metabolic single profiles of the evacuees both before and after your devastation. Many of us hypothesized how the evacuees would expertise worsened metabolism status depending on previous reports regarding earthquakes. Methods: Info upon 190 subjects whom joined a health screening program in September or even October regarding The year 2010 (pre-quake) and also 2011 (post-quake) have been retrospectively analyzed along with one of them review. Pre-quake as well as post-quake link between physical tests and also clinical tests have been in comparison in the tsunami as well as light organizations. Any multivariate regression design was used to find out pre-quake predictive factors for elevation of hemoglobin A1c (HbA1c) inside the tsunami party. Results: Considerably greater values associated with body weight, bmi, waist circumference, and also HbA1c and lower high-density lipoprotein levels of cholesterol put together at the post-quake verification in comparison with the particular pre-quake quantities (s Is equal to 3.004, p Equals Zero.Drive, p Equates to Zero.008, g < 2.001, and also s Equates to 2.Drive, respectively). An extremely larger percentage regarding subject matter from the tsunami team with higher HbA1c, thought as >Is equal to 5.7%, ended up being observed following your quake (24.3%) than before your quake (Fourteen.8%) (r < 0 #Link# .001). Regional factors, intermittent hospital trips, along with waistline area prior to earth quake were defined as predictive factors about multivariate analysis #Link# to the degeneration of HbA1c. Conclusions: Post-quake metabolic variables had been reduced in contrast to pre-quake base line levels inside children have been surviving in non permanent homes. An organic disaster may affect metabolic users, and also careful follow-up pertaining to children should be designed.Biomineralization in pathological extraosseous web sites (i.at the. vasculature and also gentle flesh) is assigned to improved deaths along with death. So-called 'nanobacteria' happen to be referred to as pathogenic agents causing a lot of ailments including calcification. Initially, their looks, and achieving a articles comprising nucleic chemicals in addition protein as well as qualities of growing structures, proposed that they were existing microorganisms. However, it could be revealed that the so-called nanobacteria have been actually mineralizing nanoparticles that contain mineral and also non-mineral compounds, the particles bind in order to recharged molecules and that supersaturation permits within vitro increase of these types of nanoparticles. The latest info show in which nanoparticles composed of protein-mineral things can be viewed both in vitro along with vivo as precursors regarding matrix calcification.

[scriptmedic]

The Writer's Guide to Blood Donation Part 1: Typical Donation

Content Warning: This post contains numerous references to needles and blood.

Sometimes in our stories, our characters are going to need to give blood. Whether it’s to help an injured family member or a wounded comrade, one of the ways your characters can show their heroism is by giving of themselves, their literal lifeblood, to help another.

Blood donation can also be a way to “save the cat,” a positive act that demonstrates that our character is a kind, compassionate person that the reader should like.

There are two types of blood donation that I’m going to talk about. This post will discuss a typical blood donation, where the character’s blood is tested, a set quantity is drawn off, and the blood is banked. This can be a directed donation for a specific person, typically done in a hospital, or an undirected donation in which a character donates blood for a bank to use later, which is likely to be done at a blood drive.

The second post, which we’ll talk about in the near future, is a person-to-person transfusion, in which one character’s vein is linked to another’s. This is a far more dangerous scenario which is only done in emergencies in an austere environment where  hospitals, and blood banks, are not an option.

What Are the Minimum Standards for Donation?

To donate blood, a character must….

Weigh at least 110 lbs (50kg)

Be at least 17 years of age

Have not donated whole blood in the last 56 days (8 weeks)

Be feeling well and healthy

Not be taking antibiotics, aspirin related products, or blood thinners

Not be a male who has had sex with another male in the last year. (The American Red Cross and FDA advocate that gender is self-identified; the ARC has a whole page about LGBT donors located here.)

Full eligibility requirements for the American Red Cross are found here.

What’s the Process Like?

The process for a typical blood donation looks like this:

The character registers with an intake person. Often they’re offered a “gimme” as an incentive to sign up and donate, such as lip balm or a small book. They’re given a ticket (or have a donor card), which is scanned by a barcode reader.

They answer a very, very detailed questionnaire, which asks everything from their height and weight, whether a male character has had sex with other men ever, which countries they’ve visited in what timeframe, or whether they’ve ever had a graft of their meninges. These days this is done on a tablet.

The donor will then wait to see an intake nurse, who performs a few checks. They get their blood pressure taken, their pulse taken, and a fingerstick is performed to check the blood’s concentration (hematocrit).

The donor will then wait to actually go and donate. When they go in, the nurse taking the blood will ask which arm the donor prefers; usually donors prefer their non-dominant arm.

The donor will lie down on a cot. The nurse will prepare the supplies, affix pre-printed labels to the bags, and check the character’s name and date of birth.

The nurse will place a blood pressure cuff on the arm above the selected donation site, which is usually the bend of the elbow, and partially inflate the cuff. The character will be given something to squeeze; a rubber or foam stress ball or a roll wrapped in paper is typical.

The nurse will insert the needle into the vein, hopefully on the first attempt and hopefully without “fishing.” The needle is fairly large, a 16ga (the smallest IV needle in common use is a 24ga, the largest is a 14ga). and is taped into position. The entry site will be covered with a small piece of gauze and taped down.

The blood is first sent into a series of tubes for testing. After the vials are drawn, the blood goes down one tube into a small pouch, which is where it’s available to draw from in the blood bank to test for compatibility with recipient blood. After that, blood begins to fill the actual donation bag, which is 500mL in size (or about a pint). During this process the character will be encouraged to squeeze their fist every 5-10 seconds to help improve blood flow.

Blood donation is timed, for reasons I’m not quite sure of. A healthy donor with good vasculature might complete their donation in about 5-6 minutes, while someone with worse veins might complete theirs in 8-10 minutes.

Once the donation is complete, the nurse will clamp off the line, retract the needle, and ask the donor to put pressure on the gauze over their insertion site. The nurse will then get a piece of stretchy, self-stick material known in the biz by its original trade name Vetrap, and roll it around the insertion site. The bandage sticks to itself, theoretically not to skin, and can come in a number of colors; on my last donation, it was teal.

The character will be instructed not to bend over or lift heavy objects for at least 2 hours, to not remove the Vetrap for at least 6 hours, and to increase fluid intake over the next 2 days to compensate for the lost blood volume. They’ll be allowed to lie still if the character feels faint, or sent to sit for a few minutes and recover if they feel well enough to walk. Most donation sites offer juice, water, and snacks — especially cookies — to help restore fluid volume and sugar to the bloodstream.

How Does Blood Donation Feel?

This will vary from donor to donor. Genetic males, and those with larger bodies, typically have a slightly higher blood volume than genetic females, and thus tend to tolerate significant blood loss (such as donation) better, but the effects of donation can be felt by anyone.

It’s very common for donor characters to feel dizzy, lightheaded, or nauseous after a donation. Headaches are quite frequent, and the donor might feel a need to sit down for a prolonged period after the fact. The  character might simply feel fine after donation.

Remember that this is fiction, so the effects you choose are up to you. Sometimes the effects are felt more severely the next day than the day of the donation.

It’s common for the needle site to bruise significantly, particularly if the vein was small or the nurse was inexperienced and had to “fish” for a vein. This will start almost immediately after donation and will continue to worsen for an hour or two, then will fade over several days to a week.

So that’s a pretty standard blood donation! Next time in Part 2 we’ll discuss how donor-to-recipient, or direct transfusion works, and how your characters can make it work in dire circumstances!

xoxo, Aunt Scripty

[disclaimer]

[Maim Your Characters: How Injuries Work in Fiction is out! Click here to download a 100-page sample of the book.]

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The Writer’s Guide to Blood Donation Part 1: Typical Donation was originally published on ScriptMedicBlog.com