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sofiacarsonusa · 6 months

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Rejuvenate Your Health: IV Nutrition Therapy for Long-Term COVID Effects

In the wake of the COVID-19 pandemic, the world has faced unprecedented challenges, both in terms of public health and individual well-being. While much attention has been focused on the acute symptoms and immediate effects of the virus, there is a growing recognition of the long-term impact it can have on health, even after recovery. Many individuals continue to experience lingering symptoms, commonly referred to as "long COVID," which can include fatigue, brain fog, muscle weakness, and more. As we navigate through this new medical landscape, exploring innovative treatments becomes crucial, and one promising avenue is IV nutrition therapy.

Understanding Long-Term COVID Effects

Long COVID, also known as post-acute sequelae of SARS-CoV-2 infection (PASC), presents a complex array of symptoms that can persist for weeks or even months after the acute phase of the illness has passed. While the exact mechanisms behind these lingering symptoms are still under investigation, it is believed that a combination of factors, including immune dysregulation, inflammation, and tissue damage, may play a role.

Common symptoms of long COVID can vary widely among individuals but often include:

Persistent fatigue

Cognitive dysfunction (brain fog)

Shortness of breath

Muscle weakness and joint pain

Sleep disturbances

Anxiety and depression

These symptoms can significantly impact quality of life, making it challenging for individuals to resume their normal activities and function optimally in their daily lives.

The Role of IV Nutrition Therapy

IV nutrition therapy, also known as intravenous micronutrient therapy or vitamin IV therapy, involves the administration of vitamins, minerals, antioxidants, and other nutrients directly into the bloodstream via an intravenous infusion. This delivery method allows for maximum absorption and bypasses the digestive system, ensuring that nutrients are readily available for cellular use.

For individuals struggling with the long-term effects of COVID-19, IV nutrition therapy offers several potential benefits:

Replenishing Nutrient Deficiencies: Illness, stress, and poor dietary habits can deplete the body's stores of essential nutrients, exacerbating symptoms and impairing recovery. IV nutrition therapy can help replenish these deficiencies more efficiently than oral supplements, providing a boost to overall health and well-being.

Supporting Immune Function: A robust immune system is essential for fighting off infections and promoting healing. IV therapy can deliver high doses of immune-boosting vitamins such as vitamin C, zinc, and glutathione, helping to strengthen the body's defenses against recurring illness and inflammation.

Reducing Inflammation: Chronic inflammation is a hallmark feature of many long COVID symptoms and can contribute to tissue damage and persistent discomfort. Certain nutrients, such as vitamin C and omega-3 fatty acids, possess powerful anti-inflammatory properties and can help alleviate inflammation throughout the body.

Improving Energy Levels and Mental Clarity: Fatigue and cognitive dysfunction are common complaints among long COVID patients. IV therapy can provide a rapid infusion of energizing nutrients like B vitamins and magnesium, helping to boost energy levels, enhance mental clarity, and combat brain fog.

Promoting Tissue Repair and Recovery: The body requires an adequate supply of nutrients to repair damaged tissues and support the regeneration of cells. IV therapy can deliver essential building blocks such as amino acids, collagen, and vitamins A and E, facilitating the healing process and promoting faster recovery from illness.

Integrating IV Nutrition Therapy into Long COVID Management

While IV nutrition therapy shows promise as a supportive treatment for long-term COVID effects, it is essential to approach its use as part of a comprehensive care plan tailored to the individual needs of each patient. This may include:

Comprehensive Medical Evaluation: Before initiating IV therapy, patients should undergo a thorough medical assessment to evaluate their overall health status, identify specific nutrient deficiencies, and determine the most appropriate treatment approach.

Collaborative Care Team: Long COVID management often requires a multidisciplinary approach involving various healthcare professionals, including primary care physicians, specialists, nutritionists, and integrative medicine practitioners. Working collaboratively, these experts can develop a personalized treatment strategy that addresses the unique needs of each patient.

Lifestyle Modifications: In addition to IV therapy, patients may benefit from making lifestyle modifications to support their recovery, such as adopting a nutritious diet, engaging in regular exercise, managing stress levels, and prioritizing adequate sleep.

Regular Monitoring and Follow-Up: Monitoring patients' progress and adjusting treatment as needed is essential for optimizing outcomes and ensuring safety. Regular follow-up appointments allow healthcare providers to track changes in symptoms, assess the effectiveness of therapy, and make any necessary adjustments to the treatment plan.

Conclusion

As we continue to grapple with the long-term consequences of the COVID-19 pandemic, exploring innovative approaches to treatment is paramount. IV nutrition therapy offers a promising avenue for addressing the persistent symptoms associated with long COVID, providing essential nutrients directly to the body's cells and supporting overall health and well-being. By integrating IV therapy into a comprehensive care plan tailored to each patient's needs, healthcare providers can help individuals reclaim their vitality and rejuvenate their health in the face of ongoing challenges.

At Patients Medical, we recognize the importance of holistic and personalized care in managing long-term COVID effects. Our team of experienced healthcare professionals is committed to providing comprehensive support and innovative treatment options to help patients navigate their recovery journey with confidence and resilience.

If you or a loved one is struggling with the lingering symptoms of COVID-19, contact us today to learn more about how IV nutrition therapy and integrative medicine can support your path to healing and wellness.

#covid 19 #iv nutrition therapy #patients medical #holistic doctor #iv nutrition therapy for covid long haulers

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continualg · 5 years

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Generally, there are two situations where you might not have enough glutathione. These are termed acute and chronic glutathione depletion

#Acute Glutathone Depletion #Chronic Glutathione Depletion #acute and chronic glutathione depletion

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amberwellnessgroup · 4 years

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Can Glutathione Help You Recover From Mold Exposure?

We love our Pacific Northwest climate, beauty, and greenery. Unfortunately living in the Pacific Northwest can mean a higher risk of mold exposure. Because of our frequently rainy weather and moderate temperatures for such a big part of the year, it’s no surprise that the warm, dark, moisture loving fungi tend to thrive here. It’s a common complaint from patients to hear that there’s black spots in their bathrooms, basements, and windows. While this can be a very complex situation to deal with, we’re including some tips and tricks below for you to consider.

The fall can be an especially triggering time of year because of wet rotting leaves, forced air circulating mycotoxins in your home, and the presence of seasonal allergens like ragweed. Additionally, when the weather changes and we spend more time indoors we accumulate all of these exposures and put an extra load on the immune system. If you are already depleted, you will likely feel worse if you are living with an ongoing mold exposure.

One thing that happens when there has been an ongoing mold exposure such as living or working in a water damaged building, is the reservoir of mycotoxins (mold toxins) that accumulates in the body. Mycotoxins can cause all kinds of issues. One of the biggest problems, it depletes your glutathione! Glutathione is an antioxidant compound that is synthesized in your liver detoxification cycles. See our Detox 101 article in our January newsletter where we discuss glutathione and detoxification.

The good news is that you can supplement glutathione. It is important to get a liposomal form of glutathione so that it is absorbed and is able to be utilized within your body. We have four options in our clinic that we recommend, if you’d like the options emailed make a Fullscript account here and email Michelle to have the protocol shared with you. Since every living cell loves and needs glutathione, including the ones in the digestive tract, you need to have the liposomal version to get into the bloodstream and help you squelch the toxins from your acute and chronic mold exposure. The two sided benefit of replacing glutathione, is that you’ll be supporting your detoxification pathways and helping your body get rid of those stored mycotoxins.

Some simple practices in the kitchen to avoid, if you are feeling increased fatigue, allergy symptoms, or extra sensitive:

Fruit or veggies with brown spots (this is mold in the making, even cutting it off does not get rid of it all).

Leftovers that are more than 24 hours old will start creating more spores on the food and can increase your overall load.

High histamine foods Fermented foods Cured meats Pickled foods

If you are concerned about mycotoxins and mold exposures, this is the test that we can order in our clinic through Great Plains Laboratory. It is a kit that you take home and collect a urine sample, easy as that. If you are curious how mold is impacting your health, schedule a visit with either of our doctors today!

Learn more - Home - Amber Wellness Group

#womens wellness care #men's wellness care #women wellness #children wellness care #Cancer Therapy

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vitamininfusiontherapy · 4 years

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VITAMIN DRIP THERAPY, A HELP FOR HYDRATION AND CHRONIC HEADACHES?

Vitamin leaks-- Hollywood A-list celebs, professional athletes, and also even hectic mothers are going crazy about this brand-new pattern, which assures a fast power boost, countless benefits to the health system, and also relief from chronic migraine headaches.

The intravenous strategy is meant to deliver a greater pureness and focus of vital nutrients than what may be attained through diet regimen alone. In this post, we check out the background as well as technique of using vitamin drips to treat migraines, in addition to several of the clinical evidence presently offered.

WHAT'S IN A DRIP?

What lots of enthusiasts do not realize is that vitamin drips themselves are not a current creation.

As a matter of fact, the benefits of taking nutrients intravenously have actually been talked about considering that the 1950's, when a now-famous clinical leader named John Myers, M.D. created a preparation called the "Hydration therapyl" for the therapy of a wide variety of scientific conditions, varying from migraines as well as migraines to sinusitis and also heart disease.

However, Dr. Myers never ever made a note of the ingredients or concentrations of his secret mixture prior to diing in 1984. However, the initial prep work is believed to have contained magnesium chloride, vitamin C, vitamin B-series, calcium gluconate, thiamine and also thinned down hydrochloric acid.

After Dr. Myers passed, one more medical professional took control of his technique. Alan Gaby, M.D. modified the Hydration therapy dish to raise the degrees of magnesium chloride as well as vitamin C, eliminating the hydrochloric acid and keeping the vitamin B-series (sans folic acid), calcium gluconate, as well as thiamine.

Dr. Gaby found proceeded success in dealing with the late Dr. Myers' people with this brand-new vitamin drip formula, which he has offered at more than 20 medical conferences considering that the mid-eighties.

WHY INTRAVENOUS?

According to the National Institutes of Health and wellness, intravenous or mixture treatment has quantifiable distribution advantages over various other kinds of vitamin and mineral administration.

Of these, among the most noteworthy is the ability to promptly achieve adequate blood product degrees (concentration of the important minerals and also vitamins) in the blood stream, triggering the vitamin drip's healing may benefits.

Via this process the vitamins and minerals are supplied straight into the blood in their purest form, unaltered by the processes that would certainly be called for to break them down if they were ingested.

FULFILL THE CONTEMPORARY VITAMIN DRIP

Today, vitamin drips are carried out in similar way as they were in Myers' years. Some facilities will certainly utilize a typical IV drip, while others will utilize a needle only for insertion functions and afterwards remove it, allowing the catheter itself to supply the vitamins right into the blood stream.

One intravenous distribution approach is not far good than another below, but is more an issue of company choice. What may seemingly make a distinction is the actual cocktail you choose-- many vitamin, mineral, as well as nutrient solutions choices exist, each supplying various wellness advantages.

These may benefits might consist of reduction of stress and anxiety, enhanced rest, anti-aging, health system enhancing, detoxing and cleansing, weight-loss, mind health and wellness, discomfort reduction, and also allergy signs and symptom alleviation. In some clinics, people may even work with their supplier as well as personalize the drip dish to their own medical needs as well as aesthetic problems.

TREATING HEADACHES As Well As MIGRAINES WITH VITAMINS

There is unscientific proof of Dr. Myers as well as Dr. Gaby's recipes being utilized productively for managing with frustrations and also migraines, as several individuals will certainly testify.

Although clinical research into these advantages is still in progress, much is currently found out about the "energetic" active ingredients for managing frustration discomfort which are carried out via intravenous treatment.

MAGNESIUM

According to the American Migraine Culture (AHS), magnesium has to do with as close as it reaches the "wonder" frustration treatment.

As a matter of fact, doctors today often recommend magnesium in dental form to clients with persistent migraines. When suggested intravenously, it is generally offered as magnesium sulfate.

In 2012, the scientists with the AHS reviewed the research studies on drugs utilized for migraine prevention as well as offered magnesium a Level B ranking, mentioning that "it is possibly potent as well as should be considered for clients calling for migraine preventative treatment. Due to its security profile and the absence of serious negative effects, magnesium is frequently selected as a preventative technique either alone, or with various other preventive drugs."

Magnesium has actually revealed cause both upkeep doses and also for acute start treatment as well as alleviation. It has likewise delivered outcomes for different kinds of migraines, consisting of mood, pregnancy-related and also menstruation migraines.

Research studies indicate that magnesium may hold off cortical spreading anxiety, a stimulant for aura kinds of migraine headaches, while blocking neural discomfort signals and blood vessel constricting.

GLUTATHIONE

Glutathione has the power to detoxify the body as well as brain by removing heavy metals and various other toxins, while promoting the liver's capacity to filter them from the system. Because of this, drug store professional Suzy Cohen describes, glutathione offers a powerful source of relief from frustrations as well as migraines.

Glutathione itself is an anti-oxidant that is created naturally by the liver. Nevertheless, bad way of living choices as well as diet may severely influence as well as diminish all-natural glutathione books, triggering headaches, body health system suppression, and also persistent discomfort.

Glutathione supplies a powerful resource of remedy for headaches as well as migraines.

-- Suzy Cohen, "America's Pharmacist"

VITAMIN C.

Vitamin C is known to boost the body health system, support generally health, secure cells from damage, as well as assist secure the body from major as well as chronic condition.

For ongoing wellness problems such as chronic frustrations or migraines, research shows that receiving a high dose intravenously may jump-start and also aid sustain the recovery procedure in time.

WILL VITAMIN DRIP THERAPY ASSISTANCE ME?

The study to day shows that the response to this inquiry is likely to be "yes." With several medical companies and also migraine professionals currently making use of intravenous or mixture drip therapy to deal with frustrations and also migraine headaches, it's absolutely worth a try.

Expenses differ based upon the service provider, the recipe, the dosage as well as the frequency. In addition, it may be good to intend to get than just one vitamin drip to replenish depleted gets and also completely gain from the therapy.

The article “ VITAMIN DRIP THERAPY, A HELP FOR HYDRATION AND CHRONIC HEADACHES? “ was seen first on breslowmd.com

Find out how an IV therapy of vitamins may help improve your overall health. Drop by Dr. Amauri Wellness Centre located in Toronto, Ontario.

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paleorecipecookbook · 7 years

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The Dangers of Acetaminophen

Each week, around 23 percent of U.S. adults, or 52 million Americans, use a medication containing acetaminophen, according to the Consumer Healthcare Products Association (1). The ubiquitous use of acetaminophen, both by itself and as a component of over-the-counter and prescribed medications, is a major public health issue. Acetaminophen is generally considered safe when taken as recommended, but the margin between a safe dose and a potentially lethal one is incredibly small. Even when taken as recommended, acetaminophen use can have major side effects. In this article, I’ll discuss the many reasons we should avoid acetaminophen whenever possible and share several safer alternatives for pain relief.

Liver toxicity

Overdose with acetaminophen is the leading cause for calls to poison control centers in the United States, with more than 100,000 instances per year (2). It’s responsible for more than 56,000 emergency room visits and an estimated 458 deaths every year due to acute liver failure. In fact, over half of all acute liver failure cases in the United States are due to acetaminophen overdose (2). Taken over several days, as little as 25 percent above the maximum dose, or just two additional pills a day, has been reported to cause liver damage. This staggered overdosing may be more dangerous than a single large overdose (3).

Think twice before you reach for Tylenol.

Current guidelines recommend taking no more than 4,000 milligrams of acetaminophen daily (4). Yet according to a 2006 study published in the Journal of the American Medical Association, even this dose, taken for four or more days, frequently causes elevated serum alanine aminotransferase (ALT), a marker of liver injury. Moreover, the elevations in ALT often persisted for several days after the acetaminophen was discontinued (5). Concerns about liver toxicity were raised as early as 1977, when an FDA advisory panel said it was “obligatory” to add warning labels about liver damage. The FDA dragged its feet until 2011, when it finally issued a statement urging drug manufacturers to limit the strength of each capsule to 325 milligrams of acetaminophen and mandated warning labels about liver toxicity (4). Acetaminophen toxicity is increased when combined with narcotics like codeine or hydrocodone, when more than the prescribed dose was taken in a 24-hour period, when more than one acetaminophen-containing product is taken at the same time, or when alcohol is consumed while taking acetaminophen (6, 7). How does it cause liver damage? Acetaminophen depletes levels of glutathione, the body’s master antioxidant. Glutathione helps protect cells from damage by free radicals. Interestingly, prompt administration of N-acetylcysteine (NAC), the precursor to glutathione, can prevent mortality from acetaminophen toxicity (8).

Gut health and microbial drug metabolism

Chronic use of acetaminophen doses greater than 2,000 milligrams has been associated with a 3.7 times increased risk of bleeding in the upper gastrointestinal tract (9). Acetaminophen can also cause intestinal permeability. Overdose with acetaminophen causes massive necrosis of the liver tissue, which releases a protein that results in leakage of bacteria from the gut into the bloodstream (10). I’ve written before on the Kresser Institute blog about the role of the gut microbiota in drug metabolism. Interestingly, those with higher levels of certain gut bacterial metabolites may be more susceptible to acetaminophen toxicity (11).

Cardiovascular health, kidney disease, and cancer

Several recent studies have also shed light on acetaminophen’s relation to cardiometabolic health. One study, published just this month, found that those taking opiates (some of which contain acetaminophen) were 95 percent more likely to be obese and 63 percent more likely to have hypertension (12). Of course, we can’t separate out the effects of acetaminophen in these combination drugs. The kidneys are also affected by acetaminophen. Heavy use of acetaminophen is associated with an increased risk for kidney disease. This is especially true when combined with alcohol consumption. One study found that concomitant use of acetaminophen and alcohol resulted in a 2.23 times increased risk for kidney dysfunction (13). Researchers have also found associations with cancer. A 2013 meta-analysis of epidemiological studies found that acetaminophen was associated with a significantly increased risk of kidney cancer (14). A 2011 study of more than 64,000 older men and women found that acetaminophen use was also associated with several different types of blood cancers, including myeloid neoplasms, non-Hodgkin lymphomas, and plasma cell disorders like multiple myeloma (15).

Blunted emotions and empathy

Researchers at Ohio State University wanted to determine if acetaminophen affected emotional processing. They found that participants who took acetaminophen “evaluated unpleasant stimuli less negatively and pleasant stimuli less positively, compared with participants who took a placebo.” In other words, both negative and positive stimuli were less “emotionally arousing” to people who had taken acetaminophen (16). In another double-blind, placebo-controlled experiment led by a different research group, participants rated their perceived pain, personal distress, and empathic concern after reading scenarios about another person’s physical or social pain. Participants who had received acetaminophen beforehand showed less empathy towards others’ pain (17). Together, these studies raise concerns about the broader social side effects of acetaminophen. If a quarter of Americans use this every week, what impact is this having on us as a society?

Autism, ADHD, and brain health

Acetaminophen is currently marketed as safe during pregnancy. However, acetaminophen use may have neurodevelopmental consequences for the fetus. A 2016 study followed more than 2,000 mother–child pairs from the first trimester of pregnancy and performed several tests of behavior when the children were about five years old (18). Forty percent of the children were exposed to acetaminophen in utero. Exposure to acetaminophen was associated with lower attention function and a greater risk for ADHD-like hyperactivity and impulsivity symptoms. In boys, acetaminophen exposure was also related to a greater number of autism spectrum symptoms, and mothers who used acetaminophen more frequently had an even greater chance of having children with autistic-like behavior. The authors even ran the data again, excluding mothers that had chronic illness, urinary tract infections, or fevers during pregnancy, and found the same results, suggesting that it was not illness itself that contributed to the association. Some researchers hypothesize that activation of the cannabinoid system by acetaminophen may be affecting neural development (19). A study in rats found that acetaminophen causes toxicity to neurons even at concentrations too low to cause liver failure (20). It caused the neurons to undergo apoptosis, or programmed cell death.

Severe skin reactions and asthma

Acetaminophen has also been linked to rare but very serious skin reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis. These reactions can be fatal. Between 1969 and 2012, there were 107 such cases, of which 67 required hospitalization, and 12 people died. In 2013, the FDA issued a warning and mandated that skin reactions be listed on acetaminophen-containing drug labels as a potential adverse effect (21). Exactly how acetaminophen causes these potentially fatal skin reactions is unknown, but particularly alarming is that they can occur even if you’ve taken acetaminophen in the past without any problems. Researchers have also found an association between acetaminophen and asthma. A 2009 systematic review and meta-analysis found that in both adults and children, the risk of asthma increased with prior acetaminophen use. Moreover, prenatal exposure to acetaminophen also increased the risk of asthma in child, possibly by increasing oxidative stress during prepregnancy. (22) Of course, these are only associations, and they don’t prove that acetaminophen is the cause of these problems. Some of these children may have received acetaminophen due to viral respiratory infections that may have also contributed to the development of asthma. Still, the evidence is strong enough that several experts have recommended that acetaminophen use should be avoided in children with asthma or at risk for asthma (23, 24).

Altered reproductive function

Acetaminophen is also an endocrine disruptor. In a 2016 study, rats given acetaminophen had female offspring with fewer eggs, smaller ovaries, and smaller litters when they reached reproductive age. Male offspring had fewer numbers of sperm progenitor cells early in life, but these returned to normal by adulthood. Particularly concerning was the effect it had on the next generation. Granddaughters of the rats given acetaminophen were also found to have smaller ovaries and stunted reproductive function (25). How did this happen? The researchers speculate that it has to do with acetaminophen’s effect on prostaglandins, hormones that are involved in pain and inflammation but are also important in regulating female menstrual cycles and reproduction. In humans, acetaminophen use during pregnancy, especially for durations of more than four weeks, is associated with an increased risk of having male children with an undescended testicle at birth (26). Prolonged exposure to acetaminophen also decreases the amount of testosterone produced by human fetal testes (27), which could have major effects on male development.

Alternatives to acetaminophen

Hopefully, I’ve convinced you to think twice about taking acetaminophen. Ultimately, pain is a sign of a deeper problem, and throwing pills at it is only suppressing symptoms. Eating an anti-inflammatory diet, getting adequate sleep, exercising, getting exposure to sunlight, and managing stress are all part of an effective pain-management strategy. For acute relief, there are some alternative painkillers that are far less toxic and, in many cases, just as effective as acetaminophen. Here are a few that I always keep in my “medicine” cabinet:

Curcumin: a potent anti-inflammatory, curcumin is one of the natural compounds found in turmeric. I recommend 1,500 mg up to three times a day of the Meriva-SR form, which is much more bioavailable than other forms of curcumin. (Note: curcumin is contraindicated if you are taking blood thinners.)

Magnesium: three of the most common reasons for taking acetaminophen over the counter are headaches, muscle pain, and menstrual cramps. For many people, magnesium can provide significant relief from these symptoms, often equivalent to or better than Tylenol. I recommend 400 to 600 mg of the magnesium glycinate form.

Boswellia: another anti-inflammatory, the resin of the Boswellia tree has been used medicinally for centuries. It works via a different mechanism than curcumin, so they are complementary when taken together. I recommend 100 mg up to three times a day in the AKBA form.

Clove oil: works like a charm for toothaches. Mix a few drops of therapeutic-grade clove oil with a spoonful of coconut oil and swish it around the mouth.

CBD oil: also known as cannabidiol, this is the non-psychoactive oil of the cannabis plant that has pain-relieving and anti-inflammatory properties. It does not produce the “high” that THC does, and as of now, it is currently sold legally over the counter. I recommend one to two droppersful once or twice a day of the Ojai Energetics Super CBD product.

Acupuncture: can be quite effective at modulating local and systemic pain and reducing inflammation.

Mind-body interventions: emotional-freedom techniques, yoga, and meditation can all provide short-term pain relief.

Now I’d like to hear from you. Did you know the dangers of acetaminophen? What do you use for pain relief? Share your thoughts in the comments below.

Source: http://chriskresser.com January 23, 2018 at 06:11PM

#paleo #recipe #food #delicious #healthy #yum #diet

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itsnirmal888 · 4 years

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New Post has been published on https://pickstofit.com/all-about-nac-supplement-benefits-side-effects-dosages/

All About NAC: Supplement Benefits, Side Effects, Dosages

Our understanding of how antioxidant supplementation works has changed in the last decade. Rather than act directly as antioxidants, most of these compounds stimulate the body’s own production of endogenous antioxidants. That’s right—most of the popular and beneficial “antioxidant” supplements work by provoking a mild hormetic stress response that activates our own antioxidant defenses.

But homegrown antioxidants aren’t made out of thin air. They are material substances that require physical building-blocks. Probably the most important antioxidant is glutathione, and its most important building block is NAC.

What is NAC?

N-acetyl-cysteine, or NAC, is the stable, supplement form of the amino acid cysteine. Cysteine provides one of the most crucial backbones undergirding the body’s premier antioxidant: Glutathione.

In the conventional medical world, NAC is mainly used to rescue people from acetaminophen toxicity. If you overdose on Tylenol and get to a doctor within 8 hours, they’ll give you a big dose of NAC to save your liver and your life. But how does it work? How does NAC beat Tylenol toxicity?

By increasing glutathione stores in the liver. Glutathione binds to the toxic Tylenol metabolite and makes it harmless, but it doesn’t last forever. A big dose of a major toxin like Tylenol is enough to deplete glutathione stores and increase acute glutathione requirements. NAC provides the raw material for glutathione production, allowing it to commence and get to protecting.

Might this have other effects? Does glutathione do anything else?

It reduces reactive oxygen species down to less damaging metabolites.

It is the master detoxifier, a major line of defense against invading mutagenic, carcinogenic, and inflammatory agents.

It defends against glycation.

It controls hundreds of proteins in the body.

Instantly access our FREE download: Guide to a Healthy Gut

It protects against lung damage and maintains respiratory function, especially in the context of infectious respiratory diseases.

It regulates glutamate levels in the brain, reducing over-excitation.

In other words, it does a lot. We should probably try to keep our levels up. If we don’t?

Well…

Low levels of glutathione have been linked to such disparate conditions as diabetes, tuberculosis, cancer, HIV, and aging. Heart failure patients tend to have low glutathione. Low glutathione levels are generally associated with elevated markers of inflammation, like CRP.

Okay, so glutathione is important, low levels are linked to many different diseases and health conditions, it’s a good idea to have adequate levels for general health, and NAC is one of the better ways to replenish glutathione. At normal doses of Tylenol, taking NAC along with it prevents glutathione depletion without negatively affecting the therapeutic effect of the drug.

NAC helps the liver metabolize alcohol, too, by speeding up the clearance of its most toxic metabolite—acetaldehyde. In rats, NAC even mitigates the hypertensive effect of drinking alcohol, suggesting general detoxification effects.

Detoxification with NAC

All those “experts” who say detox is a myth and your body is perfectly able to detoxify everything it needs to without fancy supplements and therapies are half-right. The body is able to detoxify a wide range of toxins, provided we give it the substrates it requires. NAC is one such substrate that seems to help us deal with incoming toxins.

In workers with chronic lead exposure, NAC increases antioxidant capacity in red blood cells, reduces oxidative stress, and lowers blood levels of lead.

In adults with acute pesticide poisoning, NAC (600 mg 3 times per day) reduces inflammatory markers and the need for atropine (a pharmaceutical that treats pesticide poisoning).

After exposure to diesel fumes, taking NAC reduces blood vessel damage and, in asthmatic patients, lowers the airway responsiveness.

NAC even reduces the toxic effects in people who eat poison mushrooms or get dosed with mustard gas.

If large doses of NAC can help people deal with serious toxin loads, moderate doses of NAC can probably help people deal with normal loads.

NAC and Lung Health

In bronchitis and Chronic Pulmonary Obstructive Disease (COPD), the lungs lose glutathione and accumulate too much thick mucus, reducing their function and making it harder to breathe. When you take NAC in this situation, it replenishes lung glutathione and thins out the mucus.

The result is that bronchitis patients who take NAC over the course of 3-6 months experience lower rates of “exacerbations” (worsening episodes) and see their symptoms improve. Same goes for COPD patients on a year-long course of NAC; they enjoy improved lung capacity.

Flu Resistance

One study in older adults had some remarkable results. Subjects were randomized to one of two groups. The first group got placebo. The second group got 600 mg of NAC, twice a day, for 6 months. Over the course of the study, they tracked “influenza-like” symptoms, finding that the NAC group had far fewer than the placebo group. Then they tested the subjects for influenza antibodies and found that both groups had equal seroconversion rates. Both groups were equally likely to have gotten the flu over the 6 months, but just 25% of the infected NAC group ever showed symptoms versus 79% of the infected placebo group who showed symptoms.

NAC Reduces Inflammation and Oxidative Stress

The modern world is a stressful place. We have long commutes to jobs we often dislike. We’re stuck indoors when we’d rather be outside in the fresh air and sunlight. We have to closely read labels—or avoid them altogether—to make sure we’re eating healthy fare. The air is polluted, we’re disconnected from nature, we sit too much and move too little. I’m not saying this to be a downer or alarmist—the world remains a beautiful place full of joy and wonder—but a realist. Life is good but our bodies are under constant, chronic low-level assault from evolutionarily novel physiological and psychological stressors.

Increased oxidative stress is the baseline for too many people, and NAC has been shown to be one of the best “all-purpose” supplements for reducing it.

Mental and Psychological Health

NAC checks off a few important boxes for mental health. It crosses the blood brain barrier, reduces oxidative stress, and regulates glutamate levels in the brain. Now, glutamate isn’t “bad,” but too much glutamate in the wrong places can lead to over-excitation. That’s often what we see in mental and psychological disorders—over-excitation, excessive activity.

NAC smoothes that out. It sticks glutamate where it belongs in the right concentrations. It provides the right amount of inhibition to counter the excitation.

This is probably why NAC supplementation has shown preliminary promise in treating a number of disorders, including autism, Alzheimer’s disease, cocaine and cannabis addiction, bipolar disorder, depression, trichotillomania, nail biting, skin picking, obsessive-compulsive disorder, schizophrenia, anxiety, attention deficit hyperactivity disorder and even mild traumatic brain injury.

NAC and Fertility

Both male and female infertility often come down to elevated oxidative stress. Can NAC reduce stress? Yes. Can NAC improve fertility? Yes.

In men visiting a fertility clinic, an NAC supplement (600 mg/day for 3 months) increased serum antioxidant capacity, reduced oxidative stress, and improved sperm quality, motility, and consistency.

A combo of selenium and NAC was also able to improve semen quality in men with fertility issues.

As for women’s fertility, NAC seems to be most effective in women with PCOS already taking clomiphene citrate (a PCOS drug meant to stimulate fertility). A pair of studies found that NAC increased both ovulation and pregnancy rate in women with PCOS who had proven resistant to clomiphene citrate alone.

Should Everyone Take NAC?

Not necessarily. Most of its benefits occur in people with depleted glutathione levels and/or elevated inflammatory status.

One paper found that NAC was only helpful in patients with depleted glutathione levels. Those with low glutathione saw platelet function improvements, while those patients with normal glutathione levels saw no improvements in their platelet function.

Another paper found similar results with depression. Only those patients with elevated CRP levels at baseline experienced a reduction in depressive symptoms after taking NAC.

And most of the studied health conditions are quite serious and, relatively speaking, rare. What draws me in is the fact that glutathione is upstream of so many different physiological processes. It’s not some specific compound with very limited application or relevance. It’s a specific compound with broad applications.

You may not have the glutamate over-excitation issues of someone with full-blown schizophrenia or social anxiety disorder, but a little NAC might help you focus or improve your internal self-talk.

You may not have COPD, but making sure your lung glutathione stores are replete isn’t a bad idea.

You’re probably not completely infertile, but reducing oxidative stress and improving sperm or endometrial quality never hurt anyone’s chances.

All that said, NAC is one of the safer supplements available. It probably won’t hurt to try a small dose whether you have elevated inflammation or depleted glutathione or not—and many people do have suboptimal glutathione status without knowing it.

What’s a Good NAC Dosage?

Many of the therapeutic effects used in the studies I referenced today were in the 500-600 mg range. Sometimes higher, but not necessarily.

I included 500 mg of it in my broad-spectrum micronutrient supplement, Primal Master Formula, because that is a well-tolerated, well-attested dose that’s safe to use and quite effective at glutathione maintenance.

I am a very light/moderate drinker these days, but whenever I do have more than usual, I’ll take 500 mg of NAC and 500 mg of vitamin C about an hour before drinking. This dose seems to improve the positive effects and reduce any negative side effects, probably by increasing glutathione, enhancing ethanol metabolism, and clearing acetaldehyde more quickly.

That’s it for NAC, folks. If you have any questions or comments, drop them down below.

About the Author

Mark Sisson is the founder of Mark’s Daily Apple, godfather to the Primal food and lifestyle movement, and the New York Times bestselling author of The Keto Reset Diet. His latest book is Keto for Life, where he discusses how he combines the keto diet with a Primal lifestyle for optimal health and longevity. Mark is the author of numerous other books as well, including The Primal Blueprint, which was credited with turbocharging the growth of the primal/paleo movement back in 2009. After spending three decades researching and educating folks on why food is the key component to achieving and maintaining optimal wellness, Mark launched Primal Kitchen, a real-food company that creates Primal/paleo, keto, and Whole30-friendly kitchen staples.

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kristinsimmons · 4 years

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COVID-19: Hidden Coinfections and Chain Reactions Parasitic Infectious Relationships within Us

By SIMON YU, MD, LT COL, USA (Ret)

Dr. Tom Frieden, former director of the Centers for Disease Control and Prevention (CDC), opened up a new front in the Coronavirus War by saying we don’t just need to treat the acute disease, we need to treat the underlying conditions that make people more susceptible to serious disease progression. He focused on heart disease, and managing mitigating risk factors such as CVD, diabetes, hypertension and smoking in order to increase people’s odds for recovery. The initial focus has been pneumonia and acute respiratory distress syndrome (ARDS), with risk factors including asthma, chronic obstructive pulmonary disease, and emphysema.

Dr. Frieden calls for better management of people’s underlying health problems to help mitigate the impact of COVID-19. I would take this one step further and say we need to go beyond managing chronic diseases, and find and treat the pathogens that underlie and fuel their pathologies. Why?

In 2001, my work as an Army Reserve medical officer took me to Bolivia to treat 10,000 Andes Indians with parasite medications. Not only did this resolve their parasite problems, but many reported it helped them overcome a range of additional chronic health problems. When I returned to St. Louis, I began to dig deeper with my chronic disease and “mystery disease” patients and treat some of them for parasite problems, and saw many improve. I expanded this “search and destroy” mission with my patients to fungal and dental infections, as I learned many such infections – often overlooked in medicine today – are overlapping, synergistic, and can present as chronic illness.

The more I learned about the importance of a healthy biological terrain and the importance of a healthy immune system, the more I began to apply military thinking and strategy to medicine, and paradoxically, help the body find peace within itself. Sun Tzu wrote, “The supreme art of war is to subdue the enemy without fighting,” in his classic, The Art of War. I learned the best way to do that is strengthen the immune system, by focusing on such basics as nutrition, exercise, sleep, and emotional balance. When it comes to chronic illnesses, my belief is that we should not fight symptoms, a diagnosis or a syndrome, but improve the biological terrain, and counter the underlying asymmetric threats.

The importance of a multipronged effort to strengthen the immune system and treat the multiple pathogens that lead to an inflammatory cascade is underscored by new CDC data on COVID-19 in the U.S. Of 7,162 cases from mid-February to late March with complete information, the CDC found that 78 percent of people requiring admission to an intensive care unit (ICU) had at least one underlying health condition. Of people hospitalized but not requiring ICU admission, 71 percent had at least one such condition, compared with just 27 percent of people who didn’t need to be hospitalized. The biggest risk factors contributing to hospitalization and ICU admission were diabetes, lung disease and CVD.

In addition to preexisting heart, lung and metabolic conditions, another major risk factor is an overactive immune system – a “cytokine storm.” According to Dr. Randy Cron of the University of Alabama at Birmingham, in as much as 15 percent of people battling any serious infection, “the immune system keeps raging long after the virus is no longer a threat. It continues to release cytokines that keep the body on an exhausting full alert. In their misguided bid to keep the body safe, these cytokines attack multiple organs including the lungs and liver, and may eventually lead to death.” This may be the turning point from a mild to miserable respiratory illness into life-threatening organ failure.

TABLE 1. Reported outcomes among COVID-19 patients of all ages, by hospitalization status, underlying health condition, and risk factor for severe outcome from respiratory infection — U.S. February 12–March 28, 2020

Underlying health condition/ Risk factor for severe outcomes Not hospitalized Hospitalized, non-ICU ICU admission Hospitalization status unknown (top three conditions listed below) (number, percent with condition) Total w/ complete information (7,162) 5,143 1,037 457 525 One or more conditions (2,692, 38%) 1,388 (27%) 732 (71%) 358 (78%) 214 (41%) Diabetes mellitus (784, 11%) 331 (6%) 251 (24%) 148 (32%) 54 (10%) Chronic lung disease (656, 9%) 363 (7%) 152 (15%) 94 (21%) 47 (9%) Cardiovascular disease (647, 9%) 239 (5%) 242 (23%) 132 (29%) 34 (6%)

Source: http://dx.doi.org/10.15585/mmwr.mm6913e2

What have I learned in my years of medical practice as a regional HMO director, 25 years in the US Army Reserve Medical Corps, and as director of Prevention and Healing, Inc. in St. Louis? The asymmetric threats most often overlooked are parasites, fungal infections, and dental problems. Viruses are technically parasites, a gray area between living and nonliving: they cannot replicate on their own but do so in living cells. They have been evolving with us and some of them are encoded as a part of our genetic code from the point of evolution of biological life. They are unique and complex, composed of a protein coat surrounding RNA or DNA core genetic materials. They can stay dormant for many years or be active seasonally, and are capable of growth and multiplication only in living cells as unwanted guests, just like parasites. Parasites have their own parasites, fungi, mycoplasma, bacteria and many types of viruses. The slide below is part of my lecture explaining the evolution of life and parasites, coinfections and parasitic relationships from a universal, simplified perspective.

FIGURE 1. The Kingdoms of Life: Creation, Evolution and Co-Creation

The coronavirus is deceptive and creates a hidden chain reaction. COVID-19 will attack aggressively already vulnerable aging populations and immune-compromised, chronically ill patients, young or old. Many patients are nutritionally depleted and cannot support their immune system, so rapidly succumb to the viral infection. By the time one develops pneumonia, COVID-19 may activate dormant, inactivated bacteria, fungi, mycobacteria and parasites that were previously under the surveillance of the immune system. COVID-19 pneumonia patients may be fighting more than viral infection but also bacterial, mycobacterium-TB like infection, fungi and reactivated parasites, including dental infections. Prevotella have been found in lungs of COVID patients in three Asian studies; it is often found in dental infections.

Coinfections might explain why some patients respond to hydroxychloroquine, an antimalarial parasite medication, and azithromycin, an antibiotic for pneumonia, one of numerous treatment strategies now being tested. Hydroxychloroquine facilitates uptake of zinc into cells, which interrupts viral replication. Another repurposed medication being tested is losartan, an angiotensin-converting enzyme (ACE) inhibitor blood pressure medication. ACE-2 is the host cell receptor responsible for mediating infection by SARS-CoV-2, the novel coronavirus responsible for coronavirus disease 2019 (COVID-19). Treatment with anti-ACE-2 antibodies disrupts the interaction between virus and receptor.

Physicians in Shanghai report help from using high and frequent dose IV Vitamin C. A clinical trial using Vitamin C for coronavirus is underway in China, and it is also in use in some New York City hospitals. While pharma companies are eager to fund trials of costly patented drugs, we also need to test combinations of existing drugs and nutrients to find more accessible, affordable solutions.

For prevention and prophylactic measures, I recommend extra vitamin C up to 10,000mg/day, 10,000 IU of vitamin D3, vitamin K2, selenium, zinc, boron, and herbal and homeopathic remedies for viral respiratory illnesses, such as elderberry extract. Glutathione can be used for general immune support. I am not saying this will prevent or stop COVID-19, but help you be in a stronger position to fight it.

In the face of the coronavirus pandemic ravaging the US, the FDA has rapidly issued a series of Emergency Use Authorization (EUA) Updates for Coronavirus Disease (COVID-19) which cover In Vitro Diagnostic Products, Personal Protective Equipment, Other Medical Devices, and Therapeutics. In addition, FDA approved two new treatments being used overseas in late March: convalescent plasma therapy, and hydroxychloroquine, an antiparasitic used for malaria, lupus, and rheumatoid arthritis. Both of these have a long history of successful use for other diseases, side effects are understood and should be monitored, and clinical trials are being initiated.

The Food and Drug Administration (FDA) has created a special emergency program for possible therapies, the Coronavirus Treatment Acceleration Program (CTAP). As of this writing, there are 10 therapeutic agents in active trials, and another 15 in planning stages. FDA invites new requests for product development for proposed COVID-19 uses and drug development submissions at [email protected].

There is a good deal of controversy in medical circles about whether the FDA is moving too fast, or too slowly, in clinical trials and drug approval. Given the gravity of the challenges we face, it is time to put aside intellectual biases, and be open to new strategies. It is time for “all hands on deck.”

Just as public health strategies of isolation, quarantine and containment play a vital role in pandemics – in addition to emergency medicine and targeted therapeutics – there is an important role for preventive and integrative medicine. We need to treat the whole body and strengthen the biological terrain to be ready to confront both novel viruses and longstanding pathogens that contest for living among, within, and off of us. We need extra help in the face of the asymmetric threats we confront in the challenging months ahead in our families, our nation, and our stressed and overstretched healthcare system.

Simon Yu, MD, Lt Col (Ret), practices internal and integrative medicine at Prevention and Healing, Inc. in St. Louis; his latest book is, AcciDental Blow Up in Medicine: Battle Plan for Your Life.

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lauramalchowblog · 4 years

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COVID-19: Hidden Coinfections and Chain Reactions Parasitic Infectious Relationships within Us

By SIMON YU, MD, LT COL, USA (Ret)

Source: http://dx.doi.org/10.15585/mmwr.mm6913e2

FIGURE 1. The Kingdoms of Life: Creation, Evolution and Co-Creation

Simon Yu, MD, Lt Col (Ret), practices internal and integrative medicine at Prevention and Healing, Inc. in St. Louis; his latest book is, AcciDental Blow Up in Medicine: Battle Plan for Your Life.

The post COVID-19: Hidden Coinfections and Chain Reactions Parasitic Infectious Relationships within Us appeared first on The Health Care Blog.

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dreddymd · 5 years

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Inflammation and Pain Management with Magnesium

Inflammation plays a pivotal role in all stages of atherosclerosis, which is the progressive narrowing and hardening of the arteries over time.

Inflammation is the activation of the immune system in response to infection, irritation, or injury. Characterized by an influx of white blood cells, redness, heat, swelling, pain, and dysfunction of the organs involved, inflammation has different names when it appears in different parts of the body. Most allergy and asthma sufferers are familiar with rhinitis (inflammation of the nose), sinusitis (inflammation of the sinuses), and asthma (inflammation of the airways), but inflammation is also behind arthritis (inflammation of the joints), dermatitis (inflammation of the skin), and so on.

The inflammatory response can be acute or chronic. Acute inflammation typically lasts only a few days. This response usually promotes healing but, if uncontrolled, may become harmful.

The primary objective of acute inflammation is to localize and eradicate the irritant and repair the surrounding tissue but this completely changes in chronic low-grade inflammatory states. Chronic low-grade inflammation is one of the characteristics of the metabolic syndrome and interferes with insulin physiology. Ignorance has prevailed over the interrelationship between muscular lipid accumulation, chronic inflammation and insulin resistance because the central mediating factor is magnesium. It is magnesium that modulates cellular events involved in inflammation.

There are many factors that trigger inflammation. They are found in both our internal and external environments and include excessive levels of the hormone insulin (insulin resistance), emotional stress, environmental toxins (heavy metals), free-radical damage, viral, bacterial, fungal other pathogenic infections, obesity, overconsumption of hydrogenated oils, periodontal disease, radiation exposure, smoking, spirochetes such as the Borrelia that causes Lyme disease, and certain pharmacological drugs. Problems with insulin metabolism are a major contributor to cardiovascular disease. It results in the inability to properly store magnesium, causing blood vessels to constrict, elevated blood pressure, and coronary arterial spasm, all of which can result in a heart attack.

Excess insulin causes retention of sodium, fluid retention, elevated blood pressure and congestive heart failure.[1]– Dr. Ron Rosedale

Inflammatory reactions in the body are a valuable predictor of impending heart attack. Dr. Robert Genko, editor of the American Academy of Periodontal Journal, claims that persons with gingival disease (which is an inflammatory disorder) are 27 times more likely to suffer a heart attack than are persons with healthy gums. An American Heart Association paper disclosed that 85% of heart attack victims had gum disease compared to 29% of healthy similar patients.

When magnesium levels fall researchers note a profound increase of inflammatory cytokines present, along with increased levels of histamine.[2]

Magnesium deficiency causes and underpins chronic inflammatory build ups.This concept is intriguing because it suggests a fundamentally simpler way of warding off disease. Instead of different treatments for heart disease, Alzheimer’s and colon cancer, we apply a single, inflammation-reducing remedy that would prevent or treat these and other deadly diseases. The key words here are ‘prevent’ or ‘treat’ but please notice the word is not cure. Though magnesium is a cure for many of our ailments full treatment protocols are recommended with magnesium chloride as the top protocol item. It is a protocol of basic items like magnesium, iodine, Alpha Lipoic Acid, sodium bicarbonate, sodium thiosulfate, whole food vitamin C, natural vitamin D from the sun, spirulina and some other important items like purified water that will make a difference in a host of chronic diseases.

Once we understand the critical importance ofinflammation and glutathione depletion in brain diseases, we can take steps to prevent or even reverse the damage.– Dr. David Perlmutter

Inflammation and systemic stress are central attributes of many pathological conditions. In magnesium we have found a potent medicinal that is effective across a wide range of pathologies. Pharmaceutical companies need look no further then the sea shore, which contains millions of tons of magnesium chloride the perfect anti-inflammatory agent.

Is your heart on fire?[3]– New York Times

It could very well be but we most likely will not know it until we suddenly have cardiac arrest. Researchers recognize a silent kind of inflammation. This type of internal inflammation has an insidious nature and is the culprit behind diabetes and heart disease. The chronic and continuous low-level stress that silent inflammation places on the body’s defense systems often results in an immune-system breakdown. Magnesium deficiency is a parallel silent insult happening at the core of our physiology. Magnesium deficiencies feed the fires of inflammation and pain.

Epidemiologic studies have shown an inverse relationship between magnesium in the drinking water and cardiovascular mortality[4],[5]. This association between magnesium in drinking water and ischemic heart disease was reconfirmed in a major review of the literature done by epidemiologists at Johns Hopkins University.[6] Since most heart disease is marked by various levels of inflammation these studies were all highlighting the hidden relationship between inflammation and magnesium deficiency.

Another reason that chronic inflammations can take us into the hell fires of pain is that magnesium gets depleted in conditions of inflammation.

Beyond all the common symptoms of inflammation we find the body tissues themselves may lose their ability to recognize cells that are “self ” from those that are not, and the body may mistakenly identify its own cells as foreign invaders. This internal programming error then continues to trigger and retrigger immune responses, setting the stage for autoimmune diseases, such as lupus, multiple sclerosis, and scleroderma. The result is cellular chaos, and what is even more disturbing is that this process may be happening year after year without our even being aware of it.

This chronic inflammatory response breaks down healthy tissue in a misdirected attempt at repair and healing.

Doctors who specialize in rheumatoid arthritis, multiple sclerosis, lupus and other autoimmune disorders are very familiar with what happens when the body goes to war with itself. These diseases demonstrate a direct inflammatory attack against healthy cells in such places as the joints, nerves and connective tissue.

Magnesium is central to immunocompetence and plays a crucial role in natural and adaptive immunity.[7]

Alzheimer’s patients who were already taking anti-inflammatory drugs for arthritis or heart disease tend to develop the disorder later than those who weren’t.

Atherosclerosis is caused by chronic inflammation, which often begins very early in life. The big dispute among experts is what causes the inflammation in the first place. One theory holds that bacteria and viruses may cause this inflammation but clearly we know that lead, mercury, monosodium glutamate (MSG) and fluoride and other toxic chemicals can also cause inflammatory reactions in blood vessels.

Recent advances in the field of cardiovascular medicine have emphasized the involvement of inflammation in the formation of atherosclerotic plaque.

This chapter represents basic research into the nature of inflammation. It looks beyond the pharmaceutical companies; beyond aspirin and other multipurpose experimental drugs that block inflammation, but not without collateral damages. Magnesium is at the heart of the inflammatory process, it is the prime first cause when it is not present in sufficient quantities. Increases in extracellular magnesium concentration cause a decrease in the inflammatory response while reduction in the extracellular magnesium results in inflammation. Inflammation causes endothelial dysfunction and activated endothelium facilitates adhesion and migration of cancer cells.[8]

Chronically inflamed tissues continue to generate signals that attract leukocytes from the bloodstream. When leukocytes migrate from the bloodstream into the tissue they amplify the inflammatory response.

Magnesium literally puts the chill on inflammation. Heart disease begins with inflammatory chemicals that rage like a fever through your blood vessels. Cool the heat by getting the recommended daily minimum of magnesium suggests Medical University of South Carolina researchers. They measured blood inflammation levels–using the C-reactive protein (CRP) test–in 3,800 men and women and found that those who got less than 50% of the RDA (310 to 420 mg) for magnesium were almost three times as likely to have dangerously high CRP levels as those who consumed enough. Being over age 40 and overweight and consuming less than 50% of the RDA more than doubled the risk of blood vessel-damaging inflammation.[9]

Chronic inflammation destabilizes cholesterol deposits in the coronary arteries, leading to heart attacks and strokes.

A study performed by the VA Administration, published in JADA, 1998 on 10,000 US veterans, showed that most coronary heart disease started as an endothelial infection and in most cases was caused by pathogens. Recognizing the role of inflammation in arteriosclerosis represents a huge paradigm shift for cardiologists. The American College of Cardiology, the American College of Physician’s and the American Heart Association largely ignores the involvement of inflammation in heart attacks and strokes and certainly they ignore unresolved psycho-emotional trauma, as well as the toxic build up of mercury which can lead to massive heart failure and sudden death even in the healthiest athlete.

Inflammation not only further damages the artery walls, leaving them stiffer and more prone to plaque buildup, but it also makes any plaque that’s already there more fragile and more likely to burst.

A 2006 issue of the Journal of the American College of Nutrition an article showing that as consumption of magnesium fell, the levels of C-reactive protein went up. C-reactive protein, or CRP, is produced in the liver and has emerged as a strong predictor of clinical events of cardiovascular diseases, such as heart attacks and stroke, even in cases where cholesterol levels may be normal. For this reason, CRP assays may become a routine part of blood tests for determining CVD risk. CRP levels in the blood are normally undetectable or very low; high levels are strongly associated with inflammation.

Inflammation is the missing link to explain the role of magnesium in many pathological conditions.

Persistent asthma is an inflammatory disease that requires regular anti-inflammatory therapy with magnesium chloride.

This new view of inflammation is changing the way some doctors’ practice but most cardiologists are still not ready to recommend that the general population be screened for inflammation levels. Cardiologists don’t know it but when in rare instances they test for serum magnesium levels they are not measuring anything but strictly controlled magnesium levels in the blood. There continues to be a blind spot the size of the Gulf of Mexico in cardiologists’ perceptions. They just are not able to get to the bottom of the inflammation story – which is magnesium deficiency.

Magnesium decreases swelling, and, “is effective in the treatment of inflammatory skin diseases.[10]

Scientists at the Joslin Diabetes Center in Boston, have bred a strain of mice whose fat cells are supercharged inflammation factories. “We can reproduce the whole syndrome (diabetes) just by inciting inflammation,” Dr. Steve Shoelson says. This suggests that a well-timed intervention in the inflammatory process might reverse some if not all the effects of diabetes. Some of the drugs that are already used to treat the disorder, like metformin, may work because they also dampen the inflammation response. In addition, preliminary research suggests that high CRP levels may indicate a greater risk of diabetes.

Whatever makes us become less efficient at using insulin is going to aid in the development of diabetes. Treatments for diabetes work by replacing insulin, boosting its production or helping the body make more efficient use of the hormone.

Modern medicine is just starting to admit that chronic inflammation is the main contributing factor to heart disease and it is just about to discover magnesium chloride as a supremely safe and effective anti inflammatory. Magnesium chloride safely reduces inflammation and systemic stress because magnesium deficiencies are in great part the cause of both conditions.

People with magnesium deficiency can’t properly metabolize important fatty acids such as EPA and DHA, which are vital to heart health.

There are literally hundreds of physiological reasons to proclaim magnesium the ultimate heart medicine; its involvement in hundreds of enzyme reactions is just a start. Its use as an anti inflammatory makes magnesium absolutely indispensable to not only heart patients but also to diabetics, neurological and cancer patients as well. The treatment of chronic inflammation has been problematic for medical science because most of their treatments create more inflammation. Magnesium chloride does not do this.

Virtually all the components of the Metabolic Syndrome of diabetes, high blood pressure, obesity and lipid disorders are associated with low magnesium.– Dr. Michael R. Eades

Dr. Eades insists that theentire Metabolic Syndrome is nothing but a manifestation of a magnesium deficiency. He says, “Why are so many people deficient in magnesium? Because there are no single foods that contain huge amounts of magnesium, and because there is no single food containing large amounts, there is no magnesium lobby. Look at calcium. Thanks to the dairy industry, we are constantly told that we need to get enough calcium, and we’re told right where we can get it. Milk and cheese. Same with vitamin C. The orange juice people never let us forget. Not so with magnesium, so no one really thinks of it. Another reason that many people are magnesium deficient is that they drink bottled water or softened water. In the old days everyone drank well water or water from streams, both of which contain large amounts of magnesium. Magnesium is removed when water is softened and it isn’t in large amounts in most of the bottled waters that are available.”

Inflammation contributes to the pro-atherogenic changes in lipoprotein metabolism, endothelial dysfunction, thrombosis, hypertension and explains the aggravating effect of magnesium deficiency on the development of metabolic syndrome.– Dr. Andrzej Mazura

Dr. A. Mazur, et. al.[11] have shown in experimentally induced magnesium deficiency in rats that after only a few days a clinical inflammatory syndrome develops and is characterized by leukocyte (white blood cell) and macrophage activation, release of inflammatory cytokines and excessive production of free radicals. “Magnesium deficiency induces a systemic stress response by activation of neuro endocrinological pathways,” writes Dr. Mazur. “Magnesium deficiency contributes to an exaggerated response to immune stress and oxidative stress is the consequence of the inflammatory response,” he continued.

Long-term air pollution exposure is associated with neuro-inflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults.[12]

Magnesium-deficient rats develop a generalized inflammation.[13]– Dr. Sophie Begona

It turns out that statins don’t just lower cholesterol levels; they also reduce inflammation.The lipid hypothesis of heart disease is rapidly being supplanted by the inflammatory hypothesis. The researchers who have spent their careers doing cholesterol research are falling further and further into disfavor as most scientists are showing graphs demonstrating that elevated cholesterol in combination with an elevated C-reactive protein is a better gauge of heart disease risk. It seems that without the inflammation elevated cholesterol is not a threat after all.

Dr. Andrzej Mazura and team at Milan University confirmed that magnesium modulates cellular events involved in inflammation. Experimental magnesium deficiency in the rat induces, after only a few days, a clinical inflammatory syndrome characterized by leukocyte and macrophage activation, release of inflammatory cytokines and acute phase proteins; and excessive production of free radicals. Increase in extracellular magnesium concentration, decreases inflammatory response while reduction in the extracellular magnesium results in cell activation.[14], [15]

Today the most prescribed of all are drugs is used to lower “bad” LDL cholesterol. For those who are still interested in the cholesterol connection niacin (vitamin B-3) in high doses is as effective, much cheaper, and most importantly, far safer then any drug.[16] Niacin also dramatically lowers triglycerides. The New York Times said, “An effective HDL booster already exists. It is niacin, the ordinary B vitamin. Niacin can increase HDL as much as 35 percent when taken in high doses, usually about 2,000 milligrams per day . . . and it has been shown to reduce serum levels of artery-clogging triglycerides as much as 50 percent.”[17]

Inflammation is a response from your immune system in response to an irritant. For example, if you sprain your ankle, your immune system creates a protein called a Circulating Immune Complex (CIC for short). The CIC travels down to the injured ankle and causes pain and swelling. The pain you feel is to inform you of the injury or damage. And the swelling is protective as it prevents you from moving it and causing more irritation. This is also your body’s way of running to the problem with fresh blood, antibodies and vital cells in order to begin healing and repairing the damage.

Then what normally happens is our bodies produce proteolytic enzymes which counteract the inflammation, and things return to normal. That’s why a sprained ankle as a young child heals within a few weeks at most, but can take six weeks or more for an adult of say 45. The problem is, after around age 25, our production of these enzymes drops off almost completely so there is nothing to tell the body to stop the inflammation. These enzymes are also responsible for cleaning the blood, fighting off viral and bacterial infections and breaking down excess fibrin (scar tissue). Most if not all of these enzymes are mediated by magnesium meaning as magnesium levels drop off so do the activities of these crucial biological magnesium sensitive enzymes.

Enzymes break down scar tissue and fibrosis. Fibrosis is scar tissue that builds up in our bodies and over time creates some much restriction and strain on our organs that they can no longer function properly. Enzymes also clean the blood of excess fibrin that causes the blood to thicken, which sets us up for clots, which can cause heart attack or stroke. Enzymes also help take some of the strain off of the liver by keeping the blood clean and not allowing it to thicken beyond normal. Enzymes are very important in inflammation and enzymes bring us back to their fundamental supporter, which is magnesium.

When I received the following account from my research assistant Claudia French, who is an RN in an acute care psychiatric hospital, I realized that we should address the issue of magnesium, inflammation and pain more directly.

Yesterday I witnessed one of the most amazing benefits of transdermal magnesium I have seen. I work with another RN who is afflicted with arthritis, especially in her hands, and frequent muscle cramping/spasms in her legs. She has been using magnesium but became lax. Before leaving for work yesterday I received a phone call from her begging me to please bring with me some magnesium oil, as her hands were so cramped up and painful that she could barely stand to continue working.

When I got there, her hands and fingers were very contorted in spasm. Her fingers were curled up and stiff and her legs were cramping badly. She reported they had been this way all day, and the pain was driving her to tears. She immediately slathered the magnesium oil all over her hands. We were in report and she wanted it on her hands right away so the entire nursing staff watched and within 5 minutes you could visibly see her fingers extend back to normal and the finger movement return. We could literally see the relaxation taking place. It was simply amazing. Within minutes her hands were completely relaxed and functional again and stayed that way the remainder of the evening. She also applied the magnesium to her legs and found relief.

About 30 minutes after applying the oil, she held up her hands for everyone to see, and showed us the arthritic nodules on some fingers. She described how painful these always are to touch. But she poked and prodded them telling us how there was no pain now. She was able to continue working and doing the extensive writing that is a large part of our work without any further discomfort.

Pain relief and muscle relaxation for people with arthritis and muscle cramping is an important and significant benefit of magnesium oil. The rapid relief, visible to us all was really amazing! The following day she reported that she’d gotten the first restful night of sleep in many days. The pain was not waking her up.

What is essential to remember about treating pain with magnesium is that it treats both the symptom and the cause of pain. Meaning the cause of the pain can often be traced back to a magnesium deficiency.

There are not too many medicinal substances or medicines that can make this claim. It should be noted that pain management with magnesium employs magnesium chloride applied transdermally to the skin.

Dr. Linda Rapson, who specializes in treating chronic pain, believes that about 70 per cent of her patients who complain of muscle pain, cramps and fatigue are showing signs of magnesium deficiency. “Virtually all of them improve when I put them on magnesium,” says Rapson, who runs a busy Toronto pain clinic. “It may sound too good to be true, but it’s a fact.” She’s seen the mineral work in those with fibromyalgia, migraines and constipation. “The scientific community should take a good hard look at this.”[18]

Lynne Suo is one of Dr. Rapson’s patients. She had been using painkillers and steroids for years to try to ease the pain of her arthritis and fibromyalgia. Dr. Rapson started her on 675 units of magnesium a day. Within days, Suo called Dr. Rapson to report a surprising change. “I went from being in constant pain almost throughout the day and night to having moments of pain. And for me that was a huge improvement,” says Suo, a former college English teacher. She dismisses suggestions that the change is a placebo effect. “I was not one day without pain and now I don’t have to take heavy pain medication,” she reports.

The granddaddy of all anti-inflammatory drugs is aspirin, which can cause more serious problems than it often alleviates. Most pain and anti-inflammatory medications are not safe; even the over the counter pain medications hold unforeseen dangers. Despite more than a decade’s worth of research showing that taking too much acetaminophen can ruin the liver, the number of severe, unintentional poisonings from the drug is on the rise, a new study reports.[19] The drug, acetaminophen, is best known under the brand name Tylenol. Compounds containing Tylenol include Excedrin, Midol Teen Formula, Theraflu, Alka-Seltzer Plus Cold Medicine, and NyQuil Cold and Flu, as well as other over-the-counter drugs and many prescription narcotics, like Vicodin and Percocet.

People with poor quality sleep or sleep deprivation exhibit increased levels of interleukin-6 (IL6), the chemical that causes inflammation throughout the body. According to Dr. J. Durlach, the biological clock and magnesium status are linked, and a balanced magnesium status is important for the function of the mysterious pineal gland. Dr. Durlach sees the psycholeptic sedative effects of darkness amplified by magnesium. There probably is a strong relationship between melatonin and magnesium; certainly relative amounts of light and darkness affect the pineal gland and its production of melatonin. Magnesium provides a calming effect that allows for deeper relaxation and better sleep. Magnesium is considered the “antistress” mineral. It is a natural tranquilizer which functions to relax skeletal muscles as well as the smooth muscles of blood vessels and the gastrointestinal tract.

According to the National Sleep Foundation approximately 70 million people in the United States are affected with sleeping disorders. Approximately 12 million Americans have restless legs syndrome, a sleep and movement disorder characterized by unpleasant (tingling, crawling, creeping and/or pulling) feelings in the legs, which cause an urge to move in order to relieve the symptoms. Magnesium supplements may be helpful for relieving restless leg syndrome (RLS) and for treating insomnia.

Depression also is correlated with inflammation. A study conducted by researchers at the Emory University School of Medicine found that psychological stress leads to an excessive inflammatory response in people. Their findings published in the American Journal of Psychiatry showed that individuals who suffer from depression are more likely develop an inflammatory response due to the emotional disorder than people who are not depressed.[20] It should come as no surprise that magnesium supplementation has a great effect on depression.

In the final analysis there is no single medicine or nutritional agent that has the power to both treat and prevent chronic inflammatory conditions. Magnesium acts as a general cell tonic while it reduces inflammation and systemic stress. Equally it is important in overall energy (ATP) production, hormonal and enzyme production and function which all reflect powerfully on the process of inflammation.

Dr. Mark Sircus AC., OMD, DM (P)

References (20)

http://www.diabeteshealth.com/read/2008/01/13/5617.html

Am J Physiol. 1992;263:R734-7

http://www.time.com/time/magazine/article/0,9171,993419-1,00.html

Comstock G: Water hardness and cardiovascular diseases. Am J Epidemiol 1979; 110:375-400

Rubenowitz E, Axelsson G, Rylander R: Magnesium and calcium in drinking water and death from acute myocardial infarction in women. Epidemiology 1999; 10:31-36

Marx A, Neutra R: Magnesium in drinking water and ischemic heart disease. Epidemiol Rev 1997; 19:258-272

Mag Res. 1992:5:281-93

Magnesium and inflammation: lessons from animal models] Clin Calcium. 2005 Feb;15(2):245-8. Review. Japanese. PMID: 15692164 [PubMed – indexed for MEDLINE

http://www.prevention.com/cda/article/magnesium-chills-inflammation/ 9c9150d1fa803110VgnVCM10000013281eac____/health/healthy.living.centers/heart.conditions

Hautarzt. 1990;41:602-5

Mazur A, Maier JA, Rock E, Gueux E, Nowacki W, Rayssiguier Y. Magnesium and the inflammatory response: Potential physiopathological implications. Arch Biochem Biophys. 2006 Apr 19; PMID: 16712775Equipe Stress Metabolique et Micronutriments, Unite de Nutrition Humaine UMR 1019, Centre de Recherche en Nutrition Humaine d’Auvergne, INRA, Theix, St. Genes Champanelle, France.Arch Biochem Biophys. 2006 Apr 19 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt =Abstract&list_uids=16712775&itool=iconabstr&query_hl=2&itool=pubmed_docsum

Calderón-Garcidueñas L et al. Toxicol Pathol. 2008;36(2):289-310. Epub 2008 Mar 18 Instituto Nacional de Pediatría, Mexico City, Mexico. Air pollution is a serious environmental problem. We investigated whether residency in cities with high air pollution is associated with neuroinflammation/neurodegeneration in healthy children and young adults who died suddenly. We measured mRNA cyclooxygenase-2, interleukin-1beta, and CD14 in target brain regions from low (n = 12) or highly exposed residents (n = 35) aged 25.1 +/- 1.5 years. Upregulation of cyclooxygenase-2, interleukin-1beta, and CD14 in olfactory bulb, frontal cortex, substantia nigrae and vagus nerves; disruption of the blood-brain barrier; endothelial activation, oxidative stress, and inflammatory cell trafficking were seen in highly exposed subjects. Amyloid beta42 (Abeta42) immunoreactivity was observed in 58.8% of apolipoprotein E (APOE) 3/3 < 25 y, and 100% of the APOE 4 subjects, whereas alpha-synuclein was seen in 23.5% of < 25 y subjects. Particulate material (PM) was seen in olfactory bulb neurons, and PM < 100 nm were observed in intraluminal erythrocytes from lung, frontal, and trigeminal ganglia capillaries. Exposure to air pollution causes neuroinflammation, an altered brain innate immune response, and accumulation of Abeta42 and alpha-synuclein starting in childhood. Exposure to air pollution should be considered a risk factor for Alzheimer’s and Parkinson’s diseases, and carriers of the APOE 4 allele could have a higher risk of developing Alzheimer’s disease if they reside in a polluted environment. PMID: 18349428

Assessment of the relationship between hyperalgesia and peripheral inflammation in magnesium-deficient rats. Sophie Begona, Abdelkrim Allouia, Alain Eschaliera, André Mazurb, Yves Rayssiguierb and Claude Dubray, Pharmacologie Fondamentale et Clinique de la Douleur, Laboratoire de Pharmacologie Médicale, Faculté de Médecine, France

Magnesium and the inflammatory response: Potential physiopathological implications. Andrzej Mazura, Jeanette A.M. Maierb, Edmond Rocka, Elyett Gueuxa, Wojciech Nowackic and Yves Rayssiguiera. University of Milan, Department of Preclinical Sciences, Milan, Italy

Magnesium and inflammation: lessons from animal models] Clin Calcium. 2005 Feb;15(2):245-8. Review. Japanese. PMID: 15692164 [PubMed – indexed for MEDLINE

Alderman JD, Pasternak RC, Sacks FM, Smith HS, Monrad ES, Grossman W. Effect of a modified, well-tolerated niacin regimen on serum total cholesterol, high density lipoprotein cholesterol and the cholesterol to high density lipoprotein ratio. Am J Cardiol. 1989 Oct 1;64(12):725-9.

Orthomolecular Medicine News Service, August 11, 2008 Way Too Many Prescriptions

http://www.ctv.ca/servlet/ArticleNews/story/CTVNews/ 20020923/favaro_magnesium020923/CTVNewsAt11/story/

http://www.nytimes.com/2005/11/29/health/29cons.html?ei=5088&en= dcdd26e735aa717b&ex=1290920400&partner=rssnyt&emc=rss&pagewanted=print

http://news.softpedia.com/news/Depression- Causes-Excessive-Body-Inflammation-34499.shtml

Uses of Magnesium Oil

Magnesium Bicarbonate – The Ultimate Mitochondrial Cocktail

Become Your Own Cancer Expert

Important Magnesium Information

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naturopathytreatments · 5 years

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A Naturopathic Approach to Chronic Inflammation

How much do you know about treating chronic inflammation with naturopathy?

Here’s what you need to know about inflammation, how it’s connected to chronic diseases and how naturopathy can maximize good health and prevent chronic diseases.

What is Inflammation?

Inflammation is the body’s critical response to an injury, infection or stress (or a combination of all three). It works by signaling our body’s immune system to respond and repair injured and damaged tissues. An inflammatory messenger causes an injured area to have increased blood flow, bringing to this area additional nutrients and white blood cells to kick-start the healing process.

Inflammation is also in charge of blocking foreign invaders by defending the immune system from bacteria and viruses. It’s so important that without it, our wounds would get infected and our bodies would be vulnerable to deadly infections.

However, there are instances when inflammation becomes an issue. If the process of inflammation self perpetuates, this long-term inflammatory response – that could last for many months or years – can cause chronic inflammation-mediated complications.

So What is Chronic Inflammation?

Compared to acute inflammation, which is short-term, chronic inflammation can occur for a long period of time and drastically affect your body. This type of inflammation is also known as persistent low-grade inflammation since, as the name suggests, it affects the whole body with low levels of inflammation. Chronic inflammation can also play a role in the future development of diseases such as heart disease or stroke, and may also lead to autoimmune disorders, including rheumatoid arthritis, lupus, chronic pain and low quality of life.

With that, it’s important to watch out for symptoms of chronic inflammation such as the ones listed below to help prevent and reverse chronic diseases:

High blood glucose levels

Digestive problems, such as gas, diarrhea, bloating, constipation

Tired all the time

Skin problems (eczema, psoriasis, skin appears red and blotchy)

Puffy face or puffy bags under your eyes

Depression, anxiety or brain fog

What Triggers Chronic Inflammation?

First, let’s look at an on/off switch: when chronic inflammation forms, it means a switch in your immune system gets stuck to the ‘on’ setting, releasing harmful chemicals that affects the cells. (Think of a fire that never gets extinguished.) That said, some of these inflammation triggers include persistent infections, low gut health, food allergies, air pollution, nutrient deficiencies and an imbalance of omega-3s and omega-6s in your diet.

Using naturopathy to alleviate prolonged inflammation is a great first step in boosting your defense against many major diseases. Through this approach, you’re discovering the root causes of your inflammation and how you can help avoid and/or reduce it naturally.

Preventing Inflammation with Naturopathic Medicine

Naturopathy can be an ideal way to prevent or treat chronic inflammation because it encourages the body to heal itself through natural solutions. Regularly visiting a naturopathic doctor such as , ND in Toronto can help you address inflammatory triggers in your lifestyle and diet, all while building a plan to support your current and future health.

Through naturopathic medicine, you’ll discover that preventing inflammation can pay off in the long run; you’ll uncover how to restore vitality and reduce any risks for potential diseases. To get you started in your fight against inflammation, try these natural tips to cut down inflammation:

Reduce your intake of inflammatory foods. An anti-inflammatory diet may prevent or reduce inflammation, as well as any harmful effects associated with inflammation. Avoid refined carbohydrates, fried foods, sugary processed foods, and high-consumption dairy and animal products. Take note: Gut health has a distinct relationship with inflammation. Look at Leaky Gut Syndrome, for instance: undigested food and bacterial toxins leave the digestive system and move into your bloodstream; this triggers the immune system, causing ongoing inflammation. Not to mention, if pathogens get transferred into the blood, certain conditions may be triggered, including inflammatory bowel disease or rheumatoid arthritis.

Consume anti-inflammatory foods. Eat antioxidant-rich veggies and fruits, such as blueberries, kale, red cabbage and goji berries, to reduce some of the negative effects of inflammation. Consume foods with omega-3 fatty acids, like cold water fish and walnuts. Olive oil, herbal teas and ginger, rosemary and clove spices are also anti-inflammatory. Consider exploring anti-inflammatory diets such as the Mediterranean Diet. Because it stresses the importance of whole grains, good fats, fish, veggies and fruit, this diet is anti-inflammatory. The Mediterranean Diet also limits unhealthy fats (red meat, butter) and refined carbohydrates and sugars.

Control your blood sugar levels. Blood sugar spikes can be the cause of inflammation. Studies have revealed that ongoing spikes in insulin levels (due to high blood sugar levels) result in low-grade inflammation, obesity, and a resistance to insulin and higher gut permeability. An anti-inflammatory diet should be built around foods that don’t spike your blood sugar, such as lean proteins, whole foods high in fibre like vegetables, and whole grains like quinoa. And remember, limit or avoid simple carbohydrates and anything high in fructose corn syrup.

Introduce anti-inflammatory herbs into your daily regime. Studies have shown that turmeric and boswellia herbs are well-known anti-inflammatories. In some studies, turmeric has been found to be just as effective as ibuprofen when easing arthritis pain. And when you look at boswellia, it actually contains four acids that act as anti-inflammatories. Learn more about natural anti-inflammatories and pain medications here.

Avoid omega-6 fatty acids and trans fats. Did you know that when we eat a Western diet, we consume 20 times the number of omega-6s, in comparison to omega-3s? Cheaper foods, such as frozen foods, processed cakes and cookies, contain a lot of omega-6 and trans fatty acids. Unlike its healthier counterpart, which is omega-3 fatty acids found in fish oils and some nut oils, omega-6 fatty acids promote inflammation in our body. Meanwhile, omega-3 is anti-inflammatory.

Exercise regularly. Routine workouts are known to help prevent inflammation. Even a simple brisk walk and regular yoga classes can lead to a healthier status. Read more about the benefits of exercising here.

Manage stress. Much inflammation is caused by chronic stress. There are times we encounter stressful situations. We can’t always control when they happen, but we can learn how to respond to stress differently and manage our stress levels better. With that, explore meditation, yoga, acupuncture, biofeedback or guided imagery to help manage daily stressors.

Discuss IV therapy with a naturopathic doctor. Glutathione is an endogenous antioxidant and detoxifier that our body naturally makes. However, it’s been shown that stress, toxins and many health conditions are affiliated with depleted glutathione levels. Your body cannot properly absorb glutathione when you consume oral glutathione supplements, but IV therapy can help restore this antioxidant’s levels. IV glutathione treatments may help your body fight oxidative stress. In fact, your body may be protected from oxidative damage when you maintain normal glutathione levels. In some health conditions, including cancer, rheumatoid arthritis and diabetes, there is a link between low glutathione levels and high oxidative stress. Most of all, glutathione IV therapy may help control inflammation. In a 2009 study published in Autoimmunity Reviews, it was demonstrated that glutathione helps control inflammation by promoting or inhibiting immunological responses.

Customize your health plan now to support your well-being on a long-term basis. As a naturopathic doctor in Toronto, can help you identify and address potential inflammatory triggers within your diet and lifestyle. You may also inquire about how IV therapy can help reduce your inflammation. Click here to book your appointment at Dr. Amauri Wellness Centre.

The post “A Naturopathic Approach to Chronic Inflammation” was seen first on Dr. Amauri Caversan

Want to know more about the different naturopathic treatments? Dr. Amauri Caversan is a naturopathic service provider in Toronto, Ontario. Check him out: https://dramaurinaturopath.com/

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quintinefowler-blog · 6 years

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Natural Treatments for Bursitis

Bursitis is an inflammation of a bursa, a small structure inside every joint that helps to lubricate and cushion it.

Usually bursitis occurs in the larger joints, such as the shoulder, hip, knee, or elbow. It can happen once or can recur over time.

Without seeing your health care provider, you usually can't easily tell the difference between bursitis and pain caused by a strain or arthritis.

Signs and Symptoms

* Pain in the joint that gets worse when you move the joint (the pain may come all at once or develop gradually over time) * Swelling * Redness * Fever and warm joint area (if an infection is present)

Nutrition

Include in your diet anti-inflammatory oils such as those found in cold-water fish, nuts, and seeds. The following supplements may help.

* Glucosamine sulfate (500 mg two or three times a day), for connective tissue support * Omega-3 oils (1,000 mg two or three times a day), such as flaxseed oil, as an anti-inflammatory agent * Vitamin C with flavonoids (250 to 500 mg two times a day), for connective tissue repair * Proteolytic enzymes such as bromelain (250 mg twice a day), to reduce inflammation * Flavonoids and oral digestive enzymes for inflammation

Herbs

Herbs are generally a safe way to strengthen and tone the body's systems. As with any therapy, it is important to work with your provider on getting your problem diagnosed before you start any treatment. Herbs may be used as dried extracts (capsules, powders, teas), glycerites (glycerine extracts), or tinctures (alcohol extracts).

Unless otherwise indicated, teas should be made with 1 tsp. herb per cup of hot water. Steep covered 5 to 10 minutes for leaf or flowers, and 10 to 20 minutes for roots. Drink 2 to 4 cups per day. Tinctures may be used alone or in combination as noted.

* Herbs that reduce swelling include meadowsweet (Filipendula ulmaria), white willow (Salix alba), Jamaica dogwood (Piscidia piscipula), and turmeric (Curcuma longa). A tincture of one, or a combination of these, may be taken at 15 drops every 15 minutes up to four doses for acute pain relief, or 30 drops four times per day for general pain relief. Turmeric increases the effects of bromelain.

* For bursitis with muscle spasm, add valerian (Valeriana officinalis) .

* For chronic bursitis, add hawthorn (Crataegus monogyna).

Homeopathy

Some of the most common remedies are listed below. Usually, the dose is 3 to 5 pellets of a 12X to 30C remedy every one to four hours.

* Arnica gel applied topically (to the skin) as directed gives excellent short-term pain relief. * Arnica for bursitis occuring after an injury to the joint * Ruta graveolons for rheumatic pains in the joint * Bellis perennis for injury with a great deal of bruising * Rhus toxicodendron for pain that gets better with movement * “Traumeel” injections as an alternative to corticosteroids

Joint, muscles & connective tissue support

Helps comfort sore joints and muscles

Supports healthy cartilage and mobility

Promotes healthy inflammation management

Stage 1: Support cartilage function

Cartilage is the soft tissue padding between all joints and bones which acts like a shock absorber. After years of wear and tear – the amount of cartilage between joints can decline – and that can lead to stiff and painful joints. Not Just Joints contains a host of cartilage supporting nutrients including:

Glucosamine – to support healthy fluid levels around joints

Chondroitin – to help support the immune system in response to cartilage damage

Not Just Joints contains a broad range of synergistic ingredients that work together to support cartilage growth and function.

Stage 2: Supports healthy inflammation management

When cartilage erodes over an extended period of time, the prolonged immune response could lead to chronic inflammation, potentially triggering further conditions.

Cartilage has no blood supply, in fact it depends on a clean supply of synovial fluid for nutrients to travel. Not Just Joints supports the body’s healthy inflammation management process (also called immunomodulation) with a multi-faceted approach.

Stage 3: Manage the cycle of cartilage destruction

Chronic inflammation in the synovial membrane can trigger the production of more inflammatory compounds, which travel into the synovial fluid and then back into cartilage. This may cause further cartilage destruction – and even more chronic inflammation, becoming a vicious painful cycle.

Not Just Joints contains specialized natural agents that are rarely found in other natural joint formulas

Stage 4: Healthy joints and cartilage reduces the risk of “Bone-on-Bone” scraping

As cartilage deteriorates – you lose the protective space between bones – and that bone-on-bone scraping can trigger inflammation, pain and reduced mobility.

Not Just Joints helps to support:

The body’s ability to manage cartilage and glutathione depletion

Mobility

Healthy inflammation management

Comfort sore joints

Immune function and skin health

Learn more about Not Just Joints now.

Image courtesy of: By Uwe Gille (Self-published work by Uwe Gille) [GFDL, CC-BY-SA-3.0 or CC-BY-SA-2.5-2.0-1.0], via Wikimedia Commons

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koncptnext · 4 years

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MCQ of the Day- 15 sep

NEXT / EXIT / Latest NEET PG Pattern Q bank

1. A 20 -year-old boy sustained blunt trauma to the abdomen when the vehicle he was driving struck a bridge abutment at high speed. Peritoneal lavage shows a hemoperitoneum, and at laparotomy, a small portion of the left lobe of the liver is removed because of the injury. Several weeks later, a CT scan of the abdomen shows that the liver has nearly regained its size before the injury. Which of the following processes best explains this CT scan finding?

(A) Apoptosis

(B) Dysplasia

(D) Hyperplasia

CORRECT ANSWER : OPTION D : HYPERPLASIA.

Ref: Robbins and Cotran Pathologic Basis of Disease. SouthAsia Edition ,Volume I : Page 36

The question is regarding the adaptations of cell following injury.

Hyperplasia is increase in the number of cells in an organ or tissue in response to a stimulus.

The liver is one of the few organs in the human body that can partially regenerate. This is a form of compensatory physiological hyperplasia. Hyperplasia is the result of growth factor driven proliferation of mature surviving cells. The stimuli to hepatocyte mitotic activity cease when the liver has attained its normal size.

Option A : Apoptosis (INCORRECT). Apoptosis is programmed cell death. In certain viral infections, the loss of infected cells is due to apoptosis induced by the virus , frequently occurs in viral hepatitis.

Option B:Dysplasia (INCORRECT). Dysplasia is disordered epithelial cell growth that can be premalignant.

Option C: Fatty change. Fatty change can lead to hepatomegaly. This is not a regenerative process, but as a result of toxic hepatocyte injury.

2. A 50-year-old man, smoker, had undifferentiated carcinoma of the lung. Despite chemotherapy, the man died of widespread metastases. At autopsy, tumors were found in many organs. Histologic examination showed many foci in which individual tumor cells appeared shrunken and deeply eosinophilic. Their nuclei exhibited condensed aggregates of chromatin under the nuclear membrane. The process affecting these shrunken tumor cells was most likely triggered by the release of which of the following substances into the cytosol?

(A) Lipofuscin

(B) Cytochrome c

(D) Phospholipase

CORRECT ANSWER : OPTION B: CYTOCHROME C.

Ref: Robbins and Cotran Pathologic Basis of Disease. SouthAsia Edition ,Volume I : Page 55

This histologic picture- (cell shrinkage, deeply eosinophilic cytoplasm and chromatin condensation) is typical of apoptosis produced by chemotherapeutic agents.

The release of cytochrome c from the mitochondria into cytosol is a key step in many forms of apoptosis, and it leads to the activation of caspases.Release of cytochrome C is the initiator of apoptosis.

Option A : lipofuscin (INCORRECT). Lipofuscin is a pigmented residue representing undigested cellular organelles in autophagic vacuoles. Lipofuscin is a “wear-and-tear” pigment that increases with aging, particularly in liver and myocardiumand in patients with severe malnutrition. Histologically it appears as yellowbrown, finely granular cytoplasmic pigment.

Option C: BCL-2 (INCORRECT). BCL-2 is an antiapoptotic protein that prevents cytochrome c release by keeping mitochondrial outer membrane impermeable and prevents caspase activation.

Option D :Phospholipase (INCORRECT). Phospholipases are activated during necrosis. Phospholipase activation is calcium dependent and results in phospholipid breakdown → lipid breakdown products→ membrane damage.

3. A 71-year-old man diagnosed with pancreatic cancer is noted to have decreasing body mass index. His normal cells comprising skeletal muscle undergo atrophy by sequestering organelles and cytosol in a vacuole followed by fusion with a lysosome. However, the cancer continues to increase in size. Which of the following processes is most likely occurring in the normal cells but inhibited in the cancer cells of this man?

(A) Aging

(B) Apoptosis

(D) Hyaline change

CORRECT ANSWER : OPTION C : AUTOPHAGY

Ref: Robbins and Cotran Pathologic Basis of Disease. SouthAsia Edition ,Volume I : Page 60

The process of sequestration of organelles and followed by lysosomal fusion suggests autophagy.

Autophagy is a form of cellular downsizing in response to stress, as the cell eats its own contents by upregulating Atgs(autophagy related genes) genes. Cell death triggered by autophagy has different mechanism than apoptosis, a form of single cell necrosis in which cell fragmentation occurs.Cancer cells acquire the ability to avoid autophagy ,by downregulating PTEN gene expression, and maintain a survival advantage even as the patient is dying.Autophagy can promote cancer growth and acts as a defence against cancer.

Option A : Aging (INCORRECT). There is slow autophagy with aging, but autophagy is accelerated with stressors such as malnutrition and chronic disease.

Option B : Apoptosis (INCORRECT).apoptosis removes cells that are damaged beyond repair .

Option D : hyaline change (INCORRECT). Hyaline is a generic term for intracellular or extracellular protein accumulations appearing as homogenous glassy pink with H&E staining

4. A 38 year old man with his body mass index is <22 .He fully expects to live long because he has read that caloric restriction prolongs life.He has read that red wine promotes longevity and lifestyle modification promotes increased insulin sensitivity and glucose utilization In this man, which of the following proteins will most likely mediate the effect of calorie restriction upon increased longevity?

(A) Caspase

(B) Glutathione

(D) Telomerase

CORRECT ANSWER : OPTION C : SIRTUINS

Ref: Robbins and Cotran Pathologic Basis of Disease. SouthAsia Edition ,Volume I : Page 67

The one way for increased longevity is calorie restriction. Dietary excesses lead to increased morbidity with reduced quality of life, as well as mortality, from chronic diseases such as diabetes mellitus. The histone deacetylase activity of sirtuins may promote transcription of genes encoding for proteins that increase metabolic activity and inhibit effects of free radicals. Red wines have been shown to increase sirtuins when taken in moderate amounts.

Option A : caspase (INCORRECT). Caspases are the enzymes that trigger apoptosis and promotes cell death.

Option B : glutathione(INCORRECT) Glutathione promotes free radical breakdown, though chronic excessive alcohol consumption depletes hepatocyte glutathione.

Option D : telomerase(INCORRECT) Telomerases aid in promoting continued cell division, but cannot be altered by lifestyle, and turning them on is one feature of neoplasia.

5. A 40-year-old man has had midepigastric abdominal pain for the past 3 months. An upper gastrointestinal endoscopy shows a 2-cm, sharply demarcated, shallow ulceration of the gastric antrum. A biopsy specimen of the ulcer base shows angiogenesis, fibrosis, and mononuclear cell infiltrates with lymphocytes, macrophages, and plasma cells. Which of the following terms best describes this pathologic process?

(A) Acute inflammation

(B) Serous inflammation

(D) chronic inflammation

CORRECT ANSWER : OPTION D : CHRONIC INFLAMMATION.

Ref: Robbins and Cotran Pathologic Basis of Disease. SouthAsia Edition ,Volume I : Page 93

The clues for diagnosis – pain for 3 months and the histopathological findings characteristics of chronic inflammation is tissue destruction, mononuclear cell infiltration and healing (fibrosis and angiogenesis).Mononuclear cell infiltration includes macrophages and lymphocytes.

Chronic inflammation is one of the outcome of the acute inflammation.

Option A : acute inflammation (INCORRECT). In acute inflammation, the healing process of fibrosis and angiogenesis has not begun.Acute inflammation is characterised by vasodilatation and increased vascular permeability and leucocytes (predominantly neutrophils ) are recruited.

Option B : serous inflammation (INCORRECT). Serous inflammation is the mildest form of acute inflammation. A blister is a good example of serous inflammation. It is associated primarily with exudation of less protein fluid into the subcorneal or subepidermal space.

Option C: granulomatous inflammation (INCORRECT). Granulomatous inflammation is characterized by collections of transformed macrophages called epithelioid cell along with lymphocytes with central necrosis.It is a form of chronic inflammation

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amberwellnessgroup · 3 years

Link

Some simple practices in the kitchen to avoid, if you are feeling increased fatigue, allergy symptoms, or extra sensitive:

Fruit or veggies with brown spots (this is mold in the making, even cutting it off does not get rid of it all).

Leftovers that are more than 24 hours old will start creating more spores on the food and can increase your overall load.

High histamine foods

Fermented foods

Cured meats

Pickled foods

Learn more - https://www.amberwellnessgroup.com

#women wellness #men's wellness care #womens wellness care #children wellness care

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thesittingduck · 4 years

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Paracetamol Teva Uses, Dosage, Side Effects, Precautions

Drug Online

paracetamol teva english >> Generic drug of the therapeutic class: Analgesics active ingredients: Paracetamol

What is Paracetamol Teva?

This medicine contains paracetamol.

It is indicated in case of pain and / or fever such as headaches, flu, dental pain, body aches, painful periods.

This presentation is reserved for adults and children from 27 kg (approximately 8 years and over); read the section “Dosage” carefully.

For children weighing less than 27 kg, there are other presentations of paracetamol: ask your doctor or pharmacist for advice.

what is Paracetamol Teva medication used for and indication?

Symptomatic treatment of mild to moderate pain and / or febrile conditions.

Paracetamol Teva Dosage

Administration mode

Oral way.

The capsules are swallowed as is with a drink (eg water, milk, fruit juice).

Capsule taking is contraindicated in children under 6 years of age because it can lead to a wrong course. Use another form.

Dosage

This presentation is reserved for adults and children from 27 kg (approximately from 8 years old).

In children, it is imperative to respect the dosages defined according to the weight of the child and therefore to choose a suitable presentation. Approximate ages by weight are given for information.

The recommended daily dose of paracetamol is approximately 60 mg / kg / day, to be divided into 4 or 6 doses, approximately 15 mg / kg every 6 hours or 10 mg / kg every 4 hours.

For children weighing 27 to 40 kg (approximately 8 to 13 years), the dosage is 1 capsule 500 mg per dose, to be renewed if necessary after 6 hours, without exceeding 4 capsules per day.

For children weighing 41 to 50 kg (approximately 12 to 15 years), the dosage is 1 capsule 500 mg per dose, to be renewed if necessary after 4 hours, without exceeding 6 capsules per day.

For adults and children weighing more than 50 kg (from about 15 years), the usual dosage is 1 to 2 capsules at 500 mg per dose, to be renewed after 4 hours if necessary. minimum.

It is generally not necessary to exceed 3 g of paracetamol per day, or 6 capsules per day. However, in case of more intense pain, the maximum dosage can be increased up to 4 g per day, or 8 capsules per day.

Always respect an interval of 4 hours between catches.

Maximum recommended doses : see section Warnings and precautions for use .

Frequency of administration

Systematic catches prevent pain or fever oscillations:

· In children, they should be regularly spaced, including at night , preferably 6 hours , and at least 4 hours;

· In adults, they must be spaced at least 4 hours apart.

Renal failure

In case of severe renal insufficiency (creatinine clearance less than 10 ml / min), the interval between two doses will be at least 8 hours . The dose of paracetamol should not exceed 3 g per day, ie 6 capsules.

The lowest effective daily dose should be considered, not to exceed 60 mg / kg / day (not to exceed 3 g / day) in the following situations:

Adults under 50 kg,

Mild to moderate hepatocellular insufficiency,

Chronic alcoholism,

Chronic malnutrition,

Dehydration.

Contraindications

Hypersensitivity to paracetamol or to other constituents.

Hepatocellular insufficiency.

Due to the presence of sorbitol , this medication is contraindicated in cases of fructose intolerance.

How it works Paracetamol Teva

Pharmacotherapeutic group: OTHER Analgesics and Antipyretics -ANILIDES, ATC code: N02BE01.

Paracetamol has a central and peripheral mechanism of action.

Paracetamol Teva Side Effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Paracetamol Teva Side Effects

Very rarely reported side effects (they affect less than one in 10,000 users):

· Serious skin reactions (such as peeling of the skin which can rapidly spread very seriously to the whole body, destruction of the skin). It should immediately stop treatment , tell your doctor and never take medicines containing paracetamol.

Adverse reactions reported with undetermined frequency:

· A rash or redness of the skin or an allergic reaction that may manifest as sudden swelling of the face and neck or sudden discomfort with a drop in blood pressure. Stop taking the medication immediately, tell your doctor, and never take any medication containing paracetamol again.

· Biological changes requiring a blood test have been observed: abnormally low levels of certain white blood cells or certain blood cells such as platelets can result in bleeding nose or gums. In this case, consult a doctor ;

· Lesions in the liver.

Reporting of side effects

If you get any side effects, talk to your doctor or pharmacist. This also applies to any side effects that are not mentioned in this leaflet. You can also report side effects directly via the national reporting system: National Agency for the Safety of Medicines and Health Products (ANSM) and the network of Regional Pharmacovigilance Centers –

By reporting side effects, you can help provide more information on the safety of the medicine.

Paracetamol Teva Interactions

Taking paracetamol may interfere with the glucose-glucose oxidase-peroxidase assay at abnormally high concentrations.

Taking paracetamol may interfere with the determination of blood uric acid by the phosphotungstic acid method.

Associations subject to precautions for use

+ Oral anticoagulants

Risk of an increase in the effect of oral anticoagulant and haemorrhagic risk when taking paracetamol at maximum doses (4 g / d) for at least 4 days. Regular control of the INR. Possible adaptation of oral anticoagulant dosage during paracetamol treatment and after discontinuation.

Paracetamol Teva Warnings and Precautions

To avoid a risk of overdose:

· To check the absence of paracetamol in the composition of other drugs;

· Respect the maximum recommended doses.

Maximum recommended doses:

In children under 40 kg , the total dose of paracetamol should not exceed 80 mg / kg / day (see section 4.9);

In children between 41 and 50 kg , the total dose of paracetamol should not exceed 3 g per day (see section 4.9);

In adults and children over 50 kg , the total dose of PARACETAMOL SHOULD NOT EXCEED 4 GRAMS PER DAY .

The tablet or capsule is contraindicated in children under 6 years of age because it can lead to a miscarriage.

Precautions for use

In a child treated with 60 mg / kg / day paracetamol, the combination of another antipyretic is justified only in case of ineffectiveness.

Paracetamol should be used with caution in case of:

Weight <50kg;

Mild to moderate hepatocellular insufficiency;

Severe renal impairment (creatinine clearance ≤ 30 mL / min (see sections 4.2 and 5.2),

Chronic alcoholism;

Chronic malnutrition (low liver glutathione reserves).

In patients with depleted glutathione status, the use of paracetamol may increase the risk of metabolic acidosis;

· Dehydration.

· If acute viral hepatitis is found, the treatment should be discontinued.

INTERACTIONS WITH OTHER DRUGS AND OTHER FORMS OF INTERACTION

Interactions with paraclinical examinations

Taking paracetamol may interfere with the glucose-glucose oxidase-peroxidase assay at abnormally high concentrations.

Taking paracetamol may interfere with the determination of blood uric acid by the phosphotungstic acid method.

Associations subject to precautions for use

+ Oral anticoagulants

Paracetamol Teva Warnings and Precautions

Drive and use machines

Not applicable.

Paracetamol Teva and PREGNANCY / BREAST FEEDING / FERTILITY

Pregnancy

Studies in animals have not shown any teratogenic or foetotoxic effect of paracetamol.

Clinically, the results of epidemiological studies seem to exclude a particular malformative or fetotoxic effect of paracetamol.

As a result, paracetamol, under normal conditions of use, may be prescribed throughout pregnancy.

feeding

At therapeutic doses, administration of this drug is possible during breastfeeding.

what should i do if i miss a dose of zoloft Paracetamol Teva?

Do not take a double dose to make up for the single dose you forgot to take.

What happens if I overdose from Paracetamol Teva ?

In case of overdose or accidental poisoning, urgently call a doctor.

What is Forms and Composition?

COMPOSITION

Active substance

Paracetamol: 500 mg

For a capsule.

Other components

Mannitol, glycerol distearate, magnesium stearate.

Capsule shell: gelatin, titanium dioxide (E171), yellow iron oxide (E172), erythrosine (E127).

NOT’s

Edrug-online contains comprehensive and detailed information about drugs available in the medical field, and is divided into four sections:

general information:

Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles

Additional information:

General explanation about dealing with the medicine: how to take the medicine, the doses and times of it, the start and duration of its effectiveness, the recommended diet during the period of taking the medicine, the method of storage and storage, recommendations in cases for forgetting the dose and instructions to stop taking the drug and take additional doses.

Special warnings:

For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.

Side effects:

It treats possible side effects and drug interactions that require attention and its effect on continuous use.

The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.

The post Paracetamol Teva Uses, Dosage, Side Effects, Precautions appeared first on Drug Online.

from Drug Online https://bit.ly/2Q60eWF via Edrug Online from faculty of medicine https://bit.ly/3kRWBC6 via Faculty of Medicine

#medicines #including Allergy Medicines #Anemia #Antibiotic Medicines #Colds & Flu Medicines #Cough Me

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colinfitzpatrick · 4 years

Text

Paracetamol Teva Uses, Dosage, Side Effects, Precautions

Drug Online

paracetamol teva english >> Generic drug of the therapeutic class: Analgesics active ingredients: Paracetamol

What is Paracetamol Teva?

This medicine contains paracetamol.

It is indicated in case of pain and / or fever such as headaches, flu, dental pain, body aches, painful periods.

This presentation is reserved for adults and children from 27 kg (approximately 8 years and over); read the section “Dosage” carefully.

For children weighing less than 27 kg, there are other presentations of paracetamol: ask your doctor or pharmacist for advice.

what is Paracetamol Teva medication used for and indication?

Symptomatic treatment of mild to moderate pain and / or febrile conditions.

Paracetamol Teva Dosage

Administration mode

Oral way.

The capsules are swallowed as is with a drink (eg water, milk, fruit juice).

Capsule taking is contraindicated in children under 6 years of age because it can lead to a wrong course. Use another form.

Dosage

This presentation is reserved for adults and children from 27 kg (approximately from 8 years old).

The recommended daily dose of paracetamol is approximately 60 mg / kg / day, to be divided into 4 or 6 doses, approximately 15 mg / kg every 6 hours or 10 mg / kg every 4 hours.

For children weighing 27 to 40 kg (approximately 8 to 13 years), the dosage is 1 capsule 500 mg per dose, to be renewed if necessary after 6 hours, without exceeding 4 capsules per day.

For children weighing 41 to 50 kg (approximately 12 to 15 years), the dosage is 1 capsule 500 mg per dose, to be renewed if necessary after 4 hours, without exceeding 6 capsules per day.

For adults and children weighing more than 50 kg (from about 15 years), the usual dosage is 1 to 2 capsules at 500 mg per dose, to be renewed after 4 hours if necessary. minimum.

Always respect an interval of 4 hours between catches.

Maximum recommended doses : see section Warnings and precautions for use .

Frequency of administration

Systematic catches prevent pain or fever oscillations:

· In children, they should be regularly spaced, including at night , preferably 6 hours , and at least 4 hours;

· In adults, they must be spaced at least 4 hours apart.

Renal failure

The lowest effective daily dose should be considered, not to exceed 60 mg / kg / day (not to exceed 3 g / day) in the following situations:

Adults under 50 kg,

Mild to moderate hepatocellular insufficiency,

Chronic alcoholism,

Chronic malnutrition,

Dehydration.

Contraindications

Hypersensitivity to paracetamol or to other constituents.

Hepatocellular insufficiency.

Due to the presence of sorbitol , this medication is contraindicated in cases of fructose intolerance.

How it works Paracetamol Teva

Pharmacotherapeutic group: OTHER Analgesics and Antipyretics -ANILIDES, ATC code: N02BE01.

Paracetamol has a central and peripheral mechanism of action.

Paracetamol Teva Side Effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Paracetamol Teva Side Effects

Very rarely reported side effects (they affect less than one in 10,000 users):

Adverse reactions reported with undetermined frequency:

· Lesions in the liver.

Reporting of side effects

By reporting side effects, you can help provide more information on the safety of the medicine.

Paracetamol Teva Interactions

Taking paracetamol may interfere with the glucose-glucose oxidase-peroxidase assay at abnormally high concentrations.

Taking paracetamol may interfere with the determination of blood uric acid by the phosphotungstic acid method.

Associations subject to precautions for use

+ Oral anticoagulants

Paracetamol Teva Warnings and Precautions

To avoid a risk of overdose:

· To check the absence of paracetamol in the composition of other drugs;

· Respect the maximum recommended doses.

Maximum recommended doses:

In children under 40 kg , the total dose of paracetamol should not exceed 80 mg / kg / day (see section 4.9);

In children between 41 and 50 kg , the total dose of paracetamol should not exceed 3 g per day (see section 4.9);

In adults and children over 50 kg , the total dose of PARACETAMOL SHOULD NOT EXCEED 4 GRAMS PER DAY .

The tablet or capsule is contraindicated in children under 6 years of age because it can lead to a miscarriage.

Precautions for use

In a child treated with 60 mg / kg / day paracetamol, the combination of another antipyretic is justified only in case of ineffectiveness.

Paracetamol should be used with caution in case of:

Weight <50kg;

Mild to moderate hepatocellular insufficiency;

Severe renal impairment (creatinine clearance ≤ 30 mL / min (see sections 4.2 and 5.2),

Chronic alcoholism;

Chronic malnutrition (low liver glutathione reserves).

In patients with depleted glutathione status, the use of paracetamol may increase the risk of metabolic acidosis;

· Dehydration.

· If acute viral hepatitis is found, the treatment should be discontinued.

INTERACTIONS WITH OTHER DRUGS AND OTHER FORMS OF INTERACTION

Interactions with paraclinical examinations

Taking paracetamol may interfere with the glucose-glucose oxidase-peroxidase assay at abnormally high concentrations.

Taking paracetamol may interfere with the determination of blood uric acid by the phosphotungstic acid method.

Associations subject to precautions for use

+ Oral anticoagulants

Paracetamol Teva Warnings and Precautions

Drive and use machines

Not applicable.

Paracetamol Teva and PREGNANCY / BREAST FEEDING / FERTILITY

Pregnancy

Studies in animals have not shown any teratogenic or foetotoxic effect of paracetamol.

Clinically, the results of epidemiological studies seem to exclude a particular malformative or fetotoxic effect of paracetamol.

As a result, paracetamol, under normal conditions of use, may be prescribed throughout pregnancy.

feeding

At therapeutic doses, administration of this drug is possible during breastfeeding.

what should i do if i miss a dose of zoloft Paracetamol Teva?

Do not take a double dose to make up for the single dose you forgot to take.

What happens if I overdose from Paracetamol Teva ?

In case of overdose or accidental poisoning, urgently call a doctor.

What is Forms and Composition?

COMPOSITION

Active substance

Paracetamol: 500 mg

For a capsule.

Other components

Mannitol, glycerol distearate, magnesium stearate.

Capsule shell: gelatin, titanium dioxide (E171), yellow iron oxide (E172), erythrosine (E127).

NOT’s

Edrug-online contains comprehensive and detailed information about drugs available in the medical field, and is divided into four sections:

general information:

Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles

Additional information:

Special warnings:

For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.

Side effects:

It treats possible side effects and drug interactions that require attention and its effect on continuous use.

The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.

The post Paracetamol Teva Uses, Dosage, Side Effects, Precautions appeared first on Drug Online.

from Drug Online https://bit.ly/2Q60eWF via Edrug Online

#medicines #including Allergy Medicines #Anemia #Antibiotic Medicines #Colds & Flu Medicines #Cough Me

0 notes

jesseneufeld · 4 years

Text

All About NAC: Supplement Benefits, Side Effects, Dosages

What is NAC?

N-acetyl-cysteine, or NAC, is the stable, supplement form of the amino acid cysteine. Cysteine provides one of the most crucial backbones undergirding the body’s premier antioxidant: Glutathione.

Might this have other effects? Does glutathione do anything else?

It reduces reactive oxygen species down to less damaging metabolites.

It is the master detoxifier, a major line of defense against invading mutagenic, carcinogenic, and inflammatory agents.

It defends against glycation.

It controls hundreds of proteins in the body.

Instantly access our FREE download: Guide to a Healthy Gut

It protects against lung damage and maintains respiratory function, especially in the context of infectious respiratory diseases.1

It regulates glutamate levels in the brain, reducing over-excitation.

In other words, it does a lot. We should probably try to keep our levels up. If we don’t?

Well…

Low levels of glutathione have been linked to such disparate conditions as diabetes, tuberculosis, cancer, HIV, and aging.2 Heart failure patients tend to have low glutathione.3 Low glutathione levels are generally associated with elevated markers of inflammation, like CRP.

Okay, so glutathione is important, low levels are linked to many different diseases and health conditions, it’s a good idea to have adequate levels for general health, and NAC is one of the better ways to replenish glutathione.4 At normal doses of Tylenol, taking NAC along with it prevents glutathione depletion without negatively affecting the therapeutic effect of the drug.5

Detoxification with NAC

In workers with chronic lead exposure, NAC increases antioxidant capacity in red blood cells, reduces oxidative stress, and lowers blood levels of lead.7

In adults with acute pesticide poisoning, NAC (600 mg 3 times per day) reduces inflammatory markers and the need for atropine (a pharmaceutical that treats pesticide poisoning).8

After exposure to diesel fumes, taking NAC reduces blood vessel damage and, in asthmatic patients, lowers the airway responsiveness.910

NAC even reduces the toxic effects in people who eat poison mushrooms or get dosed with mustard gas.1112

If large doses of NAC can help people deal with serious toxin loads, moderate doses of NAC can probably help people deal with normal loads.

NAC and Lung Health

The result is that bronchitis patients who take NAC over the course of 3-6 months experience lower rates of “exacerbations” (worsening episodes) and see their symptoms improve.13 Same goes for COPD patients on a year-long course of NAC; they enjoy improved lung capacity.14

Flu Resistance

One study in older adults had some remarkable results.15 Subjects were randomized to one of two groups. The first group got placebo. The second group got 600 mg of NAC, twice a day, for 6 months. Over the course of the study, they tracked “influenza-like” symptoms, finding that the NAC group had far fewer than the placebo group. Then they tested the subjects for influenza antibodies and found that both groups had equal seroconversion rates. Both groups were equally likely to have gotten the flu over the 6 months, but just 25% of the infected NAC group ever showed symptoms versus 79% of the infected placebo group who showed symptoms.

NAC Reduces Inflammation and Oxidative Stress

Increased oxidative stress is the baseline for too many people, and NAC has been shown to be one of the best “all-purpose” supplements for reducing it.16

Mental and Psychological Health

NAC smoothes that out. It sticks glutamate where it belongs in the right concentrations. It provides the right amount of inhibition to counter the excitation.17

NAC and Fertility

Both male and female infertility often come down to elevated oxidative stress. Can NAC reduce stress? Yes. Can NAC improve fertility? Yes.

In men visiting a fertility clinic, an NAC supplement (600 mg/day for 3 months) increased serum antioxidant capacity, reduced oxidative stress, and improved sperm quality, motility, and consistency.19

A combo of selenium and NAC was also able to improve semen quality in men with fertility issues.20

Should Everyone Take NAC?

Not necessarily. Most of its benefits occur in people with depleted glutathione levels and/or elevated inflammatory status.

One paper found that NAC was only helpful in patients with depleted glutathione levels.23 Those with low glutathione saw platelet function improvements, while those patients with normal glutathione levels saw no improvements in their platelet function.

Another paper found similar results with depression. Only those patients with elevated CRP levels at baseline experienced a reduction in depressive symptoms after taking NAC.24

You may not have the glutamate over-excitation issues of someone with full-blown schizophrenia or social anxiety disorder, but a little NAC might help you focus or improve your internal self-talk.

You may not have COPD, but making sure your lung glutathione stores are replete isn’t a bad idea.

You’re probably not completely infertile, but reducing oxidative stress and improving sperm or endometrial quality never hurt anyone’s chances.

What’s a Good NAC Dosage?

Many of the therapeutic effects used in the studies I referenced today were in the 500-600 mg range. Sometimes higher, but not necessarily.

That’s it for NAC, folks. If you have any questions or comments, drop them down below.

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References

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2129149/[ref] But does taking a NAC supplement actually improve health?

Let’s look at the evidence.

NAC Benefits

What areas of health can you expect to benefit from NAC supplementation?

Liver support

Detoxification

Lung health

Flu resistance

Inflammation and oxidative stress

Mental and psychological health

Fertility

NAC and Liver Support

NAC protects the liver against acetaminophen (Tylenol) toxicity, keeping liver enzyme levels down.[ref]https://ift.tt/35rjkxH

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