#anti A*chie Andrews

[djgrannyglasses]

On a list of leads that are the worst part of their show 👏👏

[arsenicpanda]

I think Archie got some much needed character development and now he’s matured. He’s never been a flashy character but he always does what’s right and for once he has learned to be open about his traumas and what he wants his life to be like. I like him so much more in these later seasons.

See, I think someone's patience for Archie, especially from s3b or 4 onward, is inversely proportional to how much harem anime (and anime with a side of harem elements) that person has suffered through, because Archie really turns into someone whose personality is Protagonist and then who is romantically tied to two girls who he switches between with no hesitation or thought, and he's just such a potato-kun at this point. Like, I could throw a rock and hit like five guys just like him in anime, and I am tired.

[bugheadchemistry]

“Fulfilling their destiny”? Didn’t she just help kill him, lol? After he acted like a dick basically brushing Betty off saying he didn’t want to adopt because he wants a bio child or whatever? I’d kill him too. Insert GOOD FOR HER gif. Whatever destiny they are fulfilling, it won’t be a good one. I’m exhausted by this.

I think we are all exhausted. The only people who seem to like what the show is doing right now are the b/as and they really shouldn’t. I didn’t watch the premiere (and will not watch another episode until Bughead is back), but there were so many people celebrating A*chie’s “death” that it was hilarious. You know you’re doing something wrong when so many people hate the “lead” character.

[mrscolesprouse]

okay leggo

god anytime i see archie’s face i just wanna punch him

[deans-haunted-baby]

So Archie's gonna be farting around on a farm with another older woman *eek*. Veronica is falling into underaged/illegal gambling with Reggie. B/tty's getting another lame angst arc. And Jughead's going full psycho. WTF is this stupid show anymore?

[cancersfakianakis1]

Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1

Publication date: 12 February 2018 Source:Cancer Cell, Volume 33, Issue 2 Author(s): Chia-Wei Li, Seung-Oe Lim, Ezra M. Chung, Yong-Soo Kim, Andrew H. Park, Jun Yao, Jong-Ho Cha, Weiya Xia, Li-Chuan Chan, Taewan Kim, Shih-Shin Chang, Heng-Huan Lee, Chao-Kai Chou, Yen-Liang Liu, Hsin-Chih Yeh, Evan P. Perillo, Andrew K. Dunn, Chu-Wei Kuo, Kay-Hooi Khoo, Jennifer L. Hsu, Yun Wu, Jung-Mao Hsu, Hirohito Yamaguchi, Tzu-Hsuan Huang, Aysegul A. Sahin, Gabriel N. Hortobagyi, Stephen S. Yoo, Mien-Chie Hung Protein glycosylation provides proteomic diversity in regulating protein localization, stability, and activity; it remains largely unknown whether the sugar moiety contributes to immunosuppression. In the study of immune receptor glycosylation, we showed that EGF induces programmed death ligand 1 (PD-L1) and receptor programmed cell death protein 1 (PD-1) interaction, requiring β-1,3-N-acetylglucosaminyl transferase (B3GNT3) expression in triple-negative breast cancer. Downregulation of B3GNT3 enhances cytotoxic T cell-mediated anti-tumor immunity. A monoclonal antibody targeting glycosylated PD-L1 (gPD-L1) blocks PD-L1/PD-1 interaction and promotes PD-L1 internalization and degradation. In addition to immune reactivation, drug-conjugated gPD-L1 antibody induces a potent cell-killing effect as well as a bystander-killing effect on adjacent cancer cells lacking PD-L1 expression without any detectable toxicity. Our work suggests targeting protein glycosylation as a potential strategy to enhance immune checkpoint therapy.

Teaser

Li et al. show that glycosylation of PD-L1 is essential for PD-L1/PD-1 interaction and immunosuppression in triple-negative breast cancer (TNBC). They generate a glycosylation-specific antibody that induces PD-L1 internalization and an antibody-drug conjugate with potent anti-tumor activities in TNBC models. http://ift.tt/2G7IeUY

[drasifshahid-blog]

Hong Kong 'Ten Years' film to get Japan, Thai spin-offs

Cast and crew from the controversial Hong Kong film "Ten Years" at a red carpet event in the Chinese city in April, 2016.

Busan (South Korea) - A controversial award-winning film that shook up Hong Kong with its bleak visions of the city's future is to be turned into a pan-Asian franchise, with Japanese, Taiwanese and Thai versions in the works. The original "Ten Years" movie was a collection of short films imagining how life might be in Hong Kong in 2025. Seen as a thinly veiled warning about life under Beijing's rule -- including diminished human rights and widespread censorship -- the film was banned on the mainland but was a critical success, with screenings around the world. Speaking at the official launch of the new project, Taiwanese director Rina B. Tsou said the next batch of filmmakers involved were ready to ride out any political storms the spin-offs might stir up. "It will be a challenge for us to put [society's] hidden dangers and hidden fears into film," Tsou, one of five Taiwanese directors attached to that version of the project, told the 22nd Busan International Film Festival (BIFF). The original "Ten Years" (2015) comprised five short films by emerging filmmakers that painted a gloomy view of how life might be in Hong Kong a decade later, 28 years after the former British colony had reverted to Chinese sovereignty. Segments imagined taxi drivers being banned from speaking in their native Cantonese, self-immolation becoming a form of protest against increased Chinese influence and pro-Beijing "youth guards" patrolling the streets. - Pollution, virtual reality and surveillance - In a statement released Monday, the filmmakers explained the Japanese version would explore a country "plagued by pollution and ageing" as well as a "society where morality and personal history are manipulated by technology." The film on Thailand, a country currently ruled by the military, would explore "issues of surveillance and government control" while Taiwan's would paint a picture of an island where "immigrant workers are systematically exploited and the loss of culture and dropping birth rate" have caused its inhabitants to turn to "virtual reality escapes." The original idea for "Ten Years" was conceived during the pro-democracy Umbrella Movement that brought the central business district of Hong Kong to a standstill for 79 days in 2014. "Ten Years" was named Best Film at the 35th Hong Kong Film Awards in 2016 after a release that was cloaked in controversy, with accusations that theatre owners had been strong-armed into pulling the film from general release due to its strong anti-Chinese sentiments. The fact that it was granted the city's top film award also seemed to divide the domestic industry, with calls to alter the voting methods used to decide that honour as well as arguments over the artistic merits of the film, made on a shoestring budget by inexperienced directors. Regardless, the film sold out whenever and where ever it screened –- including showings held in public spaces and against the sides of buildings. Hong Kong-based filmmaker Andrew Choi helped get the original "Ten Years" made and is back as an executive producer for the franchise. He said the plan was to try to take the project to as many Asian markets as possible. "The original Ten Years was created during a time of big changes in Hong Kong," said Choi. "We never imagined it would have such a big impact. With the new project we want to stimulate discussion about the future of each country." - 'I embrace it' - Acclaimed Japanese arthouse filmmaker Hirokazu Kore-eda –- long a favourite at the likes of the prestigious Cannes festival -– has come onboard as an executive producer and said at Monday's official project launch that he hoped the film would help younger Japanese filmmakers find their voice. "I hope they can look at the current situation in Japan and how we are accepting the future," said Kore-eda. Japanese director Chie Hayakawa, one of five Japanese directors signed on, said the original production had shown her the "power of film". Meanwhile, Thai director Aditya Assarat said he was aware of the controversy that surrounded the original release in 2015. "But I embrace it," he said. "I look forward to talking about politics which has been difficult to do in Thailand over the past 10 years." BIFF continues until October 21.

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[djgrannyglasses]

I treat the Varchie relationship much like you treat the relationship of a good friend where the man is kind of a putz but you just want your friend to be happy so you’re supportive of it.

[djgrannyglasses]

“You know what, Arch, you’re not that smart.”

finally somebody said it.

[djgrannyglasses]

Here is the thing if Betty doesn’t appear to have any interest in Jughead and fully into A*chie and Jughead has been writing this whole universe don’t you think those might have a connection. A*chie has always been a thorn in Jughead’s side and then Betty cheated on him with A*chie in high school don’t you think this may be his POV?

[djgrannyglasses]

Face it Betty could take her dream job and get married but it would probably require Archie to have to care for the kids and or leave Riverdale and that’s not part of the American dream.

[djgrannyglasses]

Pickens: *makes some valid points, with some not so great solutions*

A*chie, a middle class boy: LET'S GO FIGHT. ME NO HAVE BRAIN.

Jughead: I have ideas.

A*chie: I have an idea!

Town: great job, A*chie!

[djgrannyglasses]

Not A*chie having the audacity to call Jughead a backstabber.

[djgrannyglasses]

Rivervale (2021)

[djgrannyglasses]

I was thinking something, the whole conversation between Betty and Tabitha saying the hardest thing she had to do in high school was choosing between A*chie and Jughead. It kind of reminds me of Season 1 in the finale where A*chie started to say he thought he always though he and Betty would end up together. Which kind of leads me to believe this might be an A*chie coma thing.

[djgrannyglasses]

Since I keep getting this ask, I’m going to answer this without a smartass answer. Why do I want Bughead together if I “criticize”Betty? Because I like Betty when she is with Jughead because she’s herself. She’s not this watered down OOC Betty she has to be with A*chie.

Like she’s kind of dull with it’s not her fault it’s the writers. ✌🏼✌🏼✌🏼✌🏼