#downstream processing size

[luckydige45]

According to Statifacts, the U.S. downstream processing market size is calculated at USD 14,880 million in 2025 and is expected to reach around USD 49,940 million by 2034, growing at a CAGR of 14.4% from 2025 to 2034. 

[industrynewsupdates]

Downstream Processing Market: Key Trends and Growth Opportunities

The global downstream processing market size is expected to reach USD 94.79 billion by 2030, according to a new report by Grand View Research, Inc. The market is expected to expand at a CAGR of 14.84% from 2023 to 2030.  The capacity requirements during the development of biologic drugs have changed over the past few years, wherein the demand for manufacturing high-volume products has shifted to developing small-volume, high-potency products. This creates new avenues for single-use technologies. A rise in the utilization of downstream processing techniques for the development of COVID-19 vaccines is a significant factor driving the market. The adoption of small-scale, single-use systems for process development and downstream processing is already high.

Thus, evolutionary changes are expected in the area of single-use technologies for manufacturing small-volume, highly-potent drugs. The development of novel film chemistries, closed systems, automation in clinical-scale single-use systems, and smart sensors are some noteworthy advancements in the field. A rise in applications of downstream processing for the production of biopharmaceuticals is expected to bring growth opportunities to the market. This has also led to an increase in strategic deals and development in the market. For instance, in February 2021, Evozyne, LLC collaborated with a leading rare disorders drug manufacturer for the production and marketing of novel biopharmaceuticals for immune modulation.

Key players are investing in the bioprocessing of vaccines and therapies for COVID-19 to increase their market share. For instance, in May 2022, Lonza and ALSA Ventures are partnering to provide biotech firms with development and manufacturing services. In May 2022, Lonza added Titanium Dioxide-free white hard gelatin capsules to its Capsugel Capsule Line. The new capsule includes an alternative opacifying technology that provides a good masking solution as well as enhanced light protection for the fill formulation. In December 2021, Repligen bought Newton, New Jersey-based BioFlex Solutions. The purchase adds to and enhances Repligen’s single-use fluid management product line, as well as simplifies its supply chain. The integration of BioFlex Solutions strengthens its system offering by further integrating components and assemblies.

Gather more insights about the market drivers, restrains and growth of the Downstream Processing Market

Downstream Processing Market Report Highlights

• The chromatography systems segment dominated the market for downstream processing and accounted for the largest revenue share of 41.29% in 2022

• The advent of single-use chromatography systems that bring an 80.0% reduction of the use of water and chemicals for buffer has further increased the adoption of chromatography for downstream processing of bio-therapeutics

• Filters are anticipated to grow at a lucrative rate over the forecast period. Efforts undertaken by the key players to develop intelligent membranes for purification & separation is fuelling the market growth

• Purification by chromatography accounted for the largest revenue share as it can be employed across all steps of a downstream process. The technique is also crucial in bioprocessing to obtain pure biologics

• The antibiotic production segment dominated the market for downstream processing and generated the largest revenue share of 32.48% in 2022 owing to the wide applications of antibiotics for the treatment of several disorders.

• A rise in occurrences of antibiotic resistance also propels the industrial-scale development of novel antibiotic candidates

• North America dominated the market for downstream processing with the largest revenue share of 34.57% in 2022 owing to government support for promoting bioprocess technologies, rising medical expenditure, and developed healthcare infrastructure.

• Asia Pacific expected to register the highest growth rate of 15.67% during 2023-2030 due to a rise in contract development services in emerging economies

Downstream Processing Market Segmentation

Grand View Research has segmented the global downstream processing market based on product, technique, application, and region:

Downstream Processing Product Outlook (Revenue, USD Billion, 2018 - 2030)

• Chromatography Systems

• Filters

• Evaporators

• Centrifuges

• Dryers

• Others

Downstream Processing Technique Outlook (Revenue, USD Billion, 2018 - 2030)

• Cell Disruption

• Solid-liquid separation

o Filtration

o Centrifugation

• Concentration

o Evaporation

o Membrane filtration

• Purification by Chromatography

• Formulation

Downstream Processing Application Outlook (Revenue, USD Billion, 2018 - 2030)

• Antibiotic Production

• Hormone Production

• Antibodies Production

• Enzyme Production

• Vaccine Production

Downstream Processing Regional Outlook (Revenue, USD Billion, 2018 - 2030)

• North America

o U.S.

o Canada

• Europe

o Germany

o U.K.

o France

o Italy

o Spain

o Denmark

o Sweden

o Norway

• Asia Pacific

o Japan

o China

o India

o South Korea

o Thailand

o Australia

• Latin America

o Brazil

o Mexico

o Argentina

• Middle East and Africa (MEA)

o South Africa

o Saudi Arabia

o UAE

o Kuwait

List of Key Players of Downstream Processing Market

• Merck KGaA

• Sartorius Stedim Biotech S.A

• GE Healthcare

• Thermo Fisher Scientific Inc.

• Danaher Corporation

• Repligen

• 3M Company

• Boehringer Ingelheim International GmbH

• Corning Corporation

• Lonza Group Ltd

• Dover Corporation

• Ashai Kasei

• Ferner PLC

• Eppendorf AG

Order a free sample PDF of the Downstream Processing Market Intelligence Study, published by Grand View Research.

[laxmandige05]

In the rapidly growing field of global downstream Processing Market size was valued at USD 36.96 billion in 2023 and is projected to reach USD 131.05 billion by 2032, growing at a CAGR of 15.1% from 2023 to 2032 according to a new report by Nova One Advisor.

[marketreports-blog]

The global downstream processing market reached USD 32.11 Billion in 2022 and is projected to surpass around USD 131.05 Billion by 2032, expanding at a CAGR of 15.1% between 2023 and 2032.

[ramkumarss]

Downstream Processing Market size was estimated at USD 23.9 billion in 2022 and is expected to expand at a compound annual growth rate (CAGR) of 15.6% from 2023 to 2029. Downstream processing is the process of recovery and purification of the biosynthetic products. Biosynthetic products particularly pharmaceuticals, from natural sources such as plant or animal tissue or fermentation broth. Downstream processing market may also include recycling of salvageable components and proper treatment of waste. Furthermore, downstream processing is important step in manufacturing of hormones, antibiotics, antibodies, and vaccines. Stages include removal of insoluble, product isolation, product purification, product polishing and few recovery methods may be considered. The market is expected to grow at significant rates owing to the rise in demand for biopharmaceutical products. The market is consolidated due to presence of the many companies competing with product innovations and advancements. Companies are focusing on the R&D and new product launches to increase their product portfolio.

[desaletushki]

Downstream Processing Market Size, Share & Trends Analysis Report, 2030

The global downstream processing market size is expected to reach USD 94.79 billion by 2030, according to a new report by Grand View Research, Inc. The market is expected to expand at a CAGR of 14.84% from 2023 to 2030.  The capacity requirements during the development of biologic drugs have changed over the past few years, wherein the demand for manufacturing high-volume products has shifted to developing small-volume, high-potency products. This creates new avenues for single-use technologies. A rise in the utilization of downstream processing techniques for the development of COVID-19 vaccines is a significant factor driving the market. The adoption of small-scale, single-use systems for process development and downstream processing is already high.

Thus, evolutionary changes are expected in the area of single-use technologies for manufacturing small-volume, highly-potent drugs. The development of novel film chemistries, closed systems, automation in clinical-scale single-use systems, and smart sensors are some noteworthy advancements in the field. A rise in applications of downstream processing for the production of biopharmaceuticals is expected to bring growth opportunities to the market. This has also led to an increase in strategic deals and development in the market. For instance, in February 2021, Evozyne, LLC collaborated with a leading rare disorders drug manufacturer for the production and marketing of novel biopharmaceuticals for immune modulation.

Request a free sample copy or view the report summary: https://www.grandviewresearch.com/industry-analysis/downstream-processing-market

Key players are investing in the bioprocessing of vaccines and therapies for COVID-19 to increase their market share. For instance, in May 2022, Lonza and ALSA Ventures are partnering to provide biotech firms with development and manufacturing services. In May 2022, Lonza added Titanium Dioxide-free white hard gelatin capsules to its Capsugel Capsule Line. The new capsule includes an alternative opacifying technology that provides a good masking solution as well as enhanced light protection for the fill formulation. In December 2021, Repligen bought Newton, New Jersey-based BioFlex Solutions. The purchase adds to and enhances Repligen’s single-use fluid management product line, as well as simplifies its supply chain. The integration of BioFlex Solutions strengthens its system offering by further integrating components and assemblies.

Downstream Processing Market Report Highlights

The chromatography systems segment dominated the market for downstream processing and accounted for the largest revenue share of 41.29% in 2022

The advent of single-use chromatography systems that bring an 80.0% reduction of the use of water and chemicals for buffer has further increased the adoption of chromatography for downstream processing of bio-therapeutics

Filters are anticipated to grow at a lucrative rate over the forecast period. Efforts undertaken by the key players to develop intelligent membranes for purification & separation is fuelling the market growth

Purification by chromatography accounted for the largest revenue share as it can be employed across all steps of a downstream process. The technique is also crucial in bioprocessing to obtain pure biologics

The antibiotic production segment dominated the market for downstream processing and generated the largest revenue share of 32.48% in 2022 owing to the wide applications of antibiotics for the treatment of several disorders.

A rise in occurrences of antibiotic resistance also propels the industrial-scale development of novel antibiotic candidates

North America dominated the market for downstream processing with the largest revenue share of 34.57% in 2022 owing to government support for promoting bioprocess technologies, rising medical expenditure, and developed healthcare infrastructure.

Asia Pacific expected to register the highest growth rate of 15.67% during 2023-2030 due to a rise in contract development services in emerging economies

Downstream Processing Market Segmentation

Grand View Research has segmented the global downstream processing market based on product, technique, application, and region:

Downstream Processing Product Outlook (Revenue, USD Billion, 2018 - 2030)

Chromatography Systems

Filters

Evaporators

Centrifuges

Dryers

Others

Downstream Processing Technique Outlook (Revenue, USD Billion, 2018 - 2030)

Cell Disruption

Solid-liquid separation

Filtration

Centrifugation

Concentration

Evaporation

Membrane filtration

Purification by Chromatography

Formulation

Downstream Processing Application Outlook (Revenue, USD Billion, 2018 - 2030)

Antibiotic Production

Hormone Production

Antibodies Production

Enzyme Production

Vaccine Production

Regional Insights

North America dominated the market for downstream processing with the largest revenue share of 34.57% in 2022 owing to government support for promoting bioprocess technologies, rising medical expenditure, and developing healthcare infrastructure. In addition, the region has witnessed major collaborative activities with healthcare giants that are extensively investing in the R&D of biopharmaceuticals and vaccines. In addition, key players operating in the market for downstream processing are expanding their foothold in this region. For instance, Thermo Fisher Scientific Inc. recently announced a USD 97 million investment to extend its clinical research facilities in Richmond, Virginia. The facilities, which comprise laboratory operations obtained with the acquisition of PPD, Inc. in December 2021, will meet the growing need for consistent, greater laboratory services in biopharma to advance drug development.

In the Asia Pacific, the market for downstream processing is expected to register the highest growth rate of 15.67% during 2023-2030 due to the rising investments by developers and consumers in the field of biotechnology. The presence of a large population base is driving the need for advanced medical facilities for which players are keen on implementing rapid analytical methods to support in-process designing and bioprocessing. China dominated the market share in the Asia Pacific owing to the growing biopharmaceutical industry and increasing demand for medicines and vaccines. The biopharmaceutical industry is amongst the most active economic sectors in China and is marked by continuous revolution with modern biopharmaceutical equipment and process. For instance, in April 2021, Asahi Kasei Corporation, a solution supplier to the biologics manufacturing sector, extended its operations in China with the establishment of Asahi Kasei Bioprocess Co., Ltd. By localizing inventory management and order processing for faster delivery periods, the introduction of AKBC facilitates company development in China.

List of Key Players in the Downstream Processing Market

Merck KGaA

Sartorius Stedim Biotech S.A

GE Healthcare

Thermo Fisher Scientific Inc.

Danaher Corporation

Repligen

3M Company

Boehringer Ingelheim International GmbH

Corning Corporation

Lonza Group Ltd

Dover Corporation

Ashai Kasei

Ferner PLC

Eppendorf AG

Authoritative Research: https://www.grandviewresearch.com/industry-analysis/downstream-processing-market

[rjzimmerman]

Excerpt from this story from Inside Climate News:

Sheldon Auto Wrecking is a local institution in southwestern Wisconsin’s Vernon County. It’s tucked in a lush valley just downstream of a 50-foot earthen dam, locally known as “Maple Dale.” 

The salvage yard, which buys used vehicles and farm machinery in this rural area to sell for parts, has been in business for nearly 70 years. For most of those years, the dam—less than a half-mile up the road—has protected its yard of hundreds of old cars and broken-down equipment from frequent and sometimes severe flooding in the area.

The dam “was put in place for a reason,” said owner Greg Sheldon.

But it might soon go away. 

Maple Dale is one of thousands of dams constructed by the U.S. Department of Agriculture’s Natural Resources Conservation Service, beginning in the mid-20th century, for the purposes of flood control. 

In 2018, five similar dams in the region failed during a massive rainstorm that caused property damage in the tens of millions of dollars. A study determined that several other dams in the watersheds hit hardest by the flood, including Maple Dale, were also vulnerable to failure but would be too expensive to replace. 

As a result, local officials are voting on whether to dismantle the dams by cutting large notches in them, allowing the water to flow again, in a process called decommissioning. Experts say it could be the most dams ever decommissioned in a single county in the U.S. 

And it could be a harbinger for other communities.

Although the county may be the first to take on a project of this size, it’s unlikely to be the last. Dams across the country are aging, and also facing pressures from urban sprawl and intensifying floods wrought by climate change. The price tag to fix what’s broken, though, is estimated in the hundreds of billions of dollars, meaning dam owners could face hard questions about what to do with them. 

In Viroqua, it’s also leaving the people who own property below the dams uneasy about what comes next—including Sheldon.

“To come along and just rip a big hole out and let the water run is a mistake,” he said.

Removal Plan Controversial

The southwest Wisconsin dams are among nearly 12,000 that have been built under the USDA’s Watershed Programs. Generally smaller and set in rural agricultural areas, they’re mostly clustered from the center of the country eastward. Oklahoma has the most, followed by Texas, Iowa and Missouri. 

The idea for the watershed program dams arose during the Dust Bowl in the 1930s. Because there was little vegetation left on the landscape to soak up rain when it fell, there were several severe floods during that time, prompting federal agencies to look for a way to control the water. 

To get the dams built, the Natural Resources Conservation Service entered into a contract with a local sponsor, such as a county. NRCS covered all the construction costs and helped the sponsor with inspections and repairs. In return, the sponsor maintained the dam for a certain number of years—under most contracts, 50—to ensure taxpayers got their money’s worth out of the project. 

Since many of the dams were built in the 1960s and 1970s, said Steve Becker, Wisconsin’s state conservation engineer for NRCS, their contracts are now up. 

“We pretty much told the counties, ‘You have full autonomy to do whatever you want with those dams,” Becker said. “You can maintain, you can rehab, you can repair. It doesn’t really matter. We’re out.” 

[packagingworldinsights]

Domino Presents New Monochrome Inkjet Printer at Labelexpo Southeast Asia 2025

Domino Printing Sciences (Domino) is pleased to announce the APAC launch of its new monochrome inkjet printer, the K300, at Labelexpo Southeast Asia. Building on the success of Domino’s K600i print bar, the K300 has been developed as a compact, flexible solution for converters looking to add variable data printing capabilities to analogue printing lines.

The K300 monochrome inkjet printer will be on display at the Nilpeter stand, booth F32, at Labelexpo Southeast Asia in Bangkok, Thailand from 8th–10th May 2025. The printer will form part of a Nilpeter FA-Line 17” hybrid label printing solution, providing consistent inline overprint of serialised 2D codes. A machine vision inspection system by Domino Company Lake Image Systems will validate each code to ensure reliable scanning by retailers and consumers whilst confirming unique code serialisation.

“The industry move to 2D codes at the point of sale has led to an increase in demand for variable data printing, with many brands looking to incorporate complex 2D codes, such as QR codes powered by GS1, into their packaging and label designs,” explains Alex Mountis, Senior Product Manager at Domino. “Packaging and label converters need a versatile, reliable, and compact digital printing solution to respond to these evolving market demands. We have developed the K300 with these variable data and 2D code printing opportunities in mind.”

The K300 monochrome inkjet printer can be incorporated into analogue printing lines to customise printed labels with variable data, such as best before dates, batch codes, serialised numbers, and 2D codes. The compact size of the 600dpi high-resolution printhead – 2.1″ / 54mm – offers enhanced flexibility with regards to positioning on the line, including the opportunity to combine two print stations across the web width to enable printing of two independent codes.

Operating at high speeds up to 250m / 820′ per minute, the K300 monochrome inkjet printer has been designed to match flexographic printing speeds. This means there is no need to slow down the line when adding variable data. Domino’s industry-leading ink delivery technology, including automatic ink recirculation and degassing, helps to ensure consistent performance and excellent reliability, while reducing downtime due to maintenance. The printer has been designed to be easy to use, with intuitive setup and operation via Domino’s smart user interface.

“The K300 will open up new opportunities for converters. They can support their brand customers with variable data 2D codes, enabling supply chain traceability, anti-counterfeiting, and consumer engagement campaigns,” adds Mountis. “The versatile printer can also print variable data onto labels, cartons, and flatpack packaging as part of an inline or near-line late-stage customisation process in a manufacturing facility, lowering inventory costs and reducing waste.”

Code verification is an integral part of any effective variable data printing process. A downstream machine vision inspection system, such as the Lake Image Systems’ model showcased alongside the K300, enables converters and brands who add 2D codes and serialisation to labels and packaging to validate each printed code.

Mark Herrtage, Asia Business Development Director, Domino, concludes: “We are committed to helping our customers stay ahead in a competitive market, and are continuously working to develop new products that will help them achieve their business objectives. Collaborating with Lake Image Systems enables us to deliver innovative, complete variable data printing and code verification solutions to meet converters’ needs. We are delighted to be able to showcase an example of this collaboration, featuring the .”

To find more information about the K300 monochrome printer please visit: https://dmnoprnt.com/38tcze3r

[fishrpg]

2024-09-24: Episode 24 (In The Spider’s Web)

Original airdate December 9, 1992

Episode Synopsis

One of the factories in town, Fresno Industrial Robotic Enterprises, announces a breakthrough in their industrial processing and Dr. Beeker wants to make sure that the new waste leaving the factory is not threatening any downstream wetland ecosystems. The gang helps Dr. Beeker perform tests for environmental quality when they stumble upon a collection of suitcase-sized robots that are currently inactive, are shaped like spiders, and are badly damaged. The damaged robots are leaking chemicals into the water and Dr. Beeker removes them from the water to apply a makeshift barrier to stop it from leaking further, but then the robots suddenly activate!

Each of the spider bots begins building something big, trapping the gang inside and transforming the wetland area into another spiderbot-making factory in only a few minutes. Although the spiderbots are not directly harmful and do not attack, they consume all nearby matter to replicate themselves (posing a problem to the party, who happen to be made of matter). However, the spiderbots will actively try to seal tunnels to trap things that the bots perceive to be threats.

Using their wits, the gang must survive long enough to stop the spiderbots, but the deck is stacked against them! The original spiderbot that started this situation exerts control over all the others, and it will continue to instruct the other bots until enough exist that 8 can be diverted from replication to repair the original spiderbot’s damaged hull. During this repair (which takes about an hour), all the spiderbots except the ones performing the repairs are rendered inactive. This is the best time to attack the controlling spiderbot, because once it gets repaired, the spiderbots will begin trying to spread beyond the factory.

Episode Sponsor: Snow Cone Smasher

Snow cones have never been very exciting to make… Until now! Just put ice cubes between the Snow Cone Smasher’s two ice grating plates and smack it with the included rubber mallet to create perfect shaved ice every time! Despite the marketing copy, the Snow Cone Smasher was not very good at producing shaved ice, the ice grating plates were quite sharp and resulted in many injuries, and it was just plain loud to use because of all the banging. Snow cone season only lasted a single Christmas season before the market ended up trying to liquidate unsold inventory.

Notable Episode Feature: Spiderbot (Item)

All of the spiderbots are identical in size and shape, but the coloration on the body indicates what type of task it is programmed to do. Only the original spiderbot (the one that was leaking chemicals) doesn’t change color; it is the color of bare metal while damaged, and red when repaired. The majority of spiderbots will spend time alternating between purple and green.

Purple spiderbots build walls and tunnels

Green spiderbots consume things to accumulate matter for building

Blue spiderbots store electrical energy and act as batteries

Orange spiderbots synthesize parts to repair other spiderbots

Yellow spiderbots are scouts that patrol the area looking for threats

Red spiderbots control up to 127 other bots, and communicate with other red spiderbots to determine how to allocate resources.

White spiderbots are awaiting orders

Regardless of color, each spiderbot possesses the ability to walk on walls and ceilings, and its mandibles contain a built-in arc welder. The robots were failed prototypes created by Fresno Industrial Robotics Enterprises, and the versions that are in use at the factory now do not have this self-replication problem.

[datageeksociety]

Transfer Learning in NLP: Impact of BERT, GPT-3, and T5 on NLP Tasks

Transfer learning has revolutionized the field of Natural Language Processing (NLP) by allowing models to leverage pre-trained knowledge on large datasets for various downstream tasks. Among the most impactful models in this domain are BERT, GPT-3, and T5. Let's explore these models and their significance in NLP.

1. BERT (Bidirectional Encoder Representations from Transformers)

Overview:

Developed by Google, BERT was introduced in 2018 and marked a significant leap in NLP by using bidirectional training of Transformer models.

Unlike previous models that processed text in a unidirectional manner, BERT looks at both left and right context in all layers, providing a deeper understanding of the language.

Key Features:

Bidirectional Contextual Understanding: BERT’s bidirectional approach allows it to understand the context of a word based on both preceding and following words.

Pre-training Tasks: BERT uses two pre-training tasks – Masked Language Modeling (MLM) and Next Sentence Prediction (NSP). MLM involves predicting masked words in a sentence, while NSP involves predicting if two sentences follow each other in the text.

Impact on NLP Tasks:

Text Classification: BERT's contextual understanding improves the performance of text classification tasks like sentiment analysis and spam detection.

Named Entity Recognition (NER): BERT enhances NER tasks by accurately identifying entities in the text due to its deep understanding of the context.

Question Answering: BERT has set new benchmarks in QA tasks, as it can effectively comprehend and answer questions based on given contexts.

2. GPT-3 (Generative Pre-trained Transformer 3)

Overview:

Developed by OpenAI, GPT-3 is one of the largest language models ever created, with 175 billion parameters.

It follows a unidirectional (left-to-right) autoregressive approach, generating text based on the preceding words.

Key Features:

Scale and Size: GPT-3’s massive size allows it to generate highly coherent and contextually relevant text, making it suitable for a wide range of applications.

Few-Shot Learning: GPT-3 can perform tasks with minimal examples, reducing the need for large labeled datasets for fine-tuning.

Impact on NLP Tasks:

Text Generation: GPT-3 excels at generating human-like text, making it useful for creative writing, chatbots, and content creation.

Translation: While not specifically trained for translation, GPT-3 can perform reasonably well in translating text between languages due to its extensive pre-training.

Code Generation: GPT-3 can generate code snippets and assist in programming tasks, demonstrating its versatility beyond traditional NLP tasks.

3. T5 (Text-to-Text Transfer Transformer)

Overview:

Developed by Google, T5 frames all NLP tasks as a text-to-text problem, where both input and output are text strings.

This unified approach allows T5 to handle a wide variety of tasks with a single model architecture.

Key Features:

Text-to-Text Framework: By converting tasks like translation, summarization, and question answering into a text-to-text format, T5 simplifies the process of applying the model to different tasks.

Pre-training on Diverse Datasets: T5 is pre-trained on the C4 dataset (Colossal Clean Crawled Corpus), which provides a rich and diverse training set.

Impact on NLP Tasks:

Summarization: T5 achieves state-of-the-art results in text summarization by effectively condensing long documents into concise summaries.

Translation: T5 performs competitively in translation tasks by leveraging its text-to-text framework to handle multiple language pairs.

Question Answering and More: T5's versatility allows it to excel in various tasks, including QA, sentiment analysis, and more, by simply changing the text inputs and outputs.

Conclusion

BERT, GPT-3, and T5 have significantly advanced the field of NLP through their innovative architectures and pre-training techniques. These models have set new benchmarks across various NLP tasks, demonstrating the power and versatility of transfer learning. By leveraging large-scale pre-training, they enable efficient fine-tuning on specific tasks, reducing the need for extensive labeled datasets and accelerating the development of NLP applications.

These models have not only improved the performance of existing tasks but have also opened up new possibilities in areas like creative text generation, few-shot learning, and unified task frameworks, paving the way for future advancements in NLP.

[visions--of--collisions]

For @its-just-a-glitch who asked for 4(T):

There's one spot left on the requests post if anyone wants it :)

EXCERPT: Argey Bargey (Spiderverse, Hobie/Miles, Rated T, Post-BtSV)

The portal spits him out on the waterside, is the only thing Miles can tell for sure, at first. Earth 138 is always a shock to the senses in the first couple minutes, from the colors to the contrasts to the torn paper edges you could see if you focused on your peripheral vision long enough. Pav and he had freaked each other out once by concentrating hard enough on a magazine spread to make out the Lorem ipsum dolor sit amet hidden inside the body of the printed text itself.

The smell and the sound of the water is enough to reassure Miles he’s where he should be, anyway, despite the mist like flecks of paint hanging in the air. He shivers a little in the damp chill and pulls up the messenger on his phone: Hey man, I’m here. Where u at?

Omw mate, stay put, comes the response.

Miles huffs and fires back a kaomoji. Staying put's a solid option, he figures, considering he has basically no idea where he is and can barely see six feet in front of him, even with enhanced senses. He's pretty sure the faint gray gradient up above is the sky, by process of elimination. There's some  over-saturated weeds growing through the paving under his feet, and the jagged outline of tall grasses growing along the edge of it. The rippling breadth of the canal is clearish in front of him, but when Miles peers upstream or downstream it recedes into a vague, dark road behind the fog.

Are we really in New London, here? He’s turning a slow circle, squinting in all directions to try to make out any sign of a high-rise or a smoke stack, when his Spidey Sense comes skittering up the knobs of his spine to set his scalp tingling. The hum of what might be an engine follows, steadily growing closer. Miles pushes back his mask and squints in the pertinent direction. He steps closer to the water’s edge, just as a shape becomes visible through the mist, gaining definition as it approaches.

He blinks and the silhouette becomes the nose of a boat. Miles stares as it drifts toward and then past him. There’s spraypaint and … paint-paint in arcing splotches all over the - hull, Miles wants to call it? Flyers are littered across the walls (and roof) of what he figures is the cabin. Someone’s drawn dumb faces in the holes made by the lifebuoys mounted on the sides of the craft. He’s so occupied with trying to take in the whole … thing, that it takes Miles a minute to notice he’s being watched.

Hobie is at the rear of the craft when Miles finally clocks him, one hand on the tiller, the other stuffed into his back pocket. He's wearing a frayed white battle jacket, and the neutral expression of a guy who has no idea he's the coolest thing his friend has seen in the last week.

And it’s been a Week.

He nods, once, eyeing Miles sideways. 'Alright?'

‘Alright,’ Miles parrots, gawking. ‘Sure.’ He shakes his head and jogs forward to keep pace as the craft trundles onward. 'Wow. Shouldn't you have one of those cable knit sweaters and the little, you know,' Miles mimes the shape of a brim, 'Captain's hat on?'

Hobie only looks at him, seemingly impervious to the baiting. He shrugs, finally. 'Yeah, but I flogged them, innit?'

Miles makes a face, and Hobie cracks a smile, at last. 'D'you need permission to board or something?’ he asks, curiously. ‘Or were you plannin' to walk?'

Miles raises his palms. 'I dunno, man, you're the boat guy! Don't you gotta put down the anchor, or blow your horn or something?'

The neutral look returns to Hobie’s face in response, accented with a judgemental tilt. Miles keeps his smile fixed and his pace steady, even as the barge drifts ahead of him. Hobie turns his head slowly, owl-like, to keep him so pinned.

Miles is just starting to worry about losing him to the fog when Hobie reaches for something, still staring, and he jumps when a hollow noise, like a foghorn sized down, bounces off the water and the paving stones under his feet. Something up ahead makes a high, honking complaint and takes off in a flurry of wings; Miles chuffs at the sight of its pale belly and webbed feet passing overhead, barely visible through the mist, and bends his knees to hop aboard.

[TBC]

[female-malice]

@ British Columbians!!!

The Ministry of Forests is accepting comments on the Kootenay Lake Timber Supply Area Review until July 4th. Click here to write your comments to:

Ian Wiles, Stewardship Officer, Selkirk Resource District (Ian.Wiles@gov.bc.ca)

Shane Berg, Chief Forester (Shane.Berg@gov.bc.ca)

Honourable Bruce Ralston, Minister of Forests (FOR.Minister@gov.bc.ca)

Forest Analysis and Inventory Branch, Victoria (Forests.ForestAnalysisBranchOffice@gov.bc.ca)

Add your location after your name, so they know that you’re local to the area.

Key issues to consider to write your comments

The most important message is that cut levels must be radically reduced to reflect the on-the-ground reality of our forests, the priorities of local communities and Indigenous Nations, and the health of our ecosystems.

Old Growth

The province must stop using an oldest-first harvest strategy in the Timber Supply Review Process. We should be protecting our old growth, not targeting these stands for logging. In many parts of the Kootenay Lake TSA, less than 10% of the old growth forests are still standing. It’s time to stop logging old growth and to calculate the Annual Allowable Cut with the assumption that no more old growth will be cut.

The Annual Allowable Cut is based on the Timber Harvesting Land Base (the area of forest that is theoretically available for logging over time). Even though BC has deferred logging on 62,055 hectares of old growth forest in the Kootenay Lake Timber Supply Area, they still are including many of these areas in the Timber Harvesting Land Base, meaning other areas suffer even more logging because the calculations are based on forests that aren’t really available for logging. The chief forester has to adjust the AAC to account for the areas set aside for old growth.

Seventy-eight percent of designated Old Growth Management Areas (another designation meant to protect old growth) over two hectares in size in the Kootenay Lake TSR are actually in sub-alpine areas that cannot be logged anyways. Old Growth Management Areas should be designated where old growth can actually be protected from logging. Pretending to protect something that was never threatened by logging just inflates the numbers.

Protect Our Water

The current and projected AAC relies on harvesting community watersheds. Thirty percent of the Timber Harvesting Land Base is in community watersheds. We need a precautionary approach that excludes community watersheds from the Timber Harvesting Land Base. We have to protect our drinking water. Industrial logging in watersheds sends sediment downstream into our drinking water, reducing water quality. Logging large swaths of mature forest in watersheds also makes floods in our communities more likely. Recent literature suggests that after 30% of a watershed is logged, what used to be a once-in-a-century flood comes around every 15 years.

Climate Change Realism

We know that climate change will result in more fires and flooding, increased regeneration delays, more extreme weather, and more beetle outbreaks. That means less wood available. The Ministry says that we can’t forecast the exact quantitative effects of climate change, so they pretend those effects don’t exist. The Ministry must reduce cut levels to a precautionary level to account for climate change.

Look Forwards, Not Backwards In The TSR

The TSR process has to look forward and integrate reasonable assumptions about our future and on-the-ground realities into models used to calculate the Annual Allowable Cut. That means not only that old growth deferrals and community watersheds need to be taken out of the Timber Harvesting Land Base, but also that government commitments to shifting away from clearcut logging, improving forestry practices on the ground and ecosystem needs all must be incorporated into the model.

Thanks for speaking up!

[confectionerymachines2025]

High-Performance Lollipop Machine Solutions by Latini-Hohberger Dhimantec

Latini-Hohberger Dhimantec stands at the forefront of the confectionery machinery industry, delivering exceptional and innovative equipment that powers modern candy production worldwide. Among their leading solutions, the Lollipop Machine, Lollipop Packing Machine, and Lollipop Wrapping Machine have become indispensable tools for manufacturers aiming for precision, hygiene, and speed in the production line. Designed with cutting-edge technology and decades of engineering expertise, these machines offer complete automation in shaping, cooling, packaging, and wrapping of lollipops—ensuring consistent quality and high output with minimal human intervention.

The Lollipop Machine by Latini-Hohberger Dhimantec is engineered for excellence, catering to a wide variety of lollipop shapes and sizes. Whether it's flat, round, oval, or 3D forms, the machine accommodates different molds and configurations, making it a versatile solution for candy producers. Equipped with high-speed forming capabilities, the Lollipop Machine guarantees precision molding, controlled weight distribution, and seamless integration with downstream packing and wrapping systems. The robust stainless steel build and easy-to-clean surfaces ensure hygienic processing, while the smart control systems make operation simple and efficient for operators of all skill levels.

A standout feature of Latini-Hohberger Dhimantec’s machinery is its seamless transition from formation to packaging. The Lollipop Packing Machine complements the production line by automating the bagging, flow wrapping, or stick insertion processes depending on the chosen packaging style. This machine operates at high speeds without compromising on the quality of seal integrity or visual presentation. Perfect for both small-scale boutique operations and large-scale mass production, the Lollipop Packing Machine ensures that every product is handled delicately yet quickly, maintaining product integrity from start to finish. Advanced sensors and PLC-based control systems allow for real-time monitoring and adjustments, reducing downtime and optimizing productivity.

When it comes to aesthetic appeal and hygienic sealing, the Lollipop Wrapping Machine is the ultimate solution. Available in both single twist and bunch wrap configurations, it provides reliable, high-speed wrapping that not only preserves freshness but also enhances visual appeal—making it ideal for both retail and export markets. Designed for ease of operation, minimal maintenance, and maximum uptime, the Lollipop Wrapping Machine incorporates servo-driven systems that ensure each wrap is tight, centered, and tamper-evident. The compact layout of this machine also makes it space-efficient, and its modular design allows manufacturers to upgrade or integrate with existing systems easily.

These three machines—Lollipop Machine, Lollipop Packing Machine, and Lollipop Wrapping Machine—form a complete production-to-packaging ecosystem. Manufacturers no longer need to rely on multiple vendors or worry about inter-system compatibility. Latini-Hohberger Dhimantec’s integrated solutions are built to function in harmony, reducing errors, increasing production rates, and ensuring that every lollipop meets the brand’s standards of quality, hygiene, and presentation.

Another hallmark of Latini-Hohberger Dhimantec’s machinery is its focus on safety and compliance. All equipment adheres to international food safety standards, including FDA and CE certifications. The company also prioritizes energy efficiency, reducing environmental impact while keeping operating costs low. With safety shields, emergency stop buttons, and real-time alert systems, the machines not only protect the product but also ensure the well-being of machine operators.

Maintenance and servicing are made easy with user-friendly interfaces and remote diagnostics. Latini-Hohberger Dhimantec provides extensive support post-installation, including training, spare parts availability, and 24/7 technical assistance. Their global network ensures fast service response times, which helps manufacturers maintain continuous production cycles with minimal interruptions. Additionally, clients can request customization features or retrofitting solutions to adapt older machinery to newer, more energy-efficient formats.

The global confectionery market is highly competitive, and product differentiation starts with quality and consistency. Latini-Hohberger Dhimantec understands these challenges and builds its machinery to empower candy manufacturers with the tools they need to lead the market. Whether a company is looking to scale up operations or introduce a new line of products, the Lollipop Machine, Lollipop Packing Machine, and Lollipop Wrapping Machine provide the reliability, performance, and flexibility needed to stay ahead in the industry.

Moreover, the machines are designed with scalability in mind. As production demands increase, manufacturers can add new modules or synchronize with other processing units without having to overhaul their entire setup. The modular approach also supports innovation in candy design, enabling producers to experiment with new shapes, flavors, and packaging styles. From product development to final packaging, Latini-Hohberger Dhimantec machinery allows for experimentation without sacrificing efficiency.

In today’s consumer-driven environment, appearance, packaging, and shelf life are as crucial as taste. The high-quality output from the Lollipop Machine ensures uniform shapes and smooth textures. The Lollipop Packing Machine protects the product from moisture and external contaminants, while the Lollipop Wrapping Machine adds the final visual flourish that attracts buyers at point-of-sale. Together, they create a production pipeline that supports branding, logistics, and customer satisfaction.

Clients across the globe—from North America to Southeast Asia—trust Latini-Hohberger Dhimantec for their reliability, innovation, and engineering precision. Their commitment to technological advancement, customer service, and long-term value makes them the preferred partner for confectionery businesses aiming for excellence in manufacturing and presentation.

To conclude, Latini-Hohberger Dhimantec offers a comprehensive suite of confectionery solutions that address the complete lifecycle of lollipop production. Their Lollipop Machine, Lollipop Packing Machine, and Lollipop Wrapping Machine are more than just tools—they are strategic investments that enhance quality, boost production, reduce waste, and future-proof confectionery businesses for years to come. By choosing these advanced machines, manufacturers align themselves with a legacy of engineering brilliance and a vision for sustainable, high-quality candy production.

[best-testing-lab-saudi]

How REACH Testing Labs in Ajman Help Small Businesses Achieve Chemical Compliance? | +971 554747210

In today’s highly regulated global market, compliance with chemical safety standards is no longer optional — it’s essential, especially for small businesses aiming to expand and compete internationally. For small manufacturers, importers, and exporters in Ajman, understanding and adhering to the REACH regulation (Registration, Evaluation, Authorisation, and Restriction of Chemicals) can be a complex and daunting task. This is where specialized REACH Testing Lab in Ajman play a critical role by providing the testing, guidance, and certification needed for chemical compliance.

This blog explores how REACH Testing Labs in Ajman empower small businesses to meet stringent chemical safety requirements, reduce regulatory risks, and access lucrative markets such as the European Union.

Understanding REACH Regulation and Its Relevance to Small Businesses

REACH is a comprehensive European Union regulation designed to protect human health and the environment from the risks posed by chemicals. It requires businesses to identify the chemical substances in their products, assess potential hazards, and ensure safe use. For small businesses in Ajman, which operate in sectors like textiles, plastics, electronics, cosmetics, and more, complying with REACH is crucial for exporting goods to Europe.

Non-compliance can lead to denied market entry, expensive recalls, and legal penalties — consequences that can be particularly damaging for small businesses with limited resources. Hence, access to reliable and affordable REACH Testing Labs is a game-changer for Ajman’s SMEs.

Challenges Faced by Small Businesses in Achieving REACH Compliance

Small businesses often face unique challenges when it comes to chemical compliance:

Limited technical expertise: Many small businesses lack in-house experts to navigate the complexities of chemical regulations.

Budget constraints: High testing costs can be prohibitive.

Resource limitations: Small teams may struggle to keep up with constantly evolving REACH requirements.

Complex supply chains: Ensuring all suppliers comply with REACH is difficult without proper testing support.

These hurdles can delay product launches and limit market access — highlighting the importance of professional testing labs.

How REACH Testing Labs in Ajman Support Small Businesses

1. Affordable and Tailored Testing Solutions

REACH Testing Labs in Ajman understand the budgetary constraints of small businesses and offer flexible, cost-effective testing packages. These labs tailor their services to the size and nature of the business, helping SMEs test only the necessary materials and substances relevant to their products. This approach prevents overspending while ensuring compliance.

2. Comprehensive Chemical Analysis

Using advanced instrumentation such as ICP-MS (Inductively Coupled Plasma Mass Spectrometry) and GC-MS (Gas Chromatography-Mass Spectrometry), Ajman-based labs accurately detect hazardous substances including heavy metals, phthalates, and other restricted chemicals. Accurate testing identifies potential compliance issues early, preventing costly downstream problems.

3. SVHC Screening and Risk Assessment

Substances of Very High Concern (SVHC) pose significant regulatory risks under REACH. Testing labs help small businesses screen products for SVHCs listed by the European Chemicals Agency (ECHA), enabling early identification and risk mitigation. Labs also provide expert advice on managing or substituting hazardous substances, guiding safer product development.

4. Expert Consultancy and Regulatory Guidance

REACH compliance involves more than testing — it requires an understanding of complex legislation. Ajman REACH Testing Labs offer consultancy services to educate small businesses on their legal responsibilities, documentation requirements, and regulatory updates. This guidance simplifies the compliance process and reduces the likelihood of errors.

5. Supply Chain Verification

Many small businesses rely on multiple suppliers for raw materials and components. Testing labs assist by verifying that suppliers’ products meet REACH standards. This comprehensive approach helps SMEs maintain compliance throughout their supply chains and avoid liability for non-compliant inputs.

6. ISO Accreditation and Quality Assurance

Leading REACH Testing Labs in Ajman operate under ISO/IEC 17025 accreditation, guaranteeing the accuracy and reliability of test results. For small businesses, partnering with an accredited lab builds credibility with buyers and regulatory authorities, ensuring that compliance certifications are internationally recognized.

Benefits of Using REACH Testing Labs for Small Businesses in Ajman

Access to Global Markets

Compliance with REACH is often a prerequisite for exporting to the European Union. Testing labs enable small businesses to meet these requirements efficiently, unlocking access to one of the world’s largest and most lucrative consumer markets.

Avoidance of Legal Risks and Financial Penalties

Non-compliance can result in fines, product recalls, and bans. Early detection of chemical risks through professional testing protects small businesses from such costly consequences.

Enhanced Product Safety and Consumer Trust

Testing confirms that products are safe and free from harmful substances, boosting consumer confidence and enhancing brand reputation — critical factors for small businesses competing on quality.

Streamlined Compliance Process

By outsourcing testing and consultancy to expert labs, small businesses can focus on core operations while ensuring regulatory obligations are met seamlessly.

How to Choose the Right REACH Testing Lab in Ajman for Your Small Business

Choosing the ideal REACH Testing Lab is vital for effective compliance. Small businesses should consider:

Accreditation: Ensure the lab is ISO/IEC 17025 accredited.

Experience: Look for labs familiar with your industry and product types.

Range of Services: Choose labs that offer testing, consultancy, and supply chain verification.

Turnaround Time: Fast, reliable results are important for agile businesses.

Cost-Effectiveness: Find labs offering packages tailored for SMEs.

Customer Support: Responsive communication and expert advice add significant value.

Real-Life Impact: Success Stories from Ajman Small Businesses

Many Ajman SMEs have transformed their export prospects by collaborating with REACH Testing Labs. For instance, a local textile manufacturer identified restricted azo dyes in their products during testing, allowing them to reformulate before shipment — avoiding costly recalls and gaining EU market approval. Similarly, a small electronics firm detected hazardous flame retardants in components, switched suppliers, and ensured their products met REACH standards, winning contracts with European distributors.

Conclusion

For small businesses in Ajman, navigating the intricate REACH regulation can be overwhelming but unavoidable. The expertise and services provided by professional REACH Testing Labs are indispensable in this journey. From cost-effective chemical testing and SVHC screening to consultancy and supply chain verification, these labs offer comprehensive support tailored to the unique needs of SMEs.

By partnering with a reliable, ISO-accredited REACH Testing Lab in Ajman, small businesses can confidently achieve chemical compliance, avoid legal pitfalls, enhance product safety, and expand their global reach — all critical ingredients for sustainable growth in today’s competitive markets.

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The Role of Conical Strainers in Protecting Pumps and Valves

Protecting pumps and valves from debris during system startup ensures reliable operation and avoids costly downtime. New or modified pipelines often carry leftover construction materials—like rust, welding slag, and scale—that can seriously damage sensitive components. This is where conical strainers play a critical role.

What Are Conical Strainers and Why Are They Important?

Conical strainers (temporary cone strainers )are cone-shaped mesh or perforated metal filters placed between pipe flanges. They're designed for short-term use during pipeline systems' commissioning or startup phase.

When fluid flows through a newly installed system, it can carry construction debris that may damage pumps, control valves, and meters. Conical strainers capture this debris early on, offering essential protection when the system is most vulnerable.

Why Startup Debris Is Dangerous

New pipeline systems often contain:

Welding slag

Rust particles

Pipe scale

Jointing compound

These materials can lead to:

Abrasion and erosion of the pump and valve components

Clogging of narrow passages and filter elements

Seizing of moving parts due to large debris

Reduced performance and internal leakage

How Conical Strainers Work

The effectiveness of conical strainers lies in their design. Inserted between two pipe flanges, their cone shape offers a large surface area for filtering. As the fluid passes through, solid contaminants get trapped inside or outside the cone—depending on the orientation.

This setup ensures:

High filtration efficiency

Low pressure drop

Easy debris collection and removal

Benefits of Using Conical Strainers

Using a conical strainer during startup provides several advantages:

 Protects expensive components from early failure

 Extends equipment lifespan by preventing wear

 Reduces maintenance costs and emergency interventions

 Prevents unplanned downtime

 Improves overall system reliability

Material Options:

Stainless Steel 304 / 316 (corrosion resistance)

Carbon Steel

Monel and other specialty alloys

Key Specs to Consider:

Mesh/perforation size (determines what particles are captured)

Open area ratio (impacts flow capacity)

Installation Best Practices

To maximize performance:

Orientation: Install the cone upstream or downstream based on system needs.

Sizing: Match pipe diameter, flange rating, and bolt circle.

Sealing: Use appropriate gaskets to ensure leak-free operation.

Temporary Use and Maintenance

Most conical strainers are designed for short-term use. Once the system has been flushed and debris removed, the strainer should be taken out to prevent pressure drop and clogging.

To remove:

Isolate the section

Depressurise the line

Unbolt the flanges

Remove the strainer carefully.

Conical vs. Permanent Strainers

Use Conical Strainers for temporary protection during startup.

Use Permanent Strainers (like basket or Y-type strainers) for ongoing filtration needs.

Industries That Use Conical Strainers

Conical strainers are widely used in industries where clean fluid flow is essential from the start:

 Oil & Gas

 Chemical Processing

 Power Generation

 Marine

Water Treatment

 Food & Beverage / Pharmaceutical

 Pulp & Paper

Final Thoughts: Start Clean, Stay Efficient

A smooth startup sets the foundation for reliable operations. Conical strainers are a cost-effective, temporary filtration solution that protects your pumps, valves, and instrumentation from damaging debris. They help avoid unexpected downtime and reduce long-term maintenance costs.

If you're commissioning a new system, don’t overlook this small but powerful piece of equipment. It’s been the smart way to protect your bigger investments from day one.

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