#giles from 1br

[goryhorroor]

the best/questionable little (and one big) kitties in horror cinema

[peacehopeandrats]

Hello again from Santa! I am so sorry it's taken me a while to leave you a message. I had some sad events here. :( I am working on your gift. I hope you are well! I totally agree with your most recent reblog about Rumple, btw. Seriously! Are you watching any other shows at the moment that you would recommend?

Unfortunately this has been the year of sad events and I am very sorry to hear of yours. Hopefully this answer finds you in a better place than you had been in at the start of your question.

I watch actors more than shows. My father quite literally raised me on Star Trek and taught me to look at television with the eye of someone who could enjoy both the art of storytelling and the story that was actually being told. The result was that I will watch any Star Trek and then watch any actor/actress who catches my eye. This was how I came to Once, by the way, following Oded (and Robert Carlyle, but therein lies a story too long for your answer) to this show about fairy tales that I was positive I would hate. Now that our Jafar has crossed the threshold into Star Trek I am simply overjoyed. I think I’ve been celebrating that journey the most lately.

Outside of that, if we are talking about people with current projects, Freddie Highmore’s work in the Good Doctor is simply brilliant. I came to him through Vera Farmiga, another actress I highly recommend that people follow. They were the stars of A&E’s Bates Motel, which you’ll forgive me for announcing if you already know, since I must guess if this is familiar or not to an anonymous asker. It was Oded who brought me to Vera, so I guess that takes me full circle on that front.

Past shows that I’d recommend would be Hell on Wheels (if you are a fan of westerns) and Anson Mount, Chris Heyerdahl, and Common, who work in it. Christopher Heyerdahl can literally throw an entire performance into the way he moves his toes and my following his work took me to this amazing tale of exploration and revenge. Anson is also phenomenal at what he does. His podcast (The Well) is a must listen for anyone who enjoys the arts in an intellectual sort of way. 

Another show from the past is Sense 8, one of the few pieces of small screen drama that I tried for the pure joy of the story and not because I had one actor or the other in mind. I was not at all disappointed in that decision. 

There is also Sleepy Hollow, which was filmed semi-locally to me, so I have an affection for it naturally, but the writing in the first seasons is simply brilliant, as are most of the cast. Thanks to this show I will forever complain about autocorrect by typing “poor cellophane conception” and imagine my phone sliding across the table whenever it tells me to swipe to unlock it.

Of course, if we share similar tastes, you probably have seen some of the above, so let’s see what I can get you that might not be something I’ve shared before...

My wife and I recently started watching Shameless, not because of the cast but because she is someone who can actually just watch television as television and not for a particular reason. It is a harsh reality of a family living with so much difficulty, but a story I am finding that I actually want to be told. We have a lot of catching up to do, but I don’t see myself pulling away until the very end.

Colin  O'Donoghue ‘s work has grown on me since Once Upon A Crime (my name for Season 7) and I’ve been catching up on The Right Stuff, which I’d paused due to life and all the little things that kept me from having any actual free time to speak of. I think I’ve seen Giles’s 1BR three times now and just recently devoured all of Sebastian Stan’s show Kings.

I think all of this is much more than you were after, of course. lol Me and my ramblings.

[thegeekcurmudgeon]

The Other Worlds 2019 preview Day 3

Art by Lauren Kitching

Returning for a sixth exciting year, Other Worlds, one of the premier SciFi Film Festivals in the US, features some of the best and unheralded genre films. Beginning on Thursday December 5 at Austin’s Galaxy Highland 10, the four day event includes over 20 feature films, a slew of shorts, a screenwriting workshop, and the Mary Shelley Award. This year also features the return of Under Worlds, which brings the best of indie to Austin.

Not terribly surprising to anyone who regularly follows my writings, I’ll be there.

Here’s what to expect at Other Worlds 2019.

Saturday, December 6

11:30AM SciFi Shorts 1: Love in the Time of Robots

11:30AM Dementer (Texas PREMIERE)

Chad Crawford Kinkle | USA | 80 min

Writer: Chad Crawford Kinkle Cast: Larry Fessenden, Katie Groshong, Stephanie Kinkle, Scott Hodges

Katie begins to put her life back together after escaping a backwoods cult by taking a job in a home for special needs adults. Then the dark messages of her past tell her one of the sick patients needs more than just medicine. Dementer is an art house horror passion project that came to life when director, Chad Crawford Kinkle wanted to make a film with his special needs sister. Shot in an almost documentary style, the film embraces and properly represents the developmentally disabled, both in the script and in the actual casting, while still being both thrilling and disturbing.

11:45AM I Am Human (Texas Premiere)

Taryn Southern, Elena Gaby | USA | 90 min

I AM HUMAN explores the co-evolution of humans and technology, focusing on a small group of people with different ailments that choose to use robotic implants to cure themselves. Diving deep into the current technology and where science could take us in the future, I AM HUMAN fills its frames with heart-warming stories of real people and their process of deciding to accept technology as a part of their bodies.

1:50PM 1BR (TEXAS PREMIERE)

David Marmor | USA | 90 min

Writer: David Marmor Cast: Nicole Brydon Bloom, Taylor Nichols, Giles Matthey 

After leaving behind a painful past to follow her dreams, Sarah scores the perfect Hollywood apartment. But something is not right. Unable to sleep, tormented by strange noises and threatening notes, her new life quickly starts to unravel. By the time she learns the horrifying truth, it’s too late. Caught in a waking nightmare, Sarah must find the strength to hold onto her crumbling sanity…or be trapped forever in an existential hell. 

2PM SciFi Shorts 2: Crossing Over to the Future

2:15PM LIVE FROM OTHER WORLDS FILM FEST – IT’S “SCIENCE VS FICTION”

Scott Weinberg is a veteran film critic. Steven DeGennaro is a doctor of astrophysics. Every week they compare and contrast two noteworthy SciFi films on their popular podcast “Science vs Fiction,” where they discuss the artistic quality of the films, whether they get the science right, and whether or not that even matters. Past pairings have included ARMAGEDDON vs DEEP IMPACT, ALIENS vs STARSHIP TROOPERS, and JASON X vs LEPRECHAUN IN SPACE IN SPACE.

Other Worlds, they will open the massive can of worms that is cinematic time travel when they turn their talents on the 1979 classic (and Opening Night Film!) TIME AFTER TIME.

4:20PM The SciFi Lecture: The Old Dark Trope

“It was a dark and stormy night.” The couple’s car breaks down, blows a tire, crashes into a tree and runs out of gas. Yes, all at the same time. An ominous Victorian house at the top of the hill is the only refuge for miles and miles. They have nowhere to go and must seek refuge in THE OLD DARK HOUSE.

This year at Other Worlds, we are exploring the trope of the Old Dark House, how it originated, other tropes and stories that appear in within the Old Dark House, and how the trope has evolved and continues to be used today. Join Other Worlds Programmer and Screenwriting Director Eric Harrelson for a discussion and curated clip show curated by Other Worlds newest Programmer Wyatt Walker. Find out why old tropes never die, they just get subverted.

4:25PM Long Shorts: Lingering Visions

4:35PM Dead Dicks (US PREMIERE)

Chris Bavota, Lee Paula Springer | Canada | 83 min

Writers: Chris Bavota, Lee Paula Springer Cast: Heston Horwin, Jillian Harris, Matt Keye

When a young nursing student named Becca receives a series of panicked messages from her older brother Richie, she rushes over to check on him. Following a seemingly successful suicide attempt, Richie, who suffers from mental illness, discovers what appears to be his own dead body. When Becca gets to his apartment, they find more dead versions of Richie as well as a strange hole in his bedroom wall. Together, they must figure why his suicide just won’t keep.

4:20 UW Shorts: Dark Nights & Dark Thoughts

7:20PM Afterlife

Willem Bosch | The Netherlands | 93 min

Writer: Willem Bosch Cast: Sanaa Giwa, Romana Vrede, Gijs Scholten van Aschat, Jan-Paul Buijs 

After her mother’s passing, teenage Sam takes up most of the household responsibilities. When she, too, ends up in the afterlife and finds out she can get a do-over, Sam gives life another try with the sole mission of saving her mother. A fantasy science fiction film, Afterlife tugs on the heart strings and deals with the hard realities of life and death.

7:30PM The Ascent (North American Premiere) (screens again Sunday, 2:15PM)

Tom Paton | UK | 100 min

Writer: Tom Paton Cast: Rachel Warren, Simon Meacock, Bentley Kalu

Special ops squad “Hell’s Bastards” are sent to infiltrate a civil war to retrieve intel. The unit soon find themselves trapped on a never-ending stairwell forced to climb or die. To survive, they must revisit their past sins if they ever want to get off. 

9:45PM Doppelganger (Founder’s Choice)

10PM Volition (Texas Premiere)

Tony Dean Smith | USA | 91 min

Writers: Tony Dean Smith, Ryan W. Smith Cast: Adrian Glynn McMorran, Magda Apanowicz, John Cassini

On a rain-soaked night in 1991, two cars collide, leaving all drivers dead on the scene, including the mother of the lone survivor – a child – James Odin. Seven-year-old James foresaw the accident happening two days prior and tried to prevent it, but who’s going to believe a kid who claims to see the future? Twenty-plus years later, James is a product of the failed foster care system, using his ability for petty crime and cheap thrills. But when a pre-sentient vision reveals to him his own imminent murder, James must go on the run and change a fate he knows is fixed.

10:15PM Scare Package (Texas Premiere) Under Worlds Centerpiece Film

USA | 103 min

Directors: Emily Hagins, Baron Vaughn, Noah Segan, Chris McInroy, Anthony Cousins, Hillary & Courtney Andujar, Aaron B. Koontz Cast: Toni Trucks, Joe Bob Briggs, Dustin Rhodes, Chase Williamson, Baron Vaughn, Noah Segan

A meta Horror-comedy anthology film where each segment subverts a different set of Horror tropes, SCARE PACKAGE intertwines its components around the on-boarding of a mysterious new employee at a struggling genre video store: Rad Chad’s Horror Emporium.

This year’s Under Worlds Centerpiece film is very special for our programming team for many reasons. It’s an intelligent, creative look at the Horror genre that is both hilarious and scary. Furthermore, three of the segments were shot here in Austin by local filmmakers, one of whom is an Other Worlds alumni. The producing team for the film does a great job managing the tone of the anthology while still maintaining each director’s vision. It is rare to see an anthology film where connecting material is just as compelling as the individual parts, but the team has done it here.

The Other Worlds 2019 preview Day 3 was originally published on The Geek Curmudgeon

[creepykingdom]

“1BR” Has It’s US Premiere at BeyondFest

By John Duarte

When you move into an apartment building for the first time, Have you had other people in the apartment give you a weird but happy look when you move in? Luckily, I haven’t but if you did,...That is what the character of Sarah (Nicole Brydon Bloom) has to deal with and a whole lot more in the movie “1BR”. We see Sarah who moved to LA to start a new life after for herself and become a costume designer but works as a temp for a law firm to pay the bills, she tries to find an apartment to move into somewhere in the suburbs (Most likely the San Fernando Valley) when she stops by the Asilo Del Mar apartment living to fill an application out. Out of all the candidates who filled out the applications, she’s the one they picked. 

After she moves in along with her cat (By the way, the apartment is a pet-free zone so no one knows she has one.) She gets welcomed by the community in the building starting with Brian (Giles Matthey) who helps her get settled in. She also befriends an older woman named Miss Stanhope (Susan Davis) and finally the head of the apartment building Jerry (Taylor Nichols) & his wife Janice (Naomi Grossman). Sarahs first night there feels a little strange and she thinks someone is inside her place. A mysterious note gets slipped under her door. As she reads it, someone knows she’s hiding her cat in the apartment. The next night, Yeah, you guessed it. Someone throws the cat in the kitchen stove. Don’t you hate when that happens? 

So mysterious figures knock Sarah out (which turns out to be Brian and Jerry) and throw her in the same room she went in during the open house in the first scene in the movie. She gets punished and kind of tortured to the point of forcing her to stand up and they also hammer nails to the palm of her hands to keep her standing up all night. This is all because they want to teach her a lesson in being selfless and Jeff finally explains that the entire apartment complex has all been through this torture and they had to read a book called “The Power of Community”. So basically, it’s kind of a cult. 

So that’s basically the plot of this movie. Does hilarity ensue??? Nope, not at all. The first half of the movie goes pretty quick with the kidnapping of Sarah clocking in at the 25 min mark. Around the hour mark, the pacing drags and it loses my attention because there are characters you don’t really care about and it just takes a while until we get into the climax of the movie. But, once we get there, You quickly wake up from your 10-15 min nap and it kicks into high gear. This is the first feature by writer & director David Marmor. His direction was a little flat but there were a couple of standout performances. Mainly the 3 leads of Sarah, Brain, and Jeff. The other characters didn’t get as much love. But what I did enjoy was the final sequence and kind of a surprise ending which this film would easily fit into an Anthology series like “The Twilight Zone” or “Black Mirror”. 

“1BR” had it’s United States Premiere on September 28, 2019 at BeyondFest in Los Angeles.

[tumimmtxpapers]

T follicular helper cells in human efferent lymph retain lymphoid characteristics.

Related Articles T follicular helper cells in human efferent lymph retain lymphoid characteristics. J Clin Invest. 2019 Jul 02;130: Authors: Vella LA, Buggert M, Manne S, Herati RS, Sayin I, Kuri-Cervantes L, Bukh Brody I, O'Boyle KC, Kaprielian H, Giles JR, Nguyen S, Muselman A, Antel JP, Bar-Or A, Johnson ME, Canaday DH, Naji A, Ganusov VV, Laufer TM, Wells AD, Dori Y, Itkin MG, Betts MR, Wherry EJ Abstract T follicular helper cells (Tfh), a subset of CD4+ T cells, provide requisite help to B cells in the germinal centers (GC) of lymphoid tissue. GC Tfh are identified by high expression of the chemokine receptor CXCR5 and the inhibitory molecule PD-1. Although more accessible, blood contains lower frequencies of CXCR5+ and PD-1+ cells that have been termed circulating Tfh (cTfh). However, it remains unclear whether GC Tfh exit lymphoid tissues and populate this cTfh pool. To examine exiting cells, we assessed the phenotype of Tfh present within the major conduit of efferent lymph from lymphoid tissues into blood, the human thoracic duct. Unlike what was found in blood, we consistently identified a CXCR5-bright PD-1-bright (CXCR5BrPD-1Br) Tfh population in thoracic duct lymph (TDL). These CXCR5BrPD-1Br TDL Tfh shared phenotypic and transcriptional similarities with GC Tfh. Moreover, components of the epigenetic profile of GC Tfh could be detected in CXCR5BrPD-1Br TDL Tfh and the transcriptional imprint of this epigenetic signature was enriched in an activated cTfh subset known to contain vaccine-responding cells. Together with data showing shared TCR sequences between the CXCR5BrPD-1Br TDL Tfh and cTfh, these studies identify a population in TDL as a circulatory intermediate connecting the biology of Tfh in blood to Tfh in lymphoid tissue. PMID: 31264971 [PubMed - in process] http://dlvr.it/R7kR56