#iga nephropathy

[vikingstoner69]

So as some of you may know I have end stage kidney disease and have been working very hard to get on the transplant list. Well this morning I got the call saying I am on the list and at the top so have a bag ready for the call that could happen at any time. So fics may stop for a bit suddenly that's mostly I'm in the hospital with a new kidney.

[doodlesmom]

In The News...

An article in the Toronto Star today… http://www.healthzone.ca/health/article/1008131–ontario-creates-online-donor-registry 2 words:  about time. Check it out and sign up, please. … —- **Update, the website crashed opening day because so many people tried to sign up.  A mark of success. I was one of the 500 people who successfully signed up.  When’s your turn?  They should be up and running…

[dangerdust2]

There is an association between silica exposure and Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV), but few reports of an association between silica exposure and Immunoglobulin A (IgA) nephropathy.

We describe a case of a stonemason with hilar lymphadenopathy due to silica exposure, ANCA vasculitis and IgA nephropathy.

[dnnikhil]

IgA nephropathy is a kidney condition in which IgA, a protein that helps the body protect itself against external invaders, builds up in the kidneys and causes damage. This reduces their screening ability. As a result, the kidneys begin to leak chemicals into the urine, such as blood and protein. As a result, treatment options focus on controlling immunological and inflammatory processes in the glomerulus and tubulointerstitium. Therefore, many contemporary therapeutic techniques, such as renin-angiotensin blocking, proteinuria reduction, and blood pressure control, are applicable to various kinds of chronic glomerular disorders.

[dataseries]

Unveiling the Competitive Landscape of IgA Nephropathy

In this comprehensive analysis, we delve into the competitive landscape surrounding IgA Nephropathy, shedding light on critical insights that will aid in your understanding of this complex kidney disease and its evolving treatment strategies.

Introduction: Understanding IgA Nephropathy

IgA Nephropathy, also known as Berger's disease, is a chronic kidney disorder characterized by the deposition of immunoglobulin A (IgA) in the glomeruli, leading to inflammation and potential kidney damage. In this article, we embark on a journey to explore the competitive landscape surrounding IgA Nephropathy, providing you with a comprehensive understanding of the market, key players, treatment options, and emerging trends.

Understanding IgA Nephropathy

1. Disease Overview

IgA Nephropathy primarily affects the glomeruli, which are tiny filtering units within the kidneys. The accumulation of IgA deposits in these structures can lead to inflammation and scarring, potentially resulting in kidney dysfunction.

2. Risk Factors

While the exact cause of IgA Nephropathy is not fully understood, certain risk factors may contribute to its development, including:

Genetic predisposition.

Frequent upper respiratory tract infections.

Gastrointestinal illnesses.

Autoimmune factors.

Market Analysis

3. Current Treatment Landscape

The treatment landscape for IgA Nephropathy is multifaceted and aims to slow disease progression, manage symptoms, and prevent complications. Key treatment modalities include:

Immunosuppressive Medications

Immunosuppressants, such as corticosteroids and other immunomodulatory drugs, are used to reduce the inflammation associated with IgA Nephropathy.

Blood Pressure Control

Managing blood pressure is crucial in preserving kidney function. Antihypertensive medications are often prescribed to control hypertension.

Diet and Lifestyle Modifications

Patients are advised to adopt a kidney-friendly diet and make lifestyle changes, including reducing salt intake and maintaining a healthy weight.

4. Key Players in IgA Nephropathy Market

To comprehend the competitive landscape, it's essential to identify pharmaceutical and biotechnology companies actively involved in IgA Nephropathy research and development. Some key players in this space include:

5. Precision Medicine

Advancements in genomics are paving the way for precision medicine approaches in IgA Nephropathy. Tailoring treatments based on an individual's genetic profile holds promise for more effective outcomes.

6. Novel Therapies

Research is ongoing to develop novel therapies targeting the underlying causes of IgA Nephropathy. These therapies aim to modulate the immune response and reduce IgA deposition.

Challenges and Future Prospects

7. Diagnosis and Early Detection

Early diagnosis of IgA Nephropathy remains a challenge. Improved diagnostic tools and increased awareness are critical for timely intervention.

8. Research Collaboration

The future of IgA Nephropathy treatment lies in collaborative efforts between researchers, clinicians, and pharmaceutical companies. Together, they can drive innovation and discover new therapeutic avenues.

Conclusion

In this comprehensive exploration of the competitive landscape surrounding IgA Nephropathy, we've delved into the disease overview, treatment options, key market players, emerging trends, and challenges. Stay informed and vigilant in the evolving landscape of IgA Nephropathy, as advancements in research and treatment continue to shape the future of managing this kidney disorder.

[does-truth-matter]

The CDC has quietly changed who should AVOID the MMR vaccine.

https://www.cdc.gov/vaccines/vpd/mmr/public/index.html

They now state that ANYONE that “Has a parent, brother or sister with a history of immune system problems” should AVOID THE MMR VACCINE!

What exactly is an 'immune system problem?" Every autoimmune disorder.

* Achalasia

* Addison’s disease

* Adult Still's disease

* Agammaglobulinemia

* Alopecia areata

* Amyloidosis

* Amyotrophic lateral sclerosis (Lou Gehrigs)

* Ankylosing spondylitis

* Anti-GBM/Anti-TBM nephritis

* Antiphospholipid syndrome

* Autoimmune angioedema

* Autoimmune dysautonomia

* Autoimmune encephalomyelitis

* Autoimmune hepatitis

* Autoimmune inner ear disease (AIED)

* Autoimmune myocarditis

* Autoimmune oophoritis

* Autoimmune orchitis

* Autoimmune pancreatitis

* Autoimmune retinopathy

* Autoimmune urticaria

* Axonal & neuronal neuropathy (AMAN)

* Baló disease

* Behcet’s disease

* Benign mucosal pemphigoid

* Bullous pemphigoid

* Castleman disease (CD)

* Celiac disease

* Chagas disease

* Chronic inflammatory demyelinating polyneuropathy (CIDP)

* Chronic recurrent multifocal osteomyelitis (CRMO)

* Churg-Strauss Syndrome (CSS) or Eosinophilic Granulomatosis (EGPA)

* Cicatricial pemphigoid

* Cogan’s syndrome

* Cold agglutinin disease

* Congenital heart block

* Coxsackie myocarditis

* CREST syndrome

* Crohn’s disease

* Dermatitis herpetiformis

* Dermatomyositis

* Devic’s disease (neuromyelitis optica)

* Discoid lupus

* Dressler’s syndrome

* Endometriosis

* Eosinophilic esophagitis (EoE)

* Eosinophilic fasciitis

* Erythema nodosum

* Essential mixed cryoglobulinemia

* Evans syndrome

* Fibromyalgia

* Fibrosing alveolitis

* Giant cell arteritis (temporal arteritis)

* Giant cell myocarditis

* Glomerulonephritis

* Goodpasture’s syndrome

* Granulomatosis with Polyangiitis

* Graves’ disease

* Guillain-Barre syndrome

* Hashimoto’s thyroiditis

* Hemolytic anemia

* Henoch-Schonlein purpura (HSP)

* Herpes gestationis or pemphigoid gestationis (PG)

* Hidradenitis Suppurativa (HS) (Acne Inversa)

* Hypogammalglobulinemia

* IgA Nephropathy

* IgG4-related sclerosing disease

* Immune thrombocytopenic purpura (ITP)

* Inclusion body myositis (IBM)

* Interstitial cystitis (IC)

* Juvenile arthritis

* Juvenile diabetes (Type 1 diabetes)

* Juvenile myositis (JM)

* Kawasaki disease

* Lambert-Eaton syndrome

* Leukocytoclastic vasculitis

* Lichen planus

* Lichen sclerosus

* Ligneous conjunctivitis

* Linear IgA disease (LAD)

* Lupus

* Lyme disease chronic

* Meniere’s disease

* Microscopic polyangiitis (MPA)

* Mixed connective tissue disease (MCTD)

* Mooren’s ulcer

* Mucha-Habermann disease

* Multifocal Motor Neuropathy (MMN) or MMNCB

* Multiple sclerosis

* Myasthenia gravis

* Myositis

* Narcolepsy

* Neonatal Lupus

* Neuromyelitis optica

* Neutropenia

* Ocular cicatricial pemphigoid

* Optic neuritis

* Palindromic rheumatism (PR)

* PANDAS

* Parkinson's disease

* Paraneoplastic cerebellar degeneration (PCD)

* Paroxysmal nocturnal hemoglobinuria (PNH)

* Parry Romberg syndrome

* Pars planitis (peripheral uveitis)

* Parsonage-Turner syndrome

* Pemphigus

* Peripheral neuropathy

* Perivenous encephalomyelitis

* Pernicious anemia (PA)

* POEMS syndrome

* Polyarteritis nodosa

* Polyglandular syndromes type I, II, III

* Polymyalgia rheumatica

* Polymyositis

* Postmyocardial infarction syndrome

* Postpericardiotomy syndrome

* Primary biliary cirrhosis

* Primary sclerosing cholangitis

* Progesterone dermatitis

* Psoriasis

* Psoriatic arthritis

* Pure red cell aplasia (PRCA)

* Pyoderma gangrenosum

* Raynaud’s phenomenon

* Reactive Arthritis

* Reflex sympathetic dystrophy

* Relapsing polychondritis

* Restless legs syndrome (RLS)

* Retroperitoneal fibrosis

* Rheumatic fever

* Rheumatoid arthritis

* Sarcoidosis

* Schmidt syndrome

* Scleritis

* Scleroderma

* Sjögren’s syndrome

* Sperm & testicular autoimmunity

* Stiff person syndrome (SPS)

* Subacute bacterial endocarditis (SBE)

* Susac’s syndrome

* Sympathetic ophthalmia (SO)

* Takayasu’s arteritis

* Temporal arteritis/Giant cell arteritis

* Thrombocytopenic purpura (TTP)

* Tolosa-Hunt syndrome (THS)

* Transverse myelitis

* Type 1 diabetes

* Ulcerative colitis (UC)

* Undifferentiated connective tissue disease (UCTD)

* Uveitis

* Vasculitis

* Vitiligo

* Vogt-Koyanagi-Harada Disease

Wonder how many doctors are paying attention?

~shared from Jodi Wilson

[kkelenca]

On top of everything else horrible going on in the world these days, I’ve just learned that a treasured friend’s son has been diagnosed with IgA Nephropathy and is going to need a kidney transplant as soon as they can locate a suitable donor. I know we’ve all been stretched thin for months now, so it feels awful to even mention the link in the face of the other suffering going on right now. 😞

[sshospital]

Understanding Chronic Kidney Disease

Chronic kidney disease (CKD) is a serious condition that affects the kidneys’ ability to filter waste and excess fluids from the body. In India, around 17% of the adult population suffers from CKD. As the disease advances, it can lead to kidney failure, requiring dialysis or a kidney transplant to sustain life.

What is Chronic Kidney Disease (CKD)?

Chronic Kidney Disease is a slow and ongoing decline of renal function for not less than three months. 8% to 16% of the entire global population suffer from diabetes and hypertension.

In its initial form, no sign would indicate the presence of disease. As it develops, the person would be easily diagnosed with fatigue, swelling and other issues such as cardiovascular diseases.

Chronic Kidney Disease Stages

Nephrologists divide the disease into five stages based on the glomerular filtration rate (GFR), which measures how much blood the kidneys can filter per minute.

Stage 1: Normal or High GFR (≥90 mL/min)

The kidneys still function at a normal or high level, with a GFR of 90 mL/min or higher. However, there may be signs of kidney damage, such as protein in the urine. At this stage, symptoms are usually mild or absent.

Stage 2: Mild Reduction in GFR (60–89 mL/min)

Kidney function shows a mild reduction, with a GFR between 60 and 89 mL/min. Symptoms may include frequent urinary tract infections, high blood pressure, and swelling in the hands and feet.

Stage 3: Moderate Reduction in GFR (30–59 mL/min)

This stage is divided into two subgroups: stage 3a (GFR 45–59 mL/min) and stage 3b (GFR 30–44 mL/min). Here, kidney function shows a moderate reduction, and symptoms may include changes in urination, swelling in the hands and feet, weakness, fatigue, dry and itchy skin, back pain, and muscle cramping.

Stage 4: Severe Reduction in GFR (15–29 mL/min)

Kidney function reduces, with a GFR between 15 and 29 mL/min. Symptoms may include anaemia, decreased appetite, bone disease, and abnormal levels of phosphorus, calcium, and vitamin D.

Stage 5: Kidney Failure (GFR <15 mL/min or on dialysis)

Also known as end-stage renal disease (ESRD), this is the most severe stage of CKD. Here, the kidneys fail, with a GFR of less than 15 mL/min, or the patient requires dialysis. Symptoms may include all those mentioned in the previous stages, as well as nausea, vomiting, and confusion.

Causes of Chronic Kidney Disease

Chronic kidney disease symptoms result from many health issues. Understanding the main causes, risk factors, and preventive measures can help mitigate the impact of this disease.

Main Causes of CKD

Diabetes: This leading chronic kidney disease causes results when high blood sugar levels damage the kidneys’ filtering units over time, leading to diabetic kidney disease. Early signs often include protein in the urine, indicating damage to the kidney’s filters.

Hypertension: High BP damages the blood vessels in the kidneys, impairing their ability to filter waste. This creates a harsh cycle, as kidney damage can further increase blood pressure.

Glomerulonephritis: This refers to inflammation of the kidney’s filtering units (glomeruli). Conditions such as IgA nephropathy and lupus nephritis fall under this category and can lead to kidney damage.

Polycystic Kidney Disease (PKD): A genetic disorder characterised by the growth of a large number of cysts in the kidneys, PKD can badly affect kidney function over time.

Recurrent Kidney Infections: Chronic infections can lead to scarring and damage to the kidneys, contributing to CKD.

Obstructive Uropathy: Conditions like kidney stones or an enlarged prostate can obstruct urine flow, causing kidney damage.

Toxic Substances: Long-term exposure to certain medications (like NSAIDs) and heavy metals (like lead) can harm the kidneys.

Risk Factors Associated with CKD

Many factors can increase the likelihood of developing the disease:

Family History: A genetic predisposition to kidney disease can increase risk.

Age: The risk of chronic kidney disease increases with age, particularly in individuals over 60.

Ethnicity: Certain ethnic groups, including South Asians and African Americans, face a higher risk for CKD.

Conclusion

Chronic kidney disease remains a public health concern, especially in India, where a large portion of the adult population is affected. The progressive nature of CKD highlights the urgent need for early detection and management to prevent its escalation into end-stage renal disease, which requires intensive treatments like dialysis or kidney transplantation.

Regular check-ups with nephrologists at the best hospital In Haryana, such as SS Kidney Hospital, are important for those at risk or diagnosed with CKD to monitor kidney function and manage symptoms.

[newsheadlinesnow]

IgA Nephropathy Market to Show Remarkable Growth Trends from 2024 to 2034, DelveInsight Reports | Novartis, Vera Therapeutics, RemeGen Co., Ltd., Anthera Pharma, Chinook Therapeutic, Ionis Pharma

http://dlvr.it/TCpvZW

[thealphareporter]

IgA Nephropathy Market to Show Remarkable Growth Trends from 2024 to 2034, DelveInsight Reports | Novartis, Vera Therapeutics, RemeGen Co., Ltd., Anthera Pharma, Chinook Therapeutic, Ionis Pharma

http://dlvr.it/TCppPg

[thesunshinereporter]

IgA Nephropathy Market to Show Remarkable Growth Trends from 2024 to 2034, DelveInsight Reports | Novartis, Vera Therapeutics, RemeGen Co., Ltd., Anthera Pharma, Chinook Therapeutic, Ionis Pharma

http://dlvr.it/TCpnHy

[conversationpoint]

IgA nephropathy Clinical Trials Analysis 2024: FDA Approvals, Pipeline, Therapies, Treatment Market and Key Companies by DelveInsight

http://dlvr.it/T9PkWg

[columbianewsupdates]

IgA nephropathy Clinical Trials Analysis 2024: FDA Approvals, Pipeline, Therapies, Treatment Market and Key Companies by DelveInsight

http://dlvr.it/T9Pjkb

[universalnewspoint]

IgA nephropathy Clinical Trials Analysis 2024: FDA Approvals, Pipeline, Therapies, Treatment Market and Key Companies by DelveInsight

http://dlvr.it/T9Pgv6