#minibinder

[alenasbdesign]

Happy Repentance Day, Saxony!

[demouma]

My volo cards came in

[kintatsujo]

hunting online for the perfect minibinder but it won't fill the hole in my soul (what I actually want is a soft reusable leather cover I can wrap around my existing spiral notebooks so they stop getting all beat up in my bags)

[equallyreal]

Transmission Received: Writing is still in limbo, as you've probably guessed from the way this update is eight days late. That said, I'm hoping next month will jumpstart things a little! Due to all the nonsense, I won't be participating in NaNoWriMo. As mentioned in another post, I'm going to be doing Notebook November instead. I just have to pick a notebook...which is harder than you'd think. I have a lot of notebooks. I have another one coming in, actually, but I'm going to use that for worldbuilding stuff since it's more of a minibinder. I'll keep everyone posted on how the writing goes, and if you're participating as well, let me know!

I may also start doing more frequent updates to keep myself accountable, but I don't want to make any promises about that. No sense in shooting myself in the foot over something that's mostly supposed to be fun.

Have a Happy Halloween, everyone!

[fantabulousblog]

Wood Owl with big eyes Mini Binder #backtoschool #stationery #officeorganization #minibinder #woodowl #cutebinder #schoolsupplies

[basx2]

[littlecrafter]

@sassyplanner_co super cute mini binders are now available and part of the Flash Sale. They come with a plastic pouch and 90 sheets of paper. The cover is doubled so you can add in a small dashboard or picture.They come in a few different colors and are perfect to drop in your purse for on the go. #minibinder #sassyplanner_co #listholder #minijournal #miniplanner #minicutebinder #onthego #flashsale (at Brooklyn, New York) https://www.instagram.com/p/CXrD6SFpug1/?utm_medium=tumblr

[ayujaded]

These are my recent collages for the maknae line and love how they turn out to be. It is not the usual lettering or other much popular styles but this is my style in making spreads. A shout out to all the ARMY out here! You are welcome to check out my other spreads on my IG page at: poetessemo

[clitstitsandkittens]

#mailgoodies 💕📔🖊 #leuchtturm1917#leuchtturm#zebra#zebramildliner#binder#minibinder#staples#amazon#mail#googles#hobonichi#bulletjournal#journal#journaling#planner#plannerjunkie#planneraddict#journaljunkie#pen#pens#penobsession#collecting#socute#inlove#teenytinykat#kittentokat#ashleykat

[diy-and-crafts-awesomenes]

Mini-blind Makeover… take some cheap mini blinds and turn them into custom shades with your favorite fabric. #minibinds #makeover #howto #tutorial #romanshades #shades #fabric #windows #diy #diyproject | Like My Facebook Page >> https://ift.tt/2jty87z ... Saved from - https://ift.tt/3b7Y7uc

[badmoodmonday-blog]

Another sneak peek of some of our new releases coming this week! New functional sticker options, fun and funky prints, and mini binder cover stickers! 😍😍😍 #functionalstickers #stickerbook #minibinder #stickerboss #stickershop #plannerstickers #girlboss #creativeplanning #memoryplanning #ec #eclp #newreleases #sneakpeek #stickerlove #etsyshop #etsy

[curlytea]

I repurposed a Target #minibinder pocket to use in my #study notebook. 😊 Try to line up the center hole of the pocket to the center of the Cinch tool. (I think it was at the 6 hole mark) This #Cinch #bindery tool sure has come in handy af this year. I've made a full #planner and a #studynotebook using it. 🖒 #DIY #studying #stationery #studyblr #studygram #target #pocket #spiralnotebook #notebooks #planning #studytracker #studytools #plannertools #journals

[cskyan]

Targeting the interaction between the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and the human angiotensin-converting enzyme 2 (ACE2) receptor is a promising therapeutic strategy. We designed inhibitors using two de novo design approaches. Computer-generated scaffolds were either built around an ACE2 helix that interacts with the spike receptor binding domain (RBD) or docked against the RBD to identify new binding modes, and their amino acid sequences were designed to optimize target binding, folding, and stability. Ten designs bound the RBD, with affinities ranging from 100 picomolar to 10 nanomolar, and blocked SARS-CoV-2 infection of Vero E6 cells with median inhibitory concentration (IC50) values between 24 picomolar and 35 nanomolar. The most potent, with new binding modes, are 56- and 64-residue proteins (IC50 ~ 0.16 nanograms per milliliter). Cryo–electron microscopy structures of these minibinders in complex with the SARS-CoV-2 spike ectodomain trimer with all three RBDs bound are nearly identical to the computational models. These hyperstable minibinders provide starting points for SARS-CoV-2 therapeutics.

[oo0owo0oo]

it hasnt come in yet but im going to try solving this with one of those really pretty minibinders and stationary papers. i can remove or scribble on pages that i dont want or need and keep anything that feels important.

The paralyzing fear of writing something in a blank journal is magnified tenfold when it’s one of those leatherbound ones with cotton paper pages. It feels unworthy to put anything in it that isn’t the diary of your expedition thousands of miles from civilization, with sketches of the mysterious artifacts you found along the way.

[un-enfant-immature]

$3M Breakthrough Prize goes to scientist designing molecules to fight COVID-19

The Breakthrough Prize Foundation announced $21.75 million in awards today for a variety of scientific achievements. One in particular is a tech/science crossover: A $3M award to David Baker, whose work over the last 20 years has helped validate the idea that computers can help us understand and create complex molecules like proteins — and the latest such molecule may lead to new treatments for COVID-19.

Baker is the head of the Institute for Protein Design at the University of Washington, and for two decades has helped explore and define the field of computer-aided molecular biology. His lab developed the Rosetta software for modeling the immensely complicated folding and other interactions of proteins, and also the FoldIT distributed computing network for spreading the task around to eager citizen scientists.

As Bakers says: “We could wait another million years for the protein we need to evolve, or we could design it ourselves.”

The prize is specifically for “For developing technology that allowed the design of proteins never seen before in nature, including novel proteins that have the potential for therapeutic intervention in human diseases.” This acknowledges Baker and his colleagues’ role in the technology as a whole, but his latest work may prove his most widely consequential: a bespoke molecule made specifically to blunt the sharp spikes of the novel coronavirus.

It’s the molecular equivalent to putting a scabbard on a sword. The only problem is that the sword doesn’t come with the scabbard — you have to make it yourself. And that’s a lot more complicated than it sounds, since there are so many factors in how the amino acids, atoms and bonds interact between the two. Fortunately that’s exactly the problem Baker and his team have been building a platform to solve.

The red molecule is the minibinder, attached to the blue coronavirus protein. Image Credits: David Baker / UW

“We have developed general design methods for creating proteins from scratch that are complementary in shape and chemical properties to arbitrary target sites,” Baker told TechCrunch. “We simply pointed these at the virus spike!”

The “de novo” proteins created and tested by the team bind strongly to the spike protein and don’t let go — hence their name, “hyperstable minibinders.” It’s no miracle cure, but it could be the start for a therapeutic approach that disables the virus’s method of spreading — once it’s been properly tested, of course.

“The designed protein described in the Science paper published today is looking very promising,” Baker said. “We are doing pre-clinical experiments to determine whether it could be an effective drug as is or needs to be modified.”

He also noted that “FoldIT players and Rosetta@home participants have been making important contributions to our anti-COVID efforts,” so good job if you’ve been donating computer cycles to the project.

You can see the many other prizes awarded this year, in topics such as Mathematics and Fundamental Physics, at the foundation’s news post here.

The Breakthrough Prize Foundation was originally born from the efforts (and coffers) of Yuri and Julia Milner, and the prize for Life Sciences is co-sponsored by Sergey Brin, Priscilla Chan and Mark Zuckerberg, Pony Ma and Anne Wojcicki.

[nuggetsofrandomness]

Family Reunion Band Retro 70s Concert Logo Neon Mini Binder #familyreunionconcert #MiniBinder #retrocraftsupplies #retroparty https://ift.tt/35LqpIp