#non frnk related

[frnkiebby]

his stupid pretty smile~🎃

[carriagelamp]

February 2020 Book Review

The Last Wish / Sword Of Destiny

Let’s start with the books that currently have me in a stranglehold. I apologize to everyone that actually follows me and watched me descend into fandom pits but whatcha gonna do. So, I was aware of the video game when it came out, but not being a prolific gamer I was intrigued but never bothered getting into it. Then the Netflix series came out, and I was again intrigued... but I suck at sitting down and watching shows. So what the heck I decided, it’s probably mediocre hypermasculine high fantasy but let’s try a book to see what the fuss is all about.

Good god. Guys. It’s real good. And so fucking different from the show. Geralt is actually a really emotional, well-meaning guy who’s starved for positive social interactions and is just trying to do his best. And the books’ consistent themes of colonialism, environmental destruction, forced extinction, and changing eras is... chilling and fascinating and honestly a little too relatable at times. These books have made me laugh and shout and frankly sob. Still a little sexist, cause 90s fantasy, but Geralt is so not the gruff, heartless, manly man character I thought he would be. I am so deeply into these and have just cracked the spine of the next book in the series. If you like high fantasy, I can’t recommend these enough.

The Silver Eyes

I just learnt that there were Five Nights At Freddy’s books, and honestly picked this up from the library as a joke for my brother. We’d played the games back when they first came out, and were into the lore, but lbr they’re more of a meme at this point. Anyway, we ended up reading this out loud to each other, a chapter a night, and I enjoyed it a lot more than I thought I would. Probably wouldn’t have liked it as much on my own, but the main character was complicated and messy, and the book’s way or portraying trauma was neat. It was nominally horror, and did have the occasional chilling moment, or times it was fun to speculate, it over all it was pretty run of the mill middle grade fiction.

FRNK

Probably the best graphic novel I’ve read this month. 

I was howling with laughter while I read it. Good quality Belgium comics, always a treat. This story is about a modern day boy, Frank, who is accidentally thrown back into prehistoric times, where he’s stuck with a bunch of cavemen who haven’t invented the concept of vowels yet. Admittedly my French isn’t great, so it made trying to decipher words with half the letters missing a challenge to say the least, but plenty worth it. I really want to get my hands on book two. I believe there’s an English translation, and I’d recommend giving it a try.

Best Friends

A neat little graphic novel that addresses common growing up issues, about what it means to be friends, stay friends, how to cope with people changing and when it’s time to walk away. Anxiety, being yourself, fitting in, all that sort of stuff. It’s a quick read, very pleasant, and has nice art.

Karen’s Witch

Another cute graphic novel with charming art. I read this at the store while I was waiting for a prescription to be filled. It’s about this five year old (or thereabouts) who is absolutely determined that her neighbour is a witch and by god she is going to prove it or at least scare herself and her friend silly in the process. A fun little read!

Endling: The First

The second book in the Endling series, and all my praise for the first book apply here as well. A super unique high fantasy that gives extinct and threatened species a voice. The book explore themes of war, environmental destruction, sacrifice and loss. You really get to see how much Byx has grown and how much she needs to continue to grow. This book has me so excited for the third, I haven’t read such an emotionally rewarding quest novel in a long time.

Bleach

I found out my library has a billion books of this series and decided to jump into it again for the first time in over a decade. Honestly it’s even better than I remembered? The art is absolutely stunning, Ichigo is such a power fantasy hero, and it’s one of those series with a lot of really loveable characters and a lot of heart. Ichigo is a good guy who you actually feel good liking, which can’t be said for all shonen protags by any means. This is just such a classic and it holds up man. And if you like manga and have never read it? Jump in and enjoy a normal human getting supernatural powers and kicking absolutely enormous monsters’ asses.

Dinotopia: Sabertooth Mountain

This was my favourite Dinotopia book as a kid, and it was still fun to reread. The world of Dinotopia is one separate from the rest of the world, where humanity lives in perfect harmony with many prehistoric creatures that have managed to survive and evolve on the island of Dinotopia. This story is about a crisis brewing, as the sabertooths are cut off from their food supply and are in danger of not only starving but of bringing death to the rest of the mountain as well. While surveying the situation with his older sister, the main character finds himself falling from the airship in the middle of a storm, directly into the valley of starving sabertooths.

I read a bunch of this author’s graphic novels, and they are such feel-good queer lit. This was probably my favourite of the lot, but I also read Tea Dragon Society, Aquicorn Cove, and Princess Princess Ever After. Taking place in a picturesque mountain community, it’s about a girl meeting a guardian dragon who accidentally fell asleep in the mountains a century ago rather than watch over the village like intended. It’s about coming to terms with and loving yourself (and also about super cute little tea dragons).

Just Jaime

Another story that focuses on the complications of middle school, and how friends can grow and change, and when sometimes friendships become toxic and cruel. These are novel/graphic novel hybrids that are very visually appealing, and really do manage to tell very heartfelt stories. This one takes a side character from the earlier two books, and turns her from a very one dimensional, somewhat annoying character, into a fully realized person with her own issues and her own need for growth.

The Life-Changing Magic Of Tidying Up / The Life-Changing Manga Of Tidying Up

Given that I’m not really a non-fiction person and DEFINITELY not a self-help book person, I really enjoyed these (though I didn’t read Spark Joy). I read the manga first, out of curiosity, but enough of it struck true that I decided to try the book as well. Have I cleaned anything up yet? No. But honestly, I can genuinely say that despite being repetitive at points I do truly feel like I got a lot of good out of it, and I feel much more excited and prepared when I do decide to do a big clean next. It really does reframe the relationship you have with your belongings and with yourself. I genuinely love the concept of “sparking joy”.

Bigfoot Boy: The Sound Of Thunder

Technically the last book of the series, whoops. Though honestly having read it I didn’t feel like I missed that much. It’s a Canadian graphic novel and I had... mixed feelings about it. Interesting and exciting in some ways, but the pacing was odd, and honestly I don’t think indigenous voices went into making it (I could be wrong but...) and it reads as kinda... eugh. Problematic. Having a none indigenous author write about a white boy being the guardian of a first nation totem and turning into a bigfoot isn’t a super cool optic.

Bloodchild

I was told “hey this is a really fucked up short story” so I read it, and guess what? It was a really fucked up short story. Would recommend if you want weird alien sex slavery bullshit-- it was a wild ride. And the overall themes obviously went a lot deeper than that, but honestly, it’s like a few dozen pages long if you wanna dig into all the philosophical shit, just give it a read! Uh, heavy content warning, tw tw tw, but a really bizarre, unsettling look at gender and power dynamics and oppression through a scifi lens.

Mrs Frisby and the Rats of NIHM

I hadn’t read this book since elementary school so I reread it on a whim. It really is such a charming story. As far as animal stories go, this feels almost like the platonic ideal. Mother mouse is worried about her sick son and winds up compelled to seek out the mysterious rats who live in the rosebush for help, and is not only thrust into her own adventure but learns about the strange past her late husband shared with the rats of NIMH. It’s such a relaxing read, while still managing to be exciting and compelling.

Exploring According to Og the Frog

And one last animal story to round us off. I’d read one of the Humphrey books last month, and check out a couple more from the library for fun. I didn’t enjoy Mysteries According to Humphrey that much, but this one was charming, showing the world through Humphrey’s frog friend Og instead. The same charming type of adventure, but being a frog, Og has a very different attitude and view of the world, which was fun. Very cute elementary kid lit.

[cancersfakianakis1]

Therapeutic Potential of Focal Adhesion Kinase Inhibition in Small Cell Lung Cancer

Small cell lung cancer (SCLC) has a poor prognosis. Focal adhesion kinase (FAK) is a non–receptor tyrosine kinase regulating cell proliferation, survival, migration, and invasion, which is overexpressed and/or activated in several cancers, including SCLC. We wanted to determine whether FAK contributes to SCLC aggressive behavior. We first evaluated the effect of FAK small-molecule inhibitor PF-573,228 in NCI-H82, NCI-H146, NCI-H196, and NCI-H446 SCLC cell lines. PF-573,228 (0.1–5 μmol/L) inhibited FAK activity by decreasing phospho-FAK (Tyr397), without modifying total FAK expression. PF-573,228 decreased proliferation, decreased DNA synthesis, induced cell-cycle arrest in G2–M phases, and increased apoptosis in all cell lines. PF-573,228 also decreased motility in adherent cell lines. To make sure that these effects were not off-target, we then used a genetic method to inhibit FAK in NCI-H82 and NCI-H446, namely stable transduction with FAK shRNA and/or FAK-related nonkinase (FRNK), a splice variant lacking the N-terminal and kinase domains. Although FAK shRNA transduction decreased total and phospho-FAK (Tyr397) expression, it did not affect proliferation, DNA synthesis, or progression through cell cycle. However, restoration of FAK-targeting (FAT) domain (attached to focal adhesion complex where it inhibits pro-proliferative proteins such as Rac-1) by FRNK transduction inhibited proliferation, DNA synthesis, and induced apoptosis. Moreover, although FAK shRNA transduction increased active Rac1 level, FRNK reexpression in cells previously transduced with FAK shRNA decreased it. Therefore, FAK appears important in SCLC biology and targeting its kinase domain may have a therapeutic potential, while targeting its FAT domain should be avoided to prevent Rac1-mediated protumoral activity.

http://bit.ly/2SvjDjB