#multiformed

[horizonmet]

"... Aye," he lets out a sharp breath through his nose, admitting to having barely been able to get away from that HEINOUS aftermath, and with the help of a then-Highwind. "A long time ago, when I was much younger, I was attacked by one of 'her' extensions. I turned my back on the body, thinking that the fight was over... it was not." he frowns slightly, recalling the moment where he had almost lost it all, and all because he had gotten GREEDY.

he tilts his head in an almost dismissive manner ; it truly didn't matter anymore, as most ( if not all ) people couldn't tell that he was still mostly a higher ranked Nobody, rather than a Somebody with a mood disorder that made him unable to recognize or show emotions. it made things a little easier, to explain at least. "True Darkness is not what this is." he says with a plain tone, locking the cabinet and turning back to master xehanort.

"I'm sure you have questions. Go ahead and ask. I'll tell you if I don't know, or if I can't answer." his smile is stilted, awkward, as if he's relearning how to show emotions. "If you need anything, just let me know. I wouldn't be a good doctor, if I left a patient in pain while out and about."

"Either or, I suppose."

His vision trailed over to the cabinet, watching as the other put away the creepy blight. Curiosity definitely stayed present within his sight - though he knew he had to resist. He looked away from it sharply. "Recover? It had infected you, or are you speaking metaphorically?" He kept his sight on some cabinet elsewhere - trying to find something to catch his attention. A parent shoving affection onto their child - through affection. Unsurprising. Even if he couldn't relate ...

He blinked at the information ; the horror dawned on an inch further. "Mind control to the supernatural degree,'' he muttered, finding the concept somewhat alluring in itself. But at the same time, it would hardly mean external control would be allowed.

"Sounds like it could be related to what is called 'True Darkness'. A persistent form of darkness that lurks around."

For once, he didn't mean any offense - even though a hand protectively stayed there covering his stomach - fearing as if it could infect again so easily. It made the hairs on the back of his neck stand up. He snorted upon hearing such bits.

"And considering I already extend my mana out towards others .. that could have gone south incredibly quick,'' he muttered, half to the other, half towards himself. But he wasn't about to elaborate on the complexities on such a thing - the other didn't need to know of the Organization.

[nickpeppermint]

When i GET YOU

An art trade with @batdogduke

[wieldingtwilight]

"My ambition, hm." The younger exhales through his nose, stepping closer to his older self, "..maybe you're right."

He stares at his older self for a long moment, as if trying to put something together in his own mind, but coming up short on whatever that might be. As his eyes turn away to make sure no onlookers are spying on them, his voice comes out quiet.

"It was a smart move, I'll give you that much. I have to wonder.." He looks back at himself, "What injured you? I don't imagine in your age that you're going out picking duels with the others, so what happened?"

.. even his younger self ..? Then again, he really should expect it - especially after the certain incident. Something utterly dark had churned within him after all that. Unless, he was misremembering, which is entirely a possibility.

Eyes widen just a hair -- indeed curious at such a proposal himself. ''..t-than your ambition w-wouldn't be fulfilled .." It's a near whisper - in order to preserve his strength. Even if it seemed a cruelty right back. To remind his Other of a failure.

An uneven breath stuttered, and he coughed as last of blood came up his throat onto the ground. A hand tiredly finally fell to his side, and he pressed his back against a wall nearby. He shot another scowl -- his body still feeling weakened despite being healed. "And you forget - A little manipulation goes far."

He coughed again, it feeling dry. ".. but all more reason to have sought you out instead."

[getoutofthisplace]

Dear Gus & Magnus,

When Gus left the Museum of Discovery yesterday afternoon, he said he had spots on his legs. Mom and I looked at them and decided he was having some kind of reaction, but it hadn't shown up on his face and he said he felt normal, so we decided to give him some Benadryl and keep an eye on it. This morning, though, he woke me up and said he didn't feel normal. It had spread to his face and mouth, so Mom took him to the emergency department (which is apparently the new name for the emergency room). Diagnosis: Erythema multiforme, possibly caused by the strep he had a couple of weeks ago, or another virus, or the antibiotic he took for strep, or few other things, but it shouldn't cause any respiratory problems. The doctor put him on a steroid and said he could go back to camp, but he wanted to stay home with Mom. I would have too.

The whole experience reminded me of when he had a similar reaction as a baby.

Monkel and Will joined us for steaks on our porch, then the three of us went to Riverdale Theater to watch The 'Vous, a documentary about The Rendezvous in Memphis. Bryan was the film's director of photography. A solid night.

Dad.

Little Rock, Arkansas. 6.4.2024 - 6.11am.

[comicchannel]

Metroid Dread Samus and E.M.M.I. - Nintendo Amiibo Collection

Link para compra BR: https://amzn.to/3Oy2W5Z

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[newmusick]

i want that hot dog ....the bun not so much... but that meat is my heaven chad ... the snake was not in the picture ...thanks too google edit now you can remove all those pesky family members from your memory's ....thank you google ! the new life edit function is just amazing to say the least just look that these results ... just a shadow remains

what else can i say .... just brilliant ..an evocation ? staying alive is the plan

can y9o0u feel

one of these faces could be yours ....

[soulthom]

Depuis des années je dénonce le néo-féminisme, l’identitaire tous azimuth, et la facticité totale du politique aujourd’hui et voilà le résultat :

[mordormr]

Glioblastoma Multiforme Treatment Market: Trends, Challenges, and Future Outlook

Market Overview

The Glioblastoma Multiforme Treatment Market is projected to be valued at USD 3.02 billion in 2025 and is expected to grow to USD 4.44 billion by 2030, registering a CAGR of 8% during the forecast period (2025-2030). 

Key Trends Driving the Market

1. Rising Adoption of Targeted Therapies and Immunotherapy

Monoclonal antibodies (mAbs), checkpoint inhibitors, and personalized cancer vaccines are gaining traction for GBM treatment.

Immunotherapies like PD-1/PD-L1 inhibitors and CAR-T cell therapy show promise in clinical trials, offering a potential breakthrough.

2. Advancements in Tumor-Treating Fields (TTF) Technology

TTF therapy, such as Optune®, has revolutionized GBM treatment, prolonging survival by disrupting tumor cell division.

Non-invasive and combinational approaches are being explored to enhance TTF effectiveness.

3. Expanding Research in Gene Therapy and Oncolytic Viruses

CRISPR-based gene editing and viral vector therapies are under investigation to target GBM at the molecular level.

Oncolytic viruses like DNX-2401 are being tested for their ability to selectively destroy tumor cells while stimulating the immune system.

4. Increase in Clinical Trials and Drug Development

Pharmaceutical and biotech companies are investing heavily in clinical trials for novel GBM drugs and combination therapies.

Precision medicine and biomarker-driven treatment strategies are improving patient selection and therapy response.

5. Growing Use of AI in Drug Discovery and Treatment Personalization

Artificial intelligence (AI) and machine learning are accelerating GBM drug development and radiotherapy planning.

AI-powered tumor imaging and genomic profiling are enhancing early diagnosis and treatment decisions.

Challenges in the Glioblastoma Multiforme Treatment Market

1. Poor Prognosis and High Recurrence Rates

GBM is highly aggressive, with an average survival of 12-15 months post-diagnosis.

High recurrence rates and resistance to standard therapies make long-term disease management difficult.

2. Limited Treatment Options and High Costs

Current treatments (radiation, chemotherapy, and TTF) only provide temporary relief, with no definitive cure.

High costs of advanced therapies like targeted drugs and immunotherapy limit accessibility, especially in low-income regions.

3. Blood-Brain Barrier (BBB) Challenges

The BBB restricts drug delivery to the brain, reducing treatment effectiveness.

Research is focused on nanotechnology-based drug delivery and BBB-permeable therapies to improve outcomes.

4. Regulatory and Clinical Trial Hurdles

GBM drug development is challenging due to strict FDA and EMA regulations, delaying new treatment approvals.

High failure rates in late-stage clinical trials pose a risk for biotech firms and investors.

Conclusion

The glioblastoma multiforme treatment market is evolving with advancements in targeted therapy, immunotherapy, and AI-driven precision medicine. While challenges like high recurrence rates, BBB limitations, and treatment resistance persist, ongoing clinical trials, gene therapy innovations, and AI-driven drug discovery are paving the way for improved patient outcomes. As research and investment in GBM treatments continue to grow, the future holds promise for more effective, personalized, and accessible treatment options.

For a detailed overview and more insights, you can refer to the full market research report by Mordor Intelligence: https://www.mordorintelligence.com/industry-reports/glioblastoma-multiforme-treatment-market

[primepaginequotidiani]

PRIMA PAGINA Unita di Oggi martedì, 07 gennaio 2025

[industrynewsupdates]

Exploring Glioblastoma Multiforme Treatment Market : Trends and Future Outlook

The global glioblastoma multiforme treatment market size is expected to reach USD 5.10 billion by 2030, according to a new report by Grand View Research, Inc. It is expected to expand at a CAGR of 9.7% from 2023 to 2030. The market is driven by the rising prevalence of the disease and increasing approval for novel therapy and combination therapy.

In recent years, the industry has been growing rapidly owing to the introduction of innovative products and rising interest of major pharmaceutical companies in the market due to favorable guidelines and rising incidence of the disease. For instance, companies such as Bristol Myers Squibb; CNS Pharmaceuticals, Inc.; and Bayer have novel products in the pipeline for glioblastoma multiforme. These products are likely to boost competitive rivalry in the market in the coming years.

Moreover, companies are collaborating to develop novel treatments. For instance, in October 2019, Advaxis, Inc., a clinical-stage biotechnology company, announced a research collaboration agreement with the University of California for the development and commercialization of novel immunotherapy by using the company’s Lm Technology in mouse tumor models of glioblastoma multiforme. An increase in collaborations between researchers and market players is expected to boost the development of novel and effective treatment options for glioblastoma multiforme.

Existing companies are willing to acquire new companies with pipeline products to diversify their product portfolio. For instance, in May 2019, Merck announced the upfront USD 1.1 billion acquisition of Peloton Therapeutics, which grants it access to the PT2977 under trial glioblastoma drug. This acquisition is likely to strengthen its pipeline and improve its future revenue-generation ability.

Gather more insights about the market drivers, restrains and growth of the Glioblastoma Multiforme Treatment Market

Glioblastoma Multiforme Treatment Market Report Highlights

• Based on treatment, in 2020, radiation therapy dominated the market with a revenue share of 37.0% in 2022, owing to improved survival rates, as radiation therapy is most often recommended as the first line of treatment or in combination with chemotherapy and surgery

• By drug class, the others segment accounted for the largest revenue share in 2022. The segment includes everolimus, corticosteroids, and 5-aminolevulinic acid (5-ALA)

• The hospital segment held the largest revenue share in the glioblastoma multiforme treatment market in 2022 and is anticipated to maintain its leading position during the forecast period. Patients prefer hospitals in terms of treatment accessibility and convenience

• Asia Pacific is expected to register the fastest growth rate of 11.1% over the forecast period, owing to various factors such as the entry of generics of temozolomide in the market, improving economy, rising geriatric population, and growing investments in the healthcare sector

• North America accounted for the largest share of 43.4% in 2022. Government support for the development of the healthcare sector, high awareness about rare disorders, easy accessibility to quality medical facilities, and favorable reimbursement policies are among the key factors responsible for the regional market growth

Glioblastoma Multiforme Treatment Market Segmentation

Grand View Research has segmented the global glioblastoma multiforme treatment market on the basis of treatment, drug class, end-use, and region:

Glioblastoma Multiforme Treatment Outlook (Revenue, USD Million, 2018 - 2030)

• Surgery

• Radiation Therapy

• Chemotherapy

• Targeted Therapy

• Tumor Treating Field (TTF) Therapy

• Immunotherapy

Glioblastoma Multiforme Treatment Drug Class Outlook (Revenue, USD Million, 2018 - 2030)

• Temozolomide

• Bevacizumab

• Lomustine

• Carmustine Wafers

• Others

Glioblastoma Multiforme Treatment End-use Outlook (Revenue, USD Million, 2018 - 2030)

• Hospitals

• Clinics

• Ambulatory Surgical Centers

Glioblastoma Multiforme Treatment Regional Outlook (Revenue, USD Million, 2018 - 2030)

• North America

o U.S.

o Canada

• Europe

o UK

o Germany

o France

o Italy

o Spain

o Denmark

o Sweden

o Norway

• Asia Pacific

o Japan

o China

o India

o Australia

o Thailand

o South Korea

• Latin America

o Brazil

o Mexico

o Argentina

• Middle East and Africa

o Saudi Arabia

o South Africa

o UAE

o Kuwait

Order a free sample PDF of the Glioblastoma Multiforme Treatment Market Intelligence Study, published by Grand View Research.

[eternal--returned]

Nor was Rothko's attraction to these medieval prototypes limited to their formal qualities; their propulsive narrative came into play as well. In that same rich essay of 1947, he stated:

I think of my pictures as dramas; the shapes in the pictures are the performers. They have been created from the need for a group of actors who are able to move dramatically and execute gestures without shame.

Actors typically perform before a backdrop. A few years after the appearance of Primeval Landscape, Rothko embarked on a series of larger canvases he dubbed his 'Multiforms', of which the 1947 No. 21/Untitled is an excellent representative example. The operation he performed on his Mozarabic schema essentially consisted in bringing its background forward into the active role, while the foreground creatures that dominated a work like Primeval Landscape recede into flickering, marginal visibility. In effect, his backgrounds had ingested them, multiplied, and become active rather than passive. Rothko finds himself caught for a time in an oscillation between these poles of emphatic shapes and emphatic contours, survivals of a figure-ground pictorial syntax. A work like Untitled (Multiform) of 1948 reverts to the drawing of outlines, though these now tend to resemble haloes more than confining edges. This device, however, points toward the next plateau in this development: Rothko's mature format had to contain both qualities in tense but roughly equal balance, that is, the consolidation of these somewhat placeless and slack shapes—neither taut in their geometry nor truly unconfined—into larger forms by in effect sliding them one behind the other, lending them a depth that no single color arc or shape could exhibit on its own. The large upper rectangle in No.7/No. 11 of 1949, predominantly pale green, suspends itself like a veil over a darker patch of almost indeterminate hue. The lower half of the canvas, however, still retains the busier proliferation of actors, even if they are more obediently stacked in parallel to one another and to the dominant rectangle above.

Thomas Crow ֍ "Illuminations Past and Present in the Painting of Mark Rothko." Toward Clarity (2019)

Mark Rothko ֍ No. 21 / Untitled (1947)

Mark Rothko ֍ Untitled (Multiform) (1948)

Mark Rothko ֍ No. 7/No. 11 (1949)

[deafsapphic]

hi welcome to my thoughts

today marks the one year anniversary of your emergency craniotomy. the day i found out that, no, it’s not just a hole in your head. it is a glioblastoma multiforme. and it will ruin your body, spirit, and soul for the next 9 months until it eventually takes your life in a nursing home. alone. no one around you. and your husband is so fucked in the head by your sudden death that he takes it out on the resident nurses that were charged with your care that night, and not on the incredibly aggressive tumor that had quickly been sucking the life from your body and spunk from your personality until you were nothing but a shell to the world and to the people you cared about the most.

the tumor attacked on December 1st, and continued to attack despite the radiation , despite the chemo, and despite the fight you so surely held together for so long. it chipped away at you like stone. you inevitably caved in to the carving, regardless of its malevolent intentions. i miss you everyday. there isn’t one day where i don’t think of you, or see your face. i hear your favorite quips like a rundown cable tv box. i don’t care. i want it endlessly. “trixx are for kids, you’re a chip off the old brick”. i miss you. i love you. i hope you’re at peace.

[radiomogai]

[PT: Multiform Flag. End PT]

Multiform Flag

Multiform “a plural/system that has/is multiple collectives/forms of collectives in some way”

this is a um pretty self indulgent coin ,,

tags: @radiomogai

[justjensenanddean]

You say the headaches are worse? Just more frequent. I don't know about worse. But no lack of balance, dizziness, uh, vomiting? Not yet. (...) I'm not telling you anything that I didn't already tell you nine months ago. With this aggressive form of glioblastoma multiforme, the risks of surgery or radiation are… they outweigh the benefits. Yeah, no, I know. I'm just, uh… just looking for a little relief. I will up the dosage of your medication. I will continue with regular MRIs to assess the progression of the tumor. But I don't think we can tell... [speaks indistinctly]

Jensen Ackles as Mark Meachum COUNTDOWN (2025) | 1.01 – “Teeth in the Bone”