#AJ 1 High MM
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snkrbonbon · 1 year ago
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Air Jordan 1 High MM
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megalizardon4736 · 9 months ago
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Zoe Patel Makeover 💜
Defaults -
Beetle Eyes 2 by squeamishsims
No EA Lashes by Kijiko
Hair -
Yennefer Hair v2 by manul-sul-sul
Teresa Hair by sehablasimlish (thesimsresource)
Artemis Hair by qicc (thesimsresource)
Eyebrows -
Updated Stretchskeleton Eyebrows by whoismae
Eyes -
Contacts #68 by sims3melancholic
Eyelash v4 by MMSIMS
Skin Details -
Skin n6 Overlay by northern siberia winds
FEMALE TORSO MASK N3 MM OVERLAY by northern siberia winds
Nose Masks by RemusSirion (thesimsresource)
Nose Tip Nose Mask by obscurus-sims
Moomoo Blush by squeamishsims
Blush n8 Lips by northern siberia winds
Makeup -
Nail It! Nail Set 2.0 by Joliebean
Kendell Eyeshadow by crypticsim
Saffron Liner by crypticsim
Neutrals vol 1 eyeshadow by crypticsim
Blush n8 by poyopoyo
Sour Fruit Lipstick by TwistedCat
Wedding Lipstick by TwistedCat
Shell Dust Eyeshadow by faaeish
Protoplast Lipstick by RemusSirion (thesimsresource)
Vanilla (soft) n02 Eyeshadow by Pralinesims
Jinsoul Lipstick by crypticsim
Clothes -
Love Blossom Earrings by Pralinesims
Ultimate CAS items Unlocker by Loulicorn
Adam Set Ripped Jeans by helgatisha
Alex Sneakers by arethabee
Reverse Reverse Bracelets by AJ Nebula
Shine Bright Dangly Earrings by ghostputty
Aarnes Gown by Rusty's
Olivia Gloves by Sentate
qt headphones v2 by arethabee
Lena Top by arethabee
Booty Bike Shorts by Caio
Extreme Tights by Joliebean
Moonlight Sneakers by Trillyke
Dreams Jumpsuit by Caio
Kitty Choker by Blue Craving
Pentagram Earrings by Blue Craving
K-pop Off Shoulder Dress by HappyLifeSims
Stockings by Sentate
Sakura High Boots by Serenity
Siren Song One Piece Swimsuit by Joliebean
Jessie Dress v2 by arethabee
Clover's Cozy Coat by Nolan-Sims
Woody Jeans by Rusty's
@remussirion @obscurus-sims @squeamishsims @joliebean
@twisted-cat @pralinesims @crypticsim @northernsiberiawinds
@manul-sul-sul @trillyke @nolan-sims @rustys-cc @serenity-cc
@helgatisha @happylifesims @arethabee @caio-cc @sentate
@loulicorn @bluecravingcc
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yoyik456 · 10 months ago
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China supply SERVO VALVE DJSV-001A for turbine generator
China supply SERVO VALVE DJSV-001A for turbine generator Deyang YOYIK skill is strong, the production of strict accordance with national standards. With the power station forging, mining metallurgy, rolling, cement and spare parts spare parts, metallurgy, rolling and other products improve the production and operation system. For hundreds of water technology change, hydropower, thermal power plant overhaul supply of high-quality equipment selection, equipment commissioning, construction plans, spare parts, after-sales service, such as through-train service. The company to undertake hydropower stations, thermal power plant unit capacity transformation, technical transformation and overhaul projects. Look forward to the major manufacturers to inquire. Yoyik can offer many spare parts for power plants as below: #DF-SERVO VALVE DJSV-001A-DF rotary piston pump PVH74QIC-RSM-IS-10-C25-31 pressure hose SMS-15/N1/4-610mm-B EH oil pump PVH131R13AF30B252000002001AB010A oil pump price 50AYZ-63 centrifugal pumps head -50-250C Bladder SB330-50A1/112U-330 rotary vane vacuum pump F3-SV10 vacuum pumps P-1825 centrifugal pump types DFB-100-80-230 bellows Pressure relief valve BXF-40F chemical centrifugal pump YNKN300/200-20Y/J piston pump hydraulic MCY14-1B globe valve FCV6-16V-S-O-NV EH oil main pump 0508.886T1201.AW022 vacuum pump valve spring P-540 COMPLETE O-RING KIT FOR TURNING GEAR 0-0281-0005-00 Solenoid valve 8223G003\220VAC pressure hose S110-AC-FB-0050 mechanical seal for water pump 021-M43K/125-00 centrifugal water pump YCZ65-250B vane pumps F3-SV10 high pressure centrifugal pump DFB125-80-250-03 vacuum pumps P1764-1 mechanical shaft seal LTJ-GJ-125A/R PH Boiler Inlet Damper Motor YEJ2-112M-4 centrifugal pump parts -50-250 variable vane pump F3-V10-IS6S-IC-20 dc screw pump HSNH280-43Z centrifugal pump prices IHF80-50-200 electric motor centrifugal water pump YCZ50-250 switch valve A200C-765000A Electromagnetic servo valve 0508.777T0102.AW016 hydraulic pump station 200LY-67 axial piston variable pump PVH74-Q1C-RSM-1S-11-C25-31 Servo converter SVA9 accumulator bladder NXQ-B-100/2-F-A SERVO VALVE DJSV-001A hydraulic motor 80AY50X10 pressure hose CSH/M20*1.5-1500-A (M16*2/M20*1.5) ac vacuum pump P-537 mechanical seal 45 mm BGM37G/50R-G9 pressure hose S110-AC-FB-0100 dc screw pump ACF080K41RBP piston plunger pump A10VS0100DRS/32R-VPB12N00 vacuum pumps P-1937A piston pump parts PVH74QZC-RSM-1S-1XC25-31 gear oil transfer pump YW-32-160  solenoid valve D1VW020HVZP75XB510 piston plunger pump A10VSO100DR/32R-VPB12N00 vacuum pump ROTARYPUMP NO.30-WS SEARIAL piston pumps PV29 2RID CO2 flexible shaft coupling PVH074R01ABZDV vane vacuum pump F3V201S8S1C11 oil transfer pump 3G70*2-46W piston vacuum pump PVH74RO1A-RSM-1S-10-C25-3 oil pump PVH141R13AF30A230000002001AB01 vane pump working F3-20V12A-1C22 globe check valve (welded) JC80-1.6P twin screw pump NM076SY03S18B axial piston pumps PVH98QICRSE10 mechanical rubber seal BGM37G/60R-G9 burgmann mechanical seal 104G-40 EH oil Circulating coupling F3-V10-1S6S-1C20 bladder NXQB-10/10-L-E vane pumps F3-V10-1S4S-1B20 jacking oil pump outlet non-return valve Aj-ha32bpn31.5mpa needle valve SHV4 25MPa mechanical seal pdf HZB253-H75/110-C115-E1 00 11 solenoid valve DSG-03-3C4-A240-N-50 vacuum oil pump P-2412 Turbine wheel shaft oil thrower YOT51-00-06 piston pump hydraulic PVH098R01AJ30A250000002 pressure hose S100-AC-FB-0320 SERVO VALVE DJSV-001A DFYLSYC-2024-7-8-A
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mikumutual · 5 years ago
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answers aa themed questions nobody asked because i’m cool and sexy
also i havent played the 5th or 6th games so
YOUR FAVOURITE…? 1. Favourite Ace Attorney game? honestly? phoenix wright ace attorney! everything’s fresh, there aren’t many weak characters, and the plot is remarkable (especially the fifth case). the whole trilogy is really good as one unit though 2. Favourite case? 1-4, 1-5, 2-4, and 3-5 are tied lol, i can’t make a decision to save my life. 2-1 is really really funny tho 3. Favourite defendant? as a defendant, lana skye. as a person, edgeworth 4. Favourite prosecutor? as a prosecutor, franziska von karma. as a person, edgeworth 5. Favourite ship? wrightworth obviously... ive probably put more thought into them over the last 3 years than any other ship 6. Favourite victim? probably mia fey or gregory edgeworth... but for non-relevant victims, neil marshall :( 7. Favourite murderer? shelly de killer, i LOVE that guy. but dee vasquez was very cool as well 8. Favourite assistant? maya fey!!!!!!!!!! but i like kay faraday a lot too (im so sorry ema) 9. Favourite witness? adrian andrews... or maybe iris? i mean i didn’t like iris but god what a person 10. Favourite quote? “It doesn't matter how many underhanded tricks a person uses... The truth will always find a way to make itself known. The only thing we can do is to fight with the knowledge we hold and everything we have. Erasing the paradoxes one by one... It's never easy... We claw and scratch for every inch. But we will always eventually reach that one single truth. This I promise you.” - Miles Edgeworth i made this one of my senior quotes :]
YOUR LEAST FAVOURITE…? 11. Least favourite Ace Attorney game? uh fucking apollo justice. literally what the hell was that 12. Least favourite case? turnabout visitor wasn’t very strong? i guess it’s fine as an intro, but it’s also wonky with the timeline of aai 13. Least favourite defendant? max galactica. he’s better in the anime though 14. Least favourite prosecutor? manfred von karma, obviously. i like every other prosecutor (who i know of) though, even winston payne is pretty funny in hindsight 15. Least favourite ship? “miles edgeworth/female oc”. there are a lot of bad ships though, mostly involving phoenix & his assistants. dont do that please 16. Least favourite victim? zak gramarye for kickstarting that shitty, shitty game 17. Least favourite murderer? again mvk... but also fucking frank sahwit LMAO 18. Least favourite assistant? i guess trucy 19. Least favourite witness? fuck everyone from turnabout big top unless it was the anime episode 20. Least favourite memory of Ace Attorney? repeatedly trying and failing to download the emulator for aai2 hbjsjhdb i eventually got it but someone had to send me the download fully pre-patched and i felt kinda useless DO YOU PREFER…? 21. Phoenix Wright or Apollo Justice? phoenix wright. fuck that “GOTCHA!” mechanic jesus christ 22. Maya Fey or Trucy Wright? maya fey. nothing personal against trucy but i just dont like aj hbjsdjhsdb also maya is really sweet and fun and she has the best sprites. she seems like she’d be a good friend, it’s too bad that she doesn’t have the time for them as a spirit medium and all :( if maya ema and kay got to hang out together itd be wild 23. Investigations or trials? trials are easier in my opinion because investigations have several things you could be doing without such a linear style, so if you miss something, you won’t really know until you wander around forever 24. College Phoenix or Hobo Phoenix? college feenie!!!!! he’s like trilogy feenie but more emotional and less witty. i like to pretend that hobo phoenix doesnt exist 25. Klavier Gavin or Kristoph Gavin? who would say kristoph 26. Ace Attorney or Ace Attorney Investigations? ace attorney but only because phoenix is in it lmao. im actually rewatching a playthrough of aai now, and playing aai2 at the same time, so while it is on the mind, i feel like the cases characters and mechanics - while loved - don’t hold up to the OGs 27. Apollo’s perceive, Phoenix’s magatama, or Athena’s Mood Matrix? i actually kinda like the mood matrix more than anything because it has a really good UI and the magatama is kinda grating. but FUCK the gotcha mechanic it is SO FUCKING STUPID and IMPOSSIBLE TO USE.  where is logic chess 28. Ace Attorney trilogy or Apollo Justice and Dual Destinies? you already know my answer to this one 29. 3D models or sprites? i do like the 3d models a lot but i like the original sprites more! imo original pixel sprites > 3D models > HD sprites. mostly bc the hd sprites are garbage (see here, here, and here) 30. Ema Skye as she is in Rise from the Ashes or Ema Skye as she is in Apollo Justice? rfta !!!!!! shes actually really nice as an assistant, esp considering the fact that we actually see her interact with her sister, which is something maya didn’t have very often. also her random appearance in aai was well appreciated by me
MISCELLANEOUS 31. Did you like what they did to Phoenix in Apollo Justice?
NO I AM SO FUCKING MAD WHY WOULD THEY DO THAT TO HIM ISN’T HE A LAWYER WHY COULD HE NOT JUST DEFEND HIMSELF FROM THE FACT THAT HE “FORGED EVIDENCE” IT WASN’T EVEN HIS IN THE FIRST PLACE SOMEBODY ELSE FORGED IT AND HE DIDN’T KNOW THAT, MANFRED VON KARMA GOT AWAY WITH A FUCKLOAD OF NONSENSE AND SO DOES EVERY OTHER LAWYER SO WHY IS IT THAT PHOENIX CAN SURVIVE EATING A POISONED GLASS NECKLACE AND GETTING HIT OVER THE HEAD WITH A FIRE EXTINGUISHER AND FALLING FROM A BURNING BRIDGE INTO A RUSHING RAVINE AND BEING HIT BY A CAR BUT HE CAN’T FUCKING DEFEND HIMSELF LIKE HE DOES IN EVERY OTHER CASE BECAUSE THAT’S THE POINT OF THE GAME AND ALSO HIS ENTIRE CHARACTER
32. Your opinion on Dai Gyakuten Saiban? haven’t played it! it looks pretty cool though
33. Do you think Dai Gyakuten Saiban and/or Miles Edgeworth Investigations 2 will get localised to the West? doubt it, since the creators have said that it won’t be. but the fan translations are pretty good, so i think it’s okay
34. Do you think Miles Edgeworth should get another Investigation-game or do you think another character deserves a spin-off? i mean he already has two, so i guess he doesn’t need another? like i love edgeworth but he’s not as fun without phoenix around. ngl i would play a franziska game. or a maya game, or any spinoff revolving around a side character. hell i’d play hotti game if it meant it took place in the trilogy era
35. Opinion on the soundtrack of the Ace Attorney-franchise? REALLY good. really really good. i love how each game of the trilogy has different composers but each track has the same theme and feel!!!
36. Do you like where the franchise is heading or did you prefer the atmosphere in the original trilogy? seriously absolutely completely prefer the trilogy. i’m sorry but the rush of youth and trust is way, way more enjoyable than whatever “i’m 35 and therefore middle aged” nonsense is happening in the 2020s
37. Capcom suddenly announces that Phoenix will no longer appear in the Ace Attorney franchise! Your reaction? He’s been replaced by Penny Nichols. Fuck you.
38. Capcom suddenly announces that the Ace Attorney franchise has ended for good! Your reaction? it was me i ended it
39. Would you like there to be another Ace Attorney/Professor Layton crossover game? i didnt play it but i really like the idea!!!!!! aa crossover games are really funny to me, i mean have you seen edgeworth in project x zone 2, lmao
40. Would you like an Ace Attorney anime? we have one now! honestly i don’t think it did a very good job of representing the cases, but it did do a good character remix of turnabout big top so that they’re not creepy anymore. they also did a really good job with the anime-specific cases, like the one on the train! it feels a lot better paced when it’s intended for that medium rather than just adapted.  also the childhood episodes made me cry
41. Opinion on anime cutscenes in Ace Attorney? like in 5 and 6? mm, the art style is kinda weird, and i don’t really like the voices, but i guess not everything can be pachinko and prozd
42. Would you want to play an Ace Attorney game where you take on the prosecutor’s role? YEAH ACTUALLY!!!!!! it might be kinda weird being on the right side of the screen though lmao
43. Do you like having DLC in Ace Attorney-games? uhhh i hate having to buy extra things, but i’ll admit that they are pretty funny
44. Opinion on Lamiroir’s storyline? i only played aj so if shes in other games idk but i thought she was fine
45. One thing you think the Ace Attorney games can improve on? stop having creepy characters please. also jesus christ if phoenix and edgeworth arent wearing rings in aa7 i will become the ceo of capcom myself
46. Capcom suddenly announces an Ace Attorney movie! Would you like it to be based on an already existing case or would you like an all new storyline? i mean the musical did a pretty good job of adapting existing cases, so it might as well be new. it would be kinda hard to balance the games’ timeline & character development without being repetitive or an au
47. Capcom suddenly announces an Ace Attorney movie! Would you prefer it being live-action, 3D animated or 2D animated? stylized 2D animation, probably? i would want it to feel more like into the spiderverse than an anime, though. in my dream ace attorney movie, they’d just need a high art budget, several plausible deniability wrightworth scenes, and prozd to voice edgeworth
48. If there could be an Ace Attorney crossover with whatever franchise you’d like, which one would you choose? (Does not need to be a video-game franchise) your turn to die is probably closest in characterization, although its premise is more “locked in a room” than the open-world investigation of aa
49. Opinion on recurring witnesses? (Wendy Oldbag, Lotta Hart, Larry Butz, etc.) honestly, i like them a lot! i don’t know why people hate them so much - i mean, i know lotta lied, and wendy is a horrible old flirt, and larry just kinda sucks all around. but they’re also pretty funny to have around! larry is a constant comic relief who reminds you how much better nick & edgey are in comparison, lotta is likeable as a general character (like in 2-4, although yeah, not remarkable), and wendy oldbag is really funny. she’s so fucking funny. none of you appreciate wendy oldbag’s quirks and you are SLEEPING ON IT!!!!!!!!!!!!
50. Do you think Dual Destinies deserved its M-rating? no idea, holy shit, it got an m-rating? i mean every game before it has had blood violence and very mild swearing, and since DD probably doesnt have anything too sexually risqué, i doubt it deserves a rating any harsher than the rest of the series
okay thanks thats all
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nahodnevegan-blog · 8 years ago
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Poppyseeds soft cakes (Makové linecké koláčiky)
Ingredients:
·         175g butter
·         50g sugar
·         40g sugar powder
·         Vanilla extract
·         220g all purpose flour (plain flour)
·         2 and half Tbsp of poppyseeds
·         Salt
·         Lemon peel
·         Fruit jam
We mix all the ingredients but jam in one bowl. We cover the bowl with foil and leave in the fridge for two hours. When the time is up, we can make cookies out of the dough. We make small circles about 3 mm high. Bake it just for a few minutes because they burn fast so watch it. Bake them till they have this brownish/golden color. After that, let them cool down till they are nice and still. Then take one cookie and put some jam on it an take other cookie and union them together.
Slovak version
Potrebujeme:
·         175g masla
·         50g kryštálového cukru
·         40g práškového cukru
·         1 vanilkový cukor
·         220g hladkej múky
·         2 a pol PL celého maku
·         Štipka soli
·         Citrónová kôra
·         Džem na spájanie
Postup:
Všetky suroviny (okrem džemu) spracujeme na pevné cesto. Zabalíme ho do potravinovej fólie a odložíme na niekoľko hodín do chladničky. Stačia 2 hodinky a cesto môžeme vybrať, rozvaľkať asi na 3mm a vykrajovať tvary podľa vlastnej fantázie. Na dierky v strede sa dajú použiť špajdle, na väčšie slamka. Je však potrebné mať aj plné tvary, bez dierok. Tie poslúžia ako spodné kúsky. Ukladáme na plech vystlaný papierom na pečenie a pečieme pri 180°C veľmi krátko a opatrne pretože koláčiky veľmi rýchlo tmavnú. Po upečení necháme koláčiky vychladnúť a následne  ich spájame džemom.
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zjennings91 · 6 years ago
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Entry 1 - Website
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                                     https://lillardtime.home.blog/
‘Websites have become the most important public communication portal for most, if not all, businesses and organizations’ (Garrett, Chiu, Zhang & Young 2016, p. 1). This is relevant when discussing fan produced tribute websites for athletes, as it can be mutually beneficial for both athlete and website creator.
The athlete benefits from free brand exposure that can reach millions of potential consumers on the internet. In this example, Portland Trailblazers Damian Lillard has a signature shoe deal with Adidas. A fan tribute page that promotes his shoe by virtue of having images of the basketballer and mentioning the shoe line, is free advertising for the All-Star.
Fans of every sport have different habits and routines they partake in to enhance their experience. One of these is socialising with like minded fans (McDonald & Karg 2014). By making a tribute website about their favourite athlete, they set up a forum for these like-minded fans to engage with.
In the case of the NBA, many fans these days won’t support actual franchises. With the amount of player movement in the league, fans will follow their favourite athletes from franchise to franchise. Specific athlete websites give fans a saturation on the specific athlete, instead of balanced content involving other members of the organisation.
Petrovici & Ahmed (2012 p. 4) state that ‘web design itself is a postmodern form of art’. This task instilled the importance of both a websites functionality and aesthetics. To have a successfully marketable website, both of these need to be of a high quality. Also, with the popularity of using smartphones to access websites, compatibility with these devices is a must.
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Garrett, R, Chiu, J, Zhang, L & Young, SD 2016, ‘A Literature Review: Website Design and User Engagement’, Online J Commun Media Technol., vol. 6, no. 3, pp. 1-14, viewed 28 May 2019, Google Scholar
McDonald, H & Karg, AJ 2014, ‘Managing co-creation in professional sports: The antecedents and consequences of ritualized spectator behaviour’, Sport Management Review, vol. 17, no. 3, pp. 292-309, viewed 28 May 2019, ScienceDirect
Petrovici, I & Ahmed, MM 2012, ‘Communication, image and aesthetics in web design: a hermeneutical approach. Case study: aesthetic meanings of black in web design’, Journal of Media Research, vol. 5, no. 2, pp. 3-11, viewed 28 May 2019, ProQuest
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market-researcher · 4 years ago
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Modular Light Panels Market Future Scope, Opportunities with Strategic Growth and Top Players
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The modular light panels market comprises of five segments which are segmented by design into diffused, printed & etched, by shape into square, round & rectangle, by panel widths into 300 mm, 450 mm & 600 mm, by application into domestic and commercial and by distribution channel into online & offline. The market is anticipated to grow at a moderate CAGR over the forecast period, owing to the manufacturers offering customized solutions, thereby leading to reduction in overall costs.
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The manufacturers will not have to maintain bigger stock piles, as these products will be tailor made to suit the requirements of the consumers accordingly which will help keep the unsold inventory at minimal levels. 
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The global modular light panels market is segmented into five major regions comprising of North America, Latin America, Europe, Asia Pacific and Middle East & Africa. The market in Asia Pacific is anticipated to register significant growth, owing to increasing urbanization of the population and huge number of LED light users in the region, who are preferring to own LED lights rather than the traditional fluorescent bulbs.
However, modular light panels market may face some barriers such as the huge presence of unorganized market players who will offer low quality light panels at cheaper prices and the high prices of these products that are not within the reach of the majority of general population that may temporarily limit the growth of the market over the forecast period.
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Green LED Lighting Solutions, Inc., Nanoleaf, Litemax Electronics, Inc., PhotonLab, Tryka L.E.D. Ltd., ArchilumO BV, Daktronics, Inc., SpiffyGear, Westcott, Lifi Labs, Inc. and Ikea Systems B.V.
The outlining enfolds key information of the companies which encompasses business overview, products and services, key financials and recent news and developments. On the whole, the report depicts detailed overview of the global modular light panels market that is expected to help industry consultants, equipment manufacturers, existing players searching for expansion opportunities, new players searching possibilities and other stakeholders to align their market centric strategies according to the ongoing and expected trends in the future.
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ayyoitsalex · 5 years ago
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Chapter 4 - Calling All Collins
-Saturday- The kids and I were up early this morning on account of a special occasion. It's Sam's birthday, so we're taking the weekend to celebrate her. First thing was making Sam's favorite breakfast of chocolate chip waffles with whipped cream. We made everything by hand, and we were serving it to her in bed. The boys also made a card which they both signed, and had Charly put her hand print on. I plated up the food and we all crept upstairs slowly. The boys giggled excitedly walking with the tray of food while I followed behind with Charly. They set the tray on the nightstand next to Sam before standing next to me. I mouthed "1-2-3!" and we all shouted. "Happy birthday mommy!" Sam shot out of bed eyes popping out of her skull. She took a minute to catch her breath before AJ and Cole piled into bed to hug her. "For me!? C'mere my boys!" Sam laughed cuddling the kids. "We made you breakfast mama." Cole smiled proudly pointing. "My favorites. You guys.." She set up the tray in front of her while we all sat up on the bed together taking bites from her. "What about my sweet Charly girl does she want some?" Charly crawled over from the foot of the bed to take a bite. "Mm did mama and brothers do a good job?" Charly just flashed a toothy smile before turning back around to the tv. "Happy birthday love." We shared a small kiss before I smeared a bit of whipped cream on Sam's nose per my family's tradition. She looked at me none too amused but eventually laughed as I kissed it off. -DING DONG- I looked at Sam to see if she knew who would be here this early, but she gave the same look in return. I set Charly next to Sam to investigate downstairs to who was at the door especially so early. When I opened it up I couldn't believe my eyes. "Where is she?" I couldn't even speak I just screamed. Sam bolted up with Charly and the boys to see the commotion. "KAYLA!" Sam shouted running downstairs with Charly. We all hugged while the boys looked at us like we were nuts. "It's been like years!" "I had some time, and your birthday seemed as good an occasion as any to finally stop by and see you guys other than on facetime." "Boys c'mere." They walked over slowly. "This is one of mommy and I's best friends in the world. This is your auntie Kayla." She smiled sweetly at them while they both waved awkwardly in return. "Oh! Honey come on in." Sam and I were both excited for this too, since we'd never met Kayla's daughter in person. She was a spitting image of Kayla and her mom. "This is Kara." She smiled at us waving. She was a little older than Cole, and  in my head I just wanted them to grow up to be best friends. "Hi I'm Kara!" She said extending her hand to Cole. "I'm..Cole." He answered slowly before shaking her hand. "Hey sweetie, why don't you and AJ show Kara the hoop out back to play a little." Kara's eyes lit up as soon as I said hoop. Most definitely Kayla's kid. She couldn't get out there fast enough and before we knew it the kids were laughings and playing. Both Sam and I sat down with Kayla while I held Charly. "So what brings you home?" I asked pouring Kayla a coffee. "Well my overseas season ended and my contract in Seattle wasn't renewed. Just trying to find something to do until someone calls again." "Aw Kay I'm sorry about the Storm." Sam said. "It's okay, I got to be a part of a championship season finally." She showed us her ring and we were both in awe. "Apart from ours that is." "Kara is like an exact copy of you and your mom." Sam said. "Thank god. I'd be kicking myself if she looked like her dad..though I'd still love her regardless." "Things still rough I take it?" I asked pouring everyone a fresh cup of coffee. Kayla nodded hard looking annoyed just thinking about it. "Well atleast you have full custody." "Not like the court had a choice. I'm the only one with a job and a place to live." "So when you're in season overseas where does Kara stay?" "Well we have our place in Seattle and for the most part my overseas seasons are in the summer time. So when I have to leave my sister comes up and stays with her or my parents for the summer. Or I let her go down here to spend the summer. What about you guys? Must have your hands full with three!" "We get by with a lot of help." I laughed. "Yeah both our parents love picking up the kids and letting them stay in the afternoon, and we have no shortage of babysitters to call on." "Right I mean all of your brothers, and Selena's got her siblings. Do either of the boys play ball yet?" Sam and I both shook our heads slightly disappointed. "Mm well maybe later down the line." We both crossed our fingers. "Hey if anything maybe little missy here will play for mommy." Kayla's definitely come a long way with kids from when we first met. Charly reached out for Kayla and she didn't hesitate to hold her. "Well hello! Aren't you sweet. We haven't met before, but your mommies keep sending me pictures." "Augh! My heart just melts looking at them." Sam cuddled close to me. Kayla smirked shaking her head. The kids came back inside catching their breath and sitting down in the living room. "What game over already?" Sam laughed. They all nodded still trying to catch their breath. "Oh! I almost forgot about your present." "Kay you didn't have to get me anything!" "I did so! You two are my best friends, and what kind of friend would I be if I didn't bring gifts for your birthdays." Sam and I looked at one another before shrugging our shoulders in agreement. Kayla handed Sam a bag, to which Sam proceeded to throw around the paper like an animal. Her eyes lit up when she pulled out a frame with her high school jersey and a picture of all of us on our championship night. The boys and Kara gathered around us to look at the photo. It seemed like a lifetime ago, but there we were holding the trophy. "What's on your knee there mama?" AJ asked me. "Mm mommy hurt her knee in the game before this one, and didn't get to play in that game." "Good thing I was there to save the day." Sam laughed hugging me. I rolled my eyes. "Ahem excuse me I was also playing in that game." Kayla leered over at Sam. "So you and mommy were friends even a long time ago huh." AJ said. "A long time ago! Excuse you Adam Justin Ryan, mommy and I aren't that old!" Everyone laughed as Sam huffed.   "Where's that trophy now?" Cole asked. "It's in the gym at school where I coach sweetie. It's in the case next to grandpa's trophy he won when he went to school  there. Maybe someday one of you guys will win one there. Or like auntie Kayla said earlier maybe even Charly girl." Charly flashed a smile at the sound of her name.   Kayla eventually departed to see her family, and we had our own set of people to see for Sam's birthday. All of Sam's brothers were in town for dinner, which meant a rowdy house. Sam and I were just glad it wasn't our house. To be honest I had to have Sam give me a crash course on just exactly who was who since it'd been so long since we'd seen all of her family at one time. I used to think my family was big, but Sam and her brothers take the prize. Five brothers, five sister-in-laws, over ten nephews, and three nieces. If anything I just implore my technique of not using names when talking with someone that remembers me and fake my way through. "HAPPY BIRTHDAY!" Sam's parents house practically erupted from everyone jumping out at us walking through the door. Before we knew it we were getting hugs and kisses left and right from the entire family, and I could tell it was a bit much for the boys. All of Sam's brothers were watching a game in the livng room. "Sammy!" They all rushed her and dog piled on top of her. She managed to squeeze her way out as they turned their attention to me and the boys. A giant group hug enveloped us. I braced myself. "Agh hi guys." I gasped for breath. "Say hi to your uncles boys." I nudged them forward. "Hi uncle, Carson, Scott, Ben, Ronnie, and Darren." Both AJ and Cole made their way over to their cousins in the other room all surrounding a TV and some kind of game system. Sam and I made our way to the rest of the adults to continue our greetings. We all caught up with one another asking the typical questions like how things are going, how's work, etc. A tap on my shoulder and Carson was behind me holding two drinks for Sam and I. We hugged, greeting one another. "So how're the boys? Sam sends me updates every once in a while, but I hate not being so close." "They're good, though we did have an issue like last week. Nothing that couldn't be resolved the old fashioned way. Y'know talking it out, bein-" "You or Sam punched someone didn't you." Carson smirked. "Okay maybe." He shook his head laughing.  I'm closer to Carson more so than any of Sam's brothers cause...y'know he was my last straight relationship . Though you might think that makes things weird, but Carson is happy in his own life with his wife and we're both happy for one another. Carson's wife came over with their little one. "Hey Selena! Oh my god look at Charly lil cutie." Charly flashed a modest grin like yes tell me how cute I am. Carson's kid was just a few months younger than Charly, but by weight you couldn't tell. This was a thicc boi with two c's. We did a typical baby exchange. Avery looked relieved at how light Charly seemed in comparision. "Honey! C'mere check out baby Tommy." Sam's eyes grew big at the sight of the chubby cheeked baby. "Holy fuck lemme see this chonky boy. Yep this ones definitely a Collins alright" It'd been a while since we'd seen Tommy, and when we did he was still newborn. I handed Tommy over to Sam. She started hugging up on him, which didn't please Charly too much who started whining at the sight. Carson, his wife Avery, and myself couldn't help but laugh. "Aw sweetie c'mere it's okay." Carson passed her over to me. She buried her face into my shoulder out of jealousy. "Mommys just giving your cousin some hugs." Charly was having none of it, and just clung onto me for dear life. When it came time for the cake Sam sat alone at the table while we all gathered around to sing. Both the boys stood next to her and we all finished the song clapping as she blew out the candles. As pieces of cake were being handed out to the kids and wives, none of Sam's brothers were to be found. While talking with another of her sisters-in-law I spotted them as they signaled me to keep quiet. I nodded slowly not really knowing what was coming. I pulled out my phone to record, trying to look as innocent a possible. They all snuck up from behind Sam and smashed a cake into her face. I couldn't help but laugh as she started to sprint after all of them. "I AM GOING TO GET ALL OF YOU FUCKERS!" Sam's voiced echoed through her parent's neighborhood. When Sam ran out of gas the boys walked back into the room to see Sam brushing frosting from her face. "You guys are lucky this tastes good.." She growled taking a paper towel to her face. The brothers high-fived me as they walked by me. "Babe! The fuck!" Sam held her arms out demanding an explanation. "Well! They went SHH!" Sam just glared at me while I laughed nervously. "Oh they went SHH. Good one." "I love you?" Sam walked slowly her face still with bits of frosting. I didn't know exactly what was coming, but I just let it happen. She hugged me tight grasping both arms. and smeared her face against mine, getting every possible bit from her face onto mine and my clothes. "Yeah..I deserve this one." Sam nodded furiously. Carson took a picture and posted to his story. Sam looked at me smiling, most of the frosting moved from her face to mine.
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snkrbonbon · 2 years ago
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Nike Air Jordan 1 High MM
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compare-wp10 · 5 years ago
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Focal Cerebral Arteriopathy in a COVID-19 Pediatric Patient | Radiology
See on Scoop.it - COMPARE RISK COMMUNICATION
Summary We present a case of focal cerebral arteriopathy and ischemic stroke in a pediatric COVID-19 patient presenting with seizure, right hemiparesis, and dysarthria with positive for SARS-CoV2 virus both from nasopharyngeal swab and cerebral spinal fluid. Introduction The neuroinvasive mechanism of SARS-CoV-2 is not fully understood. SARS-CoV-2 may enter the central nervous system (CNS) hematogenously, with other proposed routes, including the olfactory and trigeminal nerves, cerebral spinal fluid (CSF), and the lymphatic system (1). Neurologic manifestations in COVID-19 pediatric patients have uncommonly been reported. We report a presumptive case of ischemic stroke due to focal cerebral arteriopathy (FCA) associated with COVID-19. Case Presentation Previously healthy 12 year-old-boy with a new onset of generalized seizures, initially treated with diazepam. Shortly after, he developed right-sided hemiparesis and dysarthria. There was no previous history of fever, cough, shortness of breath, skin rash, hemoglobinopathy, or recent trauma. No one in his family had a known history of COVID-19 infection. The diagnosis of COVID-19 was made by the presence of SARS-CoV2 viral nucleic acid through nasopharyngeal swab using 2019-Novel Coronavirus (2019-nCoV) real-time reverse transcriptase-polymerase chain reaction assay. Testing for the presence of SARS-CoV-2 viral nucleic acid in the CSF was also positive. Viral genome was extracted using a viral RNA kit (Roche®), using a multiplex one-step reverse transcriptase real-Time polymerase chain reaction (PCR), amplifying Covid19 E, N, and ORF1ab/RdRp genes. CSF bacterial culture showed no growth after three days, and tests for herpes simplex virus 1 and 2 and varicella-zoster virus PCR (QIAGEN GmbH, Hilden, Germany) were negative. Serum ferritin measured 86.7 ng/L, C-reactive protein measured 3 mg/L, and erythrocyte sedimentation rate measured 45 mm/h. CSF analysis demonstrated 21 mg/dL of protein, 62 mg/dL of glucose, 100 red blood cells per mm3 (traumatic lumbar puncture), and no white blood cells. CSF opening pressure was 25 mm of H20. D-dimer was not obtained. Platelet count was 285 103/µL, prothrombin time was 12.1, international normalized ratio was 0.9, and partial thromboplastin time was 27 seconds. Antinuclear antibody was normal. Lung low dose computed tomography was normal. Carotid color Doppler ultrasound and echocardiography were normal. Magnetic resonance imaging demonstrated findings consistent with acute infarction without microhemorrhages (Figure 1a, b, and c), along with focal irregular narrowing and banding of the proximal M1 segment of the left middle cerebral artery (MCA) with a slightly reduced distal flow (Figure 1d). High-resolution contrast-enhanced vessel wall imaging was not performed. There were no symptoms of other systems involvement, cervical enlarged lymph nodes, cutaneous or mucosal rash, or redness. The patient had no respiratory abnormalities. The patient received conservative management. Upon discharge, the patient is still hemiparetic at home and undergoing rehabilitation. Discussion The major imaging findings in this patient are the presence of unilateral focal vasculopathy, characterized by focal irregular narrowing and banding of the proximal left middle cerebral artery associated with left basal ganglia and insula acute infarct. There are many potential differential considerations in a child with acute stroke, including FCA, arterial dissection, embolic or thrombotic stroke, cerebral vasculitis in the context of systemic disease (including Kawasaki disease), and genetic disorders with arteriopathy, among others. Our leading diagnosis is FCA, one of the most common causes of childhood arterial ischemic stroke, which is defined by Wintermark et al. (2) as a "unifocal and unilateral stenosis/irregularity of the large intracranial arteries of the anterior circulation (distal internal carotid artery and/or its proximal branches)". Varicella zoster virus vasculopathy is a well-known cause of FCA. Other infectious agents less commonly associated with FCA include other herpesviruses, human immunodeficiency virus, parvovirus B19, influenza A, enteroviruses, and Mycoplasma pneumoniae. Based on the patient’s history and lack of thrombotic processes outside the CNS, embolic stroke, and dissection were considered less likely than FCA. Recent reports of an elevated immune response and an inflammatory syndrome have been reported in children with COVID-19 infection (3). There have been reports of typical vasculitis findings in other organ systems, including Kawasaki disease like presentations (4,5). There was no evidence to suggest a multisystem inflammatory syndrome or Kawasaki-like presentation, as the patient did not show any of the classical clinical physical findings. The lumbar puncture CSF was not inflammatory. To our knowledge Kawasaki-like illnesses do not manifest as FCA. The presence of SARS-CoV-2 material from the nasopharynx swab is evidence that the patient had COVID-19, and the presence of the virus in the CSF, although uncommon, further corroborates CNS involvement. * S.M.M.M. and F.G.G. contributed equally to this article. Bibliography 1. Li Z, Liu T, Yang N, Han D, Mi X, Li Y et al. Neurological manifestations of patients with COVID-19: potential routes of SARS-CoV-2 neuroinvasion from the periphery to the brain. Front. Med. 2020 May 4; Crossref, Google Scholar 2. Wintermark M, Hills NK, DeVeber GA, Barkovich AJ, Bernard TJ, Friedman NR et al. Clinical and Imaging Characteristics of Arteriopathy Subtypes in Children with Arterial Ischemic Stroke: Results of the VIPS Study. AJNR Am J Neuroradiol. 2017 Nov;38(11):2172–9. Crossref, Medline, Google Scholar 3. Mahase E. Covid-19: concerns grow over inflammatory syndrome emerging in children. BMJ. 2020 Apr 28;369:m1710. Google Scholar 4. Castelnovo L, Capelli F, Tamburello A, Maria Faggioli P, Mazzone A. Symmetric cutaneous vasculitis in COVID-19 pneumonia. J. Eur. Acad. Dermatol. Venereol. 2020 May 7; Crossref, Medline, Google Scholar 5. Viner RM, Whittaker E. Kawasaki-like disease: emerging complication during the COVID-19 pandemic. Lancet. 2020 May; Crossref, Google Scholar
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anoasisofhealing · 6 years ago
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Estrogen Metabolism Pathway And The 3 Primary Estrogen Metabolites
Estrogen metabolism pathway: there are three pathways and I label them as the good, bad, and ugly.
Previously, I mentioned the 3 primary estrogens: estradiol, estrone, and estriol. That is the simple. The complex is that there are many more estrogens that are actually produced by the body through the process of estrogen metabolism—estrogen metabolites.
Estrogen metabolites have been shown to have different effects on cancer risk. This difference in risk is the result of an interplay between an individuals genetics and their environment. The vast majority of the research on estrogen metabolism is with cancer. The majority of the research on estrogen metabolism with cancer is with breast cancer.
When it comes to estrogen metabolism and cancer there are 3 primary estrogen metabolism pathways to highlight.  I call them the good, the bad and the ugly. There are 3 primary estrogen metabolites from these 3 pathways: 2-hydroxy estrone (2OH-estrone), 4-hydroxy estrone (4OH-estrone), and 16alpha-hydroxy estrone (16alphaOH-estrone).
The origin estrogens for these 3 metabolites are primarily Estradiol (the most potent estrogen) and Estrone (the second most potent estrogen). Estriol, the weakest estrogen, can be converted to the 16alpha-OH-estrone metabolite, but not to the 2OH-estrone or 4OH-estrone metabolites. Additional estrogen metabolites include:
2-OH Estradiol
4-OH Estradiol
16alpha-OH Estradiol
2-methoxy Estrone
2-methoxy Estradiol
16-epi Estriol
17-epi Estriol
16-keto Estradiol
For the purpose of the brevity of this blog post, I will stick to a brief discussion of these 3 primary estrogen metabolites.
Dr. Nathan Goodyear Explains The 3 Primary Estrogen Metabolism Pathways
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2OH-Estrone Metabolite
The 2OH-estrone metabolite is the safest estrogen metabolite.  The better descriptive term to describe the 2OH-estrone metabolite is “safest” or “lowest risk” and that may too be overly simplistic. The 2OH-estrone metabolite is the most prevalent estrogen metabolite circulating in the blood [63].
Research points to the 2OH-estrone metabolite as the byproduct of the CYP1A1, CYP1A2, and CYP1B1 detoxification enzymes [64] [65] though studies do suggest that CYP1A1 is the primary enzyme involved in the production of the 2OH-estrone metabolite [66] [67] [68]. This “good” term for the 2OH-estrone metabolite is also an oversimplification of the scientific evidence on this estrogen metabolite as some more recent evidence points to an increased breast cancer risk with the 2-hydroxyestrone metabolite.
There are several mechanisms that support 2OH-estrone metabolite as the safest estrogen metabolite.  First, all of the estrogen metabolites are particularly unstable compounds.  The 2OH-estrone metabolite is the most stable of the 3 estrogen metabolites discussed [69] which translates to less potential DNA damage.
It is DNA damage that is critical in carcinogenesis. Second, the 2OH-estrone metabolite elicits a very weak, almost anti-estrogenic activity [70] [71].  Low binding affinity for the estrogen receptor and increased removal from the estrogen receptor are the primary reasons for the weak estrogenic activity of the 2OH-estrone metabolite. This estrogenic activity is the weakest of the 3 estrogen metabolites.
Third, though weak as indicated above, the 2OH-estrone metabolite is easily methylated and thus inactivated. Last, the 2OH-estrone metabolite lacks significant anti-apoptosis activity [72] which maintains a strong anti-growth potential check through the active process of apoptosis (programmed cell death).
4OH-Estrone Metabolite
The bad estrogen or what I call the “ugly” estrogen metabolite is the 4OH-estrone metabolite.  The overwhelming evidence points to the 4OH-estrone metabolite as pro-carcinogenic and pro-growth.
There are several reasons why the 4OH-estrone metabolite is the most dangerous estrogen metabolite. First, the 4OH-estrone metabolite is the most unstable of the estrogen metabolites and it is this instability that can lead to DNA damage which is important in carcinogenesis. Second, of the 3 metabolites, the 4OH-estrone metabolite elicits the strongest estrogenic activity via its high affinity and tight binding to the estrogen receptor and lower disassociation rate from the estrogen receptor.
Third, in contrast to the 2OH-estrone metabolite, the 4OH-estrone metabolite is not easily deactivated through methylation. Last, the 4OH-estrone metabolite has a significant anti-apoptotic effect which favors such cancer cell survival.   All this at an estimated 15-25% less circulating volume than the 2OH-estrone metabolite.
16alphaOH-Estrone Metabolite
The 16alphaOH-estrone metabolite has been historically labeled as a “bad” estrogen. This pathway of estrogen metabolism, as a whole, is the dominant pathway of estrogen metabolism 16.  The proposed high cancer risk of the 16alphaOH-estrone metabolite is due to its increased estrogen signaling and growth capacity through its tight binding to the estrogen receptor.  In addition, it is not easily removed leaving the metabolite tightly bound to the estrogen receptor resulting in a prolonged growth signal.
In addition, the 16alphaOH-estrone metabolite does not down-regulate the estrogen receptor, which is a key mechanism by which cells can turn down the potential signal. Finally, 16alphaOH-estrone metabolite has a strong anti-apoptotic effect [73]. The jury is out on the “bad” label for this metabolite. The 16alpha-OH-estrone metabolite has a strong positive link to breast cancer in post-menopause women [74] yet, other studies have found no link between 16alpha-OH-estrone and cancer risk [75] [76].
The implication is that it may not only be the estrogen levels or the estrogen receptors that are involved in cancer risk, but it is, in fact, what the body is doing with the estrogens through estrogen metabolism that also poises the cancer risk.
[63] Adlercreutz H, Fotsis T, Hockerstedt K, Hamalainen E, Bannwart C, Bloigu S, Valtonen A & Ollus A 1989 Diet and urinary estrogen profile in premenopausal omnivorous and vegetarian women and premenopausal women with breast cancer. Journal of Steroid Biochemistry and Molecular Biology 34 527–530.
[64] Cribb AE et al.  Role of polymorphic human cytochrome P450 enzymes in estrone oxidation. Cancer Epidemiol Biomarkers Prev. 2006 Mar. 15/551.
[65] Sowers MR et al. CYP1A1 and CYP1B1 polymorphism and their association with estradiol and estrogen metabolites in women who are premenopausal and perimenopausal. Am J Med. Sep 2006;119(9 Suppl 1): S44-51.
[66] Lee AJ, Cai MX, Thomas PE, Conney AH, Zhu BT. Characterization of the oxidative metabolites of 17β-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology 2003;144:3382–98.
[67] Shimada T, Watanabe J, Kawajiri K, et al. Catalytic properties of polymorphic human cytochrome P450 1B1 variants. Carcinogenesis 1999;20:1607–13.
[68] Kisselev P, Schunck WH, Roots I, Schwarz D. Association of CYP1A1 polymorphisms with differential metabolic activation of 17β-estradiol and estrone. Cancer Res 2005;65:2972–8.
[69] Bradlow HL, Telang NT, Sepkovic DW, Osborne MP. 2-Hydroxyestrone: the ‘good’ estrogen. J Endocrinol 1996;150 Suppl:S259–65.
[70] Schneider J, Huh MM, Bradlow HL, Fishman J. Antiestrogen action of 2-hydroxy estrone on MCF-7 human breast cancer cells. J Biol Chem. 1984;259:4840–5.
[71] Vandewalle B, Lefebvre J. Opposite effects of estrogen and catechol estrogen on hormone-sensitive breast cancer cell growth and differentiation. Mol Cell Endocrinol. 1989;61:239–46.
[72] Seeger H, Wallwiener D, Kraemer E, Mueck AO. Comparison of possible carcinogenic estradiol metabolites: effects on proliferation, apoptosis, and metastasis of human breast cancer cells. Maturitas 2006;54:72–7.
[73] Seeger H et al.  Comparison of possible carcinogenic estradiol metabolites: effects on proliferation, apoptosis, and metastasis of human breast cancer cells. Maturitas. 2006 Apr;54(1):72-7.
[74] Kabat GC, Chang CJ, Sparano JA, et al. Urinary estrogen metabolites and breast cancer: a case-control study. Cancer Epidemiol Biomarkers Prev. 1997;6(7):505-509.
[75] Mackey RH et al. Hormone therapy, estrogen metabolism and risk of breast cancer in the Women’s Health Initiative. Cancer Epidemiol Biomarkers Prev. 2012 Nov;21(11):2022-2032.
[76] Arslan AA et al. Circulating estrogen metabolites and risk for breast cancer in premenopausal women. Cancer Epidemiol Biomarkers Prev. 2009 Aug;18(8):2273-9.
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tumimmtxpapers · 8 years ago
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Ex vivo expanded natural killer cells from breast cancer patients and healthy donors are highly cytotoxic against breast cancer cell lines and patient-derived tumours.
Ex vivo expanded natural killer cells from breast cancer patients and healthy donors are highly cytotoxic against breast cancer cell lines and patient-derived tumours. Breast Cancer Res. 2017 Jul 01;19(1):76 Authors: Shenouda MM, Gillgrass A, Nham T, Hogg R, Lee AJ, Chew MV, Shafaei M, Aarts C, Lee DA, Hassell J, Bane A, Dhesy-Thind S, Ashkar AA Abstract BACKGROUND: Natural killer (NK) cells play a critical role in cancer immunosurveillance. Recent developments in NK cell ex-vivo expansion makes it possible to generate millions of activated NK cells from a small volume of peripheral blood. We tested the functionality of ex vivo expanded NK cells in vitro against breast cancer cell lines and in vivo using a xenograft mouse model. The study aim was to assess functionality and phenotype of expanded NK cells from breast cancer patients against breast cancer cell lines and autologous primary tumours. METHODS: We used a well-established NK cell co-culture system to expand NK cells ex vivo from healthy donors and breast cancer patients and examined their surface marker expression. Moreover, we tested the ability of expanded NK cells to lyse the triple negative breast cancer and HER2-positive breast cancer cell lines MDA-MB-231 and MDA-MB-453, respectively. We also tested their ability to prevent tumour growth in vivo using a xenograft mouse model. Finally, we tested the cytotoxicity of expanded NK cells against autologous and allogeneic primary breast cancer tumours in vitro. RESULTS: After 3 weeks of culture we observed over 1000-fold expansion of NK cells isolated from either breast cancer patients or healthy donors. We also showed that the phenotype of expanded NK cells is comparable between those from healthy donors and cancer patients. Moreover, our results confirm the ability of ex vivo expanded NK cells to lyse tumour cell lines in vitro. While the cell lines examined had differential sensitivity to NK cell killing we found this was correlated with level of major histocompatibility complex (MHC) class I expression. In our in vivo model, NK cells prevented tumour establishment and growth in immunocompromised mice. Finally, we showed that NK cells expanded from the peripheral blood of breast cancer patients show high cytotoxicity against allogeneic and autologous patient-derived tumour cells in vitro. CONCLUSION: NK cells from breast cancer patients can be expanded similarly to those from healthy donors, have a high cytotoxic ability against breast cancer cell lines and patient-derived tumour cells, and can be compatible with current cancer treatments to restore NK cell function in cancer patients. PMID: 28668076 [PubMed - in process] http://dlvr.it/PRrzLh
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ytechsk-blog · 8 years ago
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Spoločnosť Samsung dnes na veľtrhu MWC (Mobile World Congress) predstavila Samsung Galaxy Tab S3 a Samsung Galaxy Book. Tablety vyznačujúce sa štýlovým dizajnom s pokročilou technológiou ponúkajú prémiový mobilný zážitok. Galaxy Tab S3 umožňuje širokú škálu využitia, prináša skvelé video a je zárukou kvalitných herných zážitkov. Galaxy Book je určený profesionálom, ktorí sa môžu tešiť na vyšší výkon pre prácu i zábavu.
Galaxy Tab S3 disponuje 9,7″ Super AMOLED displejom. Model Galaxy Book 10,6″ je vybavený TFT LCD displejom a 12″ verzia ponúka Super AMOLED displej.
HDR (High Dynamic Range) video obsah: Galaxy Tab S3 a 12″ Galaxy Book podporujú prehrávanie videa v HDR (10bit farebné video) pre skutočné farby a živý digitálny obsah.
Samsung Flow: Ide o technológiu pre ľahšiu prácu, ak už ste kdekoľvek. Pre bezpečný prístup k dátam využíva Samsung Flow prihlásenie prostredníctvom biometrických znakov, bezdrôtovo prepojí kompatibilné zariadenia a užívateľ tak môže zdieľať a odosielať dokumenty z mobilného zariadenia do tabletu. Zároveň synchronizuje upozornenia na správy, aby používatelia nezmeškali žiadnu dôležitú komunikáciu, či už práve využívajú svoj smartfón, alebo tablet.
S Pen: Nová verzia praktického pera S Pen má menšiu špičku (0,7 mm) a zároveň vyššiu citlivosť na tlak, aby jeho používanie bolo ešte prirodzenejšie. S perom je možné využívať aj ďalšie pohodlné funkcie ako sú Screen Off Memo pre rýchle zapisovanie poznámok, PDF Annotation pre jednoduchú editáciu, alebo prostredníctvom nástroja Advanced Drawing kreslenie na profesionálnej úrovni.
Oba tablety prinášajú 13 Mpix zadný fotoaparát s automatickým zaostrovaním a 5 Mpix predného fotoaparátu pre zhotovovanie vysoko kvalitných snímok. Tablety umožňujú rozšírenie pamäte prostredníctvom pamäťových kariet a prinášajú vyššiu energetickú účinnosť aj možnosť rýchleho nabíjania. Prehrávať video na Galaxy Tab S3 je možné až 12 hodín, na 12″ modeli Samsung Book až 10,5 hodín. Oba tablety tiež podporujú Pogo klávesnice, ktoré nie je nutné párovať alebo samostatne dobíjať.
„V Samsungu sa neustále snažíme posúvať hranice možností našich mobilných zariadení a zákazníkom ponúkať produkty tej najvyššej kvality, ktoré napĺňajú ich potreby a očakávania,“ povedal DJ Koh, prezident divízie mobilných komunikácií spoločnosti Samsung Electronics. „Nové modely tabletov sú vybavené tou najmodernejšou technológiou, ktorá užívateľom umožňuje všestranné využitie doma, v kancelárii aj na cestách“
Samsung Galaxy Tab S3: optimalizovaný pre zábavu i všestranné využitie
Samsung Galaxy Tab S3 posúva latku vizuálnych zážitkov. Obraz ako v kine si užívatelia môžu vychutnať vďaka prehrávaniu videí v kvalite 4K na vynikajúcom displeji Super AMOLED. Zároveň je Galaxy Tab S3 vybavený štyrmi stereo reproduktormi vyladenými od spoločnosti AKG by HARMAN, ktoré sú zárukou jedinečnej kvality zvuku. Široká ponuka HDR obsahu je kedykoľvek k dispozícii napríklad prostredníctvom služby od Amazonu.
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Herné zážitky posúva do novej dimenzie Vulkan API zaisťujúci úžasnú grafiku a Game Launcher, ktorý poskytne rozšírené užívateľské rozhranie a personalizovaný prístup vrátane módu „Do Not Disturb“, ktorý je zárukou ničím nerušenej zábavy.
Vďaka inovovanému peru S Pen sú užívatelia Galaxy Tab S3 produktívnejší, tvorivejší a zvládnu viac vecí naraz. S Galaxy Tab S3 sú užívatelia vždy pripojení vďaka rýchlemu nabíjaniu a dlhej výdrži batérie.
Samsung Galaxy Book: Vyšší výkon a výdrž, dizajn 2 v 1
Samsung Galaxy Book je dostupný vo variantoch 10,6″ a 12″. Oba modely vychádza v ústrety profesionálom, ktorí trávia väčšinu času na cestách a vyhľadávajú výkonné mobilné zariadenia. Samsung Galaxy Book je ľahký a všestranný a jednoducho ho možno premeniť z tabletu na notebook.
Aby mohol tablet poskytovať výkon skutočne profesionálnej úrovne, je 12″ model Samsung Galaxy Book vybavený 7. generáciou Intel Core i5 procesora, Dual Core 3,1 GHz, a 10,6″ model je vybavený procesorom Intel Core m3, Dual core 2,6 GHz.
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Galaxy Book je postavený na operačnom systéme Windows 10 a užívateľom ponúka plnú verziu balíka Microsoft Office. Zároveň dáva k dispozícii širšiu klávesnicu s lepšie rozpoznateľnými klávesmi, takže je s ňou možné pohodlne písať rovnako ako na tradičnom PC.
Samsung Galaxy Tab S3 a Samsung Galaxy Book (10,6” a 12”) – produktové špecifikácie
Samsung Galaxy Tab S3 Samsung Galaxy Book 10,6” Samsung Galaxy Book 12”   Displej 9,7” Super AMOLED QXGA (2048×1536) 10,6″ TFT FHD (1920×1280) 12″ Super AMOLED FHD (2160×1440)   Chipset Qualcomm® Snapdragon™ 820
Quad Core 2,15GHz + 1,6 GHz
7. generácia Intel® Core™ m3 procesor,
Dual Core 2,6 GHz
7. generácia Intel® Core™ i5 procesor
Dual Core 3,1 GHz
  LTE podpora LTE kategórie 6 (300 Mbps) LTE kategórie .6 (300 Mbps) LTE kategórie .6 (300 Mbps) Pamäť 4 GB + 32 GB
microSD až do 256 GB
4 GB + 64 GB/128 GB eMMC
microSD až do 256 GB
4 GB + 128 GB SSD / 8 GB + 256 GB SSD
microSD až do 256 GB
  Fotoaparát 13 MP AF + 5,0 MP, blesk 5 MP FF 13 MP AF + 5 MP   Port USB 3,1 (Typ C) USB 3,1 (Typ C), MicroSD USB 3,1 (Typ C) x 2 porty, MicroSD   Senzory Akcelerometer, Hallov senzor, RGB senzor, Senzor odtlačkov prstov, Gyroskopický senzor, Geometrický senzor Akcelerometer, Hallov senzor, Svetlo Akcelerometer, Hallov senzor, Svetlo   Konektivita Wi-Fi 802.11 a/b/g/n/ac, 2X2 MIMO, Wi-Fi Direct, Bluetooth® 4.2 Wi-Fi 802.11 a/b/g/n/ac, 2X2 MIMO, Bluetooth® 4.1 BLE Wi-Fi 802.11 a/b/g/n/ac, 2X2 MIMO, Bluetooth® 4.1 BLE   GPS GPS, GLONASS, BEIDOU, GALILEO GPS, GLONASS GPS, GLONASS   Rozmery, váha 237,3 x 169,0 x 6,0mm 429 g (Wi-Fi) / 434 g (LTE) 261,2 x 179,1 x 8,9 mm, 640 g (Wi-Fi) / 650 g (LTE) 291,3 x 199,8 x 7,4 mm, 754 g (Wi-Fi / LTE) Batéria 6 000 mAh, Rýchlonabíjanie 30,4 W / až 10 hod, Rýchlonabíjanie 39,04 W / až 10,5 hod, Rýchlonabíjanie   Operačný systém / upgrade Android 7.0 Windows 10 Windows 10   Samsung služby a aplikácie Samsung Smart Switch, Samsung Notes, Air Command, Samsung Flow Samsung Notes, Air Command, Samsung Flow Samsung Notes, Air Command, Samsung Flow   Video Nahrávanie: 4K (3840 x 2160) @ 30 fps
Prehrávanie: 4K (3840 x 2160) @ 60 fps
Nahrávanie: FHD(1920 x 1080) @ 30fps
Prehrávanie: 4K (3840 x 2160) @30 fps
Nahrávanie: FHD (1920 x 1080) @30fps
Prehrávanie: 4K (3840 x 2160) @60fps
    * Všetky funkcie, vlastnosti, špecifikácie a ďalšie informácie o produkte uvedené v tomto dokumente, vrátane, ale nie výhradne, výhod, dizajnu, ceny, komponentov, výkonu, dostupnosti a vlastností výrobkov môžu byť zmenené bez predchádzajúceho upozornenia.
** MicroSD pamäťové karty sú predávané samostatne.
    Samsung Tab S3 a Galaxy Book: štýlové a profesionálne Spoločnosť Samsung dnes na veľtrhu MWC (Mobile World Congress) predstavila Samsung Galaxy Tab S3 a Samsung Galaxy Book.
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