#B-Cell

[dr-afsaeed]

Antigen Presenting Cells

Antigen Presenting Cells Antigen-presenting cells (APCs) play a crucial role in the immune system, bridging innate and adaptive immunity. They are responsible for capturing, processing, and presenting antigens to T cells, thus enabling the body to recognize and respond to pathogens, cancerous cells, and other foreign substances. The primary professional APCs are dendritic cells, macrophages, and…

[hinamie]

quick megumi style study

[reasonsforhope]

"Two researchers in the US and Australia have discovered important mechanisms that prevent B cells from attacking the body’s own tissues in autoimmune diseases like arthritis, lupus, and multiple sclerosis—and in the process have won a prestigious prize.

Normally, the body’s immune system protects us from viruses, bacteria, and foreign substances. However, in autoimmune diseases, the immune system starts attacking tissues in the body instead.

Researchers had long tried to discover the cause of autoimmune diseases. But, Christopher Goodnow and David Nemazee, independently of each other, adopted a new approach.

They asked why we do not all develop these diseases. Their focus was on B cells which, together with white blood cells and T cells, are the building blocks of our complex immune system.

“They have given us a new and detailed understanding of the mechanisms that normally prevent faulty B cells from attacking tissues in the body, explaining why most of us are not affected by autoimmune diseases,” says Olle Kämpe, member of the Royal Swedish Academy of Sciences and chair of the Crafoord Prize committee that awarded the pair 6 million Swedish kronor ($600,000).

Neutralize B cells

In recent years, physicians have started to experiment by using existing drugs to neutralize B cells for patients with severe autoimmune diseases, including lupus, rheumatoid arthritis, and multiple sclerosis, which has proven to be very effective at improving their quality of life.

Thanks to this year’s Crafoord Prize Laureates, we have gained fundamental new knowledge about what is happening in the immune system during autoimmune disease attacks.

“This also paves the way for development of new forms of therapies that eventually can cure these diseases—or might prevent them in the future,” said one professor of clinical immunology at the Royal Swedish Academy of Sciences...

More details from the video, since the article glosses over the particulars:

"The laureates discovered what is now called B cell tolerance.

When B cells develop in the bone marrow, not all of them are perfect. To remove the faulty ones, a mechanism starts, in which defective cells are programmed to destroy themself through apoptosis.

The laureates discovered two new mechanisms that are used if some of the bad cells are left. Re-editing, where the immune system alters the combination of receptors, and anergy, that silences B cells with self-reactive receptors.

The laureates were able to demonstrate that these mechanisms sometimes fail. This means that faulty B cells can cause an attack on the body's own tissues – leading to autoimmune diseases.

Thanks to the laureate’s discoveries, doctors like Anders Bengtsson soon felt able to start treating patients with lupus, arthritis, multiple sclerosis, and many other autoimmune diseases, with medicines that eradicated B cells.

Anders Bengtsson: "I'm very happy that B cells has gotten so much attention because of the laureates. I have seen my patients getting so much better and getting a better life."

Autoimmune patient: "Today, I feel very good. I really have hope in the research that it will revolutionise things and perhaps even cure it all. That’s what I want, hope for, and believe in.""

-Article via Good News Network, April 6, 2025. Video via The Royal Swedish Academy of Sciences, January 29, 2025.

[zzbubblegumbitchzz]

Can we PLS have Quinn Hughes prompt “you ruined me.” Smut or fluff you decide!!

i’m weak for this prompt tbh and i’m so sorry for the delay man

Quinn Hughes - fluff prompt 1 - “you ruined me.”

CW: fluff. fluff. fluff

Hockey has always been the most important thing in his life. Living, breathing. All of it focused around hockey. His parents, his brothers. Hockey, hockey, hockey. Then Quinn met you and everything changed. It was hockey, hockey and you.

It was hard, his brain didn’t know what to do and he was scared. He was so fucking scared. What if he was a bad partner? What if he made you feel second? What if he accidentally neglected you?

He wouldn’t be able to live with himself if he hurt you.

You were the sunshine to him. No matter the outcome of anything, he looked to you. His person. His girl.

His happiness wasn’t centered around what outcome of the game was anymore. Truthfully? It hasn’t been since you said yes to coffee his 2nd year in Vancouver.

Now, Quinn sat on his overly expensive couch with you tucked under his arm. Soft snores that you’d deny even happening, but he loved. Cause he knows you only snore when he’s around. Something that tells him, you feel most comfortable with him.

His hands found their home in your hair. His voice barely above a whisper.

“You are perfect. Everyone joked around that the sport was the love of my life and I believed them. Then you came around, and you ruined me. I could retire right now and never look back, cause I'd still have you. I swear to god honey, I'm gonna put a ring on your finger. You’re never leaving me, I'm never leaving you. You’re it. Nothing else matters, me and you.”

Just as he laid his head back, your voice spoke.

“I love you, Quinny.”

[shaunashipmn]

OUTER BANKS ⇢ 3x08 | TAPPING THE RUDDER

[meowguiiiin]

てれぱし

I want to animate but I lose motivation quickly so I never finish,,,

[catwyk]

thinkin abt mercer and gage again

[bamburh]

What u doin?

[joelywoely]

WATCHRD THIS SHOW. LOVED IT. also my rare pair bcell x memory cell. I LOVE HOW SUPPORTIVE RED AND WHITE ARE OF EACH OTHER I NEED THEM TO KISS NOOOWWWWW.

[vaguely-concerned]

just for fun this time during 'sea of blood' I counted out all the venatori corpses I think we can be pretty sure were lucanis' handiwork before we show up (not including the ones he kills in his initial cutscene, and with an assumption that he's been at work mainly up and down in the areas we move through until we find him, not behind the locked door -- I think that's mostly the work of rampaging undead and other venatori-hoisted-by-their-own-petard suchlikes). can thus happily inform you lucanis has killed at least 32 venatori before rook and company get there. at least one of them he's impaled on their own weird crystal spike things the venatori mages cast as an AOE attack and that they're trying to keep him contained with when we find him. so he's clearly been keeping busy lol. that's my boy dispensing poetic justice and claiming some enrichment in his enclosure while he's at it good for him!

[the-alien-incident]

Bow down... bow down... before the power of Santa!

Glamour shots under the cut:

[not-that-debonair]

video editor failed me but I needed you all to see my vision

Versions without text under the cut

[this-world-of-beautiful-monsters]

b&g really the book of all time because you've got this guy who spends the whole entire book talking about the glory of Rome and the barbarity of non-Romans and how he only likes places that remind of Rome, then he takes in this young Slavic boy and treats him as an exotic other and dresses him in a color that Romans associate with barbarians and constantly fret about the boy being too attached to his home family and culture and then when the Slavic boy gets kidnapped and brainwashed and tortured there's a choice that's offered between saving him and between going after this powerful, beautiful Roman woman Marius has been obsessed over all book, who is thousands of years old and according to Supernatural M16 has to be saved from her evil Indian lover. and of course Marius is going to go after the Roman woman instead of the Slavic boy, regardless of other factors like Akasha's influence or whatever, of course he's got been building this entire racialized structure in his head about who deserves saving and who does not that operates here. of course.

[psygull-arts]

SCRATCH MARKS LEFT ACROSS THE SURFACE OF YOUR MIND

guy who almost got killed by mothman TWICE. he's fine. he's not having panic attacks at stoplights. he doesn't see those burning eyes when he closes his own. he's doing good

[moved-blogs13]

older CaW art I forgot to post… (around 3 months ago 😭)

[helloiamadrawer]

Finally had time to make this meme :)