#BioDiscovery

[mikyit]

https://lnkd.in/dChxaebB Successful approaches for #Personalised #Medicine 👩‍⚕️👦 are becoming a reality. ---- The best practice examples cover different aspects of the #ValueChain ⛓️‍, in particular, two different types: - - 💥 1. Successful translation of #Personalised #Medicine #research 🔬 into an added value for the #patient 😷. - - 💥 2. #Policy making and impact #analysis 📊 for #Personalised #Medicine #research.

_-_-_ Here are the selected examples, click here (https://lnkd.in/dChxaebB) from more :

🚀 - Mosaic Initiative: a Launchpad for Personalised Medicine - Israel

🚀 - Implementation of Personalised Medicine - Estonia

🚀 - The Ubiquitous Pharmacogenomics (U-PGx) Education Programme - EU

🚀 - Centers for Personalized Medicine (ZPM) - Germany

🚀 - Swiss Personalized Health Network (SPHN) - Switzerland

🚀 - Translational medicine in Familial hypercholesterolaemia - Portugal

🚀 - The “HAZLO” project - Spain

🚀 - MedeA – Pharmacogenetics Personlised Prescription - Spain

🚀 - Strimvelis® Gene Therapy - Italy

🚀 - PERSEPHONE project - Italy

🚀 - MASTER – Innovation Driver for Personalised Oncology - Germany

🚀 - Electronic medical records (EMR) for personalised treatment - Italy

🚀 - 2025 France Genomic Medicine Initiative - France

🚀 - Genomic Medicine Sweden - Sweden

🚀 - Pharmacogenetic Recommendations for PM - Estonia

🚀 - Navarra 1,000 Genomes Project - Spain

🚀 - Network Genomic Medicine (NGM) Lung Cancer - Germany

[magazinesubscriptions11]

𝐁𝐢𝐨𝐥𝐨𝐠𝐲 𝐓𝐨𝐝𝐚𝐲 𝐌𝐚𝐠𝐚𝐳𝐢𝐧𝐞 𝐒𝐮𝐛𝐬𝐜𝐫𝐢𝐩𝐭𝐢𝐨𝐧𝐬 𝐎𝐧𝐥𝐢𝐧𝐞 𝐢𝐧 𝐈𝐧𝐝𝐢𝐚

Biology Today magazine is your ultimate source for education and competition in the world of biology. With its comprehensive content and thrilling opportunities, this magazine has become a trusted companion for biology enthusiasts, students, and professionals. 

[bpod-bpod]

Nuclear Leukaemia

The most common genetic fault found associated with the blood cancer acute myeloid leukaemia is a nucleophosmin gene NPM1 mutation. Normal NPM1 activity maintains structures of the cell nucleus called nucleoli, but in NPM1-mutated AML nucleoli are distorted and malfunction, faults which are potential therapeutic targets

Read the published research article here

Image from work by Martin Grundy and colleagues

Translational Medical Sciences, Biodiscovery Institute, University of Nottingham, Nottingham, UK

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Journal of Cell Science, May 2025

You can also follow BPoD on Instagram, Twitter, Facebook and Bluesky

[darkmaga-returns]

By Frank Bergman May 15, 202

A group of world-renowned American doctors and scientists has issued a warning after alarming new data emerged revealing “molecular chaos” in people who received Covid mRNA “vaccines.”

The warning was issued during a new interview featuring bioscientist Dr. John Catanzaro, cardiologist Dr. Peter McCullough, and epidemiologist Nicolas Hulscher, MPH.

During this groundbreaking discussion, the leading experts present new molecular data on patients impacted by Covid mRNA “vaccination.”

The data was uncovered during a joint investigation by Catanzaro’s Neo7Bioscience and the University of North Texas Genomics & Biodiscovery Institute.

The alarming findings of the study have exposed a concerning pattern of biological disruption.

The investigation utilized the RNA Expression Variant Instability Signature Surveillance (REViSS) platform.

[jobrxiv]

Research Associate/Fellow (Leukaemia, Molecular Biology) University of Nottingham Postdoc available in Nottingham, studying the molecular basis of RUNX1-driven Acute Myeloid Leukaemia, let's improve survival now! See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-nottingham-27778-research-associate-fellow-leukaemia-molecular-biology/?feed_id=68688 #Cancer_Genomics #cell_culture #crispr #Haematology #molecular_biology #ScienceJobs #hiring #research

[biglisbonnews]

Scientists are racing to explore more of the ocean hoping to discover medical breakthroughs and address the climate crisis An array of organizations are working to scale marine biodiscovery to discover beneficial traits from plants, animals, and microorganisms. https://www.businessinsider.com/marine-biodiscovery-could-unlock-answers-health-climate-crises-2023-7

[tracybirds]

Generally speaking: Mostly seabirds, such as petrels, gulls, boobys, etc. The island looks large enough to have small populations of land birds, so parakeets and other forest birds are possible, but I would assume that they are divergent from other areas as islands tend to host quite unique land animals due to the isolation (think of the Galapagos Island finches for a famous example!). It might also serve as a stopover during migration as Squiddo suggests. Species of gannets, albatrosses, godwits and plovers are all known to migrate to and from New Zealand as examples, so looking into birds that migrate across the Pacific could be a good start. There are more local migrations that occur too, but that might be a good start.

If you like the fanon placement of near the Kermadec Island chain (north-east of New Zealand and south of Tonga), which is strongly implied by TAG canon, then you might like to look into the wildlife present on Raoul Island, which is the largest in the Kermadec chain.

Te Ara Encyclopaedia has a short overview here and the Auckland Museum undertook an expedition to the region for the purpose of "biodiscovery" as they call it in 2011, and you can look at a lot of the bulletins and materials developed as a result from search 'kermadec' on their website (see here)

Hey, thunderbirds fandom I have a question. What types of birds would be on the island?

[biodiscovery-group]

FREE COURSE | AS A GIFT OF 10th ANNIVERSARY OF BDG LIFESCIENCES PREVIOUSLY KNOWN AS BIODISCOVERY GROUP. Register now to reserve your place here https://www.biodiscoverygroup.com/courses #bioinformatics #itsdifferentbybiodiscovery #biodiscoverygroup #biotechindia #bioinfoindia #bdglifesciences #biodiscovery #biotechnology #biotech #immunology #immunoinformatics #vaccine #epitope #allergy #bcell #tcell #virus #coronavirus https://www.instagram.com/p/B8fjgAMpXhN/?igshid=17g35dojctnj

[mikyit]

#NLP 😉🤖 has been utilized to aid various #processes 🚧 in #drug 💊 development lifecycle such as #GeneDisease 🧬 mapping, #biomarker 💉 discovery, #PatientTrial matching, drug #AdverseEvents ☠️ detection, etc.

These #applications commonly use #NLP functionalities of named entity #recognition, word #embeddings, entity resolution, #assertion status detection, #relation extraction, and topic #modeling.

Check here the state of the art: https://lnkd.in/e_yiwFne

[palbabor-writes]

testing, testing

@kugutsuu & @libiraki asked me about favorite positions/headcanons for Shigaraki, Dabi & Hawks & well, here we are 

warnings: ahahaha, this is dirty from the get, NSFW/18+ only, mild blood, impact play, emotional destress, sensory play

Tomura Shigaraki

i know i’ve done some, and by some i mean a plethora for him, what with those NSFW alphabet games, but those were on canon Tomura & i wanted to show off my Professor Shigaraki AU instead. who’s that you ask? you can read about the start of my University AU here.  

He would prefer to raw you from behind. 

That’s right, he’s not putting anything on. Sure, it’s risky but that’s part of your charm, for now.

It’s also on you for any kind of whoops, Plan B preventatives.

If you dare to email him about compensation for you emergency contraceptives, or your worry about the other after effects of your coupling, eh, that feels like a personal problem & he’ll be very upfront about telling you that. Honestly. He will not answer calls, or texts and it’ll likely come back as an email.

RE: about last night.... 

Regarding your previous email; I fail to see how this is relevant to our class and would prefer for you to cease and desist with these unprofessional, personal, emails. If you are needing support, please seek out the universities health and wellness resources.  

Remember, we have a midterm in two weeks. Please utilize all study halls and tutoring opportunities. My office hours are listed within the syllabus. 

All the best,

Tomura Shigaraki, Ph.D. 

Distinguished Research Professor/Associate Director of the BioDiscovery Institute of Biochemistry & Molecular Biology

Literally this is the email you will find waiting for you in your inbox. idc how much you think he ‘likes’ you - he’s got bigger fish to fry & if you’re getting too needy and he needs to cut you loose, so be it ❤️     

Alright. Now that that’s out of the way, back to the kinks!

He does like to fuck you in front of something reflective: a mirror, a window, polished metal, etc. - it lets him still see your face, but holds that barrier of aloofness and detached passion up. Keeping you at a safe arms length. It’s not like he doesn’t want to kiss you and he likes nipping and leaving marks on your skin, but it shatters his mask & he can’t have that - nope. not at all. 

Toward the end of each session he’ll make you get fully in your stomach and tell you to cross your legs. It makes you tighter and pushes the soft flesh of your ass deliciously against his sharp hipbones, giving him something to grind and rut against as he splays you out beneath him. 

It’s his go to when he’s tired & he wants to cum, there’s an early meeting tomorrow morning and he’s gotta rest. So stop being so fucking slippery and hold onto his cock, damn it.

Dabi

Dabi will likely prefer to have you on top. 

Ease of use only. It’s not like he likes the view. Of seeing your face roll through all of those sultry expressions, licking at his miss matched lips, a sharp canine catching against the burnt and heat blistered skin, holding back those groans and rumbling moans that keep threatening to escape his heaving throat as he watches you. 

No. It’s not that. It’s just easier. 

At least, that’s what he tells himself.  

Anyway. When you’re riding him it means that you’re doing most of the work. And if you’re doing most of the work then he doesn’t need to worry about you snatching at his shoulders, or cupping your arms around his neck, fingers dipping into his spiky hair. Your lips lowering, temptingly toward his own– 

nope.

There’s less risk this way. 

Besides, what happens if you jerk out a staple? Oh, fuck. Can you imagine? If your nails catch under one and just pull.  What would it feel like? Would it bring up a heady mixture of pleasure and pain that races through him? Making his cock throb and twitch, swelling with his want. Will his blood fall hot against your skin, that endless flame that sits within him smoking against you until you scream...

No.

Don’t do it.

Well, maybe just this once. Only once! Don’t think it’s gonna be a regular thing. 

Ahem. Another position he’d prefer is reverse cowgirl simply because he can do a bit of impact play.

He likes that lick and smack of his mangled hand against your curves. How you tighten over him, your cunt practically strangling his pulsing cock, making him leak another few beads of scalding precum within you. Yeah, you’ll shake if it does it in the same place twice and that’s just fucking perfect, ya’ know?  

If he’s in a pinch, in a rush between his missions, or waiting for his next rendezvous with the doctor, he’ll do what’s needed but he’d rather have you bent over something. 

The way your legs jut, how your ass presents itself to him, like an offering, your feet straining, hands plastered forward, snatching at whatever grip you can find, cunt blisteringly hot as it takes his straining length, over and over. Oooh, he likes this, he likes this so much he can’t think.

It hits the curve of his dick a little better when you’re half bent like this and he likes grabbing at your fleshiest parts, fingertips leaving bruises and cuts, marks that will stay with you until he returns. 

Hawks

For Hawks, I’d say he’s very, very sensitive. 

Part of it’s his wings & part of it is the fact that he simply doesn’t have the time to fuck much. 

So he’s gonna like to have you pressed into the mattress, wall, table, floor, whatever, ASAP. 

He’ll slow down once he’s gotten you stripped down. After all, he does like to look at you, to admire how pliant and spread you are, pussy glistening and your head turned toward him, a distant plea fading from your lips. 

Plus, when he’s fucking you from behind it’s easier for his wings stretch out behind him. 

He likes to fold them inward, against his back, when you go quiet, each feather feeling for your heartbeat, and when you’re loud, ahh, he likes to flap them. They gather up the sounds and ooze them all over the two of you, each wing beat whisking the vibrations forward and back, letting him soak up every moan and whine. That shit makes his legs shake and his pupils hone into a narrow slit, perfectly alert, and so, so hungry, ready for more and more and more. He wants you both to be a shivering heap of limbs and wings when he’s finished with you.

Speaking of, Hawks is a goddamn master at making you cum. Like, can have you so worked up that you’re doing it on his command. 

Once again, it helps that his wings can assist with this: they can feel out your pulse and sense tiny shifts in your breathing. But don’t think that’s all it is, after all, he’s also turned studying things into an art form. 

He’s memorized each shift that your face makes, how your eyes widen and then dampen, the way your nose scrunches and the sound your hands make when they scratch down the sheets. It’s all been filed away, slipped into some internal file that he can lift out with practiced ease. And fuck, does it makes him so hard, knowing that he can make you a gooey mess in seconds. 

Fully takes advantage of his feathers. He’s confident in his mastery of them and the tactile and sensory additions that they add to his game. 

Oh? You’re in an awkward position and he can’t touch you the way he wants? 

No worries, he can just send a smaller feather your way and have it frig and tweak your clit for him. 

I’d say his favorite position is to have one of your legs slung over his shoulders. 

It lets him pound into you just the way he likes, and, if he wants to switch up the tempo, he can feel how much it’s affecting you each time your thighs twitch. He also likes that he can kiss at your feet when he’s got you this way and your huffing laughs and half hearted squirms as he ruts into your slick pussy always, always make him smile. 

k, love you guys, bye.

[bpod-bpod]

Mushroom for Improvement

Burrowing into the brains of young caterpillars, Cordyceps militaris is a fungus with control in mind. Yet it also produces a “promising” natural chemical, cordycepin, shown to kill certain human cancer cells. Promising chemicals aren’t always practical or free from side effects, though, so establishing the underlying details is essential to their success in treating patients. Although Cordyceps has had a place in Chinese medicine for over 1500 years, cordycepin was first extracted from a bubbling mushroom broth in 1950. The intervening decades have revealed details carefully – challenged by the compound’s fast metabolism; cordycepin breaks down quickly inside living cells. Now, delving deeper into how cordycepin kills cells, scientists find exciting molecular clues: cordycepin is able to block growth factors that might otherwise help cancers grow, by guiding a set of intracellular signals known as mTOR. This information will be vital to fulfilling on the Cordyceps’ promise.

Written by John Ankers

Image by Holger Krisp from Wikimedia Commons

Research from the School of Pharmacy, Biodiscovery Institute, University of Nottingham, UK

Image originally published with a Creative Commons Attribution CC-BY-3.0

Research published in FEBS Letters, November 2024

You can also follow BPoD on Instagram, Twitter and Facebook

[rickrea]

🔥 https://t.co/EvCvNjGG84 Story→ Biodiscoveries: CELLINK is bioprinting its way into the future https://t.co/nn5QglNS4w https://t.co/LdIK3pHi8h rickyrea http://twitter.com/rickyrea/status/1120266009061937153 April 22, 2019 at 05:00AM

[joyfuldelusionchaosvaliant]

Science and Chemistry Classes

Scientists urge quick, deep, sweeping changes to halt and reverse dangerous biodiversity loss

- Group on Earth Observations Biodiversity Observation Network

24/01/2022

Halting, then reversing the dangerous, ongoing loss of Earth's plant and animal diversity requires far more than an expanded global system of protected areas of land and seas, scientists warned today.

Needed is successful, coordinated action across a diverse, interconnected set of "transformative" changes, including massive reductions in harmful agricultural and fishing subsidies, deep reductions in overconsumption, and holding climate change to 1.5°C.

More than 50 scientists from 23 countries today delivered to governments a synthesis of the science informing and underpinning 21 targets proposed in the draft 'post-2020 Global Biodiversity Framework' being negotiated under the UN Convention on Biological Diversity (CBD) and scheduled for adoption later this year at a world biodiversity summit in China.

The analysis was coordinated by two renowned international science bodies: bioDISCOVERY, a program of the Future Earth organization, and the Group on Earth Observations Biodiversity Observation Network (GEO BON).

Says Paul Leadley, an assessment leader, past chair of bioDISCOVERY, and Professor at Paris-Saclay University, France: "The target of protecting 30% of all land and seas is important and attracting a lot of attention. And expanding protected areas is a good start if done well, but far short of what's needed to halt and reverse biodiversity loss—called 'bending the curve' for biodiversity'. There's very good evidence that we will fail again to meet ambitious international biodiversity objectives if there's too much focus on protected areas at the expense of other urgent actions addressing the threats to biodiversity."

"Governments are clearly struggling with the breadth and depth of the 'transformative changes' needed to bend the curve for biodiversity, and sometimes seem unwilling to face up to it. But deep changes are necessary and will greatly benefit people in the long run."

The essential point, says bioDISCOVERY co-Chair Lynne Shannon, a Professor at the University of Cape Town, South Africa, is that "there is no one-to-one linkage from any action target to a specific milestone or goal; instead, 'many-to-many' relationships exist among them. We need to recognize, therefore, the complex relationships among targets, milestones and goals and undertake our planning and actions in an integrated manner."

Among the group's key conclusions and recommendations:

Success requires transformative change. Past experience in slowing and reversing biodiversity loss as well as scenarios of future biodiversity change show that only a comprehensive portfolio of interrelated actions will significantly reduce direct threats to biodiversity from land and sea use change, direct exploitation of organisms, climate change, pollution, and invasive alien species. None of the GBF targets that address these direct threats to biodiversity will alone contribute more than 15% of what's needed to reach the world's ultimate goals for ecosystems, species and genetic diversity.

Action must be coordinated at every scale, with progress assessed frequently. The degree of biodiversity change, and the relative importance of drivers, vary greatly across scales and from place to place, and drivers in one place can affect biodiversity in other places far away ("telecoupling," e.g. through global trade, climate change, etc). Success will require action coordinated across local, national and international levels, in natural and managed ecosystems, and across intact and 'working' lands and seas. Success will also require upgrading monitoring capability and regular assessment of progress to make sure actions are delivering the intended outcomes at all levels.

Substantial investment in better monitoring is needed to guide effective action. There are massive gaps in biodiversity monitoring. Most of the nearly 1 billion existing non-marine biodiversity-related records were collected in developed countries and within 2.5 km of roads, and less than 7% of the globe is sampled. Two key improvements needed: a) a global monitoring system for biodiversity with the ability to attribute biodiversity change to specific drivers, and to integrate data from relevant threat sectors (e.g. agriculture, trade, climate); and b) a predictive capacity to anticipate future trends, to inform decision-making.

Act now, and sustain it to ensure recovery. Given that the time lags between action and outcomes are often measured in decades, especially in such areas as restoration of forests, coral reefs and fisheries, it's imperative to act now to avoid irreversible loss and put biodiversity on a pathway to recovery by mid-century.

Says co-author Maria Cecilia Londoño Murcia of the Humboldt Institute, Colombia: "The sooner we act the better. Time lags between action and positive outcomes for biodiversity can take decades so we must act immediately and sustain our efforts if we are to reach the global goals by 2050. The time needed for safeguarding and restoring ecosystem structure, function and resilience is particularly critical for people and communities whose livelihoods and well-being directly depend on these systems and the benefits they provide."

Adds co-author David Obura, a distinguished scientist at the Coastal Oceans Research and Development (CORDIO), Kenya: "High levels of ambition for halting and reversing biodiversity loss will be critical. We underline, however, that this cannot be achieved just by conventional conservation actions".

"We show that the 21 Targets of the Global Biodiversity Framework essentially cover this broad gamut of indirect and direct drivers, but that no one Target can be implemented as a priority over the others to achieve success (other than providing the financial and other means necessary to implement all targets)."

[alyxagainsttheworld-blog]

Coral Bleaching

Coral bleaching is one of the most beautiful deaths that happen in a world so far away, but it's also one of the closest worlds to us, underwater. Under the surface of the water, we see things that we’ll never see on land. An environment so different you’d believe it if some told you it’s not from earth. Coral is part of one of the most important marine ecosystems, Coral Reefs. They provide food & shelter for over a quarter of the species in the ocean, most species are those which we eat. This is a remarkable fact considering that coral reefs only cover roughly 1% of the oceans floors, knowing those facts just add to the importance of these statistics. Rainforests of the ocean was a nickname given to coral reefs for its vast diversity of specimen, providing about 172 billion US dollars worldwide each year, with a majority of items that range from; food, medicines, nutrient recycling, jobs involving tourism, even protection of shorelines. With so much importance to the economy of the world, humans are the biggest threat to ruining such an ecosystem. Overfishing, water pollution, global warming, introduced species, destructive fishing & so much more are causing a lot of stress to these reefs. When coral is being put under too much stress, their polyps expelling algae until they die off, striping the coral of their vivid colors, leaving behind a white endoskeleton. Where once there was so much biodiversity, it turns into an underwater ghost town. If coral bleaching does happen to take place, there is still a short window of time to reverse the effects. In order to reverse the effects, we have to know what causes stress to coral reefs. Some of the main factors of coral bleaching are; change in the temperature of the water even if it changes by 2 degrees, ultraviolet lighting can play a role in the bleaching of coral. 

http://www.qm.qld.gov.au/microsites/biodiscovery/05human-impact/importance-of-coral-reefs.html

http://www.marinebiology.org/coralbleaching.htm

https://oceanservice.noaa.gov/facts/coral_bleach.html

https://ocean.si.edu/ocean-life/invertebrates/corals-and-coral-reefs

http://wwf.panda.org/our_work/oceans/coasts/coral_reefs/coral_importance/