#SERose

[joyffree]

🧐 This Week’s Spotlight Reads & Book Recommendations

➱ "Going on a road trip with four movie stars-will call later"

Like that isn't the opening line to what you know will be a grand adventure

The Road Trip Romance a Romantic Comedy by S.E. Rose

➱ In the shadow of alien threats, human-alien hybrid Abalim, armed with extraordinary psychic powers, embarks on a daring rescue across the cosmos

Abalim (Alien Legacy Brotherhood, #1) Alien Romance by Keri Kruspe

➱ In order to survive, they need to go against everything they’ve ever been taught. 

Destruction (Crimson Bonds) Dark MM/M Mafia by Abrianna Denae and Leigh Kenzie 

➱ I fell in love with a billionaire. I just didn’t know it. 

Bottles & Blades (Eagles Hockey: Oak Ridge Vineyards) Billionaire Age Gap Romance by Elise Faber

[allthingsdarkanddirty]

 NEW RELEASE 

We are excited to celebrate FALLING FOR THE FOOTBALL PLAYER by SE Rose & Sierra Hill is LIVE!

#1ClickHere https://www.amazon.com/dp/B0CWZRMBD8

AVAILABLE IN KINDLE UNLIMITED

Sometimes love can dropkick you in the footballs.

And other times, it can win the game.

When wild child and free spirit, Kelsie Dannon, returns from her semester abroad after a whirlwind romance, she brings home more than souvenirs. Her heart is freshly broken after being ghosted by the guy she fell for in Paris.

Now back at CFU, Kelsie is determined to forget all about Hayes McIntrye with copious amounts of parties and boys who won’t break her heart.

After a car accident that killed his friend and injured his brother, Hayes is a mess. He thought Paris would put enough distance between him and his problems, but it only created more. Transferring to CFU and joining the football team was his way to absolve his guilt and to live out someone else’s dreams: his brother’s.

But there’s no playbook for love or grief.

[moohnshinescorner]

THE BILLIONAIRE AND THE RUNAWAY

S.E. Rose Release Date: April 18

A wealthy college graduate who needs to escape her boring life. A small-town farmer who needs some help. And a job offer that will change everything. Ariana Titan hates her life. She has everything but doesn't want any of it. Her wealthy father controls every aspect of her days. Her apartment is starting to feel like a prison cell. She longs to run away to the countryside like in the movies she watches at night. When her father's girlfriend mentions a job posting for a social media marketing manager at a small town farm, she decides to apply…in person. She maybe fails to tell her father exactly where she's gone. Eric Windsor's farm needs a marketing makeover. He knows business but social media and online marketing are not his strong suits. He needs help and he needs it yesterday. When a young woman shows up at his property with a mile-long list of references and an impressive degree from a fancy university, he hires her on the spot. He soon figures out that his new employee is not only a fish out of water in his coastal town, but she also has the uncanny ability to bring a smile to his face, something that hasn't happened in a long time. Can Ariana stay afloat while grappling with her past amid a sea of marketing chaos, her overbearing father, and her new overprotective boss? While she fights to swim instead of sink, one burning question remains in her mind: will her mysterious farmer employer be part of her future?

Grab your copy! https://books2read.com/u/4jBp0Z

MY REVIEW

Oh my this was such an adorable and fun read. I mean come on, baby Thor is just soooo cute. I want to snuggle with the little kitty. Ok back to the review.

This story was a fun and entertaining read. Ari is an heiress whom has recently graduated university. She is trying to find her way in life and her controlling father is getting in the way. So she disappears to a small town to work as a social media marketing manager of a small farm.

From the very first time they meet Ari and Eric are drawn to each other. With secrets in their pasts they rather not share, they embark on a journey. Neither one of our main characters could have imagined the outcome.

This book was enjoyable and a perfect romantic comedy. The characters are complex, caring, kind and sweet. Ari is like a butterfly finding her wings and Eric is a lost soul coming out of the dark. Their love story is exciting and butterfly in belly inducing. The book centers on a farm so there are plenty of cute animals and their crazy antics.

Overall this book has it all. From romance to comedy, this book is sure to have something for everyone. It is a sweet and beautiful story full of heat and passion. If it wasn't for all the steamy fire inducing scenes, then this book would be Hallmark Movie worthy. This guaranteed happy ending is sure to pull at your heartstrings and like the Grinch grow with all the love.

I did not read the first two books in the series, but this book was a perfect stand-alone read. I did not feel as if I had to read them in order. It wasn't confusing or missing anything. It was pure perfection.

Meet SE Rose:

USA Today & International Bestselling romance author, S.E. Rose lives near Washington D.C. with her family. When she's not wrangling her cats or keeping up with her kids, she's plotting her next story. She loves all things wine, coffee, and cats. In her non-existent free time, she enjoys traveling, going to concerts, binging on her favorite shows, and reading, especially if it's a good mystery or comedy. 

Keep up with S.E. Rose and subscribe to her newsletter: https://bookhip.com/LSMKWL

To learn more about S.E. Rose & her books, visit here! Connect with S.E. Rose: https://linktr.ee/seroseauthor

[tempcrarysecretary2]

pspsps look at . harrier du bois gets stomped bu a horse before gta6 pspsps beckons you pspspps

...yes yes funy....now here's my serios art yes at first I lol'd than I serosed.....

(body junk)

[niyxxe]

since there's been a rise of questioning about how and why zhuyan didn't cause destruction the many years before That One Blood Moon Night Where He Killed His Best Friend and Future Boyfriend's Family and i think the answer is.

lilun was with him. i have many to say about it in full serosity, especially if you think about it, it certainly is the obvious answer. but i'm going to take the other approach and be a little annoying about it.

well, honestly. in abo terms, it's kinda like being in heat and not having a (mated) partner to get through it. someone to suppress all that bursting energy. lilun was there with him his entire life, that One blood moon night he wasn't, rampage and chaos ensued.

[justkidneying]

Okay so magic as something the body sees as a threat/danger to the body...

And this ask may return in varying levels as I refine it and get a better understanding of the subject

What if the body had a low-level immune response to using magic--like it isn't at an autoimmune disorder (yet, possibly)? Would there be a fever to try and purge whatever it is (that the body can't find)? Or would it immediately start escalating to an auto-immune response?

Okay, I love this question. So to answer it, I'm gonna have to 1) explain the immune system and how autoimmune disprders work, and 2) figure out how magic can be physical in a way for the immune system to respond to it.

So first off, your immune system has two main parts: innate (you're born with this) and adaptive (you develop this). Adaptive is the important one here. It deals with B cells, T cells, antibodies, stuff like that. It is specific, regulated, and has a memory. It also has to have tolerance. Tolerance is when these immune cells recognize the self and don't attack. Autoimmune disorders are the failure of this ability. Cells can't distinguish the self from the non-self, so they develop an immune response to your own cells. So to answer the first part, any attack on the self is an autoimmune disorder. There's not really an in-between.

The reason behind autoimmunity is largely unknown and too grand for this tumblr post (it's a lot of genetics stuff, as well as environment), so we're gonna fast foward a bit to what happens when your immune system attacks you. I will note though, that autoimmune disorders are most common in young adult females (probably something to do with hormones at that age, like estrogen).

ANYWAYS, so...what's going to happen is that the immune cells start attacking your cells and killing them. If the beta cells of the pancreas are killed, thats Type 1 Diabetes. If the joints are attacked, that's Rheumatoid Arthritis. There's also Lupus, Scleroderma, Sjögren, etc. I'm not going to get into all of this here, but you get the point: DISEASE.

What are some symptoms related to autoimmune disorders? That's complicated because there are so many and they act on so many types of cells, that the symptoms are specific to each disease. But, I like Systemic Lupus Erthematosus because it has a lot of systemic symptoms due to the body attacking your DNA. These include: a rash on the cheeks (malar rash), arthritis, inflammation of serosal surfaces (like oral mucosa), kidney injury, psychosis, seizures, oral ulcers, and a decrease in cell types (like RBCs and WBCs). This can cause a low grade fever, photosensitivity, fatigue, muscle aches, loss of appetite, inflammation of the heart and lungs, and poor circulation to the fingers and toes.

Now onto the next part: magic autoimmune disorder. So we're going to assume that using magic goes along with having a certain type of cell. We'll call this a magicyte. We can say this cell type is increased in the blood when the user is doing magic stuff.

In our hypothetical, the immune system can no longer recognize magicytes as self and begins to attack and kill these cells. This will probably lead to a decreased ability or even an inability to do magic (like how people with DM1 can't make insulin). We can also say that there may be a low-grade fever due to immune system activation. Remember how I said adaptive immunity is specific? Well, that's good because it probably won't do much else. Lupus is really bad because DNA is attacked, so that fucks with a lot of cells. As long as magicytes are the only targets of this response, the person will probably only lose their ability to do magic. Systemic stuff like fever will probably appear after they attempt to use magic (thus increasing the number of those cells and increasing immune response).

I hope this answered your question, and thanks for the ask :))

[biomedres]

Pathophysiology of Vascular Manifestations in Systemic Lupus Erythematosus

Pathophysiology of Vascular Manifestations in Systemic Lupus Erythematosus in Biomedical Journal of Scientific & Technical Research

Systemic Lupus Erythematosus (SLE) is a potentially fatal, chronic, multisystem autoimmune disorder. As defects can occur in various parts of the immune cascade, clinical presentations may vary significantly [1]. These clinical features range from musculoskeletal to neuropsychiatric, renal, cutaneous, gastrointestinal, pulmonary, cardiac, vascular, haematological, ophthalmological and immunological manifestations [2]. In a prospective, Europewide, decade-long study, the most common symptoms of SLE were arthritis, malar rash, nephropathy, photosensitivity, neurologic symptoms, fever, Raynaud’s phenomenon, serositis, thrombocytopenia and oral ulcers [3]. Notably, coronary heart disease, atherosclerosis and thrombosis are common in SLE [4,5], and small- and medium-vessel vasculitis across affected organ systems prevail in up to 36 % of SLE cases [6]. Adding to the complexity of the disease are varying laboratory abnormalities‚ from hematological and serological changes to negative serology or the occurrence of specific autoantibodies [1]. SLE predominantly affects women between puberty and menopause, which suggests an endocrine influence on disease onset and progression. This is underpinned by the fact that the female-to-male ratio in children is rather low and increases significantly in childbearing age [7].

For more articles in Journals on Biomedical Sciences click here bjstr

Follow on Twitter : https://twitter.com/Biomedres01/ Follow on Blogger : https://biomedres01.blogspot.com/ Like Our Pins On : https://www.pinterest.com/biomedres/

[gastroenterologistpretoria]

Understanding Eosinophilic Gastroenteritis: A Rare But Impactful Digestive Disorder

Eosinophilic Gastroenteritis (EGE) is a rare and often misunderstood condition that affects the gastrointestinal (GI) tract. It is characterized by an abnormal accumulation of eosinophils—a type of white blood cell involved in allergic reactions—in various layers of the GI tract, particularly the stomach and small intestine. This chronic inflammatory condition can lead to a range of symptoms, some of which may significantly impact a person's quality of life.

What Are Eosinophils and Why Do They Matter?

Eosinophils play a key role in the body’s immune response, especially in combating parasitic infections and mediating allergic reactions. Under normal circumstances, eosinophils are not present in significant numbers in the lining of the gastrointestinal tract. However, in individuals with EGE, these cells infiltrate the GI tissues without any known parasitic infection or other identifiable cause.

This accumulation leads to inflammation, tissue damage, and a range of gastrointestinal symptoms depending on which part of the GI tract is affected and the depth of eosinophilic infiltration—mucosal, muscular, or serosal.

Symptoms of Eosinophilic Gastroenteritis

The symptoms of EGE can vary widely depending on the site and extent of eosinophil involvement. Common symptoms include:

Abdominal pain or cramping

Nausea and vomiting

Diarrhea or constipation

Weight loss or poor appetite

Bloating and gas

Anemia (due to gastrointestinal bleeding)

Protein-losing enteropathy (loss of protein through the gut)

In rare cases where the serosal layer (outermost GI layer) is involved, patients may develop ascites—fluid accumulation in the abdomen—leading to visible swelling and discomfort.

Causes and Risk Factors

The exact cause of EGE is still not fully understood. However, it is thought to have an allergic or immune-mediated basis. Many patients with EGE have a history of atopic conditions such as:

Food allergies

Asthma

Eczema

Allergic rhinitis

Food allergens are suspected to play a role in triggering the eosinophilic response in some patients, although pinpointing the exact trigger can be challenging.

Diagnosis

Diagnosing Eosinophilic Gastroenteritis can be complex due to its rarity and the nonspecific nature of its symptoms. A combination of clinical evaluation, laboratory tests, imaging, and endoscopic procedures is often needed.

Key diagnostic steps include:

Blood Tests: Elevated eosinophil count in the peripheral blood may suggest the condition but is not definitive.

Stool Examination: To rule out parasitic infections that can also elevate eosinophil levels.

Endoscopy with Biopsy: This is the most important diagnostic tool. It allows for direct visualization of the GI tract and collection of tissue samples, which are then examined for eosinophil infiltration.

Imaging: CT scans or ultrasounds can help detect thickening of the GI wall or fluid accumulation.

Treatment Options

There is no standardized treatment for EGE, but several effective management strategies have been developed based on the individual’s symptoms and disease severity.

1. Dietary Therapy: Elimination diets, where potential allergenic foods are removed, have shown promise—particularly in patients with confirmed food sensitivities. Common allergens include dairy, soy, eggs, wheat, peanuts, and seafood.

2. Corticosteroids: Steroids such as prednisone are the mainstay of treatment, especially for moderate to severe cases. They help reduce inflammation quickly but are not suitable for long-term use due to potential side effects.

3. Other Medications: Leukotriene inhibitors, mast cell stabilizers, and monoclonal antibodies targeting interleukins (e.g., IL-5 inhibitors) are emerging therapies showing promise in research and clinical trials.

4. Nutritional Support: In severe cases with malabsorption or weight loss, nutritional support via supplements or even feeding tubes may be required.

Long-Term Outlook

Eosinophilic Gastroenteritis tends to follow a relapsing-remitting course. With proper management, many patients can achieve symptom control and lead a relatively normal life. However, ongoing monitoring is essential to adjust treatment plans, identify triggers, and prevent complications such as intestinal obstruction or chronic malnutrition.

Conclusion

Though rare, Eosinophilic Gastroenteritis is a significant condition that can profoundly impact a person’s digestive health. Increased awareness among healthcare providers and patients alike is essential for early recognition and effective management. With advances in understanding the allergic and immunologic components of the disease, the future holds promise for more targeted and less invasive therapies.

If you or someone you know experiences persistent digestive issues—especially in the context of allergies—it’s worth discussing the possibility of EGE with a gastroenterologist.

[qubixo1]

World Rose Selling 19.1% in 2024 and hit twice 2025 because of AI | Heart

Global Semicouct chip sell Hudor 19.1% up to $ 627.6 billion in 2024 and size is expected of the number of two numbers in 2025, according to the Semiconductocutoc (And). Sia said 2024 numbers hit a new profile and compared with $ 526.8 billion. The intention, it was the most important thing for Ai Serosers and memorizing, ADo Neufferger, CEO of SIA SIMA, a group of chip, in conversation with…

[joyffree]

These five new and old friends are about to embark on a journey that will change their lives.

THE ROAD TRIP ROMANCE a Romantic Comedy by S.E. Rose Release Blitz

Sophia Walsh has given up on her happily ever after. This divorced mom of two feels destined to live her mundane suburban life. That is until a movie star pops into her world, and changes everything.

[allthingsdarkanddirty]

We are excited to share with you FALLING FOR THE FAKE BOYFRIEND by SE Rose and Sierra Hill is FREE for a limited time!

Grab your copy here!  https://www.amazon.com/dp/B0BVJQCXNN

Available in KU

One football player.

Two simple rules.

Three fake dates.

Zero chance of falling for the other.

Emmett Hudson is just trying to play college football at Clearview Falls University while keeping all the balls from spinning his life apart. He thought he had everything under control until the coach threatened to bench him if he didn’t get his grades up with the help of a tutor.

Lucy Parker isn’t into football players, except the one she’s crushed on since high school. But he’s the star quarterback and doesn’t even know she exists.

The answer to this problem comes when a deal is struck with her new tutoring assignment, aka: Emmett. He promises a way to get his teammate’s attention if Lucy commits to being his fake girlfriend for three dates.

Three. Seems easy enough. Right?

But even with safeguards in place, their fake relationship soon begins to feel more real than either Lucy or Emmett expects.

And with their hearts on the line, it could turn this winning strategy into a losing proposition.

[schlauemaus]

Glässer´sche Krankheit

Erreger: Glaesserella parasuis (früher Haemophilus parasuis) Kommensale im Nasen-Rachenraum

Übertragung:

oronasale Aufnahme -> Nasen-Rachenraum -> untere Atemwege/ Bakteriämie

Symptome: betrifft va. Aufzucht u. Mastbeginn; bei Neueinschleppung alle Altersgruppen Faktorenkrankheit! -> Auslöser Stress (Transport, Umstallen), Abfall maternaler Antikörper mit ca. 6 Wochen Verlauf abhängig v. Serotyp, Immunitätslage, KoFaktoren und betroffenen Lokalisationen

Perakuter Verlauf:

Sepsis

plötzliches Versterben

Akuter Verlauf: je nach betroffenem Organsystem

Fieber

Anorexie

Apathie

ZNS-Symptomatik

Ruderbewegungen Seitenlage Hinterhandlähmung Kreisbewegungen Ataxie

Arthritiden:

geschwollene Gelenke Lahmheiten

Polyserositis:

Kyphotische Rückenlinie Dyspnoe Zyanosen bei Auskultation Reibegeräusche undulierendes Abdomen (wg. Flüssigkeitsansammlung im Bauchraum)

Chronischer Verlauf:

Kümmern

Husten

Dyspnoe

Lahmheiten

struppiges Haarkleid

chronische Arthritiden

Diagnose

Sektion:

ZNS: Leptomenengitis fibrinopurulenta, evtl. mit Meningoenzephalitis Arthritiden: Synovia trüb mit Fibrinfäden (fibrinopurulente Entzündung) Serositis: Fibrin u/o Flüssigkeitsansammlungen in Herzbeutel, Bauch- u/o Brustraum (fibrinöse Polyserositis v. Perikard, Pleura u. Peritoneum)

Direkter Erregernachweis:

Probenmaterial je nach betroffener Lokalisation: Tupfer mit Medium verwenden! ZNS: Liquor cerebrospinalis, Gehirnhauttupfer Arthritis: Gelenkspunktat, -tupfer od. -kapsel Serositis: Serosentupfer v Peritoneum/Perikard/Pleura !Naserachenraum/ Lunge/ Lavage eignet sich NICHT, da Glaesserella dort ein Kommensale ist -> keine Aussagekraft! mittels Kultur (schwierig) und anschließender Resistenztestung mittels PCR und anschließende Serotypisierung (relevant wg. Impfstoff)

Antikörpernachweis:

mittels ELISA wenig aussagekräftig wg. weiter Verbreitung + Vorkommen als Kommensale + verschiedene Serotypen

Prophylaxe

Rein-Raus-Verfahren

korrekte Reinigung u. Desinfektion

Zukauf v. möglichst wenigen Herkünften

Stress minimieren (Belegdichte, Transport, Fressplatzverhältnis)

Stallklima optimieren

Impfen: Totimpfstoff (ab 5. Lebenswoche), auch als Kombi mit Mycoplasma hyopneumoniae (ab 7. Lebenstag) erhältlich od. stallspezifische Vakzine evtl. Impfen v. Jungsauen vor Einstallung sinnvoll !Kreuzprotektivität zw. Serotypen veriabel u. nicht vorhersehbar!

Kolostrumversorgung gewährleisten

korrekte Jungsaueneingliederung

Vorgehen gegen andere Erreger

Therapie

Antibiose nach Antibiogramm

[irfacilities]

NON SURGICAL TREATMENT OF FIBROID

The female reproductive system consists of the uterus, which is supported by two ovaries and fallopian tubes. The uterus undergoes continuous cycles throughout the menstrual phase with the shedding of the endometrium under the impact of various hormones produced by the ovaries or elsewhere in the body. The female uterus is predisposed to multiple problems, and one of the major problems is the development of fibroids.

Fibroids are a form of abnormal proliferation of the uterine myometrium, leading to the formation of multiple-sized and variably located lesions. The uterus mainly consists of the endometrium, which is the inner layer, myometrium, which is the middle layer, and the serosal outside layer.

Fortunately, non-surgical treatment of fibroid options is available for women who want to avoid invasive procedures. These treatments target the fibroids while preserving the uterus, offering relief without the need for surgery.

Fibroids are mainly formed in the myometrium. However, their location can be variable based on where they develop. Fibroid can be divided into submucosal, which are lying close to the endometrium, intramural, which are lying in the myometrium and subserosal which are towards the outer layer of the uterus. Depending on the location, a fibroid can present multiple symptoms. A few of the major symptoms include abnormal cyclical bleeding, which can contribute in the form of increased bleeding during the normal cyclic phase or increased bleeding can happen in between the normal cycles.

Other important symptoms include pressure effects which are mainly caused by the subserosal fibroids, leading to repeated urine urges due to pressure on the bladder. The patient can experience abnormal heaviness in the lower abdomen and pelvic area. Fibroid can hinder the pregnancy also as it can prevent the implantation of the embryo.                                                                                             

Different forms of treatments are available for the treatment of fibroid, which includes traditional ayurvedic treatments, and surgical treatments in the form of removal of the uterus itself partially or completely. However this treatment has multiple limitations in the form of removal of the uterus itself, and this cannot be done in the early phases of female life where pregnancy is still desired. There are multiple other side-effects of early removal of the uterus like hormonal imbalance, and reduced bone density, leading to fractures and bone pain. New forms of treatment are available that prevent surgical interference. One of the major upcoming treatments for fibroid is endovascular treatment in the form of uterine artery embolization. This is a minimally invasive procedure with minimal complications and minimal hospital stay. 

The procedure is carried out through an endovascular route with the placement of a short access sheath in the inguinal area. The basic principle behind the treatment is to stop the selective arterial supply of the fibroids, which not only prevents the further growth of the fibroid but also helps in the necrosis and ultimate reduction in the size of the fibroid. The procedure is carried out mostly through the femoral access and uses multiple catheters to selectively cannulate the uterine artery. Further multiple microcatheters are used to selectively identify the supply of the fibroids and small PVA particles of variable size are used to penetrate the substance of the fibroid to induce necrosis. Multiple agents are used to occlude the parent including glue gel foam or coils.

Endovascular uterine artery embolization has distinct advantages over the traditional forms of treatment as it not only saves the patient from a long hospital stay but also no major blood loss during the procedure. Patients can be discharged within a day or two after the procedure and can start the normal routine in a day or two major cuts or sutures are seen in the procedure as there is only small access through the vessels. The endovascular treatment is done in the Cath lab, which is a specialized X-ray machine for the procedure.

The patient remains awake throughout the procedure with no major anesthesia. Only a few of the minor complications that can happen include pain during embolization which can be easily managed through the medications. The procedure not only prevents the removal of the uterus but also prevents major unwanted hysterectomy and associated complications. 

All the major surgical treatments available for the treatment of the fibroids include partial or complete removal of the uterus which not only hinders the future pregnancy options but also exposes them to variable complications. All the major types of fibroids can be dealt with through the endovascular treatment. However, intermural fibroid gives the best results. The endovascular treatment is done by the intervention radiologist who are the specialised trained doctors in this field.                                                                                

IRFACILITIES is a group of experienced intervention radiologists under the guidance of dr Sandeep Sharma. The group of doctors has wide experience in the treatment of fibroids and their complications. The group has wide experience in the treatment of fibroids not only in domestic patients but also in international patients. IRfacilities believe in providing end-to-end treatment to the patient. It has a dedicated helpline from where patients can gain information regarding the disease but also can talk to the doctors about the problems associated with the fibroid and its treatment. Even after the procedure, the patient can stay in regular touch with the Team and can resolve all the major problems.            

[endometrial-cancer-surgery-delhi]

Expert Endometrial Cancer Surgery in Delhi by Dr. Kanika Batra Modi

Endometrial Cancer Surgery in Delhi: A Comprehensive Guide

INTRODUCTION

Endometrial cancer surgery in Delhi offers advanced, minimally invasive procedures ensuring optimal outcomes with lower morbidity, including robotic and laparoscopic options.

After lung, colorectal, and breast cancer, endometrial cancer is the most frequent cancer of the female genital tract in the Western world, occurring in around 400,000 cases annually. About 5 percent of cases are due to genetic alterations, which usually happen 10–20 years earlier and are often caused by random mutations. Obesity, early menarche, late menopause, estrogen-secreting tumors, PCOD, unopposed estrogen exposure, tamoxifen medication, HPNCC, nulliparity, diabetes mellitus, hypertension, and prior radiation therapy are important risk factors.

Symptoms and Diagnosis

Common symptoms of endometrial cancer include abnormal vaginal bleeding, postmenopausal bleeding, intermenstrual bleeding, heavy and prolonged periods, and purulent vaginal discharge. Among the causes of postmenopausal bleeding, endometrial cancer accounts for 15%.

Diagnosis typically involves an office endometrial biopsy with endocervical curettage, though hysteroscopy and directed biopsy may also be necessary.

Surgical Management

For endometrial cancer surgery in Delhi, the standard procedure includes a hysterectomy with bilateral salpingo-oophorectomy (BSO) and surgical staging. Sentinel lymph node biopsy is recommended for uterine-confined low and intermediate-risk histologies. During surgery, visual inspection of peritoneal, diaphragmatic, and serosal surfaces is performed, and any suspicious lesions are biopsied. Peritoneal cytology is collected and reported, though it does not affect staging.

In cases with high-risk histology, complete pelvic and retroperitoneal lymph node dissection is conducted. Excision of suspicious and enlarged lymph nodes in the pelvic and retroperitoneal region is also performed.

Minimally Invasive Surgery

Minimally invasive surgery (MIS),such as laparoscopy, has shown lower morbidity compared to laparotomy, with no significant differences in survival and recurrence rates. Robotic surgery is FDA-approved for treating endometrial cancer.

Adjuvant Therapy

Depending on the final histopathological evaluation, adjuvant treatment may be required in select cases to ensure comprehensive treatment.

Endometrial cancer surgery in Delhi ensures patients receive advanced surgical options and care, aiming for the best outcomes with minimally invasive techniques and thorough management.

[rnomics]

Cells, Vol. 13, Pages 1211: Tissue-Level Integration Overrides Gradations of Differentiating Cell Identity in Beetle Extraembryonic Tissue

During animal embryogenesis, one of the earliest specification events distinguishes extraembryonic (EE) from embryonic tissue fates: the serosa in the case of the insects. While it is well established that the homeodomain transcription factor Zen1 is the critical determinant of the serosa, the subsequent realization of this tissue’s identity has not been investigated. Here, we examine serosal differentiation in the beetle Tribolium castaneum based on the quantification of morphological and morphogenetic features, comparing embryos from a Tc-zen1 #RNAi dilution series, where complete knockdown results in amnion-only EE tissue identity. We assess features including cell density, tissue boundary morphology, and nuclear size as dynamic readouts for progressive tissue maturation. While some features exhibit an all-or-nothing outcome, other key features show dose-dependent phenotypic responses with trait-specific thresholds. Collectively, these findings provide nuance beyond the known status of Tc-Zen1 as a selector gene for serosal tissue patterning. Overall, our approach illustrates how the analysis of tissue maturation dynamics from live imaging extends but also challenges interpretations based on gene expression data, refining our understanding of tissue identity and when it is achieved. https://www.mdpi.com/2073-4409/13/14/1211?utm_source=dlvr.it&utm_medium=tumblr

[hemant187]

CERVICAL FIBROIDS

Cervical myomas (also known as cervical fibroids) are smooth, round benign tumors composed mostly of muscle tissue. These fibroids are present in the cervix, the lower part of the uterus, and are rare. They are usually accompanied by uterine fibroids, in the larger upper part of the uterus. Based on their location, cervical myomas can be classified as extra cervical (sub-serosal myoma) and intracervical. Cervical fibroids can further be anterior, posterior, lateral, and central depending on their position.

There are different types of uterine fibroids depending on where they’re located and how they attach. Specific types of uterine fibroids include:

Intramural fibroids:  Intramural fibroids are the most common type and they are embedded into the muscular wall of your uterus.

Submucosal fibroids: These fibroids grow under the inner lining of your uterus.

Subserosal fibroids: Subserosal fibroids grow under the lining of the outer surface of your uterus. They can become quite large and grow into your pelvis.

Pedunculated fibroids: These are the least common type of fibroids and they attach to your uterus with a stalk or stem. They’re often described as mushroom-like because they have a stalk and then a wider top.

  However, they can cause serious problems in some cases, especially if they are large. They may block part of the urinary tract or prolapse through the cervix and into the vaginal canal. Prolapsed myomas may develop ulcers, which could cause abnormal bleeding or infection.

 Causes:

Most cervical fibroids eventually cause symptoms. It’s unclear why fibroids develop. A couple of different factors may influence their formation:

Hormones: The ovaries produce estrogen and progesterone. These hormones cause the uterine lining to regenerate during each menstrual cycle and stimulate the growth of fibroids.

Family history: Fibroids may run in the family. If your mother, sister, or grandmother has a history of this condition, you may develop it as well.

Risk factors:

People are at greater risk of developing fibroids if they have one or more of the following risk factors:

Due to their family history 

If they are 30 years or above

Body weight is high.

The surgical treatment of cervical leiomyomas poses more difficulty; due to the risk of intraoperative Hemorrhage and the potential injuries because of contiguity and dislocation of adjacent organs.

Symptoms:

Mild cervical myomas may not cause any problems while moderate to severe myomas may cause one or more of these symptoms:

1. Painful or excessive bleeding during the period.

2. Bleeding between your periods.

3. Menstrual clots.

4. Anemia, as a result of heavy bleeding, accompanied by fatigue

5. A feeling of fullness in your lower belly (abdomen)/bloating.

6. Frequent urination (this can happen when a fibroid puts pressure on your bladder).

7. Dyspareunia

8. Low back pain and pain in the pelvis.

9. Constipation or feeling pressure on your rectum.

10. Long-term (chronic) vaginal discharge.

11. Inability to pee or empty your bladder.

12. Increased abdominal distention (enlargement), causes your abdomen to look pregnant.

The symptoms of uterine fibroids usually stabilize or go away after you’ve gone through menopause because hormone levels decline within your body.

Treatment:

Small myomas that do not cause symptoms may not need to be treated. However large fibroids/myomas that are causing pain, bleeding, or urinary problems can be surgically removed via myomectomy. Depending on the size and location of the cervical fibroid/myomas, the doctor may perform one of three procedures.

Drug therapy may be an option for some women with fibroids/myomas. Heavy bleeding and painful menstrual cycle caused by fibroids/myomas may be controlled with medications. They may not prevent the growth of cervical myomas. Surgery may not be avoidable. Drug treatment for fibroids includes the following options:

Birth control pills (oral contraceptives) and other types of hormonal birth control methods: These drugs often are used to control heavy bleeding and painful periods.

Gonadotropin-releasing hormone (GnRH) agonists: These drugs stop the menstrual cycle and can shrink fibroids. They sometimes are used before surgery to reduce the risk of bleeding.

Progestin intrauterine device (IUD): An option for women with myomas that does not distort the inside of the uterus. It reduces heavy and painful bleeding. The medication does not treat the myomas.

Laparoscopy

A procedure in which the surgeon conducts the operation through one or more tiny incisions near the belly button. A thin, flexible, lighted instrument, called a laparoscope, helps the doctor to see the surgical site.

Laparotomy

 It is an open surgical procedure in which the surgeon removes the myomas through a larger abdominal incision.

Hysterectomy

Complete surgical removal of the uterus and sometimes the ovaries. If the fibroids are very large, this may be the surgeon’s only option. After a hysterectomy, the female patient can no longer become pregnant. 

conclusion:

These are the fibroids that are present in the cervix and different factors like hormonal imbalance or family history might be the cause. Anemia and pain in the abdomen are the common symptoms. The basic treatment is myomectomy, in some cases, mediation is used. Treatments like laparoscopy, laparotomy, and hysterectomy are surgical procedures to remove fibroids.