#Technical Training Program
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akshayroy123 · 1 year ago
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Technical Training Program
A technical training program is a structured initiative designed to equip individuals with the knowledge, skills, and competencies required to excel in specific technical domains. These programs are essential for professionals seeking to stay abreast of emerging technologies, enhance their expertise, and remain competitive in dynamic industries. Key components of a successful technical training program include comprehensive curriculum development, hands-on practical exercises, interactive learning experiences, and access to expert instructors. The curriculum should be carefully crafted to cover a wide range of topics relevant to the target audience, including but not limited to programming languages, software development methodologies, network infrastructure, cybersecurity protocols, and system administration. Hands-on practical exercises are crucial for reinforcing theoretical concepts and allowing participants to apply their knowledge in real-world scenarios. Through lab sessions, simulation exercises, and project-based assignments, trainees can gain valuable hands-on experience and develop problem-solving skills essential for success in technical roles.
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cent-scratchnsniff · 7 months ago
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messy doodles plus with some picked ramblings with them as i process, learn, and progress. yes only some out of many. i talk far too much. i missed so much too im just too tired to talk abt those aspects rifht now
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#library of ruina#lobotomy corporation#lobotomy corp spoilers#technically i talk abt them less of draw them#just incase though#hod#hod lor#yesod#technically both lobcorp and lor uhh i think ill just do one tag for all since theyre sketchy doodles#malkuth#netzach#there was another for fragment of the universe. fragments ego gear talking abt ignoring it and dimissing it and what it attempts to#communicate and speak. netzach commonly speaking in l corp and then adding some parts long the lines of yeah just keep ignoring me or the#sort along with commonly being dismissed as just a 'druggie' or another along those words. late and cant get exact quotes but relatively#that. there is rambles for yesod too but... ahhhhhh i talk far FAR too much. essentally ive talked abt every piece of dialog and keter floo#as well. its ah. it sure is... a floor! oh dear.....#just got to warp train <3 only that for urban legend iirc it was called. got too tired after progessing#when i say more work than needed w hod its to where her instructions on how to suppress and deal w a breaching abno is noted in the safet#teams description to be their job kinda. training is explicitly only noted to get employees adjusted to their new departments and to enforce#slash teach policies and Management procedures. which isnt really suppressions of individual abnos that she was showing in story 5 of her#l corp dialog. that and in abno stories its listed there is already a therapy program that people go do after certain requirments as company#enforced procedure which is when they panic and attack another iirc. which means the COMPULSORY counseling was a whole seprate thing hod#created. thats what i mean by more work than needed. not quite sure what informatiok holds up vut its what i gleaned from l corp
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fat-rolls-frictions · 2 years ago
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document added to your inventory. transcript below.
CW: referenced self-harm, implied teeth horror, torture, unreality. @fiddles-ifs
(The document is marked as CONFIDENTIAL with various administration stamps and handwritten notes on the top margin. Much of the dates and serial numbers are illegible.
A ring stain from a cup is clearly visible on the bottom right corner.)
PARANORMAL INTELLIGENCE AND RESEARCH AGENCY
TRAINEE EVALUATION REPORT
Trainee's Name: Nguyen, Kim
Subject: Mission no.06 - Simulated Interrogation
Handlers: A. Itamura, V. Wallace
(Scattered throughout are fragmented phrases. They read: "who were?" "do you even care? do you" "you did not" "remember" "do you ever? di")
Addendum-120320A: Agents reported "unexpected" degree of resistance. Preliminary injuries logged. Mission proceeded without further complications.
("They have pliers.")
Overview: Trainee's previously recorded paranoia exacerbated after preparation period. Roommates reported heightened stress unrelated to anticipation of mission; effect attributed directly to trainee. Arrangements for extraction made with regards to trainee's evals and Dr. (redacted)'s suggestions.
Proceeding:
Trainee exhibited remarkable contentiousness despite several injuries, including a fractured collarbone and mild concussion. Agents instructed to secure with force given trainee's well documented volatility. Mission hook revealed. Dr. (redacted) correctly predicted that trainee would fail to respond to accusations of collaborating, or otherwise spearheading, the information leaks. Agents instructed to proceed with physical methodologies.
Stalemate achieved approx. 0500 hours after agent Itamura di ("his hands on your this pulp is not yours"). Trainee made multiple attempts to ("retaliate / retribute / requiter / illegible text"). Evidently unsuccessful (See A-120320B below). Trainee continued to redirect attention away from mission hook, oftentimes inciting, and appearing to relish retribution from agents. Previous psychological evals point to this being a product of mere belligerence. [break] ("It's the only thing you're capable of.") Nevertheless, agents pursued this lead to its completion, as is protocol.
Agent Wallace discovered healing injuries unrelated to mission at the 0619 hour mark. Injuries appear to be self-inflicted in nature, located in both inner arms. It was surmised that [break] teeth [break] match ("you didn't mean to but it happened what kind of person do this it just happened" "you" "tear into" "fuck off") unexpected emotional and psychological reactions. Agents authorized to remove part of trainee's sleeve in order to continue the interrogation.
(Overlay in the break, nearly illegible: "they pour water down your throat and it comes spilling out then he (illegible) hands teach you again the shape of your jaws you know intimately someone stupider would say-")
Incident C133-120320 took place at 0922 hours when agent Itamura prepared to [break] after several threats to [break] if trainee did not ("repent"). Neither agents anticipated the outburst. Agent Wallace remarked that [break] ("pliers")
("-bunny". The word "bunny" repeats several times after this instance in the margins.)
("sometimes you see people they do not stop even when they should even when" "metal on molars on gum on tongue" "you are horror under a pin with not dead cells taken off piece by piece a stream of un-consciousness good for nothing but self-cannibalizing desperate for something to fill your detritus a hate for something you can't name" "a you that do not" "are not")
("sometimes you see people they forget that they are people. sometimes that is for the best.")
[break]
Addendum-120320B: Itamura submitted for performance review after mission. Agent demonstrated certain lack of discipline in carrying out the mission and was influenced easily by trainee's provocations. Additional psychological eval recommended along side with physical therapy.
Incident log C133-120320: You cannot forget how bone feels between teeth.
("something hungers in the woods somewhere and it always finds you among the trees." This sentence repeats in the background, going off the margin.)
Department of Training. 21/02/(redacted)
("you had bunny teeth. you remember
someone
calling you
puppy
though.")
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jobyoda-philippines · 5 months ago
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Exploring Career and Job Opportunities in Davao City Philippines
Davao City, recognized as one of the Philippines' most progressive cities, continues to experience remarkable economic growth, creating a vibrant job market that attracts professionals from across the country. The city's diverse economy offers numerous employment opportunities, from entry-level positions to executive roles, making it an attractive destination for job seekers at all career stages.
The Business Process Outsourcing (BPO) sector stands as one of the largest employers in Davao City, providing thousands of jobs across various specializations. Companies in this sector actively recruit customer service representatives, technical support specialists, and quality assurance analysts, offering competitive salaries and comprehensive benefits packages. The industry's continued expansion has created numerous opportunities for career advancement, with many organizations promoting from within and providing extensive training programs.
Part-time employment opportunities have also flourished in Davao City, catering to students, professionals seeking additional income, and individuals preferring flexible work arrangements. The retail sector, food service industry, and education field offer numerous part-time positions with varying schedules and responsibilities. These roles often provide valuable work experience and can serve as stepping stones to full-time careers.
The Information Technology sector in Davao has seen significant growth, with many companies seeking software developers, web designers, and IT support specialists. This growth has been fueled by the city's improving technological infrastructure and the increasing number of tech-focused businesses establishing operations in the region. Tech professionals can find opportunities in both established companies and startups, with many positions offering competitive compensation and the possibility of remote work arrangements.
Davao's hospitality and tourism industry continues to expand, creating jobs in hotels, restaurants, travel agencies, and tour operations. The sector offers positions ranging from entry-level service roles to management positions, with many employers providing training and development opportunities. The industry's growth has also sparked demand for professionals in events management and tourism marketing.
The education sector presents numerous opportunities for both full-time and part-time employment. Educational institutions regularly seek teachers, tutors, and administrative staff. The rise of online learning has created additional opportunities for English language teachers and academic consultants who can work flexible hours from home or teaching centers.
Job hiring  in Davao, the digital economy has opened new avenues for employment. E-commerce specialists, digital content creators, and social media managers are in high demand as businesses increasingly establish their online presence. These positions often offer the flexibility of remote work while providing competitive compensation packages.
Professional development resources are readily available in Davao City, with numerous institutions offering skills training programs and industry certifications. Job seekers can access career counseling services, resume writing assistance, and interview coaching through various employment support organizations. These resources prove invaluable in helping candidates prepare for and secure desired positions.
The financial services sector in Davao has also experienced substantial growth, creating opportunities for banking professionals, insurance specialists, and investment consultants. These positions typically offer attractive compensation packages, including performance bonuses and health benefits, making them highly sought after by experienced professionals.
Davao's agricultural sector continues to evolve, combining traditional farming with modern agribusiness practices. This has created opportunities for agricultural technologists, food processing specialists, and supply chain professionals. The sector offers both technical and management positions, with many companies providing specialized training and development programs.
For those entering Davao's job market, proper preparation is essential. Successful job seekers typically maintain updated resumes, prepare comprehensive portfolios, and stay informed about industry developments. Professional networking, both online and offline, plays a crucial role in discovering opportunities and advancing careers in the city.
The future of Davao's job market looks promising, with emerging industries creating new employment opportunities. The city's commitment to economic development, coupled with its strategic location and robust infrastructure, continues to attract businesses and investors, ensuring a steady stream of job opportunities for qualified candidates.
Whether seeking full-time employment or part-time job in Davao City offers a diverse range of opportunities across multiple industries. Success in this dynamic job market often comes to those who combine proper preparation with continuous skill development and effective networking. As the city continues to grow and evolve, its job market remains a beacon of opportunity for professionals seeking to build meaningful careers in Mindanao's premier business hub.
#Davao City#recognized as one of the Philippines' most progressive cities#continues to experience remarkable economic growth#creating a vibrant job market that attracts professionals from across the country. The city's diverse economy offers numerous employment op#from entry-level positions to executive roles#making it an attractive destination for job seekers at all career stages.#The Business Process Outsourcing (BPO) sector stands as one of the largest employers in Davao City#providing thousands of jobs across various specializations. Companies in this sector actively recruit customer service representatives#technical support specialists#and quality assurance analysts#offering competitive salaries and comprehensive benefits packages. The industry's continued expansion has created numerous opportunities fo#with many organizations promoting from within and providing extensive training programs.#Part-time employment opportunities have also flourished in Davao City#catering to students#professionals seeking additional income#and individuals preferring flexible work arrangements. The retail sector#food service industry#and education field offer numerous part-time positions with varying schedules and responsibilities. These roles often provide valuable work#The Information Technology sector in Davao has seen significant growth#with many companies seeking software developers#web designers#and IT support specialists. This growth has been fueled by the city's improving technological infrastructure and the increasing number of t#with many positions offering competitive compensation and the possibility of remote work arrangements.#Davao's hospitality and tourism industry continues to expand#creating jobs in hotels#restaurants#travel agencies#and tour operations. The sector offers positions ranging from entry-level service roles to management positions#with many employers providing training and development opportunities. The industry's growth has also sparked demand for professionals in ev#The education sector presents numerous opportunities for both full-time and part-time employment. Educational institutions regularly seek t
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dead-generations · 28 days ago
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I think it's funny that the tech CEO idea of having generalists who master working from first principles to solve any problem in any sector which you can deploy rapidly was kinda pioneered by communists.
"guy with a mastery of first principles and discipline who will analyse any problem in any field and solve it" was the main program of the pre-USSR Bolsheviks and Mao era Chinese communists. Mao and Lenin both wrote books about how important this type of guy is. They used this type of guy to bootstrap navies and air forces.
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corellianhounds · 2 months ago
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Me writing what should have been at most a bullet point one-shot comedic romance adventure: “hee hee hoo I’ll knock this out in no time”
Me, four months later and 112k+ words in: “Hmm I think I need to look at the practical engineering reference guide again so we can really assess the recycler issue on this cistern in the compound because I don’t know that they could have it on the lower level if the mountain rock is going to have a level 9 on the Mohs hardness scale—”
#Cannot stress enough how very little any of this research actually gets put into the fic itself#I just need for any technical/sci-fi details I include to sound somewhat believable even if they’re only mentioned in passing#Most of these conflicts are based on their environment so it has to have some measure of truth at the center#It’s like how you can tell when a book centered around nature or agriculture has been written by somebody who didn’t actually grow up aroun#either of those things and obviously hasn’t done their research to the point their characters know what they’re talking about#Anyway yeah. The soldiers need to seem competent at fixing their equipment and improvising tools based on the vast amount of training#and education they were given#Which means I as the author need to understand the problem the complications AND THE SOLUTION well enough the characters sound#not just knowledgeable but natural and familiar with it when talking about it#Same goes for the pilot. I’m pulling out my old flight manuals and looking into advanced avionics just so I can consolidate#a simplified answer into two sentences she can use to explain her area of expertise to somebody who has no idea what kind of ship she flies#Anyway#Fic: Call Sign#The actual simple reason for doing this is that effective imagery and worldbuilding fills out the world and makes it richer as a result#And unfortunately that means I am doing several crash courses in about fifteen different sciences so that I know what I’m talking about#Fun fact I wanted to be a cargo pilot but the aviation program at my university was THE most expensive major they had#And I’m not good/fast enough at math to get through even the small aircraft piloting guide 😞#If I can’t have the adventures and experiences I want I can at least tell stories where they happen#The good news is I have had plenty of experience fixing things and improvising technical solutions based on what science and history I know#So many of these problems are just household and vehicle issues on a bigger scale
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ask-the-devils-bastard · 3 months ago
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Well to be honest I quite like the sound of your voice too! I find the radio filter over it very soothing to listen to. (Genuine compliment. Take it or not)
Sooo if you want you can yap about anything ya want :D
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Alastor: As well you should! I did spend a great deal of time perfecting it.
Alastor: Anything I like, him? Well that is quite a broad range of topics. Your compatriot seemed rather interested in learning more about my preferred medium. I could educate you on its technical aspects, or go over the history. Perhaps you'd like to hear about New Orleans' very first radio station, hm?
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akshayroy123 · 2 years ago
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What is Time Complexity And Why Is It Essential?
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In the world of computer science and algorithms, there is a crucial concept that reigns supreme when it comes to evaluating the efficiency of algorithms: time complexity. Time complexity is the measure of how an algorithm's execution time grows with respect to the size of its input data. It is essential because it allows us to compare and analyze different algorithms' performance objectively. In this article, we will delve into the concept of time complexity, its significance, and why it is essential in the field of computer science. So, let’s get started with some Technical Training Program ahead.
Understanding Time Complexity
Time complexity is a fundamental concept in computer science that helps us quantify the amount of time an algorithm takes to run as a function of the input size. It provides us with a clear and systematic way to analyze and compare the efficiency of algorithms. Time complexity is typically expressed using big O notation, which describes the upper bound of an algorithm's running time concerning its input size. For instance, O(n) represents linear time complexity, indicating that an algorithm's execution time grows linearly with the size of the input.
Importance of Time Complexity
Algorithm Selection:
Time complexity is essential for choosing the most suitable algorithm for a specific task. When faced with multiple algorithms to solve a problem, analyzing their time complexities helps us select the one that will perform the best in practice, thanks to Technical Transformation and evolution. An algorithm with a lower time complexity is more efficient and preferable.
Resource Allocation:
In many real-world applications, computational resources like CPU time and memory are limited. Time complexity guides us in making informed decisions about resource allocation. Algorithms with low time complexity are preferred in resource-constrained environments, ensuring that the system operates efficiently.
Scalability:
As the volume of data processed by computers continues to grow, scalability becomes a critical concern. Time complexity helps us assess how well an algorithm can oversee larger datasets. Algorithms with lower time complexity are more scalable, making them suitable for big data applications.
Optimization:
Time complexity analysis is a vital tool in optimizing algorithms. By identifying bottlenecks and inefficiencies in an algorithm's code, developers can work to improve its performance. This process often involves reducing time complexity, resulting in faster and more efficient algorithms.
Predictability:
Time complexity allows us to predict an algorithm's behavior under different conditions. It helps us estimate how long an algorithm will take to execute, making it valuable for designing real-time systems and meeting performance requirements followed by in-depth Technical Learning.
Real-World Applications
Time complexity is not just an abstract concept; it plays a crucial role in various real-world applications:
Search Engines:
Search engines like Google process enormous amounts of data in real-time which is a perk of the evolving Technical Transformation. The algorithms used for ranking and retrieving search results rely on efficient data structures and algorithms with low time complexity to deliver fast and relevant results.
E-commerce:
Online shopping platforms use algorithms to recommend products to users based on their browsing and purchase history. These recommendation algorithms must process vast datasets efficiently, making time complexity analysis indispensable.
Financial Trading:
High-frequency trading systems execute thousands of trades per second. Time complexity is vital for optimizing trading algorithms to gain a competitive edge in the financial markets. Relevant Technical Training Courses can give us more knowledge of this.
Healthcare:
Medical imaging and diagnostic algorithms must process and analyze large datasets, often in time-critical situations. Low time complexity is essential for providing timely and accurate results.
Final Words
Time complexity is a fundamental concept in computer science that enables us to evaluate and compare the efficiency of algorithms. It plays a crucial role in algorithm selection, resource allocation, scalability, optimization, and predictability. In a world where computational power is at the heart of technological advancements, understanding and leveraging time complexity is essential for designing and implementing efficient algorithms that drive innovation and solve complex problems.
Moreover, relevant Technical Training Courses should also be made available for employees to enhance their skills and efficiency. As technology continues to evolve, the significance of highly skilled employees in the workplace along with time complexity in the field of computer science remains unwavering, making it a cornerstone of algorithmic efficiency.
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cacowhistle · 9 months ago
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thinkin abt going back to my roots (writing pokemon oc fanfiction) except this time instead of fantasy adventures like when i was 12 it's the joys of the mundane and also way too much thought about worldbuilding
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pttiedu · 2 years ago
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Markus Ellis, a recent graduate who is making a mark in this world - PTTI Student
Emerging triumphantly from the realm of manufacturing is our accomplished student, Markus Ellis, a recent graduate who is making a mark in this world.
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pttedu · 18 days ago
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At Philadelphia Technician Training Institute, we’re shaping the next generation of skilled professionals with hands-on training and real-world experience.
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whyisablog · 21 days ago
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You know how in gym class they would ask you to do a push up and if you couldn't do it, maybe you've never done a push up in your entire life, they would judge you instead of teaching you how to do it correctly so you dont hurt yourself?
Thats what on the job training feels like nowadays.
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projectiononline · 1 month ago
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You’re moments away from learning how to create powerful digital campaigns to drive relevant traffic to your website or business.
Get Our Advanced Digital Marketing Course The Ultimate Digital Marketing Course Our comprehensive, hands-on digital marketing training program can help you with all aspects of digital marketing and everyone who wants to become a successful online marketer, grow in their career or in their business. This course includes SEO (On-Page, Off-Page and Dynamic SEO), Social Media Marketing & Optimization, Advanced Content Marketing, Google Analytics (with Certification), Google Webmaster Tools, Email/SMS Marketing, Google AdSense & AdWords Setup, Affiliate Marketing.
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technicalinstitute · 3 months ago
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Top Nursing Courses Offered by Leading Nursing Institutes in Kolkata
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Kolkata has become a prominent center for nursing education, offering a variety of courses to aspiring healthcare professionals. A well-structured nursing program equips students with the knowledge and skills required to provide excellent patient care. If you are looking for the best Nursing Institute in Kolkata, understanding the top courses available is crucial to making an informed decision.
Auxiliary Nursing Midwifery (ANM)
The ANM course is a two-year diploma program designed for students who wish to enter the healthcare sector quickly. It focuses on basic nursing care, maternal and child health, and community health services. This course is ideal for individuals passionate about serving in rural healthcare settings and primary healthcare centers.
General Nursing and Midwifery (GNM)
GNM is a three-year diploma program that provides in-depth knowledge of nursing, midwifery, and medical-surgical nursing. Students enrolled in this course at a reputed Nursing Institute in Kolkata gain hands-on training in hospitals and clinics, preparing them for real-world healthcare challenges. Global Technical Institute offers GNM courses with excellent training facilities and internship opportunities in reputed hospitals. Name: Global Technical Institute- Nursing Training Institute in Kolkata Address: 17A, Hara Mohan Ghosh Ln, Phool Bagan, Beleghata, Kolkata, West Bengal 700085 Phone Number: 8961008489
Map:https://maps.app.goo.gl/VyF5RAtbfGRj5Lv77
Bachelor of Science in Nursing (B.Sc Nursing)
The B.Sc Nursing program is a four-year undergraduate course that focuses on theoretical and practical nursing education. It covers subjects like anatomy, physiology, pharmacology, and critical care nursing. This course is ideal for students who aspire to work as registered nurses in hospitals, clinics, and research institutions. Global Technical Institute provides a comprehensive B.Sc Nursing program with modern infrastructure and expert faculty.
Post Basic B.Sc Nursing
This course is designed for diploma holders in nursing who wish to upgrade their qualifications. It is a two-year program that enhances knowledge and clinical skills, making nurses eligible for senior roles in hospitals and healthcare facilities. A top Nursing Institute in Kolkata like Global Technical Institute offers this course with a focus on advanced patient care and hospital management.
Master of Science in Nursing (M.Sc Nursing)
For those looking to specialize further, an M.Sc Nursing program is an excellent option. This two-year postgraduate course offers specialization in areas like pediatric nursing, psychiatric nursing, and critical care nursing. Graduates of this program can pursue leadership roles in hospitals, academics, and research fields.
Conclusion
Choosing the right Nursing Institute in Kolkata is crucial for building a successful career in the healthcare sector. Global Technical Institute offers high-quality nursing education with top-notch faculty, advanced training, and excellent placement opportunities. Whether you are starting with an ANM diploma or aiming for an M.Sc in Nursing, the right institute can shape your future in the medical field.
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foldingfittedsheets · 1 year ago
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Mattresses, unbeknownst to many, are a lot like cars. Every year new ones roll out, they’re always tweaking and innovating and you’ll never find the same one you loved decades ago when buying a new one.
Where I sold mattresses had a three month return or exchange program for this reason. New beds take a while to break in, and they’re a big expense. Your body is used to the old one. So we made sure people were loving it. If a bed got returned we’d take it back, sanitize and clean it, then sell it again on clearance.
To sell these we always had to disclose what clearance meant to customers, and they had to sign that they knew what they were getting. (FYI, not every company is as… forthright about the used bed situation)
In clearance we had beds that were floor models, we had returns, and more rarely we had old models whose line had been discontinued. These clearance beds were always final sale, so a bed could only be sold twice.
Now, the manager at the store I was working at had realized a vital fact. Clearance beds in the warehouse didn’t sell, especially old models that salespeople weren’t familiar with. And even more especially in odd sizes, like twin extra longs. So he set up a split king on the showroom floor to exhibit clearance beds, pulling all those forgotten twin extra longs out onto the showroom.
Almost all of these were brand new discontinued models. Beds I’d never learned in training were exhumed to be displayed. The manufacturers had moved on to new lines and they’d been left behind. Why would he take such in interest in selling old stock, you might wonder? Because we made double commission on the sales margin of clearance beds, and if we’d had a bed long enough they dropped the cost in the system so it was a fucking cash cow to sell these. Even with huge discounts the commissions were wonderful so it was a win win.
When I got started I was jazzed about this program, I was so on board to sell weird old brand new beds and make a ton of money. I had a wonderful older couple come in, looking for a split king adjustable set. This was a white whale sale.
The current clearance models on the floor were a latex mattress that was brand new despite being of an age to start first grade, and a tempurpedic floor model. The couple laid down and it was like magic. They each loved the bed they’d laid down on. They wanted to buy the whole shebang.
I. Was. Thrilled. I told them about the clearance program and what that meant, and they weren’t bothered in the least. I wrote up the sale then dashed into the back, fizzing with excitement to tell my manager what I’d done.
“You sold the death bed?!” He asked in delight.
I pulled up short, my smile freezing in place. “What…?”
“Didn’t you check the notes?”
I hesitated for a long beat then slowly shook my head. You see, dear reader, all beds had a personal history. Every clearance bed had logs written up by the person who took the return, as well as warehouse crew after sanitizing. It helped us know what to expect when selling them. “Wasn’t it just a floor model? You said it was a floor model…”
He slowly shook his head. I checked the notes.
It turned out, it had been sold as a floor model. The first time. But the company had made an exception and taken it back as a return two months later. Why? Because it’s owner had passed away.
I stared at the computer in horror and my manager shrugged. “They signed the clearance form. Technically it was a floor model.”
“We know for a fact that a man died in that bed!”
“What they don’t know can’t haunt them,” he said philosophically.
The man came back a week later for more sheets, utterly delighted to tell me how well they were sleeping. I clamped my teeth down around the secret of the deathbed, choosing to let them love their new bed without the stigma. Only one person would be haunted by that deathbed, and it was me.
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reasonsforhope · 10 months ago
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"The first modern attempt at transferring a uterus from one human to another occurred at the turn of the millennium. But surgeons had to remove the organ, which had become necrotic, 99 days later. The first successful transplant was performed in 2011 — but even then, the recipient wasn’t immediately able to get pregnant and deliver a baby. It took three more years for the first person in the world with a transplanted uterus to give birth. 
More than 70 such babies have been born globally in the decade since. “It’s a complete new world,” said Giuliano Testa, chief of abdominal transplant at Baylor University Medical Center.
Almost a third of those babies — 22 and counting — have been born in Dallas at Baylor. On Thursday, Testa and his team published a major cohort study in��JAMA analyzing the results from the program’s first 20 patients. All women were of reproductive age and had no uterus (most having been born without one), but had at least one functioning ovary. Most of the uteri came from living donors, but two came from deceased donors.
Fourteen women had successful transplants, all of whom were able to have at least one baby.  
“That success rate is extraordinary, and I want that to get out there,” said Liza Johannesson, the medical director of uterus transplants at Baylor, who works with Testa and co-authored the study. “We want this to be an option for all women out there that need it.”
Six patients had transplant failures, all within two weeks of the procedure. Part of the problem may have been a learning curve: The study initially included only 10 patients, and five of the six with failed transplants were in that first group. These were “technical” failures, Testa said, involving aspects of the surgery such as how surgeons connected the organ’s blood vessels, what material was used for sutures, and selecting a uterus that would work well in a transplant. 
The team saw only one transplant fail in the second group of 10 people, the researchers said. All 20 transplants took place between September 2016 and August 2019.
Only one other cohort study has previously been published on uterus transplants, in 2022. A Swedish team, which included Johannesson before she moved to Baylor, performed seven successful transplants out of nine attempts. Six women, including the first transplant recipient to ever deliver a baby back in 2014, gave birth.
“It’s hard to extract data from that, because they were the first ones that did it,” Johannesson said. “This is the first time we can actually see the safety and efficacy of this procedure properly.”
So far, the signs are good: High success rates for transplants and live births, safe and healthy children so far, and early signs that immunosuppressants — typically given to transplant recipients so their bodies don’t reject the new organ — may not cause long-term harm, the researchers said. (The uterine transplants are removed after recipients no longer need them to deliver children.) And the Baylor team has figured out how to identify the right uterus for transfer: It should be from a donor who has had a baby before, is premenopausal, and, of course, who matches the blood type of the recipient, Testa said...
“They’ve really embraced the idea of practicing improvement as you go along, to understand how to make this safer or more effective. And that’s reflected in the results,” said Jessica Walter, an assistant professor of reproductive endocrinology and infertility at Northwestern University Feinberg School of Medicine, who co-authored an editorial on the research in JAMA...
Walter was a skeptic herself when she first learned about uterine transplants. The procedure seemed invasive and complicated. But she did her fellowship training at Penn Medicine, home to one of just four programs in the U.S. doing uterine transplants. 
“The firsts — the first time the patient received a transplant, the first time she got her period after the transplant, the positive pregnancy test,” Walter said. “Immersing myself in the science, the patients, the practitioners, and researchers — it really changed my opinion that this is science, and this is an innovation like anything else.” ...
Many transgender women are hopeful that uterine transplants might someday be available for them, but it’s likely a far-off possibility. Scientists need to rewind and do animal studies on how a uterus might fare in a different “hormonal milieu” before doing any clinical trials of the procedure with trans people, Wagner said.
Among cisgender women, more long-term research is still needed on the donors, recipients, and the children they have, experts said.
“We want other centers to start up,” Johannesson said. “Our main goal is to publish all of our data, as much as we can.”"
-via Stat, August 16, 2024
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