#acutelymphoblasticleukemia

[cytgen]

Abstract Cytogenetic rearrangements were studied in bone marrow cells of 24 patients with relapse of acute lymphoblastic leukemia (ALL). The authors have noted a high percentage of mosaic karyotypes (75.0%) with a predominance of abnormal clones combined with normal karyotypes (33.3%). Trisomies of chromosomes led to the formation of hyperdiploid clones, among which trisomies of chromosomes 6, 21, 15, and 5 were the most frequent events. Additional marker chromosomes were recorded in 22.2%. To characterize the mechanisms underlying the abnormal clone formation in relapse of ALL, structural chromosomal anomalies were recorded and divided into balanced (translocations, inversions) and imbalanced (deletions, isochromosomes, additional material of unknown origin, duplications, and imbalanced translocations) abnormalities. Losses of genetic material (deletions) (24.1%) and translocations (33.3%) were most frequently detected. The total number of events with translocation t(9;22)(q34;q11.2) reached 20.4%. The evolution of clonal chromosomal abnormalities occurred due to the emergence of additional numerical and imbalanced structural abnormalities. The comparison between chromosome abnormalities at diagnosis and in relapse of B-cell ALL has not led to any general mechanisms for the formation of chemotherapy-resistant clones. Trisomy of chromosome 5, deletion del(6)(q23), and translocation t(9;22) (q34;q11.2) were involved in the formation of chemotherapy-insensitive clones. The group of unfavorable prognosis included 95.8% of karyotypes.

[thxnews]

Novel Agents Target Tough Cancers at AACR

In the splendid city of Rome, on this brisk April morning, the halls of innovation buzz with anticipation. IRBM, a beacon in the drug discovery domain, proudly announced its intent to unveil groundbreaking data on its latest cancer-fighting warriors at the AACR Annual Meeting in sunny San Diego. As we stand on the cusp of these revelations, let's delve into the essence of these promising agents against the backdrop of IRBM's legacy of innovation.   A Leap Forward in Cancer Treatment The journey of IRBM, marked by relentless pursuit and scientific prowess, brings us two novel compounds poised to redefine cancer therapy. The first, an antibody-drug conjugate (ADC) targeting CRLF2/TLSPR in "Ph-like" B-ALL, emerges as a beacon of hope for hematologic cancer, notorious for its grim prognosis. This potential first-in-class ADC, AM E3-SG3249, has demonstrated significant preclinical efficacy, heralding a new era in treating a cancer most prevalent among adolescents. On another frontier, the potential best-in-class brain permeable SHP2 allosteric inhibitor, I-1000233, showcases promising results against RAS-driven malignancies, including the formidable foes of brain tumors and metastases. This innovative approach not only pierces the veil of brain tumor treatment but also promises a new dawn for patients ensnared by these aggressive cancers.   Unveiling IRBM's Vision Carlo Toniatti, the esteemed Chief Scientific Officer of IRBM, shared his exhilaration about the forthcoming presentations. "The AACR meeting, is a golden opportunity for IRBM to parade our latest strides in cancer research." This sentiment encapsulates IRBM's dedication to carving new paths in therapeutic strategies, aiming to lighten the burden on those battling cancer. IRBM's integrated research capabilities, fostered within the synergistic environment of the National Collection of Chemical Compounds and Screening Center (CNCCS), underscore the organization's commitment to science that betters lives. These assets, advanced through discovery phases with a blend of public and private zeal, are testaments to IRBM's role as a pioneer in drug discovery.   Spotlight on Innovation The AACR meeting will serve as the stage for detailed presentations on these innovative assets. Francesca Puca, PhD, and Claudia Dall'Armi, PhD, will be presenting their findings on the CNS-penetrant SHP2 inhibitor and the CRLF2/TLSPR targeting ADC, respectively. These sessions promise to be a deep dive into the science that could shift paradigms in cancer treatment.   The Essence of IRBM IRBM stands as a titan in drug discovery, harmonizing decades of expertise with a fervent drive for innovation. With contributions to four approved drugs and a robust internal pipeline, IRBM exemplifies the power of deep collaboration in pushing the boundaries of what's possible in medicine. The partnership with CNCCS enhances IRBM's ability to spearhead discoveries in cancer treatment, among other therapeutic areas. This collaboration is a shining example of how public-private endeavors can fuel translational research, bringing us closer to solutions for some of the most challenging health issues of our time.   What It Means As we eagerly await the revelations from IRBM at the AACR Annual Meeting, let us reflect on the journey of discovery and the promise it holds. In the quest to conquer cancer, every step forward is a beacon of hope. IRBM's novel preclinical agents against aggressive brain tumors and acute lymphoblastic leukemia are not just scientific advancements; they are harbingers of new beginnings for patients worldwide. With the spirit of exploration and the promise of tomorrow, we stand on the brink of a new era in cancer treatment, inspired by the tireless efforts of researchers and visionaries at IRBM. Here's to the dawn of new possibilities, the triumph of science, and the relentless pursuit of a cancer-free world.   Sources: THX News & IRBM S.p.A.. Read the full article

[padansk]

Happy ‘unofficial’ Birthday @nrmakin. It’s 5 years ago today that my wife had a lifesaving blood Stemcell transplant at The Christie hospital in Manchester. I’ll be eternally grateful to those involved in making that happen. It’s not been the easiest of times since then, but as a husband and wife we are made of the strongest stuff. #birthday #stemcelltransplant #acutelymphoblasticleukemia #thechristie #dkms #amour (at Newborough Beach, Anglessey) https://www.instagram.com/p/CL6UgzNlIKv/?igshid=4gtcdnmbdnry

[technodesignmasters]

Only a few days left please help this wonderful women with anything you can small donations accepted on site aswell let's show our Strength for Sarah https://www.customink.com/fundraising/strength-for-sarah #acutelymphoblasticleukemia #StrenghtForSarah #donate #showyoursupport #BeKind #womenempowerment #share #donate #donatetoday #showlove (at Little Falls, Minnesota) https://www.instagram.com/p/CGhQbSwBYKu/?igshid=xuidfbdl323q

[jessicaorona]

Hi! I want to make a chit chat GRWM on sunday! If you guys have any questions regarding my cancer treatment or diagnosis please let me know! I'd love to discuss 😇

[bilogyuniverse]

More hematology! 😁

[marcyvabroad]

Your Burden Gives You Wings

3.25.19

As I walk a new path - both literally and figuratively - I find myself lost in thought. I have done it! I have sparked the age of self-actualization by pulling the trigger and moving out on my own. Inevitably, new concerns arise as my brain struggles to sit in it’s own contentment and finds a way to create new problems to occupy itself.

I find myself experiencing a sense of responsibility towards my past, well, maybe not my past but to those experiencing what my past self went through. I feel responsible for going back down the mountain of self-actualization (not that I, by any means, have peaked) to offer a hand to those in the trench. I did not ask for cancer, or for any other trauma in my life, and for years now I have resented it. Sure, sure, I am 100% honest when I say I am glad to have grown from my pain, and learned that you have to lean into it to heal it. Oddly, I’m glad to have had my terrible experiences because they make me better at what I do, and make it easier for me to relate to anyone. Everyone wants to be heard, and to have someone say that they do not judge them for thinking, saying, or doing terrible things as a result of their own horrific histories. I feel my experience has given me the opportunity to truly understand the pain of others. Or, at least recognize that I cannot understand their pain but know what it means to need to be heard so that someone else can feel this burden you carry.

So now, I feel that I must lend myself to the support of young adults struggling with cancer. This was recently sparked by a conversation I had with my sister, who is a nurse on a post-op floor for joint replacements. She told me she treated a client who was a young adult who had her hip replaced after complications from ALL - just like me. She was able to use my story to relate to the family, and as it turns out, they had already heard of me! The oncology team had already told the girl that there was another patient of theirs who had two hip replacements, and was out there living her best life, even after all she went through. It turns out, I had been a source of ease for this family, a reassurance that despite how scary this young woman’s circumstances have been, you can come out the other side and be whole. The mother of this woman begged my sister for details, “Did she really go to grad school despite chemo-brain? Is there a chance that chemo brain won’t limit my daughter’s ability to continue to progress in life?” “She lives a ‘normal’ life now?”

I don’t say this all to toot my own horn, but I did feel a million feels when I heard this story. I was reminded of how grateful I should be that I survived at all. That I was able to go to graduate school, get a job, have relationships. That I had my hips replaced and still rock a bikini, hike mountains, and do yoga. I was also thrust back into the pain of the past. Reminded of a time when I had little hope, was unsure what to look forward to, convinced that any sort of “normalcy” was off the table and I was plagued for life. In a way, I am still plagued by the haunting feeling that relapse could be around any corner. But I don’t live my life like that anymore - in desperate search of hope, solace from my pain, a person to understand the infinitely gut-deep horror that can haunt my thoughts at the slightest sense of lethargy.

Which is why I now feel responsible. To pick back up, to keep sharing my story even though I want nothing more than for some sort of “obliviate” charm to erase my memories of such a dark time in my life. I feel responsible to share that despite years of my life being dedicated to hospitals, the scent of saline, to slowly figuring out what the fuck to do with my hair, I am now as un-sarcastically as I can put this, living my best life.

I chose to heal myself, which was not easy. And I am not, by any means, all healed. But I am at peace with how my life is now. I fought through occasionally throwing up in the office trash can, awkward conversations on first dates about ports and battle scars, through bouts of forgetfulness, self-doubt, and depression. I sought out help through my therapist, who I am not ashamed to say I have been seeing for 3 ½ years now. I pruned my friends down to those who didn’t mind my limited mobility for months on end, dumped partners who didn’t empower me, and learned to set boundaries with others as well as myself in order to make every shred of this life as “worth it” as I can make it. Because I have lost friends to this disease. Because I know this life could be stolen back at any moment. I choose to find ways to make this life bearable, and I want to share that with anyone who cares to hear it.

[anjrawat]

CAR-T Cell Therapy Market In Acute Lymphoblastic Leukemia (ALL)

Acute lymphocytic leukemia (ALL) is a tumor that afflicts bone marrow and hampers the production of healthy White blood cells. ALL is acute cancer denoting its rapid progression, if not treated can be fatal within a few months.

DelveInsight estimates by 2030, the Car-T cell therapy market in Acute lymphoblastic leukaemia would approximate to USD 1,315.7 million in the 6MM (U.S. and EU5 including UK, Germany, Italy, France and Spain), emerging as a multi-billion-dollar industry.

MB-CART19.1, PBCAR0191, AUTO3 are some of the emerging therapies in Acute Lymphoblastic Leukemia market. The Acute Lymphoblastic Leukemia market consists of the big pharma players as well as the mid-sized companies, hence is moderately competitive. Some of the leading companies in Acute Lymphoblastic Leukemia market includes Miltenyi Biotec, Precision BioSciences, Autolus Limited. 

For more details visit: https://www.delveinsight.com/blog/car-t-cell-therapy-market-in-acute-lymphocytic-leukemia/

[thebikerbookforcharity]

#raleigh #northcarolina - May 7

#motorcycles #charity #charityevent #fundraiser #motorcycle

#acutelymphoblasticleukemia #leukemia

#thebikerbookforcharity

[technodesignmasters]

Only a few days left please help this wonderful women with anything you can small donations accepted on site aswell let's show our strength for Sarah

https://www.customink.com/fundraising/strength-for-sarah

#acutelymphoblasticleukemia #StrenghtForSarah #TechnoDesignMasters

[thecaregiverspace]

Managed to get off the couch and play. William tried to include his paw patrol cars...didn't go down well. Missing school, bored and hungry. #childhoodleukemia #bloodcancer #cancersucks #childhoodcancer #facesofcare #acutelymphoblasticleukemia 📷: @ollivianancekivell https://ift.tt/2oSuxTn

[yuriwangfingermedia]

與命運拔河的「白血病」小生命　後線化療幫他們拔贏命運

(健康醫療網／編輯部整理)

急性淋巴性白血病（Acutelymphoblasticleukemia，簡稱ALL）是台灣常見的兒童癌症，這些病童往往在很小的時候就發病，還好有八成的病患可以透過治療得以緩解；但對長年在治療這些病童的醫師來說，看到每個與命運拔河的小生命，總是感觸特別深。

新生兒腹部異常腫大、白血球高達四、五十萬　竟患急性淋巴性白血病

「我印象最深刻的是一個剛出生沒幾天的新生兒，爸媽覺得他肚子大的有些不尋常，送到住家附近的醫院檢查，竟發現血中白血球數目高達四、五十萬（正常為五千到一萬），經確診是急性淋巴性白血病後，就趕緊轉院到我們這邊來治療。」令台中榮總兒童血液腫瘤科主任張德高這麼訝異的原因是，這位病童疾病的惡性度令人瞠目結舌。

「住院後有一次我們幫他檢驗，結果血中白血球數目竟然高達百萬，這代表整個身體幾乎都是癌細胞了！」這樣的結果也差點讓檢驗儀器損壞；後來經過醫療團隊的檢查，…

[marcyvabroad]

WTF

I was scheduled to get steroid injections in my hips today to relieve my pain. The pain that has kept me from having a full night of undisturbed sleep for over a year. The pain that makes me use my arms more than my legs to climb a flight of stairs. The pain that makes me enviously look at everyone's legs as they walk around, not realizing how lucky they are that they don't even think about it. I took a half day at work, having to ask a coworker to cover an appointment for me in order for me to get this procedure. I hobbled into the orthopedic oncology office, nervous but ultimately excited to finally have some relief.

Only to find that they don't do steroid injections in hips at the office that scheduled me. The front desk staff  who scheduled me had assured me this procedure was "not a big deal" and "they do it all the time". I was sent home immediately because they could not complete the procedure due to a lack of the appropriate equipment. 

Now, I know no one in that office knows what is going on in my life right now. They do not know that even going into this appointment today I was in a bad place. But I can’t help but feel extremely angry with how all of this went down. 

How could I have been scheduled if they don’t even do that procedure in that office? How did no one catch this until the day/moment of the appointment? And given that they work almost exclusively with cancer patients, how were they clearly not provided with any sensitivity training?

Also, Universe, I THINK I HAVE LEARNED MY LESSON THAT LIFE IS UNFAIR. YOU CAN STOP AT ANY TIME NOW. 

[curveegurl73-blog]

‪My mom is a #chemopatient and got #bronchitis For weeks, she's been #coughing She used this three times, and her #cough is almost gone. https://www.etsy.com/listing/515014587/holistic-cough-relief-essential-oil‬ #healing #autogramtags #meditation #innerpeace #meditate #energyhealing #selfhealing #chakras #lightworker #Chemo #cancerwalk #cancerfighter #cancersurvivors #lungcancerawareness #cancerfree #acutelymphoblasticleukemia #stomachcancer #Holistic #holistichealth #holisticliving #naturalhealth #naturalhealing #holistichealing #holisticnutrition #holisticlifestyle #healthandwellness #smallbusiness #smallbiz #smallbusinesslove #supportsmallbusinesses (at Kimberly, Wisconsin)