#clinical trail

[crimsonpublishers-oabb]

Managing Pandemic Disasters: A Resource-Based Analysis

Healthcare crises are well-known phenomena that occur and are highly disruptive. Consider, for example, Covid19 and other pandemics, wars, multi-casualty natural disasters, industrial disasters, etc. Healthcare systems in Brazil, Spain, Italy, and more around the world collapsed due to the lack of a clear methodology for handling such crises. Following a largescale value creation project with a large medical center we developed a resource-based methodology to cope with three healthcare crisis scenarios: “Peace”, “War” and “Tsunami”.

We identified three load/capacity scenarios for hospitals: “Peace”, “War” and “Tsunami”. The Peacetime scenario is the normal overload situation in a hospital. Figure 1 during “Peace” times, hospitals are usually 10%-20% short in resources. To overcome bottlenecks, managers apply evolutionary methods such as constraint management [1], the complete kit concept, etc. This is the normal condition in hospitals where there are fluctuations in supply and demand. Bottlenecks in this situation are typically medical crews: senior physicians and experienced nurses.

Read More About This Article: https://crimsonpublishers.com/oabb/fulltext/OABB.000567.php

Read More About Crimson Publishers: https://crimsonpublishers.com/oabb/index.php

[sollers-college]

Students can discover many prospects by enrolling in a clinical trial management program, which provides a special combination of theoretical knowledge and practical abilities.

[defrostedvertebrae]

Hares on trail cams look ethereal

[toiletwipes]

Whenever I'm Alone (With You) | clinic!wilbur

MOUTH SO SWEETLY TELLING LIES — PART TWO

5k words. / [Two months after the festival you're left in the dust of what to do with yourself when you've been ghosted by a really cute guy. Depression hits and it's not a good mix.] [watch out for self-deprecation, slight suicidal ideation, kind of an unhealthy relationship brewing out of pain]

Part 1 — Masterlist

fic title from Lovesong by The Cure but the chapter title is from Cut by The Cure

thank you @drop-of-void for proof-reading!! and i'm tagging some lovely folks now. @sleeby-anon @loversj0y @struggling-with-delia @l0veb0mb1ng @boiled-onionrings

xxxx

After the first month, it’d been easy to slip into the same old routine. Wake up too early, stare at the wall until your alarm goes off, manage either the longest shower ever or brush your teeth, then go to work and come home exhausted. Maybe eat. Stare at the wall a little more, go to bed. Music was optional.

And Seff wasn’t having it after the second.

“If men do this to you, then they don’t deserve you.” You grunted, listening to him ramble as you sat on the couch, arms feeling like noodles as you fold towels that sat on your bed a little too long, with Seff mopping your floor, the rugs rolled up and against the wall. The room smelt like fabuloso. “I’m serious. They don’t get to have a great night, express that they want to get to know you more, exchange numbers and then do jackshit with it.” He stops mopping, opting to lean against the length of it, eyes staring straight at you. You don’t make contact.

“Well it’s not up to me what they do, remember?” It’s hard not to be mean about this, you’re all too aware that when men do this, it’s not your fault. (...Entirely.)

“Vividly.” He says, before finishing up the last corner and putting the mop back in the bucket and putting it off by the laundry room. When he joins you, you’re halfway done. He helps you with the rest of the towels, getting you off the couch and forcing you to tuck the towels into the cabinets. When you get back almost ten minutes later, you find the living room fan turned on high and the floor drying faster, Seff himself back on the couch with gummy candy. He offers some to you when you join him on the couch. You dig a hand into the bag and pop them into your mouth, chewing on them as you let the cleanliness of the place wash over you.

“Doing anything feels like I’m moving through- through a thick goo, like tar. And I can’t get out of it.” The words come out only a smidge louder than a whisper but it was so loud between the two of you. Seff doesn’t say anything. So you continue. “It wasn’t… just him. It was all of those guys. Like, how could all of them have one night and change their mind so fast, like it wasn’t real for any of them.” But it was him. He was the last straw. He made the choice to come up to you and spend the last of the festival with you, it was him that wanted your number. It was all him and then- and then- tears prick your eyes again.

And it was him again, ghosting you, just like the others. They were so different from each other, how could they all do the same thing? There had to be a reason and the only logical one is that it was you. They regretted what they did, what they said, and they regret you.

You feel the hazy feeling wash over you, the tar-like substance coating your limbs and mind as Seff hums, wrapping an arm around you. He knew you so well, you wondered why he stayed. “They’re jackasses, don’t forget that, no matter how nice they were or how they smiled at you, they decided that being a coward was easier, it had nothing to do with you.” You nod, not really listening… but still, it’s a little nice to hear the words. Even if they didn’t stick like they should’ve.

He rubs your shoulder, offering you more candy and letting it sit in his lap when you decline. “Here, let’s finish up cleaning and then you hop in the shower. Vick wants you over for dinner tonight, she’s making your favorite, okay?” You nod, Vick was always so nice and sweet to you, snarky towards her husband. And on good days it didn’t hurt to be around them, to see them in love like crazy people.

“How’d you do it?” You don’t recognize the words coming out of your mouth, foreign and sickly tasting. He hums, sighing as he breathes out while he looks around the apartment.

“How’d I do what?” He asks.

“How’d you know it was her, I mean, you guys moved so fast, how did you- just- how?” Words failed you and you wanted answers but even on autopilot, you’re unsure of what you want to know. Of what you want to hear.

Silence grows as he mulls over the answer. Then he starts standing, getting you up on your feet with him, speaking as he pushes you to the shower, “I’ll tell you when you’re done, how about that?” He smiles as you reach the middle of the tiled bathroom floor, turning to him helplessly as you shiver.

He’s about to close the door when you stop him, reaching out with a hand. He stands there, unmoving, eyes moving up to meet yours and you gulp.

“Thanks.”

He smiles and he shuts the door with a click.

You undress, making no attempts to look at the mirror as you step into the shower, closing the curtains. The water hits your scalp and you try to picture your ails being washed away with the oils in your hair. You try to follow your old routine as best as you can but when thirty minutes pass and all you have to show for it is clean hair and nothing else, you turn the shower off. You’ll take a win where you can. You don’t entirely know it’s been thirty minutes to be fair, but when the water turns from hot to cold you can take the hint it’s time to get out.

Getting dressed and drying your hair with a shirt, you exit your room to find Seff on the couch, finishing the bag of gummy candy off. The corner of your lips twitch up as you toss the shirt at his head, snorting when he shouts and somehow falls onto the ground. “And after all that I’ve done for you!” He says as he wrenches the shirt off his head, throwing it right back at you. “I’ve rolled the rugs out AND I’ve got your bag and keys, and this is the thanks I get?!” A small smile plays on your face, wrapping your arm around his neck in a limp headlock as he continues to mumble about how unfair it was.

“Come on, you big baby, let’s get you back home to Vick,” and at the mention of his wife, he perks right up, handing your things over as he rushes to the door. You follow after him but as you lock the bottom lock, you hear a banging on your window. Your head snaps to the living room, just barely catching the dimmed blue sky of the night, nothing to be seen in the glass. You’d check it out but then you hear Seff call for your name. Turning away, you finish locking your door, following your best friend down the stairs and breathing in and out as your thoughts try to race ahead of you. Despite the genuine fear of a burglar… you couldn’t be bothered to worry too hard about it. One, there wasn’t a thing you could do now, pulling the seat belt over you as Seff started the engine. Two, and you’re sure it’s a bad thought but your mental health has never been known to be particularly okay, but you almost hope there’s somebody waiting for you. Whether they’d kill you immediately or to kidnap you, you’re clueless to which you want more, both are fine options. Maybe torture. Maybe you’d come out of this haze your mind seems to be stuck in.

You hardly notice the car parking, only when the door unlocks and you, automatically, take your seat belt off, opening the door and watching with blinking eyes as Vick, the beautiful woman she is, finds the two of you and hugs both at the same time. It’s a nice hug. Her soap smells nice. Makes you feel sleepy again.

Dinner is filled with laughs and despite your small fears, she doesn’t bring up Wilbur and she doesn’t bring up anybody and she doesn’t say that you deserve better. She just finds ways to make you laugh, make you gasp with the drama she’s heard, helps you with setting the table as Seff finishes off the toasted bread.

Wine is poured in your glass and Vick’s, juice for Seff. You quirk an eyebrow at him and he raises both in return, “what?” he asks as he lifts the fancy glass to his nose, swirling the liquid and then smelling it, with a satisfied nod.

“Pregnant?” He hangs his head in shame as Vick snorts, getting the salt and pepper from the kitchen.

“We wanted to be sure it was hers,” he sends a wink your way before beaming at Vick, accepting the bowl being passed for bread.

The night passes fast and before you can soak the warmth and happiness in for the long run, Seff is already dropping you off, double-checking that you’ll be okay for the weekend. “We’ll be at her mom’s place and you know her mom, middle of nowhere. No signal and—” you cut him off with a tight hug. He doesn’t say anything else until you let go. Until you’re sure the wine isn’t the only thing warm in your chest and belly. You’re slow to pull away but when you do, you walk backwards into your apartment, hand tight around the doorknob. The fear from before is back and though you know he has to leave, you wished he would stay. But that would mean asking. And you can’t ask that of him, not when he’s done so much for you already.

“See you when you get back.” He nods, tight-lipped.

“See you.” He starts the walk back to his car when you call out to him.

The words choke up in your throat but you manage to force them out, tasting bitter like vomit, “love you, be safe.” He parrots it back and tears blur your vision as you wave, watching as he disappears down the steps and then out of sight when his car drives away.

You swallow the lump in your throat, hoping you wouldn’t throw up on the floor after he mopped it, the fear of a familiar pit in your stomach as the door closes behind you. It’s quiet.

Way too quiet.

You turn your TV on, just loud enough to cover the ringing silence in your ears as you sit on the couch, not daring to check your bedroom or the kitchen for any intruders. You’re not sure what you want to find.

Head falling to your lap, phone open, your hand trembles as you press the icon for Wilbur’s contact. Despite him not answering before, you kept texting him and everyday it would stay on delivered, nothing would change. It felt maddening. Lonely. Desperate. You start typing a message out, speaking as your fingers moved, “Seff came over… helped clean and everything. I don’t know… where I’d be without… him.” Tears dripped onto your cheeks as you felt stupid and pathetic and- and- you couldn’t breathe, not around the sobs that escaped your mouth, covering it with one hand as you sent the message. He was just a guy and he only spent one night with you. It wasn’t even that special- you weren’t that special- why would he ever think-

It’s hard to focus but when the tears stop falling and you can breathe, at least through your mouth, you wipe the snot off with your sleeve.

Burglar be damned, you walk into the kitchen, tearing a paper towel off the roll and blowing your nose. It’s loud and it’s warm when you pull it away, groaning at the sight. “Fucking hell,” you mumble, tossing it into the trash.

The floor is cold beneath your feet walking back to the couch and when you sniff, you catch a whiff of that fabuloso again, pressing a hand to your forehead as you reach down to grab your phone. Your breath catches in your throat.

They’re- the messages- they’re not delivered anymore. He’s opened them. Thousands of emotions run through you in the matter of seconds. Air lodges itself in your throat, leaving you dizzy and unable to breathe as you think about it. Shame, humiliation. He’s seeing this pathetic, sad and lonely person vomit in his messages. Shock. Did he- did he lose his phone? Briefly angry, why couldn’t he just open it that night why did he have to wait till now? Staring down the phone screen, you can hardly recognize your thumb pressing on the call button. Without question, the cold press against your ear brings you to the moment, your mind clears of the haze as you’re forced to think, in milliseconds of a game plan. You thought of one over the last two months, wondered what you’d say to him, given the chance, but with your self-deprecating ass it was hard to think at all right now. Taking him back so quickly definitely was wrong, as was assuming he wanted you at all. Oh what to say?

As the call goes through and rings, hearing a vibrating noise outside the window you stiffen up. The one where you heard a noise from-

And the phone picks up, the vibration stops and all you can hear is the distant city noises, and perhaps the quietest panting you’ve heard. You approach the window, holding both hands at your phone, clutching as you whisper, “Wilbur?” Turning around until your back meets the wall beside it, you try to see if looking out would do anything. It doesn’t. It’s just as dark as it is inside of your living room, the only thing disturbing that inky blanket of darkness is your TV. You’re almost scared to turn it off. “Wilbur, what- are you there?” You didn’t know if you meant in general or right outside your fucking window but you can only imagine the answer when you see a phone drop onto the fire escape, a body falling to its knees, you can barely make out the silhouette. You drop your own phone when a hand smacks against the glass, dragging down as it smacks again and again. The shake in your hands makes it hard for you to flip the locks and you slide it up, just barely asking the question: just what in the hell are you doing??

But the hand falls off and a head of fluffy brown hair sticks in and he falls in with as much grace as a limp noodle, groaning all the way. You move him enough only to reach out and grab his phone, looking around to make sure nobody caught him sneaking in. You hope that in the case they do, they assume you’re only sneaking in a boyfriend— even if the assumption hurts to ache for.

“Fuck, Wilbur, what happened to you?” You hiss as you close the window, crouching as you help him sit against the wall, trying to look over him as his head rolls back. His eyes stare up at the ceiling as you look back at the window, catching sight of the red tint dragging down in the shape of his hand. Picking his wrist up, you do see the drying blood coating his skin. Your chest coils tight, thinking the worst of the worst. You try asking him what happened, where’s he hurt before his eyes drift down and find you, his face softening and a deep sigh rattles out of him, interrupted by a hiss and an attempt to press against his ribs. You need to call the ambulance, hell, take him to the hospital yourself but the way he’s sitting on your floor, already adjusting himself seems a little too… relaxed. As one can be relaxed when, no doubt, pain is at the forefront of your mind. “Wilbur, say something,” you beg with gritted teeth. You need a reason to not kick him out, to not pull him into your arms and kiss the wounds away no matter how tempting and how useless it would be. “Say something before I kill you myself.” And then he passes out.

You groan out in frustration, having caught his head in a panic when his body slumped over again and making a dive for the tile. “I cannot be doing this, Seff will kill me-” and then the sudden reminder, of oh yes, as of right now, you cannot call him. Despite more than likely being in the city together, you didn’t want him worrying over you again. You cannot keep doing that to him, he has a life of his own, Vick needs her husband and they’re going to visit her mom— and in your panic, a minute has passed and his head is still in your hand. You, out of nerves, started carding your free fingers through his hair, finding it… wet. You sniff close to his head and nearly groan again, yeah, his hair is wet with sweat.

You push his head back and reach around him, mumbling to yourself about how you should do it. Picking him up by the waist doesn’t do you any favors, neither does pulling on his arms. Bad idea in the first place. Sighing, you make a note to apologize later if he doesn’t die on you when you drag him to your room. It’s no question that he lies on your bed- after a towel has been laid out for him. If he’s bleeding, you don't want too big of a stain. You had considered leaving him on the floor… but then you couldn’t do it.

You check his arms, pushing his sleeves up and finding none of that. You check his head, nothing bleeding there. You take his shoes off but… that’s about all you do besides getting the first aid kit and setting it next to you, along with water and painkillers. If he was bleeding in the legs or chest or hell, even his feet, you needed him awake for that. And despite him literally being on your fire escape, which raises all sorts of questions mind you, you couldn’t undress him. You couldn’t.

After a few minutes, you shake his shoulder, giving his face a few smacks when he wakes up with a jolt, looking around until he finds you and then he groans, clutching at his side again, eyes shut tight. Then he tries to sit up. “Hey slow down there,” you say, holding onto his shoulder when it seemed he would stand up.

“Please, I should-” he swallows and you despise yourself for looking at his throat move, “I should go.”

“You shouldn’t be moving at all, now where’s the blood?” You speak fast, hoping to hide the shake in your voice if you were mean about it. He tried to fight you on it but when you pushed on his chest, stepping between his legs, he couldn’t move, head flung back as he tried to reel the grunts of pain in, trying to be quiet. “If you needed the hospital- or- or a clinic, you should’ve gone there first. But you didn’t, so you’re gonna tell me what’s hurting so I can help you.” He lays limp on your bed, unable to look at you as his mouth dropped open and snapped shut several times. “If you don’t tell me where it hurts, I’m going to stab you and then stitch you up myself and then throw you out my window so fucking- say something.”

It’s silent. Until it wasn’t. “Everywhere,” he rasped, his tongue darting out to wet his lips. “It hurts everywhere. I can’t-” he gasps, hand coming up to where your own still processes, in the middle of his chest and over yours“-think.” You retract your hand immediately, backing up as you give him space. Space for yourself.

“Is there anything bleeding?” You ask and when he shakes his head, you think back to the clear blood on his hands, on your window. It doesn’t add up but taking it with a generous fistful of salt, you want to scream. “Okay- okay. Fuck.”

In the end, you have him sit up, half-apologizing for the pain and the other of you lets him have it, he can handle it just this once. He could’ve called, he could’ve texted, anything, but no, he had to wait until he was literally too hurt to move.

“Did you break anything?” You ask, digging through the first-aid kit while you waited for him to take his shirt off, “because with the way you’re bitching about these bruises—”

“—bitching?” He cuts you off, shirt halfway over his head.

“— yes, bitching, you’re not bleeding, if anything was broken you would’ve, surely, gone to a clinic. A healer, just, fucking anybody. No, you had to come to me.” You say, pulling out the self-adherent wrap and opening it up, unable to fault yourself in finding a battered, bare-chested Wilbur on your bed and losing your voice for it. The hair on his chest that leads down his stomach that leads further down into his pants… you breathe in as he himself is quiet. Starting at his ribs, you have him hold it down as you begin wrapping it around his torso, dedicated to ignoring the heat of his skin, how close you are to him. How you have to stand with one leg between his and lean into his space.

With each go-around, you make sure it’s not too tight, just enough to keep pressure and when you tape it down, you have him lay back down, gathering the first-aid kit to put on the nightstand. Heading into the kitchen for an ice-pack. In the middle of making one in a ziploc bag, you wonder what the fuck you’re doing. You’re patching up a guy who fell into your living room after having ghosted you for two months.

You want to be mad at yourself, you want to punish yourself so badly for letting him in so easily.

“Listen, I just wanted to say—” he says when you walk in and you couldn’t help yourself, you chucked it at the bed and snatched the throw blanket on your dresser, ignoring any other attempts at conversation.

“Get some rest, don’t call for me unless that bag is melted.” You say over your shoulder, closing your bedroom door shut and you can’t help the pathetic slide down against it. Tears try to fall but you wipe them furiously. He does not get to wander in and fuck everything up. For goodness’ sake, you’ve just mopped.

Setting up camp on your couch, you lie down with the knowledge that yeah your neck will be shit in the morning, but you don’t care. You don’t care. It won’t matter in the morning because in the morning, he’ll be okay enough to get up and stand somewhat straight and maybe without help and he’ll insist on leaving. That’s just how it’ll go. He’ll say he never meant to end up on your fire escape and in the morning, he’ll apologize for taking up your bed. Because that’s just how it’ll go. And then he’ll go. And you’ll never see him again.

That’s how it’s going to be. It’ll never be anything more. You sniffle, can’t even stop crying for a night. How fucking useless. You bury your head into the throw pillow and shiver under the thin blanket. It’ll be over soon. It’ll be over and he’ll be gone and you can pretend that you never intended on letting someone murder you. You can pretend that you’re normal and pretend everything is okay. Breathing out, you let sleep fall over you.

You rub the ache in your neck, grimacing as you flip another pancake, successfully burning it. It goes onto a stack of burnt pancakes. Turning off the stove, you don’t even pull butter or the syrup out of the fridge. Maybe your bitterness will fade away with time… maybe you’ll be able to look back in time and say, it’s okay. It just wasn’t meant to be. For right now, you get to be petty and serve your bruised guest burnt food.

Opening your bedroom door, you halt in your footsteps; finding him fast asleep. The ice-pack is nowhere to be found. A sigh falls out of your mouth, the sound of the plate that knocks against the dresser is almost as loud as your defeat. You take the blanket you’d slept with and drape it over him, tucking the edges under him. The idiot slept on top of the cover. Standing up straight, you look at him. This is the first time you’ve seen him in two months, and you feel hopeless. He looks so peaceful, so handsome, so pretty, so helpless you can’t help but want to stay. But he’s hurt you. No matter what he has to say.

You breathe in deep before turning to leave and you would’ve made it out the door had he not reached out for you, grasping your wrist with cold fingers. You shiver under his touch as his head falls to the side, his hair falling into his closed eyes. “What you do to me is cruel,” you whisper, sliding down to the floor and letting him hold your wrist. You don’t know how much I regret meeting you and you don’t know how much I cherish meeting you at all.

It takes twenty minutes for him to wake up, two minutes after that for him to let go. You stand up, throwing a new shirt at him. This one happened to be completely oversized and old for you, perfect for him. “Get dressed and eat, I’m either taking you to a hospital or a healer you know, fifteen minutes.” You don’t give yourself time to loiter in the room, you don’t give him time to explain himself. (You know that maybe, just maybe, he didn’t mean to ghost you but let’s be real, you’re you. And he’s Wilbur. The math isn’t adding up. He just wasn’t that interested.)

About ten minutes after you walk out of your room, he stumbles out, gripping onto the walls and he groans with his mouth closed. You don’t let him see your flustered face at the sound, just walking out and letting him follow you to the stairs. You pull one of his arms over your shoulders and make a point not to talk to him, even when he tries to get you to let go. Saying all about how he can walk on his own and stairs are no problem… you couldn’t resist it though, he was pretty insistent that he’d be okay and maybe you’re still upset. You let go and watch as he falls down one step, catching him before he scraped himself up even more.

“And you said you had it under control.” You mutter and you can see he wants to say more but you send him a look that has him clenching his jaw again.

“Look, you don’t need to take me to a hospital.” He begins after the two of you are settled in your car.

“So you know a healer?” You turn to him, giving him a blank stare.

“Well- maybe- I-” he stumbles over his words as you start the engine.

“You have very limited options right now. Either I take you to someone who will help you or I will dump your ass on the front step of the nearest doctor. Pick one.” His jaw sets and you make it a point to stare ahead as he gives you directions.

In no time, you find yourself in front of an apartment building, helping him get out of the car and into the lobby. You barely helped him into the elevator before turning to leave, watching as he leaned against the elevator doors. He stumbled over his words again.

“I couldn’t text you. I wanted to, so badly.” He says, with the wettest eyes known to man.

“So you’re telling me, you saw I was texting, couldn’t respond  for some mysterious reason and you expect me to tell you it’s okay?”

“I’m not saying it was.”

“Two months, Wilbur, you left me alone for two months.” You say, throwing it out there and he wants to say more, you can see it so clearly. You can see he wants to say why, wants to tell you everything. His big, sad eyes stare you down, tears close to falling. You look behind you, holding onto the elevator doors as you lean closer into the enclosed space. “And we’re only talking because you showed up at my window, bruised to hell and back with someone’s blood on your hands. Talk to me when you’re healed. Because yeah, I have questions. And if you can’t answer them when you’ve healed up, just go back to ignoring me. It worked perfectly fine for the both of us, didn’t it?” You don’t know why you said any of that, bitterness and hurt chokes you up, your words coming out stilted or too fast. Because no way in any version of reality were you okay. You wanted the truth. You wanted to know exactly what went wrong that night for him to ignore you.

And if he’s being honest with you right now, you’re not sure what to make of it.

But you’ve said your piece and the first tear falls down his cheek. So you lean in, palm smacking the button for the doors to close. You don’t wait a second before turning around and heading back to your car. Breaking down right in front of it.

You were so far from being okay, so, so fucking far.

[tennesseemensclinic]

Trail Running in Tennessee for a Full-Body Workout Endurance Meets Nature with Tennessee Men’s Clinic

Experience the Ultimate Workout with Tennessee Men’s Clinic Trail Running in Tennessee

Tennessee’s trails offer a unique and invigorating way to stay fit. They combine the beauty of nature with the physical challenges of running on varied terrain. Trail running in this state is more than just a workout; it’s an experience that tests and improves physical and mental resilience. Tennessee Men’s Clinic emphasizes the importance of integrating such holistic exercises into daily routines, as they offer comprehensive benefits for the entire body.

The diverse landscapes of Tennessee—from the rolling hills of the Smoky Mountains to the rocky paths of the Cumberland Plateau—create the perfect environment for a full-body workout. Unlike running on a flat, paved surface, trail running requires constant adjustments in speed, stride, and balance. This not only engages the major muscle groups but also works the smaller, stabilizing muscles that often go underused in more traditional forms of exercise. These constant adjustments lead to a significant increase in lower body strength, particularly in the calves, quadriceps, hamstrings, and glutes.

Another key advantage of trail running in Tennessee is the cardiovascular challenge it presents. The state’s natural terrain includes a variety of elevations, which means that runners are often alternating between ascents and descents. Uphill running is a powerful way to boost heart rate and increase cardiovascular endurance, while downhill running requires control and precision, further engaging the muscles and improving coordination.

Beyond the physical benefits, trail running in Tennessee also offers mental and emotional advantages. The experience of running through forests, along rivers, and over mountains provides a mental escape from the stresses of daily life. The natural environment has a calming effect, helping to reduce anxiety and improve overall mental well-being. Additionally, the unpredictability of trail running—whether it’s navigating around roots, rocks, or streams—demands full concentration, effectively serving as a form of moving meditation.

Tennessee’s trails offer varying levels of difficulty for those who enjoy a challenge, making them suitable for both beginners and seasoned runners. Beginners can start with gentler trails that offer stunning views without steep climbs, while more experienced runners can take on rugged, high-elevation trails that test endurance and strength. This versatility makes Tennessee an ideal destination for anyone looking to elevate their fitness routine.

Trail running in Tennessee offers a comprehensive workout that benefits both body and mind. Combining cardiovascular endurance with lower body strength training provides a balanced approach to fitness that is hard to match with other forms of exercise. The mental and emotional benefits of being immersed in nature only add to the appeal, making trail running a holistic activity that can enhance overall well-being. Tennessee Men's Clinic recognizes the value of such activities in promoting a healthy lifestyle and encourages incorporating them into regular fitness routines for long-term benefits.

[swapnamakro]

Clinical consulting srvices

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[academicstrive]

The Role of Biomarkers in Clinical Trials

ClinicalTrials #Biomarkers #MedicalResearch #PersonalizedMedicine #AcademicStrive

In the medical research environment, biomarkers have taken the leading position in the realm of clinical testing. These physiological variables are necessary in the construction of new drugs and therapeutic measures, the disease pathogen root discoveries obtained and treatment effectiveness. The folks are constantly looking for up-to-date information so that readers can freely browse through the most recent research results on the Academic Strive portal.

What Are Biomarkers?

Biomarkers are elements that indicate medically a certain state of the organism, which are measured and quantified. They can be molecules, genes, or treatment change that happens in normal or pathological cell physiological activities. Through keeping track of the parts of the body like the heart, lungs, muscles, mouth or developing such components like proteins and genes, they are capable of providing accurate and timely information about the disease and predicting potential side effects of the drugs.

The Importance of Biomarkers in Clinical Trials

Enhanced Patient Selection: Biomarkers also play a critical role in identifying those patients most likely to respond to a particular intervention. As a result, the targeted approach significantly increases the efficiency and effectiveness of clinical trials. Monitoring Disease Progression: The role of biomarkers in research is to supply real-time information on the status of the disease, which helps healthcare practitioners make early corrections to the drug or other treatment methods at any stage of single therapy. This charting of the progress will be ensuring that all patients are given the best possible treatment throughout the trial.

Predicting Treatment Response: By using biomarker data to analyze, researchers have the ability to foretell how much a patient will be able to benefit from the treatment given. This outlook being a result of the predictive capability is why the patients are afterward mainly helped in designing individual treatment plans leading to best results as well. Identifying Side Effects Early: Biomarkers can detect potential side effects even before they are clinically manifested. Early recognition of apt effects allows for immediate action which in turn protects the patient and keeps the trial credible.

Challenges and Future Directions

Although the contribution of biomarkers to clinical trials promises immense gratification, there exists not so simple stumbling blocks to surmount. Biomarker assays' standardization, the requirement for large-scale validation research, and the integration of biomarker data into the regularity frameworks are including constantly everywhere among the existing problems.

Academic Strive represents the flagship for the publication of state-of-the-art research on biomarkers. We are the platform that provides free access to credible essays for the sake of broadening understanding and bonding researchers all over the world. Check out our biometabolites collection and become a partner in the development of medical research.

Conclusion

Biomarkers are the mechanism for running clinical research which is less costly, more efficient, and safer. As the medical society steps in to unseal their potentials, the concept of personalized medicine stands very positive in the future. We, at Academic Strive, are also the part of the mission by means of the platform we have created for the researchers to exchange their new pioneering ideas. Visit Academic Strive to get updates on the latest milestones in the biomarker research and beyond.

Through supporting the development of biomarkers, by this we will change the entire clinical time trials and we will bring a new optimism to many patients in every country all over the world. Be a member of Academic Strive that is leading this thrilling project and be the part of the transformation of the medical field.

[mushroomsolutionsinc]

Elevating Clinical Research: Mushroom Solutions' CTOps Delivers Comprehensive Solutions

Mushroom Solutions, a trailblazer in cutting-edge healthcare and life sciences solutions, proudly introduces the launch of its Clinical Trials Operations Automation Solutions (CTOps). This innovative platform is set to redefine the landscape of clinical research by addressing critical challenges in participant management and document processing.

Clinical Trials Reinvented: Mushroom Solutions' CTOps is a comprehensive and advanced suite of solutions crafted to streamline and enhance every aspect of clinical trials. From smooth participant onboarding and eligibility verification to extensive clinical trials support, personalized medication management, and multilingual services, CTOps ensures an unmatched level of efficiency and precision in trial operations.

Key Highlights:

Participant Onboarding and Eligibility Verification: Seamlessly integrate participants into clinical trials with our robust onboarding system. Conduct thorough eligibility checks to guarantee enrollment of only qualified individuals, enhancing trial integrity and efficiency.

Sentiment Analysis and Dropout Prevention: Evaluate participant feedback and sentiment using our advanced sentiment analysis tools. Implement proactive strategies to prevent participant dropout and boost engagement throughout the trial duration.

Comprehensive Clinical Trials Support: From site selection and patient recruitment to data management and regulatory compliance, Mushroom Solutions provides comprehensive support and guidance. Ensure the smooth and successful execution of clinical trials with our expert assistance.

Personalized Medication Management: Benefit from our personalized medication management support, including dosage tracking and adherence monitoring. Promote participant safety and optimize treatment outcomes with our tailored assistance.

Multilingual Support and Translation Services: Overcome language barriers with our multilingual support and translation services. Ensure clear communication and understanding among diverse participant populations, fostering inclusivity and accessibility.

Enhanced Online Visibility: Heighten the online visibility of clinical trial services with our strategic search engine optimization (SEO) techniques. Increase exposure and attract potential participants to relevant trial opportunities with our customized approach.

Optimized Web Content: Maximize the effectiveness of your web content, including websites and digital platforms, with our web content optimization services. Deliver a user-friendly experience that encourages participation and promotes the advancement of medical research.

Benefits of Clinical Trials Operations Automation Solutions (CTOps):

Streamlined Enrolment Process: CTOps ensures a seamless and efficient participant onboarding process, reducing administrative burden and accelerating trial initiation. Streamlined processes contribute to quicker enrollment, allowing researchers to focus more on the core aspects of the trial.

Enhanced Trial Integrity: Thorough eligibility checks are conducted to ensure only qualified participants are enrolled, maintaining the integrity of the trial and enhancing the reliability of collected data. Rigorous verification processes contribute to data accuracy, minimizing the risk of errors in trial outcomes.

Improved Participant Engagement: Utilizing advanced sentiment analysis tools, CTOps gauges participant feedback and sentiment, allowing for proactive strategies to prevent dropout and enhance overall engagement. Improved participant engagement leads to higher retention rates, ensuring a more comprehensive and representative study population.

Comprehensive Support: Mushroom Solutions provides end-to-end support, from site selection to regulatory compliance, ensuring a smooth and successful execution of clinical trials. Comprehensive support minimizes potential bottlenecks in the trial process and enhances overall operational efficiency.

Personalized Medication Management: CTOps includes personalized medication management support, offering dosage tracking and adherence monitoring for participants. This feature enhances participant safety, ensures adherence to treatment protocols, and contributes to optimized treatment outcomes.

[crimsonpublishers-oabb]

Artificial Cell Membranes as Bioinformation Hubs: Unraveling Therapeutic Networks through Nano-Informatics

The living cells are composed of bio-membranes which construct lipid bilayers composed mainly of phospholipids with proteins and cholesterol embedded in them. The internal organelles of the cell are composed of intracellular membranes and their unique structure modulates the permeation of molecules, like water, ions, and oxygen. Bio-membranes are considered as complex systems, and their state of matter is the liquid crystalline state corresponds to the fluid mosaic model of Singer & Nicolson [1]. Such state of matter undergoes a huge number of metastable phases that are named as ‘lipid rafts’ that are considered to act as information hubs.

These ‘lipid rafts’ are thermodynamic driven bioinformation hubs essential for the cell functions and for the survival of the organism [2]. The convergence of various scientific disciplines, including bioinformatics, cheminformatics, medical informatics, and nanoinformatics, has given rise to novel approaches in understanding and harnessing the potential of artificial cell membranes as bioinformation hubs. This paper delves into the intricate interplay between bio-membranes, lipid rafts, and thermodynamic-driven bioinformation, elucidating their pivotal role in establishing therapeutic networks.

Read More About This Article: https://crimsonpublishers.com/oabb/fulltext/OABB.000566.php

Read More About Crimson Publishers: https://crimsonpublishers.com/oabb/index.php

[dragon-hoard]

I hate my boss so fucking much he is 1 of 3 of the vets at my work and HE IS THE ONLY ONE WHO DOESNT BOTHER TO PUT THE USED NEEDLES IN THE GODDAMN SHARPS BIN. sometimes I open the garbage and theres just a fucking needle sitting right on top

all the lights get turned off at night so when u come in the morning u can always tell if one of the vets came in on emergency because they always leave the lights on. for my boss specifically I always know when its him because HE NEVER CLEANS UP AFTER HIMSELF AND LEAVES ALL THE DRAWERS AND CABINETS OPEN

[healthcareporium]

Exploring H1N1 (Swine Influenza): Market Trends and Leading Companies

In recent years, infectious diseases have taken the center stage, reshaping the healthcare landscape and emphasizing the need for constant vigilance. One such infectious disease is H1N1 (Swine Influenza). Understanding the market dynamics surrounding this disease is crucial for healthcare stakeholders. In this blog, we delve into the H1N1 market, its size, drivers, key players, and more. What is…

[cerservices]

Subsequent New Drugs clinical trials

Clinical Trails Of Subsequent New Drugs Application In India - Subsequent New Drug clinical study. Contact +91 7672005050 for Subsequent New Drugs Clinical Research In India

[slytherinslut0]

Mattheo Riddle. | We Are Done

Info: Mattheo calls things off during a nasty fight where you were only expressing your concern for his safety, putting an end to your months-long complicated fling. When he inevitably gets hurt and finds himself in the hospital wing as a result of his recklessness, you pay him a little visit, eager to get your revenge.

Word count: 5k

Tags: 18+, SMUT, Toxic Behaviours, Sadism, Masochism, Intense Bloodplay, Restraint, Dom!Reader, Sub!Mattheo, Begging, PIV, Sexual Punishment, Praise Kink, Degradation Kink, Humiliation.

A/N: went all the way to the depths of hell for this one☠️

The journey from the bustling opulence of the Great Hall to the clinical confines of the hospital wing unfolded like a protracted soul-search, nearly forty minutes of introspection that could have singlehandedly redefined the word regret.

A seething turmoil churned within, its intensity drawn solely from the arid kindling of memories involving your ex fling, Mattheo Riddle. Despite the passing week of newfound solitude, the inner maelstrom showed no fucking signs of abating.

The recollection of your fleeting intimate moments swarmed you, a ceaseless loop that played out in the theater of your mind--like an unresolved holodrama with seemingly no fucking end.

His imprint stained every fragment of your life; in the solitude of the shower, mental echoes followed the course of water, little rivers reminding you of the ones tracing intricate paths down his sculpted physique. Within the shared space of the common room, the mental tableau featured his fingers engaging in an intimate ballet, leaving the taste of his lips lingering in your mouth as they ever-so-dominantly stifled your lusty sounds.

And somehow, that wasn't even the worst of it. Oh, not even close. It was during the nocturnal realm that the memories unfolded their cruelest chapters.

In the shroud of night, it transcended beyond the mere visual replay of his figure dominating yours, or the sensory exploration of his hands traversing the curves of your body. It wasn't just the recollection of his teeth sinking into your neck that lingered. No, the intricacies of your mind wove a far, far more nuanced tapestry.

Nighttime summoned forth the vivid recollection of the encompassing warmth emanating from his broad chest, the haven discovered within the embrace of his strong arms, and the fragrant allure of his messy hair, intertwining with the visceral memories of each intimate encounter. His burning gaze that had seared into your consciousness was more than a mere look; it was an indelible mark, haunting the very core of your thoughts with the echoes of shared passion.

These were the nocturnal specters that besieged you behind closed lids, engaging in an unwelcome dance as you wrestled with the elusive embrace of sleep. These very memories, like a relentless blacksmith, stoked the inferno within, leaving behind the most acrid, bitter residue on your tongue--a taste of anguish and betrayal.

The haunting question echoed through the corridors of your thoughts: why had he subjected you to this intimate claiming, an emotional prison woven with shared intensity, only to abruptly extinguish it with the cold finality of three, sad little words.

"We are done."

And thus, even after the amount of passing time, all it took was a single sideways glance exchanged between Pansy and Draco during their spirited debate over impending assignments to inspire the catalyst for your abrupt departure. With a forceful clatter, you slammed down your fork and pushed up from the table, commencing a determined march into the unknown.

Their speculative gazes undoubtedly trailed your abrupt exit, but you paid no heed. The entire school was privy to the fact that you and Mattheo were done, seemingly officially this time--terminated by a colossal spat prior to one of his ludicrous nighttime escapades in the forbidden forest. Mattheo's hospitalization, a testament to the recklessness that marked him and his band of fools, left him nursing scratches, cuts, bruises, and a sizable gash on his lower abdomen.

Pansy's calls faded into the periphery as you strode away, your indifference resonating louder than any response could convey. The world around you blurred into inconsequential background noise, drowned out by the burgeoning tangle of spite that commandeered your thoughts. Initially relegated to the forefront, this resentment had now metastasized, occupying every crevice of your headspace.

The recollection of his outburst haunted you, a violent reaction triggered by your attempt to dissuade him from venturing into the forbidden forest. Advising caution, you found yourself confronted with accusations of control and a stifling of his fucking freedom. Hurtful words cascaded from his lips during that argument, culminating before he recklessly endangered himself in the perilous forest. All the moments of vulnerability you shared with him, surrendering yourself without reservation, only to be met with his callousness when you were simply trying to safeguard him.

And as the embers of revenge blazed within, so did the deafening roar for closure. The need to settle the score and the yearning for resolution thrived in the wake of an emotional maelstrom.

‘We are done’ felt insufficient—it couldn't conclude there. You wouldn't fucking allow it.

Approaching the hospital wing doors, a surprising fortitude replaced any expectation of your confidence wilting under the imposing pressure. Strangely, a heightened anger welled within you, as though Mattheo Riddle were the sun, each step forward intensifying the scorching heat enveloping you. With a decisive gesture, you flung the door open, your breath held in suspense as your eyes canvassed the beds. Yet, he remained conspicuously absent, amplifying the frenetic flutter in your heart into an unrestrained whirlwind.

"Miss? May I help you with something?"

You pivoted sharply, eyes ablaze, as if embers sparked from your gaze. "Mr. Riddle. Mattheo. Where is he?"

The nurse swallowed, brows furrowed in confusion, but she cautiously gestured toward the hall, taking a step forward. "We moved him into a private room yesterday. His father requested it. Third door to the left."

Your eyes rolled involuntarily as you turned away,  a silent commentary on the absurdity before you. Suppressing the impulse to scoff required a fucking Herculean effort--of course, his father would demand a private room for him. The bloody entitlement was as predictable as Mattheo's suffocating arrogance.

As your determined march neared its end, you found yourself standing before the designated door, caught in a tumult of fear and fury. Fingers trembled, folding in waves in a futile attempt to expel the excess energy coursing through your veins. This ritual had proved futile throughout the previous week, and it yielded no different results now. A frustrated exhale escaped through your nose as you charged through the doorway, propelled by a relentless surge of emotion.

Mattheo Riddle's vulnerability exceeded all expectations as he lay in his opulent private chamber. Shirtless, his body displayed a cruel artwork of black and blue hues, stretching beyond the healing gash on his abdomen. A chaotic tapestry of scratches adorned his shoulders, arms, neck, and the once flawless canvas of his face, now disrupted by a thin, blistering line over the bridge of his nose. A swallow lodged in your throat as you beheld him, a striking portrait of agony that rendered him almost unrecognizable.

"Why the hell are you here?" He stared at you, expression vacant. "Can't you comprehend simple instructions?"

With a cool, unwavering gaze, you shot back, "And miss the chance to witness your glorious downfall? Not a fucking chance, Riddle."

Mattheo clenched his jaw, exhaling sharply as he adjusted against the sheets. "You're insufferable."

You sneered, advancing with measured steps. "Coming from you, that's a compliment."

Advancing, you scrutinized his form, taking in the mosaic of fresh scars that adorned his skin. Arriving at the bedside, your gaze drifted downward, noting that beneath his waist, he was clad only in boxers. A scant, white sheet was the sole guardian of whatever remained of his dignity.

Mattheo's snarl reverberated in the room. "If you're here to extend your fucking pity, please, spare me."

A sharp retort escaped your lips, your eyes dancing with a hint of amusement. "Oh, I'm not offering pity...though you do present quite the pitiable fucking sight, I'll give you that."

"Then what the fuck do you want?" Mattheo's voice carried an edge, his eyes narrowing with impatience. “I told you, we are done.”

A pregnant pause filled the room as you let his question linger, a mental reel replaying the relentless week of torment he had unleashed upon you. Your gaze lingered on his tousled chocolate curls and once-enticing plush lips, forcing yourself to traverse the memories of months marked by a tumultuous dance between pain and pleasure. The realization hit like a sledgehammer--all those moments, the highs and lows, seemed to have led to an abyss of pure fucking nothingness.

A furrow etched your brow as you looked down at him. "It's unbelievable that I let myself get ensnared into feeling something for you."

"Your feelings were your own choice," he quipped, his head falling back with an air of indifference, eyes drifting to the ceiling. "Don't blame me for your poor judgment."

Your frown etched deeper lines on your face, the surge of anger unmistakable. "Regardless, you still manipulated me like a fucking puppet."

"Amusing how complaints disappeared when you were screaming for more every damn night," he retorted, lids fluttering with evident irritation. "Your anger's just a cover for the fact that you'll have to find a new playmate now...have fun chasing those highs, princess, but I promise you'll only end up disappointed."

Your jaw dropped in disbelief, gaze narrowing into a potent mix of anger and hurt. "You're a real fucking prick, you know that?"

Mattheo regarded you with eyes that seemed to hold nothing but emptiness. His silent response coaxed your hands to curl into tight fists, and your chin to tremble with the pressure of boiling blood. You hadn't come here for him to treat you like a mere specter, to act as if you were invisible, as if you were nothing--something you knew you had never been. And still weren't.

"Answer me," you hissed, your voice shaking with a blend of frustration and desperation.

He remained silent, his gaze an unyielding anchor in the stormy sea of your emotions. The void in his pupils became increasingly maddening, an inscrutable abyss that left you grappling with the uncertainty of what the fuck he was even thinking right now.

"Answer me, Riddle." Your demand sliced through the air, a fervent plea for any sign of acknowledgment.

But he remained stubbornly mute.

Your chest surged with frustration, the world momentarily blurring in your escalating anger. "Say something, damn it!"

It was only when the sting of his skin met the back of your hand, and red streaks of blood marked your knuckles, that you realized you had slapped him, reopening the scab on his cheek. Yet, that wasn't the shocking part--though it certainly played a role--what truly stunned you was the quiet, wanton moan that escaped Mattheo's lips, his lids fluttering while his body tensed against the bed. In awe, you gulped.

And then, a peculiar, wicked force stirred within, a voracious entity feeding on the months of torment he had subjected you to. Something that hungered for more.

So, succumbing to its dark allure, you withdrew your hand and unleashed another sharp, resounding slap across his cheek. Blood painted his face, and Mattheo groaned, fingers clutching at the sheets as his hips thrust into the air, his arousal blatantly revealed beneath the fabric. Spellbound, you observed as he collapsed back onto the mattress, his eyes fluttering open, holding a gaze that teetered between vulnerability and desperation.

Between the conflicted expression in his eyes and the pulsating bulge between his legs, the sinister impulse within you deepened, intertwining with a more primal sensation. One unmistakably identified as pure, unbridled lust.

"You fucking like that, don't you?" You breathed, your lips twisting into a sadistic grin.

"Are you trying to hurt me, princess?" Mattheo's intense gaze focused on you, alternating between his increasing arousal and your exasperated expressions. "You'll have to put in more fucking effort than that..."

"Hm." You hummed, grin widening. "If you insist."

You locked on to Mattheo's gaze, feeling empowered by the way his normally stoic expression was now clouded with a burning need. With a coy smile, you swung your knee onto the hospital bed, letting your skirt ride up around your hips and exposing your panties. His brown eyes lingered between your legs, and you could feel the heat of his gaze against your skin as you climbed over him, straddling his strong thighs. He tensed as his eager cock twitched beneath you, silently begging for more.

The power dynamic between you had shifted so drastically in this moment. Mattheo Riddle, famed for his cunning and ruthlessness, was now completely at your fucking mercy. It was an intoxicating feeling, knowing that you had the power to make him feel truly vulnerable.

"So weak," you spat, a wicked grin spreading across your face as you dipped your hips just enough to skim the head of his cock. The sight of his full-body convulsion was mesmerizing, and the shaky breath that left his lips told you everything you needed to know.

You could tell he was still in pain, but there was something else there too--desperation.

"Poor boy," you murmured, running your fingers down the curves of your own figure, taking pleasure in the sensation of your own heat as you slipped your hand between your thighs, caressing yourself. "This is what you want, isn't it?"

Mattheo's eyes fluttered closed, his mouth falling open in a low groan. It was clear he was entranced by the sight of you touching yourself, and the way your words dripped with sinful seduction only added to his lust.

"Yes," he gritted out through clenched teeth, his hips bucking up to meet yours. "This is what I want."

"Look at you...so fucking needy..." you clucked your tongue and chuckled, extending out your free hand and running it along the wounded flesh of his chest, digging in with a little more force than you'd intended, judging by the groan that left his lips and the blood that split through the scab. "You're such a pathetic mess, Matty...it's almost too easy to control you like this..."

"Go to hell." His jaw tightened, a vein throbbing in his temple as he recognized the truth in your words. "You don't control fuck all."

"Oh, is that right?" you snarled, leaning forward and pushing your hands into his stomach, pressing down on his wound with added force, now. His face twisted in pain, and he let out a strained grunt. "How about now?"

Your heart was thundering with adrenaline, and while you had undoubtedly expected him to be furious at you for causing him harm, as he met your gaze, you saw something else entirely. There was a desperate need in his eyes, a yearning for more of the pain and pleasure that only you could provide. His lips were parted, his breaths coming in short gasps as he struggled to contain the sensations coursing through him. Despite the pain, there was a sense of longing that tugged at your heartstrings, filling you with a powerful desire for more of this intoxicating mixture.

"More," he whispered, his voice low and husky with need, barely above a breath. "Do it again."

"Oh, I don't fucking think so..." you sneered, your cunt clenching involuntarily at his request. But you were determined to make this man suffer. To humiliate him just as bad as he'd humiliated you, time and time again. "If you want something, you’ll have to ask for it nicely…I want to hear you beg for me."

Mattheo grunted again, bucking his hips, trying to grind back despite the pain of his injuries. Finding that impossible, his hands went to your waist, gliding up and down your thighs as he attempted to move you faster along his member, craning his head forward to get a better view. You scowled and smacked him away.

"I don't recall extending an invitation for your touch," you asserted, a glacial edge to your voice. "Why would I want your hands on me? After everything you've fucking done?"

His fingers balled into fists, exhaling when his head fell back against the pillow. You could feel him aching below you, already entirely fucking anxious to get inside of you. But then, he was still, hungry eyes trained on yours as he waited for your prompt.

"That's better," you purred, and found the next words coming out before you'd even thought them. "Good boy."

Your hips moved sinuously against his, a deliberate motion that left him breathless, his fists tensing against the desire to seize hold of your flesh. The surge of power was intoxicating, a heady blend with the fervor of your overwhelming desire and simmering rage. More than ever, your yearning for him to suffer consumed you. With a wicked grin, you lifted your hand to your lips, sensually running your tongue along the length of your crimson-stained fingers, sucking off the remnants of his blood. The sharp note of copper lit up your palate, sending a delightful shiver through your being.

"Mmm...you taste so good." You met his gaze between the long licks of your digits, his taste coating your mouth. "Wanna try?"

Mattheo remained silent, his gaze tracing the movement of your tongue as he moistened his lower lip. You enveloped one of your fingers with your lips, emitting a soft hum as you sensually cleaned it, gliding it in and out with deliberate slowness. Finally, you withdrew it with a wet pop, eyes rolling in dramatic effect.

Mattheo's jaw constricted, the sinews in his forearms taut from the tension in his fists. "Please..."

But you, unfazed, dipped your fingers back into the trail of blood leaking from his gash, adorning your skin with a bold red hue before returning them to your mouth.

"Mm, not good enough, I’m afraid..." you murmured, eyes twinkling with sadistic satisfaction. "You'll have to do much better than that, big boy..."

A growl echoed in Mattheo's throat while he gripped your thighs, pushing you down onto his swollen cock. His own hips thrust up against you, seeking any friction, any pressure at all from your heat. Frowning, you slapped his hand--and to your amazement, he pulled back, averting his gaze.

"These hands of yours are growing quite fucking insolent," you observed with a sly smile. "It's high time we addressed their rude misbehaviour."

A sinister grin etched across your lips as you shifted, smoothly extracting your wand from its thigh strap. With a deft flick, you summoned restraints, securing Mattheo's wrists to the metal headboard. His lips parted, eyes smouldering with desire, pulsating beneath you as the tightness closed around his wrists. Once finished, another few flicks ensured the door was locked, and the room was cloaked in a silencing charm.

"Much better," you said, tossing your wand aside. The gleam in your eye was almost maniacal as you reveled in the exquisite agony you were causing him, feeling a sense of power and control that you had never experienced before. "How's that feel, hm? Ready to utter those pleas for me, Riddle?"

"You're going to regret this, little witch..."  he spat out through gritted teeth, his gaze locked onto yours. "Nothing you could do to me is worse than the fate that awaits you when I get out of here…your days are fucking numbered."

Involuntarily, you clenched at his threat, a sly smirk playing on your lips as you dipped your fingers back into the pool of blood emanating from his wound--and with a decisive move, you seized his jaw with your free hand, thrusting your bloodied fingers past his teeth before he could voice a protest.

"Now isn't the time for your futile threats, Mattheo," you husked, tilting your head. Your fingers pushed forcefully into his throat, emphasizing your point. "Look how fucking pathetic you are...if only your friends could see you now...big tough guy, bound and gagged by his own bitch…it’s beautiful, really."

Abruptly, you withdrew your fingers, leaning back to assess your handiwork. His wrists were securely bound, a vivid red imprint gracing his skin, while his mouth shimmered with the subtle traces of his own blood. It was a tableau of perfection--humiliating yet exquisitely so. The image of him squirming against the taut restraints, his chest rising and falling with each desperate breath, compelled your hand between your legs. Sliding up your skirt, you explored through the delicate lace of your panties, skimming eagerly over your clit.

"Fuck," you murmured, glimpsing his mouth, “you look perfect like this."

This was retribution, and as you teased yourself while admiring the pathetic sight of him, thoughts buzzed with the torment he'd inflicted--the scalding intensity of his erratic behavior, the icy indifference he wielded, treating you with disdain, unfounded accusations of infidelity, and the frigid distance he maintained. The searing resentment flared as you recollected the havoc he'd wreaked upon your life.

It was months of emotional manipulation. A pattern that was impossible to acclimate to. His cycle of hot and cold, the relentless mistreatment, the baseless accusations, and the moments of aloofness, all preceding his inevitable return, pleading for your affection--this was the culmination of his deeds. More than anything, this was the reckoning he deserved.

"Come on, princess..." he muttered, eyes wide and pleading. "For Godrics sake, please...fucking please..."

A grin creeped across your lips, your heart leaping with excitement. You'd finally fucking broke him.

"There we go, Matty...that wasn't so hard, was it?" You purred, inching backwards along the length of his thighs, reaching out to pull the cover from his waist in an excruciatingly slow fashion, exposing his black briefs. "I love hearing you beg for me...you're being such a good boy..."

Mattheo's response came in the form of an exaggerated huff, and his eyes locked onto yours, silently pleading for your touch to alleviate the burning desire between his legs. Your grin expanded, reveling in the palpable tension.

"You want me to fuck you, Matty? Do you think you fucking deserve that?" You cooed as you caressed his erection through the fabric, glaring at him while he jerked and shook from your touch. It was incredible, watching him trying to thrust into your fist, whimpering, head lolling while you sped your ministrations. "Do you think you fucking deserve me?"

His groan reverberated, his body twitching beneath the firm clasp of your fingers. His lids fluttered, and his head arched back in a nearly imperceptible shake of denial.

"You never fucking deserved me, did you?" Your frustration at his silence echoed in the air as you delivered a sharp crack across his face, prompting a gasp from him. "Fucking answer me, Mattheo!"

"No!" he finally hissed, his knuckles whitening as his entire frame tensed. "Fuck! No! I didn’t…”

"That's right, you didn't…” you laughed, shaking your head. The sinful delight coursing through you at his torment was undeniable. "At least you can finally fucking admit it...a tiny step towards what might pass as progress, I suppose."

As Mattheo huffed, not daring to meet your eyes, you sighed, finally feeling as though some of your anger had dissipated. Not by much, but by enough. Granting him the smallest percentage of mercy, you wrapped your fingers around the waistband of his boxers, freeing his needy, throbbing cock--the length of his smooth heat springing back and slapping against his belly, a low groan leaving the depths of his throat as it did.

You clenched at the sight, the pool of heat in your abdomen expanding throughout your entire body now, your mouth practically watering at the mere vision of him. Just when you thought this whole thing couldn't get anymore perfect. Gods, he was undeniably fucking delicious.

"Tell me what you want, Mattheo..." you said, wrapping your fingers around his cock, slicking the bead of precum around the head, twisting your wrist as you stroked him. "Tell me what you need."

His eyelids pressed together in bliss as he panted, the rhythmic movement of his throat visible with each swallow. In the throes of pleasure, he surrendered himself to the intensity of your touch, the heat enveloping him in a cocoon of sensation.

"You..." was his only reply, head snapping back and forth, thighs tensing, cock twitching. "Please-fuck-"

"You like that?" you purred, biting your lip. "You like when I jerk your cock like this? Hm?"

Mattheo's jaw was slack with desire, his voice laced with breathy need, "yes..."

"Yeah?" You purred, tightening your grip, increasing your pace as you stroked him, leaning down slightly to spit on the tip, slicking your saliva along his shaft. "Who else could make you beg, huh? Who the fuck else can make you this fucking hard?"

"Fuck-" he choked, chest rising and falling in shallow bursts, you could tell he was close. "No one-princess-fucking no one..."

"Mhm...that's fucking right, Riddle..." smiling, you threw your head back, your other hand resuming its motion on your clit, teasing yourself as you continued stroking him. "You know you can't fucking live without this...I don't know why you have to make things so goddamn complicated..."

"Fuck," he hissed, sputtering your name, "please, fuck me, please. I fucking need you."

"Shit...you're just spoiling me now," you mewled, your pussy clenching undoubtedly at his words. "Such a good boy...so eager to please me, hm?"

Mattheo released a long, exasperated sigh as you released him, shifting yourself closer. With a swift motion, you shimmied your panties to the side before you aligned his cock with your dripping core--the moan that escaped your throat was deep and lengthy as you sank onto him, feeling every inch of his hard, aching cock stretching you wide, filling you up with ease. Mattheo's body lifted from the bed in response, a sound somewhere between a sob and a scream escaping his chest as you enveloped him to the hilt. Leaning forward, you placed your palms on his stomach, shifting your weight to the heels of your hands as you began to slide up and down his shaft.

"Fuck," you breathed, lids fluttering. "I missed this cock...shit, you feel so good..."

Mattheo's only response was a string of shameless, guttural moans, his eyes rolling to the back of his head as he surrendered to the potent mix of pleasure and pain. His body writhed beneath yours, his abdominals tightening in response to your movements. You panted heavily, bouncing up and down on his cock, taking pleasure in every inch of him slamming deep into your wet, eager pussy.

With each movement, you drove Mattheo wild with desire, listening to his moans grow louder and more intense with each passing moment.

Having control was entirely different--you were able to drag him into you, squeeze him tight with your walls while you slowed your pace, slam down onto him and make him howl. You watched him struggle below you, realizing he was trapped at his peak--and you were happy about it. This. This was close to what he deserved.

"I fucking hate you," you growled, the depth of your emotion evident in every word. "You embedded yourself into every part of my life and now you want to just fucking end things? Just go back to being fucking strangers? Over nothing?" Your voice cracked, the words flowing from your lips without restraint as you continued to ride him, hips moving in an untamed rhythm. "Why do you always fucking do this to me? Fuck-why?..."

Between his deep groans, his shuddering gasps as his wrists fighting their resistance, he managed to shake his head, his noises only growing louder the harder your rode him.

"I...I'm..." the words were forced through barred teeth, his eyes pleading for mercy. "I'm fucking sorry."

"Are you mine, Mattheo?" Your voice was strained with exertion, sweat growing on your forehead. "Were you ever fucking mine? Or was it all just a big game to you?"

"No,” he stammered, almost wincing. "No!"

Unable to resist the intense sensations coursing through you any longer, you brought your fingers back to your clit, setting a frenzied pace as you massaged the stiff nub with the pads of your fingers. You could feel Mattheo pulsing inside you, could feel his overly urgent need to cum, but right now, all that mattered was your own pleasure. As you worked yourself toward climax, your breaths grew ragged, soft moans escaping your lips as your body responded to your own touch. The pressure inside of you was building with each passing moment, urgent and insistent, and you knew that you wouldn't be able to hold off for much longer.

"Say it," you panted, eyes rolling and body trembling as you slammed down on him again and again. "Tell me who you fucking belong to."

"Fuck-fuck..." he grunted, teeth bared, eyes squeezed shut in concentration. "Please, princess...you keep squeezing me like that and I'm going to fucking cum-"

"If you want to cum, you'll fucking say it, Mattheo-" you practically moaned, entire body quivering with excitement. "Fuck-say it..."

A string of whimpers slipped past Mattheo's lips, his fists balled so tight it looked almost painful. "Fuck--you! I'm yours, fuck..."

Every word leaving you was a curse, and between every word was a strangled moan, resonating through your throat as you worked your clit fasting, fucking yourself on his cock harder.

"Gods, Matty, I'm going to cum," you moaned. "I'm going to cum on this thick fucking cock-fuck..."

Without being able to hold off any longer, you shattered, your hips jerking and twitching in an erratic rhythm, free hand digging into the flesh of his chest as you clenched and pulsed around him, forcing another onslaught of pleasured whimpers to leave his throat before he too reached his high--the tight heat of your orgasm sending him over the edge, twitching and thrashing beneath you as you continued riding him through your collective highs, not beginning to slow until the aftershocks began to rumble through you.

And after you stalled, you allowed yourself a moment to regain composure before you wearily eased yourself off him, releasing a prolonged breath--with a cautious movement, you reached over and gathered a sampling of your intertwined cum on the pads of your fingers, briskly bringing them up to his lips.

"Taste what I did to you," you murmured with a smirk, relishing in his groan against your flesh. Methodically, you glided your fingers against his bottom teeth, leisurely pulling them from his mouth. "Tastes good, doesn't it?"

His breaths lingered in the air, an unspoken acknowledgment of his silence, his eyes seemingly unable to leave your form. With deliberate movements, you leaned over, deftly undoing the restraints that bound him. As you meticulously adjusted your appearance back to its usual state, a mask of calm control, your gaze shifted towards the door, a calculated glance.

"May your recovery be swift, Riddle," you uttered with a tone that held a hint of farewell. "Until next time."

[swapnamakro]

What are the most important steps for a successful EU IVDR clinical evaluation?

When it comes to a successful EU IVDR clinical evaluation, there are several crucial steps to follow:

Define Clear Objectives: Start by outlining the specific goals of your clinical evaluation, aligning them with the requirements of the EU IVDR.

Comprehensive Data Collection: Gather all relevant clinical data, including pre-existing data and new studies, ensuring that they meet the necessary standards.

Thorough Data Analysis: Analyze the collected data rigorously to demonstrate the safety, performance, and benefits of the device.

Continuous Documentation: Maintain detailed and up-to-date documentation throughout the evaluation process.

Expert Review and Validation: Have your evaluation reviewed by qualified experts to validate your findings and ensure compliance.

By following these steps, you can achieve a robust and compliant clinical evaluation under the EU IVDR.

For more info:

https://www.makrocare.com/blog/eu-ivdr-performance-evaluation-in-8-steps/