#contract manufacturing for injections

[third-party-manufacturers]

Pharma Manufacturing Companies in India | WHO Certified Pharma Company

Collaborating with pharma manufacturing companies in India, such as Unimarck Pharma, opens up exciting opportunities. You'll gain access to cutting-edge facilities, a skilled workforce, and expert knowledge of regulations, ensuring top-notch production quality.

[pharma-company-in-chandigarh]

Pharma Third Party Manufacturing Services | Unimarck Pharma | +91-172-2244500

Pharma third party manufacturing services | Unimarck Pharma | Call us today +91-172-2244500 | We meet the highest standards in our production process keeping safety and effectiveness as our priority.

[unimarckpharm]

What Are The Key Components Of An Ointment Formulations

In ointment manufacturing, the formulation is essential for ensuring the product’s effectiveness and stability. The key components include active pharmaceutical ingredients (APIs), bases, and excipients.

Active Pharmaceutical Ingredients (APIs) are the main ingredients in any ointment, providing the therapeutic effect. Their selection depends on the intended treatment, such as anti-inflammatory or antibacterial purposes.

Bases form the foundation of the ointment and affect its texture, absorption, and release of APIs. Common bases include petrolatum, lanolin, and hydrophilic ointment. Each base is chosen based on the desired consistency and how well it interacts with the skin. For example, petrolatum creates a protective barrier, while hydrophilic bases are absorbed more easily.

Excipients are added to improve the ointment's stability, spreadability, and shelf life. These can include emulsifiers, stabilizers, and preservatives. Choosing the right excipients helps ensure that the ointment remains effective over time and does not cause skin irritation.

Unimarck Pharma excels in selecting and combining these components, ensuring their ointments are effective and safe, meeting strict quality standards, and providing reliable therapeutic solutions. Contact us today for third party manufacturing for ointment.

[rising-gpi]

Plastic Injection Mold & Molding Parts Manufacturers in India since 1968

Looking for plastic injection mold and molding parts manufacturing Companies in India, Delhi, NCR. Then contact with General Plastic Industries in India. Leading since 1968.

[cronusbiotech]

Cronus Biotech- Pharmaceutical Manufacturing Company

Cronus Biotech Ltd. is one of the fastest-growing pharmaceutical companies in India headquartered in Ahmedabad Gujarat. We have also started exporting to countries like Nepal, Philippines, Africa, Bangladesh, Bhutan, and Sri Lanka. With our own manufacturing plant and research & and development division. We manufacture in wide range of Pharmaceutical Tablets, Capsules, Body Care Products, Syrups, Dry Syrups, Cough Syrup, Drops, Injectables, etc. Our main motive is creating medical products keeping in mind customer requirements, efficiency, and reliability.

We specialize in Pharma PCD, Pharma Franchise, Third Party Manufacturing, Contract Manufacturing, Pharma Distributors, Ethical pharma, Medicine Distributors, Ethical Pharma co, Pharma propaganda companies, Contract Manufacturers, and PCD pharma companies. Our vision is Disease disease-free world, to offer affordable, safe, and effective healthcare solutions to society in the coming years.

Cronus Biotech boasts state-of-the-art manufacturing facilities equipped with cutting-edge technology and automated systems. We focus on good manufacturing Practices, maintaining sterile and controlled environments to prevent contamination and ensure the production of high-quality pharmaceuticals. We produce a diverse range of portfolios encompassing prescription drugs, over-the-counter medications, vaccines, and more. This expansive portfolio caters to various medical needs, addressing ailments ranging from common colds to life-threatening diseases.

We are committed to: • Making healthy and affordable products • Employ well-researched Modern Technology • Expertise in a Wide Range of Pharma-services • Strive for a free and healthy millennium • Availability of the medicines at affordable price • Best quality

As a pharmaceutical manufacturing company focuses on producing medicinal products, including prescription drugs, over-the-counter medications, vaccines, and other healthcare-related items. We invest significantly in R&D to discover and develop new drugs, improve existing formulations, and create novel delivery methods to enhance treatment efficacy and patient experience. We focus on quality control measures in place at every stage of manufacturing to ensure the products meet defined specifications and standards, minimizing risks and ensuring patient safety.

[sleekervae]

Wicked Games ❅ 2

Masterlist

Pairing: Coriolanus Snow x socialite!fem!reader

Summary: Sable has a proposition

Warnings: mentions of war, politicians being politicians

Word Count: 4,120

Saying the Hanovers were rich was an understatement. Phillip Hanover, a district resident caught in the crossfire of the First Rebellion, was a desperate bio-engineer determined to protect his family from war. Needing money, he turned to what he knew best: manufacturing medicine. He created topical creams, pain relief pills, antiseptics—anything people needed to heal their battle wounds. Despite his lack of experience, Phillip's experimentation paid off, and his medications became highly sought after for their quick healing properties. Eventually, he moved on to more powerful injections and sedatives, making a name for himself and drawing attention from the Capitol.

Volumnia Gaul believed in keeping enemies close. With Hanover's cutting-edge technology, she knew the Capitol needed him on their side. Backed by Crassus Snow, the Capitol made Hanover an irresistible offer: money, protection, and a legacy. Hanover had a lot to consider, knowing his reputation as a district hero would be destroyed. But in the end, money spoke louder than reputation.

Within six months, Phillip Hanover set up shop in the Capitol. His wife and two children no longer lived in squalor, he had money in his pocket, and he had the sponsorship and support of Panem's superiors. Requests for basic medicines evolved into demands for pushing technological boundaries to extend life expectancy and speed up recovery times. There were even requests for pharmaceutical weapons. Hanover, blinded by dollars and ambition, never paused to question what he was doing. If General Snow had a request, he would do his best to fulfill it.

His empire would continue to expand even after the war: manufacturing warehouses, marketing, and a great reputation for quick and effective results catapulted the Hanover name into Panem infamy. Hanover Pharmaceuticals would draft up different contracts between the districts, delivering the most and effective products to those districts who had the most to offer. And very quickly the Hanover name represented success, entrepreneurship, and respect. It also garnered a traitorous, slimy reputation in the eyes of the districts.

It was no matter to Phillip, though he made sure to remind his two daughters every chance he got of where they came from. From shoes with holes in the soles to satin dresses, from beds with squeaky springs and no heat in the winter to lavish vacations with the best accommodations possible. The eldest sister, Seline, was grounded and empathetic to their past, while her little sister, Sable, was determined to rid herself of any trace of District 3. She was the baby of the family, of course she was spoiled rotten. Though nevertheless, the sisters stayed close as they grew up.

The Hanover estate was quiet, save for the soft clink of china as Sable’s parents sat across from her in the drawing room. Her mother, Eleanor, looked frazzled, her fingers wringing the hem of her floral shawl. Her father, Phillip, sat with a stony expression, his frustration barely concealed.

“Sable, darling,” Eleanor began, her voice tinged with a blend of worry and exasperation, “you know how important it is for us to see you settled. You’re not getting any younger, and we’ve invested so much in your future. We can’t just let all of our fortune go to waste after we’re gone.”

Sable looked up from her book, her gaze indifferent. “I don’t see what the rush is. I’m perfectly content as I am.”

Phillip leaned forward, his voice edged with frustration. “Content? Look at your sister. She’s already engaged to a respectable man, and you—well, you’re still playing the socialite with no real direction. You can’t expect to squander our wealth and remain unbound forever.”

Sable raised an eyebrow, her expression aloof. “Seline’s choices have nothing to do with me. I have my own plans.”

Eleanor’s face crumpled with worry. “But you’re not a child anymore, Sable. We’ve arranged a fine match for you—someone who’s well-suited to continue our legacy. It’s not just about marrying for love; it’s about securing our place and our future.”

Sable’s gaze turned cold, her lips curling slightly. “And what if I’m not interested in your arrangements? I don’t see why I should settle for a life I don’t want just to please you.”

Phillip’s frustration boiled over. “This isn’t just about you, Sable. It’s about our family’s standing, our name. You can’t just live frivolously and expect everything to be handed to you. If you don’t take this opportunity, you risk throwing away everything we’ve worked for.”

Sable closed her book with deliberate slowness, standing up and smoothing her dress with practiced elegance. “I’m aware of my duties, but I refuse to be coerced into a life I have no interest in.”

Eleanor’s voice trembled as she tried one last time. “Sable, please, consider what we’re asking. We only want what’s best for you.”

Sable’s eyes were steely as she met her mother’s gaze. “You haven't known what's best for me since I was a child; when we came to this god-forsaken city in search of a better life.”

Phillip’s face was a mask of frustration as he glanced at his wife. “And that better life put that dress on you, as well as made sure you had food and --”

"And warm bed and a roof over our heads and never had to want for anything again," she started out of the room, her book clenched under her arm as she turned her back on her parents, "I'm well aware,"

The weight of their expectations felt distant to her, overshadowed by her own desires and independence. They were right about one thing: she couldn't keep up with the socialite game for the rest of her life. She needed stability, a plan to make sure she came out on the other side.

Sable grew up with the understanding that if you wanted something bad enough, you would work for it by any means necessary. Any means. And being the daughter of one of the richest families in the Capitol brought her a lot of attention. She embodied birth-of-Hollywood glamour, sophisticated and beautiful beyond debate. She thrived on the attention, after all. Because of her looks and her background, people didn't give her much credit for her brain.

To the blight of businessmen, rich kids, and even a few Hunger Games victors, Sable had a rare talent for listening and remembering. Whether it was over martinis or during intimate pillow talk, men found themselves spilling their thoughts, their secrets, to her. She made them feel comfortable and safe. Though if she had to use that information to her advantage, so be it. Why else would she have been invited to Senator Reed's gala event?

Allister, after one too many drinks, had confided in her about his numerous affairs. If that information ever got out, it would lead to a massive scandal and the destruction of his supposedly "happy" home life. Sable didn't mind holding onto such secrets. In fact, she relished the power they gave her. Very quickly her societal position was pushed and pushed, right until it brought her to the presidential candidates themselves.

To Coriolanus Snow.

His name kept surfacing after the 10th Hunger Games, lingering in whispers and headlines even after he graduated and vanished for a while. He re-emerged only a year ago, launching a campaign and preaching about his run for office.

Sable watched him on her television late one night, utterly fascinated. He was so well-spoken, his charm radiating through the screen. But it was his eyes that captivated her the most. Icy blue, sharp, and intense—they held your attention, convincing you of anything he said. And there was no denying how handsome he was.

As she watched, a distinct feeling washed over her. She was staring at her next big fish, her ticket to more power than she could ever dream of.

Coriolanus stood before the mirror, meticulously adjusting the knot of his tie when Garrison stormed into the room, his face flushed with frustration.

“Snow, you’re slipping,” Garrison snapped, slamming a folder down on the vanity. “You’re falling behind in the polls, and it’s not because of policy. It’s because people don’t like you. They don’t trust you.”

Coriolanus’s jaw tightened, but he kept his gaze on his reflection. “They don’t need to like me, Garrison. They need to respect me.”

Garrison shook his head, exasperation clear in his voice. “Respect isn’t enough! You're your father's son! You need to have the connection with the people that he didn't, show them you’re one of them—or at least pretend to be. Your charm alone won’t win this. You need to be likable, Coriolanus, or this entire campaign will be for nothing.”

Coriolanus turned to face him, eyes cold and calculating. “And how exactly do you propose I do that, Garrison?” His voice was sharp, laced with impatience. “You want me to throw on a fake smile and kiss babies? I already have to attend every tedious social event and pretend to care about their trivial concerns. How do you imagine I can possibly ‘up my appeal’?”

Garrison met his gaze, refusing to back down. “It’s not about faking it—it’s about showing a side of yourself that the public hasn’t seen. You need to humanize yourself, Coriolanus. Show them you’re more than just a politician with a thirst for power. They need to see you care about more than winning.”

Coriolanus arched an eyebrow, skepticism plain on his face. “And where do you suggest I find this hidden reservoir of charm and relatability? What am I supposed to do, stroll into the garden party tonight and start mingling with the common folk, asking about their families and hobbies?”

“Yes,” Garrison replied firmly. “Exactly that. Start tonight. You have to show them you’re one of them—someone they can relate to, someone they might actually like. Engage with them, listen to their concerns, show a little humility. It’s not about pandering to senators; it’s about making them feel like you’re on the people's side.”

Coriolanus’s expression darkened as he considered Garrison’s words. The very idea of lowering himself to appease the masses made his stomach turn, but the stakes were too high to ignore the advice. He knew Garrison was right. Like it or not, he needed the people’s support if he was going to win this campaign.

“Fine,” Coriolanus said through gritted teeth, turning back to the mirror. “I’ll play along. But don’t expect me to enjoy it.”

Garrison sighed, relief mingled with exasperation. “Just remember, Coriolanus: power isn’t worth much if no one’s willing to follow you. Tonight, give them a reason to believe in you.”

Coriolanus finished adjusting his tie, his reflection staring back at him with a steely resolve. He wasn’t about to let something as trivial as public appeal stand between him and the presidency. If he had to charm the Capitol’s common folk, he would—at least for tonight.

As he smoothed his maroon jacket and headed for the door, his mind was already working out how to play this new role, how to bend it to his advantage. Because in the end, it didn’t matter what mask he wore, as long as he won.

The sun dipped low in the sky, casting a golden hue over the Capitol's most exquisite garden, where flowers from every district bloomed in a riot of color. The air was thick with the scent of roses and the murmur of idle chatter, punctuated by the clink of crystal glasses. Coriolanus Snow stood near a marble fountain, engaged in a measured conversation with Senator Gallis, a man whose support he desperately needed for his campaign.

As Coriolanus spoke, his eyes occasionally flickered over the senator’s shoulder, scanning the crowd. He was alert, focused, but there was a simmering tension just beneath the surface. He felt it keenly, the way the garden's soft light brushed against the evening’s most beautiful attendee. And then, as if summoned by his thoughts, she appeared.

Sable Hanover glided across the grass, her tweed ensemble a cozy cascade of baby blue that seemed to catch the last rays of sunlight. She moved with the effortless grace of someone who knew all eyes were on her and relished in it. Her gaze locked onto Coriolanus, a smile curving her lips as she approached.

“Senator Gallis,” she said smoothly, her voice honeyed and warm, “I hope I’m not interrupting anything too important.”

The senator turned to her, his expression softening as he took in the sight of her. “Not at all, Miss Hanover. It’s always a pleasure.”

Coriolanus felt the slightest pull at the corner of his mouth, an involuntary reaction to her presence. He kept his composure, but his eyes lingered on her, taking in the curve of her neck, the way the light caught the gleam of her pixie hair. There was something about her—something that had him tensing with interest and a vague unease, like he was playing a game where she already knew the outcome.

Sable’s gaze flicked to him, and he saw the glint of mischief in her eyes. “Mr. Snow, you’ve been monopolizing the senator’s time all evening,” she teased lightly. “I was hoping you might save a moment for me. I have something I’d like to discuss—privately.”

The senator raised an eyebrow, clearly intrigued by the exchange. “I suppose that’s my cue to mingle,” he said, a hint of reluctance in his tone. “But don’t think you’re off the hook, Snow. We’ll continue our discussion later. Be kind to him, Sable.”

She smiled back innocently, "Always,"

Coriolanus nodded, watching the senator slip away into the crowd, but his thoughts were already on Sable. She stepped closer, her perfume—a heady mix of jasmine and something darker—filling the air between them.

“Let me guess,” he said, a hint of dry amusement in his voice, “You’re going to make me regret letting the senator go.”

“Maybe,” she replied, tilting her head as she considered him. “But then again, maybe I’ll make it worth your while.”

He couldn’t help but be drawn to her, his gaze tracing the line of her collarbone, the way her lips parted slightly as she spoke. The garden, with all its splendor, seemed to fade into the background, leaving only the two of them standing amidst the blooms.

“Would you get me a drink?” Sable asked, her tone casual, but there was an undercurrent to her words that made it feel like more.

Coriolanus studied her, the way she didn’t fidget, didn’t rush. She simply waited, confident in her request, her eyes never leaving his. There was something almost thrilling in her boldness, in the way she so easily pulled him into her orbit. He was no stranger to charm, but hers was different—it was dangerous, intoxicating, and he wasn’t entirely sure he could resist it.

“Of course,” he said, his voice low as he offered her his arm. She took it without hesitation, her fingers light on his sleeve, and they walked together toward the bar set beneath a pergola draped in ivy.

As they moved through the garden, whispers trailed in their wake, but neither of them seemed to care. Coriolanus couldn’t help but notice how perfectly she fit at his side, as if she belonged there. His mind, usually sharp and calculating, was dulled by her proximity, by the brush of her arm against his as they walked.

When they reached the bar, he signaled the bartender and ordered them both a drink. As they waited, Sable turned to him, her expression more serious now, though the spark in her eyes remained.

“You've really captured my interest,” she said, her voice soft enough that it was only for him. “I believe you’re going to win this campaign, you know.”

Coriolanus met her gaze, his curiosity piqued. “And what makes you so sure?”

“Because I know how badly you want it,” she replied, leaning in just a fraction closer. “And because I know how badly I want to see you win.”

"Really?" he cocked his head.

"Really," she nodded, "Look back through history, you'll find a plethora of decrepit, fuddy-duddy leaders who just continue to enforce the old rules that ran when they were our age. Modern problems require modern solutions after all... and modern leaders, too,"

"I couldn't agree with you more," he replied, "I take it your family will be donating to my campaign?"

Sable chuckled harmoniously, "No, my father has no interest in your campaign. Again -- old, decrepit, fuddy-duddy," she shrugged.

Coriolanus' interest continued to peak, "Then, why are you here?" he asked, "You'll pardon my rudeness, but I doubt you have enough funds to supplement in this election,"

"Well, obviously not," she shook her head nonchalantly, "I have something better. Me,"

"You?"

"Yes,"

The bartender placed two perfectly chilled martinis before them, none the wiser to their hushed conversation. Coriolanus meanwhile wasn't sure whether to burst out laughing, surely there had to be a gag.

"I don't understand," he said, "What exactly are you offering, Ms. Hanover?"

"Myself," she replied simply, "You're lacking in the polls on account of public appeal, are you not? What better way to shake that icy cold exterior than by having one of the Capitol's most eligible women on your arm?"

She appeared completely unfazed by her proposition as she sipped her martini. Her words sent a thrill through him, a rush of something he hadn’t felt in a long time. Desire, yes, but also something more—something that told him this woman, with all her beauty and cunning, could be more than just another admirer. To put simply, he was intrigued.

Coriolanus took a brief look around, establishing that for once the attention was well off of him,"Let's speak in private,"

Grabbing his drink, they snaked around the perimeter of the party until they could come to a quieter area of the garden, not well populated and out of view from the party guests.

"You seem at a loss for words, Mr. Snow," Sable grinned.

"I'm just trying to wrap my head around this, Ms. Hanover," Coriolanus grumbled back, "You're proposing that you... and I... date?" it sounded so drawl and simple when he put it like that.

She nodded, however, "Yes. Well -- not actually. Think of it as something a little more... transactional. Essentially, we pretend we're dating."

Coriolanus still thought she was joking, "You must be really bored, or pulling one over me real good," he said.

"Of course not," Sable replied, "I have a reputation of my own in this city. If the public see you with me, you're bound to earn yourself some brownie points. More brownie points means more numbers in the polls in your favour,"

Coriolanus’s eyes narrowed as Sable’s words lingered in the air, her voice smooth and calculated. The way she leaned in, her eyes gleaming with a mix of challenge and allure, set his mind racing. The conversation with Garrison echoed in his thoughts—you need to be likable, Coriolanus…show them you’re one of them. He’d dismissed the idea at first, but now, as Sable stood before him, offering something more than just flirtation, he began to connect the dots.

Here she was, a woman who could help him bridge that gap, who understood the Capitol’s social landscape better than anyone. Sable wasn't just another pretty face; she was someone who could navigate the intricacies of high society with ease, someone who knew how to charm, manipulate, and command attention. She had the kind of influence that could be incredibly useful—if he played his cards right.

Coriolanus could see it now, the path forming in his mind: a partnership of sorts, where Sable's social prowess would complement his strategic mind. She could help him soften his image, make him more palatable to the Capitol's elite, and by extension, to the broader public. If she was willing to throw her support behind him, it could be the key to turning things around in the polls. Likability, after all, was just another form of power.

He leaned in slightly, mirroring her movement, his voice low and measured. “And what’s in it for you, Sable? Why align yourself with me?”

A slow smile spread across her lips, her eyes flicking to his as if she could see the gears turning in his head. “Because, Coriolanus,” she said softly, “you and I are cut from the same cloth. We both know what it means to want something so badly that we’ll do whatever it takes to get it. And I happen to think you’re the best bet for what’s coming next in Panem.”

Coriolanus studied her, his eyes narrowing slightly as he leaned closer, voice dropping even lower, “Fascinating pitch. Now, what’s your real reason, Sable?”

"Excuse me?"

"Nobody takes their hobby that seriously, especially not national affairs," he told her, "So tell me, what's your reason?"

For a moment, she said nothing, just tilted her head and regarded him with a quiet intensity. Then, as if the idea had always been there, waiting for the perfect moment to surface, her lips curved into a knowing smile. “Alright,” she began, her tone casual, as if discussing the weather, “I’ll tell you, but you're not going to like it,”

He raised a brow, intrigued, "Try me,"

“My parents,” she said, leaning back slightly, fingers tracing the rim of her wine glass, “have been on my back for years about settling down, being a good little house wife. They want me to marry into another high-ranking family, cement my position in Capitol society, yada-yada-yada. You know the drill,”

Coriolanus gave a small nod, already sensing where this was going, but he waited.

“And you, Coriolanus,” she said, her voice dipping into something close to amusement, “are the perfect solution to that problem. You’re on the rise, you’re ambitious, easy on the eyes, and marrying you would get them off my back for good. Plus, it would strengthen your image. A solid union—two powerhouses joined together,”

He blinked, processing her words, but before he could speak, she raised a hand.

“Don’t get me wrong, though,” she continued, eyes meeting his squarely, “I have no interest in you romantically. Behind closed doors, you can do whatever you please. I’m not here for that. This would be a marriage of convenience, nothing more. A partnership—one that benefits us both,”

Coriolanus sat back, his fingers steepled in thought. “You want me to marry you,” he said, slowly, testing the words on his tongue.

“Not immediately, of course. But over time. Think about it,” she said, leaning forward again, her smile turning sharper, “It’s a win-win. We get the Capitol’s attention. We silence anyone who doubts our ambitions. And most importantly, we get what we both want—power, respect, and control over our own lives,”

He could see the calculation in her eyes, the cold pragmatism. She wasn’t lying. For Sable, this was business. Nothing more, nothing less. And that, in some strange way, made the proposal almost… enticing.

“You’d really go through with it?” he asked, still weighing the possibilities.

“Absolutely,” she replied without hesitation. “And trust me, you’ll never have a more loyal partner in this game. Just as long as we keep everything… business,”

Coriolanus felt a flicker of satisfaction at her words. She was offering more than just flirtation or manipulation; she was offering an alliance. One that could give him the edge he needed in a campaign that was rapidly slipping out of his control.

Hell, what did he have to lose?

He allowed himself a small, calculated smile. “You’re not wrong,” he admitted, his voice carrying the weight of understanding. “But if we’re going to do this, I need to know you’re all in, Sable. No half-measures.”

Her smile widened, a flash of something darker, more determined, passing through her eyes. “Oh, I’m all in. But only if you promise me one thing.”

“And what’s that?” he asked, curiosity piqued.

“That when you win,” she said, her voice dropping to a whisper, “you remember who helped you get there.”

Coriolanus held her gaze, the implications clear. This was more than just a casual encounter—it was the beginning of something far more strategic. “Consider it a deal,” he replied, his tone laced with intent.

Sable’s smile was triumphant as she took a step back, giving him a final, lingering look. “Then why don’t we return to the party, we can chat more over dinner?”

As he led her away from the crowd, Coriolanus felt a renewed sense of purpose. Garrison’s words still echoed in his mind, but now they felt less like a burden and more like an opportunity. With Sable by his side, he could craft the image he needed, win the support he lacked—and ultimately, secure the power he craved.

[darkmaga-retard]

Cutting corners?

Hedley Rees

Aug 30, 2024

The Pharmaceutical Supply Chain for Safety Testing

In this post below, AlisonW commented on the various supply chain ‘irregularities’ that have now become apparent in the pharmaceutical supply chain, especially in relation to SARS-CoV-2 injections:

J P Morgan Global Alternatives, the Biotechnology Scam, and Tony Blair

Aug 29

This prompted me to say more about the practicalities of safety testing in the pharmaceutical supply chain. Here we go:

Drug Development Regulations and the Supply Chain

The program of development is dictated by regulatory rules and guidance. A prospective Clinical Trial Sponsor (CTS) has total responsibility for every aspect of the supply chain being put in place. One or more companies may be producing at each stage (raw materials, starting materials, drug substance, drug product, finished product), depending on the supply chain strategy envisaged by the prospective CTS.

Sufficient Drug Substance (DS) will be produced to satisfy the needs of in vitro (test tube) and in vivo (animal) testing. The vast majority is used for in vivo testing in animal models. There is no requirement for the compound to be in any dosage form at this stage.

Sufficient safety data that will subsequently be included in Module 3 and Module 4 of the Electronic Common Technical Document (eCTD) must be collected and analyzed by the prospective CTS. Typically, the data are collected from the contract development and manufacturing organizations (CDMO(s)) and contract research organizations (CRO(s)) carrying out production and testing.

If the prospective CTS considers the data can support an application to embark on trials in humans

[spacetimewithstuartgary]

New Galileo satellites operational after successful in-orbit testing

Three months after their launch from Cape Canaveral, Galileo satellites 29 and 30 have reached their target positions at an altitude of 23,222 km, where they have been fully tested and declared operational.

Both satellites have been deployed on the same orbital plane, one of the three that make up the Galileo constellation. Now two of the three Galileo orbital planes are fully populated, bringing the constellation one launch away from completion. The next couple of Galileo satellites are planned to launch in the coming weeks from the Kennedy Space Center in Florida onboard a Falcon 9.

The two new satellites are active and providing navigation signals to users. Their addition to the constellation slightly increases the accuracy of the system and further guarantees the availability and robustness of Galileo signals.

Testing in orbit

The satellites were launched on 28 April by SpaceX under contract with ESA. A Falcon 9 rocket injected the Galileo satellites into medium Earth orbit, not far from their final position. During the first hours after launch, the Mission Control Team made sure that the satellites had successfully completed the initialization sequence, that the solar arrays were correctly deployed and able to generate power and that the network of ground stations could track and control them correctly.

Early operations were executed by the Galileo Service Operator, supported by a team of around 30 satellite experts from ESA and satellite manufacturer OHB on site at the Galileo Control Center in Oberpfaffenhofen, Germany, under the responsibility of EUSPA.

The drift phase then started, with teams on the ground guiding maneuvers to bring the satellites to their final positions, reached on 24 June.

Over the last months, every component on the satellites has been tested to make sure nothing was damaged by the severe launch conditions. Both platform and payload, including antennas and clocks, have been examined.

On 21 August, ESA, OHB and payload manufacturer SSTL assessed the in-orbit test results and concluded that the satellites had not suffered any degradation during launch. ESA, in collaboration with EUSPA, validated the satellites' performance at system level. In light of these results, the Security Accreditation Board has given the green light for both satellites to begin nominal operations.

This success is a result of the joint efforts of ESA, EUSPA, the European Commission, manufacturer OHB, payload manufacturer SSTL teams at Galileo Control Centers and the Security Accreditation Board.

IMAGE: The European Galileo navigation system has two more satellites in orbit following their launch in the early morning of Sunday, 28 April. With 30 satellites now in orbit, Galileo is expanding its constellation, increasing the reliability, robustness and, ultimately, the precision, benefiting billions of users worldwide. Credit: ESA–P. Carill

[diabolus1exmachina]

Maserati Mistral 

The Maserati Mistral, named after a cold northerly wind of southern France, was the successor to the iconic 3500 GT, it was also the first in a series of classic Maseratis to be given the name of a wind. It was offered both in Coupe and Spyder form. 828 coupés and 125 spyders were built in total. Maggiora of Turin supplied both bodies under contract. The Mistral is the last model from the "Casa del Tridente" or “House of the Trident” to have the famous straight six cylinder, twin-spark, double overhead cam engine, as fitted to the Maserati 250F Grand Prix cars that won 8 Grand Prix between 1954 and 1960 and one F1 World Championship in 1957 driven by Juan Manuel Fangio. The engine also featured hemispherical combustion chambers and was fed by a Lucas indirect fuel injection system which was novelty at the time for Italian car manufacturers. Although the Lucas fuel injection system enhances performance, quite a few owners, especially in the U.S. have converted their cars to Weber carburetors due to difficulties in tuning the system properly, the cost being a loss of resale value due to non-originality. The Lucas fuel system is reliable, and needs little attention when rebuilt and initially adjusted by an expert machinist or master mechanic. Sometimes Bosch pumps are used; although not stock, they offer availability and parts, and are not visible due to their location. Regular use of the automobile prolongs the life of the many Lucas "rubber" seals, while also preventing blockages in the injector's. Several American owners have reported a significant performance increase when changing over from Weber carburetor's to the correct (mechanical) Lucas fuel injection. Maserati subsequently moved on to V8 engines for their later production cars to keep up with the demand for ever more powerful machines. There were three engine variants fitted to the Mistral; 3500, 3700 and 4,000 cc. The most sought after derivative is the 4000 cc model. Only the earliest of the Mistrals were equipped with the 3500 cc engine. Unusually, the body was offered in both aluminum and, from 1967, in steel but no one is quite sure as to how many of each were built. Use of the aluminum body panels had no effect on the performance of the Mistral. The mixture of the aluminum body on a steel substructure can lead to corrosion due to the dissimilar metals. The automobile was standard with a five speed transmission from ZF and also had four wheel solid disc brakes. As was Maserati's practice at the time the front suspension was independent while the rear made do with a solid axle. Speed for the 3.7 liter engine and the 4.0 liter engine was around 7 seconds or a little better and the top speed was around 140 mph (225 km/h) to 145 mph (233 km/h). When leaving the factory the Maserati Mistral originally fitted Pirelli Cinturato 205VR15 tyres (CN72) on Borrani wire wheels. 3500 engine was mounted only in a spyder model, with just 12 made, alongside with 76 of Spyder 3.7 and 37 of Spyder 4.0 versions. Of all spyders 20 were right hand drive models. The body which had been designed by Pietro Frua was first shown in a preview at the Salone Internazionale dell'Automobile di Torino in November 1963. The Maserati Mistral is generally considered as one of the most beautiful Maseratis of all time. It is also often confused to the very similar looking but larger and more powerful AC Frua, which was a Frua design as well.

[third-party-manufacturers]

Third Party Pharma Manufacturing Services | Unimarck Pharma

Unimarck pharma helps you unlock your business potential with its third party pharma manufacturing services. Contact us at +91-172-2244500.

[pharma-company-in-chandigarh]

Pharma Contract Manufacturing Services | Call Us @+91-172-2244500

Unimarck Pharma Provides Best Pharma Contract Manufacturing Services | Call Us @+91-172-2244500 | Our Brand Comes With A Solid Foundation To Offer Services Of Pharma Manufacturing To New Pharma Entrants.

[unimarckpharm]

Pharma Manufacturing | Services For Pharma Industry

Contract manufacturing in the pharmaceutical industry has fostered huge growth among new investors. New entrants are gaining quick credibility connecting to a well-established regulated pharma company to sell pharmaceuticals. Thus the industrialists are maintaining quality standardization for providing high-quality medicine. This has allowed entrepreneurs in India to meet the growing population's demands of medicines. This allows them to  expand their reach in different markets. Many pharma companies are focusing on building technology that in turn improves manufacturing efficiency, leading to quick returns on their investment. It has also  reduced many barriers for new business owners to enter smoothly into this lucrative industry.

As the industry is driven by meeting and providing healthcare treatments in different forms such as tablets, ointments, capsules, and liquid medications, its major focus is on maintaining international quality standardization. Thus, with GMP guidelines, many well reputable pharma companies are increasing chances for new entrants to attract business deals globally. By investing in this industry, you can also get a competitive edge through third party manufacturing. Thus with the right strategies and a good understanding of pharma market dynamics, anyone can thrive in this booming industry.

[usafphantom2]

#onthisday in 1942 the first General Motors FM-1 Wildcat flew. The FM-1 Wildcat had a top speed of 318 mph, range of 770 miles with a service ceiling of 39,400 ft.

@classicwarbirds via Twitter

General Motors FM Wildcat

With Grumman working on their new carrier fighter the F6F Hellcat but with demand for its predecessor the F4F Wildcat still high, the decision was taken to out-source production of the F4F. This led to a contract being agreed on the 18th April 1942 for 1,800 F4F Wildcats to be produced by General Motors' Eastern Aircraft Division and the aircraft built by General Motors would be known as FM-1. The 1st September 1942 saw the first FM-1 fly although this had been produced from parts which Grumman had already manufactured.

Unsurprisingly the FM-1 Wildcat was the same as the Grumman produced F4Fs with the one change occurring with the aircraft's armament. Whilst Grumman produced aircraft had six 0.50-in machine-guns the FM-1s produced by General Motors only had four, however this was offset by an extra 20% of ammunition.

Development of the Wildcat continued and a pair of Grumman built prototype XF4F-8s would provide the basis for the General Motors FM-2. This new version had its fin and rudder made taller and featured a lighter airframe to help take-off performance. The biggest change was the introduction of the Wright R-1820-56 cyclone engine which featured a turbocharger, indeed later FM-2 production aircraft had a water-injection system.

Serving with the United States Navy a number of General Motors FM Wildcats were provided to the United Kingdom under Lend-Lease. These were originally called Martlets before reverting back to the American name of Wildcat.

With a total of 4,777 aircraft being delivered by August 1945, when production ceased, it meant that over 7,500 Wildcats had been built by Grumman and General Motors Combined.

[adamwatchesmovies]

Antiviral (2012)

Writer/director Brandon Cronenberg follows in his father’s body-horror footsteps with Antiviral. Weird and unsettling, you won’t see anything like this one anywhere else.

In the near future, celebrity worship has taken a new form. Avid fans of people like Hannah Geist (Sarah Gadon) want a part of her inside them, want to feel what their idols feel. Some eat cloned celebrity meat. Others get the viruses that make their favorite celebrities sick injected into their bloodstream. At the Lucas Clinic, Syd March (Caleb Landry Jones) sells pathogens to his clients and makes money on the side smuggling these exclusive commodities on the black market. To bypass his work's security measures, he incubates the viruses within himself. When his latest acquisition proves fatal to its host, he must find a cure before it's too late.

The very concept of Antiviral gives you the willies. What’s worse is that it doesn’t seem THAT far-fetched. We live in a world where you can very easily feel like you’re a part of a stranger’s life because you see everything they do. Going to a restaurant so you can eat the replicated flesh of someone you love - even though you’ve never met them - is extreme… but is it more invasive than looking at a leaked sex tape? How many degrees of unhealthiness separate getting a celebrity pathogen from taking a stranger's advice as gospel when it comes to products you should buy, apply on your skin or eat? The people of this world are eating human flesh and making themselves ill because they WANT TO.

Psychologically, the concept gives you the creeps but Antiviral doesn't stop there. Psychologically, it's sick. Physically, it's also sick. Admit it, you get a little squeamish when some medical professional shows you a needle but at least deep down you can feel comfort knowing that this small moment of unpleasantness is for the greater good. You relive that discomfort over and over while watching this film. You see how ill Syd becomes. You can imagine yourself in his shoes thanks to that one time your arm became inflamed after a flu shot. We've all been bedridden with a dreadful cough, thinking we were dying. He's actually dying.

Then there’s the actual plot. What’s worse than willingly giving yourself the same herpes variant some attractive lady contracted? getting some new disease you didn't realize was lethal. Now, this isn’t a pandemic film. We’re not scared that Syd will accidentally cause the end of humanity - this future has measures to prevent diseases from spreading to people who didn't pay. What’s chilling is that this disease might not be natural. Syd was never “meant” to contract this thing that’s in him. More and more, we begin to suspect this bug was manufactured. If it was, for what purpose? In addition to body horror, this is what I’d describe as a "terrify-inc." film; a story that shows how unscrupulous and dangerous big corporations can be when all they care about is money while the government regulations protect them rather than us.

The metaphors in Antiviral are not subtle and some of the characters might be thin but at what it wants to do above all, Antiviral excels. One look at Caleb Landry Jones in those clinically-white rooms and you’re filled with unease. Every shot of a needle penetrating the skin, of blood, mucus, saliva or slime fills you with a new sensation but getting an injection isn’t new… it’s just that something has changed. The ending, in particular, makes you feel a whole lot of “ick!” I mean that in a good way. (On Blu-ray, October 24, 2021)

[lanettcdmo]

Pharmaceutical Contract Manufacturing Services: A Comprehensive Overview

Pharmaceutical contract manufacturing services (PCMS) are essential for the global healthcare industry, offering a vital solution for pharmaceutical companies seeking cost-efficient and timely production of drugs. In recent years, the demand for these services has increased due to the complex nature of drug development, stringent regulatory requirements, and the growing need for specialized manufacturing capabilities. This blog explores the key aspects of pharmaceutical contract manufacturing services, their benefits, and the trends shaping the industry.

What Are Pharmaceutical Contract Manufacturing Services?

Pharmaceutical contract manufacturing refers to outsourcing the production of drugs to third-party organizations. These services include the manufacturing of active pharmaceutical ingredients (APIs), drug products, and packaging. Contract Manufacturing Organizations (CMOs) specialize in large-scale production, allowing pharmaceutical companies to focus on research, marketing, and regulatory compliance without worrying about the logistical challenges of drug production.

Key Types of Contract Manufacturing Services

API Manufacturing: This involves the production of the active ingredients used in pharmaceutical drugs. API manufacturing is a complex process that requires specialized expertise and advanced technologies. CMOs are equipped with the required infrastructure to produce APIs under stringent quality controls.

Formulation Development: CMOs help in the development of formulations, ensuring that drugs are stable, effective, and safe for human consumption. This includes solid-dose formulations like tablets and capsules, liquid formulations, and injectables.

Clinical Trial Manufacturing: Pharmaceutical companies often require small batches of drugs for clinical trials. Contract manufacturers provide this service, ensuring that trial drugs meet the same rigorous standards as full-scale production.

Commercial Manufacturing: Once a drug is approved, large-scale production is necessary to meet market demand. CMOs handle commercial production, ensuring that the product is manufactured in compliance with regulatory standards.

Packaging Services: Packaging plays a critical role in maintaining the safety and efficacy of pharmaceutical products. CMOs offer packaging solutions that meet industry regulations, including child-resistant packaging and tamper-evident seals.

Benefits of Contract Manufacturing

Cost-Effective Production: Setting up and maintaining in-house manufacturing facilities is a costly affair. CMOs allow pharmaceutical companies to reduce capital investment and lower operational costs by leveraging their existing infrastructure.

Focus on Core Competencies: Outsourcing manufacturing allows pharmaceutical companies to focus on their core activities like research and development, marketing, and regulatory compliance. This enables companies to bring innovative drugs to market faster.

Access to Expertise and Technology: CMOs are equipped with cutting-edge technology and possess specialized expertise in drug production, ensuring high-quality output. Pharmaceutical companies benefit from the expertise of experienced professionals without having to invest in expensive equipment and training.

Scalability: Contract manufacturers have the flexibility to scale production volumes according to the needs of the pharmaceutical company. Whether it's a small batch for clinical trials or large-scale commercial production, CMOs can adjust their output to meet demand.

Regulatory Compliance: The pharmaceutical industry is highly regulated, and meeting these standards can be challenging for companies. CMOs are experienced in navigating the regulatory landscape and ensure that all products are compliant with international standards such as Good Manufacturing Practice (GMP).

Industry Trends in Pharmaceutical Contract Manufacturing

Biologics Manufacturing: The rise of biologics, such as monoclonal antibodies and gene therapies, has increased demand for specialized contract manufacturing services. Biologics require different production processes compared to traditional small-molecule drugs, and CMOs are investing in new technologies to meet this demand.

Sustainability and Green Manufacturing: With a growing focus on sustainability, CMOs are adopting greener manufacturing practices. This includes reducing energy consumption, minimizing waste, and using environmentally friendly raw materials.

Advanced Manufacturing Technologies: Innovations such as continuous manufacturing and 3D printing are revolutionizing pharmaceutical production. CMOs are increasingly integrating these technologies to improve efficiency, reduce costs, and shorten production timelines.

Global Expansion: The pharmaceutical contract manufacturing industry is expanding globally, with companies seeking partners in emerging markets like India, China, and Brazil. These regions offer cost-effective production while maintaining high-quality standards, making them attractive locations for outsourcing.

Quality and Risk Management: With increasing regulatory scrutiny, CMOs are investing in robust quality management systems and risk mitigation strategies to ensure that their manufacturing processes meet the highest standards. This includes adopting technologies like blockchain for enhanced traceability and transparency in the supply chain.

Conclusion

Pharmaceutical contract manufacturing services play a pivotal role in the pharmaceutical industry's success. By outsourcing production to specialized CMOs, pharmaceutical companies can reduce costs, improve efficiency, and bring innovative drugs to market faster. As the demand for biologics and advanced manufacturing technologies grows, CMOs will continue to evolve, driving further innovation and growth in the sector.