#corticotropin

[mindblowingscience]

Researchers have found evidence of a potential link between patterns of changes in a key pregnancy hormone called placental corticotropin-releasing hormone and symptoms of postpartum depression. The findings, published in Psychoneuroendocrinology, add to a growing body of research on physiological risk factors during pregnancy tied to adverse postpartum outcomes. “One in 5 women report experiencing elevated depressive symptoms within the year after giving birth,” says lead author Isabel F. Almeida, assistant professor of Chicano/Latino studies and director of the Latina Perinatal Health Lab at the University of California, Irvine.

Continue Reading.

[mcatmemoranda]

Adrenal androgens – The adrenal glands are a prominent source of androgens. In fact, dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) are the most abundant products of the adrenal glands. The major determinant of their production is corticotropin (ACTH). Less than 10 percent of DHEA and DHEAS are produced by the testes or ovaries.

DHEA and DHEAS have little, if any, intrinsic androgenic activity. However, small amounts are converted to androstenedione and then to testosterone (and to estrogen) in both the adrenal glands and peripheral tissues, including hair follicles, sebaceous glands, the prostate, external genitalia, and adipose tissue. Thus, while excess secretion of DHEA and DHEAS defines adrenal hyperandrogenism, the hirsutism and virilization are, in fact, caused by the more potent androgens androstenedione and testosterone.

●Primary adrenal causes of adrenal hyperandrogenism

•Premature adrenarche

•Adrenal tumors – Adenomas and carcinomas, and bilateral macronodular adrenal hyperplasia

●ACTH-dependent causes of adrenal hyperandrogenism:

•Congenital adrenal hyperplasia (common forms such as 21-hydroxylase deficiency, as well as others)

•ACTH-dependent Cushing syndrome

•Primary glucocorticoid resistance syndrome

●Other causes

•Hyperprolactinemia

•Exogenous DHEA intake

•Placental aromatase deficiency

●Management – Management of adrenal hyperandrogenism depends upon the underlying cause.

[catspittle]

Weaponry; aside from his mauling people with his hands and jaws like a starving animal.

bog-standard scythe, made of meteoric iron and cherry wood to give it a little flexibility. It's jagged like something from Final Fantasy, clearly meant to be more decorative and to intimidate than to actually be used. Still, nothing but the very tip of the blade is sharpened any more than is normal. The blade also retracts.

claw gauntlets to be strapped over the wrists. The "claws" are hollow, perfect for stashing needles of fear toxin.

And, of course, the toxin itself. It's often clear to a very pale yellow/orange in color; depends on how much if any bromine is added. Think of it less of a fear toxin proper and more like mustard gas. This is designed to hurt first and foremost, with the hallucinatory aspects and included paralytic being only a bonus to keep victims distracted. There's also a healthy dose of scopolamine and corticotropin contained within it.

[betshy]

Understanding the Hypothalamic-Pituitary-Adrenal (HPA) Axis: A Complete Guide

The Hypothalamic-Pituitary-Adrenal (HPA) Axis is a key player in the body's stress response system. It is a complex network of communication between the hypothalamus, pituitary gland, and adrenal glands that helps the body to respond to stressors and maintain homeostasis. The HPA Axis begins with the hypothalamus, a region of the brain that releases corticotropin-releasing hormone (CRH) in response to stress. CRH then travels to the pituitary gland, which responds by releasing adrenocorticotropic hormone (ACTH). ACTH then stimulates the adrenal glands, located on top of the kidneys, to release cortisol, a stress hormone that helps the body to mobilise energy and respond to the stressor. Cortisol plays a crucial role in the body's stress response by increasing blood sugar levels, suppressing the immune system, and suppressing the reproductive system. It also helps to regulate metabolism, inflammation, and mood. However, chronic stress can lead to dysregulation of the HPA Axis, resulting in persistent elevated cortisol levels that can have negative effects on physical and mental health. Overactivation of the HAP Axis has been linked to a variety of health issues, including anxiety, depression, insomnia, and metabolic disorders. It can also weaken the immune system and increase the risk of cardiovascular disease. On the other hand, dysregulation of the HPA Axis can also result in low cortisol levels, leading to fatigue, weakness, and poor stress response. There are several ways to support the HPA Axis and promote healthy stress response. These include engaging in stress-reducing activities such as meditation, mindfulness, yoga, exercise, and spending time in nature. Eating a balanced diet, getting enough sleep, and maintaining social connections can also help to support the HPA Axis and overall well-being. In conclusion, the Hypothalamic-Pituitary-Adrenal (HPA) Axis plays a critical role in the body's stress response system. By understanding how this complex network of communication works and taking steps to support its healthy functioning, we can better manage stress and promote overall health and well-being. Read the full article

[pharmaffiliates-25]

CAS No : 9002-60-2 | Product Name : Corticotropin | Pharmaffiliates

Buy highly pure Corticotropin, CAS No : 9002-60-2, Mol.Formula : NA, Mol.Weight : NA, from Pharmaffiliates. Login as registered user for prices, availability and discounts.

[thealcyoneblog]

What Does Stressed Skin Look Like? Symptoms, Causes, and Management Tips

Stress is a part of life, and you cannot simply tell someone else to ‘stop stressing.’ Like, what does that even mean? There is something called ‘The Brain-Skin Connection,’ so when you are under acute or chronic stress, the brain perceives it. This, in turn, releases hormones such as Corticotropin-releasing hormones, glucocorticoids, and epinephrine, all of which stimulate cortisol. Have you…

[citrusychology]

How can your physical health be impacted by stress?

Stress eats you alive. Or at least, that's how it feels, right?

I've been having a tough couple of weeks. My medications changed, life got busy, and suddenly it felt like I was fighting for my life to keep my head above water when everyone else was calmly floating along.

This led me to wonder: to what extent does stress impact the body? There's obviously the idea of hair going grey early, but how much further does it go?

Studies have shown that both short and long term stress can worsen connections in the brain related to memory. If you have ever been so stressed over something that you start to do worse in school, you can probably attest to this on a personal level. One study from UC Irvine showed that with short term stress, hormones called corticotropin-releasing hormone (CRH) activate and disrupted the dendritic spines where synapeses are. Synapses transmit information from one neuron to another, so they are extremely important.

In mouse/rat experiments with the same team, they found that by blocking CRH from interating with their receptor molecules, they can prevent stress damage to the dendritic spines. Future medicines or therapies could possibly use that information to help patients with ADHD, PTSD, or other situations where stress negatively impacts memories.

A study from the INRS found that long term work related stress, like a job that puts one in danger, had links to lung, colon, rectal,and stomach cancer, as well as Non-Hodgkin Lymphoma.

If constant pressure can degrade our body to such a degree, we should make more efforts to support those who are struggling. I look around everyday and I see people casually talking about killing themselves and giving up entirely out of stress and exhaustion. I constantly hear: - 'If I skip a day for mental health, I'll have to spend so much time making up work I'll be even more stressed.' -'It's like one awful, stressful thing is over and 15 more pop up with no room to breathe.'-'I'm holding on by a thread, but if I take a break I'll want to die even more...' This mental health crisis, especially among teens, speaks to the lack of support most feel they have in regards to their mental health. More safety nets need to exist so that a few bad days in a row don't build into something that is so stressful to get out of, ending it all or giving up entirely is preferable.

--

Quick, off-topic tangent before we go:

The dendrites we've been talking about come from the greek word "déndron", which literally means tree, since the dendrites look like treee roots in the way they sprawl out.

Dionysus, the greek god of wine, theatre, fertility, and madness has many epithets. One that caught my attention was "Dendrites", meaning he of the trees, alluding to his fertility associations.

Though obviously they come from the same root word and that's really the extent of the connection, I think its interesting that unintentionally, a god who has all these connections to the mind and madness in this way, has a direct connection to the science of the brain. Maybe a bit silly of a connection, but I think it's fun!

Links I Reference:

Stress Influences Brain and Psyche Via Immune System

Short-term Stress Can Affect Learning And Memory

Dendrites

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Check out my website here where I crosspost everything!!

[jorgemarquet]

Larger hypothalamic subfield volumes in patients with chronic insomnia disorder and relationships to levels of corticotropin-releasing hormone - ScienceDirect

[solhwellness]

The Link between Mental Health and Human Trafficking | Solh Wellness

More than 3.3 million people worldwide are victims of sex trafficking, and women make up the majority of these victims, making it a serious problem. There are apparently more than a million kids among them. Due to the illicit nature of the activity, detailed data collection is difficult, which results in low data quality.

It is undeniable that sex trafficking and mental health problems are related. We can better understand the depth of the damage and devise effective recovery strategies by looking at how this relationship grows.

Factors affecting Mental Health of Human Trafficking Victims:

Biological factors: Sex trafficking victims, especially young ones, experience severe psychological stress as a result of sexual exploitation, which causes noticeable changes in the neurochemical and structural makeup of the brain. 

Extreme stress may alter the gene activity in the hypothalamus and other regions of the brain. The synthesis of important stress-related hormones such pro-opiomelanocortin, corticotropin-releasing hormone, adrenocorticotropic hormone, and cortisol may be altered as a result.

Other neuromodulator systems that are affected include those for growth hormone, norepinephrine, GABA, opioids, and 5-HT.  

Genetic factors: Numerous sex trafficking victims come from families where there are high rates of drug abuse, alcoholism, schizophrenia, depression, and schizophrenia. 

Even though there has not yet been any specific research analyzing genetic linkages between these disorders and mental health concerns brought on by sex trafficking, it is crucial to take into account the likelihood that survivors may have a hereditary propensity to have these problems.

A person's sensitivity to stress and vulnerability to diseases like Post-Traumatic Stress Disorder (PTSD) are both influenced by genetics. This tendency is made worse by epigenetic variables brought on by exposures during pregnancy.

Psychosocial factors:Victims of sex trafficking are placed in a challenging circumstance that includes criminality, drug addiction, and poverty. The situation worsens, the violence increases, and the survivors' mental health suffers as a result when these adverse elements combine. 

Some Self Care measures for the Victims of Trafficking :

Controlled Breathing and Relaxation: You may relax your body and mind by relaxing and by controlling your breathing. Stress and anxiety could be lessened as a result. Online resources provide useful techniques.

Being Present in the Moment (Grounding):When you're feeling overwhelmed, concentrating on your senses might help you stay in the present. Spend some time experiencing your environment using your eyes, hands, ears, nose, and palate. This can assist you in maintaining present-moment awareness while reducing powerful emotions.

Joyful Items and Activities:Make a list of all the things you enjoy, such as your favorite products or hobbies. Refer to this list on difficult days and try to find something fun to do.

Physical Self-Care: Physical self-care includes healthy eating and regular exercise, even if it's just a quick stroll outside. Even modest changes can have a big impact on your mental and emotional wellbeing.

Stay Connected: Stay in touch with your friends, family, and other confidantes. One can find solace and a sense of belonging in a network of allies. Having a confidant and support network is crucial

Conclusion

Understanding the biological, genetic, and behavioral histories of sex trafficking survivors is essential to treating their mental health issues. By adopting this holistic viewpoint, we might be able to create remedies that are more potent in easing the severe mental stress that these helpless people experience.

We at Solh Wellness respect your mental health, so we have compiled a variety of useful self-help tools that can be helpful to you. We provide a variety of services, including goal-setting, mood analysis, self-assessment tests, journaling, and access to a vast collection of educational materials. Utilize our wide range of self-help resources to take control of your path to improved mental health and personal growth.

[ainews]

Bronchitis is a condition affecting the airways to the lungs and is often accompanied by a persistent cough. But did you know that having bronchitis can actually be an advantage?

Scientists have discovered that people who have chronic bronchitis have a greater chance of fighting off infections, such as the flu or even pneumonia. This is due to the protective effect the inflammation caused by the bronchitis has on the airways and the immune system. It’s thought to be the result of an overreaction of the body’s immune response, whereby increased levels of inflammation help fight off pathogens.

Bronchitis is also associated with improved stability of the airways and even slower aging. In a study conducted in 2014, researchers studied nearly 900 people with and without bronchitis and found that those with bronchitis had fewer infectious episodes, due to the increases in inflammation and improved immune system.

Another advantage is improved blood pressure regulation. It’s thought that the chronic inflammation of the airways associated with bronchitis triggers an increased production of a hormone called corticotropin-releasing hormone, which helps to regulate blood pressure.

Finally, bronchitis can also be beneficial for those with asthma. The inflammation of airways during bronchitis helps promote better airway stability and even reduces the severity of asthma symptoms.

So, although bronchitis is generally considered a negative thing, it’s worth remembering that this condition can sometimes bring a few benefits.

[edenmartinez]

Angelo Dominguez

age: 42

Gender: Male

OMS Asotiation HC Panamericna de la Salud

PATIENT IS yet not Gave Up

Hipofixis

Triage II

Patien of post surgery with artritis and foot trauma because that happened has in project of designer insider sai'd I felt on floor and my foot was crash

antitussivesCoughing is an essential protective reflex that ensures airway patency, and is one of several methods by which the lungs clear secretions and inhaled foreign material. Therefore an effective cough becomes crucial to maintain airway patency in the presence of exudate and excessive mucus production. Its persistence can cause parents a lot of anxiety, as they worry about its etiology, and it is often accompanied by interruption of the sleep pattern.The cough can be acute or chronic. Acute cough, which can last up to two weeks, often accompanies respiratory tract infections in children. Chronic cough is defined as a cough that lasts longer than two to four weeks.Optional non-narcotic treatmentCoughing is a symptom that frequently leads to pediatric consultation. Normally, preschool-age children have up to eight upper respiratory tract infections accompanied by coughing in the winter season. Cough is common in most acute viral infections of the upper respiratory tract, including those caused by common cold agents such as rhinovirus, coronavirus, and respiratory syncytial virus. Many other diseasessuch as cystic fibrosis, asthma and immunodeficiency processes, can cause coughing.Multiple evidence accumulated in the last 3 decades indicates that there is bidirectional communication between the central nervous (CNS), endocrine, and immune systems from embryonic and neonatal development to the final stages of life. This "immuno-neuro-endocrine" communication is constantly evidenced under stress situations such as infections, inflammatory/autoimmune diseases or trauma, which trigger a series of reactions that activate the immune-neuro-endocrine system. This system is made up of the following axes: 1. hypothalamic-pituitary-adrenal (HPA) that includes cortisol, corticotropin-releasing hormone (CRH) and adrenocorticotropic hormone (ACTH); 2. hypothalamic-pituitary-gonadal (HHG), which includes luteinizing hormone (LH), follicle-stimulating hormone (FSH), gonadotropin-releasing hormone (GnRH), estrogens, progesterone, and androgens; 3. hypothalamic-pituitary-thyroid (HPT) composed of thyroid hormones (T3 and T4), thyroid-stimulating hormone (TSH), and thyrotropin-releasing hormone (TRH) and 4. prolactin/growth hormone (PRL/GH) system ). The messengers of this bidirectional communication are the aforementioned hormones, neuropeptides, “pro-inflammatory” and “anti-inflammatory” cytokines, as well as neurotransmitters that are synthesized by the cells of the 3 systems. These messengers act via receptors

Triage III

Angeloi Dominguez

Age: 43

Gender Male

AngDeCS: LIMBS/injuries; SOFT TISSUE INJURIES/surgery; MICROSURGERY/methods; EXPOSED FRACTURES/surgery.

Vascular injury: adequate hemostasis is required, which guarantees arterial irrigation and venous drainage through suture, placement of the plastic graft or a vein from the patient, for which it is better to stabilize the fracture and avoid tension in the suture.17

External fixation: widely accepted in the treatment of the most severe injuries due to its advantages and technological variants. It is associated with various forms of complications and especially those caused by the wires.7,31-33 Its use should be reserved for AF with severe PB damage, comminuted fractures, with bone substance defect of more than 50% of the circumference. or segmental, multiple injuries, fractures in burned areas or associated with vascular repair and severe joint fractures. It is a general criterion to use FE until it is possible to change it to an internal method motivated by non-adaptation, failure or the emergence of complications, improve comfort and reduce the cost/time ratio.

the patient says: " The latest that afectedme is the stomach i has stomachache during two weeks that I'm receiving treatment....

[myfeeds]

Stress increases Alzheimers risk in female mice but not males

Stress may be one such reason. A study by researchers at Washington University School of Medicine in St. Louis shows that the effect stress has on the brain differs by sex, at least in mice. In stressful situations, levels of the Alzheimer’s protein amyloid beta rises sharply in the brains of females but not males. In addition, the researchers identified a molecular pathway that is active in brain cells from female mice but not male mice, and showed that it accounts for the divergent responses to stress. The findings, published May 2 in Brain, add to a growing collection of evidence that sex matters in health and disease. From cancer to heart disease to arthritis, scientists have found differences between males and females that could potentially affect how men and women respond to efforts to prevent or treat chronic diseases. “How women respond to stress versus how men respond to stress is an important area of research that has implications for not just Alzheimer’s disease but other conditions, too,” said co-corresponding author Carla M. Yuede, PhD, an associate professor of psychiatry. “In recent years, the National Institutes of Health (NIH) has prioritized understanding sex differences in medicine. Stress is one area in which you can clearly see a difference between males and females. This study shows that reducing stress may be more beneficial for women than men, in terms of lowering the risk of Alzheimer’s disease.” Stress falls into the category of socioeconomic risk factors, along with factors such as depression and social isolation, that together account for an estimated 8% of the risk of developing Alzheimer’s. That risk calculation, however, doesn’t take gender into account. Women consistently report higher levels of stress than men, and stress affects women’s bodies differently than men’s in many ways, such as cardiovascular health, immune responses and other issues. Corresponding author John Cirrito, PhD, an associate professor of neurology; Yuede; and first author Hannah Edwards, a graduate student in Cirrito’s lab, reasoned that stress also may affect women’s brains differently than men’s, and these differences may help explain the sex imbalance in Alzheimer’s disease. To find out, they measured levels of amyloid beta — a key Alzheimer’s protein — in the brains of mice every hour for 22 hours, beginning eight hours before the mice experienced stress. The experience was equally stressful for male and female mice, as measured by the levels of stress hormones in their blood. But the responses in their brains were not the same. In female mice, amyloid beta levels rose significantly within the first two hours and stayed elevated through the end of the monitoring period. In male mice, brain amyloid levels did not change overall, although about 20% of them did show a delayed and weak rise in amyloid levels. Further experiments revealed that the difference comes down to a cellular stress response pathway in brain cells. Stress causes the release of a hormone known as corticotropin releasing factor. Neurons from female rodents take up the stress hormone, triggering a cascade of events that results in increasing levels of amyloid beta in the brain. In contrast, neurons from male rodents lack the ability to take up the stress hormone. It is not known whether there are similar sex differences in how human neurons take up stress hormones. “There’s a fundamental biological difference between males and females in how they respond to stress at the cellular level, in both mice and people,” Cirrito said. “We don’t think that stress is the sole factor driving the sex difference in Alzheimer’s disease. There are many other differences between men and women — in hormones, lifestyle, other diseases they have — that undoubtedly contribute in some way. But that stress is driving one aspect of this sex difference I think is very likely.”

[betshy]

The Hypothalamic-Pituitary-Adrenal (HPA) Axis and Mental Health

The hypothalamic-pituitary-adrenal (HPA) axis is a complex system in the body that plays a crucial role in regulating our response to stress. It is made up of three key components - the hypothalamus, the pituitary gland, and the adrenal glands - and when it becomes dysregulated, it can have significant effects on our mental health. When we are faced with a stressful situation, the hypothalamus releases a hormone called corticotropin-releasing hormone (CRH), which signals the pituitary gland to release adrenocorticotropic hormone (ACTH). ACTH then stimulates the adrenal glands to produce cortisol, often referred to as the "stress hormone". Cortisol helps the body cope with stress by increasing glucose levels, suppressing the immune system, and regulating metabolism. While the HPA axis is designed to help us respond to acute stress, chronic stress can lead to dysregulation of this system. Prolonged exposure to stress can result in the overproduction of cortisol, leading to a state of chronic inflammation and heightened anxiety. This can increase the risk of developing mental health conditions such as depression, anxiety disorders, and post-traumatic stress disorder (PTSD). Research has shown that individuals with mood disorders, such as depression and anxiety, often have abnormalities in the HPA axis. High levels of cortisol have been linked to the development and exacerbation of these conditions, while dysfunction in the regulation of cortisol has been implicated in conditions such as Cushing's syndrome and Addison's disease. Furthermore, studies have also shown a strong correlation between childhood trauma and the dysregulation of the HPA axis. Adverse childhood experiences, such as abuse or neglect, can alter the stress response system and increase the risk of mental health disorders later in life. Fortunately, there are ways to support the HPA axis and promote mental well-being. Engaging in stress-reducing activities such as mindfulness, yoga, and meditation can help regulate cortisol levels and improve resilience to stress. Additionally, maintaining a healthy lifestyle through regular exercise, balanced nutrition, and adequate sleep can also support the proper functioning of the HPA axis. In conclusion, the hypothalamic-pituitary-adrenal (HPA) axis plays a vital role in regulating our response to stress and has a significant impact on our mental health. Dysregulation of this system can lead to the development of mood disorders and other mental health conditions. By understanding the relationship between the HPA axis and mental health, we can implement strategies to support this system and promote overall well-being. Read the full article

[igoal88-igoal]

สิวไม่มีหัว บีบก็ไม่ได้ ปล่อยทิ้งไว้ก็ไม่มั่���ใจ ทำไงดี?

สิวไม่มีหัว (Blind Pimples หรือ Cystic Acne) มีชื่อเรียกอีกอย่างหนึ่งว่า สิวตุ่มนูนแดง (Papules) เป็นสิวที่หลายๆคนรู้จักกันเป็นอย่างดี และส่วนใหญ่มักเคยประสบปัญหาสิวอักเสบไม่มีหัวสักครั้งหนึ่งในชีวิต ปัญหาสิวประเภทนี้ มีลักษณะเป็นสิวไม่มีหัว คาสิโนออนไลน์ นูนๆ ตุ่มสีแดง มักพบเป็นสิวขนาดเล็กไปจนถึงขนาดปานกลาง บางรายอาจมองเห็น สิวอุดตัน ไม่มีหัวได้ไม่ค่อยชัดเจน

เนื่องจากอักเสบระดับน้อย จึงเห็นเป็นตุ่มสีแดงจางๆ อย่างไรก็ตาม สิวประเภทนี้ ไม่ควรบีบหรือกดสิวออกมา เพราะอาการอักเสบจะมากยิ่งขึ้น จนทำให้รู้สึกเจ็บปวดในยามสัมผัส ฉะนั้น บทความนี้จะทำให้คุณได้รู้จักกับปัญหา สิว มากขึ้น ไม่ว่าจะเป็นสิวไม่มีหัว นูนๆ เกิดจากอะไร รักษายังไง บริเวณที่มักเกิดสิวไม่มีหัวบ่อยๆคือตรงไหน? รวมไปจนถึงคำถามที่ทุกคนสงสัยบ่อยๆ ไปเรียนรู้พร้อมๆกันได้ที่บทความนี้

สิวไม่มีหัว นูนๆ เกิดจากอะไร?

สิวอักเสบไม่มีหัวเกิดจากความผิดปกติใน pilosebaceous unit เช่นเดียวกับ สิวอักเสบ ที่มีการรวมตัวกันของ เคราติน(Keratin) ไขมันจากต่อมไขมัน และแบคทีเรีย จนทำให้เกิดการอุดตันที่ท่อรูขุมขน(Follicular Plug) และ เชื้อแบคทีเรีย Proprionibacterium acnes (P.acnes) ก็มีส่วนเกี่ยวข้องกับการเกิดสิวนี้เช่นเดียวกัน

แต่สิวไม่มีหัวนี้ เกิดจากการที่ การอุดตันมีการรั่วไหลเข้าสู่ชั้นลึกของผิวหนัง แทนที่จะออกมาด้านบน บางครั้งมีการสร้างเป็นถุงซีสอยู่ใต้ผิวหนัง จนกลายมาเป็นสิวแดงๆไม่มีหัว แบบที่หลายๆคนเคยเห็นกันนั่นเอง Pilosebaceous unit คือ ชื่อที่เรียกรวมระหว่างรูขุมขน(Follicle) และต่อมไขมัน(Sebaceous gland) นอกจากสาเหตุที่กล่าวไว้ในข้างต้นนี้ ยังมีปัจจัยอื่นๆอีกมากมาย ที่สามารถทำให้เกิดสิวไม่มีหัวได้ ดังนี้

1. พันธุกรรม เมื่อพบว่า มีประวัติของสมาชิกภายในครอบครัวเคยเป็นสิว แนะนำเพื่อน igoal ก็มีโอกาสที่บุคคลน���้นจะเป็นสิวด้วยเช่นกัน จากการศึกษา มีประมาณ 62.9% – 78% ที่มีสิวเกิดขึ้น ส่วนใหญ่เป็นเพศชาย มักเกิดสิวบริเวณคอ และมีโอกาสที่จะเป็นแผลเป็นด้วย

2. การเปลี่ยนแปลงของระดับฮอร์โมน ยกตัวอย่างเช่น การเกิดสิวลุกลามขึ้นในช่วงรอบประจำเดือน ซึ่งจากการศึกษา มักพบในเพศหญิง วัยผู้ใหญ่ ประมาณ 56% ที่มีอาการสิวลุกลามในช่วงก่อนมีประจำเดือน

3. ประวัติการใช้ยา ยาบางชนิด สามารถเป็นสาเหตุที่ทำให้เกิดสิวที่ลุกลามขึ้นแบบ Monomorphous ได้ และบางกรณี มีสาเหตุมาจาก anabolic steroids, corticosteroids, corticotropin, phenytoin, lithium, isoniazid, vitamin B complexes, สารประกอบ halogenated และ ยาเคมีบำบัดบางชนิด

4. การใช้ชีวิตประจำวัน ได้แก่ ความเครียดสะสม มลพิษทางอากาศ การสูบบุหรี่ หรือ การใช้ผลิตภัณฑ์เครื่องสำอางต่างๆที่อุดตันผิว เป็นต้น

สิวไม่มีหัวแตกต่างจากสิวอื่นๆอย่างไร?

สิวนูน ไม่มีหัว เป็นสิวที่อยู่ในกลุ่มสิวอักเสบ(inflammatory acne) ซึ่งมีลักษณะเป็นสิวตุ่ม นูนแดง (papule) โดยภายในกลุ่มสิวอักเสบ ยังมีสิวรูปแบบอื่นๆ ที่มีความแตกต่างจากสิวอักเสบไม่มีหัว ดังนี้

สิวหัวหนอง (Pustules) : เป็นเม็ดสิวที่มีความอ่อนนุ่มในระดับหนึ่ง มีของเหลวขังอยู่ภายในสิว และสามารถมองเห็นหนองสีขาวอยู่ภายในสิวได้อย่างชัดเจน ขนาดเม็ดสิวอยู่ในระดับเล็กไปจนถึงปานกลาง

สิวหัวช้าง (Nodule) : สิวเม็ดใหญ่ไม่มีหัว มีความแข็งเหมือน สิวเป็นไต นูนเต่ง เมื่อสัมผัสโดนสิว จะให้ความรู้สึกเจ็บปวดอย่างมาก บางกรณีอาจพบว่าสิวมีการรวมตัวอยู่ใกล้ๆกันเป็นแพ ทำให้แผลหายช้า และมีโอกาสที่จะเกิดแผลเป็นได้สูงมากอีกด้วย

สิวซีสต์ (Cyst) : มักเป็นสิวที่มีขนาดใหญ่ มีหนองและเลือดปะปนอยู่ภายใน มีความอ่อนนุ่ม และมีอาการเจ็บปวดด้วย โดยสิวชนิดนี้ เป็นสิวที่มีความรุนแรงมากที่สุด และมีโอกาสที่จะเกิดแผลเป็น แผลก้อนนูน หรือหลุมสิว หลังการรักษาได้

ส่วนกลุ่มสิวไม่อักเสบ(non-inflammatory acne) ที่เป็นสิวอุดตันรูขุมขน สมัครสมาชิก igoal แต่ไม่มีอาการอักเสบอื่นๆ จะมีความแตกต่างจากสิวไม่มีหัวค่อนข้างมาก ดังนี้

สิวหัวดำ (Blackheads) : สิวหัวดำ เป็นสิวหัวเปิดที่มีลักษณะแบนๆเรียบๆ หรือมีสิวโผล่ขึ้นมาบ้างเล็กน้อย ซึ่งจะมีเคราติน(keratin)และลิพิด(lipid) ฝังอยู่ โดยจะมีสีเข้ม เนื่องจากเกิดปฏิกิริยาออกซิเดชั่น(Oxidation) นั่นเอง

สิวหัวขาว (Whiteheads) : สิวหัวขาว เป็นสิวหัวปิดที่มีลักษณะเป็นหัวสีขาว นูนขึ้นเล็กน้อย มักมีขนาดเล็ก และไม่มีรูเปิดของสิวที่สามารถมองเห็นได้อย่างชัดเจน